Harvard Catalyst Profiles

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William Allen Freed-Pastor, M.D., Ph.D.

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Titus Munson Coan Prize
The Robert F. Loeb Award
Alpha Omega Alpha
John S. Newberry Prize
Columbia Dean’s Day of Research Award
International p53 Workshop Outstanding Poster Award
Phi Beta Kappa

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris JP, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp-Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, de Stanchina E, Zender L, Tong DR, D'Alessandro A, Lowe SW, Prives C. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. 2019 01 24; 176(3):564-580.e19. PMID: 30580964.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  2. Rastogi C, Rube HT, Kribelbauer JF, Crocker J, Loker RE, Martini GD, Laptenko O, Freed-Pastor WA, Prives C, Stern DL, Mann RS, Bussemaker HJ. Accurate and sensitive quantification of protein-DNA binding affinity. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3692-E3701. PMID: 29610332.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  3. Kribelbauer JF, Laptenko O, Chen S, Martini GD, Freed-Pastor WA, Prives C, Mann RS, Bussemaker HJ. Quantitative Analysis of the DNA Methylation Sensitivity of Transcription Factor Complexes. Cell Rep. 2017 06 13; 19(11):2383-2395. PMID: 28614722.
    Citations: 29     Fields:    Translation:HumansCells
  4. Freed-Pastor W, Prives C. Targeting mutant p53 through the mevalonate pathway. Nat Cell Biol. 2016 Oct 27; 18(11):1122-1124. PMID: 27784901.
    Citations: 9     Fields:    Translation:HumansAnimals
  5. Pfister NT, Fomin V, Regunath K, Zhou JY, Zhou W, Silwal-Pandit L, Freed-Pastor WA, Laptenko O, Neo SP, Bargonetti J, Hoque M, Tian B, Gunaratne J, Engebraaten O, Manley JL, Børresen-Dale AL, Neilsen PM, Prives C. Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells. Genes Dev. 2015 Jun 15; 29(12):1298-315. PMID: 26080815.
    Citations: 49     Fields:    Translation:HumansCells
  6. Laptenko O, Shiff I, Freed-Pastor W, Zupnick A, Mattia M, Freulich E, Shamir I, Kadouri N, Kahan T, Manfredi J, Simon I, Prives C. The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain. Mol Cell. 2015 Mar 19; 57(6):1034-1046. PMID: 25794615.
    Citations: 36     Fields:    Translation:HumansCells
  7. Freed-Pastor WA, Prives C. Mutant p53: one name, many proteins. Genes Dev. 2012 Jun 15; 26(12):1268-86. PMID: 22713868.
    Citations: 469     Fields:    Translation:HumansCells
  8. Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, Bissell MJ, Osborne TF, Tian B, Lowe SW, Silva JM, Børresen-Dale AL, Levine AJ, Bargonetti J, Prives C. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell. 2012 Jan 20; 148(1-2):244-58. PMID: 22265415.
    Citations: 349     Fields:    Translation:HumansCells
  9. Freed-Pastor WA, Prives C. Dissimilar DNA binding by p53 in normal and tumor-derived cells. . 2011 Dec 15; 10(24):4207. PMID: 22127203.
    Citations: 3     Translation:Humans
  10. Kass EM, Ahn J, Tanaka T, Freed-Pastor WA, Keezer S, Prives C. Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456. J Biol Chem. 2007 Oct 12; 282(41):30311-21. PMID: 17715138.
    Citations: 13     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.