Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jose Miguel Orozco, Ph.D.

Title
Institution
Department
Address

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F30CA210373 (OROZCO, JOSE MIGUEL) Sep 1, 2016 - Aug 31, 2019
    NIH
    Determining the mechanism of aspartate sensing by the mTOR pathway
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Condon KJ, Orozco JM, Adelmann CH, Spinelli JB, van der Helm PW, Roberts JM, Kunchok T, Sabatini DM. Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction. Proc Natl Acad Sci U S A. 2021 01 26; 118(4). PMID: 33483422; PMCID: PMC7848693.
    Citations: 18     Fields:    Translation:HumansCells
  2. Orozco JM, Krawczyk PA, Scaria SM, Cangelosi AL, Chan SH, Kunchok T, Lewis CA, Sabatini DM. Dihydroxyacetone phosphate signals glucose availability to mTORC1. Nat Metab. 2020 09; 2(9):893-901. PMID: 32719541; PMCID: PMC7995735.
    Citations: 46     Fields:    Translation:HumansCells
  3. Gu X, Orozco JM, Saxton RA, Condon KJ, Liu GY, Krawczyk PA, Scaria SM, Harper JW, Gygi SP, Sabatini DM. SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway. Science. 2017 11 10; 358(6364):813-818. PMID: 29123071; PMCID: PMC5747364.
    Citations: 171     Fields:    Translation:HumansCells
  4. Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017 03 16; 543(7645):438-442. PMID: 28199306; PMCID: PMC5360989.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  5. Tavares CD, Sharabi K, Dominy JE, Lee Y, Isasa M, Orozco JM, Jedrychowski MP, Kamenecka TM, Griffin PR, Gygi SP, Puigserver P. The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1a Transcriptional Coactivator. J Biol Chem. 2016 May 13; 291(20):10635-45. PMID: 27022023.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  6. Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, Spooner E, Isasa M, Gygi SP, Sabatini DM. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep. 2014 Oct 09; 9(1):1-8. PMID: 25263562; PMCID: PMC4223866.
    Citations: 192     Fields:    Translation:HumansCells
  7. Parker SC, Stitzel ML, Taylor DL, Orozco JM, Erdos MR, Akiyama JA, van Bueren KL, Chines PS, Narisu N, Black BL, Visel A, Pennacchio LA, Collins FS. Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17921-6. PMID: 24127591; PMCID: PMC3816444.
    Citations: 365     Fields:    Translation:HumansAnimalsCells
  8. Kovacevic I, Orozco JM, Cram EJ. Filamin and phospholipase C-e are required for calcium signaling in the Caenorhabditis elegans spermatheca. PLoS Genet. 2013 May; 9(5):e1003510. PMID: 23671426; PMCID: PMC3650001.
    Citations: 26     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Orozco's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (78)
Explore
_
Co-Authors (8)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.