Harvard Catalyst Profiles

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Hyun-Sik Yang, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K23AG062750 (YANG, HYUN-SIK) Apr 15, 2019 - Feb 29, 2024
    Immunogenetic contribution to the progression of preclinical Alzheimer's disease
    Role: Principal Investigator
  2. AACF-17-505359 (YANG, HYUN-SIK) May 1, 2017 - Apr 30, 2019
    Alzheimer's Association
    Pathophysiologic link between TDP-43 pathology and Alzheimer’s disease
    Role: Principle Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Eissman JM, Dumitrescu L, Mahoney ER, Smith AN, Mukherjee S, Lee ML, Scollard P, Choi SE, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski CC, Hernandez Saucedo H, Widaman KF, Buckley RF, Properzi MJ, Mormino EC, Yang HS, Harrison TM, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Zhong X, Raghavan NS, Vardarajan BN, Pericak-Vance MA, Farrer LA, Wang LS, Cruchaga C, Schellenberg GD, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Cuccaro ML, Bennett DA, Schneider JA, Crane PK, Jefferson AL, Hohman TJ. Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease. Brain. 2022 07 29; 145(7):2541-2554. PMID: 35552371; PMCID: PMC9337804.
    Citations: 1     Fields:    
  2. Yang HS. Human Genetics Clarifies the Relationship Between Depression and Alzheimer's Disease. Biol Psychiatry. 2022 07 01; 92(1):2-4. PMID: 35710160.
    Citations:    Fields:    Translation:Humans
  3. Rabin JS, Pruzin J, Scott M, Yang HS, Hampton O, Hsieh S, Schultz AP, Buckley RF, Hedden T, Rentz D, Johnson KA, Sperling RA, Chhatwal JP. Association of ß-Amyloid and Vascular Risk on Longitudinal Patterns of Brain Atrophy. Neurology. 2022 Apr 26. PMID: 35473760; PMCID: PMC9302937.
    Citations:    Fields:    
  4. Wingo AP, Wang M, Liu J, Breen MS, Yang HS, Tang B, Schneider JA, Seyfried NT, Lah JJ, Levey AI, Bennett DA, Jin P, De Jager PL, Wingo TS. Brain microRNAs are associated with variation in cognitive trajectory in advanced age. Transl Psychiatry. 2022 02 01; 12(1):47. PMID: 35105862; PMCID: PMC8807720.
    Citations: 1     Fields:    Translation:Humans
  5. Klein HU, Trumpff C, Yang HS, Lee AJ, Picard M, Bennett DA, De Jager PL. Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer's disease brain. Mol Neurodegener. 2021 11 06; 16(1):75. PMID: 34742335.
    Citations: 8     Fields:    Translation:HumansCells
  6. Yang HS, Zhang C, Carlyle BC, Zhen SY, Trombetta BA, Schultz AP, Pruzin JJ, Fitzpatrick CD, Yau WW, Kirn DR, Rentz DM, Arnold SE, Johnson KA, Sperling RA, Chhatwal JP, Tanzi RE. Plasma IL-12/IFN-? axis predicts cognitive trajectories in cognitively unimpaired older adults. Alzheimers Dement. 2022 04; 18(4):645-653. PMID: 34160128; PMCID: PMC8695625.
    Citations: 7     Fields:    Translation:Humans
  7. Belloy ME, Eger SJ, Le Guen Y, Napolioni V, Deters KD, Yang HS, Scelsi MA, Porter T, James SN, Wong A, Schott JM, Sperling RA, Laws SM, Mormino EC, He Z, Han SS, Altmann A, Greicius MD. KL*VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE*4 carriers. Neurobiol Aging. 2021 05; 101:123-129. PMID: 33610961; PMCID: PMC8122023.
    Citations: 2     Fields:    Translation:Humans
  8. Chhatwal JP, Schultz AP, Dang Y, Ostaszewski B, Liu L, Yang HS, Johnson KA, Sperling RA, Selkoe DJ. Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals. Nat Commun. 2020 11 27; 11(1):6024. PMID: 33247134; PMCID: PMC7695712.
    Citations: 9     Fields:    Translation:Humans
  9. Raghavan NS, Dumitrescu L, Mormino E, Mahoney ER, Lee AJ, Gao Y, Bilgel M, Goldstein D, Harrison T, Engelman CD, Saykin AJ, Whelan CD, Liu JZ, Jagust W, Albert M, Johnson SC, Yang HS, Johnson K, Aisen P, Resnick SM, Sperling R, De Jager PL, Schneider J, Bennett DA, Schrag M, Vardarajan B, Hohman TJ, Mayeux R. Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease. JAMA Neurol. 2020 10 01; 77(10):1288-1298. PMID: 32568366; PMCID: PMC7309575.
    Citations: 13     Fields:    Translation:Humans
  10. Ouellette AR, Neuner SM, Dumitrescu L, Anderson LC, Gatti DM, Mahoney ER, Bubier JA, Churchill G, Peters L, Huentelman MJ, Herskowitz JH, Yang HS, Smith AN, Reitz C, Kunkle BW, White CC, De Jager PL, Schneider JA, Bennett DA, Seyfried NT, Chesler EJ, Hadad N, Hohman TJ, Kaczorowski CC. Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia. Cell Rep. 2020 09 01; 32(9):108091. PMID: 32877673; PMCID: PMC7502175.
    Citations: 6     Fields:    Translation:Humans
  11. Dumitrescu L, Mahoney ER, Mukherjee S, Lee ML, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski C, Hernandez Saucedo H, Widaman KF, Buckley R, Properzi M, Mormino E, Yang HS, Harrison T, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Moore AM, Cambronero F, Zhong X, Raghavan NS, Vardarajan B, Pericak-Vance MA, Farrer LA, Wang LS, Cruchaga C, Schellenberg G, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Bennett DA, Schneider JA, Crane PK, Jefferson AL, Hohman TJ. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain. 2020 08 01; 143(8):2561-2575. PMID: 32844198; PMCID: PMC7447518.
    Citations: 22     Fields:    Translation:HumansCells
  12. Yang HS, White CC, Klein HU, Yu L, Gaiteri C, Ma Y, Felsky D, Mostafavi S, Petyuk VA, Sperling RA, Ertekin-Taner N, Schneider JA, Bennett DA, De Jager PL. Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology. Neuron. 2020 08 05; 107(3):496-508.e6. PMID: 32526197.
    Citations: 11     Fields:    Translation:HumansCells
  13. Rabin JS, Shirzadi Z, Swardfager W, MacIntosh BJ, Schultz A, Yang HS, Buckley RF, Gatchel JR, Kirn D, Pruzin JJ, Hedden T, Lipsman N, Rentz DM, Black SE, Johnson KA, Sperling RA, Chhatwal JP. Amyloid-beta burden predicts prospective decline in body mass index in clinically normal adults. Neurobiol Aging. 2020 09; 93:124-130. PMID: 32249013.
    Citations: 6     Fields:    Translation:Humans
  14. Schultz AP, Buckley RF, Hampton OL, Scott MR, Properzi MJ, Peña-Gómez C, Pruzin JJ, Yang HS, Johnson KA, Sperling RA, Chhatwal JP. Longitudinal degradation of the default/salience network axis in symptomatic individuals with elevated amyloid burden. Neuroimage Clin. 2020; 26:102052. PMID: 31711955.
    Citations: 6     Fields:    Translation:Humans
  15. Rabin JS, Klein H, Kirn DR, Schultz AP, Yang HS, Hampton O, Jiang S, Buckley RF, Viswanathan A, Hedden T, Pruzin J, Yau WW, Guzmán-Vélez E, Quiroz YT, Properzi M, Marshall GA, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Associations of Physical Activity and ß-Amyloid With Longitudinal Cognition and Neurodegeneration in Clinically Normal Older Adults. JAMA Neurol. 2019 Oct 01; 76(10):1203-1210. PMID: 31312836; PMCID: PMC6635892.
    Citations: 25     Fields:    
  16. Gatchel JR, Rabin JS, Buckley RF, Locascio JJ, Quiroz YT, Yang HS, Vannini P, Amariglio RE, Rentz DM, Properzi M, Donovan NJ, Blacker D, Johnson KA, Sperling RA, Marshall GA. Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults. JAMA Netw Open. 2019 08 02; 2(8):e198964. PMID: 31397865.
    Citations: 24     Fields:    Translation:Humans
  17. Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, Hanseeuw BJ, Buckley R, Chhatwal J, Hedden T, Marshall GA, Quiroz YT, Donovan NJ, Jackson J, Gatchel JR, Rabin JS, Jacobs H, Yang HS, Properzi M, Kirn DR, Rentz DM, Johnson KA. The impact of amyloid-beta and tau on prospective cognitive decline in older individuals. Ann Neurol. 2019 02; 85(2):181-193. PMID: 30549303.
    Citations: 68     Fields:    Translation:Humans
  18. Rabin JS, Yang HS, Schultz AP, Hanseeuw BJ, Hedden T, Viswanathan A, Gatchel JR, Marshall GA, Kilpatrick E, Klein H, Rao V, Buckley RF, Yau WW, Kirn DR, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Vascular Risk and ß-Amyloid Are Synergistically Associated with Cortical Tau. Ann Neurol. 2019 02; 85(2):272-279. PMID: 30565287.
    Citations: 33     Fields:    Translation:Humans
  19. Yang HS, Chhatwal JP, Xu J, White CC, Hanseeuw B, Rabin JS, Papp KV, Buckley RF, Schultz AP, Properzi MJ, Gatchel JR, Amariglio RE, Donovan NJ, Mormino EC, Hedden T, Marshall GA, Rentz DM, Johnson KA, De Jager PL, Sperling RA. An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults. J Alzheimers Dis. 2019; 68(3):1161-1170. PMID: 30883345; PMCID: PMC6571137.
    Citations: 1     Fields:    Translation:Humans
  20. Sepulcre J, Grothe MJ, d'Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang HS, Jacobs HIL, Hanseeuw BJ, Li Q, El-Fakhri G, Sperling RA, Johnson KA. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nat Med. 2018 12; 24(12):1910-1918. PMID: 30374196; PMCID: PMC6518398.
    Citations: 53     Fields:    Translation:HumansCells
  21. De Jager PL, Yang HS, Bennett DA. Deconstructing and targeting the genomic architecture of human neurodegeneration. Nat Neurosci. 2018 10; 21(10):1310-1317. PMID: 30258235.
    Citations: 19     Fields:    Translation:Humans
  22. Rabin JS, Schultz AP, Hedden T, Viswanathan A, Marshall GA, Kilpatrick E, Klein H, Buckley RF, Yang HS, Properzi M, Rao V, Kirn DR, Papp KV, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Interactive Associations of Vascular Risk and ß-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study. JAMA Neurol. 2018 09 01; 75(9):1124-1131. PMID: 29799986; PMCID: PMC6143121.
    Citations: 70     Fields:    Translation:Humans
  23. Yang HS, Yu L, White CC, Chibnik LB, Chhatwal JP, Sperling RA, Bennett DA, Schneider JA, De Jager PL. Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE e4 haplotype status: a community-based cohort study. Lancet Neurol. 2018 09; 17(9):773-781. PMID: 30093249.
    Citations: 52     Fields:    Translation:HumansCells
  24. Colorado RA, Matiello M, Yang HS, Rabinov JD, Patel A, Hirsch JA, Chavali R, Leslie-Mazwi TM. Progressive Neurological Decline with Deep Bilateral Imaging Changes: A Protean Presentation of Dural Arteriovenous Fistulae. Interv Neurol. 2018 Apr; 7(5):256-264. PMID: 29765395; PMCID: PMC5939689.
    Citations: 1     
  25. Ajayi T, Yang HS, Bhatia A. Active 46-year-old man with right-sided visual loss and no family history of stroke · Dx? J Fam Pract. 2017 Aug; 66(8):507-509. PMID: 28783770.
    Citations:    Fields:    Translation:Humans
  26. Yang HS, White CC, Chibnik LB, Klein HU, Schneider JA, Bennett DA, De Jager PL. UNC5C variants are associated with cerebral amyloid angiopathy. Neurol Genet. 2017 Aug; 3(4):e176. PMID: 28761931; PMCID: PMC5515600.
    Citations: 6     
  27. White CC, Yang HS, Yu L, Chibnik LB, Dawe RJ, Yang J, Klein HU, Felsky D, Ramos-Miguel A, Arfanakis K, Honer WG, Sperling RA, Schneider JA, Bennett DA, De Jager PL. Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data. PLoS Med. 2017 04; 14(4):e1002287. PMID: 28441426; PMCID: PMC5404753.
    Citations: 41     Fields:    Translation:HumansCells
  28. Jordan JT, Yang HS, Narendra D, Plotkin SR. Teaching NeuroImages: brain mass with hilar adenopathy: the importance of histologic diagnosis. Neurology. 2014 May 06; 82(18):e161-2. PMID: 24799521.
    Citations:    Fields:    Translation:Humans
  29. Yang HS, Yoon C, Myung SK, Park SM. Effect of obesity on survival of women with epithelial ovarian cancer: a systematic review and meta-analysis of observational studies. Int J Gynecol Cancer. 2011 Dec; 21(9):1525-32. PMID: 22080892.
    Citations: 32     Fields:    Translation:Humans
  30. Yang HS, Kwon HG, Hong JH, Hong CP, Jang SH. The rubrospinal tract in the human brain: diffusion tensor imaging study. Neurosci Lett. 2011 Oct 17; 504(1):45-8. PMID: 21911039.
    Citations: 19     Fields:    Translation:Humans
  31. Yoon C, Yang HS, Jeon I, Chang Y, Park SM. Use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers and cancer risk: a meta-analysis of observational studies. CMAJ. 2011 Oct 04; 183(14):E1073-84. PMID: 21876027; PMCID: PMC3185099.
    Citations: 23     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.