Harvard Catalyst Profiles

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Jose Ricardo McFaline Figueroa, M.D.,Ph.D.

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University of Puerto Rico at Mayaguez, Mayaguez, PRBSChemistry
Columbia University in the City of New York, New York, NYMD, PhDMedicine and Cellular Biology
Massachusetts General Hospital, Boston, MAIntern in Intermal Medicine
Brigham and Women's Hospital/Massachusetts General Hospital, Boston, MAResident in Neurology
Massachusetts General Hospital/Dana-Farber Cancer Institute, Boston, MAFellow in Neuro-Oncology
Harvard T.H. Chan School of Public Health, Boston, MACertificateProgram in Clinical Effectiveness
Premio al Mejor Estudiante de Química
Gran Premio Luis Stefani Rafucci, UPRM
Premio del Colegio de Artes y Ciencias, UPRM
Premio Antoine Laurent Lavoisier, UPRM Dept. of Chemistry
Ruth L. Kirchstein Predoctoral Individual National Research Service Award (F31)
NHLBI Mitochondrial Biology Symposium Travel and Oral Presentation Award
Alpha Omega Alpha Honor Medical Society, Columbia University
AAN Student Prize for Excellence in Neurology
Doctors William Nastuk, Beatrice Seagal and Konrad Hsu Award, Columbia University
NCI Paul Calabresi Clinical Oncology Award (K12)
Sharpe-National Brain Tumor Society 2019-2020 GBM Research Award
DF/HCC SPORE in Brain Cancer Career Enhancement Program Award
Neuro-Oncology Fellowship Teacher of the Year

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 78301 (Jose McFaline-Figueroa) Jan 1, 2021 - Dec 31, 2024
    Harold Amos Medical Faculty Development Program, Robert Wood Johnson Foundation
    The role of CDK4/6 signaling in glioblastoma immune evasion and therapeutic resistance
    Role: Principal Investigator
  2. 5P50CA165962 (Batchelor, Tracy) Nov 1, 2019 - Aug 31, 2022
    Integrating PI3K/Akt/mTOR inhibition and immunotherapy in glioblastoma (CEP), Project 3 Targeting CDK4/6 to Modulate the Immunogenicity in Gliomas (Div. Supp.)
    Role: Career Enhancement Program awardee (11/19-8/20), NCI Diversity Supplement Investigator (9/20-8/22)
  3. Sharpe-NBTS 2019-2020 GBM Research Award (MCFALINE FIGUEROA, JOSE RICARDO) Mar 28, 2019 - Sep 6, 2021
    National Brain Tumor Society
    Integrating CDK4/6 inhibition and immunotherapy for glioblastoma using humanized mouse models
    Role: Principal Investigator
  4. K12CA090354 (Batchelor, Tracy) Jul 1, 2018 - Jun 30, 2020
    CDK4/6 inhibition in the treatment of high-grade gliomas
    Role: Scholar
  5. F31AG034835 (MCFALINE FIGUEROA, JOSE RICARDO) Aug 1, 2009 - Jul 31, 2014
    Cell polarity and aging
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lim-Fat MJ, Youssef GC, Touat M, Iorgulescu JB, Whorral S, Allen M, Rahman R, Chukwueke U, McFaline-Figueroa JR, Nayak L, Lee EQ, Batchelor TT, Arnaout O, Peruzzi PP, Chiocca EA, Reardon DA, Meredith D, Santagata S, Beroukhim R, Bi WL, Ligon KL, Wen PY. Clinical utility of targeted next-generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making. Neuro Oncol. 2022 07 01; 24(7):1140-1149. PMID: 34878541; PMCID: PMC9248387.
    Citations: 4     Fields:    Translation:Humans
  2. McFaline-Figueroa JR, Kaley TJ, Dunn IF, Bi WL. Biology and Treatment of Meningiomas: A Reappraisal. Hematol Oncol Clin North Am. 2022 02; 36(1):133-146. PMID: 34801160.
    Citations:    Fields:    Translation:Humans
  3. Bi WL, Nayak L, Meredith DM, Driver J, Du Z, Hoffman S, Li Y, Lee EQ, Beroukhim R, Rinne M, McFaline-Figueroa R, Chukwueke U, McCluskey C, Gaffey S, Cherniack AD, Stefanik J, Doherty L, Taubert C, Cifrino M, LaFrankie D, Graillon T, Wen PY, Ligon KL, Al-Mefty O, Huang RY, Muzikansky A, Chiocca EA, Santagata S, Dunn IF, Reardon DA. Activity of PD-1 blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results. Neuro Oncol. 2022 01 05; 24(1):101-113. PMID: 34015129; PMCID: PMC8730772.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  4. Xie S, Ni J, McFaline-Figueroa JR, Wang Y, Bronson RT, Ligon KL, Wen PY, Roberts TM, Zhao JJ. Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas. Cell Rep. 2020 09 29; 32(13):108196. PMID: 32997991.
    Citations: 5     Fields:    Translation:HumansAnimals
  5. Touat M, Li YY, Boynton AN, Spurr LF, Iorgulescu JB, Bohrson CL, Cortes-Ciriano I, Birzu C, Geduldig JE, Pelton K, Lim-Fat MJ, Pal S, Ferrer-Luna R, Ramkissoon SH, Dubois F, Bellamy C, Currimjee N, Bonardi J, Qian K, Ho P, Malinowski S, Taquet L, Jones RE, Shetty A, Chow KH, Sharaf R, Pavlick D, Albacker LA, Younan N, Baldini C, Verreault M, Giry M, Guillerm E, Ammari S, Beuvon F, Mokhtari K, Alentorn A, Dehais C, Houillier C, Laigle-Donadey F, Psimaras D, Lee EQ, Nayak L, McFaline-Figueroa JR, Carpentier A, Cornu P, Capelle L, Mathon B, Barnholtz-Sloan JS, Chakravarti A, Bi WL, Chiocca EA, Fehnel KP, Alexandrescu S, Chi SN, Haas-Kogan D, Batchelor TT, Frampton GM, Alexander BM, Huang RY, Ligon AH, Coulet F, Delattre JY, Hoang-Xuan K, Meredith DM, Santagata S, Duval A, Sanson M, Cherniack AD, Wen PY, Reardon DA, Marabelle A, Park PJ, Idbaih A, Beroukhim R, Bandopadhayay P, Bielle F, Ligon KL. Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 04; 580(7804):517-523. PMID: 32322066; PMCID: PMC8235024.
    Citations: 130     Fields:    Translation:HumansAnimalsCells
  6. Zhang M, Young GS, Chen H, Li J, Qin L, McFaline-Figueroa JR, Reardon DA, Cao X, Wu X, Xu X. Deep-Learning Detection of Cancer Metastases to the Brain on MRI. J Magn Reson Imaging. 2020 10; 52(4):1227-1236. PMID: 32167652.
    Citations: 14     Fields:    Translation:Humans
  7. Lim-Fat MJ, Bi WL, Lo J, Lee EQ, Ahluwalia MS, Batchelor TT, Chang SM, Chiocca EA, Chukwueke U, Cloughesy TF, Colman H, Deangelis LM, Galanis E, Gilbert MR, De Groot JF, Lassman AB, Liau LM, Mason W, McFaline-Figueroa JR, Mehta MP, Mellinghoff IK, Nabors LB, Nayak L, Reardon DA, Wen PY. Letter: When Less is More: Dexamethasone Dosing for Brain Tumors. Neurosurgery. 2019 09 01; 85(3):E607-E608. PMID: 31215634.
    Citations: 2     Fields:    
  8. Yanagihara TK, McFaline-Figueroa JR, Giacalone NJ, Lee AW, Soni V, Hwang ME, Hsieh KT, Saraf A, Wu CC, Yang D, Wen PY, Ashamalla H, Aizer AA, Wang TJC, Huang RY. A low percentage of metastases in deep brain and temporal lobe structures. Neuro Oncol. 2019 05 06; 21(5):640-647. PMID: 30715520; PMCID: PMC6502494.
    Citations: 5     Fields:    Translation:Humans
  9. Lee EQ, McFaline-Figueroa JR, Cloughesy TF, Wen PY. Is it time to reconsider the role of irinotecan for the treatment of high-grade gliomas? Neuro Oncol. 2018 07 05; 20(8):1144. PMID: 29955870; PMCID: PMC6280142.
    Citations: 1     Fields:    Translation:Humans
  10. McFaline-Figueroa JR, Lee EQ. Brain Tumors. Am J Med. 2018 08; 131(8):874-882. PMID: 29371158.
    Citations: 26     Fields:    Translation:Humans
  11. O'Donnell-Luria AH, Lin AP, Merugumala SK, Rohr F, Waisbren SE, Lynch R, Tchekmedyian V, Goldberg AD, Bellinger A, McFaline-Figueroa JR, Simon T, Gershanik EF, Levy BD, Cohen DE, Samuels MA, Berry GT, Frank NY. Brain MRS glutamine as a biomarker to guide therapy of hyperammonemic coma. Mol Genet Metab. 2017 05; 121(1):9-15. PMID: 28408159.
    Citations: 4     Fields:    Translation:Humans
  12. McFaline-Figueroa JR, Wen PY. The Viral Connection to Glioblastoma. Curr Infect Dis Rep. 2017 Feb; 19(2):5. PMID: 28233187.
    Citations: 13     
  13. McInnes J, Rehders M, McFaline-Figueroa JR, Brix K, Pon LA, Nevoigt E. Defects in mitochondrial distribution during the prolonged lag phase of Saccharomyces cerevisiae preceding growth in glycerol as the sole source of carbon. FEMS Yeast Res. 2013 Nov; 13(7):706-10. PMID: 24020807.
    Citations: 2     Fields:    Translation:AnimalsCells
  14. Swayne TC, Zhou C, Boldogh IR, Charalel JK, McFaline-Figueroa JR, Thoms S, Yang C, Leung G, McInnes J, Erdmann R, Pon LA. Role for cER and Mmr1p in anchorage of mitochondria at sites of polarized surface growth in budding yeast. Curr Biol. 2011 Dec 06; 21(23):1994-9. PMID: 22119524.
    Citations: 48     Fields:    Translation:AnimalsCells
  15. McFaline-Figueroa JR, Vevea J, Swayne TC, Zhou C, Liu C, Leung G, Boldogh IR, Pon LA. Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast. Aging Cell. 2011 Oct; 10(5):885-95. PMID: 21726403.
    Citations: 95     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.