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profileMalak S Abedalthagafi, M.B.,B.S.

TitleInstructor in Pathology, Part-time
InstitutionBrigham and Women's Hospital
DepartmentPathology
AddressBrigham and Women's Hospital
Pathology
75 Francis St
Boston MA 02115
Phone617/733-7503
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2015SciTec young professional award
2015Makkah prize in science and technology

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I am board certified in Clinical Pathology , Anatomical Pathology , Neuropathology, and Molecular Genetics Pathology. My clinical and research interests are mainly in surgical pathology, molecular genetics pathology and neuropathology, especially in terms of its application towards neuro-oncology. I am involved in multiple translational research projects to develop new diagnostic and prognostic molecular genomic markers for CNS tumors. We collaborate with multiple groups in Harvard community as well as non-Harvard researchers. Our hope is to improve the application of personalized medicine and targeted therapy , which can be utilized in the clinical management of brain tumor patients.


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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bi WL, Greenwald NF, Ramkissoon SH, Abedalthagafi M, Coy SM, Ligon KL, Mei Y, MacConaill L, Ducar M, Min L, Santagata S, Kaiser UB, Beroukhim R, Laws ER, Dunn IF. Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors. Endocrinology. 2017 Jul 01; 158(7):2284-2291. PMID: 28486603.
    View in: PubMed
  2. Bi WL, Greenwald NF, Abedalthagafi M, Wala J, Gibson WJ, Agarwalla PK, Horowitz P, Schumacher SE, Esaulova E, Mei Y, Chevalier A, Ducar M, Thorner AR, van Hummelen P, Stemmer-Rachamimov A, Artyomov M, Al-Mefty O, Dunn GP, Santagata S, Dunn IF, Beroukhim R. Genomic landscape of high-grade meningiomas. NPJ Genom Med. 2017; 2. PMID: 28713588.
    View in: PubMed
  3. Shankar GM, Abedalthagafi M, Vaubel RA, Merrill PH, Nayyar N, Gill CM, Brewster R, Bi WL, Agarwalla PK, Thorner AR, Reardon DA, Al-Mefty O, Wen PY, Alexander BM, van Hummelen P, Batchelor TT, Ligon KL, Ligon AH, Meyerson M, Dunn IF, Beroukhim R, Louis DN, Perry A, Carter SL, Giannini C, Curry WT, Cahill DP, Barker FG, Brastianos PK, Santagata S. Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas. Neuro Oncol. 2017 04 01; 19(4):535-545. PMID: 28170043.
    View in: PubMed
  4. Abedalthagafi M, Aldandan SW, Alrayis M, Ahmed AA. Lymph node metastasis of presacral ependymoblastoma in a young child. J Clin Neurosci. 2017 Jun; 40:64-66. PMID: 28215462.
    View in: PubMed
  5. Bi WL, Horowitz P, Greenwald NF, Abedalthagafi M, Agarwalla PK, Gibson WJ, Mei Y, Schumacher SE, Ben-David U, Chevalier A, Carter S, Tiao G, Brastianos PK, Ligon AH, Ducar M, MacConaill L, Laws ER, Santagata S, Beroukhim R, Dunn IF. Landscape of Genomic Alterations in Pituitary Adenomas. Clin Cancer Res. 2017 Apr 01; 23(7):1841-1851. PMID: 27707790.
    View in: PubMed
  6. Ahmed AA, Abedalthagafi M. Cancer diagnostics: The journey from histomorphology to molecular profiling. Oncotarget. 2016 09 06; 7(36):58696-58708. PMID: 27509178.
    View in: PubMed
  7. Bale TA, Abedalthagafi M, Bi WL, Kang YJ, Merrill P, Dunn IF, Dubuc A, Charbonneau SK, Brown L, Ligon AH, Ramkissoon SH, Ligon KL. Genomic characterization of recurrent high-grade astroblastoma. Cancer Genet. 2016 Jul-Aug; 209(7-8):321-30. PMID: 27425854.
    View in: PubMed
  8. Miller MB, Bi WL, Ramkissoon LA, Kang YJ, Abedalthagafi M, Knoff DS, Agarwalla PK, Wen PY, Reardon DA, Alexander BM, Laws ER, Dunn IF, Beroukhim R, Ligon KL, Ramkissoon SH. MAPK activation and HRAS mutation identified in pituitary spindle cell oncocytoma. Oncotarget. 2016 Jun 14; 7(24):37054-37063. PMID: 27175596.
    View in: PubMed
  9. Coroller T, Bi W, Abedalthagafi M, Aizer A, Wu W, Greenwald N, Beroukhim R, Al-Mefty O, Santagata S, Dunn I, Alexander B, Huang R, Aerts H. SU-D-207B-02: Early Grade Classification in Meningioma Patients Combining Radiomics and Semantics Data. Med Phys. 2016 Jun; 43(6):3348-3349. PMID: 28048264.
    View in: PubMed
  10. Abedalthagafi MS, Wu MP, Merrill PH, Du Z, Woo T, Sheu SH, Hurwitz S, Ligon KL, Santagata S. Decreased FOXJ1 expression and its ciliogenesis programme in aggressive ependymoma and choroid plexus tumours. J Pathol. 2016 Mar; 238(4):584-97. PMID: 26690880.
    View in: PubMed
  11. Abedalthagafi M, Bi WL, Aizer AA, Merrill PH, Brewster R, Agarwalla PK, Listewnik ML, Dias-Santagata D, Thorner AR, Van Hummelen P, Brastianos PK, Reardon DA, Wen PY, Al-Mefty O, Ramkissoon SH, Folkerth RD, Ligon KL, Ligon AH, Alexander BM, Dunn IF, Beroukhim R, Santagata S. Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma. Neuro Oncol. 2016 May; 18(5):649-55. PMID: 26826201; PMCID: PMC4827048 [Available on 05/01/17].
  12. Bi WL, Abedalthagafi M, Horowitz P, Agarwalla PK, Mei Y, Aizer AA, Brewster R, Dunn GP, Al-Mefty O, Alexander BM, Santagata S, Beroukhim R, Dunn IF. Genomic landscape of intracranial meningiomas. J Neurosurg. 2016 Sep; 125(3):525-35. PMID: 26771848.
    View in: PubMed
  13. Brastianos PK, Shankar GM, Gill CM, Taylor-Weiner A, Nayyar N, Panka DJ, Sullivan RJ, Frederick DT, Abedalthagafi M, Jones PS, Dunn IF, Nahed BV, Romero JM, Louis DN, Getz G, Cahill DP, Santagata S, Curry WT, Barker FG. Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy. J Natl Cancer Inst. 2016 Feb; 108(2). PMID: 26498373; PMCID: PMC4862417 [Available on 02/01/17].
  14. Zowawi HM, Abedalthagafi M, Mar FA, Almalki T, Kutbi AH, Harris-Brown T, Harbarth S, Balkhy HH, Paterson DL, Hasanain RA. The Potential Role of Social Media Platforms in Community Awareness of Antibiotic Use in the Gulf Cooperation Council States: Luxury or Necessity? J Med Internet Res. 2015 Oct 15; 17(10):e233. PMID: 26471079; PMCID: PMC4642378.
  15. Aizer AA, Abedalthagafi M, Bi WL, Horvath MC, Arvold ND, Al-Mefty O, Lee EQ, Nayak L, Rinne ML, Norden AD, Reardon DA, Wen PY, Ligon KL, Ligon AH, Beroukhim R, Dunn IF, Santagata S, Alexander BM. A prognostic cytogenetic scoring system to guide the adjuvant management of patients with atypical meningioma. Neuro Oncol. 2016 Feb; 18(2):269-74. PMID: 26323607; PMCID: PMC4724184 [Available on 02/01/17].
  16. Ahmed AA, Abedalthagafi M, Anwar AE, Bui MM. Akt and Hippo Pathways in Ewing's Sarcoma Tumors and Their Prognostic Significance. J Cancer. 2015; 6(10):1005-10. PMID: 26366214; PMCID: PMC4565850.
  17. Forsyth TM, Bi WL, Abedalthagafi M, Dunn IF, Chiocca EA. Extracranial growth of glioblastoma multiforme. J Clin Neurosci. 2015 Sep; 22(9):1521-3. PMID: 25956620.
    View in: PubMed
  18. Abedalthagafi MS, Bi WL, Merrill PH, Gibson WJ, Rose MF, Du Z, Francis JM, Du R, Dunn IF, Ligon AH, Beroukhim R, Santagata S. ARID1A and TERT promoter mutations in dedifferentiated meningioma. Cancer Genet. 2015 Jun; 208(6):345-50. PMID: 25963524; PMCID: PMC4882906.
  19. Bhattacharyya S, Wong JC, Abedalthagafi M, Wahlster S, Vaitkevicius H. Myelodysplastic syndrome with progressive multifocal predominantly pontine demyelination. Neurol Neuroimmunol Neuroinflamm. 2015 Jun; 2(3):e90. PMID: 25798451; PMCID: PMC4360795.
  20. Du Z, Abedalthagafi M, Aizer AA, McHenry AR, Sun HH, Bray MA, Viramontes O, Machaidze R, Brastianos PK, Reardon DA, Dunn IF, Freeman GJ, Ligon KL, Carpenter AE, Alexander BM, Agar NY, Rodig SJ, Bradshaw EM, Santagata S. Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma. Oncotarget. 2015 Mar 10; 6(7):4704-16. PMID: 25609200; PMCID: PMC4467109.
  21. Ramkissoon SH, Bi WL, Schumacher SE, Ramkissoon LA, Haidar S, Knoff D, Dubuc A, Brown L, Burns M, Cryan JB, Abedalthagafi M, Kang YJ, Schultz N, Reardon DA, Lee EQ, Rinne ML, Norden AD, Nayak L, Ruland S, Doherty LM, LaFrankie DC, Horvath M, Aizer AA, Russo A, Arvold ND, Claus EB, Al-Mefty O, Johnson MD, Golby AJ, Dunn IF, Chiocca EA, Trippa L, Santagata S, Folkerth RD, Kantoff P, Rollins BJ, Lindeman NI, Wen PY, Ligon AH, Beroukhim R, Alexander BM, Ligon KL. Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro Oncol. 2015 Oct; 17(10):1344-55. PMID: 25754088; PMCID: PMC4578577 [Available on 10/01/16].
  22. Shankar GM, Taylor-Weiner A, Lelic N, Jones RT, Kim JC, Francis JM, Abedalthagafi M, Borges LF, Coumans JV, Curry WT, Nahed BV, Shin JH, Paek SH, Park SH, Stewart C, Lawrence MS, Cibulskis K, Thorner AR, Van Hummelen P, Stemmer-Rachamimov AO, Batchelor TT, Carter SL, Hoang MP, Santagata S, Louis DN, Barker FG, Meyerson M, Getz G, Brastianos PK, Cahill DP. Sporadic hemangioblastomas are characterized by cryptic VHL inactivation. Acta Neuropathol Commun. 2014 Dec 24; 2:167. PMID: 25589003; PMCID: PMC4297409.
  23. Jones RT, Abedalthagafi MS, Brahmandam M, Greenfield EA, Hoang MP, Louis DN, Hornick JL, Santagata S. Cross-reactivity of the BRAF VE1 antibody with epitopes in axonemal dyneins leads to staining of cilia. Mod Pathol. 2015 Apr; 28(4):596-606. PMID: 25412847.
    View in: PubMed
  24. Abedalthagafi MS, Merrill PH, Bi WL, Jones RT, Listewnik ML, Ramkissoon SH, Thorner AR, Dunn IF, Beroukhim R, Alexander BM, Brastianos PK, Francis JM, Folkerth RD, Ligon KL, Van Hummelen P, Ligon AH, Santagata S. Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5. Oncotarget. 2014 Nov 15; 5(21):10596-606. PMID: 25347344; PMCID: PMC4279396.
  25. Cryan JB, Haidar S, Ramkissoon LA, Bi WL, Knoff DS, Schultz N, Abedalthagafi M, Brown L, Wen PY, Reardon DA, Dunn IF, Folkerth RD, Santagata S, Lindeman NI, Ligon AH, Beroukhim R, Hornick JL, Alexander BM, Ligon KL, Ramkissoon SH. Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas. Oncotarget. 2014 Sep 30; 5(18):8083-92. PMID: 25257301; PMCID: PMC4226668.
  26. Malik AN, Bi WL, McCray B, Abedalthagafi M, Vaitkevicius H, Dunn IF. Isolated cerebral mucormycosis of the basal ganglia. Clin Neurol Neurosurg. 2014 Sep; 124:102-5. PMID: 25019460; PMCID: PMC4256958.
  27. Aizer AA, Arvold ND, Catalano P, Claus EB, Golby AJ, Johnson MD, Al-Mefty O, Wen PY, Reardon DA, Lee EQ, Nayak L, Rinne ML, Beroukhim R, Weiss SE, Ramkissoon SH, Abedalthagafi M, Santagata S, Dunn IF, Alexander BM. Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma. Neuro Oncol. 2014 Nov; 16(11):1547-53. PMID: 24891451; PMCID: PMC4201070.
  28. Malak Abedalthagafi,1,2 Oren Rosenberg3 and Steve Miller1. First report of tenosynovitis in an immunocompetent person caused by Mycobacterium heraklionense. JMM Case Reports (2014) DOI 10.1099/jmmcr.0.002071 G 2014. 2014.
  29. Zhu J, Qiu J, Magrane G, Abedalthagafi M, Zanko A, Golabi M, Chehab FF. Correction: Duplication of C7orf58, WNT16 and FAM3C in an Obese Female with a t(7;22)(q32.1;q11.2) Chromosomal Translocation and Clinical Features Resembling Coffin-Siris Syndrome. PLoS One. 2013; 8(9). PMID: 24039678.
    View in: PubMed
  30. Abedalthagafi M, Phillips JJ, Kim GE, Mueller S, Haas-Kogen DA, Marshall RE, Croul SE, Santi MR, Cheng J, Zhou S, Sullivan LM, Martinez-Lage M, Judkins AR, Perry A. The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas. Mod Pathol. 2013 Nov; 26(11):1425-32. PMID: 23765250.
    View in: PubMed
  31. Zhu J, Qiu J, Magrane G, Abedalthagafi M, Zanko A, Golabi M, Chehab FF. Duplication of C7orf58, WNT16 and FAM3C in an obese female with a t(7;22)(q32.1;q11.2) chromosomal translocation and clinical features resembling Coffin-Siris Syndrome. PLoS One. 2012; 7(12):e52353. PMID: 23300646; PMCID: PMC3531478.
  32. Abedalthagafi M, Bakhshwin A. Radiation-induced glioma following CyberKnife® treatment of metastatic renal cell carcinoma: a case report. J Med Case Rep. 2012 Sep 03; 6:271. PMID: 22943305; PMCID: PMC3469351.
  33. Abedalthagafi M. Gastrointestinal stromal tumour originating from the hepatic falciform ligament. BMJ Case Rep. 2012 Jul 10; 2012. PMID: 22783003; PMCID: PMC4543157.
  34. Vahdat S, Oermann EK, Collins SP, Yu X, Abedalthagafi M, Debrito P, Suy S, Yousefi S, Gutierrez CJ, Chang T, Banovac F, Anderson ED, Esposito G, Collins BT. CyberKnife radiosurgery for inoperable stage IA non-small cell lung cancer: 18F-fluorodeoxyglucose positron emission tomography/computed tomography serial tumor response assessment. J Hematol Oncol. 2010 Feb 04; 3:6. PMID: 20132557; PMCID: PMC2830958.
  35. Abedalthagafi M, Rushing EJ, Auerbach A, Desouki MM, Marwaha J, Wang Z, Fanburg-Smith JC. Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1alpha: a histologic and immunohistochemical study of 45 cases. Ann Diagn Pathol. 2010 Feb; 14(1):15-22. PMID: 20123452.
    View in: PubMed
  36. Kelly T, Alvis C, Abedalthagafi M, Barnes W. Diagnostic evaluation of metastatic placental site trophoblastic tumor. Obstet Gynecol. 2009 Aug; 114(2 Pt 2):465-8. PMID: 19622963.
    View in: PubMed
  37. Abedalthagafi M, Guo H, Hartmann DP, Ozdemirli M. Absence of FLT3 and JAK2 (V617F) mutations in Langerhans cell histiocytosis. Leuk Res. 2009 Sep; 33(9):e173-4. PMID: 19395028.
    View in: PubMed
  38. Abedalthagafi M, Rushing EJ, Garvin D, Cheson B, Ozdemirli M. Asymptomatic diffuse "encephalitic" cerebral toxoplasmosis in a patient with chronic lymphocytic leukemia: case report and review of the literature. Int J Clin Exp Pathol. 2009 Mar 15; 3(1):106-9. PMID: 19918334; PMCID: PMC2776259.
  39. Abedalthagafi M, Jackson PG, Ozdemirli M. Primary retroperitoneal mucinous cystadenoma. Saudi Med J. 2009 Jan; 30(1):146-9. PMID: 19139790.
    View in: PubMed
  40. Sandler SG, Abedalthagafi MM. Historic milestones in the evolution of the crossmatch. Immunohematology. 2009; 25(4):147-51. PMID: 20406021.
    View in: PubMed
  41. Sandler SG, Abedalthagafi M, Langeberg A. Is a computer crossmatch in the absence of an immediate-spin antibody screen adequate for persons identified to be at increased risk of forming new blood group antibodies? Transfusion. 2008 Oct; 48(10):2265-6. PMID: 18928510.
    View in: PubMed
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