Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

David Ginty, Ph.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AT011447 (GINTY, DAVID D) Sep 15, 2020 - Aug 31, 2023
    Spinal Cord Nociceptive Circuits that Deliver Outputs to the Brain to Initiate Pain
    Role: Principal Investigator
  2. R01NS103905 (GINTY, DAVID D) Mar 1, 2019 - Jan 31, 2024
    Circuit-specific transcriptional mechanisms underlying the precision of synaptic connectivity
    Role: Principal Investigator
  3. R01NS110713 (GINTY, DAVID D) Feb 1, 2019 - Jan 31, 2024
    A new molecular code for the development of synapse specificity
    Role: Principal Investigator
  4. R35NS097344 (GINTY, DAVID D) Sep 1, 2016 - Aug 31, 2024
    Elucidating cutaneous mechanosensory circuits, from development to disease
    Role: Principal Investigator
  5. P50MH100024 (HUGANIR, RICHARD L) May 22, 2013 - Mar 31, 2018
    Plasticity at the Excitatory Synapse
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Handler A, Ginty DD. The mechanosensory neurons of touch and their mechanisms of activation. Nat Rev Neurosci. 2021 Sep; 22(9):521-537. PMID: 34312536.
    Citations:    Fields:    
  2. Jeon SM, Chang D, Geske A, Ginty DD, Caterina MJ. Sex-Dependent Reduction in Mechanical Allodynia in the Sural-Sparing Nerve Injury Model in Mice Lacking Merkel Cells. J Neurosci. 2021 Jun 30; 41(26):5595-5619. PMID: 34031166.
    Citations:    Fields:    
  3. Santiago IJ, Zhang D, Saras A, Pontillo N, Xu C, Chen X, Weirauch MT, Mistry M, Ginty DD, Pecot MY, Peng J. Drosophila Fezf functions as a transcriptional repressor to direct layer-specific synaptic connectivity in the fly visual system. Proc Natl Acad Sci U S A. 2021 Mar 30; 118(13). PMID: 33766917.
    Citations: 1     Fields:    
  4. Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. Author Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3ß-S100b axis. Nature. 2021 Feb; 590(7845):E31-E33. PMID: 33536624.
    Citations:    Fields:    
  5. Choi S, Hachisuka J, Brett MA, Magee AR, Omori Y, Iqbal NU, Zhang D, DeLisle MM, Wolfson RL, Bai L, Santiago C, Gong S, Goulding M, Heintz N, Koerber HR, Ross SE, Ginty DD. Parallel ascending spinal pathways for affective touch and pain. Nature. 2020 11; 587(7833):258-263. PMID: 33116307.
    Citations: 7     Fields:    Translation:AnimalsCells
  6. Neubarth NL, Emanuel AJ, Liu Y, Springel MW, Handler A, Zhang Q, Lehnert BP, Guo C, Orefice LL, Abdelaziz A, DeLisle MM, Iskols M, Rhyins J, Kim SJ, Cattel SJ, Regehr W, Harvey CD, Drugowitsch J, Ginty DD. Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception. Science. 2020 06 19; 368(6497). PMID: 32554568.
    Citations: 8     Fields:    Translation:AnimalsCells
  7. Sharma N, Flaherty K, Lezgiyeva K, Wagner DE, Klein AM, Ginty DD. The emergence of transcriptional identity in somatosensory neurons. Nature. 2020 01; 577(7790):392-398. PMID: 31915380.
    Citations: 43     Fields:    Translation:AnimalsCells
  8. Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD. Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models. Cell. 2019 08 08; 178(4):867-886.e24. PMID: 31398341.
    Citations: 26     Fields:    Translation:AnimalsCells
  9. Boyle KA, Gradwell MA, Yasaka T, Dickie AC, Polgár E, Ganley RP, Orr DPH, Watanabe M, Abraira VE, Kuehn ED, Zimmerman AL, Ginty DD, Callister RJ, Graham BA, Hughes DI. Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia. Cell Rep. 2019 07 09; 28(2):526-540.e6. PMID: 31291586.
    Citations: 14     Fields:    Translation:AnimalsCells
  10. Zheng Y, Liu P, Bai L, Trimmer JS, Bean BP, Ginty DD. Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties. Neuron. 2019 08 21; 103(4):598-616.e7. PMID: 31248728.
    Citations: 37     Fields:    Translation:AnimalsCells
  11. Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. Publisher Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3ß-S100b axis. Nature. 2019 Jun; 570(7760):E32. PMID: 31114060.
    Citations: 1     Fields:    
  12. Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. Innervation of thermogenic adipose tissue via a calsyntenin 3ß-S100b axis. Nature. 2019 05; 569(7755):229-235. PMID: 31043739.
    Citations: 23     Fields:    Translation:AnimalsCells
  13. Kuehn ED, Meltzer S, Abraira VE, Ho CY, Ginty DD. Tiling and somatotopic alignment of mammalian low-threshold mechanoreceptors. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9168-9177. PMID: 30996124.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  14. Zhang Q, Lee WA, Paul DL, Ginty DD. Multiplexed peroxidase-based electron microscopy labeling enables simultaneous visualization of multiple cell types. Nat Neurosci. 2019 05; 22(5):828-839. PMID: 30886406.
    Citations: 11     Fields:    Translation:AnimalsCells
  15. Zimmerman AL, Kovatsis EM, Pozsgai RY, Tasnim A, Zhang Q, Ginty DD. Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior. Neuron. 2019 04 17; 102(2):420-434.e8. PMID: 30826183.
    Citations: 15     Fields:    Translation:AnimalsCells
  16. Ye M, Lehigh KM, Ginty DD. Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling. Elife. 2018 01 30; 7. PMID: 29381137.
    Citations: 17     Fields:    Translation:AnimalsCells
  17. Wang Q, Chiu SL, Koropouli E, Hong I, Mitchell S, Easwaran TP, Hamilton NR, Gustina AS, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. Neuron. 2017 Dec 06; 96(5):1084-1098.e7. PMID: 29154130.
    Citations: 21     Fields:    Translation:AnimalsCells
  18. Browne LE, Latremoliere A, Lehnert BP, Grantham A, Ward C, Alexandre C, Costigan M, Michoud F, Roberson DP, Ginty DD, Woolf CJ. Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses. Cell Rep. 2017 07 05; 20(1):89-98. PMID: 28683326.
    Citations: 7     Fields:    Translation:AnimalsCells
  19. Severson KS, Xu D, Van de Loo M, Bai L, Ginty DD, O'Connor DH. Active Touch and Self-Motion Encoding by Merkel Cell-Associated Afferents. Neuron. 2017 May 03; 94(3):666-676.e9. PMID: 28434802.
    Citations: 28     Fields:    Translation:AnimalsCells
  20. Andreone BJ, Chow BW, Tata A, Lacoste B, Ben-Zvi A, Bullock K, Deik AA, Ginty DD, Clish CB, Gu C. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron. 2017 May 03; 94(3):581-594.e5. PMID: 28416077.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  21. Lehigh KM, West KM, Ginty DD. Retrogradely Transported TrkA Endosomes Signal Locally within Dendrites to Maintain Sympathetic Neuron Synapses. Cell Rep. 2017 04 04; 19(1):86-100. PMID: 28380365.
    Citations: 12     Fields:    Translation:AnimalsCells
  22. Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O'Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, Ginty DD. The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017 Jan 12; 168(1-2):295-310.e19. PMID: 28041852.
    Citations: 86     Fields:    Translation:AnimalsCells
  23. Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD. Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs. Cell. 2016 Jul 14; 166(2):299-313. PMID: 27293187.
    Citations: 84     Fields:    Translation:AnimalsCells
  24. Bai L, Lehnert BP, Liu J, Neubarth NL, Dickendesher TL, Nwe PH, Cassidy C, Woodbury CJ, Ginty DD. Genetic Identification of an Expansive Mechanoreceptor Sensitive to Skin Stroking. Cell. 2015 Dec 17; 163(7):1783-1795. PMID: 26687362.
    Citations: 47     Fields:    Translation:AnimalsCells
  25. Huang S, O'Donovan KJ, Turner EE, Zhong J, Ginty DD. Extrinsic and intrinsic signals converge on the Runx1/CBFß transcription factor for nonpeptidergic nociceptor maturation. Elife. 2015 Sep 29; 4:e10874. PMID: 26418744.
    Citations: 9     Fields:    Translation:AnimalsCells
  26. Rutlin M, Ho CY, Abraira VE, Cassidy C, Bai L, Woodbury CJ, Ginty DD. The Cellular and Molecular Basis of Direction Selectivity of Ad-LTMRs. Cell. 2015 02 26; 160(5):1027. PMID: 29698636.
    Citations: 3     Fields:    
  27. Rutlin M, Ho CY, Abraira VE, Cassidy C, Bai L, Woodbury CJ, Ginty DD. The cellular and molecular basis of direction selectivity of Ad-LTMRs. Cell. 2014 Dec 18; 159(7):1640-51. PMID: 25525881.
    Citations: 46     Fields:    Translation:AnimalsCells
  28. Zimmerman A, Bai L, Ginty DD. The gentle touch receptors of mammalian skin. Science. 2014 Nov 21; 346(6212):950-4. PMID: 25414303.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  29. de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabhushi R, Ginty DD, Kolodkin AL, Tsai LH. Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. Nat Neurosci. 2014 Nov 21; 17(12):1840. PMID: 25413093.
  30. Mandai K, Reimert DV, Ginty DD. Linx mediates interaxonal interactions and formation of the internal capsule. Neuron. 2014 Jul 02; 83(1):93-103. PMID: 24930700.
    Citations: 14     Fields:    Translation:AnimalsCells
  31. Li L, Ginty DD. The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles. Elife. 2014 Feb 25; 3:e01901. PMID: 24569481.
    Citations: 31     Fields:    Translation:AnimalsCells
  32. Engelhard C, Sarsfield S, Merte J, Wang Q, Li P, Beppu H, Kolodkin AL, Sucov HM, Ginty DD. MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons. Elife. 2013 Sep 17; 2:e01160. PMID: 24052814.
    Citations: 10     Fields:    Translation:AnimalsCells
  33. Abraira VE, Ginty DD. The sensory neurons of touch. Neuron. 2013 Aug 21; 79(4):618-39. PMID: 23972592.
    Citations: 298     Fields:    Translation:AnimalsCells
  34. Harrington AW, Ginty DD. Long-distance retrograde neurotrophic factor signalling in neurons. Nat Rev Neurosci. 2013 Mar; 14(3):177-87. PMID: 23422909.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  35. Liu Y, Rutlin M, Huang S, Barrick CA, Wang F, Jones KR, Tessarollo L, Ginty DD. Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland. Science. 2012 Dec 07; 338(6112):1357-60. PMID: 23224557.
    Citations: 26     Fields:    Translation:AnimalsCells
  36. Wright KM, Lyon KA, Leung H, Leahy DJ, Ma L, Ginty DD. Dystroglycan organizes axon guidance cue localization and axonal pathfinding. Neuron. 2012 Dec 06; 76(5):931-44. PMID: 23217742.
    Citations: 68     Fields:    Translation:AnimalsCells
  37. de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabhushi R, Ginty DD, Kolodkin AL, Tsai LH. Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. Nat Neurosci. 2012 Jun 10; 15(7):1022-31. PMID: 22683681.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  38. Li L, Rutlin M, Abraira VE, Cassidy C, Kus L, Gong S, Jankowski MP, Luo W, Heintz N, Koerber HR, Woodbury CJ, Ginty DD. The functional organization of cutaneous low-threshold mechanosensory neurons. Cell. 2011 Dec 23; 147(7):1615-27. PMID: 22196735.
    Citations: 249     Fields:    Translation:AnimalsCells
  39. Harrington AW, St Hillaire C, Zweifel LS, Glebova NO, Philippidou P, Halegoua S, Ginty DD. Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival. Cell. 2011 Aug 05; 146(3):421-34. PMID: 21816277.
    Citations: 62     Fields:    Translation:AnimalsCells
  40. Guo T, Mandai K, Condie BG, Wickramasinghe SR, Capecchi MR, Ginty DD. An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. Nat Neurosci. 2011 Jan; 14(1):31-6. PMID: 21151121.
    Citations: 24     Fields:    Translation:AnimalsCells
  41. Sharma N, Deppmann CD, Harrington AW, St Hillaire C, Chen ZY, Lee FS, Ginty DD. Long-distance control of synapse assembly by target-derived NGF. Neuron. 2010 Aug 12; 67(3):422-34. PMID: 20696380.
    Citations: 57     Fields:    Translation:AnimalsCells
  42. Smith-Hicks C, Xiao B, Deng R, Ji Y, Zhao X, Shepherd JD, Posern G, Kuhl D, Huganir RL, Ginty DD, Worley PF, Linden DJ. SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells. Nat Neurosci. 2010 Sep; 13(9):1082-9. PMID: 20694003.
    Citations: 27     Fields:    Translation:AnimalsCells
  43. Merte J, Wang Q, Vander Kooi CW, Sarsfield S, Leahy DJ, Kolodkin AL, Ginty DD. A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal. J Neurosci. 2010 Apr 21; 30(16):5767-75. PMID: 20410128.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  44. Luo W, Enomoto H, Rice FL, Milbrandt J, Ginty DD. Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron. 2009 Dec 24; 64(6):841-56. PMID: 20064391.
    Citations: 107     Fields:    Translation:AnimalsCells
  45. Tran TS, Rubio ME, Clem RL, Johnson D, Case L, Tessier-Lavigne M, Huganir RL, Ginty DD, Kolodkin AL. Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS. Nature. 2009 Dec 24; 462(7276):1065-9. PMID: 20010807.
    Citations: 116     Fields:    Translation:AnimalsCells
  46. Merte J, Jensen D, Wright K, Sarsfield S, Wang Y, Schekman R, Ginty DD. Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat Cell Biol. 2010 Jan; 12(1):41-6; sup pp 1-8. PMID: 19966784.
    Citations: 101     Fields:    Translation:AnimalsCells
  47. Kolk SM, Gunput RA, Tran TS, van den Heuvel DM, Prasad AA, Hellemons AJ, Adolfs Y, Ginty DD, Kolodkin AL, Burbach JP, Smidt MP, Pasterkamp RJ. Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. J Neurosci. 2009 Oct 07; 29(40):12542-57. PMID: 19812329.
    Citations: 49     Fields:    Translation:AnimalsCells
  48. Mandai K, Guo T, St Hillaire C, Meabon JS, Kanning KC, Bothwell M, Ginty DD. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron. 2009 Sep 10; 63(5):614-27. PMID: 19755105.
    Citations: 36     Fields:    Translation:AnimalsCells
  49. Newbern J, Zhong J, Wickramasinghe RS, Li X, Wu Y, Samuels I, Cherosky N, Karlo JC, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman YQ, Charron J, Ginty DD, Watanabe M, Saitta SC, Snider WD, Landreth GE. Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17115-20. PMID: 18952847.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  50. Johnson AW, Chen X, Crombag HS, Zhang C, Smith DR, Shokat KM, Gallagher M, Holland PC, Ginty DD. The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value. Eur J Neurosci. 2008 Sep; 28(5):997-1002. PMID: 18671735.
    Citations: 15     Fields:    Translation:AnimalsCells
  51. Wickramasinghe SR, Alvania RS, Ramanan N, Wood JN, Mandai K, Ginty DD. Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron. 2008 May 22; 58(4):532-45. PMID: 18498735.
    Citations: 65     Fields:    Translation:AnimalsCells
  52. Makita T, Sucov HM, Gariepy CE, Yanagisawa M, Ginty DD. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature. 2008 Apr 10; 452(7188):759-63. PMID: 18401410.
    Citations: 63     Fields:    Translation:AnimalsCells
  53. Deppmann CD, Mihalas S, Sharma N, Lonze BE, Niebur E, Ginty DD. A model for neuronal competition during development. Science. 2008 Apr 18; 320(5874):369-73. PMID: 18323418.
    Citations: 78     Fields:    Translation:AnimalsCells
  54. Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty DD. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007 Jun 07; 54(5):739-54. PMID: 17553423.
    Citations: 104     Fields:    Translation:AnimalsCells
  55. Deppmann CD, Ginty DD. Retrograde control of neural circuit formation. Cell. 2006 Dec 29; 127(7):1306-7. PMID: 17190596.
    Citations: 1     Fields:    Translation:AnimalsCells
  56. Alvania RS, Chen X, Ginty DD. Calcium signals control Wnt-dependent dendrite growth. Neuron. 2006 Jun 15; 50(6):813-5. PMID: 16772162.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  57. Riccio A, Alvania RS, Lonze BE, Ramanan N, Kim T, Huang Y, Dawson TM, Snyder SH, Ginty DD. A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol Cell. 2006 Jan 20; 21(2):283-94. PMID: 16427017.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  58. Huber AB, Kania A, Tran TS, Gu C, De Marco Garcia N, Lieberam I, Johnson D, Jessell TM, Ginty DD, Kolodkin AL. Distinct roles for secreted semaphorin signaling in spinal motor axon guidance. Neuron. 2005 Dec 22; 48(6):949-64. PMID: 16364899.
    Citations: 83     Fields:    Translation:AnimalsCells
  59. Lee J, Kim CH, Simon DK, Aminova LR, Andreyev AY, Kushnareva YE, Murphy AN, Lonze BE, Kim KS, Ginty DD, Ferrante RJ, Ryu H, Ratan RR. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005 Dec 09; 280(49):40398-401. PMID: 16207717.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  60. Zweifel LS, Kuruvilla R, Ginty DD. Functions and mechanisms of retrograde neurotrophin signalling. Nat Rev Neurosci. 2005 Aug; 6(8):615-25. PMID: 16062170.
    Citations: 165     Fields:    Translation:HumansAnimalsCells
  61. Valdez G, Akmentin W, Philippidou P, Kuruvilla R, Ginty DD, Halegoua S. Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors. J Neurosci. 2005 May 25; 25(21):5236-47. PMID: 15917464.
    Citations: 66     Fields:    Translation:AnimalsCells
  62. Ramanan N, Shen Y, Sarsfield S, Lemberger T, Schütz G, Linden DJ, Ginty DD. SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat Neurosci. 2005 Jun; 8(6):759-67. PMID: 15880109.
    Citations: 91     Fields:    Translation:AnimalsCells
  63. Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005 Apr 07; 46(1):13-21. PMID: 15820690.
    Citations: 133     Fields:    Translation:AnimalsCells
  64. Sahay A, Kim CH, Sepkuty JP, Cho E, Huganir RL, Ginty DD, Kolodkin AL. Secreted semaphorins modulate synaptic transmission in the adult hippocampus. J Neurosci. 2005 Apr 06; 25(14):3613-20. PMID: 15814792.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  65. Glebova NO, Ginty DD. Growth and survival signals controlling sympathetic nervous system development. Annu Rev Neurosci. 2005; 28:191-222. PMID: 16022594.
    Citations: 103     Fields:    Translation:AnimalsCells
  66. Miano JM, Ramanan N, Georger MA, de Mesy Bentley KL, Emerson RL, Balza RO, Xiao Q, Weiler H, Ginty DD, Misra RP. Restricted inactivation of serum response factor to the cardiovascular system. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):17132-7. PMID: 15569937.
    Citations: 119     Fields:    Translation:Animals
  67. Chen AE, Ginty DD, Fan CM. Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins. Nature. 2005 Jan 20; 433(7023):317-22. PMID: 15568017.
    Citations: 107     Fields:    Translation:AnimalsCells
  68. Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD. Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 2005 Jan 14; 307(5707):265-8. PMID: 15550623.
    Citations: 183     Fields:    Translation:AnimalsCells
  69. Schwarz Q, Gu C, Fujisawa H, Sabelko K, Gertsenstein M, Nagy A, Taniguchi M, Kolodkin AL, Ginty DD, Shima DT, Ruhrberg C. Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve. Genes Dev. 2004 Nov 15; 18(22):2822-34. PMID: 15545635.
    Citations: 76     Fields:    Translation:AnimalsCells
  70. Cloutier JF, Sahay A, Chang EC, Tessier-Lavigne M, Dulac C, Kolodkin AL, Ginty DD. Differential requirements for semaphorin 3F and Slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections. J Neurosci. 2004 Oct 13; 24(41):9087-96. PMID: 15483127.
    Citations: 29     Fields:    Translation:AnimalsCells
  71. Kuruvilla R, Zweifel LS, Glebova NO, Lonze BE, Valdez G, Ye H, Ginty DD. A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell. 2004 Jul 23; 118(2):243-55. PMID: 15260993.
    Citations: 135     Fields:    Translation:AnimalsCells
  72. Glebova NO, Ginty DD. Heterogeneous requirement of NGF for sympathetic target innervation in vivo. J Neurosci. 2004 Jan 21; 24(3):743-51. PMID: 14736860.
    Citations: 87     Fields:    Translation:AnimalsCells
  73. Sahay A, Molliver ME, Ginty DD, Kolodkin AL. Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events. J Neurosci. 2003 Jul 30; 23(17):6671-80. PMID: 12890759.
    Citations: 59     Fields:    Translation:AnimalsCells
  74. Ye H, Kuruvilla R, Zweifel LS, Ginty DD. Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons. Neuron. 2003 Jul 03; 39(1):57-68. PMID: 12848932.
    Citations: 84     Fields:    Translation:AnimalsCells
  75. Gu C, Rodriguez ER, Reimert DV, Shu T, Fritzsch B, Richards LJ, Kolodkin AL, Ginty DD. Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell. 2003 Jul; 5(1):45-57. PMID: 12852851.
    Citations: 276     Fields:    Translation:AnimalsCells
  76. Huber AB, Kolodkin AL, Ginty DD, Cloutier JF. Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance. Annu Rev Neurosci. 2003; 26:509-63. PMID: 12677003.
    Citations: 233     Fields:    Translation:AnimalsCells
  77. Lonze BE, Ginty DD. Function and regulation of CREB family transcription factors in the nervous system. Neuron. 2002 Aug 15; 35(4):605-23. PMID: 12194863.
    Citations: 665     Fields:    Translation:HumansAnimalsCells
  78. Ginty DD, Segal RA. Retrograde neurotrophin signaling: Trk-ing along the axon. Curr Opin Neurobiol. 2002 Jun; 12(3):268-74. PMID: 12049932.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  79. Dawson TM, Ginty DD. CREB family transcription factors inhibit neuronal suicide. Nat Med. 2002 May; 8(5):450-1. PMID: 11984583.
    Citations: 15     Fields:    Translation:HumansCells
  80. Riccio A, Ginty DD. What a privilege to reside at the synapse: NMDA receptor signaling to CREB. Nat Neurosci. 2002 May; 5(5):389-90. PMID: 11976696.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  81. Lonze BE, Riccio A, Cohen S, Ginty DD. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron. 2002 Apr 25; 34(3):371-85. PMID: 11988169.
    Citations: 108     Fields:    Translation:AnimalsCells
  82. Cloutier JF, Giger RJ, Koentges G, Dulac C, Kolodkin AL, Ginty DD. Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons. Neuron. 2002 Mar 14; 33(6):877-92. PMID: 11906695.
    Citations: 29     Fields:    Translation:AnimalsCells
  83. Gu C, Limberg BJ, Whitaker GB, Perman B, Leahy DJ, Rosenbaum JS, Ginty DD, Kolodkin AL. Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165. J Biol Chem. 2002 May 17; 277(20):18069-76. PMID: 11886873.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  84. Qian X, Ginty DD. SH2-B and APS are multimeric adapters that augment TrkA signaling. Mol Cell Biol. 2001 Mar; 21(5):1613-20. PMID: 11238898.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  85. Kuruvilla R, Ye H, Ginty DD. Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons. Neuron. 2000 Sep; 27(3):499-512. PMID: 11055433.
    Citations: 62     Fields:    Translation:AnimalsCells
  86. Sasaki M, Gonzalez-Zulueta M, Huang H, Herring WJ, Ahn S, Ginty DD, Dawson VL, Dawson TM. Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8617-22. PMID: 10900019.
    Citations: 41     Fields:    Translation:AnimalsCells
  87. Giger RJ, Cloutier JF, Sahay A, Prinjha RK, Levengood DV, Moore SE, Pickering S, Simmons D, Rastan S, Walsh FS, Kolodkin AL, Ginty DD, Geppert M. Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins. Neuron. 2000 Jan; 25(1):29-41. PMID: 10707970.
    Citations: 108     Fields:    Translation:AnimalsCells
  88. Riccio A, Ahn S, Davenport CM, Blendy JA, Ginty DD. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science. 1999 Dec 17; 286(5448):2358-61. PMID: 10600750.
    Citations: 192     Fields:    Translation:AnimalsCells
  89. Tsui-Pierchala BA, Ginty DD. Characterization of an NGF-P-TrkA retrograde-signaling complex and age-dependent regulation of TrkA phosphorylation in sympathetic neurons. J Neurosci. 1999 Oct 01; 19(19):8207-18. PMID: 10493722.
    Citations: 36     Fields:    Translation:AnimalsCells
  90. Ahn S, Ginty DD, Linden DJ. A late phase of cerebellar long-term depression requires activation of CaMKIV and CREB. Neuron. 1999 Jul; 23(3):559-68. PMID: 10433267.
    Citations: 41     Fields:    Translation:AnimalsCells
  91. Polleux F, Giger RJ, Ginty DD, Kolodkin AL, Ghosh A. Patterning of cortical efferent projections by semaphorin-neuropilin interactions. Science. 1998 Dec 04; 282(5395):1904-6. PMID: 9836643.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  92. Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 1998 Nov; 21(5):1213-21. PMID: 9856475.
    Citations: 85     Fields:    Translation:AnimalsCells
  93. Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL. Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity. Neuron. 1998 Nov; 21(5):1079-92. PMID: 9856463.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  94. Qian X, Riccio A, Zhang Y, Ginty DD. Identification and characterization of novel substrates of Trk receptors in developing neurons. Neuron. 1998 Nov; 21(5):1017-29. PMID: 9856458.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  95. Ahn S, Olive M, Aggarwal S, Krylov D, Ginty DD, Vinson C. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol Cell Biol. 1998 Feb; 18(2):967-77. PMID: 9447994.
    Citations: 187     Fields:    Translation:AnimalsCells
  96. Kolodkin AL, Ginty DD. Steering clear of semaphorins: neuropilins sound the retreat. Neuron. 1997 Dec; 19(6):1159-62. PMID: 9427240.
    Citations: 20     Fields:    Translation:AnimalsCells
  97. Riccio A, Pierchala BA, Ciarallo CL, Ginty DD. An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons. Science. 1997 Aug 22; 277(5329):1097-100. PMID: 9262478.
    Citations: 101     Fields:    Translation:AnimalsCells
  98. Xing J, Ginty DD, Greenberg ME. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science. 1996 Aug 16; 273(5277):959-63. PMID: 8688081.
    Citations: 282     Fields:    Translation:HumansAnimalsCells
  99. Miranti CK, Ginty DD, Huang G, Chatila T, Greenberg ME. Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase. Mol Cell Biol. 1995 Jul; 15(7):3672-84. PMID: 7791774.
    Citations: 49     Fields:    Translation:AnimalsCells
  100. Bonni A, Ginty DD, Dudek H, Greenberg ME. Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals. Mol Cell Neurosci. 1995 Apr; 6(2):168-83. PMID: 7551568.
    Citations: 73     Fields:    Translation:AnimalsCells
  101. Thompson MA, Ginty DD, Bonni A, Greenberg ME. L-type voltage-sensitive Ca2+ channel activation regulates c-fos transcription at multiple levels. J Biol Chem. 1995 Mar 03; 270(9):4224-35. PMID: 7876182.
    Citations: 21     Fields:    Translation:AnimalsCells
  102. Rosen LB, Ginty DD, Weber MJ, Greenberg ME. Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron. 1994 Jun; 12(6):1207-21. PMID: 8011335.
    Citations: 131     Fields:    Translation:AnimalsCells
  103. Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME. A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Mol Cell Biol. 1993 Oct; 13(10):6260-73. PMID: 8413226.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  104. Bading H, Ginty DD, Greenberg ME. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science. 1993 Apr 09; 260(5105):181-6. PMID: 8097060.
    Citations: 229     Fields:    Translation:AnimalsCells
  105. Ginty DD, Bading H, Greenberg ME. Trans-synaptic regulation of gene expression. Curr Opin Neurobiol. 1992 Jun; 2(3):312-6. PMID: 1322751.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  106. Ginty DD, Fanger GR, Wagner JA, Maue RA. The activity of cAMP-dependent protein kinase is required at a posttranslational level for induction of voltage-dependent sodium channels by peptide growth factors in PC12 cells. J Cell Biol. 1992 Mar; 116(6):1465-73. PMID: 1311713.
    Citations: 12     Fields:    Translation:AnimalsCells
  107. Ginty DD, Glowacka D, Bader DS, Hidaka H, Wagner JA. Induction of immediate early genes by Ca2+ influx requires cAMP-dependent protein kinase in PC12 cells. J Biol Chem. 1991 Sep 15; 266(26):17454-8. PMID: 1910045.
    Citations: 26     Fields:    Translation:Cells
  108. Ginty DD, Glowacka D, DeFranco C, Wagner JA. Nerve growth factor-induced neuronal differentiation after dominant repression of both type I and type II cAMP-dependent protein kinase activities. J Biol Chem. 1991 Aug 15; 266(23):15325-33. PMID: 1651325.
    Citations: 27     Fields:    Translation:AnimalsCells
  109. Scheibe RJ, Ginty DD, Wagner JA. Retinoic acid stimulates the differentiation of PC12 cells that are deficient in cAMP-dependent protein kinase. J Cell Biol. 1991 Jun; 113(5):1173-82. PMID: 1645738.
    Citations: 11     Fields:    Translation:AnimalsCells
  110. Ginty DD, Marlowe M, Pekala PH, Seidel ER. Multiple pathways for the regulation of ornithine decarboxylase in intestinal epithelial cells. Am J Physiol. 1990 Mar; 258(3 Pt 1):G454-60. PMID: 2107756.
    Citations: 3     Fields:    Translation:AnimalsCells
  111. Ginty DD, Osborne DL, Seidel ER. Putrescine stimulates DNA synthesis in intestinal epithelial cells. Am J Physiol. 1989 Jul; 257(1 Pt 1):G145-50. PMID: 2473652.
    Citations: 5     Fields:    Translation:AnimalsCells
  112. Ginty DD, Seidel ER. Polyamine-dependent growth and calmodulin-regulated induction of ornithine decarboxylase. Am J Physiol. 1989 Feb; 256(2 Pt 1):G342-8. PMID: 2493197.
    Citations: 3     Fields:    Translation:AnimalsCells
  113. Hargittai PT, Ginty DD, Lieberman EM. A pyrene fluorescence technique and microchamber for measurement of oxygen consumption of single isolated axons. Anal Biochem. 1987 Jun; 163(2):418-26. PMID: 3661989.
    Citations: 1     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.