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profileBrian Jason Wainger, M.D., Ph.D.

TitleAssistant Professor of Anaesthesia
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia
AddressMassachusetts General Hospital
Anesthesia
55 Fruit St
Boston MA 02114
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
DP2NS106664     (WAINGER, BRIAN JASON)Sep 25, 2017 - Sep 29, 2022
NIH/NINDS
A Human Stem Cell-Derived Neuromuscular Junction Model for Amyotrophic Lateral Sclerosis
Role: Principal Investigator

K08NS082364     (WAINGER, BRIAN JASON)Apr 1, 2014 - Mar 31, 2019
NIH/NINDS
Defining an Electrophysiological Phenotype of ALS Patient-Derived Motor Neurons
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wainger BJ, Cudkowicz ME. Cortical Hyperexcitability in Amyotrophic Lateral Sclerosis: C9orf72 Repeats. JAMA Neurol. 2015 Nov; 72(11):1235-6. PMID: 26348624.
    View in: PubMed
  2. McNeish J, Gardner JP, Wainger BJ, Woolf CJ, Eggan K. From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial. Cell Stem Cell. 2015 Jul 02; 17(1):8-10. PMID: 26140603.
    View in: PubMed
  3. Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24. PMID: 25420066; PMCID: PMC4429606.
  4. Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 2014 Nov 13; 515(7526):274-8. PMID: 25307057; PMCID: PMC4366007.
  5. Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 2014 Jun 05; 14(6):781-95. PMID: 24704492; PMCID: PMC4653065.
  6. Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 2014 Apr 10; 7(1):1-11. PMID: 24703839; PMCID: PMC4023477.
  7. Giblin K, Newmark JL, Brenner GJ, Wainger BJ. Headache plus: trigeminal and autonomic features in a case of cervicogenic headache responsive to third occipital nerve radiofrequency ablation. Pain Med. 2014 Mar; 15(3):473-8. PMID: 24401103.
    View in: PubMed
  8. Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block. Br J Pharmacol. 2014 Jan; 171(2):438-51. PMID: 24117225; PMCID: PMC3904263.
  9. Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013 Sep 05; 501(7465):52-7. PMID: 23965627; PMCID: PMC3773968.
  10. Yang YM, Gupta SK, Kim KJ, Powers BE, Cerqueira A, Wainger BJ, Ngo HD, Rosowski KA, Schein PA, Ackeifi CA, Arvanites AC, Davidow LS, Woolf CJ, Rubin LL. A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell. 2013 Jun 06; 12(6):713-26. PMID: 23602540; PMCID: PMC3707511.
  11. Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 2013 Mar 28; 495(7442):474-80. PMID: 23474986; PMCID: PMC3674495.
  12. Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, Woolf CJ, Eggan K. Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell. 2011 Sep 02; 9(3):205-18. PMID: 21852222; PMCID: PMC3188987.
  13. Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, Henderson CE, Wichterle H, Eggan K. A functionally characterized test set of human induced pluripotent stem cells. Nat Biotechnol. 2011 Mar; 29(3):279-86. PMID: 21293464; PMCID: PMC3229307.
  14. Edlow BL, Wainger BJ, Frosch MP, Copen WA, Rathmell JP, Rost NS. Posterior circulation stroke after C1-C2 intraarticular facet steroid injection: evidence for diffuse microvascular injury. Anesthesiology. 2010 Jun; 112(6):1532-5. PMID: 20460995.
    View in: PubMed
  15. Wainger BJ, Rathmell JP. Perils of intravascular methylprednisolone injection into the vertebral artery. J Bone Joint Surg Am. 2009 May; 91(5):1277-8; author reply 1278. PMID: 19411485.
    View in: PubMed
  16. Santoro B, Wainger BJ, Siegelbaum SA. Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction. J Neurosci. 2004 Nov 24; 24(47):10750-62. PMID: 15564593.
    View in: PubMed
  17. Wainger BJ, DeGennaro M, Santoro B, Siegelbaum SA, Tibbs GR. Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature. 2001 Jun 14; 411(6839):805-10. PMID: 11459060.
    View in: PubMed
  18. Notterman D, Young S, Wainger B, Levine AJ. Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activity. Oncogene. 1998 Nov 26; 17(21):2743-51. PMID: 9840938.
    View in: PubMed
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