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Rod Amir Rahimi, M.D.,Ph.D.

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Biography
Mayo Clinic 2010MD-PhD program
Johns Hopkins Hospital2013Internal Medicine Residency
Massachusetts General Hospital2017Pulmonary and Critical Care Medicine Fellowship

Overview
The structure and function of the mammalian lung exposes the host to a myriad of inhaled particulate matter, allergens, and pathogens. The immune system plays an essential role in protecting the host from respiratory pathogens, but inappropriate immunity to harmless inhaled antigens can lead to pulmonary diseases. CD4+ T helper cells play a critical role in antigen-specific immune responses and can persist as long-lived, memory T cells that maintain antigen-specific immunity. The central focus of our laboratory is defining the mechanisms regulating CD4+ T cell responses to inhaled antigens in the context of health and disease. We are particularly interested in understanding how CD4+ T cells inappropriately respond to harmless allergens and develop into allergen-specific, memory CD4+ T cells driving chronic allergic airway disease. We utilize both murine models and human subjects to define CD4+ T cell fate decisions in response to allergens. Our goal is to define novel therapeutic targets to prevent or treat allergic diseases such as asthma.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08HL140173 (RAHIMI, ROD AMIR) Dec 8, 2017 - Dec 6, 2022
    NIH
    The Role of Lung-Resident Memory Th2 cells in Asthma
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Faustino LD, Griffith JW, Rahimi RA, Nepal K, Hamilos DL, Cho JL, Medoff BD, Moon JJ, Vignali DAA, Luster AD. Interleukin-33 activates regulatory T cells to suppress innate gd T cell responses in the lung. Nat Immunol. 2020.
  2. Rahimi RA, Nepal K, Cetinbas M, Sadreyev RI, Luster AD. Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease. J Exp Med. 2020.
  3. Rahimi RA, Luster AD. Redefining Memory T Cell Subsets. Trends Immunol. 2020 08; 41(8):645-648. PMID: 32646595.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Mani V, Bromley SK, Äijö T, Mora-Buch R, Carrizosa E, Warner RD, Hamze M, Sen DR, Chasse AY, Lorant A, Griffith JW, Rahimi RA, McEntee CP, Jeffrey KL, Marangoni F, Travis MA, Lacy-Hulbert A, Luster AD, Mempel TR. Migratory DCs activate TGF-ß to precondition naïve CD8+ T cells for tissue-resident memory fate. Science. 2019 10 11; 366(6462). PMID: 31601741.
    Citations: 23     Fields:    Translation:AnimalsCells
  5. Miyabe C, Miyabe Y, Bricio-Moreno L, Lian J, Rahimi RA, Miura NN, Ohno N, Iwakura Y, Kawakami T, Luster AD. Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis. J Clin Invest. 2019 06 06; 129(9):3610-3624. PMID: 31169521.
    Citations: 3     Fields:    Translation:AnimalsCells
  6. Rahimi RA, Luster AD. Chemokines: Critical Regulators of Memory T Cell Development, Maintenance, and Function. Adv Immunol. 2018; 138:71-98. PMID: 29731007.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Lagares D, Santos A, Grasberger PE, Liu F, Probst CK, Rahimi RA, Sakai N, Kuehl T, Ryan J, Bhola P, Montero J, Kapoor M, Baron M, Varelas X, Tschumperlin DJ, Letai A, Tager AM. Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis. Sci Transl Med. 2017 Dec 13; 9(420). PMID: 29237758.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  8. Andrianifahanana M, Wilkes MC, Gupta SK, Rahimi RA, Repellin CE, Edens M, Wittenberger J, Yin X, Maidl E, Becker J, Leof EB. Profibrotic TGFß responses require the cooperative action of PDGF and ErbB receptor tyrosine kinases. FASEB J. 2013 Nov; 27(11):4444-54. PMID: 23913859.
    Citations: 20     Fields:    Translation:AnimalsCells
  9. Rahimi RA, Skrzat J, Reddy DR, Zanni JM, Fan E, Stephens RS, Needham DM. Physical rehabilitation of patients in the intensive care unit requiring extracorporeal membrane oxygenation: a small case series. Phys Ther. 2013 Feb; 93(2):248-55. PMID: 23104895.
    Citations: 10     Fields:    Translation:Humans
  10. Andrianifahanana M, Wilkes MC, Repellin CE, Edens M, Kottom TJ, Rahimi RA, Leof EB. ERBB receptor activation is required for profibrotic responses to transforming growth factor beta. Cancer Res. 2010 Oct 01; 70(19):7421-30. PMID: 20841477.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  11. Rahimi RA, Leof EB. TGFbeta versatility: PI3K as a critical mediator of distinct cell type and context specific responses. Cell Cycle. 2009; 8(12):1813-4.
  12. Rahimi RA, Andrianifahanana M, Wilkes MC, Edens M, Kottom TJ, Blenis J, Leof EB. Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-beta. Cancer Res. 2009 Jan 01; 69(1):84-93. PMID: 19117990.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  13. Rahimi RA, Allmond JJ, Wagner H, McCauley DW, Langeland JA. Lamprey snail highlights conserved and novel patterning roles in vertebrate embryos. Dev Genes Evol. 2009 Jan; 219(1):31-6. PMID: 18949485.
    Citations: 4     Fields:    Translation:Animals
  14. Rahimi RA, Leof EB. TGF-beta signaling: a tale of two responses. J Cell Biochem. 2007 Oct 15; 102(3):593-608. PMID: 17729308.
    Citations: 163     Fields:    Translation:HumansAnimalsCells
  15. Wilke RA, Kolbert CP, Rahimi RA, Windebank AJ. Methylmercury induces apoptosis in cultured rat dorsal root ganglion neurons. Neurotoxicology. 2003 Jun; 24(3):369-78. PMID: 12782102.
    Citations: 8     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.