Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

profileJacob Stewart-Ornstein, Ph.D.

TitleResearch Fellow in Systems Biology (INT)
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Systems Biology WAB 536
200 Longwood Ave
Boston MA 02115
vCardDownload vCard (login for email)

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Stewart-Ornstein J, Cheng HWJ, Lahav G. Conservation and Divergence of p53 Oscillation Dynamics across Species. Cell Syst. 2017 Oct 25; 5(4):410-417.e4. PMID: 29055670.
    View in: PubMed
  2. Hafner A, Stewart-Ornstein J, Purvis JE, Forrester WC, Bulyk ML, Lahav G. p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics. Nat Struct Mol Biol. 2017 Oct; 24(10):840-847. PMID: 28825732.
    View in: PubMed
  3. Stewart-Ornstein J, Lahav G. p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM. Sci Signal. 2017 Apr 25; 10(476). PMID: 28442631.
    View in: PubMed
  4. Stewart-Ornstein J, Lahav G. Integrating genomic information and signaling dynamics for efficient cancer therapy. Curr Opin Syst Biol. 2017 Feb; 1:38-43. PMID: 28944311.
    View in: PubMed
  5. Stewart-Ornstein J, Chen S, Bhatnagar R, Weissman JS, El-Samad H. Model-guided optogenetic study of PKA signaling in budding yeast. Mol Biol Cell. 2017 Jan 01; 28(1):221-227. PMID: 28035051.
    View in: PubMed
  6. Stewart-Ornstein J, Lahav G. Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit. Cell Rep. 2016 Feb 23; 14(7):1800-1811. PMID: 26876176.
    View in: PubMed
  7. Lande-Diner L, Stewart-Ornstein J, Weitz CJ, Lahav G. Single-cell analysis of circadian dynamics in tissue explants. Mol Biol Cell. 2015 Nov 05; 26(22):3940-5. PMID: 26269583; PMCID: PMC4710227.
  8. Lipinski-Kruszka J, Stewart-Ornstein J, Chevalier MW, El-Samad H. Using dynamic noise propagation to infer causal regulatory relationships in biochemical networks. ACS Synth Biol. 2015 Mar 20; 4(3):258-64. PMID: 24967515; PMCID: PMC4384829.
  9. Stewart-Ornstein J, Nelson C, DeRisi J, Weissman JS, El-Samad H. Msn2 coordinates a stoichiometric gene expression program. Curr Biol. 2013 Dec 02; 23(23):2336-45. PMID: 24210615; PMCID: PMC4072881.
  10. Chen S, Harrigan P, Heineike B, Stewart-Ornstein J, El-Samad H. Building robust functionality in synthetic circuits using engineered feedback regulation. Curr Opin Biotechnol. 2013 Aug; 24(4):790-6. PMID: 23566378; PMCID: PMC3732497.
  11. Vidal SE, Pincus D, Stewart-Ornstein J, El-Samad H. Formation of subnuclear foci is a unique spatial behavior of mating MAPKs during hyperosmotic stress. Cell Rep. 2013 Feb 21; 3(2):328-34. PMID: 23416049; PMCID: PMC3616637.
  12. Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell. 2012 Nov 21; 151(5):1042-54. PMID: 23178123; PMCID: PMC3534965.
  13. Stewart-Ornstein J, Weissman JS, El-Samad H. Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae. Mol Cell. 2012 Feb 24; 45(4):483-93. PMID: 22365828; PMCID: PMC3327736.
  14. Stewart-Ornstein J, El-Samad H. Stochastic modeling of cellular networks. Methods Cell Biol. 2012; 110:111-37. PMID: 22482947.
    View in: PubMed
  15. Milias-Argeitis A, Summers S, Stewart-Ornstein J, Zuleta I, Pincus D, El-Samad H, Khammash M, Lygeros J. In silico feedback for in vivo regulation of a gene expression circuit. Nat Biotechnol. 2011 Nov 06; 29(12):1114-6. PMID: 22057053; PMCID: PMC4565053.
  16. Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman JS. A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods. 2008 Aug; 5(8):711-8. PMID: 18622397; PMCID: PMC2756093.
  17. Stewart-Ornstein J, Hitchcock AP, Hernández Cruz D, Henklein P, Overhage J, Hilpert K, Hale JD, Hancock RE. Using intrinsic X-ray absorption spectral differences to identify and map peptides and proteins. J Phys Chem B. 2007 Jul 05; 111(26):7691-9. PMID: 17559260.
    View in: PubMed
  18. Guay D, Stewart-Ornstein J, Zhang X, Hitchcock AP. In situ spatial and time-resolved studies of electrochemical reactions by scanning transmission X-ray microscopy. Anal Chem. 2005 Jun 01; 77(11):3479-87. PMID: 15924378.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at For faculty personal and demographic information, contact HMS Office for Faculty Affairs at
Stewart-Ornstein's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
Co-Authors Expand Description
Similar People Expand Description
Same Department Expand Description