Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Stephanie Beth Seminara, M.D.


Investigating incidence of Fabry disease in patients with cryptogenic/ischemic stroke
Summer, 02/04/13 - 07/17/13
Rare Variants in Genes Implicated in GnRH Deficiency in Constitutional Delay of Puberty Patients
Summer, 05/21/12 - 07/27/12

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01FD005712 (SEMINARA, STEPHANIE BETH) Apr 1, 2018 - Mar 31, 2022
    Phase 2 Kp-10 for Dopamine Agonist Intolerant Hyperprolactinemia IND 74,977
    Role: Principal Investigator
  2. K24HD067388 (SEMINARA, STEPHANIE BETH) Sep 10, 2011 - Aug 31, 2016
    Kisspeptin Physiology in Human Reproduction
    Role: Principal Investigator
  3. R01HD043341 (SEMINARA, STEPHANIE BETH) Apr 1, 2003 - Mar 31, 2008
    Kisspeptin and Neurokinin B: Physiology in Monkey to Pathophysiology in Human
    Role: Principal Investigator
  4. P50HD028138 (SEMINARA, STEPHANIE BETH) Apr 1, 1997 - Mar 31, 2021
    Harvard Reproductive Endocrine Sciences Center
    Role: Co-Principal Investigator
  5. U54HD028138 (CROWLEY, WILLIAM FRANCIS) Apr 1, 1997 - Mar 31, 2016
    Harvard Reproductive Endocrine Sciences Center
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Delaney A, Burkholder AB, Lavender CA, Plummer L, Mericq V, Merino PM, Quinton R, Lewis KL, Meader BN, Albano A, Shaw ND, Welt CK, Martin KA, Seminara SB, Biesecker LG, Bailey-Wilson JE, Hall JE. Increased Burden of Rare Sequence Variants in GnRH-Associated Genes in Women with Hypothalamic Amenorrhea. J Clin Endocrinol Metab. 2020 Sep 01. PMID: 32870266.
  2. Chan YM, Lippincott MF, Sales Barroso P, Alleyn C, Brodsky J, Granados H, Roberts SA, Sandler C, Srivatsa A, Seminara SB. Using Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal Delay. J Clin Endocrinol Metab. 2020 Aug 01; 105(8). PMID: 32232399.
  3. Xu W, Plummer L, Quinton R, Swords F, Crowley WF, Seminara SB, Balasubramanian R. Hypogonadotropic hypogonadism due to variants in RAB3GAP2: expanding the phenotypic and genotypic spectrum of Martsolf syndrome. Cold Spring Harb Mol Case Stud. 2020 06; 6(3). PMID: 32376645.
  4. León S, Fergani C, Talbi R, Maguire CA, Gerutshang A, Seminara SB, Navarro VM. Tachykinin signaling is required for the induction of the preovulatory LH surge and normal LH pulses. Neuroendocrinology. 2020 Jun 08. PMID: 32512561.
  5. Delaney A, Volochayev R, Meader B, Lee J, Almpani K, Noukelak GY, Henkind J, Chalmers L, Law JR, Williamson KA, Jacobsen CM, Buitrago TP, Perez O, Cho CH, Kaindl A, Rauch A, Steindl K, Garcia JE, Russell BE, Prasad R, Mondal UK, Reigstad HM, Clements S, Kim S, Inoue K, Arora G, Salnikov KB, DiOrio NP, Prada R, Capri Y, Morioka K, Mizota M, Zechi-Ceide RM, Kokitsu-Nakata NM, Tonello C, Vendramini-Pittoli S, da Silva Dalben G, Balasubramanian R, Dwyer AA, Seminara SB, Crowley WF, Plummer L, Hall JE, Graham JM, Lin AE, Shaw ND. Insight Into the Ontogeny of GnRH Neurons From Patients Born Without a Nose. J Clin Endocrinol Metab. 2020 May 01; 105(5). PMID: 32034419.
  6. Jee YH, Won S, Lui JC, Jennings M, Whalen P, Yue S, Temnycky AG, Barnes KM, Cheetham T, Boden MG, Radovick S, Quinton R, Leschek EW, Aguilera G, Yanovski JA, Seminara SB, Crowley WF, Delaney A, Roche KW, Baron J. DLG2 variants in patients with pubertal disorders. Genet Med. 2020 Aug; 22(8):1329-1337. PMID: 32341572.
  7. Garcia JP, Keen KL, Seminara SB, Terasawa E. Role of Kisspeptin and NKB in Puberty in Nonhuman Primates: Sex Differences. Semin Reprod Med. 2019 03; 37(2):47-55. PMID: 31847024.
  8. Lippincott MF, León S, Chan YM, Fergani C, Talbi R, Farooqi IS, Jones CM, Arlt W, Stewart SE, Cole TR, Terasawa E, Hall JE, Shaw ND, Navarro VM, Seminara SB. Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling. J Clin Endocrinol Metab. 2019 10 01; 104(10):4304-4318. PMID: 31132118.
  9. Dwyer AA, Chavan NR, Lewkowitz-Shpuntoff H, Plummer L, Hayes FJ, Seminara SB, Crowley WF, Pitteloud N, Balasubramanian R. Functional Hypogonadotropic Hypogonadism in Men: Underlying Neuroendocrine Mechanisms and Natural History. J Clin Endocrinol Metab. 2019 08 01; 104(8):3403-3414. PMID: 31220265.
  10. Salonia A, Rastrelli G, Hackett G, Seminara SB, Huhtaniemi IT, Rey RA, Hellstrom WJG, Palmert MR, Corona G, Dohle GR, Khera M, Chan YM, Maggi M. Paediatric and adult-onset male hypogonadism. Nat Rev Dis Primers. 2019 May 30; 5(1):38. PMID: 31147553.
  11. Laisk T, Kukuškina V, Palmer D, Laber S, Chen CY, Ferreira T, Rahmioglu N, Zondervan K, Becker C, Smoller JW, Lippincott M, Salumets A, Granne I, Seminara S, Neale B, Mägi R, Lindgren CM. Large-scale meta-analysis highlights the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length. Hum Mol Genet. 2018 12 15; 27(24):4323-4332. PMID: 30202859.
    Citations:    Fields:    
  12. Lippincott MF, Nguyen K, Delaney A, Chan YM, Seminara SB. Assessing Sex Steroid Influence on Kisspeptin Responsiveness in Idiopathic Hypogonadotropic Hypogonadism. J Endocr Soc. 2018 Nov 01; 2(11):1293-1305. PMID: 30430143.
  13. Garcia JP, Keen KL, Kenealy BP, Seminara SB, Terasawa E. Role of Kisspeptin and Neurokinin B Signaling in Male Rhesus Monkey Puberty. Endocrinology. 2018 08 01; 159(8):3048-3060. PMID: 29982393.
    Citations:    Fields:    
  14. Teive HAG, Camargo CHF, Sato MT, Shiokawa N, Boguszewski CL, Raskin S, Buck C, Seminara SB, Munhoz RP. Different Cerebellar Ataxia Phenotypes Associated with Mutations of the PNPLA6 Gene in Brazilian Patients with Recessive Ataxias. Cerebellum. 2018 Jun; 17(3):380-385. PMID: 29248984.
    Citations:    Fields:    
  15. Chan YM, Lippincott MF, Kusa TO, Seminara SB. Divergent responses to kisspeptin in children with delayed puberty. JCI Insight. 2018 04 19; 3(8). PMID: 29669934.
    Citations:    Fields:    
  16. Lehman MN, Coolen LM, Steiner RA, Neal-Perry G, Wang L, Moenter SM, Moore AM, Goodman RL, Hwa-Yeo S, Padilla SL, Kauffman AS, Garcia J, Kelly MJ, Clarkson J, Radovick S, Babwah AV, Leon S, Tena-Sempere M, Comninos A, Seminara S, Dhillo WS, Levine J, Terasawa E, Negron A, Herbison AE. The 3rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond":Unresolved questions, challenges and future directions for the field. J Neuroendocrinol. 2018 Apr 14; e12600. PMID: 29656508.
    Citations:    Fields:    
  17. Terasawa E, Garcia JP, Seminara SB, Keen KL. Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates. Front Endocrinol (Lausanne). 2018; 9:148. PMID: 29681889.
  18. Shahab M, Lippincott M, Chan YM, Davies A, Merino PM, Plummer L, Mericq V, Seminara S. Discordance in the Dependence on Kisspeptin Signaling in Mini Puberty vs Adolescent Puberty: Human Genetic Evidence. J Clin Endocrinol Metab. 2018 04 01; 103(4):1273-1276. PMID: 29452377.
    Citations:    Fields:    Translation:HumansCells
  19. Garcia JP, Guerriero KA, Keen KL, Kenealy BP, Seminara SB, Terasawa E. Kisspeptin and Neurokinin B Signaling Network Underlies the Pubertal Increase in GnRH Release in Female Rhesus Monkeys. Endocrinology. 2017 10 01; 158(10):3269-3280. PMID: 28977601.
    Citations: 1     Fields:    Translation:AnimalsCells
  20. Lippincott MF, Chan YM, Rivera Morales D, Seminara SB. Continuous Kisspeptin Administration in Postmenopausal Women: Impact of Estradiol on Luteinizing Hormone Secretion. J Clin Endocrinol Metab. 2017 06 01; 102(6):2091-2099. PMID: 28368443.
    Citations:    Fields:    Translation:Humans
  21. Shaw ND, Brand H, Kupchinsky ZA, Bengani H, Plummer L, Jones TI, Erdin S, Williamson KA, Rainger J, Stortchevoi A, Samocha K, Currall BB, Dunican DS, Collins RL, Willer JR, Lek A, Lek M, Nassan M, Pereira S, Kammin T, Lucente D, Silva A, Seabra CM, Chiang C, An Y, Ansari M, Rainger JK, Joss S, Smith JC, Lippincott MF, Singh SS, Patel N, Jing JW, Law JR, Ferraro N, Verloes A, Rauch A, Steindl K, Zweier M, Scheer I, Sato D, Okamoto N, Jacobsen C, Tryggestad J, Chernausek S, Schimmenti LA, Brasseur B, Cesaretti C, García-Ortiz JE, Buitrago TP, Silva OP, Hoffman JD, Mühlbauer W, Ruprecht KW, Loeys BL, Shino M, Kaindl AM, Cho CH, Morton CC, Meehan RR, van Heyningen V, Liao EC, Balasubramanian R, Hall JE, Seminara SB, Macarthur D, Moore SA, Yoshiura KI, Gusella JF, Marsh JA, Graham JM, Lin AE, Katsanis N, Jones PL, Crowley WF, Davis EE, FitzPatrick DR, Talkowski ME. Corrigendum: SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Nat Genet. 2017 05 26; 49(6):969. PMID: 28546579.
    Citations:    Fields:    
  22. Shaw ND, Brand H, Kupchinsky ZA, Bengani H, Plummer L, Jones TI, Erdin S, Williamson KA, Rainger J, Stortchevoi A, Samocha K, Currall BB, Dunican DS, Collins RL, Willer JR, Lek A, Lek M, Nassan M, Pereira S, Kammin T, Lucente D, Silva A, Seabra CM, Chiang C, An Y, Ansari M, Rainger JK, Joss S, Smith JC, Lippincott MF, Singh SS, Patel N, Jing JW, Law JR, Ferraro N, Verloes A, Rauch A, Steindl K, Zweier M, Scheer I, Sato D, Okamoto N, Jacobsen C, Tryggestad J, Chernausek S, Schimmenti LA, Brasseur B, Cesaretti C, García-Ortiz JE, Buitrago TP, Silva OP, Hoffman JD, Mühlbauer W, Ruprecht KW, Loeys BL, Shino M, Kaindl AM, Cho CH, Morton CC, Meehan RR, van Heyningen V, Liao EC, Balasubramanian R, Hall JE, Seminara SB, Macarthur D, Moore SA, Yoshiura KI, Gusella JF, Marsh JA, Graham JM, Lin AE, Katsanis N, Jones PL, Crowley WF, Davis EE, FitzPatrick DR, Talkowski ME. SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Nat Genet. 2017 Feb; 49(2):238-248. PMID: 28067909.
    Citations: 14     Fields:    Translation:Humans
  23. Richards MR, Plummer L, Chan YM, Lippincott MF, Quinton R, Kumanov P, Seminara SB. Phenotypic spectrum of POLR3B mutations: isolated hypogonadotropic hypogonadism without neurological or dental anomalies. J Med Genet. 2017 01; 54(1):19-25. PMID: 27512013.
    Citations: 3     Fields:    Translation:HumansCells
  24. Lippincott MF, Chan YM, Delaney A, Rivera-Morales D, Butler JP, Seminara SB. Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty. J Clin Endocrinol Metab. 2016 08; 101(8):3061-9. PMID: 27214398.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  25. Zhu J, Choa RE, Guo MH, Plummer L, Buck C, Palmert MR, Hirschhorn JN, Seminara SB, Chan YM. A shared genetic basis for self-limited delayed puberty and idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2015 Apr; 100(4):E646-54. PMID: 25636053.
    Citations: 10     Fields:    Translation:Humans
  26. True C, Nasrin Alam S, Cox K, Chan YM, Seminara SB. Neurokinin B is critical for normal timing of sexual maturation but dispensable for adult reproductive function in female mice. Endocrinology. 2015 Apr; 156(4):1386-97. PMID: 25574869.
    Citations: 10     Fields:    Translation:AnimalsCells
  27. Chan YM, Lippincott MF, Butler JP, Sidhoum VF, Li CX, Plummer L, Seminara SB. Exogenous kisspeptin administration as a probe of GnRH neuronal function in patients with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2014 Dec; 99(12):E2762-71. PMID: 25226293.
    Citations: 4     Fields:    Translation:HumansCells
  28. Navarro VM, Bosch MA, León S, Simavli S, True C, Pinilla L, Carroll RS, Seminara SB, Tena-Sempere M, Rønnekleiv OK, Kaiser UB. The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Endocrinology. 2015 Feb; 156(2):627-37. PMID: 25422875.
    Citations: 19     Fields:    Translation:Animals
  29. Seminara SB. Fatness and fertility: which direction? J Clin Invest. 2014 Jul; 124(7):2853-4. PMID: 24937420.
    Citations: 1     Fields:    Translation:HumansAnimals
  30. Calder M, Chan YM, Raj R, Pampillo M, Elbert A, Noonan M, Gillio-Meina C, Caligioni C, Bérubé NG, Bhattacharya M, Watson AJ, Seminara SB, Babwah AV. Implantation failure in female Kiss1-/- mice is independent of their hypogonadic state and can be partially rescued by leukemia inhibitory factor. Endocrinology. 2014 Aug; 155(8):3065-78. PMID: 24877624.
    Citations: 9     Fields:    Translation:Animals
  31. Noel SD, Abreu AP, Xu S, Muyide T, Gianetti E, Tusset C, Carroll J, Latronico AC, Seminara SB, Carroll RS, Kaiser UB. TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients. FASEB J. 2014 Apr; 28(4):1924-37. PMID: 24376026.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  32. Shi CH, Schisler JC, Rubel CE, Tan S, Song B, McDonough H, Xu L, Portbury AL, Mao CY, True C, Wang RH, Wang QZ, Sun SL, Seminara SB, Patterson C, Xu YM. Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP. Hum Mol Genet. 2014 Feb 15; 23(4):1013-24. PMID: 24113144.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  33. Lippincott MF, True C, Seminara SB. Use of genetic models of idiopathic hypogonadotrophic hypogonadism in mice and men to understand the mechanisms of disease. Exp Physiol. 2013 Nov; 98(11):1522-7. PMID: 23955308.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  34. Popa SM, Moriyama RM, Caligioni CS, Yang JJ, Cho CM, Concepcion TL, Oakley AE, Lee IH, Sanz E, Amieux PS, Caraty A, Palmiter RD, Navarro VM, Chan YM, Seminara SB, Clifton DK, Steiner RA. Redundancy in Kiss1 expression safeguards reproduction in the mouse. Endocrinology. 2013 Aug; 154(8):2784-94. PMID: 23736293.
    Citations: 12     Fields:    Translation:AnimalsCells
  35. Margolin DH, Kousi M, Chan YM, Lim ET, Schmahmann JD, Hadjivassiliou M, Hall JE, Adam I, Dwyer A, Plummer L, Aldrin SV, O'Rourke J, Kirby A, Lage K, Milunsky A, Milunsky JM, Chan J, Hedley-Whyte ET, Daly MJ, Katsanis N, Seminara SB. Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination. N Engl J Med. 2013 May 23; 368(21):1992-2003. PMID: 23656588.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  36. Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet. 2013 May 02; 92(5):725-43. PMID: 23643382.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  37. Costa-Barbosa FA, Balasubramanian R, Keefe KW, Shaw ND, Al-Tassan N, Plummer L, Dwyer AA, Buck CL, Choi JH, Seminara SB, Quinton R, Monies D, Meyer B, Hall JE, Pitteloud N, Crowley WF. Prioritizing genetic testing in patients with Kallmann syndrome using clinical phenotypes. J Clin Endocrinol Metab. 2013 May; 98(5):E943-53. PMID: 23533228.
    Citations: 22     Fields:    Translation:HumansCells
  38. Liu Z, Ren C, Jones W, Chen P, Seminara SB, Chan YM, Smith NF, Covey JM, Wang J, Chan KK. LC-MS/MS quantification of a neuropeptide fragment kisspeptin-10 (NSC 741805) and characterization of its decomposition product and pharmacokinetics in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May 01; 926:1-8. PMID: 23524040.
    Citations: 4     Fields:    Translation:AnimalsCells
  39. Abel BS, Shaw ND, Brown JM, Adams JM, Alati T, Martin KA, Pitteloud N, Seminara SB, Plummer L, Pignatelli D, Crowley WF, Welt CK, Hall JE. Responsiveness to a physiological regimen of GnRH therapy and relation to genotype in women with isolated hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2013 Feb; 98(2):E206-16. PMID: 23341491.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  40. Silveira LG, Latronico AC, Seminara SB. Kisspeptin and clinical disorders. Adv Exp Med Biol. 2013; 784:187-99. PMID: 23550007.
    Citations: 5     Fields:    Translation:HumansCells
  41. Sidhoum VF, Chan YM, Lippincott MF, Balasubramanian R, Quinton R, Plummer L, Dwyer A, Pitteloud N, Hayes FJ, Hall JE, Martin KA, Boepple PA, Seminara SB. Reversal and relapse of hypogonadotropic hypogonadism: resilience and fragility of the reproductive neuroendocrine system. J Clin Endocrinol Metab. 2014 Mar; 99(3):861-70. PMID: 24423288.
    Citations: 24     Fields:    Translation:Humans
  42. Tusset C, Noel SD, Trarbach EB, Silveira LF, Jorge AA, Brito VN, Cukier P, Seminara SB, Mendonça BB, Kaiser UB, Latronico AC. Mutational analysis of TAC3 and TACR3 genes in patients with idiopathic central pubertal disorders. Arq Bras Endocrinol Metabol. 2012 Dec; 56(9):646-52. PMID: 23329188.
    Citations: 11     Fields:    Translation:Humans
  43. George JT, Seminara SB. Kisspeptin and the hypothalamic control of reproduction: lessons from the human. Endocrinology. 2012 Nov; 153(11):5130-6. PMID: 23015291.
    Citations: 5     Fields:    Translation:HumansCells
  44. Gianetti E, Hall JE, Au MG, Kaiser UB, Quinton R, Stewart JA, Metzger DL, Pitteloud N, Mericq V, Merino PM, Levitsky LL, Izatt L, Lang-Muritano M, Fujimoto VY, Dluhy RG, Chase ML, Crowley WF, Plummer L, Seminara SB. When genetic load does not correlate with phenotypic spectrum: lessons from the GnRH receptor (GNRHR). J Clin Endocrinol Metab. 2012 Sep; 97(9):E1798-807. PMID: 22745237.
    Citations: 10     Fields:    Translation:Humans
  45. Chan YM, Butler JP, Sidhoum VF, Pinnell NE, Seminara SB. Kisspeptin administration to women: a window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle. J Clin Endocrinol Metab. 2012 Aug; 97(8):E1458-67. PMID: 22577171.
    Citations: 17     Fields:    Translation:Humans
  46. Yang JJ, Caligioni CS, Chan YM, Seminara SB. Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men. Endocrinology. 2012 Mar; 153(3):1498-508. PMID: 22253416.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  47. Lewkowitz-Shpuntoff HM, Hughes VA, Plummer L, Au MG, Doty RL, Seminara SB, Chan YM, Pitteloud N, Crowley WF, Balasubramanian R. Olfactory phenotypic spectrum in idiopathic hypogonadotropic hypogonadism: pathophysiological and genetic implications. J Clin Endocrinol Metab. 2012 Jan; 97(1):E136-44. PMID: 22072740.
    Citations: 16     Fields:    Translation:Humans
  48. Chan YM, Broder-Fingert S, Paraschos S, Lapatto R, Au M, Hughes V, Bianco SD, Min L, Plummer L, Cerrato F, De Guillebon A, Wu IH, Wahab F, Dwyer A, Kirsch S, Quinton R, Cheetham T, Ozata M, Ten S, Chanoine JP, Pitteloud N, Martin KA, Schiffmann R, Van der Kamp HJ, Nader S, Hall JE, Kaiser UB, Seminara SB. GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1. J Clin Endocrinol Metab. 2011 Nov; 96(11):E1771-81. PMID: 21880801.
    Citations: 19     Fields:    Translation:HumansAnimals
  49. Ramaswamy S, Seminara SB, Plant TM. Evidence from the agonadal juvenile male rhesus monkey (Macaca mulatta) for the view that the action of neurokinin B to trigger gonadotropin-releasing hormone release is upstream from the kisspeptin receptor. Neuroendocrinology. 2011; 94(3):237-45. PMID: 21832818.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  50. Tornberg J, Sykiotis GP, Keefe K, Plummer L, Hoang X, Hall JE, Quinton R, Seminara SB, Hughes V, Van Vliet G, Van Uum S, Crowley WF, Habuchi H, Kimata K, Pitteloud N, Bülow HE. Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11524-9. PMID: 21700882.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  51. Wahab F, Quinton R, Seminara SB. The kisspeptin signaling pathway and its role in human isolated GnRH deficiency. Mol Cell Endocrinol. 2011 Oct 22; 346(1-2):29-36. PMID: 21704672.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  52. Chan YM, Butler JP, Pinnell NE, Pralong FP, Crowley WF, Ren C, Chan KK, Seminara SB. Kisspeptin resets the hypothalamic GnRH clock in men. J Clin Endocrinol Metab. 2011 Jun; 96(6):E908-15. PMID: 21470997.
    Citations: 28     Fields:    Translation:Humans
  53. Caronia LM, Martin C, Welt CK, Sykiotis GP, Quinton R, Thambundit A, Avbelj M, Dhruvakumar S, Plummer L, Hughes VA, Seminara SB, Boepple PA, Sidis Y, Crowley WF, Martin KA, Hall JE, Pitteloud N. A genetic basis for functional hypothalamic amenorrhea. N Engl J Med. 2011 Jan 20; 364(3):215-25. PMID: 21247312.
    Citations: 34     Fields:    Translation:Humans
  54. Shaw ND, Seminara SB, Welt CK, Au MG, Plummer L, Hughes VA, Dwyer AA, Martin KA, Quinton R, Mericq V, Merino PM, Gusella JF, Crowley WF, Pitteloud N, Hall JE. Expanding the phenotype and genotype of female GnRH deficiency. J Clin Endocrinol Metab. 2011 Mar; 96(3):E566-76. PMID: 21209029.
    Citations: 27     Fields:    Translation:Humans
  55. Wahab F, Ullah F, Chan YM, Seminara SB, Shahab M. Decrease in hypothalamic Kiss1 and Kiss1r expression: a potential mechanism for fasting-induced suppression of the HPG axis in the adult male rhesus monkey (Macaca mulatta). Horm Metab Res. 2011 Feb; 43(2):81-5. PMID: 21154197.
    Citations: 10     Fields:    Translation:AnimalsCells
  56. Martin C, Balasubramanian R, Dwyer AA, Au MG, Sidis Y, Kaiser UB, Seminara SB, Pitteloud N, Zhou QY, Crowley WF. The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations. Endocr Rev. 2011 Apr; 32(2):225-46. PMID: 21037178.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  57. Sykiotis GP, Plummer L, Hughes VA, Au M, Durrani S, Nayak-Young S, Dwyer AA, Quinton R, Hall JE, Gusella JF, Seminara SB, Crowley WF, Pitteloud N. Oligogenic basis of isolated gonadotropin-releasing hormone deficiency. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15140-4. PMID: 20696889.
    Citations: 86     Fields:    Translation:Humans
  58. Balasubramanian R, Dwyer A, Seminara SB, Pitteloud N, Kaiser UB, Crowley WF. Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neurons. Neuroendocrinology. 2010; 92(2):81-99. PMID: 20606386.
    Citations: 23     Fields:    Translation:HumansAnimals
  59. Ramaswamy S, Seminara SB, Ali B, Ciofi P, Amin NA, Plant TM. Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus. Endocrinology. 2010 Sep; 151(9):4494-503. PMID: 20573725.
    Citations: 87     Fields:    Translation:HumansAnimals
  60. Sykiotis GP, Pitteloud N, Seminara SB, Kaiser UB, Crowley WF. Deciphering genetic disease in the genomic era: the model of GnRH deficiency. Sci Transl Med. 2010 May 19; 2(32):32rv2. PMID: 20484732.
    Citations: 16     Fields:    Translation:HumansAnimals
  61. Seminara S, Nanni L, Generoso M, Mirri S, Leonardi V, Slabadzianiuk T, Vetrano ML, Buongiorno A, Losi S, Galluzzi F. Effect of treatment with cyproterone acetate on uterine bleeding at the beginning of GnRH analogue therapy in girls with idiopathic central precocious puberty. Horm Res Paediatr. 2010; 73(5):386-9. PMID: 20389110.
    Citations: 1     Fields:    Translation:Humans
  62. Chan YM, Fenoglio-Simeone KA, Paraschos S, Muhammad L, Troester MM, Ng YT, Johnsonbaugh RE, Coons SW, Prenger EC, Kerrigan JF, Seminara SB. Central precocious puberty due to hypothalamic hamartomas correlates with anatomic features but not with expression of GnRH, TGFalpha, or KISS1. Horm Res Paediatr. 2010; 73(5):312-9. PMID: 20389100.
    Citations: 4     Fields:    Translation:Humans
  63. Gianetti E, Tusset C, Noel SD, Au MG, Dwyer AA, Hughes VA, Abreu AP, Carroll J, Trarbach E, Silveira LF, Costa EM, de Mendonça BB, de Castro M, Lofrano A, Hall JE, Bolu E, Ozata M, Quinton R, Amory JK, Stewart SE, Arlt W, Cole TR, Crowley WF, Kaiser UB, Latronico AC, Seminara SB. TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. J Clin Endocrinol Metab. 2010 Jun; 95(6):2857-67. PMID: 20332248.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  64. Miura K, Miura S, Yoshiura K, Seminara S, Hamaguchi D, Niikawa N, Masuzaki H. A case of Kallmann syndrome carrying a missense mutation in alternatively spliced exon 8A encoding the immunoglobulin-like domain IIIb of fibroblast growth factor receptor 1. Hum Reprod. 2010 Apr; 25(4):1076-80. PMID: 20139426.
    Citations: 1     Fields:    Translation:HumansCells
  65. Chan YM, Broder-Fingert SB, Wong K, Seminara SB. Kisspeptin/Gpr54-independent GnRH activity in Kiss1 and Gpr54 mutant mice. J Neuroendocrinology. 2009; epub.
  66. Chan YM, Broder-Fingert S, Wong KM, Seminara SB. Kisspeptin/Gpr54-independent gonadotrophin-releasing hormone activity in Kiss1 and Gpr54 mutant mice. J Neuroendocrinol. 2009 Dec; 21(12):1015-23. PMID: 19840236.
    Citations: 36     Fields:    Translation:Animals
  67. Chan YM, Fenoglio KA, Paraschos S, Muhammad L, Troester MM, Ng YT, Johnsonbaugh RE, Coons SW, Prenger EC, Kerrigan JF, Seminara SB. Precocious puberty associated with hypothalamic hamartomas correlates with anatomic features but not with expression of GnRH, TGFá, or KISS1. Hormone Research. 2009; (In press).
  68. Chan YM, de Guillebon A, Lang-Muritano M, Plummer L, Cerrato F, Tsiaras S, Gaspert A, Lavoie HB, Wu CH, Crowley WF, Amory JK, Pitteloud N, Seminara SB. GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A. 2009 Jul 14; 106(28):11703-8. PMID: 19567835.
    Citations: 51     Fields:    Translation:HumansCells
  69. Jongmans MC, van Ravenswaaij-Arts CM, Pitteloud N, Ogata T, Sato N, Claahsen-van der Grinten HL, van der Donk K, Seminara S, Bergman JE, Brunner HG, Crowley WF, Hoefsloot LH. CHD7 mutations in patients initially diagnosed with Kallmann syndrome--the clinical overlap with CHARGE syndrome. Clin Genet. 2009 Jan; 75(1):65-71. PMID: 19021638.
    Citations: 55     Fields:    Translation:Humans
  70. Seminara SB. Lack of association of hypogonadotropic genes with age at menarche: prospects for the future. J Clin Endocrinol Metab. 2008 Nov; 93(11):4224-5. PMID: 18987281.
    Citations:    Fields:    Translation:Humans
  71. Chan YM, Broder-Fingert S, Seminara SB. Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men. Peptides. 2009 Jan; 30(1):42-8. PMID: 18644412.
    Citations: 10     Fields:    Translation:HumansAnimals
  72. Cole LW, Sidis Y, Zhang C, Quinton R, Plummer L, Pignatelli D, Hughes VA, Dwyer AA, Raivio T, Hayes FJ, Seminara SB, Huot C, Alos N, Speiser P, Takeshita A, Van Vliet G, Pearce S, Crowley WF, Zhou QY, Pitteloud N. Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum. J Clin Endocrinol Metab. 2008 Sep; 93(9):3551-9. PMID: 18559922.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  73. Cole LW, Sidis Y, Zhang C, Quinton R, Plummer L, Pignatelli D, Hughes VA, Dwyer AA, Raivio T, Hayes FJ, Seminara SB, Huot C, Alos N, Speiser P, Takeshita A, Van Vliet G, Pearce S, Crowley WF Jr, Zhou QY, Pitteloud N. Mutations in prokineticin 2(PROK2) and PROK2 receptor (PROKR2) in human gonadotropin-releasing hormone deficiency: molecular genetics and clinical spectrum. J Clin Endocrinol Metab. 2008; 93(9):3551-9.
  74. Seminara SB, Crowley WF. Kisspeptin and GPR54: discovery of a novel pathway in reproduction. J Neuroendocrinol. 2008 Jun; 20(6):727-31. PMID: 18601695.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  75. Gianetti E, Seminara S. Kisspeptin and KISS1R: a critical pathway in the reproductive system. Reproduction. 2008 Sep; 136(3):295-301. PMID: 18515314.
    Citations: 12     Fields:    Translation:HumansAnimals
  76. Teles MG, Bianco SD, Brito VN, Trarbach EB, Kuohung W, Xu S, Seminara SB, Mendonca BB, Kaiser UB, Latronico AC. A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med. 2008 Feb 14; 358(7):709-15. PMID: 18272894.
    Citations: 107     Fields:    Translation:HumansCells
  77. Teles MG, Bianco SDC, Brito VN, Trarbach E, Kuohung W, Xu S, Seminara SB, Mendonca B, Kaiser UB, Latronico AC. A GPR54 activating mutation is associated with gonadotropin dependent precocious puberty. N Engl J Med. 2008; 358(7):709-715.
  78. Crowley WF, Pitteloud N, Seminara S. New genes controlling human reproduction and how you find them. Trans Am Clin Climatol Assoc. 2008; 119:29-37; discussion 37-8. PMID: 18596868.
    Citations: 9     Fields:    Translation:HumansAnimals
  79. Seminara SB. Converging at puberty's hub. Endocrinology. 2007 Nov; 148(11):5145-6. PMID: 17940187.
    Citations: 2     Fields:    Translation:Animals
  80. Hughes VA, Boepple PA, Crowley WF, Seminara SB. Interplay between dose and frequency of GnRH administration in determining pituitary gonadotropin responsiveness. Neuroendocrinology. 2008; 87(3):142-50. PMID: 18063854.
    Citations: 4     Fields:    Translation:Humans
  81. Seminara SB. Kisspeptin in reproduction. Semin Reprod Med. 2007 Sep; 25(5):337-43. PMID: 17710729.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  82. Lapatto R, Pallais JC, Zhang D, Chan YM, Mahan A, Cerrato F, Le WW, Hoffman GE, Seminara SB. Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice. Endocrinology. 2007 Oct; 148(10):4927-36. PMID: 17595229.
    Citations: 153     Fields:    Translation:AnimalsCells
  83. Ramaswamy S, Seminara SB, Pohl CR, DiPietro MJ, Crowley WF, Plant TM. Effect of continuous intravenous administration of human metastin 45-54 on the neuroendocrine activity of the hypothalamic-pituitary-testicular axis in the adult male rhesus monkey (Macaca mulatta). Endocrinology. 2007 Jul; 148(7):3364-70. PMID: 17412800.
    Citations: 41     Fields:    Translation:HumansAnimals
  84. Cerrato F, Seminara SB. Human genetics of GPR54. Rev Endocr Metab Disord. 2007 Mar; 8(1):47-55. PMID: 17334928.
    Citations: 4     Fields:    Translation:Humans
  85. Pitteloud N, Quinton R, Pearce S, Raivio T, Acierno J, Dwyer A, Plummer L, Hughes V, Seminara S, Cheng YZ, Li WP, Maccoll G, Eliseenkova AV, Olsen SK, Ibrahimi OA, Hayes FJ, Boepple P, Hall JE, Bouloux P, Mohammadi M, Crowley W. Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism. J Clin Invest. 2007 Feb; 117(2):457-63. PMID: 17235395.
    Citations: 126     Fields:    Translation:HumansCells
  86. Timmons M, Tsokos M, Asab MA, Seminara SB, Zirzow GC, Kaneski CR, Heiss JD, van der Knaap MS, Vanier MT, Schiffmann R, Wong K. Peripheral and central hypomyelination with hypogonadotropic hypogonadism and hypodontia. Neurology. 2006 Dec 12; 67(11):2066-9. PMID: 17159124.
    Citations: 18     Fields:    Translation:Humans
  87. Cerrato F, Shagoury J, Kralickova M, Dwyer A, Falardeau J, Ozata M, Van Vliet G, Bouloux P, Hall JE, Hayes FJ, Pitteloud N, Martin KA, Welt C, Seminara SB. Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism. Eur J Endocrinol. 2006 Nov; 155 Suppl 1:S3-S10. PMID: 17074994.
    Citations: 22     Fields:    Translation:Humans
  88. Cerrato F, Shagoury J, Beranova M, Dwyer A, Falardeau J, Ozata M, VanVliet G, Bouloux PM, Hall JE, Hayes FJ, Pitteloud N, Welt C, Seminara SB. Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult onset forms of hypogonadotropic hypogonadism. Euro J Endocrinol. 2006; 155:S3-S10.
  89. Pitteloud N, Meysing A, Quinton R, Acierno JS, Dwyer AA, Plummer L, Fliers E, Boepple P, Hayes F, Seminara S, Hughes VA, Ma J, Bouloux P, Mohammadi M, Crowley WF. Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes. Mol Cell Endocrinol. 2006 Jul 25; 254-255:60-9. PMID: 16764984.
    Citations: 52     Fields:    Translation:Humans
  90. Pallais JC, Bo-Abbas Y, Pitteloud N, Crowley WF, Seminara SB. Neuroendocrine, gonadal, placental, and obstetric phenotypes in patients with IHH and mutations in the G-protein coupled receptor, GPR54. Mol Cell Endocrinol. 2006 Jul 25; 254-255:70-7. PMID: 16757106.
    Citations: 21     Fields:    Translation:Humans
  91. Seminara SB. Mechanisms of Disease: the first kiss-a crucial role for kisspeptin-1 and its receptor, G-protein-coupled receptor 54, in puberty and reproduction. Nat Clin Pract Endocrinol Metab. 2006 Jun; 2(6):328-34. PMID: 16932310.
    Citations: 12     Fields:    Translation:HumansAnimals
  92. Seminara SB. Mechanisms of disease: the first kiss--a crucial role for kisspeptin-1 and its receptor, G protein coupled receptor 54, in puberty and reproduction. Nature Clin Pract Endocrinol Med. 2006; 2(6):328-334.
  93. Seminara SB, Dipietro MJ, Ramaswamy S, Crowley WF, Plant TM. Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications. Endocrinology. 2006 May; 147(5):2122-6. PMID: 16469799.
    Citations: 64     Fields:    Translation:HumansAnimals
  94. Seminara SB. We all remember our first kiss: kisspeptin and the male gonadal axis. J Clin Endocrinol Metab. 2005 Dec; 90(12):6738-40. PMID: 16330809.
    Citations: 4     Fields:    Translation:HumansAnimals
  95. Seminara S, Stagi S, Candura L, Scrivano M, Lenzi L, Nanni L, Pagliai F, Chiarelli F. Changes of thyroid function during long-term hGH therapy in GHD children. A possible relationship with catch-up growth? Horm Metab Res. 2005 Dec; 37(12):751-6. PMID: 16372229.
    Citations: 4     Fields:    Translation:Humans
  96. Seminara SB. Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion. Front Neuroendocrinol. 2005 Oct-Dec; 26(3-4):131-8. PMID: 16309735.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  97. Corssmit EP, Seminara SB, Pitteloud N, Fliers E. Kallmann syndrome in a 47,XXX patient. Am J Med Genet A. 2005 Nov 15; 139(1):52-3. PMID: 16222664.
    Citations:    Fields:    Translation:HumansCells
  98. Kim HG, Herrick SR, Lemyre E, Kishikawa S, Salisz JA, Seminara S, MacDonald ME, Bruns GA, Morton CC, Quade BJ, Gusella JF. Hypogonadotropic hypogonadism and cleft lip and palate caused by a balanced translocation producing haploinsufficiency for FGFR1. J Med Genet. 2005 Aug; 42(8):666-72. PMID: 16061567.
    Citations: 23     Fields:    Translation:HumansCells
  99. Seminara SB, Kaiser UB. New gatekeepers of reproduction: GPR54 and its cognate ligand, KiSS-1. Endocrinology. 2005 Apr; 146(4):1686-8. PMID: 15769900.
    Citations: 7     Fields:    Translation:Animals
  100. Shahab M, Mastronardi C, Seminara SB, Crowley WF, Ojeda SR, Plant TM. Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2129-34. PMID: 15684075.
    Citations: 205     Fields:    Translation:HumansAnimalsCells
  101. Meysing AU, Kanasaki H, Bedecarrats GY, Acierno JS, Conn PM, Martin KA, Seminara SB, Hall JE, Crowley WF, Kaiser UB. GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone. J Clin Endocrinol Metab. 2004 Jul; 89(7):3189-98. PMID: 15240592.
    Citations: 17     Fields:    Translation:HumansCells
  102. Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA. A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology. 2004 Sep; 145(9):4073-7. PMID: 15217982.
    Citations: 274     Fields:    Translation:Animals
  103. Seminara SB. Learning from the Literature. 2004.
  104. Seminara S, McMahon,G. Transcript & Tutor Guide "Pumped Up". 2004.
  105. Miura K, Acierno JS, Seminara SB. Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH). J Hum Genet. 2004; 49(5):265-8. PMID: 15362570.
    Citations: 31     Fields:    Translation:HumansCells
  106. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF, Aparicio SA, Colledge WH. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003 Oct 23; 349(17):1614-27. PMID: 14573733.
    Citations: 573     Fields:    Translation:HumansAnimals
  107. Bédécarrats GY, Linher KD, Janovick JA, Beranova M, Kada F, Seminara SB, Michael Conn P, Kaiser UB. Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor function. Mol Cell Endocrinol. 2003 Jul 31; 205(1-2):51-64. PMID: 12890567.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  108. Acierno JS, Shagoury JK, Bo-Abbas Y, Crowley WF, Seminara SB. A locus for autosomal recessive idiopathic hypogonadotropic hypogonadism on chromosome 19p13.3. J Clin Endocrinol Metab. 2003 Jun; 88(6):2947-50. PMID: 12788910.
    Citations: 4     Fields:    Translation:HumansCells
  109. Bo-Abbas Y, Acierno JS, Shagoury JK, Crowley WF, Seminara SB. Autosomal recessive idiopathic hypogonadotropic hypogonadism: genetic analysis excludes mutations in the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes. J Clin Endocrinol Metab. 2003 Jun; 88(6):2730-7. PMID: 12788881.
    Citations: 14     Fields:    Translation:Humans
  110. Seminara SB, Crowley WF. Genetic approaches to unraveling reproductive disorders: examples of bedside to bench research in the genomic era. Endocr Rev. 2002 Jun; 23(3):382-92. PMID: 12050127.
    Citations: 3     Fields:    Translation:Humans
  111. Seminara SB, Acierno JS, Abdulwahid NA, Crowley WF, Margolin DH. Hypogonadotropic hypogonadism and cerebellar ataxia: detailed phenotypic characterization of a large, extended kindred. J Clin Endocrinol Metab. 2002 Apr; 87(4):1607-12. PMID: 11932290.
    Citations: 13     Fields:    Translation:Humans
  112. Pitteloud N, Hayes FJ, Boepple PA, DeCruz S, Seminara SB, MacLaughlin DT, Crowley WF. The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2002 Jan; 87(1):152-60. PMID: 11788640.
    Citations: 32     Fields:    Translation:Humans
  113. Seminara S, Crowley WF. The genetics of IHH--a paradox. Clin Endocrinol (Oxf). 2001 Aug; 55(2):159-60. PMID: 11531920.
    Citations:    Fields:    Translation:HumansCells
  114. Seminara SB, Crowley WF. Perspective: the importance of genetic defects in humans in elucidating the complexities of the hypothalamic-pituitary-gonadal axis. Endocrinology. 2001 Jun; 142(6):2173-7. PMID: 11356659.
    Citations: 11     Fields:    Translation:HumansAnimals
  115. Beranova M, Oliveira LM, Bédécarrats GY, Schipani E, Vallejo M, Ammini AC, Quintos JB, Hall JE, Martin KA, Hayes FJ, Pitteloud N, Kaiser UB, Crowley WF, Seminara SB. Prevalence, phenotypic spectrum, and modes of inheritance of gonadotropin-releasing hormone receptor mutations in idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2001 Apr; 86(4):1580-8. PMID: 11297587.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  116. Oliveira LM, Seminara SB, Beranova M, Hayes FJ, Valkenburgh SB, Schipani E, Costa EM, Latronico AC, Crowley WF, Vallejo M. The importance of autosomal genes in Kallmann syndrome: genotype-phenotype correlations and neuroendocrine characteristics. J Clin Endocrinol Metab. 2001 Apr; 86(4):1532-8. PMID: 11297579.
    Citations: 43     Fields:    Translation:Humans
  117. Hayes FJ, DeCruz S, Seminara SB, Boepple PA, Crowley WF. Differential regulation of gonadotropin secretion by testosterone in the human male: absence of a negative feedback effect of testosterone on follicle-stimulating hormone secretion. J Clin Endocrinol Metab. 2001 Jan; 86(1):53-8. PMID: 11231978.
    Citations: 25     Fields:    Translation:Humans
  118. Seminara SB, Hall JE. Physicians' Information and Education Resource (PIER). 2001.
  119. Seminara SB, Oliveira LM, Beranova M, Hayes FJ, Crowley WF. Genetics of hypogonadotropic hypogonadism. J Endocrinol Invest. 2000 Oct; 23(9):560-5. PMID: 11079449.
    Citations: 7     Fields:    Translation:Humans
  120. Hayes FJ, Seminara SB, Decruz S, Boepple PA, Crowley WF. Aromatase inhibition in the human male reveals a hypothalamic site of estrogen feedback. J Clin Endocrinol Metab. 2000 Sep; 85(9):3027-35. PMID: 10999781.
    Citations: 35     Fields:    Translation:HumansCTClinical Trials
  121. Seminara SB, Beranova M, Oliveira LM, Martin KA, Crowley WF, Hall JE. Successful use of pulsatile gonadotropin-releasing hormone (GnRH) for ovulation induction and pregnancy in a patient with GnRH receptor mutations. J Clin Endocrinol Metab. 2000 Feb; 85(2):556-62. PMID: 10690855.
    Citations: 24     Fields:    Translation:HumansCells
  122. Seminara S, Rapisardi G, La Cauza F, Mattei P, Donzelli G. Catch-up growth in short-at-birth NICU graduates. Horm Res. 2000; 53(3):139-43. PMID: 11044794.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  123. Seminara SB, Achermann JC, Genel M, Jameson JL, Crowley WF. X-linked adrenal hypoplasia congenita: a mutation in DAX1 expands the phenotypic spectrum in males and females. J Clin Endocrinol Metab. 1999 Dec; 84(12):4501-9. PMID: 10599709.
    Citations: 27     Fields:    Translation:HumansCells
  124. Achermann JC, Gu WX, Kotlar TJ, Meeks JJ, Sabacan LP, Seminara SB, Habiby RL, Hindmarsh PC, Bick DP, Sherins RJ, Crowley WF, Layman LC, Jameson JL. Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay. J Clin Endocrinol Metab. 1999 Dec; 84(12):4497-500. PMID: 10599708.
    Citations: 11     Fields:    Translation:HumansCells
  125. Seminara S, Crowley WF. Hypogonadotrophic hypogonadism: a unique biological opportunity. Clin Endocrinol (Oxf). 1999 Oct; 51(4):385-6. PMID: 10583302.
    Citations:    Fields:    Translation:Humans
  126. Seminara SB, Hall JE, Taylor AE, Crowley WF, Martin KA. The Reproductive Endocrine Associates of the Massachusetts General Hospital: fifteen years of integrated clinical practice and investigation. J Clin Endocrinol Metab. 1999 Jun; 84(6):1912-8. PMID: 10372686.
    Citations:    Fields:    Translation:Humans
  127. Seminara SB, Crowley Jr WF. Hypogonadotropic hypogonadism: A unique biologic opportunity. Clin Endocrinol. 1999; 51:385-386.
  128. Hayes FJ, Seminara SB, Crowley WF. Hypogonadotropic hypogonadism. Endocrinol Metab Clin North Am. 1998 Dec; 27(4):739-63, vii. PMID: 9922906.
    Citations: 11     Fields:    Translation:HumansAnimals
  129. Seminara SB, Hayes FJ, Crowley WF. Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann's syndrome): pathophysiological and genetic considerations. Endocr Rev. 1998 Oct; 19(5):521-39. PMID: 9793755.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  130. Seminara S, Filpo A, La Cauza F, Faedda A, Miola A, Pellizzone S, Casati M, Loche S. Growth hormone binding protein activity in obese children. J Endocrinol Invest. 1998 Jul-Aug; 21(7):441-4. PMID: 9766258.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  131. Seminara S, Merello G, Masi S, Filpo A, La Cauza F, D'Onghia G, Martelli E, Loche S. Effect of long-term growth hormone treatment on carbohydrate metabolism in children with growth hormone deficiency. Clin Endocrinol (Oxf). 1998 Jul; 49(1):125-30. PMID: 9797856.
    Citations: 7     Fields:    Translation:HumansCells
  132. Seminara SB, Daniels GH. Amiodarone and the thyroid. Endocr Pract. 1998 Jan-Feb; 4(1):48-57. PMID: 15251765.
    Citations: 2     Fields:    
  133. Seminara S, Filpo A, Piccinini P, La Cauza F, Cappa M, Faedda A, Loche S. Growth hormone (GH) response to GH-releasing hormone in short children: lack of correlation with endogenous nocturnal GH secretion. J Endocrinol Invest. 1997 Mar; 20(3):118-21. PMID: 9186816.
    Citations: 2     Fields:    Translation:Humans
  134. Waldstreicher J, Seminara SB, Jameson JL, Geyer A, Nachtigall LB, Boepple PA, Holmes LB, Crowley WF. The genetic and clinical heterogeneity of gonadotropin-releasing hormone deficiency in the human. J Clin Endocrinol Metab. 1996 Dec; 81(12):4388-95. PMID: 8954047.
    Citations: 21     Fields:    Translation:HumansCells
  135. Bellone J, Aimaretti G, Valetto MR, Bellone S, Baffoni C, Arvat E, Seminara S, Camanni F, Ghigo E. Acute administration of recombinant human growth hormone inhibits the somatotrope responsiveness to growth hormone-releasing hormone in childhood. Eur J Endocrinol. 1996 Oct; 135(4):421-4. PMID: 8921823.
    Citations: 2     Fields:    Translation:Humans
  136. Seminara SB, Boepple PA, Nachtigall LB, Pralong FP, Khoury RH, Sluss PM, Lecain AE, Crowley WF. Inhibin B in males with gonadotropin-releasing hormone (GnRH) deficiency: changes in serum concentration after shortterm physiologic GnRH replacement--a clinical research center study. J Clin Endocrinol Metab. 1996 Oct; 81(10):3692-6. PMID: 8855824.
    Citations: 5     Fields:    Translation:Humans
  137. Nachtigall LB, Boepple PA, Seminara SB, Khoury RH, Sluss PM, Lecain AE, Crowley WF. Inhibin B secretion in males with gonadotropin-releasing hormone (GnRH) deficiency before and during long-term GnRH replacement: relationship to spontaneous puberty, testicular volume, and prior treatment--a clinical research center study. J Clin Endocrinol Metab. 1996 Oct; 81(10):3520-5. PMID: 8855795.
    Citations: 6     Fields:    Translation:Humans
  138. Seminara SB, Dryja TP. Unbiased transmission of mutant alleles at the human retinoblastoma locus. Hum Genet. 1994 Jun; 93(6):629-34. PMID: 8005586.
    Citations: 5     Fields:    Translation:Humans
  139. Pittari AM, Becherucci P, La Cauza F, Seminara S. [Therapy with arginine chlorohydrate in children with short constitutional stature]. Minerva Pediatr. 1993 Jan-Feb; 45(1-2):61-5. PMID: 8316165.
    Citations:    Fields:    Translation:Humans
  140. Becherucci P, Seminara S, Paoletti I, Galluzzi F, Martinucci ME, Medici A, Parpagnoli M, Toni S, Bernardini S, Chiccoli A. Thyroid hormones low levels in insulin-dependent diabetic young people. J Endocrinol Invest. 1989; 12(8 Suppl 3):151-2. PMID: 2809095.
    Citations:    Fields:    Translation:Humans
  141. Seminara S, Galluzzi F, Salti R, Generoso M, Bini A, Brocchi A, Alessandrello AL. Serum and urine somatomedin B in pediatrics. Ric Clin Lab. 1984 Jan-Mar; 14(1):41-6. PMID: 6729353.
    Citations:    Fields:    Translation:Humans
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Seminara's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (388)
Co-Authors (54)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.