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Zhiyun Wei, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zeng A, Wei Z, Yan W, Yin J, Huang X, Zhou X, Li R, Shen F, Wu W, Wang X, You Y. Exosomal transfer of miR-151a enhances chemosensitivity to temozolomide in drug-resistant glioblastoma. Cancer Lett. 2018 Nov 01; 436:10-21. PMID: 30102952.
    View in: PubMed
  2. El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathol. 2018 Oct; 136(4):537-555. PMID: 29982852.
    View in: PubMed
  3. Sadik N, Cruz L, Gurtner A, Rodosthenous RS, Dusoswa SA, Ziegler O, Van Solinge TS, Wei Z, Salvador-Garicano AM, Gyorgy B, Broekman M, Balaj L. Extracellular RNAs: A New Awareness of Old Perspectives. Methods Mol Biol. 2018; 1740:1-15. PMID: 29388131.
    View in: PubMed
  4. Liu J, Lu SY, Wang YG, Wei ZY, Zhang HX. SPINK1 Gene is Significantly Associated With Pancreatitis: A Comprehensive Meta-Analysis. Pancreas. 2017 Nov/Dec; 46(10):1373-1380. PMID: 28984793.
    View in: PubMed
  5. Wei Z, Batagov AO, Schinelli S, Wang J, Wang Y, El Fatimy R, Rabinovsky R, Balaj L, Chen CC, Hochberg F, Carter B, Breakefield XO, Krichevsky AM. Coding and noncoding landscape of extracellular RNA released by human glioma stem cells. Nat Commun. 2017 10 26; 8(1):1145. PMID: 29074968.
    View in: PubMed
  6. Zhang Y, He X, Wu X, Lei M, Wei Z, Zhang X, Wen L, Xu P, Li S, Qu S. Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson's disease. Cell Death Dis. 2017 02 09; 8(2):e2611. PMID: 28182002.
    View in: PubMed
  7. Benyamin B, Maihofer AX, Schork AJ, Hamilton BA, Rao F, Schmid-Schönbein GW, Zhang K, Mahata M, Stridsberg M, Schork NJ, Biswas N, Hook VY, Wei Z, Montgomery GW, Martin NG, Nievergelt CM, Whitfield JB, O'Connor DT. Identification of novel loci affecting circulating chromogranins and related peptides. Hum Mol Genet. 2017 01 01; 26(1):233-242. PMID: 28011710.
    View in: PubMed
  8. Wang Y, Veremeyko T, Wong AH, El Fatimy R, Wei Z, Cai W, Krichevsky AM. Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease. Neurobiol Aging. 2017 03; 51:156-166. PMID: 28089352.
    View in: PubMed
  9. Wong HA, Fatimy RE, Onodera C, Wei Z, Yi M, Mohan A, Gowrisankaran S, Karmali P, Marcusson E, Wakimoto H, Stephens R, Uhlmann EJ, Song JS, Tannous B, Krichevsky AM. The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma. Mol Ther. 2015 Jul; 23(7):1234-1247. PMID: 28142001.
    View in: PubMed
  10. Wang Y, Wang J, Zhou Y, Wei Z, Xiao Y, Zhou K, Wen J, Yan J, Cai W. Contribution of Common Variants in GABRG2, RELN and NRG3 and Interaction Networks to the Risk of Hirschsprung Disease. Cell Physiol Biochem. 2016; 40(3-4):509-526. PMID: 27889765.
    View in: PubMed
  11. Zhou D, Wei Z, Kuang Z, Luo H, Ma J, Zeng X, Wang K, Liu B, Gong F, Wang J, Lei S, Wang D, Zeng J, Wang T, He Y, Yuan Y, Dai H, He L, Xing Q. A novel P53/POMC/Gas/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation. J Cell Mol Med. 2017 04; 21(4):802-815. PMID: 27885802.
    View in: PubMed
  12. Wei Z, Batagov AO, Carter DR, Krichevsky AM. Fetal Bovine Serum RNA Interferes with the Cell Culture derived Extracellular RNA. Sci Rep. 2016 08 09; 6:31175. PMID: 27503761.
    View in: PubMed
  13. Wang Y, Cao Y, Huang X, Yu T, Wei Z, McGrath J, Xu F, Bi Y, Li X, Yang F, Li W, Zou X, Peng Z, Xiao Y, Zhang Y, He L, He G. Allele-specific expression of mutated in colorectal cancer (MCC) gene and alternative susceptibility to colorectal cancer in schizophrenia. Sci Rep. 2016 05 26; 6:26688. PMID: 27226254.
    View in: PubMed
  14. Meng C, Wei Z, Zhang Y, Yan L, He H, Zhang L, Xing Q. Regulation of cytochrome P450 3A4 by small vault RNAb derived from the non-coding vault RNA1 of multidrug resistance-linked vault particle. Mol Med Rep. 2016 Jul; 14(1):387-93. PMID: 27177257.
    View in: PubMed
  15. Du H, Wei Z, Yan Y, Xiong Y, Zhang X, Shen L, Ruan Y, Wu X, Xu Q, He L, Qin S. Functional Characterization of Human CYP2C9 Allelic Variants in COS-7 Cells. Front Pharmacol. 2016; 7:98. PMID: 27199745; PMCID: PMC4843492.
  16. Liu S, da Cunha AP, Rezende RM, Cialic R, Wei Z, Bry L, Comstock LE, Gandhi R, Weiner HL. The Host Shapes the Gut Microbiota via Fecal MicroRNA. Cell Host Microbe. 2016 Jan 13; 19(1):32-43. PMID: 26764595; PMCID: PMC4847146 [Available on 01/13/17].
  17. Laurent LC, Abdel-Mageed AB, Adelson PD, Arango J, Balaj L, Breakefield X, Carlson E, Carter BS, Majem B, Chen CC, Cocucci E, Danielson K, Courtright A, Das S, Abd Elmageed ZY, Enderle D, Ezrin A, Ferrer M, Freedman J, Galas D, Gandhi R, Huentelman MJ, Van Keuren-Jensen K, Kalani Y, Kim Y, Krichevsky AM, Lai C, Lal-Nag M, Laurent CD, Leonardo T, Li F, Malenica I, Mondal D, Nejad P, Patel T, Raffai RL, Rubio R, Skog J, Spetzler R, Sun J, Tanriverdi K, Vickers K, Wang L, Wang Y, Wei Z, Weiner HL, Wong D, Yan IK, Yeri A, Gould S. Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. J Extracell Vesicles. 2015; 4:26533. PMID: 26320937.
    View in: PubMed
  18. Shi Y, Liu Y, Wei Z, Zhang Y, Zhang L, Jiang S, Xiong Y, Shen L, He L, Xing Q, Qin S. Hsa-miR-27a is involved in the regulation of CYP3A4 expression in human livers from Chinese Han population. Pharmacogenomics. 2015; 16(12):1379-86. PMID: 26229046.
    View in: PubMed
  19. Wong HA, Fatimy RE, Onodera C, Wei Z, Yi M, Mohan A, Gowrisankaran S, Karmali P, Marcusson E, Wakimoto H, Stephens R, Uhlmann EJ, Song JS, Tannous B, Krichevsky AM. The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma. Mol Ther. 2015 Jul; 23(7):1234-1247. PMID: 25903473; PMCID: PMC4817797.
  20. Huo R, Wei Z, Xiong Y, Jiang J, Liu Y, Yan Y, Shi J, Li W, Cui D, Xing Q, He L, Qin S. Association of dopamine receptor D1 (DRD1) polymorphisms with risperidone treatment response in Chinese schizophrenia patients. Neurosci Lett. 2015 Jan 01; 584:178-83. PMID: 25179995.
    View in: PubMed
  21. Wei Z, Jiang S, Zhang Y, Wang X, Peng X, Meng C, Liu Y, Wang H, Guo L, Qin S, He L, Shao F, Zhang L, Xing Q. The effect of microRNAs in the regulation of human CYP3A4: a systematic study using a mathematical model. Sci Rep. 2014 Mar 05; 4:4283. PMID: 24594634; PMCID: PMC3942699.
  22. Zhang K, Huentelman MJ, Rao F, Sun EI, Corneveaux JJ, Schork AJ, Wei Z, Waalen J, Miramontes-Gonzalez JP, Hightower CM, Maihofer AX, Mahata M, Pastinen T, Ehret GB, Schork NJ, Eskin E, Nievergelt CM, Saier MH, O'Connor DT. Genetic implication of a novel thiamine transporter in human hypertension. J Am Coll Cardiol. 2014 Apr 22; 63(15):1542-55. PMID: 24509276; PMCID: PMC3992204.
  23. Xiong Y, Wei Z, Huo R, Wu X, Shen L, Li Y, Gong X, Wu Z, Feng G, Li W, He L, Xing Q, Qin S. A pharmacogenetic study of risperidone on chemokine (C-C motif) ligand 2 (CCL2) in Chinese Han schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 03; 51:153-8. PMID: 24495780.
    View in: PubMed
  24. Wu Z, Zhang X, Shen L, Xiong Y, Wu X, Huo R, Wei Z, Cai L, Qi G, Xu Q, Cui D, Cui D, Zhao G, He L, Qin S. A systematically combined genotype and functional combination analysis of CYP2E1, CYP2D6, CYP2C9, CYP2C19 in different geographic areas of mainland China--a basis for personalized therapy. PLoS One. 2013; 8(10):e71934. PMID: 24098323; PMCID: PMC3788764.
  25. Hightower CM, Zhang K, Miramontes-González JP, Rao F, Wei Z, Schork AJ, Nievergelt CM, Biswas N, Mahata M, Elkelis N, Taupenot L, Stridsberg M, Ziegler MG, O'Connor DT. Genetic variation at the delta-sarcoglycan (SGCD) locus elevates heritable sympathetic nerve activity in human twin pairs. J Neurochem. 2013 Dec; 127(6):750-61. PMID: 23786442; PMCID: PMC3833977.
  26. Wu X, Xu QQ, Guo L, Yu CT, Xiong YY, Wei ZY, Huo R, Li ST, Shen L, Niu JM, Liu L, Lin Y, He L, Qin SY. Quantitative assessment of the association between rs2046210 at 6q25.1 and breast cancer risk. PLoS One. 2013; 8(6):e65206. PMID: 23785413; PMCID: PMC3681980.
  27. Zhou D, Ji H, Wei Z, Guo L, Li Y, Wang T, Zhu Y, Dong X, Wang Y, He L, Xing Q, Zhang L. A novel insertional mutation in the connexin 46 (gap junction alpha 3) gene associated with autosomal dominant congenital cataract in a Chinese family. Mol Vis. 2013; 19:789-95. PMID: 23592915; PMCID: PMC3626289.
  28. Sun L, Li J, Zhou K, Zhang M, Yang J, Li Y, Ji B, Zhang Z, Zhu H, Yang L, He G, Gao L, Wei Z, Wang K, Han X, Liu W, Tan L, Yu Y, He L, Wan C. Metabolomic analysis reveals metabolic disturbance in the cortex and hippocampus of subchronic MK-801 treated rats. PLoS One. 2013; 8(4):e60598. PMID: 23577129; PMCID: PMC3618452.
  29. Wei Z, Wang L, Yu T, Wang Y, Sun L, Wang T, Huo R, Li Y, Wu X, Qin S, Xu Y, Feng G, He L, Xing Q. Histamine H4 receptor polymorphism: a potential predictor of risperidone efficacy. J Clin Psychopharmacol. 2013 Apr; 33(2):221-5. PMID: 23422377.
    View in: PubMed
  30. Wei Z, Chen M, Zhang Y, Wang X, Jiang S, Wang Y, Wu X, Qin S, He L, Zhang L, Xing Q. No correlation of hsa-miR-148a with expression of PXR or CYP3A4 in human livers from Chinese Han population. PLoS One. 2013; 8(3):e59141. PMID: 23527115.
    View in: PubMed
  31. Gong X, Liu Y, Zhang X, Wei Z, Huo R, Shen L, He L, Qin S. Systematic functional study of cytochrome P450 2D6 promoter polymorphisms in the Chinese Han population. PLoS One. 2013; 8(2):e57764. PMID: 23469064; PMCID: PMC3585152.
  32. Zhou D, Wei Z, Deng S, Wang T, Zai M, Wang H, Guo L, Zhang J, Zhong H, He L, Xing Q. SASH1 regulates melanocyte transepithelial migration through a novel Gas-SASH1-IQGAP1-E-Cadherin dependent pathway. Cell Signal. 2013 Jun; 25(6):1526-38. PMID: 23333244.
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  33. Wei Z, Zhang K, Wen G, Balasubramanian K, Shih PA, Rao F, Friese RS, Miramontes-Gonzalez JP, Schmid-Schoenbein GW, Kim HS, Mahata SK, O'Connor DT. Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs. J Hypertens. 2013 Jan; 31(1):123-33. PMID: 23149563; PMCID: PMC3615981.
  34. Mbewe-Campbell N, Wei Z, Zhang K, Friese RS, Mahata M, Schork AJ, Rao F, Chiron S, Biswas N, Kim HS, Mahata SK, Waalen J, Nievergelt CM, Hook VY, O'Connor DT. Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure. J Hypertens. 2012 Oct; 30(10):1961-9. PMID: 22871890; PMCID: PMC3478326.
  35. Li Y, Zhou K, Zhang Z, Sun L, Yang J, Zhang M, Ji B, Tang K, Wei Z, He G, Gao L, Yang L, Wang P, Yang P, Feng G, He L, Wan C. Label-free quantitative proteomic analysis reveals dysfunction of complement pathway in peripheral blood of schizophrenia patients: evidence for the immune hypothesis of schizophrenia. Mol Biosyst. 2012 Oct; 8(10):2664-71. PMID: 22797129.
    View in: PubMed
  36. Cao ZH, Wei ZY, Zhu QY, Zhang JY, Yang L, Qin SY, Shao LY, Zhang YT, Xuan JK, Li QL, Xu JH, Xu F, Ma L, Huang HY, Xing QH, Luo XQ. HLA-B*58:01 allele is associated with augmented risk for both mild and severe cutaneous adverse reactions induced by allopurinol in Han Chinese. Pharmacogenomics. 2012 Jul; 13(10):1193-201. PMID: 22909208.
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  37. Shao L, Wang L, Wei Z, Xiong Y, Wang Y, Tang K, Li Y, Feng G, Xing Q, He L. Dynamic network of transcription and pathway crosstalk to reveal molecular mechanism of MGd-treated human lung cancer cells. PLoS One. 2012; 7(5):e31984. PMID: 22693540; PMCID: PMC3365074.
  38. Huo R, Tang K, Wei Z, Shen L, Xiong Y, Wu X, Niu J, Han X, Tian Z, Yang L, Feng G, He L, Qin S. Genetic polymorphisms in CYP2E1: association with schizophrenia susceptibility and risperidone response in the Chinese Han population. PLoS One. 2012; 7(5):e34809. PMID: 22606226; PMCID: PMC3350493.
  39. Wu X, Tang KF, Li Y, Xiong YY, Shen L, Wei ZY, Zhou KJ, Niu JM, Han X, Yang L, Feng GY, He L, Qin SY. Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson's disease: a meta-analysis. Parkinsonism Relat Disord. 2012 Jul; 18(6):722-30. PMID: 22575234.
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  40. Li T, Zeng Z, Zhao Q, Wang T, Huang K, Li J, Li Y, Liu J, Wei Z, Wang Y, Feng G, He L, Shi Y. FoxP2 is significantly associated with schizophrenia and major depression in the Chinese Han population. World J Biol Psychiatry. 2013 Mar; 14(2):146-50. PMID: 22404659.
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  41. Wang H, Wang X, Li Q, Chen S, Liu L, Wei Z, Wang L, Liu Y, Zhao X, He L, Wang J, Xing Q. Analysis of JAG1 gene variant in Chinese patients with Alagille syndrome. Gene. 2012 May 10; 499(1):191-3. PMID: 22405927.
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  42. Rao F, Chiron S, Wei Z, Fung MM, Chen Y, Wen G, Khandrika S, Ziegler MG, Benyamin B, Montgomery G, Whitfield JB, Martin NG, Waalen J, Hamilton BA, Mahata SK, O'Connor DT. Genetic variation within a metabolic motif in the chromogranin a promoter: pleiotropic influence on cardiometabolic risk traits in twins. Am J Hypertens. 2012 Jan; 25(1):29-40. PMID: 21918574; PMCID: PMC3664223.
  43. Wei Z, Wang L, Zhang M, Xuan J, Wang Y, Liu B, Shao L, Li J, Zeng Z, Li T, Liu J, Wang T, Zhang M, Qin S, Xu Y, Feng G, He L, Xing Q. A pharmacogenetic study of risperidone on histamine H3 receptor gene (HRH3) in Chinese Han schizophrenia patients. J Psychopharmacol. 2012 Jun; 26(6):813-8. PMID: 21652606.
    View in: PubMed
  44. Li Y, Tang K, Zhou K, Wei Z, Zeng Z, He L, Wan C. Quantitative assessment of the effect of ABCA1 R219K polymorphism on the risk of coronary heart disease. Mol Biol Rep. 2012 Feb; 39(2):1809-13. PMID: 21643759.
    View in: PubMed
  45. Wei Z, Biswas N, Wang L, Courel M, Zhang K, Soler-Jover A, Taupenot L, O'Connor DT. A common genetic variant in the 3'-UTR of vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA motif to alter chromogranin A processing and hypertension risk. Circ Cardiovasc Genet. 2011 Aug 01; 4(4):381-9. PMID: 21558123; PMCID: PMC3319682.
  46. Chiron S, Wei Z, Chen Y, Zhang K, Wen G, Fischer WH, Mahata SK, O'Connor DT. Proteomic analysis yields an unexpected trans-acting point in control of the human sympathochromaffin phenotype. Circ Cardiovasc Genet. 2011 Aug 01; 4(4):437-45. PMID: 21551321; PMCID: PMC3319683.
  47. Zhang M, Huang K, Zhang Z, Ji B, Zhu H, Zhou K, Li Y, Yang J, Sun L, Wei Z, He G, Gao L, He L, Wan C. Proteome alterations of cortex and hippocampus tissues in mice subjected to vitamin A depletion. J Nutr Biochem. 2011 Nov; 22(11):1003-8. PMID: 21190828.
    View in: PubMed
  48. Liu J, Zhou G, Ji W, Li J, Li T, Wang T, Li Y, Zeng Z, Hu Z, Zheng L, Ji J, Wang Y, Wei Z, Feng G, He L, Shi Y. No association of the YWHAE gene with schizophrenia, major depressive disorder or bipolar disorder in the Han Chinese population. Behav Genet. 2011 Jul; 41(4):557-64. PMID: 21184166.
    View in: PubMed
  49. Wang T, Zeng Z, Li T, Liu J, Li J, Li Y, Zhao Q, Wei Z, Wang Y, Li B, Feng G, He L, Shi Y. Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population. PLoS One. 2010 Oct 27; 5(10):e13662. PMID: 21048971; PMCID: PMC2965102.
  50. Wang Y, Zhang J, Liu B, Shao L, Wei Z, Li X, Ji J, Yang F, Wang T, Liu J, Wan C, Li B, Xu Y, Feng G, He L, He G. Genetic polymorphisms in the SCN8A gene are associated with suicidal behavior in psychiatric disorders in the Chinese population. World J Biol Psychiatry. 2010 Dec; 11(8):956-63. PMID: 20632842.
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  51. Liu BC, Zhang J, Wang L, Li XW, Wang Y, Wei ZY, Ji J, Yang FP, Wan CL, Xu YF, Feng GY, He L, He G. HTR2C promoter polymorphisms are associated with risperidone efficacy in Chinese female patients. Pharmacogenomics. 2010 May; 11(5):685-92. PMID: 20415561.
    View in: PubMed
  52. Wang L, Wang Y, Zhang X, Shi J, Wang M, Wei Z, Zhao A, Li B, Zhao X, Xing Q, He L. Common genetic variation in MTNR1B is associated with serum testosterone, glucose tolerance, and insulin secretion in polycystic ovary syndrome patients. Fertil Steril. 2010 Nov; 94(6):2486-9, 2489.e1-2. PMID: 20207350.
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  53. Zeng Z, Li L, Zhang Z, Li Y, Wei Z, Huang K, He L, Shi Y. A meta-analysis of three polymorphisms in the endothelial nitric oxide synthase gene (NOS3) and their effect on the risk of diabetic nephropathy. Hum Genet. 2010 Apr; 127(4):373-81. PMID: 20049477.
    View in: PubMed
  54. Xing Y, Yang L, Wang L, Shao L, Wei Z, Xuan J, Li J, Qin S, Shu A, He L, Xing Q. Systematic screening for polymorphisms within the UGT1A6 gene in three Chinese populations and function prediction through structural modeling. Pharmacogenomics. 2009 May; 10(5):741-52. PMID: 19450126.
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  55. Che R, Tang W, Zhang J, Wei Z, Zhang Z, Huang K, Zhao X, Gao J, Zhou G, Huang P, He L, Shi Y. No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis. BMC Med Genet. 2009 Apr 06; 10:31. PMID: 19348671; PMCID: PMC2670820.
  56. Li J, Zhang F, Gao J, Cai Z, Zhao Q, Xing Y, Xu J, Liu Y, Shao L, Che R, Wei Z, He L. An association study of the SLC26A4 gene in children with mental retardation. Neurosci Lett. 2009 Jul 03; 457(3):155-8. PMID: 19429184.
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  57. Wei Z, Wang L, Xuan J, Che R, Du J, Qin S, Xing Y, Gu B, Yang L, Li H, Li J, Feng G, He L, Xing Q. Association analysis of serotonin receptor 7 gene (HTR7) and risperidone response in Chinese schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30; 33(3):547-51. PMID: 19233240.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.