Harvard Catalyst Profiles

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Christoph Michael Ernst, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Slavetinsky CJ, Hauser JN, Gekeler C, Slavetinsky J, Geyer A, Kraus A, Heilingbrunner D, Wagner S, Tesar M, Krismer B, Kuhn S, Ernst CM, Peschel A. Sensitizing Staphylococcus aureus to antibacterial agents by decoding and blocking the lipid flippase MprF. Elife. 2022 01 19; 11. PMID: 35044295; PMCID: PMC8806190.
    Citations: 1     Fields:    Translation:Cells
  2. Rammell NF, Dennert AM, Ernst CM, Reynolds JD. Effects of spawning Pacific salmon on terrestrial invertebrates: Insects near spawning habitat are isotopically enriched with nitrogen-15 but display no differences in body size. Ecol Evol. 2021 Sep; 11(18):12728-12738. PMID: 34594534.
  3. Ma P, He LL, Pironti A, Laibinis HH, Ernst CM, Manson AL, Bhattacharyya RP, Earl AM, Livny J, Hung DT. Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics. Elife. 2021 04 19; 10. PMID: 33871353; PMCID: PMC8079144.
    Citations: 3     Fields:    Translation:Cells
  4. Ernst CM, Braxton JR, Rodriguez-Osorio CA, Zagieboylo AP, Li L, Pironti A, Manson AL, Nair AV, Benson M, Cummins K, Clatworthy AE, Earl AM, Cosimi LA, Hung DT. Author Correction: Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae. Nat Med. 2020 Aug; 26(8):1307. PMID: 32587394; PMCID: PMC9274289.
    Citations:    Fields:    
  5. Ernst CM, Braxton JR, Rodriguez-Osorio CA, Zagieboylo AP, Li L, Pironti A, Manson AL, Nair AV, Benson M, Cummins K, Clatworthy AE, Earl AM, Cosimi LA, Hung DT. Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae. Nat Med. 2020 05; 26(5):705-711. PMID: 32284589; PMCID: PMC9194776.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  6. Obrist DS, Hanly PJ, Kennedy JC, Fitzpatrick OT, Wickham SB, Ernst CM, Nijland W, Reshitnyk LY, Darimont CT, Starzomski BM, Reynolds JD. Marine subsidies mediate patterns in avian island biogeography. Proc Biol Sci. 2020 03 11; 287(1922):20200108. PMID: 32156206; PMCID: PMC7126081.
    Citations: 2     Fields:    Translation:Animals
  7. Ibrahim TM, Ernst C, Lange A, Hennig S, Boeckler FM. Small-Molecule Intervention At The Dimerization Interface Of Survivin By Novel Rigidized Scaffolds. Drug Des Devel Ther. 2019; 13:4247-4263. PMID: 31908412; PMCID: PMC6927794.
    Citations: 2     Fields:    Translation:HumansCells
  8. Ernst CM, Peschel A. MprF-mediated daptomycin resistance. Int J Med Microbiol. 2019 Jul; 309(5):359-363. PMID: 31182276.
    Citations: 20     Fields:    Translation:HumansCells
  9. Ernst CM, Slavetinsky CJ, Kuhn S, Hauser JN, Nega M, Mishra NN, Gekeler C, Bayer AS, Peschel A. Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance. mBio. 2018 12 18; 9(6). PMID: 30563904; PMCID: PMC6299216.
    Citations: 27     Fields:    Translation:Cells
  10. Parada-Kusz M, Penaranda C, Hagedorn EJ, Clatworthy A, Nair AV, Henninger JE, Ernst C, Li B, Riquelme R, Jijon H, Villablanca EJ, Zon LI, Hung D, Allende ML. Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Dis Model Mech. 2018 11 05; 11(11). PMID: 30266803.
    Citations: 10     Fields:    Translation:AnimalsCells
  11. Ma P, Laibinis HH, Ernst CM, Hung DT. Carbapenem Resistance Caused by High-Level Expression of OXA-663 ß-Lactamase in an OmpK36-Deficient Klebsiella pneumoniae Clinical Isolate. Antimicrob Agents Chemother. 2018 11; 62(11). PMID: 30126962; PMCID: PMC6201135.
    Citations: 4     Fields:    Translation:HumansCells
  12. Ernst C, Heidrich J, Sessler C, Sindlinger J, Schwarzer D, Koch P, Boeckler FM. Switching Between Bicyclic and Linear Peptides - The Sulfhydryl-Specific Linker TPSMB Enables Reversible Cyclization of Peptides. Front Chem. 2018; 6:484. PMID: 30386769; PMCID: PMC6198510.
    Citations: 1     
  13. Ernst C, Sindlinger J, Schwarzer D, Koch P, Boeckler FM. The Symmetric Tetravalent Sulfhydryl-Specific Linker NATBA Facilitates a Combinatorial "Tool Kit" Strategy for Phage Display-Based Selection of Functionalized Bicyclic Peptides. ACS Omega. 2018 Oct 31; 3(10):12361-12368. PMID: 30411004; PMCID: PMC6217522.
    Citations: 3     
  14. Cerqueira GC, Earl AM, Ernst CM, Grad YH, Dekker JP, Feldgarden M, Chapman SB, Reis-Cunha JL, Shea TP, Young S, Zeng Q, Delaney ML, Kim D, Peterson EM, O'Brien TF, Ferraro MJ, Hooper DC, Huang SS, Kirby JE, Onderdonk AB, Birren BW, Hung DT, Cosimi LA, Wortman JR, Murphy CI, Hanage WP. Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks. Proc Natl Acad Sci U S A. 2017 01 31; 114(5):1135-1140. PMID: 28096418; PMCID: PMC5293017.
    Citations: 61     Fields:    Translation:HumansCellsPHPublic Health
  15. Ernst CM, Kuhn S, Slavetinsky CJ, Krismer B, Heilbronner S, Gekeler C, Kraus D, Wagner S, Peschel A. The lipid-modifying multiple peptide resistance factor is an oligomer consisting of distinct interacting synthase and flippase subunits. mBio. 2015 Jan 27; 6(1). PMID: 25626904.
    Citations: 32     Fields:    Translation:HumansCells
  16. Slavetinsky CJ, Peschel A, Ernst CM. Alanyl-phosphatidylglycerol and lysyl-phosphatidylglycerol are translocated by the same MprF flippases and have similar capacities to protect against the antibiotic daptomycin in Staphylococcus aureus. Antimicrob Agents Chemother. 2012 Jul; 56(7):3492-7. PMID: 22491694.
    Citations: 24     Fields:    Translation:Cells
  17. Koprivnjak T, Zhang D, Ernst CM, Peschel A, Nauseef WM, Weiss JP. Characterization of Staphylococcus aureus cardiolipin synthases 1 and 2 and their contribution to accumulation of cardiolipin in stationary phase and within phagocytes. J Bacteriol. 2011 Aug; 193(16):4134-42. PMID: 21665977.
    Citations: 30     Fields:    Translation:HumansCells
  18. Andrä J, Goldmann T, Ernst CM, Peschel A, Gutsmann T. Multiple peptide resistance factor (MprF)-mediated Resistance of Staphylococcus aureus against antimicrobial peptides coincides with a modulated peptide interaction with artificial membranes comprising lysyl-phosphatidylglycerol. J Biol Chem. 2011 May 27; 286(21):18692-700. PMID: 21474443.
    Citations: 36     Fields:    Translation:Cells
  19. Ernst CM, Peschel A. Broad-spectrum antimicrobial peptide resistance by MprF-mediated aminoacylation and flipping of phospholipids. Mol Microbiol. 2011 Apr; 80(2):290-9. PMID: 21306448.
    Citations: 87     Fields:    Translation:Cells
  20. Sievers S, Ernst CM, Geiger T, Hecker M, Wolz C, Becher D, Peschel A. Changing the phospholipid composition of Staphylococcus aureus causes distinct changes in membrane proteome and membrane-sensory regulators. Proteomics. 2010 Apr; 10(8):1685-93. PMID: 20162562.
    Citations: 16     Fields:    Translation:Cells
  21. Ernst CM, Staubitz P, Mishra NN, Yang SJ, Hornig G, Kalbacher H, Bayer AS, Kraus D, Peschel A. The bacterial defensin resistance protein MprF consists of separable domains for lipid lysinylation and antimicrobial peptide repulsion. PLoS Pathog. 2009 Nov; 5(11):e1000660. PMID: 19915718.
    Citations: 133     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.