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Konrad H. Stopsack, M.D.

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Biography
University of Freiburg, Freiburg, GermanyMD2013Medicine
Harvard School of Public Health, Boston, MAMPH2014Biostatistics and Epidemiology
Mayo Clinic, Rochester, MNResidency, Board certification2017Internal Medicine
Memorial Sloan Kettering Cancer Center, New York, NYPostdoctoral training2021Cancer Epidemiology

Overview
I am a molecular and clinical epidemiologist with a focus on cancer epidemiology and a background as a board-certified internal medicine physician. My main research interest is how potentially modifiable exposures cause solid tumors through genomic heterogeneity and influence cancer progression. I am passionate about combining well-defined observational studies and state-of-the-art genomics in order to guide cancer prevention and treatment. My methodologic and teaching interests include application and further development of epidemiologic methods for high-dimensional biomarker studies and clinical studies.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 17YOUN16 (Stopsack)
    Prostate Cancer Foundation
    Young Investigator Award: Intratumoral cholesterol metabolism to guide prostate cancer therapy
    Role: PI
  2. Challenge Award (Kantoff)
    Prostate Cancer Foundation
    Clonal hematopoiesis in prostate cancer
    Role: Co-Investigator
  3. Traditional Bridge Grant (Amon/Mucci)
    Harvard–MIT Bridge Program
    Credentialing aneuploidy as a prognostic biomarker in prostate cancer
    Role: Co-Investigator
  4. W81XWH-18-1-0330 (Stopsack)
    Department of Defense, Congressionally Directed Medical Research Program
    Early-Investigator Research Award: Cholesterol synthesis and statin therapy in prostate cancer
    Role: PI

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vaselkiv JB, Ceraolo C, Wilson KM, Pernar CH, Rencsok EM, Stopsack KH, Grob ST, Plym A, Giovannucci EL, Olumi AF, Kibel AS, Preston MA, Mucci LA. 5-alpha reductase inhibitors and prostate cancer mortality among men with regular access to screening and health care. Cancer Epidemiol Biomarkers Prev. 2022 Mar 04. PMID: 35255119.
    Citations:    Fields:    
  2. Ozcan Z, Lucas FAS, Wong JW, Chang K, Stopsack KH, Fowler J, Jakubek YA, Scheet P. Chromosomal imbalances detected via RNA-sequencing in 28 cancers. Bioinformatics. 2022 Jan 06. PMID: 34999743.
    Citations:    Fields:    
  3. Stopsack KH, Salles DC, Vaselkiv JB, Grob ST, Mucci LA, Lotan TL. p53 Immunohistochemistry to Identify Very High-risk Primary Prostate Cancer: A Prospective Cohort Study with Three Decades of Follow-up. Eur Urol Oncol. 2021 Dec 27. PMID: 34969655.
    Citations:    Fields:    
  4. Stopsack KH, Tyekucheva S, Wang M, Gerke TA, Vaselkiv JB, Penney KL, Kantoff PW, Finn SP, Fiorentino M, Loda M, Lotan TL, Parmigiani G, Mucci LA. Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays. Elife. 2021 12 23; 10. PMID: 34939926.
    Citations:    Fields:    Translation:Humans
  5. Stopsack KH, Nandakumar S, Arora K, Nguyen B, Vasselman SE, Nweji B, McBride SM, Morris MJ, Rathkopf DE, Slovin SF, Danila DC, Autio KA, Scher HI, Mucci LA, Solit DB, Gönen M, Chen Y, Berger MF, Schultz N, Abida W, Kantoff PW. Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors. Clin Cancer Res. 2022 01 15; 28(2):318-326. PMID: 34667026.
    Citations:    Fields:    Translation:Humans
  6. Hurwitz LM, Agalliu I, Albanes D, Barry KH, Berndt SI, Cai Q, Chen C, Cheng I, Genkinger JM, Giles GG, Huang J, Joshu CE, Key TJ, Knutsen S, Koutros S, Langseth H, Li SX, MacInnis RJ, Markt SC, Penney KL, Perez-Cornago A, Rohan TE, Smith-Warner SA, Stampfer MJ, Stopsack KH, Tangen CM, Travis RC, Weinstein SJ, Lang PhD W, Jacobs EJ, Mucci LA, Platz EA, Cook MB. Recommended Definitions of Aggressive Prostate Cancer for Etiologic Epidemiologic Research. J Natl Cancer Inst. 2021 06 01; 113(6):727-734. PMID: 33010161.
    Citations: 8     Fields:    Translation:Humans
  7. Drago JZ, Gönen M, Thanarajasingam G, Sacks CA, Morris MJ, Kantoff PW, Stopsack KH. Inferences About Drug Safety in Phase III Trials in Oncology: Examples From Advanced Prostate Cancer. J Natl Cancer Inst. 2021 05 04; 113(5):553-561. PMID: 32857839.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  8. Allott EH, Craig EL, Stopsack KH. In search of the optimal setting for statin trials in prostate cancer: the power of population-based studies. Prostate Cancer Prostatic Dis. 2021 09; 24(3):583-584. PMID: 33782544.
    Citations: 1     Fields:    Translation:Humans
  9. Stopsack KH. Editorial Comment. J Urol. 2021 05; 205(5):1378. PMID: 33728931.
    Citations:    Fields:    
  10. Stopsack KH. Statins and Prostate Cancer: Bias, Precision Medicine, or Population Health? Eur Urol. 2021 04; 79(4):453-455. PMID: 33551298.
    Citations:    Fields:    Translation:Humans
  11. Pan W, Zhang Z, Kimball H, Qu F, Berlind K, Stopsack KH, Lee GM, Choueiri TK, Kantoff PW. Abiraterone Acetate Induces CREB1 Phosphorylation and Enhances the Function of the CBP-p300 Complex, Leading to Resistance in Prostate Cancer Cells. Clin Cancer Res. 2021 04 01; 27(7):2087-2099. PMID: 33495313.
    Citations: 4     Fields:    Translation:HumansCells
  12. Stopsack KH. Reply to Johann S. de Bono, Maha Hussain, and Jinyu Kang's Letter to the Editor re: Konrad H. Stopsack. Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.09.024. Eur Urol. 2021 03; 79(3):e81-e82. PMID: 33358233.
    Citations:    Fields:    Translation:HumansCells
  13. Chakraborty G, Patail NK, Hirani R, Nandakumar S, Mazzu YZ, Yoshikawa Y, Atiq M, Jehane LE, Stopsack KH, Lee GM, Abida W, Morris MJ, Mucci LA, Danila D, Kantoff PW. Attenuation of SRC Kinase Activity Augments PARP Inhibitor-mediated Synthetic Lethality in BRCA2-altered Prostate Tumors. Clin Cancer Res. 2021 03 15; 27(6):1792-1806. PMID: 33334906.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  14. Bolton KL, Ptashkin RN, Gao T, Braunstein L, Devlin SM, Kelly D, Patel M, Berthon A, Syed A, Yabe M, Coombs CC, Caltabellotta NM, Walsh M, Offit K, Stadler Z, Mandelker D, Schulman J, Patel A, Philip J, Bernard E, Gundem G, Ossa JEA, Levine M, Martinez JSM, Farnoud N, Glodzik D, Li S, Robson ME, Lee C, Pharoah PDP, Stopsack KH, Spitzer B, Mantha S, Fagin J, Boucai L, Gibson CJ, Ebert BL, Young AL, Druley T, Takahashi K, Gillis N, Ball M, Padron E, Hyman DM, Baselga J, Norton L, Gardos S, Klimek VM, Scher H, Bajorin D, Paraiso E, Benayed R, Arcila ME, Ladanyi M, Solit DB, Berger MF, Tallman M, Garcia-Closas M, Chatterjee N, Diaz LA, Levine RL, Morton LM, Zehir A, Papaemmanuil E. Cancer therapy shapes the fitness landscape of clonal hematopoiesis. Nat Genet. 2020 11; 52(11):1219-1226. PMID: 33106634.
    Citations: 46     Fields:    Translation:Humans
  15. Stopsack KH. Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib. Eur Urol. 2021 04; 79(4):442-445. PMID: 33012578.
    Citations: 7     Fields:    Translation:HumansCells
  16. Stopsack KH, Huang Y, Tyekucheva S, Gerke TA, Bango C, Elfandy H, Bowden M, Penney KL, Roberts TM, Parmigiani G, Kantoff PW, Mucci LA, Loda M. Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tumor Tissue to Identify Single-Cell-Level PI3K Pathway Activation. Clin Cancer Res. 2020 11 15; 26(22):5903-5913. PMID: 32913135.
    Citations: 3     Fields:    Translation:HumansCells
  17. Stopsack KH, Gerke T, Zareba P, Pettersson A, Chowdhury D, Ebot EM, Flavin R, Finn S, Kantoff PW, Stampfer MJ, Loda M, Fiorentino M, Mucci LA. Tumor protein expression of the DNA repair gene BRCA1 and lethal prostate cancer. Carcinogenesis. 2020 07 14; 41(7):904-908. PMID: 32556091.
    Citations:    Fields:    Translation:HumansCells
  18. Fankhauser CD, Penney KL, Gonzalez-Feliciano AG, Clarke NW, Hermanns T, Stopsack KH, Fiorentino M, Loda M, Mahal B, Gerke TA, Preston MA, Mucci LA. Inferior Cancer Survival for Men with Localized High-grade Prostate Cancer but Low Prostate-specific Antigen. Eur Urol. 2020 10; 78(4):637-639. PMID: 32624279.
    Citations: 1     Fields:    Translation:Humans
  19. Feng X, Song M, Preston MA, Ma W, Hu Y, Pernar CH, Stopsack KH, Ebot EM, Fu BC, Zhang Y, Li N, Dai M, Liu L, Giovannucci EL, Mucci LA. The association of diabetes with risk of prostate cancer defined by clinical and molecular features. Br J Cancer. 2020 08; 123(4):657-665. PMID: 32467600.
    Citations: 6     Fields:    Translation:Humans
  20. Nguyen B, Mota JM, Nandakumar S, Stopsack KH, Weg E, Rathkopf D, Morris MJ, Scher HI, Kantoff PW, Gopalan A, Zamarin D, Solit DB, Schultz N, Abida W. Pan-cancer Analysis of CDK12 Alterations Identifies a Subset of Prostate Cancers with Distinct Genomic and Clinical Characteristics. Eur Urol. 2020 11; 78(5):671-679. PMID: 32317181.
    Citations: 16     Fields:    Translation:Humans
  21. Mota JM, Barnett E, Nauseef JT, Nguyen B, Stopsack KH, Wibmer A, Flynn JR, Heller G, Danila DC, Rathkopf D, Slovin S, Kantoff PW, Scher HI, Morris MJ, Schultz N, Solit DB, Abida W. Platinum-Based Chemotherapy in Metastatic Prostate Cancer With DNA Repair Gene Alterations. JCO Precis Oncol. 2020; 4:355-366. PMID: 32856010.
    Citations: 20     Fields:    
  22. Stopsack KH, Mucci LA, Antonarakis ES, Nelson PS, Kantoff PW. TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention? Cancer Discov. 2020 06; 10(6):779-782. PMID: 32276929.
    Citations: 159     Fields:    Translation:HumansCellsPHPublic Health
  23. Stopsack KH, Nandakumar S, Wibmer AG, Haywood S, Weg ES, Barnett ES, Kim CJ, Carbone EA, Vasselman SE, Nguyen B, Hullings MA, Scher HI, Morris MJ, Solit DB, Schultz N, Kantoff PW, Abida W. Oncogenic Genomic Alterations, Clinical Phenotypes, and Outcomes in Metastatic Castration-Sensitive Prostate Cancer. Clin Cancer Res. 2020 07 01; 26(13):3230-3238. PMID: 32220891.
    Citations: 21     Fields:    Translation:Humans
  24. Chakraborty G, Armenia J, Mazzu YZ, Nandakumar S, Stopsack KH, Atiq MO, Komura K, Jehane L, Hirani R, Chadalavada K, Yoshikawa Y, Khan NA, Chen Y, Abida W, Mucci LA, Lee GM, Nanjangud GJ, Kantoff PW. Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression. Clin Cancer Res. 2020 04 15; 26(8):2047-2064. PMID: 31796516.
    Citations: 15     Fields:    Translation:Humans
  25. Allott EH, Ebot EM, Stopsack KH, Gonzalez-Feliciano AG, Markt SC, Wilson KM, Ahearn TU, Gerke TA, Downer MK, Rider JR, Freedland SJ, Lotan TL, Kantoff PW, Platz EA, Loda M, Stampfer MJ, Giovannucci E, Sweeney CJ, Finn SP, Mucci LA. Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer. Clin Cancer Res. 2020 03 01; 26(5):1086-1093. PMID: 31754047.
    Citations: 9     Fields:    Translation:Humans
  26. Stopsack KH, Cerhan JR. Cumulative Doses of Ionizing Radiation From Computed Tomography: A Population-Based Study. Mayo Clin Proc. 2019 10; 94(10):2011-2021. PMID: 31248696.
    Citations: 3     Fields:    Translation:Humans
  27. Stopsack KH, Whittaker CA, Gerke TA, Loda M, Kantoff PW, Mucci LA, Amon A. Aneuploidy drives lethal progression in prostate cancer. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11390-11395. PMID: 31085648.
    Citations: 24     Fields:    Translation:HumansCells
  28. Khan NA, Stopsack KH, Allott EH, Gerke T, Giovannucci EL, Mucci LA, Kantoff PW. Intratumoral Sterol-27-Hydroxylase (CYP27A1) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2019 06; 28(6):1052-1058. PMID: 30867220.
    Citations: 7     Fields:    Translation:HumansCells
  29. Stopsack KH, Gerke T, Tyekucheva S, Mazzu YZ, Lee GM, Chakraborty G, Abida W, Mucci LA, Kantoff PW. Low Expression of the Androgen-Induced Tumor Suppressor Gene PLZF and Lethal Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2019 04; 28(4):707-714. PMID: 30602500.
    Citations: 7     Fields:    Translation:HumansCells
  30. Elfandy H, Armenia J, Pederzoli F, Pullman E, Pertega-Gomes N, Schultz N, Viswanathan K, Vosoughi A, Blattner M, Stopsack KH, Zadra G, Penney KL, Mosquera JM, Tyekucheva S, Mucci LA, Barbieri C, Loda M. Genetic and Epigenetic Determinants of Aggressiveness in Cribriform Carcinoma of the Prostate. Mol Cancer Res. 2019 02; 17(2):446-456. PMID: 30333152.
    Citations: 13     Fields:    Translation:HumansAnimals
  31. Pernar CH, Ebot EM, Pettersson A, Graff RE, Giunchi F, Ahearn TU, Gonzalez-Feliciano AG, Markt SC, Wilson KM, Stopsack KH, Gazeeva E, Lis RT, Parmigiani G, Rimm EB, Finn SP, Giovannucci EL, Fiorentino M, Mucci LA. A Prospective Study of the Association between Physical Activity and Risk of Prostate Cancer Defined by Clinical Features and TMPRSS2:ERG. Eur Urol. 2019 07; 76(1):33-40. PMID: 30301696.
    Citations: 12     Fields:    Translation:Humans
  32. Xie W, Stopsack KH, Drouin SJ, Fu H, Pomerantz MM, Mucci LA, Lee GM, Kantoff PW. Association of genetic variation of the six gene prognostic model for castration-resistant prostate cancer with survival. Prostate. 2019 01; 79(1):73-80. PMID: 30141208.
    Citations: 3     Fields:    Translation:Humans
  33. Stopsack KH, Gonzalez-Feliciano AG, Peisch SF, Downer MK, Gage RA, Finn S, Lis RT, Graff RE, Pettersson A, Pernar CH, Loda M, Kantoff PW, Ahearn TU, Mucci LA. A Prospective Study of Aspirin Use and Prostate Cancer Risk by TMPRSS2:ERG Status. Cancer Epidemiol Biomarkers Prev. 2018 10; 27(10):1231-1233. PMID: 30108097.
    Citations: 1     Fields:    Translation:Humans
  34. Stopsack KH, Ebot EM, Downer MK, Gerke TA, Rider JR, Kantoff PW, Mucci LA. Regular aspirin use and gene expression profiles in prostate cancer patients. Cancer Causes Control. 2018 Aug; 29(8):775-784. PMID: 29915914.
    Citations:    Fields:    Translation:HumansCells
  35. Brauner A, Alvendal C, Chromek M, Stopsack KH, Ehrström S, Schröder JM, Bohm-Starke N. Psoriasin, a novel anti-Candida albicans adhesin. J Mol Med (Berl). 2018 06; 96(6):537-545. PMID: 29736603.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  36. Stopsack KH, Gerke TA, Andrén O, Andersson SO, Giovannucci EL, Mucci LA, Rider JR. Cholesterol uptake and regulation in high-grade and lethal prostate cancers. Carcinogenesis. 2017 08 01; 38(8):806-811. PMID: 28595267.
    Citations: 34     Fields:    Translation:Humans
  37. Bormann T, Stopsack KH, Mader I, Weiller C, Rijntjes M. A formal analysis of alexia in persistent aura and a comparison to acquired pure alexia. Neurocase. 2017 Feb; 23(1):60-64. PMID: 28376693.
    Citations:    Fields:    Translation:Humans
  38. Stopsack KH, Greenberg AJ, Mucci LA. Common medications and prostate cancer mortality: a review. World J Urol. 2017 Jun; 35(6):875-882. PMID: 27492013.
    Citations: 7     Fields:    Translation:Humans
  39. Weidler S, Stopsack KH, Hammermann J, Sommerburg O, Mall MA, Hoffmann GF, Kohlmüller D, Okun JG, Macek M, Votava F, Krulišová V, Balašcaková M, Skalická V, Lee-Kirsch MA, Stopsack M. A product of immunoreactive trypsinogen and pancreatitis-associated protein as second-tier strategy in cystic fibrosis newborn screening. J Cyst Fibros. 2016 11; 15(6):752-758. PMID: 27461140.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  40. Stopsack KH, Gerke TA, Sinnott JA, Penney KL, Tyekucheva S, Sesso HD, Andersson SO, Andrén O, Cerhan JR, Giovannucci EL, Mucci LA, Rider JR. Cholesterol Metabolism and Prostate Cancer Lethality. Cancer Res. 2016 08 15; 76(16):4785-90. PMID: 27325648.
    Citations: 26     Fields:    Translation:Humans
  41. Kekre N, Mak KS, Stopsack KH, Binder M, Ishii K, Brånvall E, Cutler CS. Impact of HLA-Mismatch in Unrelated Donor Hematopoietic Stem Cell Transplantation: A Meta-Analysis. Am J Hematol. 2016 06; 91(6):551-5. PMID: 26927727.
    Citations: 7     Fields:    Translation:Humans
  42. Stopsack KH, Vinod Shah M. Bilateral Foot Gangrene. JAMA Oncol. 2016 Mar; 2(3):387-8. PMID: 26847423.
    Citations:    Fields:    Translation:Humans
  43. Stopsack KH, Ziehr DR, Rider JR, Giovannucci EL. Metformin and prostate cancer mortality: a meta-analysis. Cancer Causes Control. 2016 Jan; 27(1):105-13. PMID: 26537119.
    Citations: 27     Fields:    Translation:Humans
  44. Ramos NL, Dzung DT, Stopsack K, Jankó V, Pourshafie MR, Katouli M, Brauner A. Characterisation of uropathogenic Escherichia coli from children with urinary tract infection in different countries. Eur J Clin Microbiol Infect Dis. 2011 Dec; 30(12):1587-93. PMID: 21509475.
    Citations: 10     Fields:    Translation:HumansCells
  45. Vogelberg C, Stensvold CR, Monecke S, Ditzen A, Stopsack K, Heinrich-Gräfe U, Pöhlmann C. Blastocystis sp. subtype 2 detection during recurrence of gastrointestinal and urticarial symptoms. Parasitol Int. 2010 Sep; 59(3):469-71. PMID: 20363362.
    Citations: 35     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.