Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

David Erich Fisher, M.D., Ph.D.

Title
Institution
Department
Address
Phone
Fax
Other Positions
Title
Institution
Department

Mentoring
completed student projects
Targeting Cdk2 for Therapy of Clear Cell Sarcoma and Pediatraic Renal Carcinoma
Summer, 06/20/05 - 08/05/05

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01CA222871 (FISHER, DAVID E) Jan 1, 2018 - Dec 31, 2022
    NIH/NCI
    A druggable dependency in low-MITF/high-AXL melanoma: preclinical efficacy and mechanism of action in a key treatment-resistant subclass.
    Role: Principal Investigator
  2. R01AR072304 (FISHER, DAVID E) Aug 1, 2017 - Jul 31, 2022
    NIH/NIAMS
    Preclinical models and therapeutic strategies for treatment of giant congenital melanocytic nevi
    Role: Principal Investigator
  3. R21CA175907 (FISHER, DAVID E) Sep 27, 2013 - Aug 31, 2015
    NIH/NCI
    Development of next-generation cancer functional diagnostics
    Role: Principal Investigator
  4. P01CA163222 (FISHER, DAVID E) Mar 12, 2013 - Feb 28, 2018
    NIH/NCI
    Overcoming resistance to BRAF(V600E) targeted therapies in melanoma
    Role: Principal Investigator
  5. R01CA150226 (FISHER, DAVID E) Apr 1, 2011 - Mar 31, 2016
    NIH/NCI
    Role of beta-endorphin in cancer therapy induced fatigue
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chow MT, Ozga AJ, Servis RL, Frederick DT, Lo JA, Fisher DE, Freeman GJ, Boland GM, Luster AD. Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy. Immunity. 2019 May 06. PMID: 31097342.
    Citations:    
  2. Bai X, Fisher DE, Flaherty KT. Cell-state dynamics and therapeutic resistance in melanoma from the perspective of MITF and IFN? pathways. Nat Rev Clin Oncol. 2019 Apr 09. PMID: 30967646.
    Citations:    
  3. Rachmin I, Fisher DE. Microphthalmia-associated transcription factor phosphorylation: Cross talk between GSK3 and MAPK signaling. Pigment Cell Melanoma Res. 2019 05; 32(3):345-347. PMID: 30633855.
    Citations:    Fields:    
  4. Cardoso C, Serafim RB, Kawakami A, Gonçalves Pereira C, Roszik J, Valente V, Vazquez VL, Fisher DE, Espreafico EM. The lncRNA RMEL3 protects immortalized cells from serum withdrawal-induced growth arrest and promotes melanoma cell proliferation and tumor growth. Pigment Cell Melanoma Res. 2019 03; 32(2):303-314. PMID: 30457212.
    Citations:    
  5. Hejna M, Moon WM, Cheng J, Kawakami A, Fisher DE, Song JS. Local genomic features predict the distinct and overlapping binding patterns of the bHLH-Zip family oncoproteins MITF and MYC-MAX. Pigment Cell Melanoma Res. 2018 Dec 07. PMID: 30548162.
    Citations:    Fields:    
  6. Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HM. Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential. Trends Endocrinol Metab. 2018 10; 29(10):723-735. PMID: 30150136.
    Citations:    Fields:    
  7. Nguyen NT, Fisher DE. MITF and UV responses in skin: From pigmentation to addiction. Pigment Cell Melanoma Res. 2019 03; 32(2):224-236. PMID: 30019545.
    Citations:    Fields:    
  8. McConnell AM, Mito JK, Ablain J, Dang M, Formichella L, Fisher DE, Zon LI. Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion. Dev Biol. 2019 May 15; 449(2):107-114. PMID: 29883661.
    Citations:    Fields:    
  9. Kemeny LV, Fisher DE. Targeting the (Un)differentiated State of Cancer. Cancer Cell. 2018 05 14; 33(5):793-795. PMID: 29763619.
    Citations:    Fields:    
  10. Huang JT, Song JS, Hawryluk EB, London WB, Guo D, Sridharan M, Fisher DE, Lehmann LE, Duncan CN. Nonmalignant late cutaneous changes after allogeneic hematopoietic stem cell transplant in children. J Am Acad Dermatol. 2018 Aug; 79(2):230-237. PMID: 29588248.
    Citations:    Fields:    Translation:Humans
  11. Erlich TH, Fisher DE. Pathways in melanoma development. G Ital Dermatol Venereol. 2018 Feb; 153(1):68-76. PMID: 29319276.
    Citations: 1     Fields:    Translation:Humans
  12. Wu X, Fisher DE. Negative Regulation of Skin Pigmentation in Three-Dimensional Reconstructs by Adipose-Derived Mesenchymal Cells. J Invest Dermatol. 2017 12; 137(12):2464-2466. PMID: 29169460.
    Citations:    Fields:    
  13. Salma N, Song JS, Kawakami A, Devi SP, Khaled M, Cacicedo JM, Fisher DE. Erratum for Salma et al., "Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor ?2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice". Mol Cell Biol. 2017 11 01; 37(21). PMID: 29030472.
    Citations:    Fields:    
  14. Heppt MV, Wang JX, Hristova DM, Wei Z, Li L, Evans B, Beqiri M, Zaman S, Zhang J, Irmler M, Berking C, Besch R, Beckers J, Rauscher FJ, Sturm RA, Fisher DE, Herlyn M, Fukunaga-Kalabis M. MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression. J Invest Dermatol. 2018 01; 138(1):141-149. PMID: 28927893.
    Citations: 1     Fields:    
  15. Dai J, Choo MK, Park JM, Fisher DE. Topical ROR Inverse Agonists Suppress Inflammation in Mouse Models of Atopic Dermatitis and Acute Irritant Dermatitis. J Invest Dermatol. 2017 12; 137(12):2523-2531. PMID: 28774591.
    Citations:    Fields:    Translation:AnimalsCells
  16. Manguso RT, Pope HW, Zimmer MD, Brown FD, Yates KB, Miller BC, Collins NB, Bi K, LaFleur MW, Juneja VR, Weiss SA, Lo J, Fisher DE, Miao D, Van Allen E, Root DE, Sharpe AH, Doench JG, Haining WN. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target. Nature. 2017 07 27; 547(7664):413-418. PMID: 28723893.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  17. Salma N, Song JS, Kawakami A, Devi SP, Khaled M, Cacicedo JM, Fisher DE. Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor ?2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice. Mol Cell Biol. 2017 08 01; 37(15). PMID: 28483914.
    Citations: 1     Fields:    Translation:AnimalsCells
  18. Tateishi K, Higuchi F, Miller JJ, Koerner MVA, Lelic N, Shankar GM, Tanaka S, Fisher DE, Batchelor TT, Iafrate AJ, Wakimoto H, Chi AS, Cahill DP. The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion-Mediated Cytotoxicity. Cancer Res. 2017 08 01; 77(15):4102-4115. PMID: 28625978.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  19. Mujahid N, Liang Y, Murakami R, Choi HG, Dobry AS, Wang J, Suita Y, Weng QY, Allouche J, Kemeny LV, Hermann AL, Roider EM, Gray NS, Fisher DE. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017 06 13; 19(11):2177-2184. PMID: 28614705.
    Citations: 2     Fields:    Translation:HumansAnimals
  20. Byrne EH, Fisher DE. Immune and molecular correlates in melanoma treated with immune checkpoint blockade. Cancer. 2017 06 01; 123(S11):2143-2153. PMID: 28543699.
    Citations: 3     Fields:    Translation:HumansCells
  21. Friedman AA, Xia Y, Trippa L, Le LP, Igras V, Frederick DT, Wargo JA, Tanabe KK, Lawrence DP, Neuberg DS, Flaherty KT, Fisher DE. Feasibility of Ultra-High-Throughput Functional Screening of Melanoma Biopsies for Discovery of Novel Cancer Drug Combinations. Clin Cancer Res. 2017 Aug 15; 23(16):4680-4692. PMID: 28446504.
    Citations: 1     Fields:    Translation:HumansAnimals
  22. Kawakami A, Fisher DE. The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology. Lab Invest. 2017 06; 97(6):649-656. PMID: 28263292.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  23. Chen X, Chen H, Cai W, Maguire M, Ya B, Zuo F, Logan R, Li H, Robinson K, Vanderburg CR, Yu Y, Wang Y, Fisher DE, Schwarzschild MA. The melanoma-linked "redhead" MC1R influences dopaminergic neuron survival. Ann Neurol. 2017 Mar; 81(3):395-406. PMID: 28019657.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  24. Su MY, Fisher DE. Immunotherapy in the Precision Medicine Era: Melanoma and Beyond. PLoS Med. 2016 Dec; 13(12):e1002196. PMID: 27959922.
    Citations: 4     Fields:    Translation:Humans
  25. Alves CP, Yokoyama S, Goedert L, Pontes CLS, Sousa JF, Fisher DE, Espreafico EM. MYO5A Gene Is a Target of MITF in Melanocytes. J Invest Dermatol. 2017 04; 137(4):985-989. PMID: 27939378.
    Citations:    Fields:    Translation:HumansCells
  26. Lin WM, Fisher DE. Signaling and Immune Regulation in Melanoma Development and Responses to Therapy. Annu Rev Pathol. 2017 Jan 24; 12:75-102. PMID: 27959628.
    Citations:    Fields:    Translation:HumansAnimalsCells
  27. Kawakami A, Fisher DE. Bioinformatic Analysis of Gene Expression for Melanoma Treatment. J Invest Dermatol. 2016 12; 136(12):2342-2344. PMID: 27884291.
    Citations:    Fields:    Translation:Humans
  28. Wang H, Osseiran S, Igras V, Nichols AJ, Roider EM, Pruessner J, Tsao H, Fisher DE, Evans CL. In vivo coherent Raman imaging of the melanomagenesis-associated pigment pheomelanin. Sci Rep. 2016 11 28; 6:37986. PMID: 27892516.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  29. Ibrahim N, Buchbinder EI, Granter SR, Rodig SJ, Giobbie-Hurder A, Becerra C, Tsiaras A, Gjini E, Fisher DE, Hodi FS. A phase I trial of panobinostat (LBH589) in patients with metastatic melanoma. Cancer Med. 2016 11; 5(11):3041-3050. PMID: 27748045.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  30. Shen CH, Kim SH, Trousil S, Frederick DT, Piris A, Yuan P, Cai L, Gu L, Li M, Lee JH, Mitra D, Fisher DE, Sullivan RJ, Flaherty KT, Zheng B. Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma. Nat Med. 2016 09; 22(9):1056-61. PMID: 27500726.
    Citations: 4     Fields:    Translation:HumansCells
  31. Roider EM, Fisher DE. Red Hair, Light Skin, and UV-Independent Risk for Melanoma Development in Humans. JAMA Dermatol. 2016 07 01; 152(7):751-3. PMID: 27050924.
    Citations: 2     Fields:    Translation:Humans
  32. Xia Y, Li Y, Westover KD, Sun J, Chen H, Zhang J, Fisher DE. Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and a-Mangostin. PLoS One. 2016; 11(5):e0155217. PMID: 27152946.
    Citations: 3     Fields:    Translation:HumansCells
  33. Merlino G, Herlyn M, Fisher DE, Bastian BC, Flaherty KT, Davies MA, Wargo JA, Curiel-Lewandrowski C, Weber MJ, Leachman SA, Soengas MS, McMahon M, Harbour JW, Swetter SM, Aplin AE, Atkins MB, Bosenberg MW, Dummer R, Gershenwald JE, Halpern AC, Herlyn D, Karakousis GC, Kirkwood JM, Krauthammer M, Lo RS, Long GV, McArthur G, Ribas A, Schuchter L, Sosman JA, Smalley KS, Steeg P, Thomas NE, Tsao H, Tueting T, Weeraratna A, Xu G, Lomax R, Martin A, Silverstein S, Turnham T, Ronai ZA. The state of melanoma: challenges and opportunities. Pigment Cell Melanoma Res. 2016 07; 29(4):404-16. PMID: 27087480.
    Citations: 16     Fields:    Translation:HumansCells
  34. Tateishi K, Wakimoto H, Iafrate AJ, Tanaka S, Loebel F, Lelic N, Wiederschain D, Bedel O, Deng G, Zhang B, He T, Shi X, Gerszten RE, Zhang Y, Yeh JJ, Curry WT, Zhao D, Sundaram S, Nigim F, Koerner MVA, Ho Q, Fisher DE, Roider EM, Kemeny LV, Samuels Y, Flaherty KT, Batchelor TT, Chi AS, Cahill DP. Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion. Cancer Cell. 2015 Dec 14; 28(6):773-784. PMID: 26678339.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  35. Lo JA, Fisher DE, Flaherty KT. Prognostic Significance of Cutaneous Adverse Events Associated With Pembrolizumab Therapy. JAMA Oncol. 2015 Dec; 1(9):1340-1. PMID: 26270186.
    Citations: 7     Fields:    Translation:Humans
  36. Friedman AA, Letai A, Fisher DE, Flaherty KT. Precision medicine for cancer with next-generation functional diagnostics. Nat Rev Cancer. 2015 Dec; 15(12):747-56. PMID: 26536825.
    Citations: 69     Fields:    Translation:Humans
  37. Friedman AA, Amzallag A, Pruteanu-Malinici I, Baniya S, Cooper ZA, Piris A, Hargreaves L, Igras V, Frederick DT, Lawrence DP, Haber DA, Flaherty KT, Wargo JA, Ramaswamy S, Benes CH, Fisher DE. Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment. PLoS One. 2015; 10(10):e0140310. PMID: 26461489.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  38. Salma N, Song JS, Arany Z, Fisher DE. Transcription Factor Tfe3 Directly Regulates Pgc-1alpha in Muscle. J Cell Physiol. 2015 Oct; 230(10):2330-6. PMID: 25736533.
    Citations: 5     Fields:    Translation:AnimalsCells
  39. Lu FK, Basu S, Igras V, Hoang MP, Ji M, Fu D, Holtom GR, Neel VA, Freudiger CW, Fisher DE, Xie XS. Label-free DNA imaging in vivo with stimulated Raman scattering microscopy. Proc Natl Acad Sci U S A. 2015 Sep 15; 112(37):11624-9. PMID: 26324899.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  40. Dadras SS, Lin RJ, Fisher DE. Authors' Reply. Am J Pathol. 2015 Jul; 185(7):2070. PMID: 26093987.
    Citations:    
  41. Liu XS, Genet MD, Haines JE, Mehanna EK, Wu S, Chen HI, Chen Y, Qureshi AA, Han J, Chen X, Fisher DE, Pandolfi PP, Yuan ZM. ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM. Mol Cancer Res. 2015 Aug; 13(8):1206-17. PMID: 25995384.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  42. Schadendorf D, Fisher DE, Garbe C, Gershenwald JE, Grob JJ, Halpern A, Herlyn M, Marchetti MA, McArthur G, Ribas A, Roesch A, Hauschild A. Melanoma. Nat Rev Dis Primers. 2015 04 23; 1:15003. PMID: 27188223.
    Citations: 46     Fields:    Translation:HumansCells
  43. Goldberg JM, Fisher DE, Demetri GD, Neuberg D, Allsop SA, Fonseca C, Nakazaki Y, Nemer D, Raut CP, George S, Morgan JA, Wagner AJ, Freeman GJ, Ritz J, Lezcano C, Mihm M, Canning C, Hodi FS, Dranoff G. Biologic Activity of Autologous, Granulocyte-Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines. Clin Cancer Res. 2015 Jul 15; 21(14):3178-86. PMID: 25805798.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  44. Zheng B, Fisher DE. Metabolic vulnerability in melanoma: a ME2 (me too) story. J Invest Dermatol. 2015 Mar; 135(3):657-659. PMID: 25666673.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  45. Lauss M, Haq R, Cirenajwis H, Phung B, Harbst K, Staaf J, Rosengren F, Holm K, Aine M, Jirström K, Borg Å, Busch C, Geisler J, Lønning PE, Ringnér M, Howlin J, Fisher DE, Jönsson G. Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation. J Invest Dermatol. 2015 Jul; 135(7):1820-1828. PMID: 25705847.
    Citations: 13     Fields:    Translation:HumansCells
  46. Lo JA, Fisher DE. The melanoma revolution: from UV carcinogenesis to a new era in therapeutics. Science. 2014 Nov 21; 346(6212):945-9. PMID: 25414302.
    Citations: 65     Fields:    Translation:HumansCells
  47. Dadras SS, Lin RJ, Razavi G, Kawakami A, Du J, Feige E, Milner DA, Loda MF, Granter SR, Detmar M, Widlund HR, Horstmann MA, Fisher DE. A novel role for microphthalmia-associated transcription factor-regulated pigment epithelium-derived factor during melanoma progression. Am J Pathol. 2015 Jan; 185(1):252-65. PMID: 25447045.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  48. Robinson KC, Fisher DE. Tanning as a substance abuse. Commun Integr Biol. 2014 Oct; 7(5). PMID: 26842945.
    Citations:    
  49. Lee JH, Fisher DE. Melanocyte stem cells as potential therapeutics in skin disorders. Expert Opin Biol Ther. 2014 Nov; 14(11):1569-79. PMID: 25104310.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  50. Choi YS, Fisher DE. UV and melanoma: the TP53 link. Cell Res. 2014 Oct; 24(10):1157-8. PMID: 25033756.
    Citations: 2     Fields:    Translation:HumansAnimals
  51. Frederick DT, Salas Fragomeni RA, Schalck A, Ferreiro-Neira I, Hoff T, Cooper ZA, Haq R, Panka DJ, Kwong LN, Davies MA, Cusack JC, Flaherty KT, Fisher DE, Mier JW, Wargo JA, Sullivan RJ. Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics. PLoS One. 2014; 9(7):e101286. PMID: 24983357.
    Citations: 12     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  52. Fell GL, Robinson KC, Mao J, Woolf CJ, Fisher DE. Skin ß-endorphin mediates addiction to UV light. Cell. 2014 Jun 19; 157(7):1527-34. PMID: 24949966.
    Citations: 34     Fields:    Translation:HumansAnimals
  53. Sullivan RJ, Fisher DE. Understanding the biology of melanoma and therapeutic implications. Hematol Oncol Clin North Am. 2014 Jun; 28(3):437-53. PMID: 24880940.
    Citations: 12     Fields:    Translation:HumansCells
  54. Cooper ZA, Juneja VR, Sage PT, Frederick DT, Piris A, Mitra D, Lo JA, Hodi FS, Freeman GJ, Bosenberg MW, McMahon M, Flaherty KT, Fisher DE, Sharpe AH, Wargo JA. Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade. Cancer Immunol Res. 2014 Jul; 2(7):643-54. PMID: 24903021.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  55. Konieczkowski DJ, Johannessen CM, Abudayyeh O, Kim JW, Cooper ZA, Piris A, Frederick DT, Barzily-Rokni M, Straussman R, Haq R, Fisher DE, Mesirov JP, Hahn WC, Flaherty KT, Wargo JA, Tamayo P, Garraway LA. A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors. Cancer Discov. 2014 Jul; 4(7):816-27. PMID: 24771846.
    Citations: 97     Fields:    Translation:HumansCells
  56. Luo X, Mitra D, Sullivan RJ, Wittner BS, Kimura AM, Pan S, Hoang MP, Brannigan BW, Lawrence DP, Flaherty KT, Sequist LV, McMahon M, Bosenberg MW, Stott SL, Ting DT, Ramaswamy S, Toner M, Fisher DE, Maheswaran S, Haber DA. Isolation and molecular characterization of circulating melanoma cells. Cell Rep. 2014 May 08; 7(3):645-53. PMID: 24746818.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  57. Shtivelman E, Davies MQ, Hwu P, Yang J, Lotem M, Oren M, Flaherty KT, Fisher DE. Pathways and therapeutic targets in melanoma. Oncotarget. 2014 Apr 15; 5(7):1701-52. PMID: 24743024.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  58. Chen H, Weng QY, Fisher DE. UV signaling pathways within the skin. J Invest Dermatol. 2014 Aug; 134(8):2080-2085. PMID: 24759085.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  59. Haq R, Fisher DE, Widlund HR. Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation. Clin Cancer Res. 2014 May 01; 20(9):2257-63. PMID: 24610826.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  60. Lee JH, Chen H, Kolev V, Aull KH, Jung I, Wang J, Miyamoto S, Hosoi J, Mandinova A, Fisher DE. High-throughput, high-content screening for novel pigmentation regulators using a keratinocyte/melanocyte co-culture system. Exp Dermatol. 2014 Feb; 23(2):125-9. PMID: 24438532.
    Citations: 5     Fields:    Translation:AnimalsCells
  61. Dreze M, Calkins AS, Gálicza J, Echelman DJ, Schnorenberg MR, Fell GL, Iwai S, Fisher DE, Szüts D, Iglehart JD, Lazaro JB. Monitoring repair of UV-induced 6-4-photoproducts with a purified DDB2 protein complex. PLoS One. 2014; 9(1):e85896. PMID: 24489677.
    Citations: 2     Fields:    Translation:HumansCells
  62. Roider EM, Fisher DE. The impact of MITF on melanoma development: news from bench and bedside. J Invest Dermatol. 2014 Jan; 134(1):16-17. PMID: 24352080.
    Citations: 3     Fields:    Translation:HumansAnimals
  63. Levine D, Fisher DE. Current status of diagnostic and prognostic markers in melanoma. Methods Mol Biol. 2014; 1102:177-97. PMID: 24258980.
    Citations: 3     Fields:    Translation:Humans
  64. Praetorius C, Grill C, Stacey SN, Metcalf AM, Gorkin DU, Robinson KC, Van Otterloo E, Kim RS, Bergsteinsdottir K, Ogmundsdottir MH, Magnusdottir E, Mishra PJ, Davis SR, Guo T, Zaidi MR, Helgason AS, Sigurdsson MI, Meltzer PS, Merlino G, Petit V, Larue L, Loftus SK, Adams DR, Sobhiafshar U, Emre NC, Pavan WJ, Cornell R, Smith AG, McCallion AS, Fisher DE, Stefansson K, Sturm RA, Steingrimsson E. A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway. Cell. 2013 Nov 21; 155(5):1022-33. PMID: 24267888.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  65. Cooper ZA, Frederick DT, Juneja VR, Sullivan RJ, Lawrence DP, Piris A, Sharpe AH, Fisher DE, Flaherty KT, Wargo JA. BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes. Oncoimmunology. 2013 Oct 01; 2(10):e26615. PMID: 24251082.
    Citations: 30     
  66. Fisher DE, Geller AC. Disproportionate burden of melanoma mortality in young U.S. men: the possible role of biology and behavior. JAMA Dermatol. 2013 Aug; 149(8):903-4. PMID: 23804228.
    Citations: 3     Fields:    Translation:Humans
  67. Hodi FS, Corless CL, Giobbie-Hurder A, Fletcher JA, Zhu M, Marino-Enriquez A, Friedlander P, Gonzalez R, Weber JS, Gajewski TF, O'Day SJ, Kim KB, Lawrence D, Flaherty KT, Luke JJ, Collichio FA, Ernstoff MS, Heinrich MC, Beadling C, Zukotynski KA, Yap JT, Van den Abbeele AD, Demetri GD, Fisher DE. Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin. J Clin Oncol. 2013 Sep 10; 31(26):3182-90. PMID: 23775962.
    Citations: 81     Fields:    Translation:HumansCTClinical Trials
  68. Haq R, Fisher DE. Targeting melanoma by small molecules: challenges ahead. Pigment Cell Melanoma Res. 2013 Jul; 26(4):464-9. PMID: 23611259.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  69. Morgan AM, Lo J, Fisher DE. How does pheomelanin synthesis contribute to melanomagenesis?: Two distinct mechanisms could explain the carcinogenicity of pheomelanin synthesis. Bioessays. 2013 Aug; 35(8):672-6. PMID: 23650156.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  70. Fink EC, Fisher DE. BRAF and MC1R in melanoma: different in head and neck tumors? J Invest Dermatol. 2013 Apr; 133(4):878-80. PMID: 23486431.
    Citations:    Fields:    Translation:Humans
  71. Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe GC, Frederick DT, Hurley AD, Nellore A, Kung AL, Wargo JA, Song JS, Fisher DE, Arany Z, Widlund HR. Oncogenic BRAF regulates oxidative metabolism via PGC1a and MITF. Cancer Cell. 2013 Mar 18; 23(3):302-15. PMID: 23477830.
    Citations: 172     Fields:    Translation:HumansCells
  72. Haq R, Yokoyama S, Hawryluk EB, Jönsson GB, Frederick DT, McHenry K, Porter D, Tran TN, Love KT, Langer R, Anderson DG, Garraway LA, Duncan LM, Morton DL, Hoon DS, Wargo JA, Song JS, Fisher DE. BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):4321-6. PMID: 23447565.
    Citations: 60     Fields:    Translation:HumansCells
  73. Korman JB, Fisher DE. Developing melanoma therapeutics: overview and update. Wiley Interdiscip Rev Syst Biol Med. 2013 May-Jun; 5(3):257-71. PMID: 23408545.
    Citations: 4     Fields:    Translation:HumansCells
  74. Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, Mitra D, Boni A, Newton LP, Liu C, Peng W, Sullivan RJ, Lawrence DP, Hodi FS, Overwijk WW, Lizée G, Murphy GF, Hwu P, Flaherty KT, Fisher DE, Wargo JA. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res. 2013 Mar 01; 19(5):1225-31. PMID: 23307859.
    Citations: 207     Fields:    Translation:HumansCells
  75. Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrel C, Amos CI, Wei Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui R, Han J, Fisher DE, Arany Z. PGC-1 coactivators regulate MITF and the tanning response. Mol Cell. 2013 Jan 10; 49(1):145-57. PMID: 23201126.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  76. Mitra D, Luo X, Morgan A, Wang J, Hoang MP, Lo J, Guerrero CR, Lennerz JK, Mihm MC, Wargo JA, Robinson KC, Devi SP, Vanover JC, D'Orazio JA, McMahon M, Bosenberg MW, Haigis KM, Haber DA, Wang Y, Fisher DE. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature. 2012 Nov 15; 491(7424):449-53. PMID: 23123854.
    Citations: 101     Fields:    Translation:AnimalsCells
  77. Anghel SI, Correa-Rocha R, Correa-Rochal R, Budinska E, Boligan KF, Boliganl KF, Abraham S, Colombetti S, Fontao L, Mariotti A, Rimoldi D, Ghanem GE, Fisher DE, Lévy F, Delorenzi M, Piguet V. Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF. Pigment Cell Melanoma Res. 2012 Jul; 25(4):482-7. PMID: 22594792.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  78. Tsao H, Chin L, Garraway LA, Fisher DE. Melanoma: from mutations to medicine. Genes Dev. 2012 Jun 01; 26(11):1131-55. PMID: 22661227.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  79. Li J, Song JS, Bell RJ, Tran TN, Haq R, Liu H, Love KT, Langer R, Anderson DG, Larue L, Fisher DE. YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genet. 2012; 8(5):e1002688. PMID: 22570637.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  80. Flaherty KT, Hodi FS, Fisher DE. From genes to drugs: targeted strategies for melanoma. Nat Rev Cancer. 2012 Apr 05; 12(5):349-61. PMID: 22475929.
    Citations: 100     Fields:    Translation:HumansAnimals
  81. Kawakami A, Fisher DE. Key discoveries in melanocyte development. J Invest Dermatol. 2011 Nov 17; 131(E1):E2-4. PMID: 22094402.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  82. Yokoyama S, Woods SL, Boyle GM, Aoude LG, MacGregor S, Zismann V, Gartside M, Cust AE, Haq R, Harland M, Taylor JC, Duffy DL, Holohan K, Dutton-Regester K, Palmer JM, Bonazzi V, Stark MS, Symmons J, Law MH, Schmidt C, Lanagan C, O'Connor L, Holland EA, Schmid H, Maskiell JA, Jetann J, Ferguson M, Jenkins MA, Kefford RF, Giles GG, Armstrong BK, Aitken JF, Hopper JL, Whiteman DC, Pharoah PD, Easton DF, Dunning AM, Newton-Bishop JA, Montgomery GW, Martin NG, Mann GJ, Bishop DT, Tsao H, Trent JM, Fisher DE, Hayward NK, Brown KM. A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature. 2011 Nov 13; 480(7375):99-103. PMID: 22080950.
    Citations: 111     Fields:    Translation:HumansCells
  83. Janas MM, Khaled M, Schubert S, Bernstein JG, Golan D, Veguilla RA, Fisher DE, Shomron N, Levy C, Novina CD. Feed-forward microprocessing and splicing activities at a microRNA-containing intron. PLoS Genet. 2011 Oct; 7(10):e1002330. PMID: 22028668.
    Citations: 32     Fields:    Translation:HumansCells
  84. Feige E, Yokoyama S, Levy C, Khaled M, Igras V, Lin RJ, Lee S, Widlund HR, Granter SR, Kung AL, Fisher DE. Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):E924-33. PMID: 21949374.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  85. Mosquera JM, Dal Cin P, Mertz KD, Perner S, Davis IJ, Fisher DE, Rubin MA, Hirsch MS. Validation of a TFE3 break-apart FISH assay for Xp11.2 translocation renal cell carcinomas. Diagn Mol Pathol. 2011 Sep; 20(3):129-37. PMID: 21817901.
    Citations: 16     Fields:    Translation:HumansCells
  86. Zhao X, Fiske B, Kawakami A, Li J, Fisher DE. Regulation of MITF stability by the USP13 deubiquitinase. Nat Commun. 2011 Aug 02; 2:414. PMID: 21811243.
    Citations: 20     Fields:    Translation:HumansCells
  87. Haq R, Fisher DE. Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer. J Clin Oncol. 2011 Sep 01; 29(25):3474-82. PMID: 21670463.
    Citations: 39     Fields:    Translation:Humans
  88. Flaherty KT, Fisher DE. New strategies in metastatic melanoma: oncogene-defined taxonomy leads to therapeutic advances. Clin Cancer Res. 2011 Aug 01; 17(15):4922-8. PMID: 21670085.
    Citations: 14     Fields:    Translation:Humans
  89. Fisher DE. UV-tanning behavior: a problem that doesn't go away. Pigment Cell Melanoma Res. 2011 Aug; 24(4):724. PMID: 21535480.
    Citations:    Fields:    Translation:Humans
  90. Vidwans SJ, Flaherty KT, Fisher DE, Tenenbaum JM, Travers MD, Shrager J. A melanoma molecular disease model. PLoS One. 2011 Mar 30; 6(3):e18257. PMID: 21479172.
    Citations: 22     Fields:    Translation:HumansCells
  91. Mitra D, Robinson KC, Fisher DE. Melanoma and viagra: an unexpected connection. Pigment Cell Melanoma Res. 2011 Feb; 24(1):16-8. PMID: 21290790.
    Citations: 2     Fields:    Translation:HumansAnimals
  92. Levy C, Fisher DE. Dual roles of lineage restricted transcription factors: the case of MITF in melanocytes. Transcription. 2011 Jan-Feb; 2(1):19-22. PMID: 21326905.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  93. Liu JJ, Fisher DE. Lighting a path to pigmentation: mechanisms of MITF induction by UV. Pigment Cell Melanoma Res. 2010 Dec; 23(6):741-5. PMID: 20973930.
    Citations: 13     Fields:    Translation:HumansAnimals
  94. Levy C, Khaled M, Iliopoulos D, Janas MM, Schubert S, Pinner S, Chen PH, Li S, Fletcher AL, Yokoyama S, Scott KL, Garraway LA, Song JS, Granter SR, Turley SJ, Fisher DE, Novina CD. Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol Cell. 2010 Dec 10; 40(5):841-9. PMID: 21109473.
    Citations: 80     Fields:    Translation:HumansCells
  95. Ko JM, Fisher DE. A new era: melanoma genetics and therapeutics. J Pathol. 2011 Jan; 223(2):241-50. PMID: 21125678.
    Citations: 38     Fields:    Translation:HumansCells
  96. Khaled M, Levy C, Fisher DE. Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit. Genes Dev. 2010 Oct 15; 24(20):2276-81. PMID: 20952536.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  97. Fisher DE, James WD. Indoor tanning--science, behavior, and policy. N Engl J Med. 2010 Sep 02; 363(10):901-3. PMID: 20818900.
    Citations: 29     Fields:    Translation:HumansCells
  98. Garibyan L, Fisher DE. How sunlight causes melanoma. Curr Oncol Rep. 2010 Sep; 12(5):319-26. PMID: 20623386.
    Citations: 23     Fields:    Translation:Humans
  99. Park JM, Fisher DE. Testimony from the bedside: from Coley's toxins to targeted immunotherapy. Cancer Cell. 2010 Jul 13; 18(1):9-10. PMID: 20609349.
    Citations: 4     Fields:    
  100. Boni A, Cogdill AP, Dang P, Udayakumar D, Njauw CN, Sloss CM, Ferrone CR, Flaherty KT, Lawrence DP, Fisher DE, Tsao H, Wargo JA. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res. 2010 Jul 01; 70(13):5213-9. PMID: 20551059.
    Citations: 220     Fields:    Translation:HumansCells
  101. Levy C, Khaled M, Robinson KC, Veguilla RA, Chen PH, Yokoyama S, Makino E, Lu J, Larue L, Beermann F, Chin L, Bosenberg M, Song JS, Fisher DE. Lineage-specific transcriptional regulation of DICER by MITF in melanocytes. Cell. 2010 Jun 11; 141(6):994-1005. PMID: 20550935.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  102. Stewart RA, Sanda T, Widlund HR, Zhu S, Swanson KD, Hurley AD, Bentires-Alj M, Fisher DE, Kontaridis MI, Look AT, Neel BG. Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis. Dev Cell. 2010 May 18; 18(5):750-62. PMID: 20493809.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  103. Gordon PM, Fisher DE. Role for the proapoptotic factor BIM in mediating imatinib-induced apoptosis in a c-KIT-dependent gastrointestinal stromal tumor cell line. J Biol Chem. 2010 May 07; 285(19):14109-14. PMID: 20231287.
    Citations: 16     Fields:    Translation:HumansCells
  104. Jané-Valbuena J, Widlund HR, Perner S, Johnson LA, Dibner AC, Lin WM, Baker AC, Nazarian RM, Vijayendran KG, Sellers WR, Hahn WC, Duncan LM, Rubin MA, Fisher DE, Garraway LA. An oncogenic role for ETV1 in melanoma. Cancer Res. 2010 Mar 01; 70(5):2075-84. PMID: 20160028.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  105. Nishimura EK, Suzuki M, Igras V, Du J, Lonning S, Miyachi Y, Roes J, Beermann F, Fisher DE. Key roles for transforming growth factor beta in melanocyte stem cell maintenance. Cell Stem Cell. 2010 Feb 05; 6(2):130-40. PMID: 20144786.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  106. Davis IJ, McFadden AW, Zhang Y, Coxon A, Burgess TL, Wagner AJ, Fisher DE. Identification of the receptor tyrosine kinase c-Met and its ligand, hepatocyte growth factor, as therapeutic targets in clear cell sarcoma. Cancer Res. 2010 Jan 15; 70(2):639-45. PMID: 20068147.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  107. Fisher DE, Barnhill R, Hodi FS, Herlyn M, Merlino G, Medrano E, Bastian B, Landi MT, Landi TM, Sosman J. Melanoma from bench to bedside: meeting report from the 6th international melanoma congress. Pigment Cell Melanoma Res. 2010 Feb; 23(1):14-26. PMID: 20025711.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  108. Yokoyama S, Salma N, Fisher DE. MITF pathway mutations in melanoma. Pigment Cell Melanoma Res. 2009 Aug; 22(4):376-7. PMID: 19558635.
    Citations: 3     Fields:    Translation:HumansCells
  109. Scott KL, Kabbarah O, Liang MC, Ivanova E, Anagnostou V, Wu J, Dhakal S, Wu M, Chen S, Feinberg T, Huang J, Saci A, Widlund HR, Fisher DE, Xiao Y, Rimm DL, Protopopov A, Wong KK, Chin L. GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature. 2009 Jun 25; 459(7250):1085-90. PMID: 19553991.
    Citations: 118     Fields:    Translation:HumansAnimalsCells
  110. Fisher DE. Advances in melanoma. Preface. Hematol Oncol Clin North Am. 2009 Jun; 23(3):xiii-xiv. PMID: 19464591.
    Citations:    Fields:    Translation:Humans
  111. Mitra D, Fisher DE. Transcriptional regulation in melanoma. Hematol Oncol Clin North Am. 2009 Jun; 23(3):447-65, viii. PMID: 19464596.
    Citations: 12     Fields:    Translation:HumansCells
  112. Zhao X, Graves C, Ames SJ, Fisher DE, Spanjaard RA. Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10. Cancer Res. 2009 Jun 15; 69(12):5218-25. PMID: 19470764.
    Citations: 12     Fields:    Translation:HumansCells
  113. Schulman JM, Fisher DE. Indoor ultraviolet tanning and skin cancer: health risks and opportunities. Curr Opin Oncol. 2009 Mar; 21(2):144-9. PMID: 19532016.
    Citations: 18     Fields:    Translation:Humans
  114. Robinson KC, Fisher DE. Specification and loss of melanocyte stem cells. Semin Cell Dev Biol. 2009 Feb; 20(1):111-6. PMID: 19124082.
    Citations: 7     Fields:    Translation:AnimalsCells
  115. Jiang X, Zhou J, Yuen NK, Corless CL, Heinrich MC, Fletcher JA, Demetri GD, Widlund HR, Fisher DE, Hodi FS. Imatinib targeting of KIT-mutant oncoprotein in melanoma. Clin Cancer Res. 2008 Dec 01; 14(23):7726-32. PMID: 19047099.
    Citations: 41     Fields:    Translation:HumansCells
  116. Ozsolak F, Poling LL, Wang Z, Liu H, Liu XS, Roeder RG, Zhang X, Song JS, Fisher DE. Chromatin structure analyses identify miRNA promoters. Genes Dev. 2008 Nov 15; 22(22):3172-83. PMID: 19056895.
    Citations: 264     Fields:    Translation:HumansCells
  117. Osawa M, Fisher DE. Notch and melanocytes: diverse outcomes from a single signal. J Invest Dermatol. 2008 Nov; 128(11):2571-4. PMID: 18927539.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  118. Hodi FS, Fisher DE. Adoptive transfer of antigen-specific CD4+ T cells in the treatment of metastatic melanoma. Nat Clin Pract Oncol. 2008 Dec; 5(12):696-7. PMID: 18852719.
    Citations: 6     Fields:    
  119. Tran TT, Schulman J, Fisher DE. UV and pigmentation: molecular mechanisms and social controversies. Pigment Cell Melanoma Res. 2008 Oct; 21(5):509-16. PMID: 18821855.
    Citations: 20     Fields:    Translation:Humans
  120. Yokoyama S, Feige E, Poling LL, Levy C, Widlund HR, Khaled M, Kung AL, Fisher DE. Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage. Pigment Cell Melanoma Res. 2008 Aug; 21(4):457-63. PMID: 18627530.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  121. Hodi FS, Friedlander P, Corless CL, Heinrich MC, Mac Rae S, Kruse A, Jagannathan J, Van den Abbeele AD, Velazquez EF, Demetri GD, Fisher DE. Major response to imatinib mesylate in KIT-mutated melanoma. J Clin Oncol. 2008 Apr 20; 26(12):2046-51. PMID: 18421059.
    Citations: 116     Fields:    Translation:Humans
  122. Fisher DE, Medrano EE, McMahon M, Soengas MS, Schuchter L, Wolchok JD, Merlino G. Meeting report: fourth international congress of the Society for Melanoma Research. Pigment Cell Melanoma Res. 2008 Feb; 21(1):15-26. PMID: 18353140.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  123. Davis IJ, Fisher DE. MiT transcription factor associated malignancies in man. Cell Cycle. 2007 Jul 15; 6(14):1724-9. PMID: 17630504.
    Citations: 8     Fields:    Translation:HumansAnimals
  124. Cui R, Widlund HR, Feige E, Lin JY, Wilensky DL, Igras VE, D'Orazio J, Fung CY, Schanbacher CF, Granter SR, Fisher DE. Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell. 2007 Mar 09; 128(5):853-64. PMID: 17350573.
    Citations: 146     Fields:    Translation:HumansAnimalsCells
  125. Lin JY, Fisher DE. Melanocyte biology and skin pigmentation. Nature. 2007 Feb 22; 445(7130):843-50. PMID: 17314970.
    Citations: 190     Fields:    Translation:HumansAnimalsCells
  126. Tsuda M, Davis IJ, Argani P, Shukla N, McGill GG, Nagai M, Saito T, Laé M, Fisher DE, Ladanyi M. TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res. 2007 Feb 01; 67(3):919-29. PMID: 17283122.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  127. Ozsolak F, Song JS, Liu XS, Fisher DE. High-throughput mapping of the chromatin structure of human promoters. Nat Biotechnol. 2007 Feb; 25(2):244-8. PMID: 17220878.
    Citations: 153     Fields:    Translation:HumansCells
  128. D'Orazio JA, Nobuhisa T, Cui R, Arya M, Spry M, Wakamatsu K, Igras V, Kunisada T, Granter SR, Nishimura EK, Ito S, Fisher DE. Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature. 2006 Sep 21; 443(7109):340-4. PMID: 16988713.
    Citations: 84     Fields:    Translation:AnimalsCells
  129. Chin L, Garraway LA, Fisher DE. Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev. 2006 Aug 15; 20(16):2149-82. PMID: 16912270.
    Citations: 156     Fields:    Translation:HumansAnimalsCells
  130. Levy C, Khaled M, Fisher DE. MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol Med. 2006 Sep; 12(9):406-14. PMID: 16899407.
    Citations: 241     Fields:    Translation:HumansAnimalsCells
  131. Davis IJ, Kim JJ, Ozsolak F, Widlund HR, Rozenblatt-Rosen O, Granter SR, Du J, Fletcher JA, Denny CT, Lessnick SL, Linehan WM, Kung AL, Fisher DE. Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer Cell. 2006 Jun; 9(6):473-84. PMID: 16766266.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  132. McGill GG, Haq R, Nishimura EK, Fisher DE. c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 2006 Apr 14; 281(15):10365-73. PMID: 16455654.
    Citations: 51     Fields:    Translation:HumansCells
  133. Mukohara T, Civiello G, Davis IJ, Taffaro ML, Christensen J, Fisher DE, Johnson BE, Jänne PA. Inhibition of the met receptor in mesothelioma. Clin Cancer Res. 2005 Nov 15; 11(22):8122-30. PMID: 16299245.
    Citations: 28     Fields:    Translation:HumansCells
  134. Kim K, Kim JH, Lee J, Jin HM, Lee SH, Fisher DE, Kook H, Kim KK, Choi Y, Kim N. Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. J Biol Chem. 2005 Oct 21; 280(42):35209-16. PMID: 16109714.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  135. Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 2005 Jul 07; 436(7047):117-22. PMID: 16001072.
    Citations: 422     Fields:    Translation:HumansCells
  136. Hershey CL, Fisher DE. Genomic analysis of the Microphthalmia locus and identification of the MITF-J/Mitf-J isoform. Gene. 2005 Feb 28; 347(1):73-82. PMID: 15715979.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  137. Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD, Berghmans S, Mayhall EA, Traver D, Fletcher CD, Aster JC, Granter SR, Look AT, Lee C, Fisher DE, Zon LI. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol. 2005 Feb 08; 15(3):249-54. PMID: 15694309.
    Citations: 166     Fields:    Translation:AnimalsCells
  138. Argani P, Laé M, Hutchinson B, Reuter VE, Collins MH, Perentesis J, Tomaszewski JE, Brooks JS, Acs G, Bridge JA, Vargas SO, Davis IJ, Fisher DE, Ladanyi M. Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR. Am J Surg Pathol. 2005 Feb; 29(2):230-40. PMID: 15644781.
    Citations: 45     Fields:    Translation:HumansCells
  139. Nishimura EK, Granter SR, Fisher DE. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science. 2005 Feb 04; 307(5710):720-4. PMID: 15618488.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  140. Bentires-Alj M, Paez JG, David FS, Keilhack H, Halmos B, Naoki K, Maris JM, Richardson A, Bardelli A, Sugarbaker DJ, Richards WG, Du J, Girard L, Minna JD, Loh ML, Fisher DE, Velculescu VE, Vogelstein B, Meyerson M, Sellers WR, Neel BG. Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res. 2004 Dec 15; 64(24):8816-20. PMID: 15604238.
    Citations: 143     Fields:    Translation:HumansCells
  141. Du J, Widlund HR, Horstmann MA, Ramaswamy S, Ross K, Huber WE, Nishimura EK, Golub TR, Fisher DE. Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell. 2004 Dec; 6(6):565-76. PMID: 15607961.
    Citations: 109     Fields:    Translation:HumansCells
  142. Miller AJ, Levy C, Davis IJ, Razin E, Fisher DE. Sumoylation of MITF and its related family members TFE3 and TFEB. J Biol Chem. 2005 Jan 07; 280(1):146-55. PMID: 15507434.
    Citations: 38     Fields:    Translation:HumansCells
  143. Rowan S, Chen CM, Young TL, Fisher DE, Cepko CL. Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Development. 2004 Oct; 131(20):5139-52. PMID: 15459106.
    Citations: 50     Fields:    Translation:Animals
  144. Hershey CL, Fisher DE. Mitf and Tfe3: members of a b-HLH-ZIP transcription factor family essential for osteoclast development and function. Bone. 2004 Apr; 34(4):689-96. PMID: 15050900.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  145. Miller AJ, Du J, Rowan S, Hershey CL, Widlund HR, Fisher DE. Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma. Cancer Res. 2004 Jan 15; 64(2):509-16. PMID: 14744763.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  146. Chen D, Xu W, Bales E, Colmenares C, Conacci-Sorrell M, Ishii S, Stavnezer E, Campisi J, Fisher DE, Ben-Ze'ev A, Medrano EE. SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res. 2003 Oct 15; 63(20):6626-34. PMID: 14583455.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  147. Huber WE, Price ER, Widlund HR, Du J, Davis IJ, Wegner M, Fisher DE. A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes. J Biol Chem. 2003 Nov 14; 278(46):45224-30. PMID: 12944398.
    Citations: 22     Fields:    Translation:HumansCells
  148. Du J, Miller AJ, Widlund HR, Horstmann MA, Ramaswamy S, Fisher DE. MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma. Am J Pathol. 2003 Jul; 163(1):333-43. PMID: 12819038.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  149. Widlund HR, Fisher DE. Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival. Oncogene. 2003 May 19; 22(20):3035-41. PMID: 12789278.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  150. Davis IJ, Hsi BL, Arroyo JD, Vargas SO, Yeh YA, Motyckova G, Valencia P, Perez-Atayde AR, Argani P, Ladanyi M, Fletcher JA, Fisher DE. Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):6051-6. PMID: 12719541.
    Citations: 65     Fields:    Translation:HumansCells
  151. Baksh S, Widlund HR, Frazer-Abel AA, Du J, Fosmire S, Fisher DE, DeCaprio JA, Modiano JF, Burakoff SJ. NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell. 2002 Nov; 10(5):1071-81. PMID: 12453415.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  152. Widlund HR, Horstmann MA, Price ER, Cui J, Lessnick SL, Wu M, He X, Fisher DE. Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol. 2002 Sep 16; 158(6):1079-87. PMID: 12235125.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  153. Motyckova G, Fisher DE. Pycnodysostosis: role and regulation of cathepsin K in osteoclast function and human disease. Curr Mol Med. 2002 Aug; 2(5):407-21. PMID: 12125807.
    Citations: 28     Fields:    Translation:HumansCells
  154. McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK, Lin YL, Ramaswamy S, Avery W, Ding HF, Jordan SA, Jackson IJ, Korsmeyer SJ, Golub TR, Fisher DE. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell. 2002 Jun 14; 109(6):707-18. PMID: 12086670.
    Citations: 183     Fields:    Translation:HumansAnimalsCells
  155. Granter SR, Weilbaecher KN, Quigley C, Fisher DE. Role for microphthalmia transcription factor in the diagnosis of metastatic malignant melanoma. Appl Immunohistochem Mol Morphol. 2002 Mar; 10(1):47-51. PMID: 11893035.
    Citations: 10     Fields:    Translation:Humans
  156. Du J, Fisher DE. Identification of Aim-1 as the underwhite mouse mutant and its transcriptional regulation by MITF. J Biol Chem. 2002 Jan 04; 277(1):402-6. PMID: 11700328.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.