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Christian Lacks Lino Cardenas, Ph.D., Pharm.D.

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Biography
HMS/MGH, Boston-USAResearch fellow10/2017Cardiovascular/Epigenomics
UPMC, Pittsburgh-USAResearch fellow06/2013Pulmonology/RNA biology
CHRU Lille, Lille-FranceResearch fellow10/2011Pulmonology/miRNAs
CHRU Lille, Lille-FrancePhD11/2010Genetics/Molecular biology
University of Lille, Lille-FranceMSc06/2007Microbiology/Genetics
University Catholic of Saint Mary, Arequipa-PeruPharmD04/2005Pharmacology/Biochemistry

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. (Sakhuja, Rahul) Nov 20, 2020 - May 13, 2022
    Bristol Myers Squibb
    A Randomized, Open-Label Trial of Therapeutic Anticoagulation in COVID-19 Patients with an Elevated D-Dimer
    Role: Co-Investigador
  2. 5T32HL007208-43 (ROSENZWEIG, ANTHONY) Jul 20, 2020 - Jun 30, 2021
    National Institutes of Health (NIH)
    Therapeutic activation of autophagy inhibits calcification of small and large arteries.
    Role: trainee
  3. Physician-Scientist Development Award (PSDA) (Christian L. Lino Cardenas) Jul 1, 2020 - Jun 20, 2024
    Executive Committee on Research (ECOR)
    HDAC9 is a novel negative regulator of autophagy pathway in Thoracic Aortic Aneurysm
    Role: PI
  4. Pilot Translational Research Grant (Rajeev Malhotra) Mar 1, 2019 - Mar 31, 2021
    MGH Department of Medicine
    Autophagy as a Novel Determinant of Calciphylaxis
    Role: Co-PI

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Oller J, Gabandé-Rodríguez E, Ruiz-Rodríguez MJ, Desdín-Micó G, Aranda JF, Rodrigues-Diez R, Ballesteros-Martínez C, Blanco EM, Roldan-Montero R, Acuña P, Forteza Gil A, Martín-López CE, Nistal JF, Lino Cardenas CL, Lindsay ME, Martín-Ventura JL, Briones AM, Miguel Redondo J, Mittelbrunn M. Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm. Circulation. 2021 May 25; 143(21):2091-2109. PMID: 33709773.
    Citations:    Fields:    
  2. Nicholson CJ, Wooster L, Sigurslid HH, Li RH, Jiang W, Tian W, Lino Cardenas CL, Malhotra R. Estimating risk of mechanical ventilation and in-hospital mortality among adult COVID-19 patients admitted to Mass General Brigham: The VICE and DICE scores. EClinicalMedicine. 2021 Mar; 33:100765. PMID: 33655204.
    Citations: 4     
  3. Chávez-Fumagalli MA, Shrivastava P, Aguilar-Pineda JA, Nieto-Montesinos R, Del-Carpio GD, Peralta-Mestas A, Caracela-Zeballos C, Valdez-Lazo G, Fernandez-Macedo V, Pino-Figueroa A, Vera-Lopez KJ, Lino Cardenas CL. Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy. J Alzheimers Dis Rep. 2021 Jan 11; 5(1):15-30. PMID: 33681713.
    Citations:    
  4. Aguilar-Pineda JA, Albaghdadi M, Jiang W, Lopez KJV, Del-Carpio GD, Valdez BG, Lindsay ME, Malhotra R, Lino Cardenas CL. Structural and functional analysis of female sex hormones against SARS-Cov2 cell entry. bioRxiv. 2020 Jul 29. PMID: 32766583.
    Citations:    
  5. Thayer TE, Lino Cardenas CL, Martyn T, Nicholson CJ, Traeger L, Wunderer F, Slocum C, Sigurslid H, Shakartzi HR, O'Rourke C, Shelton G, Buswell MD, Barnes H, Neitzel LR, Ledsky CD, Li JP, Burke MF, Farber-Eger E, Perrien DS, Kumar R, Corey KE, Wells QS, Bloch KD, Hong CC, Bloch DB, Malhotra R. The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease. Sci Rep. 2020 06 19; 10(1):9831. PMID: 32561790.
    Citations:    Fields:    Translation:AnimalsCells
  6. Chowdhury MM, Singh K, Albaghdadi MS, Khraishah H, Mauskapf A, Kessinger CW, Osborn EA, Kellnberger S, Piao Z, Lino Cardenas CL, Grau MS, Jaff MR, Rosenfield K, Libby P, Edelman ER, Lindsay ME, Tearney GJ, Jaffer FA. Paclitaxel Drug-Coated Balloon Angioplasty Suppresses Progression and Inflammation of Experimental Atherosclerosis in Rabbits. JACC Basic Transl Sci. 2020 Jul; 5(7):685-695. PMID: 32760856.
    Citations: 1     
  7. Malhotra R, Mauer AC, Lino Cardenas CL, Guo X, Yao J, Zhang X, Wunderer F, Smith AV, Wong Q, Pechlivanis S, Hwang SJ, Wang J, Lu L, Nicholson CJ, Shelton G, Buswell MD, Barnes HJ, Sigurslid HH, Slocum C, Rourke CO, Rhee DK, Bagchi A, Nigwekar SU, Buys ES, Campbell CY, Harris T, Budoff M, Criqui MH, Rotter JI, Johnson AD, Song C, Franceschini N, Debette S, Hoffmann U, Kälsch H, Nöthen MM, Sigurdsson S, Freedman BI, Bowden DW, Jöckel KH, Moebus S, Erbel R, Feitosa MF, Gudnason V, Thanassoulis G, Zapol WM, Lindsay ME, Bloch DB, Post WS, O'Donnell CJ. HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. Nat Genet. 2019 11; 51(11):1580-1587. PMID: 31659325.
    Citations: 7     Fields:    Translation:HumansAnimals
  8. Boileau A, Lino Cardenas CL, Courtois A, Zhang L, Rodosthenous RS, Das S, Sakalihasan N, Michel JB, Lindsay ME, Devaux Y. MiR-574-5p: A Circulating Marker of Thoracic Aortic Aneurysm. Int J Mol Sci. 2019 08 12; 20(16). PMID: 31409059.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  9. Savary G, Dewaeles E, Diazzi S, Buscot M, Nottet N, Fassy J, Courcot E, Henaoui IS, Lemaire J, Martis N, Van der Hauwaert C, Pons N, Magnone V, Leroy S, Hofman V, Plantier L, Lebrigand K, Paquet A, Lino Cardenas CL, Vassaux G, Hofman P, Günther A, Crestani B, Wallaert B, Rezzonico R, Brousseau T, Glowacki F, Bellusci S, Perrais M, Broly F, Barbry P, Marquette CH, Cauffiez C, Mari B, Pottier N. The Long Noncoding RNA DNM3OS Is a Reservoir of FibromiRs with Major Functions in Lung Fibroblast Response to TGF-ß and Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 07 15; 200(2):184-198. PMID: 30964696.
    Citations: 17     Fields:    Translation:AnimalsCells
  10. Lino Cardenas CL, Kessinger CW, Chou EL, Ghoshhajra B, Yeri AS, Das S, Weintraub NL, Malhotra R, Jaffer FA, Lindsay ME. HDAC9 complex inhibition improves smooth muscle-dependent stenotic vascular disease. JCI Insight. 2019 01 24; 4(2). PMID: 30674723.
    Citations: 3     Fields:    
  11. Gould RA, Aziz H, Woods CE, Seman-Senderos MA, Sparks E, Preuss C, Wünnemann F, Bedja D, Moats CR, McClymont SA, Rose R, Sobreira N, Ling H, MacCarrick G, Kumar AA, Luyckx I, Cannaerts E, Verstraeten A, Björk HM, Lehsau AC, Jaskula-Ranga V, Lauridsen H, Shah AA, Bennett CL, Ellinor PT, Lin H, Isselbacher EM, Lino Cardenas CL, Butcher JT, Hughes GC, Lindsay ME, Mertens L, Franco-Cereceda A, Verhagen JMA, Wessels M, Mohamed SA, Eriksson P, Mital S, Van Laer L, Loeys BL, Andelfinger G, McCallion AS, Dietz HC. ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm. Nat Genet. 2019 01; 51(1):42-50. PMID: 30455415.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  12. Lino Cardenas CL, Kessinger CW, MacDonald C, Jassar AS, Isselbacher EM, Jaffer FA, Lindsay ME. Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm. JCI Insight. 2018 03 08; 3(5). PMID: 29515022.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  13. Lino Cardenas CL, Kessinger CW, Cheng Y, MacDonald C, MacGillivray T, Ghoshhajra B, Huleihel L, Nuri S, Yeri AS, Jaffer FA, Kaminski N, Ellinor P, Weintraub NL, Malhotra R, Isselbacher EM, Lindsay ME. An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm. Nat Commun. 2018 03 08; 9(1):1009. PMID: 29520069.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  14. Boileau A, Lino Cardenas CL, Lindsay ME, Devaux Y. Endogenous Heparin Interferes with Quantification of MicroRNAs by RT-qPCR. Clin Chem. 2018 05; 64(5):863-865. PMID: 29483106.
    Citations: 4     Fields:    Translation:Humans
  15. G. Savary, M. Buscot , E. Dewaeles , S. Diazzi, N. Nottet , E. Courcot ,J. Fassy , K. Lebrigand , I. S. Henaoui , N. Martis , C. Van der Hauwaert , S. Leroy, L. Plantier , A. Paquet , C. L. Lino Cardenas , G. Vassaux , B. Crestani , B. Wallaert , R. Rezzonico , T. Brousseau , F. Glowacki, S. Bellusci , M. Perrais, F. Broly , P. Barbry , C. H. Marquette , C. Cauffiez , B. Mari and N. Pottier. Targeting the DNM3OS / miR-199a~214 cluster for the treatment of fibroproliferative diseases. 2018; 10(242040):1101. View Publication.
  16. Rondón-Ortiz AN, Lino Cardenas CL, Martínez-Málaga J, Gonzales-Urday AL, Gugnani KS, Böhlke M, Maher TJ, Pino-Figueroa AJ. High Concentrations of Rosiglitazone Reduce mRNA and Protein Levels of LRP1 in HepG2 Cells. Front Pharmacol. 2017; 8:772. PMID: 29201005.
    Citations: 3     
  17. Tzouvelekis A, Yu G, Lino Cardenas CL, Herazo-Maya JD, Wang R, Woolard T, Zhang Y, Sakamoto K, Lee H, Yi JS, DeIuliis G, Xylourgidis N, Ahangari F, Lee PJ, Aidinis V, Herzog EL, Homer R, Bennett AM, Kaminski N. SH2 Domain-Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis. Am J Respir Crit Care Med. 2017 Feb 15; 195(4):500-514. PMID: 27736153.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  18. Isselbacher EM, Lino Cardenas CL, Lindsay ME. Hereditary Influence in Thoracic Aortic Aneurysm and Dissection. Circulation. 2016 Jun 14; 133(24):2516-28. PMID: 27297344.
    Citations: 36     Fields:    Translation:Humans
  19. Bustos ML, Huleihel L, Kapetanaki MG, Lino-Cardenas CL, Mroz L, Ellis BM, McVerry BJ, Richards TJ, Kaminski N, Cerdenes N, Mora AL, Rojas M. Aging mesenchymal stem cells fail to protect because of impaired migration and antiinflammatory response. Am J Respir Crit Care Med. 2014 Apr 01; 189(7):787-98. PMID: 24559482.
    Citations: 69     Fields:    Translation:AnimalsCells
  20. Schulz MH, Pandit KV, Lino Cardenas CL, Ambalavanan N, Kaminski N, Bar-Joseph Z. Reconstructing dynamic microRNA-regulated interaction networks. Proc Natl Acad Sci U S A. 2013 Sep 24; 110(39):15686-91. PMID: 23986498.
    Citations: 29     Fields:    Translation:HumansAnimals
  21. Lino Cardenas CL, Henaoui IS, Courcot E, Roderburg C, Cauffiez C, Aubert S, Copin MC, Wallaert B, Glowacki F, Dewaeles E, Milosevic J, Maurizio J, Tedrow J, Marcet B, Lo-Guidice JM, Kaminski N, Barbry P, Luedde T, Perrais M, Mari B, Pottier N. miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1. PLoS Genet. 2013; 9(2):e1003291. PMID: 23459460.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  22. Lino Cardenas CL, Kaminski N, Kass DJ. Micromanaging microRNAs: using murine models to study microRNAs in lung fibrosis. Drug Discov Today Dis Models. 2013; 10(3):e145-e151. PMID: 25328532.
    Citations: 7     
  23. Lino Cardenas CL, Renault N, Farce A, Cauffiez C, Allorge D, Lo-Guidice JM, Lhermitte M, Chavatte P, Broly F, Chevalier D. Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population. Gene. 2011 Nov 01; 487(1):10-20. PMID: 21820496.
    Citations: 3     Fields:    Translation:HumansCells
  24. Lino Cardenas CL, Devos A, Toure A, Cardenas Garcia J, Kenani A, Migot-Nabias F, Broly F, Chevalier D. Arachidonic acid ?-hydroxylase CYP4A11: inter-ethnic variations in the 8590T>C loss-of-function variant. Mol Biol Rep. 2012 Feb; 39(2):1503-8. PMID: 21617944.
    Citations: 4     Fields:    Translation:HumansCells
  25. Garat A, Cardenas CL, Lionet A, Devos A, Glowacki F, Kenani A, Migot-Nabias F, Allorge D, Lo-Guidice JM, Broly F, Cauffiez C. Inter-ethnic variability of three functional polymorphisms affecting the IMPDH2 gene. Mol Biol Rep. 2011 Nov; 38(8):5185-8. PMID: 21181270.
    Citations: 2     Fields:    Translation:Humans
  26. Lino Cardenas CL, Bourgine J, Cauffiez C, Allorge D, Lo-Guidice JM, Broly F, Chevalier D. Genetic polymorphisms of glycine N-acyltransferase (GLYAT) in a French Caucasian population. Xenobiotica. 2010 Dec; 40(12):853-61. PMID: 20925583.
    Citations: 4     Fields:    Translation:HumansCells
  27. Devos A, Lino Cardenas CL, Glowacki F, Engels A, Lo-Guidice JM, Chevalier D, Allorge D, Broly F, Cauffiez C. Genetic polymorphism of CYP2U1, a cytochrome P450 involved in fatty acids hydroxylation. Prostaglandins Leukot Essent Fatty Acids. 2010 Aug; 83(2):105-10. PMID: 20630735.
    Citations: 7     Fields:    Translation:HumansCells
  28. Pottier N, Maurin T, Chevalier B, Puisségur MP, Lebrigand K, Robbe-Sermesant K, Bertero T, Lino Cardenas CL, Courcot E, Rios G, Fourre S, Lo-Guidice JM, Marcet B, Cardinaud B, Barbry P, Mari B. Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial-mesenchymal interactions. PLoS One. 2009 Aug 24; 4(8):e6718. PMID: 19701459.
    Citations: 92     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.