Harvard Catalyst Profiles

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Alessio Fasano, M.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK104344 (FASANO, ALESSIO) Jun 15, 2016 - May 31, 2021
    Microbiome-derived Metabolites Linked to Celiac Disease Onset in Infants at Risk
    Role: Principal Investigator
  2. R34AT006945 (FASANO, ALESSIO) Sep 1, 2011 - Jun 30, 2014
    Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonates
    Role: Principal Investigator
  3. U19AI090873 (KAPER, JAMES B) Jul 20, 2010 - Jun 30, 2015
    Severe Enteric Disease: Pathogenesis and Response
    Role: Co-Principal Investigator
  4. U19AI082655 (SZTEIN, MARCELO B.) Jun 18, 2009 - May 31, 2019
    Mucusal and Systemic Immunity, Vaccines and Microbiota Interplay in Humans
    Role: Co-Principal Investigator
  5. R21DK078699 (FASANO, ALESSIO) Apr 15, 2008 - Mar 31, 2011
    Timing of Gluten Intake In Infant Nutrition and Risk of Celiac Disease Autoimmuni
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Valitutti F, Fasano A. Breaking Down Barriers: How Understanding Celiac Disease Pathogenesis Informed the Development of Novel Treatments. Dig Dis Sci. 2019 May 11. PMID: 31076989.
  2. Freire R, Ingano L, Serena G, Cetinbas M, Anselmo A, Sapone A, Sadreyev RI, Fasano A, Senger S. Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease. Sci Rep. 2019 May 07; 9(1):7029. PMID: 31065051.
  3. Leonard MM, Bai Y, Serena G, Nickerson KP, Camhi S, Sturgeon C, Yan S, Fiorentino MR, Katz A, Nath B, Richter J, Sleeman M, Gurer C, Fasano A. RNA sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis. PLoS One. 2019; 14(4):e0215132. PMID: 30998704.
  4. Shah NB, Allegretti AS, Nigwekar SU, Kalim S, Zhao S, Lelouvier B, Servant F, Serena G, Thadhani RI, Raj DS, Fasano A. Blood Microbiome Profile in CKD : A Pilot Study. Clin J Am Soc Nephrol. 2019 May 07; 14(5):692-701. PMID: 30962186.
  5. Llanos-Chea A, Citorik RJ, Nickerson KP, Ingano L, Serena G, Senger S, Lu TK, Fasano A, Faherty CS. Bacteriophage Therapy Testing Against Shigella flexneri in a Novel Human Intestinal Organoid-Derived Infection Model. J Pediatr Gastroenterol Nutr. 2019 Apr; 68(4):509-516. PMID: 30418409.
    Citations:    Fields:    
  6. Kelly DL, Demyanovich HK, Rodriguez KM, Ciháková D, Talor MV, McMahon RP, Richardson CM, Vyas G, Adams HA, August SM, Fasano A, Cascella NG, Feldman SM, Liu F, Sayer MA, Powell MM, Wehring HJ, Buchanan RW, Gold JM, Carpenter WT, Eaton WW. Randomized controlled trial of a gluten-free diet in patients with schizophrenia positive for antigliadin antibodies (AGA IgG): a pilot feasibility study J Psychiatry Neurosci. 2019 Mar 27; 44(3):1-9. PMID: 30938127.
  7. Camhi SS, Sangal K, Kenyon V, Lima R, Fasano A, Leonard MM. Pediatric Non-Celiac Gluten Sensitivity: A Gluten-Related Disorder Treatment Center Experience. J Pediatr Gastroenterol Nutr. 2019 Mar 18. PMID: 30908383.
  8. Leonard MM, Camhi S, Kenyon V, Betensky RA, Sturgeon C, Yan S, Fasano A. Targeted genotyping for the prediction of celiac disease autoimmunity development in patients with type 1 diabetes and their family members. World J Diabetes. 2019 Mar 15; 10(3):189-199. PMID: 30891154.
  9. De Santis S, Serino G, Fiorentino MR, Galleggiante V, Gena P, Verna G, Liso M, Massaro M, Lan J, Troisi J, Cataldo I, Bertamino A, Pinto A, Campiglia P, Santino A, Giannelli G, Fasano A, Calamita G, Chieppa M. Corrigendum: Aquaporin-9 Contributes to the Maturation Process and Inflammatory Cytokine Secretion of Murine Dendritic Cells. Front Immunol. 2019; 10:216. PMID: 30873153.
  10. Emberti Gialloreti L, Mazzone L, Benvenuto A, Fasano A, Alcon AG, Kraneveld A, Moavero R, Raz R, Riccio MP, Siracusano M, Zachor DA, Marini M, Curatolo P. Risk and Protective Environmental Factors Associated with Autism Spectrum Disorder: Evidence-Based Principles and Recommendations. J Clin Med. 2019 Feb 08; 8(2). PMID: 30744008.
  11. Serena G, Fasano A. Use of Probiotics to Prevent Celiac Disease and IBD in Pediatrics. Adv Exp Med Biol. 2018 Dec 20. PMID: 30565165.
    Citations:    Fields:    
  12. Serena G, Kelly CP, Fasano A. Nondietary Therapies for Celiac Disease. Gastroenterol Clin North Am. 2019 03; 48(1):145-163. PMID: 30711207.
  13. Scheffler L, Kovacs P, Fasano A, Heiker JT. Letter to the Editor regarding Mörkl et al.'s paper: Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women. Eur J Nutr. 2018 Dec; 57(8):2999-3000. PMID: 30291419.
    Citations:    Fields:    
  14. Ma B, McComb E, Gajer P, Yang H, Humphrys M, Okogbule-Wonodi AC, Fasano A, Ravel J, Viscardi RM. Microbial Biomarkers of Intestinal Barrier Maturation in Preterm Infants. Front Microbiol. 2018; 9:2755. PMID: 30487786.
  15. Salerno-Gonçalves R, Galen JE, Levine MM, Fasano A, Sztein MB. Manipulation of Salmonella Typhi Gene Expression Impacts Innate Cell Responses in the Human Intestinal Mucosa. Front Immunol. 2018; 9:2543. PMID: 30443257.
  16. De Santis S, Serino G, Fiorentino MR, Galleggiante V, Gena P, Verna G, Liso M, Massaro M, Lan J, Troisi J, Cataldo I, Bertamino A, Pinto A, Campiglia P, Santino A, Giannelli G, Fasano A, Calamita G, Chieppa M. Aquaporin 9 Contributes to the Maturation Process and Inflammatory Cytokine Secretion of Murine Dendritic Cells. Front Immunol. 2018; 9:2355. PMID: 30386332.
  17. Llanos-Chea A, Fasano A. Gluten and Functional Abdominal Pain Disorders in Children. Nutrients. 2018 Oct 12; 10(10). PMID: 30322070.
    Citations:    Fields:    Translation:HumansAnimals
  18. Gora MJ, Quénéhervé L, Carruth RW, Lu W, Rosenberg M, Sauk JS, Fasano A, Lauwers GY, Nishioka NS, Tearney GJ. Tethered capsule endomicroscopy for microscopic imaging of the esophagus, stomach, and duodenum without sedation in humans (with video). Gastrointest Endosc. 2018 11; 88(5):830-840.e3. PMID: 30031805.
    Citations:    Fields:    
  19. Zhang Y, Brady A, Jones C, Song Y, Darton TC, Jones C, Blohmke CJ, Pollard AJ, Magder LS, Fasano A, Sztein MB, Fraser CM. Compositional and Functional Differences in the Human Gut Microbiome Correlate with Clinical Outcome following Infection with Wild-Type Salmonella enterica Serovar Typhi. MBio. 2018 05 08; 9(3). PMID: 29739901.
    Citations:    Fields:    Translation:HumansCells
  20. Rotondi Aufiero V, Fasano A, Mazzarella G. Non-Celiac Gluten Sensitivity: How Its Gut Immune Activation and Potential Dietary Management Differ from Celiac Disease. Mol Nutr Food Res. 2018 05; 62(9):e1700854. PMID: 29578652.
    Citations:    Fields:    Translation:HumansAnimalsCells
  21. Rose DR, Yang H, Serena G, Sturgeon C, Ma B, Careaga M, Hughes HK, Angkustsiri K, Rose M, Hertz-Picciotto I, Van de Water J, Hansen RL, Ravel J, Fasano A, Ashwood P. Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms. Brain Behav Immun. 2018 05; 70:354-368. PMID: 29571898.
    Citations: 3     Fields:    
  22. Leon J, Pérez-Sáez MJ, Uffing A, Murakami N, Watanabe A, Cureton P, Kenyon V, Keating L, Yee K, Fernandes Satiro CA, Yu B, Bonventre JV, Fasano A, Riella LV. Effect of Combined Gluten-Free, Dairy-Free Diet in Children With Steroid-Resistant Nephrotic Syndrome: An Open Pilot Trial. Kidney Int Rep. 2018 Jul; 3(4):851-860. PMID: 30116795.
  23. Scheffler L, Crane A, Heyne H, Tönjes A, Schleinitz D, Ihling CH, Stumvoll M, Freire R, Fiorentino M, Fasano A, Kovacs P, Heiker JT. Widely Used Commercial ELISA Does Not Detect Precursor of Haptoglobin2, but Recognizes Properdin as a Potential Second Member of the Zonulin Family. Front Endocrinol (Lausanne). 2018; 9:22. PMID: 29459849.
    Citations: 2     
  24. Senger S, Ingano L, Freire R, Anselmo A, Zhu W, Sadreyev R, Walker WA, Fasano A. Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC). Cell Mol Gastroenterol Hepatol. 2018; 5(4):549-568. PMID: 29930978.
    Citations: 1     
  25. Vavricka SR, Stelzer T, Lattmann J, Stotz M, Lehmann R, Zeitz J, Scharl M, Misselwitz B, Pohl D, Fried M, Tutuian R, Fasano A, Schoepfer AM, Rogler G, Biedermann L, Greuter T. Celiac Disease is Misdiagnosed Based on Serology Only in a Substantial Proportion of Patients. J Clin Gastroenterol. 2018 Jan; 52(1):25-29. PMID: 27636410.
    Citations: 1     Fields:    Translation:Humans
  26. Catassi C, Alaedini A, Bojarski C, Bonaz B, Bouma G, Carroccio A, Castillejo G, De Magistris L, Dieterich W, Di Liberto D, Elli L, Fasano A, Hadjivassiliou M, Kurien M, Lionetti E, Mulder CJ, Rostami K, Sapone A, Scherf K, Schuppan D, Trott N, Volta U, Zevallos V, Zopf Y, Sanders DS. The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update. Nutrients. 2017 Nov 21; 9(11). PMID: 29160841.
    Citations: 4     Fields:    Translation:Humans
  27. Fasano A. Another reason to favor exclusive breastfeeding: microbiome resilience. J Pediatr (Rio J). 2018 May - Jun; 94(3):224-225. PMID: 29111201.
    Citations: 1     Fields:    Translation:Humans
  28. Kelly DL, Demyanovich HK, Eaton WW, Cascella N, Jackson J, Fasano A, Carpenter WT. Anti gliadin antibodies (AGA IgG) related to peripheral inflammation in schizophrenia. Brain Behav Immun. 2018 03; 69:57-59. PMID: 29074356.
    Citations:    Fields:    
  29. Leonard MM, Cureton P, Fasano A. Indications and Use of the Gluten Contamination Elimination Diet for Patients with Non-Responsive Celiac Disease. Nutrients. 2017 Oct 18; 9(10). PMID: 29057833.
    Citations:    Fields:    Translation:Humans
  30. Leonard MM, Fasano A. Zero, One, or Two Endoscopies to Diagnose and Monitor Pediatric Celiac Disease? The Jury Is Still Out. J Pediatr Gastroenterol Nutr. 2017 09; 65(3):270-271. PMID: 28829342.
    Citations:    Fields:    Translation:Humans
  31. Booth JS, Patil SA, Ghazi L, Barnes R, Fraser CM, Fasano A, Greenwald BD, Sztein MB. Systemic and Terminal Ileum Mucosal Immunity Elicited by Oral Immunization With the Ty21a Typhoid Vaccine in Humans. Cell Mol Gastroenterol Hepatol. 2017 Nov; 4(3):419-437. PMID: 29022005.
    Citations: 1     
  32. Leonard MM, Sapone A, Catassi C, Fasano A. Celiac Disease and Nonceliac Gluten Sensitivity: A Review. JAMA. 2017 Aug 15; 318(7):647-656. PMID: 28810029.
    Citations: 6     Fields:    Translation:Humans
  33. Fasano A, Hill I. Serum Zonulin, Gut Permeability, and the Pathogenesis of Autism Spectrum Disorders: Cause, Effect, or an Epiphenomenon? J Pediatr. 2017 09; 188:15-17. PMID: 28624097.
    Citations: 1     Fields:    Translation:Humans
  34. Xian L, Georgess D, Huso T, Cope L, Belton A, Chang YT, Kuang W, Gu Q, Zhang X, Senger S, Fasano A, Huso DL, Ewald AJ, Resar LMS. HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche. Nat Commun. 2017 04 28; 8:15008. PMID: 28452345.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  35. Sturgeon C, Lan J, Fasano A. Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model. Ann N Y Acad Sci. 2017 06; 1397(1):130-142. PMID: 28423466.
    Citations: 2     Fields:    Translation:Animals
  36. Fasano A. Celiac Disease, Gut-Brain Axis, and Behavior: Cause, Consequence, or Merely Epiphenomenon? Pediatrics. 2017 03; 139(3). PMID: 28219968.
    Citations:    Fields:    Translation:Humans
  37. Leonard MM, Weir DC, DeGroote M, Mitchell PD, Singh P, Silvester JA, Leichtner AM, Fasano A. Value of IgA tTG in Predicting Mucosal Recovery in Children With Celiac Disease on a Gluten-Free Diet. J Pediatr Gastroenterol Nutr. 2017 02; 64(2):286-291. PMID: 28112686.
    Citations: 3     Fields:    Translation:Humans
  38. Saleem B, Okogbule-Wonodi AC, Fasano A, Magder LS, Ravel J, Kapoor S, Viscardi RM. Intestinal Barrier Maturation in Very Low Birthweight Infants: Relationship to Feeding and Antibiotic Exposure. J Pediatr. 2017 04; 183:31-36.e1. PMID: 28159311.
    Citations: 2     Fields:    Translation:Humans
  39. Kang DW, Adams JB, Gregory AC, Borody T, Chittick L, Fasano A, Khoruts A, Geis E, Maldonado J, McDonough-Means S, Pollard EL, Roux S, Sadowsky MJ, Lipson KS, Sullivan MB, Caporaso JG, Krajmalnik-Brown R. Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome. 2017 01 23; 5(1):10. PMID: 28122648.
    Citations: 40     Fields:    Translation:HumansCellsCTClinical Trials
  40. Serena G, Yan S, Camhi S, Patel S, Lima RS, Sapone A, Leonard MM, Mukherjee R, Nath BJ, Lammers KM, Fasano A. Proinflammatory cytokine interferon-? and microbiome-derived metabolites dictate epigenetic switch between forkhead box protein 3 isoforms in coeliac disease. Clin Exp Immunol. 2017 03; 187(3):490-506. PMID: 27936497.
    Citations: 4     Fields:    Translation:HumansCells
  41. Ciccia F, Guggino G, Rizzo A, Alessandro R, Luchetti MM, Milling S, Saieva L, Cypers H, Stampone T, Di Benedetto P, Gabrielli A, Fasano A, Elewaut D, Triolo G. Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis. Ann Rheum Dis. 2017 Jun; 76(6):1123-1132. PMID: 28069576.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  42. Fasano A. Gut permeability, obesity, and metabolic disorders: who is the chicken and who is the egg? Am J Clin Nutr. 2017 01; 105(1):3-4. PMID: 28003208.
    Citations:    Fields:    Translation:Animals
  43. Greuter T, Schmidlin S, Lattmann J, Stotz M, Lehmann R, Zeitz J, Scharl M, Misselwitz B, Pohl D, Fried M, Tutuian R, Fasano A, Schoepfer AM, Rogler G, Biedermann L, Vavricka SR. The perspective of celiac disease patients on emerging treatment options and non-celiac gluten sensitivity. Dig Liver Dis. 2017 Mar; 49(3):268-272. PMID: 28034662.
    Citations:    Fields:    Translation:Humans
  44. Catassi C, Fasano A. Tempters and Gluten-Free Diet. Nutrients. 2016 Dec 03; 8(12). PMID: 27918479.
    Citations:    Fields:    Translation:Humans
  45. Fiorentino M, Sapone A, Senger S, Camhi SS, Kadzielski SM, Buie TM, Kelly DL, Cascella N, Fasano A. Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders. Mol Autism. 2016; 7:49. PMID: 27957319.
    Citations: 13     Fields:    Translation:HumansCells
  46. Sturgeon C, Fasano A. Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases. Tissue Barriers. 2016; 4(4):e1251384. PMID: 28123927.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  47. Guerrant RL, Leite AM, Pinkerton R, Medeiros PH, Cavalcante PA, DeBoer M, Kosek M, Duggan C, Gewirtz A, Kagan JC, Gauthier AE, Swann J, Mayneris-Perxachs J, Bolick DT, Maier EA, Guedes MM, Moore SR, Petri WA, Havt A, Lima IF, Prata MM, Michaleckyj JC, Scharf RJ, Sturgeon C, Fasano A, Lima AA. Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil. PLoS One. 2016; 11(9):e0158772. PMID: 27690129.
    Citations: 29     Fields:    
  48. Faherty CS, Wu T, Morris CR, Grassel CL, Rasko DA, Harper JM, Shea-Donohue T, Fasano A, Barry EM. The synthesis of OspD3 (ShET2) in Shigella flexneri is independent of OspC1. Gut Microbes. 2016 11; 7(6):486-502. PMID: 27657187.
    Citations: 2     Fields:    Translation:HumansCells
  49. Martin VJ, Leonard MM, Fiechtner L, Fasano A. Transitioning From Descriptive to Mechanistic Understanding of the Microbiome: The Need for a Prospective Longitudinal Approach to Predicting Disease. J Pediatr. 2016 12; 179:240-248. PMID: 27634626.
    Citations: 2     Fields:    Translation:Humans
  50. Delichatsios H, Fasano A. Case 14-2016: A Woman with a Thyroid Nodule and Psychosis. N Engl J Med. 2016 09 01; 375(9):e20. PMID: 27579661.
    Citations:    Fields:    Translation:Humans
  51. Snyder J, Butzner JD, DeFelice AR, Fasano A, Guandalini S, Liu E, Newton KP. Evidence-Informed Expert Recommendations for the Management of Celiac Disease in Children. Pediatrics. 2016 09; 138(3). PMID: 27565547.
    Citations: 6     Fields:    Translation:Humans
  52. Salerno-Goncalves R, Fasano A, Sztein MB. Development of a Multicellular Three-dimensional Organotypic Model of the Human Intestinal Mucosa Grown Under Microgravity. J Vis Exp. 2016 07 25; (113). PMID: 27500889.
    Citations: 3     Fields:    Translation:HumansCells
  53. Hill ID, Fasano A, Guandalini S, Hoffenberg E, Levy J, Reilly N, Verma R. NASPGHAN Clinical Report on the Diagnosis and Treatment of Gluten-related Disorders. J Pediatr Gastroenterol Nutr. 2016 07; 63(1):156-65. PMID: 27035374.
    Citations: 7     Fields:    Translation:Humans
  54. Vavricka SR, Vadasz N, Stotz M, Lehmann R, Studerus D, Greuter T, Frei P, Zeitz J, Scharl M, Misselwitz B, Pohl D, Fried M, Tutuian R, Fasano A, Schoepfer AM, Rogler G, Biedermann L. Celiac disease diagnosis still significantly delayed - Doctor's but not patients' delay responsive for the increased total delay in women. Dig Liver Dis. 2016 Oct; 48(10):1148-54. PMID: 27401607.
    Citations: 2     Fields:    Translation:Humans
  55. Lee J, Greenspan PT, Israel E, Katz A, Fasano A, Kaafarani HM, Linov PL, Raja AS, Rao SK. Emergency Department Utilization Report to Decrease Visits by Pediatric Gastroenterology Patients. Pediatrics. 2016 07; 138(1). PMID: 27287727.
    Citations:    Fields:    Translation:Humans
  56. Serena G, Leonard MM, Camhi S, Huedo-Medina TB, Fasano A. [Design of a genomic, environmental, microbial and metabolomic study on celiac disease: an approach to the future of personalized prevention of celiac disease]. Recenti Prog Med. 2016 Jun; 107(6):320-7. PMID: 27362724.
    Citations:    Fields:    Translation:Humans
  57. Shea-Donohue T, Fasano A, Zhao A, Notari L, Yan S, Sun R, Bohl JA, Desai N, Tudor G, Morimoto M, Booth C, Bennett A, Farese AM, MacVittie TJ. Mechanisms Involved in the Development of the Chronic Gastrointestinal Syndrome in Nonhuman Primates after Total-Body Irradiation with Bone Marrow Shielding. Radiat Res. 2016 06; 185(6):591-603. PMID: 27223826.
    Citations: 3     Fields:    Translation:AnimalsPHPublic Health
  58. Delichatsios HK, Leonard MM, Fasano A, Nosé V. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 14-2016. A 37-Year-Old Woman with Adult-Onset Psychosis. N Engl J Med. 2016 May 12; 374(19):1875-83. PMID: 27168437.
    Citations:    Fields:    Translation:Humans
  59. Leonard MM, Fasano A. The microbiome as a possible target to prevent celiac disease. Expert Rev Gastroenterol Hepatol. 2016; 10(5):555-6. PMID: 26999627.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  60. Fasano A. Gut microbiome and necrotising enterocolitis: time for intervention? Lancet. 2016 May 07; 387(10031):1884-5. PMID: 26969092.
    Citations:    Fields:    Translation:Humans
  61. Senger S, Sapone A, Fiorentino MR, Mazzarella G, Lauwers GY, Fasano A. Celiac Disease Histopathology Recapitulates Hedgehog Downregulation, Consistent with Wound Healing Processes Activation. PLoS One. 2015; 10(12):e0144634. PMID: 26649570.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  62. Leonard MM, Camhi S, Huedo-Medina TB, Fasano A. Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CDGEMM) Study Design: Approach to the Future of Personalized Prevention of Celiac Disease. Nutrients. 2015 Nov 11; 7(11):9325-36. PMID: 26569299.
    Citations: 6     Fields:    Translation:Humans
  63. Lammers KM, Chieppa M, Liu L, Liu S, Omatsu T, Janka-Junttila M, Casolaro V, Reinecker HC, Parent CA, Fasano A. Gliadin Induces Neutrophil Migration via Engagement of the Formyl Peptide Receptor, FPR1. PLoS One. 2015; 10(9):e0138338. PMID: 26378785.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  64. Serena G, Camhi S, Sturgeon C, Yan S, Fasano A. The Role of Gluten in Celiac Disease and Type 1 Diabetes. Nutrients. 2015 Aug 26; 7(9):7143-62. PMID: 26343710.
    Citations: 6     Fields:    Translation:HumansAnimals
  65. Leffler DA, Green PH, Fasano A. Extraintestinal manifestations of coeliac disease. Nat Rev Gastroenterol Hepatol. 2015 Oct; 12(10):561-71. PMID: 26260366.
    Citations: 22     Fields:    Translation:Humans
  66. Lebwohl B, Murray JA, Verdú EF, Crowe SE, Dennis M, Fasano A, Green PH, Guandalini S, Khosla C. Gluten Introduction, Breastfeeding, and Celiac Disease: Back to the Drawing Board. Am J Gastroenterol. 2016 Jan; 111(1):12-4. PMID: 26259710.
    Citations: 3     Fields:    Translation:Humans
  67. Catassi C, Elli L, Bonaz B, Bouma G, Carroccio A, Castillejo G, Cellier C, Cristofori F, de Magistris L, Dolinsek J, Dieterich W, Francavilla R, Hadjivassiliou M, Holtmeier W, Körner U, Leffler DA, Lundin KE, Mazzarella G, Mulder CJ, Pellegrini N, Rostami K, Sanders D, Skodje GI, Schuppan D, Ullrich R, Volta U, Williams M, Zevallos VF, Zopf Y, Fasano A. Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts' Criteria. Nutrients. 2015 Jun 18; 7(6):4966-77. PMID: 26096570.
    Citations: 45     Fields:    Translation:Humans
  68. Hollon J, Puppa EL, Greenwald B, Goldberg E, Guerrerio A, Fasano A. Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Nutrients. 2015 Feb 27; 7(3):1565-76. PMID: 25734566.
    Citations: 18     Fields:    Translation:HumansCells
  69. Rawal N, Twaddell W, Fasano A, Blanchard S, Safta A. Remission of Refractory Celiac Disease With Infliximab in a Pediatric Patient. ACG Case Rep J. 2015 Jan; 2(2):121-3. PMID: 26157934.
    Citations: 3     
  70. Fasano A, Sapone A, Zevallos V, Schuppan D. Nonceliac gluten sensitivity. Gastroenterology. 2015 May; 148(6):1195-204. PMID: 25583468.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  71. Lauwers GY, Fasano A, Brown IS. Duodenal lymphocytosis with no or minimal enteropathy: much ado about nothing? Mod Pathol. 2015 Jan; 28 Suppl 1:S22-9. PMID: 25560597.
    Citations: 3     Fields:    Translation:Humans
  72. Jackson J, Eaton W, Cascella N, Fasano A, Santora D, Sullivan K, Feldman S, Raley H, McMahon RP, Carpenter WT, Demyanovich H, Kelly DL. Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia. Schizophr Res. 2014 Nov; 159(2-3):539-42. PMID: 25311778.
    Citations: 8     Fields:    Translation:Humans
  73. Leonard MM, Serena G, Sturgeon C, Fasano A. Genetics and celiac disease: the importance of screening. Expert Rev Gastroenterol Hepatol. 2015 Feb; 9(2):209-15. PMID: 25294637.
    Citations: 1     Fields:    Translation:Humans
  74. Lionetti E, Castellaneta S, Francavilla R, Pulvirenti A, Tonutti E, Amarri S, Barbato M, Barbera C, Barera G, Bellantoni A, Castellano E, Guariso G, Limongelli MG, Pellegrino S, Polloni C, Ughi C, Zuin G, Fasano A, Catassi C. Introduction of gluten, HLA status, and the risk of celiac disease in children. N Engl J Med. 2014 Oct 02; 371(14):1295-303. PMID: 25271602.
    Citations: 63     Fields:    Translation:Humans
  75. Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM, Mani S. Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity. 2014 Aug 21; 41(2):296-310. PMID: 25065623.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  76. Catassi C, Fasano A. Coeliac disease. The debate on coeliac disease screening--are we there yet? Nat Rev Gastroenterol Hepatol. 2014 Aug; 11(8):457-8. PMID: 25001972.
    Citations: 6     Fields:    Translation:Humans
  77. Garner C, Ahn R, Ding YC, Steele L, Stoven S, Green PH, Fasano A, Murray JA, Neuhausen SL. Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus. PLoS One. 2014; 9(7):e101428. PMID: 24999842.
    Citations: 15     Fields:    Translation:Humans
  78. Shamir R, Heyman MB, Koning F, Wijmenga C, Wijimenga C, Gutierrez-Achury J, Catassi C, Gatti S, Fasano A, Discepolo V, Korponay-Szabó IR, Zevit N, Maki M, Schaart MW, Mearin ML, Troncone R. Celiac disease: past, present, and future challenges: dedicated to the memory of our friend and colleague, Prof David Branski (1944-2013). J Pediatr Gastroenterol Nutr. 2014 Jul; 59 Suppl 1:S1-20. PMID: 24840514.
    Citations: 1     Fields:    Translation:Humans
  79. Catassi C, Gatti S, Fasano A. The new epidemiology of celiac disease. J Pediatr Gastroenterol Nutr. 2014 Jul; 59 Suppl 1:S7-9. PMID: 24979197.
    Citations: 19     Fields:    Translation:Humans
  80. Lakos G, Norman GL, Mahler M, Martis P, Bentow C, Santora D, Fasano A. Analytical and clinical comparison of two fully automated immunoassay systems for the diagnosis of celiac disease. J Immunol Res. 2014; 2014:371263. PMID: 24741592.
    Citations: 4     Fields:    Translation:Humans
  81. Barada K, Habib RH, Malli A, Hashash JG, Halawi H, Maasri K, Tawil A, Mourad F, Sharara AI, Soweid A, Sukkarieh I, Chakhachiro Z, Jabbour M, Fasano A, Santora D, Arguelles C, Murray JA, Green PH. Prediction of celiac disease at endoscopy. Endoscopy. 2014 Feb; 46(2):110-9. PMID: 24477366.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  82. Fiorentino M, Levine MM, Sztein MB, Fasano A. Effect of wild-type Shigella species and attenuated Shigella vaccine candidates on small intestinal barrier function, antigen trafficking, and cytokine release. PLoS One. 2014; 9(1):e85211. PMID: 24416363.
    Citations: 6     Fields:    Translation:HumansCells
  83. Siniscalco D, Sapone A, Giordano C, Cirillo A, de Magistris L, Rossi F, Fasano A, Bradstreet JJ, Maione S, Antonucci N. Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders. J Autism Dev Disord. 2013 Nov; 43(11):2686-95. PMID: 23585028.
    Citations: 20     Fields:    Translation:HumansCells
  84. Catassi C, Bai JC, Bonaz B, Bouma G, Calabrò A, Carroccio A, Castillejo G, Ciacci C, Cristofori F, Dolinsek J, Francavilla R, Elli L, Green P, Holtmeier W, Koehler P, Koletzko S, Meinhold C, Sanders D, Schumann M, Schuppan D, Ullrich R, Vécsei A, Volta U, Zevallos V, Sapone A, Fasano A. Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders. Nutrients. 2013 Sep 26; 5(10):3839-53. PMID: 24077239.
    Citations: 71     Fields:    Translation:Humans
  85. de Magistris L, Picardi A, Siniscalco D, Riccio MP, Sapone A, Cariello R, Abbadessa S, Medici N, Lammers KM, Schiraldi C, Iardino P, Marotta R, Tolone C, Fasano A, Pascotto A, Bravaccio C. Antibodies against food antigens in patients with autistic spectrum disorders. Biomed Res Int. 2013; 2013:729349. PMID: 23984403.
    Citations: 12     Fields:    Translation:Humans
  86. Vajro P, Paolella G, Fasano A. Microbiota and gut-liver axis: their influences on obesity and obesity-related liver disease. J Pediatr Gastroenterol Nutr. 2013 May; 56(5):461-8. PMID: 23287807.
    Citations: 34     Fields:    Translation:HumansAnimals
  87. Alaish SM, Smith AD, Timmons J, Greenspon J, Eyvazzadeh D, Murphy E, Shea-Donahue T, Cirimotich S, Mongodin E, Zhao A, Fasano A, Nataro JP, Cross A. Gut microbiota, tight junction protein expression, intestinal resistance, bacterial translocation and mortality following cholestasis depend on the genetic background of the host. Gut Microbes. 2013 Jul-Aug; 4(4):292-305. PMID: 23652772.
    Citations: 9     Fields:    Translation:Animals
  88. Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang MS, Grailer JJ, Zetoune FS, Andjelkovic AV, Fasano A, Ward PA. Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15; 304(12):L863-72. PMID: 23564505.
    Citations: 12     Fields:    Translation:AnimalsCells
  89. Hollon JR, Cureton PA, Martin ML, Puppa EL, Fasano A. Trace gluten contamination may play a role in mucosal and clinical recovery in a subgroup of diet-adherent non-responsive celiac disease patients. BMC Gastroenterol. 2013 Feb 28; 13:40. PMID: 23448408.
    Citations: 15     Fields:    Translation:HumansCellsPHPublic Health
  90. Barry EM, Pasetti MF, Sztein MB, Fasano A, Kotloff KL, Levine MM. Progress and pitfalls in Shigella vaccine research. Nat Rev Gastroenterol Hepatol. 2013 Apr; 10(4):245-55. PMID: 23419287.
    Citations: 29     Fields:    Translation:HumansCells
  91. Fiorentino M, Lammers KM, Levine MM, Sztein MB, Fasano A. In vitro Intestinal Mucosal Epithelial Responses to Wild-Type Salmonella Typhi and Attenuated Typhoid Vaccines. Front Immunol. 2013; 4:17. PMID: 23408152.
    Citations: 4     
  92. Bai JC, Fried M, Corazza GR, Schuppan D, Farthing M, Catassi C, Greco L, Cohen H, Ciacci C, Eliakim R, Fasano A, González A, Krabshuis JH, LeMair A. World Gastroenterology Organisation global guidelines on celiac disease. J Clin Gastroenterol. 2013 Feb; 47(2):121-6. PMID: 23314668.
    Citations: 43     Fields:    Translation:Humans
  93. Fiorentino M, Ding H, Blanchard TG, Czinn SJ, Sztein MB, Fasano A. Helicobacter pylori-induced disruption of monolayer permeability and proinflammatory cytokine secretion in polarized human gastric epithelial cells. Infect Immun. 2013 Mar; 81(3):876-83. PMID: 23297384.
    Citations: 16     Fields:    Translation:HumansCells
  94. Fasano A, Catassi C. Clinical practice. Celiac disease. N Engl J Med. 2012 Dec 20; 367(25):2419-26. PMID: 23252527.
    Citations: 102     Fields:    Translation:Humans
  95. Fabbri P, Calabrò AS, Hashimoto T, Fasano A, Caproni M. Novel advances in dermatitis herpetiformis. Clin Dev Immunol. 2012; 2012:450109. PMID: 23316253.
    Citations:    Fields:    Translation:Humans
  96. Gibert A, Kruizinga AG, Neuhold S, Houben GF, Canela MA, Fasano A, Catassi C. Might gluten traces in wheat substitutes pose a risk in patients with celiac disease? A population-based probabilistic approach to risk estimation. Am J Clin Nutr. 2013 Jan; 97(1):109-16. PMID: 23193005.
    Citations: 8     Fields:    Translation:HumansAnimals
  97. Faherty CS, Faherty C, Harper JM, Shea-Donohue T, Barry EM, Kaper JB, Fasano A, Nataro JP. Chromosomal and plasmid-encoded factors of Shigella flexneri induce secretogenic activity ex vivo. PLoS One. 2012; 7(11):e49980. PMID: 23166804.
    Citations: 7     Fields:    Translation:AnimalsCells
  98. Coury DL, Ashwood P, Fasano A, Fuchs G, Geraghty M, Kaul A, Mawe G, Patterson P, Jones NE. Gastrointestinal conditions in children with autism spectrum disorder: developing a research agenda. Pediatrics. 2012 Nov; 130 Suppl 2:S160-8. PMID: 23118247.
    Citations: 34     Fields:    Translation:HumansAnimals
  99. Fasano A. Novel therapeutic/integrative approaches for celiac disease and dermatitis herpetiformis. Clin Dev Immunol. 2012; 2012:959061. PMID: 23093980.
    Citations: 7     Fields:    Translation:HumansAnimals
  100. Fasano A. Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clin Gastroenterol Hepatol. 2012 Oct; 10(10):1096-100. PMID: 22902773.
    Citations: 28     Fields:    Translation:HumansCells
  101. Vanuytsel T, Senger S, Fasano A, Shea-Donohue T. Major signaling pathways in intestinal stem cells. Biochim Biophys Acta. 2013 Feb; 1830(2):2410-26. PMID: 22922290.
    Citations: 8     Fields:    Translation:AnimalsCells
  102. Reilly NR, Fasano A, Green PH. Presentation of celiac disease. Gastrointest Endosc Clin N Am. 2012 Oct; 22(4):613-21. PMID: 23083982.
    Citations: 13     Fields:    Translation:Humans
  103. Jackson J, Eaton W, Cascella N, Fasano A, Warfel D, Feldman S, Richardson C, Vyas G, Linthicum J, Santora D, Warren KR, Carpenter WT, Kelly DL. A gluten-free diet in people with schizophrenia and anti-tissue transglutaminase or anti-gliadin antibodies. Schizophr Res. 2012 Sep; 140(1-3):262-3. PMID: 22771303.
    Citations: 14     Fields:    Translation:Humans
  104. Siniscalco D, Sapone A, Giordano C, Cirillo A, de Novellis V, de Magistris L, Rossi F, Fasano A, Maione S, Antonucci N. The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patients. J Autism Dev Disord. 2012 Jul; 42(7):1403-10. PMID: 21969075.
    Citations: 19     Fields:    Translation:HumansCells
  105. Fasano A. Zonulin, regulation of tight junctions, and autoimmune diseases. Ann N Y Acad Sci. 2012 Jul; 1258:25-33. PMID: 22731712.
    Citations: 30     Fields:    Translation:HumansCells
  106. Lionetti E, Castellaneta S, Pulvirenti A, Tonutti E, Francavilla R, Fasano A, Catassi C. Prevalence and natural history of potential celiac disease in at-family-risk infants prospectively investigated from birth. J Pediatr. 2012 Nov; 161(5):908-14. PMID: 22704250.
    Citations: 7     Fields:    Translation:Humans
  107. Ahn R, Ding YC, Murray J, Fasano A, Green PH, Neuhausen SL, Garner C. Association analysis of the extended MHC region in celiac disease implicates multiple independent susceptibility loci. PLoS One. 2012; 7(5):e36926. PMID: 22615847.
    Citations: 14     Fields:    Translation:Humans
  108. Ludvigsson JF, Fasano A. Timing of introduction of gluten and celiac disease risk. Ann Nutr Metab. 2012; 60 Suppl 2:22-9. PMID: 22555186.
    Citations: 9     Fields:    Translation:Humans
  109. Cascella NG, Santora D, Gregory P, Kelly DL, Fasano A, Eaton WW. Increased prevalence of transglutaminase 6 antibodies in sera from schizophrenia patients. Schizophr Bull. 2013 Jul; 39(4):867-71. PMID: 22516148.
    Citations: 14     Fields:    Translation:Humans
  110. Rossi F, Bellini G, Tolone C, Luongo L, Mancusi S, Papparella A, Sturgeon C, Fasano A, Nobili B, Perrone L, Maione S, del Giudice EM. The cannabinoid receptor type 2 Q63R variant increases the risk of celiac disease: implication for a novel molecular biomarker and future therapeutic intervention. Pharmacol Res. 2012 Jul; 66(1):88-94. PMID: 22465144.
    Citations: 10     Fields:    Translation:Humans
  111. Sellitto M, Bai G, Serena G, Fricke WF, Sturgeon C, Gajer P, White JR, Koenig SS, Sakamoto J, Boothe D, Gicquelais R, Kryszak D, Puppa E, Catassi C, Ravel J, Fasano A. Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants. PLoS One. 2012; 7(3):e33387. PMID: 22432018.
    Citations: 60     Fields:    Translation:HumansCellsPHPublic Health
  112. Jackson JR, Eaton WW, Cascella NG, Fasano A, Kelly DL. Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity. Psychiatr Q. 2012 Mar; 83(1):91-102. PMID: 21877216.
    Citations: 34     Fields:    Translation:HumansAnimals
  113. Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C. The Oslo definitions for coeliac disease and related terms. Gut. 2013 Jan; 62(1):43-52. PMID: 22345659.
    Citations: 224     Fields:    Translation:Humans
  114. Sapone A, Bai JC, Ciacci C, Dolinsek J, Green PH, Hadjivassiliou M, Kaukinen K, Rostami K, Sanders DS, Schumann M, Ullrich R, Villalta D, Volta U, Catassi C, Fasano A. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med. 2012 Feb 07; 10:13. PMID: 22313950.
    Citations: 150     Fields:    Translation:HumansCells
  115. Fasano A. Leaky gut and autoimmune diseases. Clin Rev Allergy Immunol. 2012 Feb; 42(1):71-8. PMID: 22109896.
    Citations: 44     Fields:    Translation:HumansAnimals
  116. Nair PP, Kamra A, Kessie G, Kalavapudi S, Chen JH, Shores R, Madairos L, Fasano A, Nair P. Markers of Inflammation and Lineage on Exfoliated Colonic Cells In Pediatric Inflammatory Bowel Disease. J Gastrointest Dig Syst. 2011 Dec 16; 8(1):1-6. PMID: 23519721.
  117. Netzel-Arnett S, Buzza MS, Shea-Donohue T, Désilets A, Leduc R, Fasano A, Bugge TH, Antalis TM. Matriptase protects against experimental colitis and promotes intestinal barrier recovery. Inflamm Bowel Dis. 2012 Jul; 18(7):1303-14. PMID: 22081509.
    Citations: 17     Fields:    Translation:HumansAnimals
  118. Fasano A, Catassi C. Early feeding practices and their impact on development of celiac disease. Nestle Nutr Workshop Ser Pediatr Program. 2011; 68:201-9; discussion 210-3. PMID: 22044901.
    Citations: 2     Fields:    Translation:Humans
  119. Silva MA, Jury J, Sanz Y, Wiepjes M, Huang X, Murray JA, David CS, Fasano A, Verdú EF. Increased bacterial translocation in gluten-sensitive mice is independent of small intestinal paracellular permeability defect. Dig Dis Sci. 2012 Jan; 57(1):38-47. PMID: 21822909.
    Citations: 7     Fields:    Translation:AnimalsCells
  120. Salerno-Goncalves R, Fasano A, Sztein MB. Engineering of a multicellular organotypic model of the human intestinal mucosa. Gastroenterology. 2011 Aug; 141(2):e18-20. PMID: 21723866.
    Citations: 11     Fields:    Translation:HumansCells
  121. Sapone A, Lammers KM, Casolaro V, Cammarota M, Giuliano MT, De Rosa M, Stefanile R, Mazzarella G, Tolone C, Russo MI, Esposito P, Ferraraccio F, Cartenì M, Riegler G, de Magistris L, Fasano A. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med. 2011 Mar 09; 9:23. PMID: 21392369.
    Citations: 87     Fields:    Translation:Humans
  122. Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev. 2011 Jan; 91(1):151-75. PMID: 21248165.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  123. Lammers KM, Khandelwal S, Chaudhry F, Kryszak D, Puppa EL, Casolaro V, Fasano A. Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease. Immunology. 2011 Mar; 132(3):432-40. PMID: 21091908.
    Citations: 12     Fields:    Translation:HumansCells
  124. Catassi C, Kryszak D, Bhatti B, Sturgeon C, Helzlsouer K, Clipp SL, Gelfond D, Puppa E, Sferruzza A, Fasano A. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med. 2010 Oct; 42(7):530-8. PMID: 20868314.
    Citations: 68     Fields:    Translation:Humans
  125. Goldblum SE, Rai U, Tripathi A, Thakar M, De Leo L, Di Toro N, Not T, Ramachandran R, Puche AC, Hollenberg MD, Fasano A. The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation. FASEB J. 2011 Jan; 25(1):144-58. PMID: 20852064.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  126. Catassi C, Fasano A. Celiac disease diagnosis: simple rules are better than complicated algorithms. Am J Med. 2010 Aug; 123(8):691-3. PMID: 20670718.
    Citations: 29     Fields:    Translation:Humans
  127. Shea-Donohue T, Fasano A, Smith A, Zhao A. Enteric pathogens and gut function: Role of cytokines and STATs. Gut Microbes. 2010 Sep; 1(5):316-324. PMID: 21327040.
    Citations: 16     Fields:    
  128. Fasano A, Counts D. Commentary on "anti-pituitary antibodies in children with newly diagnosed celiac disease: a novel finding contributing to linear growth". Am J Gastroenterol. 2010 Mar; 105(3):697-8. PMID: 20203647.
    Citations:    Fields:    Translation:Humans
  129. Harris KM, Fasano A, Mann DL. Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: implications for celiac disease. Clin Immunol. 2010 Jun; 135(3):430-9. PMID: 20153259.
    Citations: 14     Fields:    Translation:HumansCells
  130. Buzza MS, Netzel-Arnett S, Shea-Donohue T, Zhao A, Lin CY, List K, Szabo R, Fasano A, Bugge TH, Antalis TM. Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4200-5. PMID: 20142489.
    Citations: 67     Fields:    Translation:HumansCells
  131. Sapone A, Lammers KM, Mazzarella G, Mikhailenko I, Cartenì M, Casolaro V, Fasano A. Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch Allergy Immunol. 2010; 152(1):75-80. PMID: 19940509.
    Citations: 57     Fields:    Translation:HumansCells
  132. Zawahir S, Safta A, Fasano A. Pediatric celiac disease. Curr Opin Pediatr. 2009 Oct; 21(5):655-60. PMID: 19606042.
    Citations: 12     Fields:    Translation:Humans
  133. Fasano A. Should we screen for coeliac disease? Yes. BMJ. 2009 Sep 17; 339:b3592. PMID: 19762413.
    Citations: 14     Fields:    Translation:HumansPHPublic Health
  134. Tripathi A, Lammers KM, Goldblum S, Shea-Donohue T, Netzel-Arnett S, Buzza MS, Antalis TM, Vogel SN, Zhao A, Yang S, Arrietta MC, Meddings JB, Fasano A. Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16799-804. PMID: 19805376.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  135. Fasano A. Surprises from celiac disease. Sci Am. 2009 Aug; 301(2):54-61. PMID: 19634568.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  136. Lu R, Fasano S, Madayiputhiya N, Morin NP, Nataro J, Fasano A. Isolation, identification, and characterization of small bioactive peptides from Lactobacillus GG conditional media that exert both anti-Gram-negative and Gram-positive bactericidal activity. J Pediatr Gastroenterol Nutr. 2009 Jul; 49(1):23-30. PMID: 19465870.
    Citations: 12     Fields:    Translation:Cells
  137. Cascella NG, Kryszak D, Bhatti B, Gregory P, Kelly DL, Mc Evoy JP, Fasano A, Eaton WW. Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. Schizophr Bull. 2011 Jan; 37(1):94-100. PMID: 19494248.
    Citations: 38     Fields:    Translation:HumansCTClinical Trials
  138. Visser J, Rozing J, Sapone A, Lammers K, Fasano A. Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms. Ann N Y Acad Sci. 2009 May; 1165:195-205. PMID: 19538307.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  139. Catassi C, Fasano A. Celiac disease. Curr Opin Gastroenterol. 2008 Nov; 24(6):687-91. PMID: 19122516.
    Citations: 32     Fields:    Translation:Humans
  140. Fasano A. Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall. Am J Pathol. 2008 Nov; 173(5):1243-52. PMID: 18832585.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  141. Catassi C, Fasano A. Is this really celiac disease? Pitfalls in diagnosis. Curr Gastroenterol Rep. 2008 Oct; 10(5):466-72. PMID: 18799121.
    Citations: 6     Fields:    Translation:Humans
  142. Harris KM, Fasano A, Mann DL. Cutting edge: IL-1 controls the IL-23 response induced by gliadin, the etiologic agent in celiac disease. J Immunol. 2008 Oct 01; 181(7):4457-60. PMID: 18802048.
    Citations: 21     Fields:    Translation:HumansCells
  143. Rallabhandi P, Nhu QM, Toshchakov VY, Piao W, Medvedev AE, Hollenberg MD, Fasano A, Vogel SN. Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. J Biol Chem. 2008 Sep 05; 283(36):24314-25. PMID: 18622013.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  144. Lammers KM, Lu R, Brownley J, Lu B, Gerard C, Thomas K, Rallabhandi P, Shea-Donohue T, Tamiz A, Alkan S, Netzel-Arnett S, Antalis T, Vogel SN, Fasano A. Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology. 2008 Jul; 135(1):194-204.e3. PMID: 18485912.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  145. Song KH, Fasano A, Eddington ND. Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulator. Eur J Pharm Biopharm. 2008 May; 69(1):231-7. PMID: 18039562.
    Citations: 1     Fields:    Translation:AnimalsCells
  146. Song KH, Fasano A, Eddington ND. Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A. Int J Pharm. 2008 Mar 03; 351(1-2):8-14. PMID: 17954018.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  147. Antalis TM, Shea-Donohue T, Vogel SN, Sears C, Fasano A. Mechanisms of disease: protease functions in intestinal mucosal pathobiology. Nat Clin Pract Gastroenterol Hepatol. 2007 Jul; 4(7):393-402. PMID: 17607295.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  148. Catassi C, Kryszak D, Louis-Jacques O, Duerksen DR, Hill I, Crowe SE, Brown AR, Procaccini NJ, Wonderly BA, Hartley P, Moreci J, Bennett N, Horvath K, Burk M, Fasano A. Detection of Celiac disease in primary care: a multicenter case-finding study in North America. Am J Gastroenterol. 2007 Jul; 102(7):1454-60. PMID: 17355413.
    Citations: 58     Fields:    Translation:HumansPHPublic Health
  149. Goldberg D, Kryszak D, Fasano A, Green PH. Screening for celiac disease in family members: is follow-up testing necessary? Dig Dis Sci. 2007 Apr; 52(4):1082-6. PMID: 17380406.
    Citations: 7     Fields:    Translation:Humans
  150. Catassi C, Fabiani E, Iacono G, D'Agate C, Francavilla R, Biagi F, Volta U, Accomando S, Picarelli A, De Vitis I, Pianelli G, Gesuita R, Carle F, Mandolesi A, Bearzi I, Fasano A. A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. Am J Clin Nutr. 2007 Jan; 85(1):160-6. PMID: 17209192.
    Citations: 83     Fields:    Translation:Humans
  151. Fasano A. Systemic autoimmune disorders in celiac disease. Curr Opin Gastroenterol. 2006 Nov; 22(6):674-9. PMID: 17053448.
    Citations: 18     Fields:    Translation:HumansAnimals
  152. Branski D, Fasano A, Troncone R. Latest developments in the pathogenesis and treatment of celiac disease. J Pediatr. 2006 Sep; 149(3):295-300. PMID: 16939736.
    Citations: 7     Fields:    Translation:Humans
  153. Motlekar NA, Fasano A, Wachtel MS, Youan BB. Zonula occludens toxin synthetic peptide derivative AT1002 enhances in vitro and in vivo intestinal absorption of low molecular weight heparin. J Drug Target. 2006 Jun; 14(5):321-9. PMID: 16882552.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  154. Sapone A, de Magistris L, Pietzak M, Clemente MG, Tripathi A, Cucca F, Lampis R, Kryszak D, Cartenì M, Generoso M, Iafusco D, Prisco F, Laghi F, Riegler G, Carratu R, Counts D, Fasano A. Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes. 2006 May; 55(5):1443-9. PMID: 16644703.
    Citations: 104     Fields:    Translation:Humans
  155. Drago S, El Asmar R, Di Pierro M, Grazia Clemente M, Tripathi A, Sapone A, Thakar M, Iacono G, Carroccio A, D'Agate C, Not T, Zampini L, Catassi C, Fasano A. Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand J Gastroenterol. 2006 Apr; 41(4):408-19. PMID: 16635908.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  156. Gelfond D, Fasano A. Celiac disease in the pediatric population. Pediatr Ann. 2006 Apr; 35(4):275-9. PMID: 16637556.
    Citations: 3     Fields:    Translation:Humans
  157. Salama NN, Eddington ND, Fasano A. Tight junction modulation and its relationship to drug delivery. Adv Drug Deliv Rev. 2006 Apr 20; 58(1):15-28. PMID: 16517003.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  158. Thomas KE, Sapone A, Fasano A, Vogel SN. Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease. J Immunol. 2006 Feb 15; 176(4):2512-21. PMID: 16456012.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  159. Gadewar S, Fasano A. Celiac disease: is the atypical really typical? Summary of the recent National Institutes of Health Consensus Conference and latest advances. Curr Gastroenterol Rep. 2005 Dec; 7(6):455-61. PMID: 16313875.
    Citations: 2     Fields:    Translation:Humans
  160. Menon D, Karyekar CS, Fasano A, Lu R, Eddington ND. Enhancement of brain distribution of anticancer agents using DeltaG, the 12 kDa active fragment of ZOT. Int J Pharm. 2005 Dec 08; 306(1-2):122-31. PMID: 16274945.
    Citations: 1     Fields:    Translation:Animals
  161. De Angelis M, Rizzello CG, Fasano A, Clemente MG, De Simone C, Silano M, De Vincenzi M, Losito I, Gobbetti M. VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for Celiac Sprue. Biochim Biophys Acta. 2006 Jan; 1762(1):80-93. PMID: 16311022.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  162. Gadewar S, Fasano A. Current concepts in the evaluation, diagnosis and management of acute infectious diarrhea. Curr Opin Pharmacol. 2005 Dec; 5(6):559-65. PMID: 16207535.
    Citations: 11     Fields:    Translation:Humans
  163. Fasano A, Shea-Donohue T. Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol. 2005 Sep; 2(9):416-22. PMID: 16265432.
    Citations: 90     Fields:    Translation:Humans
  164. Fasano A, Catassi C. Coeliac disease in children. Best Pract Res Clin Gastroenterol. 2005 Jun; 19(3):467-78. PMID: 15925850.
    Citations: 17     Fields:    Translation:Humans
  165. Smecuol E, Sugai E, Niveloni S, Vázquez H, Pedreira S, Mazure R, Moreno ML, Label M, Mauriño E, Fasano A, Meddings J, Bai JC. Permeability, zonulin production, and enteropathy in dermatitis herpetiformis. Clin Gastroenterol Hepatol. 2005 Apr; 3(4):335-41. PMID: 15822038.
    Citations: 21     Fields:    Translation:Humans
  166. Fasano A. Clinical presentation of celiac disease in the pediatric population. Gastroenterology. 2005 Apr; 128(4 Suppl 1):S68-73. PMID: 15825129.
    Citations: 53     Fields:    Translation:Humans
  167. Watts T, Berti I, Sapone A, Gerarduzzi T, Not T, Zielke R, Fasano A. Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2916-21. PMID: 15710870.
    Citations: 69     Fields:    Translation:Animals
  168. Hill ID, Dirks MH, Liptak GS, Colletti RB, Fasano A, Guandalini S, Hoffenberg EJ, Horvath K, Murray JA, Pivor M, Seidman EG. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005 Jan; 40(1):1-19. PMID: 15625418.
    Citations: 185     Fields:    Translation:Humans
  169. Johnson TC, Diamond B, Memeo L, Negulescu H, Hovhanissyan Z, Verkarre V, Rotterdam H, Fasano A, Caillat-Zucman S, Grosdidier E, Winchester R, Cellier C, Jabri B, Green PH. Relationship of HLA-DQ8 and severity of celiac disease: comparison of New York and Parisian cohorts. Clin Gastroenterol Hepatol. 2004 Oct; 2(10):888-94. PMID: 15476152.
    Citations: 10     Fields:    Translation:HumansCells
  170. Salama NN, Fasano A, Thakar M, Eddington ND. The impact of DeltaG on the oral bioavailability of low bioavailable therapeutic agents. J Pharmacol Exp Ther. 2005 Jan; 312(1):199-205. PMID: 15448170.
    Citations: 8     Fields:    Translation:HumansAnimals
  171. Catassi C, Fasano A. Celiac disease as a cause of growth retardation in childhood. Curr Opin Pediatr. 2004 Aug; 16(4):445-9. PMID: 15273508.
    Citations: 9     Fields:    Translation:Humans
  172. Salazar-Lindo E, Allen S, Brewster DR, Elliott EJ, Fasano A, Phillips AD, Sanderson IR, Tarr PI. Intestinal infections and environmental enteropathy: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2004 Jun; 39 Suppl 2:S662-9. PMID: 15184767.
    Citations: 13     Fields:    Translation:HumansPHPublic Health
  173. Salama NN, Fasano A, Thakar M, Eddington ND. The effect of delta G on the transport and oral absorption of macromolecules. J Pharm Sci. 2004 May; 93(5):1310-9. PMID: 15067707.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  174. Fasano A, Nataro JP. Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins. Adv Drug Deliv Rev. 2004 Apr 19; 56(6):795-807. PMID: 15063590.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  175. Fasano A. Celiac disease--how to handle a clinical chameleon. N Engl J Med. 2003 Jun 19; 348(25):2568-70. PMID: 12815143.
    Citations: 21     Fields:    Translation:HumansCellsPHPublic Health
  176. Marinaro M, Fasano A, De Magistris MT. Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses. Infect Immun. 2003 Apr; 71(4):1897-902. PMID: 12654806.
    Citations: 10     Fields:    Translation:AnimalsCellsPHPublic Health
  177. Fasano A. Bioterrorism and biological warfare: not only a respiratory affair. J Pediatr Gastroenterol Nutr. 2003 Mar; 36(3):305-6. PMID: 12669708.
    Citations:    Fields:    Translation:HumansPHPublic Health
  178. Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, Elitsur Y, Green PH, Guandalini S, Hill ID, Pietzak M, Ventura A, Thorpe M, Kryszak D, Fornaroli F, Wasserman SS, Murray JA, Horvath K. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003 Feb 10; 163(3):286-92. PMID: 12578508.
    Citations: 329     Fields:    Translation:Humans
  179. Karyekar CS, Fasano A, Raje S, Lu R, Dowling TC, Eddington ND. Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells. J Pharm Sci. 2003 Feb; 92(2):414-23. PMID: 12532391.
    Citations: 16     Fields:    Translation:AnimalsCells
  180. Salama NN, Fasano A, Lu R, Eddington ND. Effect of the biologically active fragment of zonula occludens toxin, delta G, on the intestinal paracellular transport and oral absorption of mannitol. Int J Pharm. 2003 Jan 30; 251(1-2):113-21. PMID: 12527181.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  181. El Asmar R, Panigrahi P, Bamford P, Berti I, Not T, Coppa GV, Catassi C, Fasano A, El Asmar R. Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology. 2002 Nov; 123(5):1607-15. PMID: 12404235.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  182. Alaedini A, Green PH, Sander HW, Hays AP, Gamboa ET, Fasano A, Sonnenberg M, Lewis LD, Latov N. Ganglioside reactive antibodies in the neuropathy associated with celiac disease. J Neuroimmunol. 2002 Jun; 127(1-2):145-8. PMID: 12044986.
    Citations: 15     Fields:    Translation:Humans
  183. Catassi C, Fasano A. New developments in childhood celiac disease. Curr Gastroenterol Rep. 2002 Jun; 4(3):238-43. PMID: 12010625.
    Citations: 4     Fields:    Translation:Humans
  184. Rossi M, Maurano F, Luongo D, Fasano A, Uzzau S, Auricchio S, Troncone R. Zonula occludens toxin (Zot) interferes with the induction of nasal tolerance to gliadin. Immunol Lett. 2002 May 01; 81(3):217-21. PMID: 11947928.
    Citations: 2     Fields:    Translation:AnimalsCells
  185. Davidson G, Barnes G, Bass D, Cohen M, Fasano A, Fontaine O, Guandalini S. Infectious diarrhea in children: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 2:S143-50. PMID: 12192183.
    Citations: 11     Fields:    Translation:HumansPHPublic Health
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.