Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Robin Reed, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35GM122524 (REED, ROBIN E.) Apr 1, 2017 - Mar 31, 2022
    RNA Processing Machines in Biology and Disease
    Role: Principal Investigator
  2. R01GM059123 (REED, ROBIN E) Jan 1, 2000 - Dec 31, 2003
    Role: Principal Investigator
  3. R01GM043375 (REED, ROBIN E.) Jul 1, 1990 - Jul 31, 2017
    Functional Coupling of Steps in Genes Expression
    Role: Principal Investigator
  4. R56GM043375 (REED, ROBIN E) Jul 1, 1990 - Feb 29, 2008
    Functional Coupling of Steps in Genes Expression
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wang K, Yin C, Du X, Chen S, Wang J, Zhang L, Wang L, Yu Y, Chi B, Shi M, Wang C, Reed R, Zhou Y, Huang J, Cheng H. A U2-snRNP-independent role of SF3b in promoting mRNA export. Proc Natl Acad Sci U S A. 2019 04 16; 116(16):7837-7846. PMID: 30923118.
    Citations: 6     Fields:    Translation:HumansCells
  2. Yin S, Gambe RG, Sun J, Martinez AZ, Cartun ZJ, Regis FFD, Wan Y, Fan J, Brooks AN, Herman SEM, Ten Hacken E, Taylor-Weiner A, Rassenti LZ, Ghia EM, Kipps TJ, Obeng EA, Cibulskis CL, Neuberg D, Campagna DR, Fleming MD, Ebert BL, Wiestner A, Leshchiner I, DeCaprio JA, Getz G, Reed R, Carrasco RD, Wu CJ, Wang L. A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion. Cancer Cell. 2019 02 11; 35(2):283-296.e5. PMID: 30712845.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  3. Chi B, O'Connell JD, Iocolano AD, Coady JA, Yu Y, Gangopadhyay J, Gygi SP, Reed R. The neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex. Nucleic Acids Res. 2018 12 14; 46(22):11939-11951. PMID: 30398641.
    Citations: 12     Fields:    Translation:HumansCells
  4. Ten Hacken E, Valentin R, Regis FFD, Sun J, Yin S, Werner L, Deng J, Gruber M, Wong J, Zheng M, Gill AL, Seiler M, Smith P, Thomas M, Buonamici S, Ghia EM, Kim E, Rassenti LZ, Burger JA, Kipps TJ, Meyerson ML, Bachireddy P, Wang L, Reed R, Neuberg D, Carrasco RD, Brooks AN, Letai A, Davids MS, Wu CJ. Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies. JCI Insight. 2018 10 04; 3(19). PMID: 30282833.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  5. Chi B, O'Connell JD, Yamazaki T, Gangopadhyay J, Gygi SP, Reed R. Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins. Sci Rep. 2018 06 08; 8(1):8755. PMID: 29884807.
    Citations: 16     Fields:    Translation:HumansCells
  6. Yin S, Iocolano A, Yu Y, Gangopadhyay J, Reed R. In Vitro System for Coupling RNAP II Transcription to Primary microRNA Processing and a Three-Way System for RNAP II Transcription/Splicing/microRNA Processing. Methods Mol Biol. 2018; 1823:43-50. PMID: 29959672.
    Citations:    Fields:    Translation:HumansCells
  7. Yin S, Lopez-Gonzalez R, Kunz RC, Gangopadhyay J, Borufka C, Gygi SP, Gao FB, Reed R. Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients. Cell Rep. 2017 06 13; 19(11):2244-2256. PMID: 28614712.
    Citations: 37     Fields:    Translation:HumansCells
  8. Paolella BR, Gibson WJ, Urbanski LM, Alberta JA, Zack TI, Bandopadhayay P, Nichols CA, Agarwalla PK, Brown MS, Lamothe R, Yu Y, Choi PS, Obeng EA, Heckl D, Wei G, Wang B, Tsherniak A, Vazquez F, Weir BA, Root DE, Cowley GS, Buhrlage SJ, Stiles CD, Ebert BL, Hahn WC, Reed R, Beroukhim R. Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. Elife. 2017 02 08; 6. PMID: 28177281.
    Citations: 32     Fields:    Translation:HumansCells
  9. Wang L, Brooks AN, Fan J, Wan Y, Gambe R, Li S, Hergert S, Yin S, Freeman SS, Levin JZ, Fan L, Seiler M, Buonamici S, Smith PG, Chau KF, Cibulskis CL, Zhang W, Rassenti LZ, Ghia EM, Kipps TJ, Fernandes S, Bloch DB, Kotliar D, Landau DA, Shukla SA, Aster JC, Reed R, DeLuca DS, Brown JR, Neuberg D, Getz G, Livak KJ, Meyerson MM, Kharchenko PV, Wu CJ. Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia. Cancer Cell. 2016 Nov 14; 30(5):750-763. PMID: 27818134.
    Citations: 65     Fields:    Translation:HumansCells
  10. Yin S, Yu Y, Reed R. Primary microRNA processing is functionally coupled to RNAP II transcription in vitro. Sci Rep. 2015 Jul 07; 5:11992. PMID: 26149087.
    Citations: 9     Fields:    Translation:HumansCells
  11. Yu Y, Reed R. FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28):8608-13. PMID: 26124092.
    Citations: 36     Fields:    Translation:HumansCells
  12. Shi M, Zhang H, Wang L, Zhu C, Sheng K, Du Y, Wang K, Dias A, Chen S, Whitman M, Wang E, Reed R, Cheng H. Premature Termination Codons Are Recognized in the Nucleus in A Reading-Frame Dependent Manner. Cell Discov. 2015; 1. PMID: 26491543.
    Citations: 9     
  13. Yu Y, Chi B, Xia W, Gangopadhyay J, Yamazaki T, Winkelbauer-Hurt ME, Yin S, Eliasse Y, Adams E, Shaw CE, Reed R. U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafish. Nucleic Acids Res. 2015 Mar 31; 43(6):3208-18. PMID: 25735748.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  14. Folco EG, Reed R. In vitro systems for coupling RNAP II transcription to splicing and polyadenylation. Methods Mol Biol. 2014; 1126:169-77. PMID: 24549664.
    Citations: 4     Fields:    Translation:HumansCells
  15. Chesi A, Staahl BT, Jovicic A, Couthouis J, Fasolino M, Raphael AR, Yamazaki T, Elias L, Polak M, Kelly C, Williams KL, Fifita JA, Maragakis NJ, Nicholson GA, King OD, Reed R, Crabtree GR, Blair IP, Glass JD, Gitler AD. Exome sequencing to identify de novo mutations in sporadic ALS trios. Nat Neurosci. 2013 Jul; 16(7):851-5. PMID: 23708140.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  16. Lei H, Zhai B, Yin S, Gygi S, Reed R. Evidence that a consensus element found in naturally intronless mRNAs promotes mRNA export. Nucleic Acids Res. 2013 Feb 01; 41(4):2517-25. PMID: 23275560.
    Citations: 43     Fields:    Translation:HumansCells
  17. Yamazaki T, Chen S, Yu Y, Yan B, Haertlein TC, Carrasco MA, Tapia JC, Zhai B, Das R, Lalancette-Hebert M, Sharma A, Chandran S, Sullivan G, Nishimura AL, Shaw CE, Gygi SP, Shneider NA, Maniatis T, Reed R. FUS-SMN protein interactions link the motor neuron diseases ALS and SMA. Cell Rep. 2012 Oct 25; 2(4):799-806. PMID: 23022481.
    Citations: 115     Fields:    Translation:HumansCells
  18. Folco EG, Lee CS, Dufu K, Yamazaki T, Reed R. The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. PLoS One. 2012; 7(8):e43804. PMID: 22928037.
    Citations: 14     Fields:    Translation:HumansCells
  19. Folco EG, Lei H, Hsu JL, Reed R. Small-scale nuclear extracts for functional assays of gene-expression machineries. J Vis Exp. 2012 Jun 27; (64). PMID: 22782264.
    Citations: 15     Fields:    Translation:HumansCells
  20. Viphakone N, Hautbergue GM, Walsh M, Chang CT, Holland A, Folco EG, Reed R, Wilson SA. TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export. Nat Commun. 2012; 3:1006. PMID: 22893130.
    Citations: 80     Fields:    Translation:HumansCells
  21. Wang L, Lawrence MS, Wan Y, Stojanov P, Sougnez C, Stevenson K, Werner L, Sivachenko A, DeLuca DS, Zhang L, Zhang W, Vartanov AR, Fernandes SM, Goldstein NR, Folco EG, Cibulskis K, Tesar B, Sievers QL, Shefler E, Gabriel S, Hacohen N, Reed R, Meyerson M, Golub TR, Lander ES, Neuberg D, Brown JR, Getz G, Wu CJ. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med. 2011 Dec 29; 365(26):2497-506. PMID: 22150006.
    Citations: 461     Fields:    Translation:HumansCells
  22. Lei H, Dias AP, Reed R. Export and stability of naturally intronless mRNAs require specific coding region sequences and the TREX mRNA export complex. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):17985-90. PMID: 22010220.
    Citations: 51     Fields:    Translation:Cells
  23. Folco EG, Coil KE, Reed R. The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region. Genes Dev. 2011 Mar 01; 25(5):440-4. PMID: 21363962.
    Citations: 76     Fields:    Translation:HumansCells
  24. Dias AP, Dufu K, Lei H, Reed R. A role for TREX components in the release of spliced mRNA from nuclear speckle domains. Nat Commun. 2010 Oct 19; 1:97. PMID: 20981025.
    Citations: 73     Fields:    Translation:HumansCells
  25. Dufu K, Livingstone MJ, Seebacher J, Gygi SP, Wilson SA, Reed R. ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex. Genes Dev. 2010 Sep 15; 24(18):2043-53. PMID: 20844015.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  26. Yu Y, Das R, Folco EG, Reed R. A model in vitro system for co-transcriptional splicing. Nucleic Acids Res. 2010 Nov; 38(21):7570-8. PMID: 20631007.
    Citations: 8     Fields:    Translation:Cells
  27. Lee CS, Dias AP, Jedrychowski M, Patel AH, Hsu JL, Reed R. Human DDX3 functions in translation and interacts with the translation initiation factor eIF3. Nucleic Acids Res. 2008 Aug; 36(14):4708-18. PMID: 18628297.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  28. Valencia P, Dias AP, Reed R. Splicing promotes rapid and efficient mRNA export in mammalian cells. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3386-91. PMID: 18287003.
    Citations: 110     Fields:    Translation:HumansAnimalsCells
  29. Das R, Yu J, Zhang Z, Gygi MP, Krainer AR, Gygi SP, Reed R. SR proteins function in coupling RNAP II transcription to pre-mRNA splicing. Mol Cell. 2007 Jun 22; 26(6):867-81. PMID: 17588520.
    Citations: 163     Fields:    Translation:HumansAnimalsCells
  30. Ganapathi KA, Austin KM, Lee CS, Dias A, Malsch MM, Reed R, Shimamura A. The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA. Blood. 2007 Sep 01; 110(5):1458-65. PMID: 17475909.
    Citations: 58     Fields:    Translation:HumansCellsCTClinical Trials
  31. Hims MM, Ibrahim EC, Leyne M, Mull J, Liu L, Lazaro C, Shetty RS, Gill S, Gusella JF, Reed R, Slaugenhaupt SA. Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia. J Mol Med (Berl). 2007 Feb; 85(2):149-61. PMID: 17206408.
    Citations: 29     Fields:    Translation:HumansCells
  32. Ibrahim EC, Hims MM, Shomron N, Burge CB, Slaugenhaupt SA, Reed R. Weak definition of IKBKAP exon 20 leads to aberrant splicing in familial dysautonomia. Hum Mutat. 2007 Jan; 28(1):41-53. PMID: 16964593.
    Citations: 23     Fields:    Translation:HumansCells
  33. Cheng H, Dufu K, Lee CS, Hsu JL, Dias A, Reed R. Human mRNA export machinery recruited to the 5' end of mRNA. Cell. 2006 Dec 29; 127(7):1389-400. PMID: 17190602.
    Citations: 216     Fields:    Translation:HumansCells
  34. Das R, Dufu K, Romney B, Feldt M, Elenko M, Reed R. Functional coupling of RNAP II transcription to spliceosome assembly. Genes Dev. 2006 May 01; 20(9):1100-9. PMID: 16651655.
    Citations: 57     Fields:    Translation:HumansCells
  35. Masuda S, Das R, Cheng H, Hurt E, Dorman N, Reed R. Recruitment of the human TREX complex to mRNA during splicing. Genes Dev. 2005 Jul 01; 19(13):1512-7. PMID: 15998806.
    Citations: 196     Fields:    Translation:HumansCells
  36. Reed R, Cheng H. TREX, SR proteins and export of mRNA. Curr Opin Cell Biol. 2005 Jun; 17(3):269-73. PMID: 15901496.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  37. Ibrahim EC, Schaal TD, Hertel KJ, Reed R, Maniatis T. Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5002-7. PMID: 15753297.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  38. Ferraiuolo MA, Lee CS, Ler LW, Hsu JL, Costa-Mattioli M, Luo MJ, Reed R, Sonenberg N. A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4118-23. PMID: 15024115.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  39. Hurt E, Luo MJ, Röther S, Reed R, Strässer K. Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):1858-62. PMID: 14769921.
    Citations: 65     Fields:    Translation:AnimalsCells
  40. Rodríguez-Navarro S, Fischer T, Luo MJ, Antúnez O, Brettschneider S, Lechner J, Pérez-Ortín JE, Reed R, Hurt E. Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery. Cell. 2004 Jan 09; 116(1):75-86. PMID: 14718168.
    Citations: 169     Fields:    Translation:AnimalsCells
  41. Zhou Z, Reed R. Purification of functional RNA-protein complexes using MS2-MBP. Curr Protoc Mol Biol. 2003 Aug; Chapter 27:Unit 27.3. PMID: 18265330.
    Citations: 22     Fields:    Translation:HumansCells
  42. Luo MJ, Reed R. Identification of RNA binding proteins by UV cross-linking. Curr Protoc Mol Biol. 2003 Aug; Chapter 27:Unit 27.2. PMID: 18265329.
    Citations: 5     Fields:    Translation:HumansCells
  43. Lee CS, Das R, Reed R. Agarose gel separation/isolation of RNA-protein complexes. Curr Protoc Mol Biol. 2003 Aug; Chapter 27:Unit 27.1. PMID: 18265328.
    Citations: 1     Fields:    Translation:HumansCells
  44. Reed R. Coupling transcription, splicing and mRNA export. Curr Opin Cell Biol. 2003 Jun; 15(3):326-31. PMID: 12787775.
    Citations: 112     Fields:    Translation:HumansCells
  45. Zhou Z, Licklider LJ, Gygi SP, Reed R. Comprehensive proteomic analysis of the human spliceosome. Nature. 2002 Sep 12; 419(6903):182-5. PMID: 12226669.
    Citations: 370     Fields:    Translation:HumansCells
  46. Zhou Z, Sim J, Griffith J, Reed R. Purification and electron microscopic visualization of functional human spliceosomes. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12203-7. PMID: 12215496.
    Citations: 37     Fields:    Translation:HumansCells
  47. Chung S, Zhou Z, Huddleston KA, Harrison DA, Reed R, Coleman TA, Rymond BC. Crooked neck is a component of the human spliceosome and implicated in the splicing process. Biochim Biophys Acta. 2002 Jul 19; 1576(3):287-97. PMID: 12084575.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  48. Strässer K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondón AG, Aguilera A, Struhl K, Reed R, Hurt E. TREX is a conserved complex coupling transcription with messenger RNA export. Nature. 2002 May 16; 417(6886):304-8. PMID: 11979277.
    Citations: 377     Fields:    Translation:HumansAnimalsCells
  49. Maniatis T, Reed R. An extensive network of coupling among gene expression machines. Nature. 2002 Apr 04; 416(6880):499-506. PMID: 11932736.
    Citations: 446     Fields:    Translation:Cells
  50. Reed R, Hurt E. A conserved mRNA export machinery coupled to pre-mRNA splicing. Cell. 2002 Feb 22; 108(4):523-31. PMID: 11909523.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  51. Luo ML, Zhou Z, Magni K, Christoforides C, Rappsilber J, Mann M, Reed R. Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature. 2001 Oct 11; 413(6856):644-7. PMID: 11675789.
    Citations: 165     Fields:    Translation:HumansAnimalsCells
  52. Reed R, Magni K. A new view of mRNA export: separating the wheat from the chaff. Nat Cell Biol. 2001 Sep; 3(9):E201-4. PMID: 11533670.
    Citations: 33     Fields:    Translation:AnimalsCells
  53. Chua K, Reed R. An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing. Mol Cell Biol. 2001 Mar; 21(5):1509-14. PMID: 11238888.
    Citations: 46     Fields:    Translation:Cells
  54. Clouse KN, Luo MJ, Zhou Z, Reed R. A Ran-independent pathway for export of spliced mRNA. Nat Cell Biol. 2001 Jan; 3(1):97-9. PMID: 11146633.
    Citations: 28     Fields:    Translation:AnimalsCells
  55. Zhou Z, Luo MJ, Straesser K, Katahira J, Hurt E, Reed R. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature. 2000 Sep 21; 407(6802):401-5. PMID: 11014198.
    Citations: 223     Fields:    Translation:HumansAnimalsCells
  56. DeGiorgio CM, Schachter SC, Handforth A, Salinsky M, Thompson J, Uthman B, Reed R, Collins S, Tecoma E, Morris GL, Vaughn B, Naritoku DK, Henry T, Labar D, Gilmartin R, Labiner D, Osorio I, Ristanovic R, Jones J, Murphy J, Ney G, Wheless J, Lewis P, Heck C. Prospective long-term study of vagus nerve stimulation for the treatment of refractory seizures. Epilepsia. 2000 Sep; 41(9):1195-200. PMID: 10999559.
    Citations: 92     Fields:    Translation:HumansCTClinical Trials
  57. Reed R. Mechanisms of fidelity in pre-mRNA splicing. Curr Opin Cell Biol. 2000 Jun; 12(3):340-5. PMID: 10801464.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  58. Das R, Zhou Z, Reed R. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. Mol Cell. 2000 May; 5(5):779-87. PMID: 10882114.
    Citations: 79     Fields:    Translation:Cells
  59. Luo MJ, Reed R. Splicing is required for rapid and efficient mRNA export in metazoans. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14937-42. PMID: 10611316.
    Citations: 149     Fields:    Translation:HumansAnimalsCells
  60. Chua K, Reed R. The RNA splicing factor hSlu7 is required for correct 3' splice-site choice. Nature. 1999 Nov 11; 402(6758):207-10. PMID: 10647016.
    Citations: 42     Fields:    Translation:HumansCells
  61. Das R, Reed R. Resolution of the mammalian E complex and the ATP-dependent spliceosomal complexes on native agarose mini-gels. RNA. 1999 Nov; 5(11):1504-8. PMID: 10580479.
    Citations: 70     Fields:    Translation:AnimalsCells
  62. Das BK, Xia L, Palandjian L, Gozani O, Chyung Y, Reed R. Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155. Mol Cell Biol. 1999 Oct; 19(10):6796-802. PMID: 10490618.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  63. Will CL, Schneider C, Reed R, Lührmann R. Identification of both shared and distinct proteins in the major and minor spliceosomes. Science. 1999 Jun 18; 284(5422):2003-5. PMID: 10373121.
    Citations: 69     Fields:    Translation:HumansCells
  64. Reed R, Chiara MD. Identification of RNA-protein contacts within functional ribonucleoprotein complexes by RNA site-specific labeling and UV crosslinking. Methods. 1999 May; 18(1):3-12. PMID: 10208811.
    Citations: 8     Fields:    Translation:Cells
  65. Chua K, Reed R. Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing. Genes Dev. 1999 Apr 01; 13(7):841-50. PMID: 10197984.
    Citations: 27     Fields:    Translation:HumansCells
  66. Bedford MT, Reed R, Leder P. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10602-7. PMID: 9724750.
    Citations: 52     Fields:    Translation:AnimalsCells
  67. Seghezzi W, Chua K, Shanahan F, Gozani O, Reed R, Lees E. Cyclin E associates with components of the pre-mRNA splicing machinery in mammalian cells. Mol Cell Biol. 1998 Aug; 18(8):4526-36. PMID: 9671462.
    Citations: 41     Fields:    Translation:HumansCells
  68. Gozani O, Potashkin J, Reed R. A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site. Mol Cell Biol. 1998 Aug; 18(8):4752-60. PMID: 9671485.
    Citations: 138     Fields:    Translation:AnimalsCells
  69. Wang C, Chua K, Seghezzi W, Lees E, Gozani O, Reed R. Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. Genes Dev. 1998 May 15; 12(10):1409-14. PMID: 9585501.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  70. Zhou Z, Reed R. Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing. EMBO J. 1998 Apr 01; 17(7):2095-106. PMID: 9524131.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  71. Chiara MD, Palandjian L, Feld Kramer R, Reed R. Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals. EMBO J. 1997 Aug 01; 16(15):4746-59. PMID: 9303319.
    Citations: 52     Fields:    Translation:AnimalsCells
  72. Berglund JA, Chua K, Abovich N, Reed R, Rosbash M. The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC. Cell. 1997 May 30; 89(5):781-7. PMID: 9182766.
    Citations: 166     Fields:    Translation:AnimalsCells
  73. Hong W, Bennett M, Xiao Y, Feld Kramer R, Wang C, Reed R. Association of U2 snRNP with the spliceosomal complex E. Nucleic Acids Res. 1997 Jan 15; 25(2):354-61. PMID: 9016565.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  74. Chiara MD, Gozani O, Bennett M, Champion-Arnaud P, Palandjian L, Reed R. Identification of proteins that interact with exon sequences, splice sites, and the branchpoint sequence during each stage of spliceosome assembly. Mol Cell Biol. 1996 Jul; 16(7):3317-26. PMID: 8668147.
    Citations: 58     Fields:    Translation:AnimalsCells
  75. Reed R. Initial splice-site recognition and pairing during pre-mRNA splicing. Curr Opin Genet Dev. 1996 Apr; 6(2):215-20. PMID: 8722179.
    Citations: 121     Fields:    Translation:AnimalsCells
  76. Gozani O, Feld R, Reed R. Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A. Genes Dev. 1996 Jan 15; 10(2):233-43. PMID: 8566756.
    Citations: 113     Fields:    Translation:HumansCells
  77. Staknis D, Reed R. Members of a family of proteins (the RD family) detected by a U1 70K monoclonal antibody are present in spliceosomal complexes. Nucleic Acids Res. 1995 Oct 25; 23(20):4081-6. PMID: 7479068.
    Citations: 10     Fields:    Translation:HumansCells
  78. Champion-Arnaud P, Gozani O, Palandjian L, Reed R. Accumulation of a novel spliceosomal complex on pre-mRNAs containing branch site mutations. Mol Cell Biol. 1995 Oct; 15(10):5750-6. PMID: 7565727.
    Citations: 19     Fields:    Translation:Cells
  79. Chiara MD, Reed R. A two-step mechanism for 5' and 3' splice-site pairing. Nature. 1995 Jun 08; 375(6531):510-3. PMID: 7777062.
    Citations: 47     Fields:    Translation:AnimalsCells
  80. Staknis D, Reed R. SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex. Mol Cell Biol. 1994 Nov; 14(11):7670-82. PMID: 7935481.
    Citations: 152     Fields:    Translation:HumansCells
  81. Champion-Arnaud P, Reed R. The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. Genes Dev. 1994 Aug 15; 8(16):1974-83. PMID: 7958871.
    Citations: 47     Fields:    Translation:HumansCells
  82. Gozani O, Patton JG, Reed R. A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction. EMBO J. 1994 Jul 15; 13(14):3356-67. PMID: 8045264.
    Citations: 106     Fields:    Translation:Cells
  83. Chiara MD, Champion-Arnaud P, Buvoli M, Nadal-Ginard B, Reed R. Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114. Proc Natl Acad Sci U S A. 1994 Jul 05; 91(14):6403-7. PMID: 8022796.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  84. Staknis D, Reed R. Direct interactions between pre-mRNA and six U2 small nuclear ribonucleoproteins during spliceosome assembly. Mol Cell Biol. 1994 May; 14(5):2994-3005. PMID: 8164655.
    Citations: 58     Fields:    Translation:AnimalsCells
  85. Bennett M, Reed R. Correspondence between a mammalian spliceosome component and an essential yeast splicing factor. Science. 1993 Oct 01; 262(5130):105-8. PMID: 8211113.
    Citations: 39     Fields:    Translation:HumansCells
  86. Michaud S, Reed R. A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammals. Genes Dev. 1993 Jun; 7(6):1008-20. PMID: 8504926.
    Citations: 90     Fields:    Translation:AnimalsCells
  87. Bennett M, Michaud S, Kingston J, Reed R. Protein components specifically associated with prespliceosome and spliceosome complexes. Genes Dev. 1992 Oct; 6(10):1986-2000. PMID: 1398075.
    Citations: 97     Fields:    Translation:AnimalsCells
  88. Bennett M, Piñol-Roma S, Staknis D, Dreyfuss G, Reed R. Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro. Mol Cell Biol. 1992 Jul; 12(7):3165-75. PMID: 1620124.
    Citations: 64     Fields:    Translation:AnimalsCells
  89. Michaud S, Reed R. An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway. Genes Dev. 1991 Dec; 5(12B):2534-46. PMID: 1836445.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  90. Reed R. Protein composition of mammalian spliceosomes assembled in vitro. Proc Natl Acad Sci U S A. 1990 Oct; 87(20):8031-5. PMID: 2146679.
    Citations: 50     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Reed's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (308)
Co-Authors (38)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.