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Miles Miller, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00CA207744 (MILLER, MILES A) Jul 1, 2018 - Jun 30, 2021
    NIH/NCI
    Single Cell In Vivo Imaging Technology to Analyze Taxane Nano Formulations in Breast Cancer
    Role: Principal Investigator
  2. K99CA207744 (MILLER, MILES A) Jul 1, 2016 - Jun 30, 2018
    NIH/NCI
    Single Cell In Vivo Imaging Technology to Analyze Taxane Nano Formulations in Breast Cancer
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Miller MA, Mikula H, Luthria G, Li R, Kronister S, Prytyskach M, Kohler RH, Mitchison T, Weissleder R. Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation. ACS Nano. 2018 Dec 26; 12(12):12814-12826. PMID: 30550257.
    Citations:    Fields:    
  2. Kim HY, Li R, Ng TSC, Courties G, Rodell CB, Prytyskach M, Kohler RH, Pittet MJ, Nahrendorf M, Weissleder R, Miller MA. Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin. ACS Nano. 2018 Dec 26; 12(12):12015-12029. PMID: 30508377.
    Citations:    Fields:    
  3. Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R, Mitchison TJ. Site occupancy calibration of taxane pharmacology in live cells and tissues. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):E11406-E11414. PMID: 30429313.
    Citations:    Fields:    
  4. Ng EX, Sun G, Wei SC, Miller MA, DasGupta R, Lam PYP, Chen CH. Ultrafast Single-Cell Level Enzymatic Tumor Profiling. Anal Chem. 2019 Jan 15; 91(2):1277-1285. PMID: 30362713.
    Citations:    Fields:    
  5. Yoneyama T, Gorry M, Sobo-Vujanovic A, Lin Y, Vujanovic L, Gaither-Davis A, Moss ML, Miller MA, Griffith LG, Lauffenburger DA, Stabile LP, Herman J, Vujanovic NL. ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker. J Cancer. 2018; 9(14):2559-2570. PMID: 30026855.
    Citations: 1     
  6. Miller MA, Kim E, Cuccarese MF, Plotkin AL, Prytyskach M, Kohler RH, Pittet MJ, Weissleder R. Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun (Camb). 2017 Dec 19; 54(1):42-45. PMID: 29185561.
    Citations:    Fields:    Translation:AnimalsCells
  7. Yoneyama T, Gorry M, Miller MA, Gaither-Davis A, Lin Y, Moss ML, Griffith LG, Lauffenburger DA, Stabile LP, Herman JG, Vujanovic NL. Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates. J Cancer. 2017; 8(19):3916-3932. PMID: 29187866.
    Citations: 1     
  8. Conrad C, Dorzweiler K, Miller MA, Lauffenburger DA, Strik H, Bartsch JW. Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis. Fluids Barriers CNS. 2017 Aug 14; 14(1):22. PMID: 28806983.
    Citations: 1     Fields:    Translation:Humans
  9. Miller MA, Askevold B, Mikula H, Kohler RH, Pirovich D, Weissleder R. Nano-palladium is a cellular catalyst for in vivo chemistry. Nat Commun. 2017 07 12; 8:15906. PMID: 28699627.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  10. Miller MA, Arlauckas S, Weissleder R. Prediction of Anti-cancer Nanotherapy Efficacy by Imaging. Nanotheranostics. 2017; 1(3):296-312. PMID: 29071194.
    Citations: 4     
  11. Miller MA, Weissleder R. Imaging of anticancer drug action in single cells. Nat Rev Cancer. 2017 06 23; 17(7):399-414. PMID: 28642603.
    Citations: 5     Fields:    Translation:HumansAnimals
  12. Miller MA. Driver mutations take the wheel in invasive yet nonmalignant disease. Sci Transl Med. 2017 06 07; 9(393). PMID: 28592567.
    Citations:    Fields:    
  13. Miller MA, Chandra R, Cuccarese MF, Pfirschke C, Engblom C, Stapleton S, Adhikary U, Kohler RH, Mohan JF, Pittet MJ, Weissleder R. Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts. Sci Transl Med. 2017 05 31; 9(392). PMID: 28566423.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  14. Arlauckas SP, Garris CS, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ. In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy. Sci Transl Med. 2017 05 10; 9(389). PMID: 28490665.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  15. Miller MA. Nanoparticles improve economic mileage for CARs. Sci Transl Med. 2017 04 26; 9(387). PMID: 28446684.
    Citations:    Fields:    Translation:HumansCells
  16. Miller MA. Richer data with personalized GEMs. Sci Transl Med. 2017 03 15; 9(381). PMID: 28298424.
    Citations:    Fields:    
  17. Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R. Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nat Commun. 2017 02 08; 8:14293. PMID: 28176769.
    Citations:    
  18. Conrad C, Miller MA, Bartsch JW, Schlomann U, Lauffenburger DA. Simultaneous Detection of Metalloprotease Activities in Complex Biological Samples Using the PrAMA (Proteolytic Activity Matrix Assay) Method. Methods Mol Biol. 2017; 1574:243-253. PMID: 28315256.
    Citations: 1     Fields:    Translation:HumansCells
  19. Miller MA, Sullivan RJ, Lauffenburger DA. Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer. Clin Cancer Res. 2017 Feb 01; 23(3):623-629. PMID: 27895032.
    Citations: 4     Fields:    Translation:HumansCells
  20. Oudin MJ, Barbier L, Schäfer C, Kosciuk T, Miller MA, Han S, Jonas O, Lauffenburger DA, Gertler FB. MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer. Mol Cancer Ther. 2017 01; 16(1):143-155. PMID: 27811011.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  21. Moss ML, Miller MA, Vujanovic N, Yoneyama T, Rasmussen FH. Fluorescent substrates for ADAM15 useful for assaying and high throughput screening. Anal Biochem. 2016 12 01; 514:42-47. PMID: 27637923.
    Citations:    Fields:    Translation:HumansCells
  22. Oudin MJ, Miller MA, Klazen JA, Kosciuk T, Lussiez A, Hughes SK, Tadros J, Bear JE, Lauffenburger DA, Gertler FB. MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis. Mol Biol Cell. 2016 10 15; 27(20):3085-3094. PMID: 27559126.
    Citations: 1     Fields:    Translation:AnimalsCells
  23. Miller MA, Weissleder R. Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior. Adv Drug Deliv Rev. 2017 04; 113:61-86. PMID: 27266447.
    Citations: 2     Fields:    Translation:Humans
  24. Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA. Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance. Cancer Discov. 2016 Apr; 6(4):382-99. PMID: 26984351.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  25. Ng EX, Miller MA, Jing T, Chen CH. Single cell multiplexed assay for proteolytic activity using droplet microfluidics. Biosens Bioelectron. 2016 Jul 15; 81:408-414. PMID: 26995287.
    Citations: 5     Fields:    Translation:HumansCells
  26. Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamaly N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R. Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle. Sci Transl Med. 2015 Nov 18; 7(314):314ra183. PMID: 26582898.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  27. Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R. Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug. Nat Commun. 2015 Oct 27; 6:8692. PMID: 26503691.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  28. Miller MA, Moss ML, Powell G, Petrovich R, Edwards L, Meyer AS, Griffith LG, Lauffenburger DA. Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain. Sci Rep. 2015 Oct 19; 5:15150. PMID: 26477568.
    Citations: 6     Fields:    Translation:HumansCells
  29. Vinegoni C, Dubach JM, Thurber GM, Miller MA, Mazitschek R, Weissleder R. Advances in measuring single-cell pharmacology in vivo. Drug Discov Today. 2015 Sep; 20(9):1087-92. PMID: 26024776.
    Citations: 8     Fields:    Translation:HumansAnimals
  30. Ng EX, Miller MA, Jing T, Lauffenburger DA, Chen CH. Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array. Lab Chip. 2015 Feb 21; 15(4):1153-9. PMID: 25553996.
    Citations: 2     Fields:    Translation:HumansCells
  31. Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia AM, Höfling S, Parsons M, Costa P, Soper R, Bossard M, Hagemann T, Roshani R, Sewald N, Ketchem RR, Moss ML, Rasmussen FH, Miller MA, Lauffenburger DA, Tuveson DA, Nimsky C, Bartsch JW. ADAM8 as a drug target in pancreatic cancer. Nat Commun. 2015 Jan 28; 6:6175. PMID: 25629724.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  32. Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R. Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Sci Transl Med. 2014 Nov 05; 6(261):261ra152. PMID: 25378644.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  33. Turetsky A, Kim E, Kohler RH, Miller MA, Weissleder R. Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor. Sci Rep. 2014 Apr 24; 4:4782. PMID: 24759210.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  34. Miller MA, Askevold B, Yang KS, Kohler RH, Weissleder R. Platinum compounds for high-resolution in vivo cancer imaging. ChemMedChem. 2014 Jun; 9(6):1131-5. PMID: 24504646.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  35. Meyer AS, Miller MA, Gertler FB, Lauffenburger DA. The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells. Sci Signal. 2013 Aug 06; 6(287):ra66. PMID: 23921085.
    Citations: 72     Fields:    Translation:HumansCells
  36. Dang M, Armbruster N, Miller MA, Cermeno E, Hartmann M, Bell GW, Root DE, Lauffenburger DA, Lodish HF, Herrlich A. Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9776-81. PMID: 23720309.
    Citations: 23     Fields:    Translation:HumansCells
  37. Miller MA, Meyer AS, Beste MT, Lasisi Z, Reddy S, Jeng KW, Chen CH, Han J, Isaacson K, Griffith LG, Lauffenburger DA. ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):E2074-83. PMID: 23674691.
    Citations: 25     Fields:    Translation:HumansCells
  38. Chen CH, Miller MA, Sarkar A, Beste MT, Isaacson KB, Lauffenburger DA, Griffith LG, Han J. Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis. J Am Chem Soc. 2013 Feb 06; 135(5):1645-8. PMID: 23157326.
    Citations: 15     Fields:    Translation:HumansCells
  39. Miller MA, Feng XJ, Li G, Rabitz HA. Identifying biological network structure, predicting network behavior, and classifying network state with High Dimensional Model Representation (HDMR). PLoS One. 2012; 7(6):e37664. PMID: 22723838.
    Citations: 5     Fields:    Translation:Cells
  40. Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, Griffith LG, Lauffenburger DA, Petrovich R, Bartsch JW. ADAM9 inhibition increases membrane activity of ADAM10 and controls a-secretase processing of amyloid precursor protein. J Biol Chem. 2011 Nov 25; 286(47):40443-51. PMID: 21956108.
    Citations: 18     Fields:    Translation:HumansCells
  41. Chen CH, Sarkar A, Song YA, Miller MA, Kim SJ, Griffith LG, Lauffenburger DA, Han J. Enhancing protease activity assay in droplet-based microfluidics using a biomolecule concentrator. J Am Chem Soc. 2011 Jul 13; 133(27):10368-71. PMID: 21671557.
    Citations: 9     Fields:    Translation:AnimalsCells
  42. Miller MA, Barkal L, Jeng K, Herrlich A, Moss M, Griffith LG, Lauffenburger DA. Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities. Integr Biol (Camb). 2011 Apr; 3(4):422-38. PMID: 21180771.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  43. Miller M, Feng X, Li G, Rabitz H. Nonlinear bionetwork structure inference using the random sampling-high dimensional model representation (RS-HDMR) algorithm. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:6412-5. PMID: 19964421.
    Citations:    Fields:    Translation:Cells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.