Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

profileTom Conrad Seegar, Ph.D.

TitleResearch Fellow in Biological Chemistry and Molecular Pharmacology (INT)
InstitutionHarvard Medical School
DepartmentBiological Chemistry & Molecular Pharmacology
AddressHarvard Medical School
B C M P, C1
240 Longwood Ave
Boston MA 02115
vCardDownload vCard (login for email)

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. Structural Basis for Regulated Proteolysis by the a-Secretase ADAM10. Cell. 2017 Dec 14; 171(7):1638-1648.e7. PMID: 29224781.
    View in: PubMed
  2. Suliman M, Santosh V, Seegar TCM, Dalton AC, Schultz KM, Klug CS, Barton WA. Directed evolution provides insight into conformational substrate sampling by SrtA. PLoS One. 2017; 12(8):e0184271. PMID: 28859178.
    View in: PubMed
  3. McMillan BJ, Tibbe C, Drabek AA, Seegar TCM, Blacklow SC, Klein T. Structural Basis for Regulation of ESCRT-III Complexes by Lgd. Cell Rep. 2017 May 30; 19(9):1750-1757. PMID: 28564595.
    View in: PubMed
  4. Zimmerman B, Kelly B, McMillan BJ, Seegar TCM, Dror RO, Kruse AC, Blacklow SC. Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Cell. 2016 11 03; 167(4):1041-1051.e11. PMID: 27881302.
    View in: PubMed
  5. Seegar WS, Yates MA, Doney GE, Jenny JP, Seegar TC, Perkins C, Giovanni M. Migrating Tundra Peregrine Falcons accumulate polycyclic aromatic hydrocarbons along Gulf of Mexico following Deepwater Horizon oil spill. Ecotoxicology. 2015 Jul; 24(5):1102-11. PMID: 25794559.
    View in: PubMed
  6. Barton WA, Dalton AC, Seegar TC, Himanen JP, Nikolov DB. Tie2 and Eph receptor tyrosine kinase activation and signaling. Cold Spring Harb Perspect Biol. 2014 Mar 01; 6(3). PMID: 24478383; PMCID: PMC3949358.
  7. Yu X, Seegar TC, Dalton AC, Tzvetkova-Robev D, Goldgur Y, Rajashankar KR, Nikolov DB, Barton WA. Structural basis for angiopoietin-1-mediated signaling initiation. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):7205-10. PMID: 23592718; PMCID: PMC3645508.
  8. Seegar T, Barton W. Imaging protein-protein interactions in vivo. J Vis Exp. 2010 Oct 10; (44). PMID: 20972411; PMCID: PMC3185630.
  9. Seegar TC, Eller B, Tzvetkova-Robev D, Kolev MV, Henderson SC, Nikolov DB, Barton WA. Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands. Mol Cell. 2010 Mar 12; 37(5):643-55. PMID: 20227369; PMCID: PMC2841065.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at For faculty personal and demographic information, contact HMS Office for Faculty Affairs at
Seegar's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
Co-Authors Expand Description
Similar People Expand Description
Same Department Expand Description