Harvard Catalyst Profiles

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Christopher A Alvarez-Breckenridge, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Brastianos PK, Lee EQ, Cohen JV, Tolaney SM, Lin NU, Wang N, Chukwueke U, White MD, Nayyar N, Kim A, Alvarez-Breckenridge C, Krop I, Mahar MK, Bertalan MS, Shaw B, Mora JL, Goss N, Subramanian M, Nayak L, Dietrich J, Forst DA, Nahed BV, Batchelor TT, Shih HA, Gerstner ER, Moy B, Lawrence D, Giobbie-Hurder A, Carter SL, Oh K, Cahill DP, Sullivan RJ. Publisher Correction: Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis. Nat Med. 2020 Jun 18. PMID: 32555425.
  2. Massaad E, Hadzipasic M, Alvarez-Breckenridge C, Kiapour A, Fatima N, Schwab JH, Saylor P, Oh K, Schoenfeld AJ, Shankar GM, Shin JH. Predicting tumor-specific survival in patients with spinal metastatic renal cell carcinoma: which scoring system is most accurate? J Neurosurg Spine. 2020 Jun 05; 1-11. PMID: 32502990.
  3. Brastianos PK, Lee EQ, Cohen JV, Tolaney SM, Lin NU, Wang N, Chukwueke U, White MD, Nayyar N, Kim A, Alvarez-Breckenridge C, Krop I, Mahar MK, Bertalan MS, Shaw B, Mora JL, Goss N, Subramanian M, Nayak L, Dietrich J, Forst DA, Nahed BV, Batchelor TT, Shih HA, Gerstner ER, Moy B, Lawrence D, Giobbie-Hurder A, Carter SL, Oh K, Cahill DP, Sullivan RJ. Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis. Nat Med. 2020 Jun 02. PMID: 32483359.
  4. Fatima N, Massaad E, Alvarez-Breckenridge C, Berry Candelario JE, Hadzipasic M, Shankar GM, Shin JH. Does Obesity Correlate with Postoperative Morbidity Following Elective Posterior Cervical Fusion Surgery? World Neurosurg. 2020 May 17. PMID: 32434032.
  5. Shih DJH, Nayyar N, Bihun I, Dagogo-Jack I, Gill CM, Aquilanti E, Bertalan M, Kaplan A, D'Andrea MR, Chukwueke U, Ippen FM, Alvarez-Breckenridge C, Camarda ND, Lastrapes M, McCabe D, Kuter B, Kaufman B, Strickland MR, Martinez-Gutierrez JC, Nagabhushan D, De Sauvage M, White MD, Castro BA, Hoang K, Kaneb A, Batchelor ED, Paek SH, Park SH, Martinez-Lage M, Berghoff AS, Merrill P, Gerstner ER, Batchelor TT, Frosch MP, Frazier RP, Borger DR, Iafrate AJ, Johnson BE, Santagata S, Preusser M, Cahill DP, Carter SL, Brastianos PK. Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma. Nat Genet. 2020 04; 52(4):371-377. PMID: 32203465.
  6. Massaad E, Fatima N, Hadzipasic M, Alvarez-Breckenridge C, Shankar GM, Shin JH. Predictive Analytics in Spine Oncology Research: First Steps, Limitations, and Future Directions. Neurospine. 2019 Dec; 16(4):669-677. PMID: 31905455.
  7. Alvarez-Breckenridge C, Nahed BV. In Reply: Congress of Neurological Surgeons Systematic Review and Evidence-Based Practice Guidelines on the Role of Surgery in the Management of Adults With Metastatic Brain Tumors. Neurosurgery. 2019 09 01; 85(3):E618. PMID: 31418034.
  8. Nahed BV, Alvarez-Breckenridge C, Brastianos PK, Shih H, Sloan A, Ammirati M, Kuo JS, Ryken TC, Kalkanis SN, Olson JJ. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Surgery in the Management of Adults With Metastatic Brain Tumors. Neurosurgery. 2019 03 01; 84(3):E152-E155. PMID: 30629227.
    Citations:    Fields:    
  9. Alvarez-Breckenridge C, Giobbie-Hurder A, Gill CM, Bertalan M, Stocking J, Kaplan A, Nayyar N, Lawrence DP, Flaherty KT, Shih HA, Oh K, Batchelor TT, Cahill DP, Sullivan R, Brastianos PK. Upfront Surgical Resection of Melanoma Brain Metastases Provides a Bridge Toward Immunotherapy-Mediated Systemic Control. Oncologist. 2019 05; 24(5):671-679. PMID: 30796152.
  10. Ippen FM, Alvarez-Breckenridge CA, Kuter BM, Fink AL, Bihun IV, Lastrapes M, Penson T, Schmidt SP, Wojtkiewicz GR, Ning J, Subramanian M, Giobbie-Hurder A, Martinez-Lage M, Carter SL, Cahill DP, Wakimoto H, Brastianos PK. The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases. Clin Cancer Res. 2019 06 01; 25(11):3374-3383. PMID: 30796030.
  11. Alvarez-Breckenridge C, Miller JJ, Nayyar N, Gill CM, Kaneb A, D'Andrea M, Le LP, Lee J, Cheng J, Zheng Z, Butler WE, Multani P, Chow Maneval E, Ha Paek S, Toyota BD, Dias-Santagata D, Santagata S, Romero J, Shaw AT, Farago AF, Yip S, Cahill DP, Batchelor TT, Iafrate AJ, Brastianos PK. Clinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor. NPJ Precis Oncol. 2017; 1(1):5. PMID: 29872694.
    Citations: 2     
  12. Alvarez-Breckenridge C, Brastianos PK. SMO mutant olfactory groove meningiomas-the next in line for targeted therapy. Neuro Oncol. 2017 03 01; 19(3):305-306. PMID: 28391317.
    Citations:    Fields:    
  13. Bolyard C, Meisen WH, Banasavadi-Siddegowda Y, Hardcastle J, Yoo JY, Wohleb ES, Wojton J, Yu JG, Dubin S, Khosla M, Xu B, Smith J, Alvarez-Breckenridge C, Pow-Anpongkul P, Pichiorri F, Zhang J, Old M, Zhu D, Van Meir EG, Godbout JP, Caligiuri MA, Yu J, Kaur B. BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection-Implications for Oncolytic Viral Therapy. Clin Cancer Res. 2017 Apr 01; 23(7):1809-1819. PMID: 27852701.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  14. Alvarez-Breckenridge CA, Attiah MA, Zachariah M, Gummadavelli A, Yang J, Codd PJ. Ventriculoperitoneal shunt placement for POEMS syndrome. J Clin Neurosci. 2015 Oct; 22(10):1672-4. PMID: 26077937.
    Citations:    Fields:    Translation:Humans
  15. Suryadevara CM, Gedeon PC, Sanchez-Perez L, Verla T, Alvarez-Breckenridge C, Choi BD, Fecci PE, Sampson JH. Are BiTEs the "missing link" in cancer therapy? Oncoimmunology. 2015 Jun; 4(6):e1008339. PMID: 26155413.
    Citations: 16     
  16. Alvarez-Breckenridge CA, Choi BD, Suryadevara CM, Chiocca EA. Potentiating oncolytic viral therapy through an understanding of the initial immune responses to oncolytic viral infection. Curr Opin Virol. 2015 Aug; 13:25-32. PMID: 25846988.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  17. Han J, Alvarez-Breckenridge CA, Wang QE, Yu J. TGF-ß signaling and its targeting for glioma treatment. Am J Cancer Res. 2015; 5(3):945-55. PMID: 26045979.
    Citations: 31     
  18. Kaur B, Meisen WH, Hardcastle J, Wojton J, Wohleb E, Alvarez-Breckenridge C, Pow-Anpongkul P, Godbout J, Kaur B. Vstat120 reduces the innate inflammatory response to infection and enhances oncolytic viral therapy for glioblastoma. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii42. PMID: 25165328.
  19. Price RL, Song J, Bingmer K, Kim TH, Yi JY, Nowicki MO, Mo X, Hollon T, Murnan E, Alvarez-Breckenridge C, Fernandez S, Kaur B, Rivera A, Oglesbee M, Cook C, Chiocca EA, Kwon CH. Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Cancer Res. 2013 Jun 01; 73(11):3441-50. PMID: 23729642.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  20. He S, Chu J, Wu LC, Mao H, Peng Y, Alvarez-Breckenridge CA, Hughes T, Wei M, Zhang J, Yuan S, Sandhu S, Vasu S, Benson DM, Hofmeister CC, He X, Ghoshal K, Devine SM, Caligiuri MA, Yu J. MicroRNAs activate natural killer cells through Toll-like receptor signaling. Blood. 2013 Jun 06; 121(23):4663-71. PMID: 23580661.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  21. Alvarez-Breckenridge CA, Yu J, Caligiuri MA, Chiocca EA. Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy. Oncoimmunology. 2013 Apr 01; 2(4):e23658. PMID: 23734319.
    Citations: 4     
  22. Alvarez-Breckenridge CA, Yu J, Price R, Wojton J, Pradarelli J, Mao H, Wei M, Wang Y, He S, Hardcastle J, Fernandez SA, Kaur B, Lawler SE, Vivier E, Mandelboim O, Moretta A, Caligiuri MA, Chiocca EA. NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nat Med. 2012 Dec; 18(12):1827-34. PMID: 23178246.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  23. Yoo JY, Pradarelli J, Haseley A, Wojton J, Kaka A, Bratasz A, Alvarez-Breckenridge CA, Yu JG, Powell K, Mazar AP, Teknos TN, Chiocca EA, Glorioso JC, Old M, Kaur B. Copper chelation enhances antitumor efficacy and systemic delivery of oncolytic HSV. Clin Cancer Res. 2012 Sep 15; 18(18):4931-41. PMID: 22753591.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  24. Alvarez-Breckenridge CA, Yu J, Price R, Wei M, Wang Y, Nowicki MO, Ha YP, Bergin S, Hwang C, Fernandez SA, Kaur B, Caligiuri MA, Chiocca EA. The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon. J Virol. 2012 Apr; 86(8):4566-77. PMID: 22318143.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  25. Alvarez-Breckenridge CA, Yu J, Kaur B, Caligiuri MA, Chiocca EA. Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells. Adv Virol. 2012; 2012:702839. PMID: 22312364.
    Citations: 9     
  26. Alvarez-Breckenridge C, Chiocca EA. A viral strategy to ambush tumors. Nat Med. 2011 Jul 07; 17(7):784-5. PMID: 21738155.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  27. Yu J, Mitsui T, Wei M, Mao H, Butchar JP, Shah MV, Zhang J, Mishra A, Alvarez-Breckenridge C, Liu X, Liu S, Yokohama A, Trotta R, Marcucci G, Benson DM, Loughran TP, Tridandapani S, Caligiuri MA. NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human. J Clin Invest. 2011 Apr; 121(4):1456-70. PMID: 21364281.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  28. Alvarez-Breckenridge C, Kaur B, Chiocca EA. Pharmacologic and chemical adjuvants in tumor virotherapy. Chem Rev. 2009 Jul; 109(7):3125-40. PMID: 19462957.
    Citations: 21     Fields:    Translation:HumansCells
  29. Haseley A, Alvarez-Breckenridge C, Chaudhury AR, Kaur B. Advances in oncolytic virus therapy for glioma. Recent Pat CNS Drug Discov. 2009 Jan; 4(1):1-13. PMID: 19149710.
    Citations: 15     Fields:    Translation:HumansAnimals
  30. Alvarez-Breckenridge CA, Waite KA, Eng C. PTEN regulates phospholipase D and phospholipase C. Hum Mol Genet. 2007 May 15; 16(10):1157-63. PMID: 17405772.
    Citations: 4     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.