Harvard Catalyst Profiles

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Alessio Fasano, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56AI156711 (FASANO, ALESSIO) Jun 15, 2016 - Aug 31, 2022
    NIH
    The Celiac Disease Genome, Environment, Microbiome, and Metabolome (CD-GEMM) prospective cohort study
    Role: Principal Investigator
  2. R01DK104344 (FASANO, ALESSIO) Jun 15, 2016 - May 31, 2021
    NIH
    Microbiome-derived Metabolites Linked to Celiac Disease Onset in Infants at Risk
    Role: Principal Investigator
  3. R34AT006945 (VISCARDI, ROSE MARIE) Sep 1, 2011 - Jun 30, 2015
    NIH
    Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonates
    Role: Principal Investigator
  4. U19AI090873 (KAPER, JAMES B) Jul 20, 2010 - Jun 30, 2015
    NIH/NIAID
    Severe Enteric Disease: Pathogenesis and Response
    Role: Co-Principal Investigator
  5. U19AI082655 (SZTEIN, MARCELO B.) Jun 18, 2009 - May 31, 2019
    NIH/NIAID
    Mucusal and Systemic Immunity, Vaccines and Microbiota Interplay in Humans
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bartsch YC, St Denis KJ, Kaplonek P, Kang J, Lam EC, Burns MD, Farkas EJ, Davis JP, Boribong BP, Edlow AG, Fasano A, Shreffler WG, Zavadska D, Johnson M, Goldblatt D, Balazs AB, Yonker LM, Alter G. SARS-CoV-2 mRNA vaccination elicits robust antibody responses in children. Sci Transl Med. 2022 Nov 23; 14(672):eabn9237. PMID: 35881018; PMCID: PMC9348753.
    Citations:    Fields:    
  2. Beopoulos A, Géa M, Fasano A, Iris F. Autism spectrum disorders pathogenesis: Toward a comprehensive model based on neuroanatomic and neurodevelopment considerations. Front Neurosci. 2022; 16:988735. PMID: 36408388; PMCID: PMC9671112.
    Citations:    
  3. Di Micco S, Rahimova R, Sala M, Scala MC, Vivenzio G, Musella S, Andrei G, Remans K, Mammri L, Snoeck R, Bifulco G, Di Matteo F, Vestuto V, Campiglia P, Márquez JA, Fasano A. Rational design of the zonulin inhibitor AT1001 derivatives as potential anti SARS-CoV-2. Eur J Med Chem. 2022 Dec 15; 244:114857. PMID: 36332548; PMCID: PMC9579148.
    Citations:    Fields:    
  4. Burns MD, Muir C, Atyeo C, Davis JP, Demidkin S, Akinwunmi B, Fasano A, Gray KJ, Alter G, Shook LL, Edlow AG, Yonker LM. Relationship between Anti-Spike Antibodies and Risk of SARS-CoV-2 Infection in Infants Born to COVID-19 Vaccinated Mothers. Vaccines (Basel). 2022 Oct 11; 10(10). PMID: 36298561; PMCID: PMC9610427.
    Citations:    
  5. Seidita A, Mansueto P, Giuliano A, Chiavetta M, Mandreucci F, Soresi M, Pistone M, Compagnoni S, Castellucci D, Bisso G, Faraci F, Maestri S, Disclafani R, Sapone A, Fasano A, Carroccio A. Potential tolerability of ancient grains in non-celiac wheat sensitivity patients: A preliminary evaluation. Front Med (Lausanne). 2022; 9:995019. PMID: 36250065; PMCID: PMC9554215.
    Citations:    
  6. El Mouzan M, Al-Hussaini A, Serena G, Assiri A, Al Sarkhy A, Al Mofarreh M, Alasmi M, Fasano A. Microbiota profile of new-onset celiac disease in children in Saudi Arabia. Gut Pathog. 2022 Sep 08; 14(1):37. PMID: 36076257; PMCID: PMC9461150.
    Citations:    
  7. Troisi J, Lombardi M, Scala G, Cavallo P, Tayler RS, Symes SJK, Richards SM, Adair DC, Fasano A, McCowan LM, Guida M. A screening test proposal for congenital defects based on maternal serum metabolomics profile. Am J Obstet Gynecol. 2022 Sep 06. PMID: 36075482.
    Citations:    Fields:    
  8. Ali Ibrahim A, Kenyon V, Fasano A, Leonard MM. Budesonide and the Gluten Containing Elimination Diet as Treatments for Non-responsive Celiac Disease in Children. J Pediatr Gastroenterol Nutr. 2022 Nov 01; 75(5):616-622. PMID: 36305882; PMCID: PMC9627632.
    Citations:    Fields:    Translation:Humans
  9. Atyeo C, Shook LL, Nziza N, Deriso EA, Muir C, Baez AM, Lima RS, Demidkin S, Brigida S, De Guzman RM, Burns MD, Balazs AB, Fasano A, Yonker LM, Gray KJ, Alter G, Edlow AG. COVID-19 booster dose induces robust antibody response in pregnant, lactating, and nonpregnant women. Am J Obstet Gynecol. 2022 Jul 19. PMID: 35868417; PMCID: PMC9295313.
    Citations:    Fields:    
  10. Yonker LM, Badaki-Makun O, Arya P, Boribong BP, Moraru G, Fenner B, Rincon J, Hopke A, Rogers B, Hinson J, Fasano A, Lee L, Kehoe SM, Larson SD, Chavez H, Levin S, Moldawer LL, Irimia D. Correction to: Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications. BMC Infect Dis. 2022 Jul 07; 22(1):595. PMID: 35799137; PMCID: PMC9260969.
    Citations:    Fields:    
  11. Stuart CM, Varatharaj A, Winberg ME, Galea P, Larsson HBW, Cramer SP, Fasano A, Maherally Z, Pilkington GJ, Keita ÅV, Galea I. Zonulin and blood-brain barrier permeability are dissociated in humans. Clin Transl Med. 2022 07; 12(7):e965. PMID: 35808833; PMCID: PMC9270641.
    Citations:    Fields:    Translation:Humans
  12. Atyeo CG, Shook LL, Brigida S, De Guzman RM, Demidkin S, Muir C, Akinwunmi B, Baez AM, Sheehan ML, McSweeney E, Burns MD, Nayak R, Kumar MK, Patel CD, Fialkowski A, Cvrk D, Goldfarb IT, Yonker LM, Fasano A, Balazs AB, Elovitz MA, Gray KJ, Alter G, Edlow AG. Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms. Nat Commun. 2022 06 28; 13(1):3571. PMID: 35764643; PMCID: PMC9239994.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  13. Aiemjoy K, Seidman JC, Saha S, Munira SJ, Islam Sajib MS, Sium SMA, Sarkar A, Alam N, Zahan FN, Kabir MS, Tamrakar D, Vaidya K, Shrestha R, Shakya J, Katuwal N, Shrestha S, Yousafzai MT, Iqbal J, Dehraj IF, Ladak Y, Maria N, Adnan M, Pervaiz S, Carter AS, Longley AT, Fraser C, Ryan ET, Nodoushani A, Fasano A, Leonard MM, Kenyon V, Bogoch II, Jeon HJ, Haselbeck A, Park SE, Zellweger RM, Marks F, Owusu-Dabo E, Adu-Sarkodie Y, Owusu M, Teunis P, Luby SP, Garrett DO, Qamar FN, Saha SK, Charles RC, Andrews JR. Estimating typhoid incidence from community-based serosurveys: a multicohort study. Lancet Microbe. 2022 08; 3(8):e578-e587. PMID: 35750069; PMCID: PMC9329131.
    Citations:    
  14. Yonker LM, Badaki-Makun O, Arya P, Boribong BP, Moraru G, Fenner B, Rincon J, Hopke A, Rogers B, Hinson J, Fasano A, Lee L, Kehoe SM, Larson SD, Chavez H, Levin S, Moldawer LL, Irimia D. Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications. BMC Infect Dis. 2022 Jun 20; 22(1):563. PMID: 35725405; PMCID: PMC9208352.
    Citations: 1     Fields:    Translation:HumansCells
  15. Rostami K, Ensari A, Marsh MN, Srivastava A, Villanacci V, Carroccio A, Asadzadeh Aghdaei H, Bai JC, Bassotti G, Becheanu G, Bell P, Di Bella C, Bozzola AM, Cadei M, Casella G, Catassi C, Ciacci C, Apostol Ciobanu DG, Cross SS, Danciu M, Das P, Del Sordo R, Drage M, Elli L, Fasano A, Florena AM, Fusco N, Going JJ, Guandalini S, Hagen CE, Hayman DTS, Ishaq S, Jericho H, Johncilla M, Johnson M, Kaukinen K, Levene A, Liptrot S, Lu L, Makharia GK, Mathews S, Mazzarella G, Maxim R, La Win Myint K, Mohaghegh-Shalmani H, Moradi A, Mulder CJJ, Ray R, Ricci C, Rostami-Nejad M, Sapone A, Sanders DS, Taavela J, Volta U, Walker M, Derakhshan M. Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity: A Multicentre Study. Nutrients. 2022 Jun 15; 14(12). PMID: 35745217; PMCID: PMC9230100.
    Citations:    Fields:    Translation:Humans
  16. Martinez EE, Mehta NM, Fasano A. The Zonulin Pathway as a Potential Mediator of Gastrointestinal Dysfunction in Critical Illness. Pediatr Crit Care Med. 2022 09 01; 23(9):e424-e428. PMID: 35543388.
    Citations:    Fields:    
  17. Burns MD, Boribong BP, Bartsch YC, Loiselle M, St Denis KJ, Sheehan ML, Chen JW, Davis JP, Lima R, Edlow AG, Fasano A, Balazs AB, Alter G, Yonker LM. Durability and Cross-Reactivity of SARS-CoV-2 mRNA Vaccine in Adolescent Children. Vaccines (Basel). 2022 Mar 23; 10(4). PMID: 35455241; PMCID: PMC9032590.
    Citations: 1     
  18. Shook LL, Atyeo CG, Yonker LM, Fasano A, Gray KJ, Alter G, Edlow AG. Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Natural Infection. JAMA. 2022 03 15; 327(11):1087-1089. PMID: 35129576; PMCID: PMC8822441.
    Citations: 7     Fields:    Translation:Humans
  19. Yonker LM, Swank Z, Gilboa T, Senussi Y, Kenyon V, Papadakis L, Boribong BP, Carroll RW, Walt DR, Fasano A. Zonulin Antagonist, Larazotide (AT1001), As an Adjuvant Treatment for Multisystem Inflammatory Syndrome in Children: A Case Series. Crit Care Explor. 2022 Feb; 10(2):e0641. PMID: 35211683; PMCID: PMC8860335.
    Citations: 1     
  20. Burns MD, Boribong BP, Bartsch YC, Loiselle M, Davis JP, Lima R, Edlow AG, Fasano A, Alter G, Yonker LM. Durability and cross-reactivity of SARS-CoV-2 mRNA vaccine in adolescent children. medRxiv. 2022 Feb 16. PMID: 35194616; PMCID: PMC8863160.
    Citations:    
  21. Bartsch YC, St Denis KJ, Kaplonek P, Kang J, Lam EC, Burns MD, Farkas EJ, Davis JP, Boribong BP, Edlow AG, Fasano A, Shreffler W, Zavadska D, Johnson M, Goldblatt D, Balazs AB, Yonker LM, Alter G. Comprehensive antibody profiling of mRNA vaccination in children. bioRxiv. 2022 Jan 04. PMID: 35018376; PMCID: PMC8750651.
    Citations:    
  22. Farina F, Pisapia L, Laezza M, Serena G, Rispo A, Ricciolino S, Gianfrani C, Fasano A, Del Pozzo G. Effect of Gliadin Stimulation on HLA-DQ2.5 Gene Expression in Macrophages from Adult Celiac Disease Patients. Biomedicines. 2021 Dec 29; 10(1). PMID: 35052743; PMCID: PMC8773327.
    Citations: 1     
  23. Beopoulos A, Gea M, Fasano A, Iris F. Autonomic Nervous System Neuroanatomical Alterations Could Provoke and Maintain Gastrointestinal Dysbiosis in Autism Spectrum Disorder (ASD): A Novel Microbiome-Host Interaction Mechanistic Hypothesis. Nutrients. 2021 Dec 24; 14(1). PMID: 35010940; PMCID: PMC8746684.
    Citations:    Fields:    Translation:Humans
  24. Boribong BP, LaSalle TJ, Bartsch YC, Ellett F, Loiselle ME, Davis JP, Gonye ALK, Hajizadeh S, Kreuzer J, Pillai S, Haas W, Edlow A, Fasano A, Alter G, Irimia D, Sade-Feldman M, Yonker LM. Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children. bioRxiv. 2021 Dec 20. PMID: 34981052; PMCID: PMC8722589.
    Citations: 1     
  25. Yonker LM, Boucau J, Regan J, Choudhary MC, Burns MD, Young N, Farkas EJ, Davis JP, Moschovis PP, Bernard Kinane T, Fasano A, Neilan AM, Li JZ, Barczak AK. Virologic Features of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children. J Infect Dis. 2021 12 01; 224(11):1821-1829. PMID: 34647601; PMCID: PMC8643403.
    Citations: 21     Fields:    Translation:HumansCellsPHPublic Health
  26. Martinez EE, Lan J, Konno T, Miranda-Ribera A, Fiorentino M, Mehta NM, Fasano A. Novel role of zonulin in the pathophysiology of gastro-duodenal transit: a clinical and translational study. Sci Rep. 2021 11 17; 11(1):22462. PMID: 34789790; PMCID: PMC8599512.
    Citations:    Fields:    Translation:HumansAnimals
  27. Miranda-Ribera A, Serena G, Liu J, Fasano A, Kingsbury MA, Fiorentino MR. The Zonulin-transgenic mouse displays behavioral alterations ameliorated via depletion of the gut microbiota. Tissue Barriers. 2022 07 03; 10(3):2000299. PMID: 34775911; PMCID: PMC9359372.
    Citations: 1     Fields:    
  28. Pérez-Sáez MJ, Uffing A, Leon J, Murakami N, Watanabe A, Borges TJ, Sabbisetti VS, Cureton P, Kenyon V, Keating L, Yee K, Fernandes Satiro CA, Serena G, Hildebrandt F, Riella CV, Libermann TA, Wang M, Pascual J, Bonventre JV, Cravedi P, Fasano A, Riella LV. Corrigendum: Immunological Impact of a Gluten-Free Dairy-Free Diet in Children With Kidney Disease: A Feasibility Study. Front Immunol. 2021; 12:798560. PMID: 34795679; PMCID: PMC8594461.
    Citations:    Fields:    
  29. Bordt EA, Shook LL, Atyeo C, Pullen KM, De Guzman RM, Meinsohn MC, Chauvin M, Fischinger S, Yockey LJ, James K, Lima R, Yonker LM, Fasano A, Brigida S, Bebell LM, Roberts DJ, Pépin D, Huh JR, Bilbo SD, Li JZ, Kaimal A, Schust DJ, Gray KJ, Lauffenburger D, Alter G, Edlow AG. Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses. Sci Transl Med. 2021 Oct 27; 13(617):eabi7428. PMID: 34664987; PMCID: PMC8784281.
    Citations: 14     Fields:    Translation:HumansCellsPHPublic Health
  30. Atyeo C, DeRiso EA, Davis C, Bordt EA, De Guzman RM, Shook LL, Yonker LM, Fasano A, Akinwunmi B, Lauffenburger DA, Elovitz MA, Gray KJ, Edlow AG, Alter G. COVID-19 mRNA vaccines drive differential antibody Fc-functional profiles in pregnant, lactating, and nonpregnant women. Sci Transl Med. 2021 Oct 27; 13(617):eabi8631. PMID: 34664972; PMCID: PMC9067624.
    Citations: 19     Fields:    Translation:HumansCells
  31. Porritt RA, Binek A, Paschold L, Rivas MN, McArdle A, Yonker LM, Alter G, Chandnani HK, Lopez M, Fasano A, Van Eyk JE, Binder M, Arditi M. The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children. J Clin Invest. 2021 10 15; 131(20). PMID: 34437303; PMCID: PMC8516454.
    Citations: 23     Fields:    Translation:Humans
  32. Leonard MM, Colwell RR, Fasano A. Reply to Chen and Vitetta: Unraveling the complex interactions among organisms in the microbiome is necessary to identify unique signatures predicting CD onset. Proc Natl Acad Sci U S A. 2021 10 12; 118(41). PMID: 34607963; PMCID: PMC8521656.
    Citations:    Fields:    Translation:Humans
  33. Mehrotra I, Serena G, Cetinbas M, Kenyon V, Martin VM, Harshman SG, Zomorrodi AR, Sadreyev RI, Fasano A, Leonard MM. Characterization of the blood microbiota in children with Celiac disease. Curr Res Microb Sci. 2021 Dec; 2:100069. PMID: 34841359; PMCID: PMC8610358.
    Citations:    
  34. Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A. Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. Int J Mol Sci. 2021 Aug 30; 22(17). PMID: 34502335.
    Citations: 1     Fields:    Translation:HumansCells
  35. Yonker LM, Boucau J, Regan J, Choudhary MC, Burns MD, Young N, Farkas EJ, Davis JP, Moschovis PP, Kinane TB, Fasano A, Neilan AM, Li JZ, Barczak AK. Virologic features of SARS-CoV-2 infection in children. medRxiv. 2021 Aug 17. PMID: 34124714; PMCID: PMC8193793.
    Citations:    
  36. de Oliveira GLV, Cardoso CRB, Taneja V, Fasano A. Editorial: Intestinal Dysbiosis in Inflammatory Diseases. Front Immunol. 2021; 12:727485. PMID: 34394133.
    Citations: 1     Fields:    Translation:HumansAnimals
  37. Leonard MM, Valitutti F, Karathia H, Pujolassos M, Kenyon V, Fanelli B, Troisi J, Subramanian P, Camhi S, Colucci A, Serena G, Cucchiara S, Trovato CM, Malamisura B, Francavilla R, Elli L, Hasan NA, Zomorrodi AR, Colwell R, Fasano A. Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study. Proc Natl Acad Sci U S A. 2021 07 20; 118(29). PMID: 34253606.
    Citations: 10     Fields:    Translation:Humans
  38. Yonker LM, Gilboa T, Ogata AF, Senussi Y, Lazarovits R, Boribong BP, Bartsch YC, Loiselle M, Rivas MN, Porritt RA, Lima R, Davis JP, Farkas EJ, Burns MD, Young N, Mahajan VS, Hajizadeh S, Lopez XIH, Kreuzer J, Morris R, Martinez EE, Han I, Griswold K, Barry NC, Thompson DB, Church G, Edlow AG, Haas W, Pillai S, Arditi M, Alter G, Walt DR, Fasano A. Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier. J Clin Invest. 2021 07 15; 131(14). PMID: 34032635; PMCID: PMC8279585.
    Citations: 42     Fields:    Translation:HumansCells
  39. Matei DE, Menon M, Alber DG, Smith AM, Nedjat-Shokouhi B, Fasano A, Magill L, Duhlin A, Bitoun S, Gleizes A, Hacein-Bey-Abina S, Manson JJ, Rosser EC, Klein N, Blair PA, Mauri C. Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease. Med (N Y). 2021 07 09; 2(7):864-883.e9. PMID: 34296202; PMCID: PMC8280953.
    Citations: 5     Translation:HumansAnimals
  40. Olshan KL, Zomorrodi AR, Pujolassos M, Troisi J, Khan N, Fanelli B, Kenyon V, Fasano A, Leonard MM. Microbiota and Metabolomic Patterns in the Breast Milk of Subjects with Celiac Disease on a Gluten-Free Diet. Nutrients. 2021 Jun 29; 13(7). PMID: 34210038.
    Citations: 1     Fields:    Translation:Humans
  41. Shah NB, Nigwekar SU, Kalim S, Lelouvier B, Servant F, Dalal M, Krinsky S, Fasano A, Tolkoff-Rubin N, Allegretti AS. The Gut and Blood Microbiome in IgA Nephropathy and Healthy Controls. Kidney360. 2021 08 26; 2(8):1261-1274. PMID: 35369657; PMCID: PMC8676391.
    Citations: 1     Translation:Humans
  42. Nickerson KP, Llanos-Chea A, Ingano L, Serena G, Miranda-Ribera A, Perlman M, Lima R, Sztein MB, Fasano A, Senger S, Faherty CS. A Versatile Human Intestinal Organoid-Derived Epithelial Monolayer Model for the Study of Enteric Pathogens. Microbiol Spectr. 2021 09 03; 9(1):e0000321. PMID: 34106568; PMCID: PMC8552518.
    Citations: 6     Fields:    Translation:HumansCells