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Alexander Bartelt

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lemmer IL, Willemsen N, Hilal N, Bartelt A. A guide to understanding endoplasmic reticulum stress in metabolic disorders. Mol Metab. 2021 Jan 20; 47:101169. PMID: 33484951.
    Citations:    Fields:    
  2. Schlein C, Fischer AW, Sass F, Worthmann A, Tödter K, Jaeckstein MY, Behrens J, Lynes MD, Kiebish MA, Narain NR, Bussberg V, Darkwah A, Jespersen NZ, Nielsen S, Scheele C, Schweizer M, Braren I, Bartelt A, Tseng YH, Heeren J, Scheja L. Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution. Cell Rep. 2021 Jan 12; 34(2):108624. PMID: 33440156.
    Citations:    Fields:    
  3. Goncalves RLS, Schlame M, Bartelt A, Brand MD, Hotamisligil GS. Cardiolipin deficiency in Barth syndrome is not associated with increased superoxide/H2 O2 production in heart and skeletal muscle mitochondria. FEBS Lett. 2021 Feb; 595(3):415-432. PMID: 33112430.
    Citations: 1     Fields:    
  4. Bartelt A, Weber C. Mitochondrial Ejection for Cardiac Protection: The Macrophage Connection. Cell Metab. 2020 Oct 06; 32(4):512-513. PMID: 33027673.
    Citations:    Fields:    
  5. Bartelt A, Widenmaier SB. Proteostasis in thermogenesis and obesity. Biol Chem. 2020 08 27; 401(9):1019-1030. PMID: 32061163.
    Citations: 1     Fields:    
  6. Bartelt A, Leipsic J, Weber C. The new age of radiomic risk profiling: perivascular fat at the heart of the matter. Eur Heart J. 2019 11 14; 40(43):3544-3546. PMID: 31605139.
    Citations: 1     Fields:    
  7. Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Blüher M, Cypess AM, Kiebish MA, Spite M, Tseng YH. 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Cell Metab. 2019 10 01; 30(4):768-783.e7. PMID: 31353262.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  8. Worthmann A, Schlein C, Berbée JFP, Rensen PCN, Heeren J, Bartelt A. Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression. Nutrients. 2019 Feb 23; 11(2). PMID: 30813320.
    Citations: 2     Fields:    Translation:AnimalsCells
  9. Treviño-Villarreal JH, Reynolds JS, Bartelt A, Langston PK, MacArthur MR, Arduini A, Tosti V, Veronese N, Bertozzi B, Brace LE, Mejia P, Trocha K, Kajitani GS, Longchamp A, Harputlugil E, Gathungu R, Bird SS, Bullock AD, Figenshau RS, Andriole GL, Thompson A, Heeren J, Ozaki CK, Kristal BS, Fontana L, Mitchell JR. Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms. JCI Insight. 2018 11 02; 3(21). PMID: 30385734.
    Citations: 4     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  10. Bartelt A, Behler-Janbeck F, Beil FT, Koehne T, Müller B, Schmidt T, Heine M, Ochs L, Yilmaz T, Dietrich M, Tuckermann JP, Amling M, Herz J, Schinke T, Heeren J, Niemeier A. Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling. Bone Res. 2018; 6:4. PMID: 29507818.
    Citations: 6     
  11. Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS. Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nat Med. 2018 03; 24(3):292-303. PMID: 29400713.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  12. Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GS. NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis. Cell. 2017 Nov 16; 171(5):1094-1109.e15. PMID: 29149604.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  13. Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH. Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017 Nov 07; 23(11):1384. PMID: 29117173.
    Citations: 2     Fields:    
  14. Hoeke G, Nahon K, Bartelt A, Dinnes D, Drettwan D, Pagel P, Jazet I, Kockx M, Kritharides L, Heeren J, Berbeé J, Boon M, Rensen P. Cold exposure beneficially modulates HDL metabolism in mice and humans. Atherosclerosis. 2017 Aug; 263:e95. PMID: 29366282.
    Citations:    Fields:    
  15. Bartelt A, Jeschke A, Müller B, Gaziano I, Morales M, Yorgan T, Heckt T, Heine M, Gagel RF, Emeson RB, Amling M, Niemeier A, Heeren J, Schinke T, Keller J. Differential effects of Calca-derived peptides in male mice with diet-induced obesity. PLoS One. 2017; 12(6):e0180547. PMID: 28666011.
    Citations: 1     Fields:    Translation:Animals
  16. Bartelt A, Koehne T, Tödter K, Reimer R, Müller B, Behler-Janbeck F, Heeren J, Scheja L, Niemeier A. Quantification of Bone Fatty Acid Metabolism and Its Regulation by Adipocyte Lipoprotein Lipase. Int J Mol Sci. 2017 Jun 13; 18(6). PMID: 28608812.
    Citations: 11     Fields:    Translation:AnimalsCells
  17. Bartelt A, John C, Schaltenberg N, Berbée JFP, Worthmann A, Cherradi ML, Schlein C, Piepenburg J, Boon MR, Rinninger F, Heine M, Toedter K, Niemeier A, Nilsson SK, Fischer M, Wijers SL, van Marken Lichtenbelt W, Scheja L, Rensen PCN, Heeren J. Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport. Nat Commun. 2017 04 19; 8:15010. PMID: 28422089.
    Citations: 26     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  18. Bruns OT, Bischof TS, Harris DK, Franke D, Shi Y, Riedemann L, Bartelt A, Jaworski FB, Carr JA, Rowlands CJ, Wilson MWB, Chen O, Wei H, Hwang GW, Montana DM, Coropceanu I, Achorn OB, Kloepper J, Heeren J, So PTC, Fukumura D, Jensen KF, Jain RK, Bawendi MG. Next-generation in vivo optical imaging with short-wave infrared quantum dots. Nat Biomed Eng. 2017; 1. PMID: 29119058.
    Citations: 58     Fields:    
  19. Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017 May; 23(5):631-637. PMID: 28346411.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  20. Wagner T, Bartelt A, Schlein C, Heeren J. Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity. PLoS One. 2015; 10(12):e0145102. PMID: 26695075.
    Citations: 4     Fields:    Translation:AnimalsCells
  21. Longchamp A, Tao M, Bartelt A, Ding K, Lynch L, Hine C, Corpataux JM, Kristal BS, Mitchell JR, Ozaki CK. Surgical injury induces local and distant adipose tissue browning. Adipocyte. 2016 Apr-Jun; 5(2):163-74. PMID: 27386152.
    Citations: 4     Fields:    
  22. Lasrich D, Bartelt A, Grewal T, Heeren J. Apolipoprotein E promotes lipid accumulation and differentiation in human adipocytes. Exp Cell Res. 2015 Sep 10; 337(1):94-102. PMID: 26201081.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  23. Berbée JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun. 2015 Mar 10; 6:6356. PMID: 25754609.
    Citations: 105     Fields:    Translation:Animals
  24. Heine M, Bartelt A, Bruns OT, Bargheer D, Giemsa A, Freund B, Scheja L, Waurisch C, Eychmüller A, Reimer R, Weller H, Nielsen P, Heeren J. The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver. Beilstein J Nanotechnol. 2014; 5:1432-1440. PMID: 25247125.
    Citations: 4     
  25. Bartelt A, Beil FT, Müller B, Koehne T, Yorgan TA, Heine M, Yilmaz T, Rüther W, Heeren J, Schinke T, Niemeier A. Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity. Bone. 2014 May; 62:90-8. PMID: 24440515.
    Citations: 3     Fields:    Translation:AnimalsCells
  26. Albers K, Schlein C, Wenner K, Lohse P, Bartelt A, Heeren J, Santer R, Merkel M. Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant. Atherosclerosis. 2014 Mar; 233(1):97-103. PMID: 24529129.
    Citations: 5     Fields:    Translation:HumansCells
  27. Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nat Rev Endocrinol. 2014 Jan; 10(1):24-36. PMID: 24146030.
    Citations: 274     Fields:    Translation:HumansAnimalsCells
  28. Dieckmann M, Beil FT, Mueller B, Bartelt A, Marshall RP, Koehne T, Amling M, Ruether W, Cooper JA, Humphries SE, Herz J, Niemeier A. Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo. J Bone Miner Res. 2013 Feb; 28(2):236-45. PMID: 22991192.
    Citations: 7     Fields:    Translation:HumansAnimals
  29. Eissing L, Scherer T, Tödter K, Knippschild U, Greve JW, Buurman WA, Pinnschmidt HO, Rensen SS, Wolf AM, Bartelt A, Heeren J, Buettner C, Scheja L. De novo lipogenesis in human fat and liver is linked to ChREBP-ß and metabolic health. Nat Commun. 2013; 4:1528. PMID: 23443556.
    Citations: 90     Fields:    Translation:HumansCells
  30. Bartelt A, Weigelt C, Cherradi ML, Niemeier A, Tödter K, Heeren J, Scheja L. Effects of adipocyte lipoprotein lipase on de novo lipogenesis and white adipose tissue browning. Biochim Biophys Acta. 2013 May; 1831(5):934-42. PMID: 23228690.
    Citations: 18     Fields:    Translation:AnimalsCells
  31. Freund B, Tromsdorf UI, Bruns OT, Heine M, Giemsa A, Bartelt A, Salmen SC, Raabe N, Heeren J, Ittrich H, Reimer R, Hohenberg H, Schumacher U, Weller H, Nielsen P. A simple and widely applicable method to 59Fe-radiolabel monodisperse superparamagnetic iron oxide nanoparticles for in vivo quantification studies. ACS Nano. 2012 Aug 28; 6(8):7318-25. PMID: 22793497.
    Citations: 20     Fields:    Translation:Animals
  32. Gordts PL, Bartelt A, Nilsson SK, Annaert W, Christoffersen C, Nielsen LB, Heeren J, Roebroek AJ. Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice. PLoS One. 2012; 7(6):e38330. PMID: 22701627.
    Citations: 15     Fields:    Translation:AnimalsCells
  33. Bartelt A, Heeren J. The holy grail of metabolic disease: brown adipose tissue. Curr Opin Lipidol. 2012 Jun; 23(3):190-5. PMID: 22449813.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  34. Bartelt A, Merkel M, Heeren J. A new, powerful player in lipoprotein metabolism: brown adipose tissue. J Mol Med (Berl). 2012 Aug; 90(8):887-93. PMID: 22231746.
    Citations: 24     Fields:    Translation:HumansAnimals
  35. Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Weller H, Waurisch C, Eychmüller A, Gordts PL, Rinninger F, Bruegelmann K, Freund B, Nielsen P, Merkel M, Heeren J. Brown adipose tissue activity controls triglyceride clearance. Nat Med. 2011 Feb; 17(2):200-5. PMID: 21258337.
    Citations: 541     Fields:    Translation:HumansAnimals
  36. Cuchet D, Sykes A, Nicolas A, Orr A, Murray J, Sirma H, Heeren J, Bartelt A, Everett RD. PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication. J Cell Sci. 2011 Jan 15; 124(Pt 2):280-91. PMID: 21172801.
    Citations: 54     Fields:    Translation:HumansCells
  37. Prawitt J, Beil FT, Marshall RP, Bartelt A, Ruether W, Heeren J, Amling M, Staels B, Niemeier A. Short-term activation of liver X receptors inhibits osteoblasts but long-term activation does not have an impact on murine bone in vivo. Bone. 2011 Feb; 48(2):339-46. PMID: 20817130.
    Citations: 8     Fields:    Translation:AnimalsCells
  38. Bartelt A, Beil FT, Schinke T, Roeser K, Ruether W, Heeren J, Niemeier A. Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: modulation by diet-induced obesity. Bone. 2010 Oct; 47(4):736-45. PMID: 20633710.
    Citations: 20     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.