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William Allen Freed-Pastor, M.D., Ph.D.

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Case Western Reserve University, Cleveland, OHBS05/2006Biochemistry
Case Western Reserve University, Cleveland, OHBA05/2006Religious Studies
Columbia University College of Physicians and Surgeons, New York, NYMD, PhD05/2013Biological Sciences, Medicine
Massachusetts General Hospital, Boston, MA06/2015Internal Medicine (Residency)
Dana-Farber Cancer Institute, Boston, MA12/2020Medical Oncology (Fellowship)
Titus Munson Coan Prize
The Robert F. Loeb Award
Alpha Omega Alpha
John S. Newberry Prize
Columbia Dean’s Day of Research Award
International p53 Workshop Outstanding Poster Award
Phi Beta Kappa
2019 - 2020
SU2C Golden Arrow Early Career Scientist Award
2019 - 2020
GI SPORE Career Enhancement Award
2020 - 2022
SU2C Phillip A. Sharp Innovation in Collaboration Award
2021 - 2022
ASCO Young Investigator Award
2022 - 2027
Career Award for Medical Scientists


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A. Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment. Nat Genet. 2022 08; 54(8):1178-1191. PMID: 35902743.
    Citations:    Fields:    
  2. Jaeger AM, Stopfer LE, Ahn R, Sanders EA, Sandel DA, Freed-Pastor WA, Rideout WM, Naranjo S, Fessenden T, Nguyen KB, Winter PS, Kohn RE, Westcott PMK, Schenkel JM, Shanahan SL, Shalek AK, Spranger S, White FM, Jacks T. Deciphering the immunopeptidome in vivo reveals new tumour antigens. Nature. 2022 07; 607(7917):149-155. PMID: 35705813.
    Citations:    Fields:    Translation:AnimalsCells
  3. Yang D, Jones MG, Naranjo S, Rideout WM, Min KHJ, Ho R, Wu W, Replogle JM, Page JL, Quinn JJ, Horns F, Qiu X, Chen MZ, Freed-Pastor WA, McGinnis CS, Patterson DM, Gartner ZJ, Chow ED, Bivona TG, Chan MM, Yosef N, Jacks T, Weissman JS. Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution. Cell. 2022 05 26; 185(11):1905-1923.e25. PMID: 35523183; PMCID: PMC9452598.
    Citations: 2     Fields:    Translation:Animals
  4. Hamza B, Miller AB, Meier L, Stockslager M, Ng SR, King EM, Lin L, DeGouveia KL, Mulugeta N, Calistri NL, Strouf H, Bray C, Rodriguez F, Freed-Pastor WA, Chin CR, Jaramillo GC, Burger ML, Weinberg RA, Shalek AK, Jacks T, Manalis SR. Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice. Nat Commun. 2021 09 28; 12(1):5680. PMID: 34584084.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  5. Schenkel JM, Herbst RH, Canner D, Li A, Hillman M, Shanahan SL, Gibbons G, Smith OC, Kim JY, Westcott P, Hwang WL, Freed-Pastor WA, Eng G, Cuoco MS, Rogers P, Park JK, Burger ML, Rozenblatt-Rosen O, Cong L, Pauken KE, Regev A, Jacks T. Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes. Immunity. 2021 10 12; 54(10):2338-2353.e6. PMID: 34534439; PMCID: PMC8604155.
    Citations: 16     Fields:    Translation:AnimalsCells
  6. Freed-Pastor WA, Lambert LJ, Ely ZA, Pattada NB, Bhutkar A, Eng G, Mercer KL, Garcia AP, Lin L, Rideout WM, Hwang WL, Schenkel JM, Jaeger AM, Bronson RT, Westcott PMK, Hether TD, Divakar P, Reeves JW, Deshpande V, Delorey T, Phillips D, Yilmaz OH, Regev A, Jacks T. The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer. Cancer Cell. 2021 10 11; 39(10):1342-1360.e14. PMID: 34358448; PMCID: PMC8511341.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  7. Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris JP, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp-Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, de Stanchina E, Zender L, Tong DR, D'Alessandro A, Lowe SW, Prives C. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. 2019 01 24; 176(3):564-580.e19. PMID: 30580964.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  8. Rastogi C, Rube HT, Kribelbauer JF, Crocker J, Loker RE, Martini GD, Laptenko O, Freed-Pastor WA, Prives C, Stern DL, Mann RS, Bussemaker HJ. Accurate and sensitive quantification of protein-DNA binding affinity. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3692-E3701. PMID: 29610332; PMCID: PMC5910815.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  9. Kribelbauer JF, Laptenko O, Chen S, Martini GD, Freed-Pastor WA, Prives C, Mann RS, Bussemaker HJ. Quantitative Analysis of the DNA Methylation Sensitivity of Transcription Factor Complexes. Cell Rep. 2017 06 13; 19(11):2383-2395. PMID: 28614722.
    Citations: 43     Fields:    Translation:HumansCells
  10. Freed-Pastor W, Prives C. Targeting mutant p53 through the mevalonate pathway. Nat Cell Biol. 2016 Oct 27; 18(11):1122-1124. PMID: 27784901.
    Citations: 13     Fields:    Translation:HumansAnimals
  11. Pfister NT, Fomin V, Regunath K, Zhou JY, Zhou W, Silwal-Pandit L, Freed-Pastor WA, Laptenko O, Neo SP, Bargonetti J, Hoque M, Tian B, Gunaratne J, Engebraaten O, Manley JL, Børresen-Dale AL, Neilsen PM, Prives C. Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells. Genes Dev. 2015 Jun 15; 29(12):1298-315. PMID: 26080815; PMCID: PMC4495400.
    Citations: 65     Fields:    Translation:HumansCells
  12. Laptenko O, Shiff I, Freed-Pastor W, Zupnick A, Mattia M, Freulich E, Shamir I, Kadouri N, Kahan T, Manfredi J, Simon I, Prives C. The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain. Mol Cell. 2015 Mar 19; 57(6):1034-1046. PMID: 25794615; PMCID: PMC6221458.
    Citations: 56     Fields:    Translation:HumansCells
  13. Freed-Pastor WA, Prives C. Mutant p53: one name, many proteins. Genes Dev. 2012 Jun 15; 26(12):1268-86. PMID: 22713868.
    Citations: 575     Fields:    Translation:HumansCells
  14. Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, Bissell MJ, Osborne TF, Tian B, Lowe SW, Silva JM, Børresen-Dale AL, Levine AJ, Bargonetti J, Prives C. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell. 2012 Jan 20; 148(1-2):244-58. PMID: 22265415.
    Citations: 425     Fields:    Translation:HumansCells
  15. Freed-Pastor WA, Prives C. Dissimilar DNA binding by p53 in normal and tumor-derived cells. Cell Cycle. 2011 Dec 15; 10(24):4207. PMID: 22127203.
    Citations: 3     Fields:    Translation:Humans
  16. Kass EM, Ahn J, Tanaka T, Freed-Pastor WA, Keezer S, Prives C. Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456. J Biol Chem. 2007 Oct 12; 282(41):30311-21. PMID: 17715138.
    Citations: 14     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.