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profileMiles Miller, Ph.D.

TitleInstructor in Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital
Rm 5210
185 Cambridge St
Boston MA 02114
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Conrad C, Dorzweiler K, Miller MA, Lauffenburger DA, Strik H, Bartsch JW. Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis. Fluids Barriers CNS. 2017 Aug 14; 14(1):22. PMID: 28806983.
    View in: PubMed
  2. Miller MA, Askevold B, Mikula H, Kohler RH, Pirovich D, Weissleder R. Nano-palladium is a cellular catalyst for in vivo chemistry. Nat Commun. 2017 Jul 12; 8:15906. PMID: 28699627.
    View in: PubMed
  3. Miller MA, Weissleder R. Imaging of anticancer drug action in single cells. Nat Rev Cancer. 2017 Jun 23; 17(7):399-414. PMID: 28642603.
    View in: PubMed
  4. Miller MA. Driver mutations take the wheel in invasive yet nonmalignant disease. Sci Transl Med. 2017 Jun 07; 9(393). PMID: 28592567.
    View in: PubMed
  5. Miller MA, Chandra R, Cuccarese MF, Pfirschke C, Engblom C, Stapleton S, Adhikary U, Kohler RH, Mohan JF, Pittet MJ, Weissleder R. Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts. Sci Transl Med. 2017 May 31; 9(392). PMID: 28566423.
    View in: PubMed
  6. Arlauckas SP, Garris CS, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ. In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy. Sci Transl Med. 2017 May 10; 9(389). PMID: 28490665.
    View in: PubMed
  7. Miller MA. Richer data with personalized GEMs. Sci Transl Med. 2017 Mar 15; 9(381). PMID: 28298424.
    View in: PubMed
  8. Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R. Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nat Commun. 2017 Feb 08; 8:14293. PMID: 28176769.
    View in: PubMed
  9. Conrad C, Miller MA, Bartsch JW, Schlomann U, Lauffenburger DA. Simultaneous Detection of Metalloprotease Activities in Complex Biological Samples Using the PrAMA (Proteolytic Activity Matrix Assay) Method. Methods Mol Biol. 2017; 1574:243-253. PMID: 28315256.
    View in: PubMed
  10. Miller MA, Sullivan RJ, Lauffenburger DA. Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer. Clin Cancer Res. 2017 Feb 01; 23(3):623-629. PMID: 27895032.
    View in: PubMed
  11. Oudin MJ, Barbier L, Schäfer C, Kosciuk T, Miller MA, Han S, Jonas O, Lauffenburger DA, Gertler FB. MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer. Mol Cancer Ther. 2017 Jan; 16(1):143-155. PMID: 27811011.
    View in: PubMed
  12. Moss ML, Miller MA, Vujanovic N, Yoneyama T, Rasmussen FH. Fluorescent substrates for ADAM15 useful for assaying and high throughput screening. Anal Biochem. 2016 Dec 01; 514:42-47. PMID: 27637923.
    View in: PubMed
  13. Oudin MJ, Miller MA, Klazen JA, Kosciuk T, Lussiez A, Hughes SK, Tadros J, Bear JE, Lauffenburger DA, Gertler FB. MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis. Mol Biol Cell. 2016 Oct 15; 27(20):3085-3094. PMID: 27559126.
    View in: PubMed
  14. Miller MA, Weissleder R. Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior. Adv Drug Deliv Rev. 2017 Apr; 113:61-86. PMID: 27266447.
    View in: PubMed
  15. Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA. Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance. Cancer Discov. 2016 Apr; 6(4):382-99. PMID: 26984351.
    View in: PubMed
  16. Ng EX, Miller MA, Jing T, Chen CH. Single cell multiplexed assay for proteolytic activity using droplet microfluidics. Biosens Bioelectron. 2016 Jul 15; 81:408-414. PMID: 26995287.
    View in: PubMed
  17. Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamaly N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R. Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle. Sci Transl Med. 2015 Nov 18; 7(314):314ra183. PMID: 26582898.
    View in: PubMed
  18. Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R. Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug. Nat Commun. 2015 Oct 27; 6:8692. PMID: 26503691; PMCID: PMC4711745.
  19. Miller MA, Moss ML, Powell G, Petrovich R, Edwards L, Meyer AS, Griffith LG, Lauffenburger DA. Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain. Sci Rep. 2015 Oct 19; 5:15150. PMID: 26477568; PMCID: PMC4609913.
  20. Vinegoni C, Dubach JM, Thurber GM, Miller MA, Mazitschek R, Weissleder R. Advances in measuring single-cell pharmacology in vivo. Drug Discov Today. 2015 Sep; 20(9):1087-92. PMID: 26024776; PMCID: PMC4567932 [Available on 09/01/16].
  21. Ng EX, Miller MA, Jing T, Lauffenburger DA, Chen CH. Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array. Lab Chip. 2015 Feb 21; 15(4):1153-9. PMID: 25553996.
    View in: PubMed
  22. Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia AM, Höfling S, Parsons M, Costa P, Soper R, Bossard M, Hagemann T, Roshani R, Sewald N, Ketchem RR, Moss ML, Rasmussen FH, Miller MA, Lauffenburger DA, Tuveson DA, Nimsky C, Bartsch JW. ADAM8 as a drug target in pancreatic cancer. Nat Commun. 2015 Jan 28; 6:6175. PMID: 25629724; PMCID: PMC5014123.
  23. Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R. Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Sci Transl Med. 2014 Nov 05; 6(261):261ra152. PMID: 25378644; PMCID: PMC4330962.
  24. Turetsky A, Kim E, Kohler RH, Miller MA, Weissleder R. Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor. Sci Rep. 2014 Apr 24; 4:4782. PMID: 24759210; PMCID: PMC3998017.
  25. Miller MA, Askevold B, Yang KS, Kohler RH, Weissleder R. Platinum compounds for high-resolution in vivo cancer imaging. ChemMedChem. 2014 Jun; 9(6):1131-5. PMID: 24504646; PMCID: PMC4037345.
  26. Meyer AS, Miller MA, Gertler FB, Lauffenburger DA. The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells. Sci Signal. 2013 Aug 06; 6(287):ra66. PMID: 23921085; PMCID: PMC3947921.
  27. Dang M, Armbruster N, Miller MA, Cermeno E, Hartmann M, Bell GW, Root DE, Lauffenburger DA, Lodish HF, Herrlich A. Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9776-81. PMID: 23720309; PMCID: PMC3683718.
  28. Miller MA, Meyer AS, Beste MT, Lasisi Z, Reddy S, Jeng KW, Chen CH, Han J, Isaacson K, Griffith LG, Lauffenburger DA. ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):E2074-83. PMID: 23674691; PMCID: PMC3670354.
  29. Chen CH, Miller MA, Sarkar A, Beste MT, Isaacson KB, Lauffenburger DA, Griffith LG, Han J. Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis. J Am Chem Soc. 2013 Feb 06; 135(5):1645-8. PMID: 23157326; PMCID: PMC3566300.
  30. Miller MA, Feng XJ, Li G, Rabitz HA. Identifying biological network structure, predicting network behavior, and classifying network state with High Dimensional Model Representation (HDMR). PLoS One. 2012; 7(6):e37664. PMID: 22723838; PMCID: PMC3377689.
  31. Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, Griffith LG, Lauffenburger DA, Petrovich R, Bartsch JW. ADAM9 inhibition increases membrane activity of ADAM10 and controls a-secretase processing of amyloid precursor protein. J Biol Chem. 2011 Nov 25; 286(47):40443-51. PMID: 21956108; PMCID: PMC3220463.
  32. Chen CH, Sarkar A, Song YA, Miller MA, Kim SJ, Griffith LG, Lauffenburger DA, Han J. Enhancing protease activity assay in droplet-based microfluidics using a biomolecule concentrator. J Am Chem Soc. 2011 Jul 13; 133(27):10368-71. PMID: 21671557; PMCID: PMC3165005.
  33. Miller MA, Barkal L, Jeng K, Herrlich A, Moss M, Griffith LG, Lauffenburger DA. Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities. Integr Biol (Camb). 2011 Apr; 3(4):422-38. PMID: 21180771; PMCID: PMC3173501.
  34. Miller M, Feng X, Li G, Rabitz H. Nonlinear bionetwork structure inference using the random sampling-high dimensional model representation (RS-HDMR) algorithm. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:6412-5. PMID: 19964421.
    View in: PubMed
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