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Christian Brendel, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Brendel C, Rio P, Verhoeyen E. Humanized mice are precious tools for evaluation of hematopoietic gene therapies and preclinical modeling to move towards a clinical trial. Biochem Pharmacol. 2019 Nov 11; 113711. PMID: 31726047.
    Citations:    
  2. Wu Y, Zeng J, Roscoe BP, Liu P, Yao Q, Lazzarotto CR, Clement K, Cole MA, Luk K, Baricordi C, Shen AH, Ren C, Esrick EB, Manis JP, Dorfman DM, Williams DA, Biffi A, Brugnara C, Biasco L, Brendel C, Pinello L, Tsai SQ, Wolfe SA, Bauer DE. Highly efficient therapeutic gene editing of human hematopoietic stem cells. Nat Med. 2019 05; 25(5):776-783. PMID: 30911135.
    Citations:    
  3. Xu S, Luk K, Yao Q, Shen AH, Zeng J, Wu Y, Luo HY, Brendel C, Pinello L, Chui DHK, Wolfe SA, Bauer DE. Editing aberrant splice sites efficiently restores ß-globin expression in ß-thalassemia. Blood. 2019 05 23; 133(21):2255-2262. PMID: 30704988.
    Citations:    Fields:    
  4. Chen-Wichmann L, Shvartsman M, Preiss C, Hockings C, Windisch R, Redondo Monte E, Leubolt G, Spiekermann K, Lausen J, Brendel C, Grez M, Greif PA, Wichmann C. Compatibility of RUNX1/ETO fusion protein modules driving CD34+ human progenitor cell expansion. Oncogene. 2019 01; 38(2):261-272. PMID: 30093631.
    Citations:    Fields:    
  5. Park HH, Triboulet R, Bentler M, Guda S, Du P, Xu H, Gregory RI, Brendel C, Williams DA. DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs. Mol Ther Nucleic Acids. 2018 Sep 07; 12:591-599. PMID: 30195795.
    Citations:    
  6. Brendel C, Rothe M, Santilli G, Charrier S, Stein S, Kunkel H, Abriss D, Müller-Kuller U, Gaspar B, Modlich U, Galy A, Schambach A, Thrasher AJ, Grez M. Non-Clinical Efficacy and Safety Studies on G1XCGD, a Lentiviral Vector for Ex Vivo Gene Therapy of X-Linked Chronic Granulomatous Disease. Hum Gene Ther Clin Dev. 2018 06; 29(2):69-79. PMID: 29664709.
    Citations:    Fields:    
  7. Bauer DE, Brendel C, Fitzhugh CD. Curative approaches for sickle cell disease: A review of allogeneic and autologous strategies. Blood Cells Mol Dis. 2017 09; 67:155-168. PMID: 28893518.
    Citations: 2     Fields:    Translation:HumansAnimals
  8. Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. J Clin Invest. 2016 10 03; 126(10):3868-3878. PMID: 27599293.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  9. Mino A, Troeger A, Brendel C, Cantor A, Harris C, Ciuculescu MF, Williams DA. RhoH participates in a multi-protein complex with the zinc finger protein kaiso that regulates both cytoskeletal structures and chemokine-induced T cells. Small GTPases. 2018 05 04; 9(3):260-273. PMID: 27574848.
    Citations:    Fields:    Translation:HumansCells
  10. Altrock PM, Brendel C, Renella R, Orkin SH, Williams DA, Michor F. Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease. Am J Hematol. 2016 09; 91(9):931-7. PMID: 27299299.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  11. Baranowski A, Klein A, Ritz U, Ackermann A, Anthonissen J, Kaufmann KB, Brendel C, Götz H, Rommens PM, Hofmann A. Surface Functionalization of Orthopedic Titanium Implants with Bone Sialoprotein. PLoS One. 2016; 11(4):e0153978. PMID: 27111551.
    Citations: 3     Fields:    
  12. Peano V, Houde M, Brendel C, Marquardt F, Clerk AA. Topological phase transitions and chiral inelastic transport induced by the squeezing of light. Nat Commun. 2016 Mar 02; 7:10779. PMID: 26931620.
    Citations: 4     Fields:    
  13. Weisser M, Demel UM, Stein S, Chen-Wichmann L, Touzot F, Santilli G, Sujer S, Brendel C, Siler U, Cavazzana M, Thrasher AJ, Reichenbach J, Essers MAG, Schwäble J, Grez M. Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions. J Allergy Clin Immunol. 2016 07; 138(1):219-228.e9. PMID: 26853280.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  14. Renner CIe, Outermans J, Ludwig R, Brendel C, Kwakkel G, Hummelsheim H. Group therapy task training versus individual task training during inpatient stroke rehabilitation: a randomised controlled trial. Clin Rehabil. 2016 Jul; 30(7):637-48. PMID: 26316552.
    Citations: 1     Fields:    Translation:Humans
  15. Lauter R, Brendel C, Habraken SJ, Marquardt F. Pattern phase diagram for two-dimensional arrays of coupled limit-cycle oscillators. Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Jul; 92(1):012902. PMID: 26274242.
    Citations:    Fields:    
  16. Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, Williams DA. miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Mol Ther. 2015 Sep; 23(9):1465-74. PMID: 26080908.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  17. Weber A, Borghouts C, Brendel C, Moriggl R, Delis N, Brill B, Vafaizadeh V, Groner B. Stat5 Exerts Distinct, Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl+ K562 and Jak2(V617F)+ HEL Leukemia Cells. Cancers (Basel). 2015 Mar 19; 7(1):503-37. PMID: 25809097.
    Citations: 4     
  18. Kays SK, Kaufmann KB, Abel T, Brendel C, Bonig H, Grez M, Buchholz CJ, Kneissl S. CD105 is a surface marker for receptor-targeted gene transfer into human long-term repopulating hematopoietic stem cells. Stem Cells Dev. 2015 Mar 15; 24(6):714-23. PMID: 25517513.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  19. Müller-Kuller U, Ackermann M, Kolodziej S, Brendel C, Fritsch J, Lachmann N, Kunkel H, Lausen J, Schambach A, Moritz T, Grez M. A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells. Nucleic Acids Res. 2015 Feb 18; 43(3):1577-92. PMID: 25605798.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  20. Schönfeld K, Sahm C, Zhang C, Naundorf S, Brendel C, Odendahl M, Nowakowska P, Bönig H, Köhl U, Kloess S, Köhler S, Holtgreve-Grez H, Jauch A, Schmidt M, Schubert R, Kühlcke K, Seifried E, Klingemann HG, Rieger MA, Tonn T, Grez M, Wels WS. Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor. Mol Ther. 2015 Feb; 23(2):330-8. PMID: 25373520.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  21. Brendel C, Goebel B, Daniela A, Brugman M, Kneissl S, Schwäble J, Kaufmann KB, Müller-Kuller U, Kunkel H, Chen-Wichmann L, Abel T, Serve H, Bystrykh L, Buchholz CJ, Grez M. CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells. Mol Ther. 2015 Jan; 23(1):63-70. PMID: 25189742.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  22. Brendel C, Kaufmann KB, Krattenmacher A, Pahujani S, Grez M. Generation of X-CGD cells for vector evaluation from healthy donor CD34(+) HSCs by shRNA-mediated knock down of gp91(phox). Mol Ther Methods Clin Dev. 2014; 1:14037. PMID: 26015977.
    Citations: 2     
  23. Brendel C, Williams DA. Unexpected help: mTOR meets lentiviral vectors. Blood. 2014 Aug 07; 124(6):832-3. PMID: 25104861.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  24. Kuhn S, Kroth J, Ritz U, Hofmann A, Brendel C, Müller LP, Förch R, Rommens PM. Reduced fibroblast adhesion and proliferation on plasma-modified titanium surfaces. J Mater Sci Mater Med. 2014 Nov; 25(11):2549-60. PMID: 25056198.
    Citations: 4     Fields:    Translation:HumansCells
  25. Steinbach JP, Zhang C, Burger M, Jennewein L, Schönfeld K, Genßler S, Sahm C, Brendel C, Naundorf S, Odendahl M, Köhl U, Nowakowska P, Seifried E, Bönig H, Tonn T, Grez M, Mittelbronn M, Wels WS. Erbb2/Her2-specific natural killer cells for adoptive immunotherapy of glioblastoma. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii44. PMID: 25165337.
    Citations:    
  26. Ciuculescu MF, Brendel C, Harris CE, Williams DA. Retroviral transduction of murine and human hematopoietic progenitors and stem cells. Methods Mol Biol. 2014; 1185:287-309. PMID: 25062637.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  27. Weber A, Borghouts C, Brendel C, Moriggl R, Delis N, Brill B, Vafaizadeh V, Groner B. The inhibition of stat5 by a Peptide aptamer ligand specific for the DNA binding domain prevents target gene transactivation and the growth of breast and prostate tumor cells. Pharmaceuticals (Basel). 2013 Aug 20; 6(8):960-87. PMID: 24276378.
    Citations: 9     
  28. Stein S, Scholz S, Schwäble J, Sadat MA, Modlich U, Schultze-Strasser S, Diaz M, Chen-Wichmann L, Müller-Kuller U, Brendel C, Fronza R, Kaufmann KB, Naundorf S, Pech NK, Travers JB, Matute JD, Presson RG, Sandusky GE, Kunkel H, Rudolf E, Dillmann A, von Kalle C, Kühlcke K, Baum C, Schambach A, Dinauer MC, Schmidt M, Grez M. From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease. Hum Gene Ther Clin Dev. 2013 Jun; 24(2):86-98. PMID: 23845071.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  29. Brendel C, Hänseler W, Wohlgensinger V, Bianchi M, Tokmak S, Chen-Wichmann L, Kuzmenko E, Cesarovic N, Nicholls F, Reichenbach J, Seger R, Grez M, Siler U. Human miR223 promoter as a novel myelo-specific promoter for chronic granulomatous disease gene therapy. Hum Gene Ther Methods. 2013 Jun; 24(3):151-9. PMID: 23489116.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  30. Vets S, De Rijck J, Brendel C, Grez M, Bushman F, Debyser Z, Gijsbers R. Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD. Mol Ther Nucleic Acids. 2013 Mar 05; 2:e77. PMID: 23462964.
    Citations: 7     
  31. Pfaff N, Lachmann N, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T. A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny. Stem Cells. 2013 Mar; 31(3):488-99. PMID: 23307570.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  32. Kaufmann KB, Brendel C, Suerth JD, Mueller-Kuller U, Chen-Wichmann L, Schwäble J, Pahujani S, Kunkel H, Schambach A, Baum C, Grez M. Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing. Mol Ther. 2013 Mar; 21(3):648-61. PMID: 23207695.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  33. Knight S, Zhang F, Mueller-Kuller U, Bokhoven M, Gupta A, Broughton T, Sha S, Antoniou MN, Brendel C, Grez M, Thrasher AJ, Collins M, Takeuchi Y. Safer, silencing-resistant lentiviral vectors: optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicing. J Virol. 2012 Sep; 86(17):9088-95. PMID: 22696657.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  34. Brendel C, Müller-Kuller U, Schultze-Strasser S, Stein S, Chen-Wichmann L, Krattenmacher A, Kunkel H, Dillmann A, Antoniou MN, Grez M. Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter. Gene Ther. 2012 Oct; 19(10):1018-29. PMID: 22071971.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  35. Santilli G, Almarza E, Brendel C, Choi U, Beilin C, Blundell MP, Haria S, Parsley KL, Kinnon C, Malech HL, Bueren JA, Grez M, Thrasher AJ. Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells. Mol Ther. 2011 Jan; 19(1):122-32. PMID: 20978475.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  36. Kimpel J, Braun SE, Qiu G, Wong FE, Conolle M, Schmitz JE, Brendel C, Humeau LM, Dropulic B, Rossi JJ, Berger A, von Laer D, Johnson RP. Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection. PLoS One. 2010 Aug 23; 5(8):e12357. PMID: 20808813.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  37. Vafaizadeh V, Klemmt P, Brendel C, Weber K, Doebele C, Britt K, Grez M, Fehse B, Desriviéres S, Groner B. Mammary epithelial reconstitution with gene-modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation. Stem Cells. 2010 May; 28(5):928-38. PMID: 20235097.
    Citations: 35     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.