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Joren Christian Madsen, D.Phil., M.D.

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Mentoring
Available: 05/21/14, Expires: 05/30/19

Tolerance of kidney allografts has been achieved in non-human primates (NHPs) and in humans using a combination of nonmyeloablative conditioning and donor bone marrow transplantation (DMBT) that results in transient donor hematopoietic chimerism. However, this procedure fails to induce tolerance in NHP recipients of heart allografts. It is well known that some organs, such as kidney and liver, are immune-privileged and tolerance-prone, while others, such as heart and lung, are tolerance-resistant. In earlier studies using MHC inbred miniature swine, we took advantage of the tolerogenicity of kidney allografts and, through donor kidney cotransplantation, achieved long-term tolerance of heart allografts which, if transplanted alone, are rejected acutely. Mechanistic studies in swine showed that kidney allografts were able to confer tolerance upon co-transplanted hearts by promoting the expansion of regulatory T cells (Tregs).

Recently, by combining our mixed-chimerism protocol that induces transient donor chimerism with donor kidney cotransplantation, we have succeeded in achieving long-term tolerance of MHC-mismatched heart allografts. Importantly, every recipient that successfully completed its tolerance protocol achieved indefinite allograft survival without evidence of cardiac allograft vasculopathy (CAV). These results are the first to demonstrate tolerance induction in NHP heart allograft recipients and the first to show that long term unresponsiveness to a tolerant-resistant organ can be achieved without durable donor chimerism.

Given our findings in swine and NHPs demonstrating that the tolerogenicity of kidney allografts is based upon regulatory mechanisms, we hypothesize that amplifying the contributions of host Tregs while limiting the deleterious activity of memory T cells (Tmems) in NHP heart allograft recipients undergoing mixed chimerism conditioning will achieve long-term tolerance without the need for kidney cotransplantation. To test this hypothesis, we will determine whether two clinically relevant strategies known to suppress memory T cell immunity while enhancing the in vivo contributions of Tregs will successfully substitute for the kidney cotransplantation and induce tolerance of isolated heart allograft. The successful completion of these studies could yield tolerance protocols ready for immediate evaluation in human heart-alone recipients.

Student Role: He/she will participate in the design, execution and analysis of each experiment. Furthermore, they will engage in large animal surgery and postoperative care. A perfect opportunity for those interested in a career in surgery.

The Role of the Renal Tubular Epithelial Cell in Kidney-Induced Cardiac Allograft Tolerance
Summer, 06/11/12 - 08/17/12

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01AI136816 (MADSEN, JOREN C) May 1, 2018 - Apr 30, 2023
    NIH/NIAID
    Targeting Inflammation and Alloimmunity in Heart Transplant Recipients with Tocilizumab
    Role: Principal Investigator
  2. U01AI131470 (MADSEN, JOREN C) Jun 1, 2017 - May 31, 2022
    NIH/NIAID
    Mixed chimerism induced tolerance in heart recipients requires donor kidney cotransplantation
    Role: Principal Investigator
  3. R34AI125058 (MADSEN, JOREN C) Aug 15, 2016 - Jul 31, 2017
    NIH/NIAID
    Targeting Inflammation and Alloimmunity in Heart Transplant Recipients with Tocilizumab
    Role: Principal Investigator
  4. P01AI123086 (MADSEN, JOREN C) Aug 5, 2016 - Jul 31, 2021
    NIH/NIAID
    Mechanisms of Kidney-Induced Cardiac Allograft Tolerance
    Role: Principal Investigator
  5. U01AI094374 (MADSEN, JOREN C) Sep 1, 2010 - May 31, 2017
    NIH/NIAID
    Tolerance Strategies in Non-Human Primate Cardiac Allograft Recipients
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Robinson KA, Orent W, Madsen JC, Benichou G. Maintaining T cell tolerance of alloantigens: Lessons from animal studies. Am J Transplant. 2018 Aug; 18(8):1843-1856. PMID: 29939471.
    View in: PubMed
  2. Wang Z, Louras NJ, Lellouch AG, Pratts SG, Zhang H, Wang H, Huang CA, Cetrulo CL, Madsen JC, Sachs DH, Wang Z. Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates. Mol Oncol. 2018 Aug; 12(8):1374-1382. PMID: 29873181.
    View in: PubMed
  3. Warnecke G, Van Raemdonck D, Smith MA, Massard G, Kukreja J, Rea F, Loor G, De Robertis F, Nagendran J, Dhital KK, Moradiellos Díez FJ, Knosalla C, Bermudez CA, Tsui S, McCurry K, Wang IW, Deuse T, Lesèche G, Thomas P, Tudorache I, Kühn C, Avsar M, Wiegmann B, Sommer W, Neyrinck A, Schiavon M, Calabrese F, Santelmo N, Olland A, Falcoz PE, Simon AR, Varela A, Madsen JC, Hertz M, Haverich A, Ardehali A. Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study. Lancet Respir Med. 2018 05; 6(5):357-367. PMID: 29650408.
    View in: PubMed
  4. Michel SG, Madariaga MLL, LaMuraglia GM, Villani V, Sekijima M, Farkash EA, Colvin RB, Sachs DH, Yamada K, Rosengard BR, Allan JS, Madsen JC. The effects of brain death and ischemia on tolerance induction are organ-specific. Am J Transplant. 2018 May; 18(5):1262-1269. PMID: 29377632.
    View in: PubMed
  5. Sasaki H, Oura T, Spitzer TR, Chen YB, Madsen JC, Allan J, Sachs DH, Cosimi AB, Kawai T. Preclinical and clinical studies for transplant tolerance via the mixed chimerism approach. Hum Immunol. 2018 May; 79(5):258-265. PMID: 29175110.
    View in: PubMed
  6. Madsen JC. Advances in the immunology of heart transplantation. J Heart Lung Transplant. 2017 Dec; 36(12):1299-1305. PMID: 29173391.
    View in: PubMed
  7. Chatterjee D, Moore C, Gao B, Clerkin KJ, See SB, Shaked D, Rogers K, Nunez S, Veras Y, Addonizio L, Givertz MM, Naka Y, Mancini D, Vasilescu R, Marboe C, Restaino S, Madsen JC, Zorn E. Prevalence of polyreactive innate clones among graft--infiltrating B cells in human cardiac allograft vasculopathy. J Heart Lung Transplant. 2018 Mar; 37(3):385-393. PMID: 29055600.
    View in: PubMed
  8. Wang Z, Zheng Q, Zhang H, Bronson RT, Madsen JC, Sachs DH, Huang CA, Wang Z. Ontak-like human IL-2 fusion toxin. J Immunol Methods. 2017 09; 448:51-58. PMID: 28551309.
    View in: PubMed
  9. Zheng Q, Wang Z, Zhang H, Huang Q, Madsen JC, Sachs DH, Huang CA, Wang Z. Diphtheria toxin-based anti-human CD19 immunotoxin for targeting human CD19+ tumors. Mol Oncol. 2017 05; 11(5):584-594. PMID: 28306193.
    View in: PubMed
  10. Purroy C, Fairchild RL, Tanaka T, Baldwin WM, Manrique J, Madsen JC, Colvin RB, Alessandrini A, Blazar BR, Fribourg M, Donadei C, Maggiore U, Heeger PS, Cravedi P. Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival. J Am Soc Nephrol. 2017 Aug; 28(8):2377-2392. PMID: 28302753.
    View in: PubMed
  11. Nuñez S, Moore C, Gao B, Rogers K, Hidalgo Y, Del Nido PJ, Restaino S, Naka Y, Bhagat G, Madsen JC, Bono MR, Zorn E. The human thymus perivascular space is a functional niche for viral-specific plasma cells. Sci Immunol. 2016 Dec; 1(6). PMID: 28459117.
    View in: PubMed
  12. Wang Z, Navarro-Alvarez N, Shah JA, Zhang H, Huang Q, Zheng Q, Madsen JC, Sachs DH, Huang CA, Wang Z. Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin. Vet Immunol Immunopathol. 2016 Dec; 182:150-158. PMID: 27863545.
    View in: PubMed
  13. Hotta K, Aoyama A, Oura T, Yamada Y, Tonsho M, Huh KH, Kawai K, Schoenfeld D, Allan JS, Madsen JC, Benichou G, Smith RN, Colvin RB, Sachs DH, Cosimi AB, Kawai T. Induced regulatory T cells in allograft tolerance via transient mixed chimerism. JCI Insight. 2016 Jul 07; 1(10). PMID: 27446989.
    View in: PubMed
  14. Sihag S, Haas MS, Kim KM, Guerrero JL, Beaudoin J, Alicot EM, Schuerpf F, Gottschall JD, Puro RJ, Madsen JC, Sachs DH, Newman W, Carroll MC, Allan JS. Natural IgM Blockade Limits Infarct Expansion and Left Ventricular Dysfunction in a Swine Myocardial Infarct Model. Circ Cardiovasc Interv. 2016 Jan; 9(1):e002547. PMID: 26671971; PMCID: PMC4687758 [Available on 01/01/17].
  15. Wang Z, Pratts SG, Zhang H, Spencer PJ, Yu R, Tonsho M, Shah JA, Tanabe T, Powell HR, Huang CA, Madsen JC, Sachs DH, Wang Z. Treg depletion in non-human primates using a novel diphtheria toxin-based anti-human CCR4 immunotoxin. Mol Oncol. 2016 Apr; 10(4):553-65. PMID: 26643572; PMCID: PMC4826841 [Available on 04/01/17].
  16. Alexander SI, Madsen JC. Organ Transplant Tolerance for Children; in Sight for Some. J Pediatr. 2016 Jan; 168:232-5. PMID: 26581495.
    View in: PubMed
  17. La Muraglia GM, O'Neil MJ, Madariaga ML, Michel SG, Mordecai KS, Allan JS, Madsen JC, Hanekamp IM, Preffer FI. A novel approach to measuring cell-mediated lympholysis using quantitative flow and imaging cytometry. J Immunol Methods. 2015 Dec; 427:85-93. PMID: 26516062.
    View in: PubMed
  18. Madariaga ML, Spencer PJ, Michel SG, La Muraglia GM, O'Neil MJ, Mannon EC, Leblang C, Rosales IA, Colvin RB, Sachs DH, Allan JS, Madsen JC. Effects of Lung Cotransplantation on Cardiac Allograft Tolerance Across a Full Major Histocompatibility Complex Barrier in Miniature Swine. Am J Transplant. 2016 Mar; 16(3):979-86. PMID: 26469344; PMCID: PMC5010442 [Available on 03/01/17].
  19. Michel SG, La Muraglia GM, Madariaga ML, Titus JS, Selig MK, Farkash EA, Allan JS, Anderson LM, Madsen JC. Twelve-Hour Hypothermic Machine Perfusion for Donor Heart Preservation Leads to Improved Ultrastructural Characteristics Compared to Conventional Cold Storage. Ann Transplant. 2015 Aug 11; 20:461-8. PMID: 26259549.
    View in: PubMed
  20. Matthews KA, Tonsho M, Madsen JC. New-Onset Diabetes Mellitus After Transplantation in a Cynomolgus Macaque (Macaca fasicularis). Comp Med. 2015 Aug; 65(4):352-6. PMID: 26310466; PMCID: PMC4549682.
  21. Madariaga MLL, Shanmugarajah K, Michel SG, Villani V, Muraglia GM, Torabi R, Leonard DA, Randolph MA, Colvin RB, Yamada K, Madsen JC, Cetrulo CL, Sachs DH. Immunomodulatory Strategies Directed Toward Tolerance of Vascularized Composite Allografts. Transplantation. 2015 Aug; 99(8):1590-1597. PMID: 25757218; PMCID: PMC4551576.
  22. Madariaga ML, Kreisel D, Madsen JC. Organ-specific differences in achieving tolerance. Curr Opin Organ Transplant. 2015 Aug; 20(4):392-9. PMID: 26147678; PMCID: PMC4523268.
  23. Yamada Y, Nadazdin O, Boskovic S, Lee S, Zorn E, Smith RN, Colvin RB, Madsen JC, Cosimi AB, Kawai T, Benichou G. Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced via Mixed Hematopoietic Chimerism in Monkeys. Am J Transplant. 2015 Dec; 15(12):3055-66. PMID: 26190648; PMCID: PMC4654979.
  24. Madariaga ML, Michel SG, La Muraglia GM, Sihag S, Leonard DA, Farkash EA, Colvin RB, Cetrulo CL, Huang CA, Sachs DH, Madsen JC, Allan JS. Recipient-matching of Passenger Leukocytes Prolongs Survival of Donor Lung Allografts in Miniature Swine. Transplantation. 2015 Jul; 99(7):1372-8. PMID: 25757217; PMCID: PMC4494890.
  25. Wang Z, Wei M, Zhang H, Chen H, Germana S, Huang CA, Madsen JC, Sachs DH, Wang Z. Diphtheria-toxin based anti-human CCR4 immunotoxin for targeting human CCR4(+) cells in vivo. Mol Oncol. 2015 Aug; 9(7):1458-70. PMID: 25958791.
    View in: PubMed
  26. Tonsho M, Lee S, Aoyama A, Boskovic S, Nadazdin O, Capetta K, Smith RN, Colvin RB, Sachs DH, Cosimi AB, Kawai T, Madsen JC, Benichou G, Allan JS. Tolerance of Lung Allografts Achieved in Nonhuman Primates via Mixed Hematopoietic Chimerism. Am J Transplant. 2015 Aug; 15(8):2231-9. PMID: 25904524; PMCID: PMC4569127.
  27. Madariaga ML, Michel SG, La Muraglia GM, Sekijima M, Villani V, Leonard DA, Powell HJ, Kurtz JM, Farkash EA, Colvin RB, Allan JS, Cetrulo CL, Huang CA, Sachs DH, Yamada K, Madsen JC. Kidney-induced cardiac allograft tolerance in miniature swine is dependent on MHC-matching of donor cardiac and renal parenchyma. Am J Transplant. 2015 Jun; 15(6):1580-90. PMID: 25824550; PMCID: PMC4565499.
  28. Aoyama A, Tonsho M, Ng CY, Lee S, Millington T, Nadazdin O, Wain JC, Cosimi AB, Sachs DH, Smith RN, Colvin RB, Kawai T, Madsen JC, Benichou G, Allan JS. Long-term lung transplantation in nonhuman primates. Am J Transplant. 2015 May; 15(5):1415-20. PMID: 25772308; PMCID: PMC4564890.
  29. Yamada Y, Ochiai T, Boskovic S, Nadazdin O, Oura T, Schoenfeld D, Cappetta K, Smith RN, Colvin RB, Madsen JC, Sachs DH, Benichou G, Cosimi AB, Kawai T. Use of CTLA4Ig for induction of mixed chimerism and renal allograft tolerance in nonhuman primates. Am J Transplant. 2014 Dec; 14(12):2704-12. PMID: 25394378; PMCID: PMC4236265.
  30. Hirohashi T, Chase CM, DellaPelle P, Sebastian D, Farkesh E, Colvin RB, Russell PS, Alessandrini A, Madsen JC. Depletion of T regulatory cells promotes natural killer cell-mediated cardiac allograft vasculopathy. Transplantation. 2014 Oct 27; 98(8):828-34. PMID: 25321164; PMCID: PMC4203423.
  31. Wei M, Marino J, Trowell A, Zhang H, Stromp Peraino J, Rajasekera PV, Madsen JC, Sachs DH, Huang CA, Benichou G, Wang Z. Diphtheria toxin-based recombinant murine IL-2 fusion toxin for depleting murine regulatory T cells in vivo. Protein Eng Des Sel. 2014 Sep; 27(9):289-95. PMID: 25147093.
    View in: PubMed
  32. Shinoda K, Akiyoshi T, Chase CM, Farkash EA, Ndishabandi DK, Raczek CM, Sebastian DP, Pelle PD, Russell PS, Madsen JC, Colvin RB, Alessandrini A. Depletion of foxp3(+) T cells abrogates tolerance of skin and heart allografts in murine mixed chimeras without the loss of mixed chimerism. Am J Transplant. 2014 Oct; 14(10):2263-2274. PMID: 25155089; PMCID: PMC4523231.
  33. Michel SG, La Muraglia GM, Madariaga ML, Titus JS, Selig MK, Farkash EA, Allan JS, Anderson LM, Madsen JC. Preservation of donor hearts using hypothermic oxygenated perfusion. Ann Transplant. 2014 Aug 20; 19:409-16. PMID: 25139381; PMCID: PMC4548302.
  34. Kawai T, Leventhal J, Madsen JC, Strober S, Turka LA, Wood KJ. Tolerance: one transplant for life. Transplantation. 2014 Jul 27; 98(2):117-21. PMID: 24926829; PMCID: PMC4101034.
  35. Tonsho M, Michel S, Ahmed Z, Alessandrini A, Madsen JC. Heart transplantation: challenges facing the field. Cold Spring Harb Perspect Med. 2014 May 01; 4(5). PMID: 24789875; PMCID: PMC3996379.
  36. Peraino JS, Zhang H, Rajasekera PV, Wei M, Madsen JC, Sachs DH, Huang CA, Wang Z. Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25(+) cells. J Immunol Methods. 2014 Mar; 405:57-66. PMID: 24462799; PMCID: PMC4120078.
  37. Fitzsimons MG, Ichinose F, Vagefi PA, Markmann JF, Pierce ET, MacGillivray TE, Hertl M, Gauran C, Madsen JC, Baker J. Successful right ventricular mechanical support after combined heart-liver transplantation. J Cardiothorac Vasc Anesth. 2014 Dec; 28(6):1583-5. PMID: 24462515.
    View in: PubMed
  38. Gray Gilstrap L, Niehaus E, Malhotra R, Ton VK, Watts J, Seldin DC, Madsen JC, Semigran MJ. Predictors of survival to orthotopic heart transplant in patients with light chain amyloidosis. J Heart Lung Transplant. 2014 Feb; 33(2):149-56. PMID: 24200511; PMCID: PMC3946702.
  39. Madariaga ML, Michel SG, Tasaki M, Villani V, La Muraglia GM, Sihag S, Gottschall J, Farkash EA, Shimizu A, Allan JS, Sachs DH, Yamada K, Madsen JC. Induction of cardiac allograft tolerance across a full MHC barrier in miniature swine by donor kidney cotransplantation. Am J Transplant. 2013 Oct; 13(10):2558-66. PMID: 24033991; PMCID: PMC3920984.
  40. Akiyoshi T, Hirohashi T, Alessandrini A, Chase CM, Farkash EA, Neal Smith R, Madsen JC, Russell PS, Colvin RB. Role of complement and NK cells in antibody mediated rejection. Hum Immunol. 2012 Dec; 73(12):1226-32. PMID: 22850181; PMCID: PMC3728655.
  41. Aoyama A, Klarin D, Yamada Y, Boskovic S, Nadazdin O, Kawai K, Schoenfeld D, Madsen JC, Cosimi AB, Benichou G, Kawai T. Low-dose IL-2 for In vivo expansion of CD4+ and CD8+ regulatory T cells in nonhuman primates. Am J Transplant. 2012 Sep; 12(9):2532-7. PMID: 22682297; PMCID: PMC3429727.
  42. Yamada Y, Aoyama A, Tocco G, Boskovic S, Nadazdin O, Alessandrini A, Madsen JC, Cosimi AB, Benichou G, Kawai T. Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates. J Immunol. 2012 Jun 15; 188(12):6063-70. PMID: 22586034; PMCID: PMC3370077.
  43. Benichou G, Tonsho M, Tocco G, Nadazdin O, Madsen JC. Innate immunity and resistance to tolerogenesis in allotransplantation. Front Immunol. 2012; 3:73. PMID: 22566954; PMCID: PMC3342343.
  44. Millington T, Koulmanda M, Ng C, Boskovic S, Nadazdin OM, Benichou G, Zheng XX, Strom TB, Madsen JC. Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates. J Heart Lung Transplant. 2012 Apr; 31(4):427-35. PMID: 22366291; PMCID: PMC3731051.
  45. Liu W, Xiao X, Demirci G, Madsen J, Li XC. Innate NK cells and macrophages recognize and reject allogeneic nonself in vivo via different mechanisms. J Immunol. 2012 Mar 15; 188(6):2703-11. PMID: 22327074; PMCID: PMC3298083.
  46. Meltzer AJ, Veillette GR, Aoyama A, Kim KM, Cochrane ME, Wain JC, Madsen JC, Sachs DH, Rosengard BR, Allan JS. Donor brain death inhibits tolerance induction in miniature swine recipients of fully MHC-disparate pulmonary allografts. Am J Transplant. 2012 May; 12(5):1290-5. PMID: 22300400; PMCID: PMC3648993.
  47. Hirohashi T, Chase CM, Della Pelle P, Sebastian D, Alessandrini A, Madsen JC, Russell PS, Colvin RB. A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody. Am J Transplant. 2012 Feb; 12(2):313-21. PMID: 22070565; PMCID: PMC3667648.
  48. Yamada Y, Boskovic S, Aoyama A, Murakami T, Putheti P, Smith RN, Ochiai T, Nadazdin O, Koyama I, Boenisch O, Najafian N, Bhasin MK, Colvin RB, Madsen JC, Strom TB, Sachs DH, Benichou G, Cosimi AB, Kawai T. Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates. Am J Transplant. 2012 Feb; 12(2):330-40. PMID: 22053723; PMCID: PMC3268945.
  49. Nadazdin O, Boskovic S, Wee SL, Sogawa H, Koyama I, Colvin RB, Smith RN, Tocco G, O'Connor DH, Karl JA, Madsen JC, Sachs DH, Kawai T, Cosimi AB, Benichou G. Contributions of direct and indirect alloresponses to chronic rejection of kidney allografts in nonhuman primates. J Immunol. 2011 Nov 01; 187(9):4589-97. PMID: 21957140; PMCID: PMC3197941.
  50. Song JJ, Kim SS, Liu Z, Madsen JC, Mathisen DJ, Vacanti JP, Ott HC. Enhanced in vivo function of bioartificial lungs in rats. Ann Thorac Surg. 2011 Sep; 92(3):998-1005; discussion 1005-6. PMID: 21871290.
    View in: PubMed
  51. Veillette GR, Sahara H, Meltzer AJ, Weiss MJ, Iwamoto Y, Kim KM, Rosengard BR, Allan JS, Houser SL, Sachs DH, Benichou G, Madsen JC. Autoimmune sensitization to cardiac myosin leads to acute rejection of cardiac allografts in miniature swine. Transplantation. 2011 Jun 15; 91(11):1187-91. PMID: 21512437; PMCID: PMC3232060.
  52. Nadazdin O, Boskovic S, Murakami T, Tocco G, Smith RN, Colvin RB, Sachs DH, Allan J, Madsen JC, Kawai T, Cosimi AB, Benichou G. Host alloreactive memory T cells influence tolerance to kidney allografts in nonhuman primates. Sci Transl Med. 2011 Jun 08; 3(86):86ra51. PMID: 21653831; PMCID: PMC3261229.
  53. Russell PS, Chase CM, Madsen JC, Hirohashi T, Cornell LD, Sproule TJ, Colvin RB, Roopenian DC. Coronary artery disease from isolated non-H2-determined incompatibilities in transplanted mouse hearts. Transplantation. 2011 Apr 27; 91(8):847-52. PMID: 21378606; PMCID: PMC3083027.
  54. Miyajima M, Chase CM, Alessandrini A, Farkash EA, Della Pelle P, Benichou G, Graham JA, Madsen JC, Russell PS, Colvin RB. Early acceptance of renal allografts in mice is dependent on foxp3(+) cells. Am J Pathol. 2011 Apr; 178(4):1635-45. PMID: 21435448; PMCID: PMC3078464.
  55. Benichou G, Yamada Y, Aoyama A, Madsen JC. Natural killer cells in rejection and tolerance of solid organ allografts. Curr Opin Organ Transplant. 2011 Feb; 16(1):47-53. PMID: 21157342; PMCID: PMC3168956.
  56. Millington TM, Madsen JC. Innate immunity and cardiac allograft rejection. Kidney Int Suppl. 2010 Dec; (119):S18-21. PMID: 21116311; PMCID: PMC3261228.
  57. Dey BR, Chung SS, Spitzer TR, Zheng H, Macgillivray TE, Seldin DC, McAfee S, Ballen K, Attar E, Wang T, Shin J, Newton-Cheh C, Moore S, Sanchorawala V, Skinner M, Madsen JC, Semigran MJ. Cardiac transplantation followed by dose-intensive melphalan and autologous stem-cell transplantation for light chain amyloidosis and heart failure. Transplantation. 2010 Oct 27; 90(8):905-11. PMID: 20733534; PMCID: PMC2964067.
  58. Evans RW, Applegate WH, Briscoe DM, Cohen DJ, Rorick CC, Murphy BT, Madsen JC. Cost-related immunosuppressive medication nonadherence among kidney transplant recipients. Clin J Am Soc Nephrol. 2010 Dec; 5(12):2323-8. PMID: 20847093; PMCID: PMC2994095.
  59. Graham JA, Fray M, de Haseth S, Lee KM, Lian MM, Chase CM, Madsen JC, Markmann J, Benichou G, Colvin RB, Cosimi AB, Deng S, Kim J, Alessandrini A. Suppressive regulatory T cell activity is potentiated by glycogen synthase kinase 3{beta} inhibition. J Biol Chem. 2010 Oct 22; 285(43):32852-9. PMID: 20729209; PMCID: PMC2963417.
  60. Mehra MR, Crespo-Leiro MG, Dipchand A, Ensminger SM, Hiemann NE, Kobashigawa JA, Madsen J, Parameshwar J, Starling RC, Uber PA. International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy-2010. J Heart Lung Transplant. 2010 Jul; 29(7):717-27. PMID: 20620917.
    View in: PubMed
  61. Nadazdin O, Boskovic S, Murakami T, O'Connor DH, Wiseman RW, Karl JA, Tuscher JJ, Sachs DH, Madsen JC, Tocco G, Kawai T, Cosimi AB, Benichou G. Phenotype, distribution and alloreactive properties of memory T cells from cynomolgus monkeys. Am J Transplant. 2010 Jun; 10(6):1375-84. PMID: 20486921; PMCID: PMC2893326.
  62. Nadazdin O, Abrahamian G, Boskovic S, Smith RN, Schoenfeld DA, Madsen JC, Colvin RB, Sachs DH, Cosimi AB, Kawai T. Stem cell mobilization and collection for induction of mixed chimerism and renal allograft tolerance in cynomolgus monkeys. J Surg Res. 2011 Jun 15; 168(2):294-300. PMID: 20605588; PMCID: PMC2952058.
  63. Hirohashi T, Uehara S, Chase CM, DellaPelle P, Madsen JC, Russell PS, Colvin RB. Complement independent antibody-mediated endarteritis and transplant arteriopathy in mice. Am J Transplant. 2010 Mar; 10(3):510-7. PMID: 20055805; PMCID: PMC3252386.
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  117. Mezrich JD, Haller GW, Arn JS, Houser SL, Madsen JC, Sachs DH. Histocompatible miniature swine: an inbred large-animal model. Transplantation. 2003 Mar 27; 75(6):904-7. PMID: 12660524.
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  118. Mezrich JD, Yamada K, Lee RS, Mawulawde K, Benjamin LC, Schwarze ML, Maloney ME, Amoah HC, Houser SL, Sachs DH, Madsen JC. Induction of tolerance to heart transplants by simultaneous cotransplantation of donor kidneys may depend on a radiation-sensitive renal cell population. Transplantation(Rapid Communication). 2003; 76:625-31.
  119. Mezrich JD, Kesselheim JA, Johnston DR, Yamada K, Sachs DH, Madsen JC. The role of regulatory T cells in miniature swine rendered tolerant to cardiac allografts. American Journal of Transplantation. 2003; 3:1107-15.
  120. Mezrich JD, Haller GW, Arn JS, Houser SL, Madsen JC, Sachs DH. Histocompatible miniature swine: an inbred large animal model . Transplantation. 2003; 75:904-7.
  121. Akins CW, Hilgenberg AD, Vlahakes GJ, MacGillivray TE, Torchiana DF, Madsen JC. Results of bioprosthetic versus mechanical aortic valve replacement performed with concomitant coronary artery bypass grafting. Ann Thorac Surg. 2002 Oct; 74(4):1098-106. PMID: 12400752.
    View in: PubMed
  122. Ohuchi H, Madsen JC, Neragi-Miandoab S, Vlahakes GJ. A novel technique for en bloc, vascularized, composite thymic, and cardiac co-transplantation1. Transplantation. 2002 Aug 15; 74(3):403-5. PMID: 12177621.
    View in: PubMed
  123. Kawai T, Cosimi AB, Wee SL, Houser S, Andrews D, Sogawa H, Phelan J, Boskovic S, Nadazdin O, Abrahamian G, Colvin RB, Sach DH, Madsen JC. Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys. Transplantation. 2002 Jun 15; 73(11):1757-64. PMID: 12084998.
    View in: PubMed
  124. Mezrich JD, Sachs DH, Madsen JC. Combined heart and kidney transplantation: are two organs better than one? J Heart Lung Transplant. 2002 Jun; 21(6):714-6. PMID: 12057709.
    View in: PubMed
  125. Allan JS, Madsen JC. Recent advances in the immunology of chronic rejection. Curr Opin Nephrol Hypertens. 2002 May; 11(3):315-21. PMID: 11981262.
    View in: PubMed
  126. Johnston DR, Sayegh MH, Madsen JC. Overcoming cardiac allograft vasculopathy (CAV) by inducing tolerance. Front Biosci. 2002 May 01; 7:e116-8. PMID: 11991839.
    View in: PubMed
  127. Allan JS, Wain JC, Schwarze ML, Houser SL, Benjamin LC, Madsen JC, Sachs DH. Modeling chronic lung allograft rejection in miniature swine. Transplantation. 2002 Feb 15; 73(3):447-53. PMID: 11884943.
    View in: PubMed
  128. Bitondo JM, Daggett WM, Torchiana DF, Akins CW, Hilgenberg AD, Vlahakes GJ, Madsen JC, MacGillivray TE, Agnihotri AK. Endoscopic versus open saphenous vein harvest: a comparison of postoperative wound complications. Ann Thorac Surg. 2002 Feb; 73(2):523-8. PMID: 11845868.
    View in: PubMed
  129. Benjamin LC, Allan JS, Madsen JC. Cytokines in immunity and allograft rejection. Crit Rev Immunol. 2002; 22(4):269-79. PMID: 12678428.
    View in: PubMed
  130. Bitondo JM, Daggett WM, Torchiana DF, Akins CW, Hilgenberg AD, Vlahakes GJ, Madsen JC, MacGillivray TE, Agnihotri AK. Endoscopic versus open saphenous vein harvest: A comparison of post-operative wound infections. Annals of Thoracic Surgery. 2002.
  131. Grünenfelder J, Akins CW, Hilgenberg AD, Vlahakes GJ, Torchiana DF, Madsen JC, MacGillivray TE. Long-term results and determinants of mortality after surgery for native and prosthetic valve endocarditis. J Heart Valve Dis. 2001 Nov; 10(6):694-702. PMID: 11767173.
    View in: PubMed
  132. Madsen JC. Tailoring tolerance to prevent chronic rejection. Transplantation. 2001 Oct 27; 72(8 Suppl):S10-2. PMID: 11888149.
    View in: PubMed
  133. Massicot-Fisher J, Noel P, Madsen JC. Recommendations of the National Heart, Lung and Blood Institute Heart and Lung Tolerance Working Group. Transplantation. 2001 Oct 27; 72(8):1467-70. PMID: 11685126.
    View in: PubMed
  134. Fuchimoto Y, Gleit ZL, Huang CA, Kitamura H, Schwarze ML, Menard MT, Mawulawde K, Madsen JC, Sachs DH. Skin-specific alloantigens in miniature swine. Transplantation. 2001 Jul 15; 72(1):122-6. PMID: 11468546.
    View in: PubMed
  135. Womer KL, Lee RS, Madsen JC, Sayegh MH. Tolerance and chronic rejection. Philos Trans R Soc Lond B Biol Sci. 2001 May 29; 356(1409):727-38. PMID: 11375075; PMCID: PMC1088459.
  136. Allan JS, Rose GA, Choo JK, Arn JS, Vesga L, Mawulawde K, Slisz JK, Allison K, Madsen JC. Morphometric analysis of miniature swine hearts as potential human xenografts. Xenotransplantation. 2001 May; 8(2):90-3. PMID: 11328578.
    View in: PubMed
  137. Lee RS, Yamada K, Houser SL, Womer KL, Maloney ME, Rose HS, Sayegh MH, Madsen JC. Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3276-81. PMID: 11248069; PMCID: PMC30644.
  138. Lee RS, Rusche JR, Maloney ME, Sachs DH, Sayegh MH, Madsen JC. CTLA4Ig-induced linked regulation of allogeneic T cell responses. J Immunol. 2001 Feb 01; 166(3):1572-82. PMID: 11160198.
    View in: PubMed
  139. Allan JS, Wain JC, Schwarze ML, Houser SL, Madsen JC, Sachs DH. Obliterative bronchiolitis develops in miniature swine transplanted across a minor histocompatibility barrier. Transplant Proc. 2001 Feb-Mar; 33(1-2):358-9. PMID: 11266860.
    View in: PubMed
  140. Lee RS, Yamada K, Houser SL, Womer KL, Maloney ME, Rose HS, Sayegh MH, Madsen JC. Indirect allorecognition promotes the development of cardiac allograft vasculopathy. Transplant Proc. 2001 Feb-Mar; 33(1-2):308-10. PMID: 11266832.
    View in: PubMed
  141. Lee RS, Rusche JR, Maloney ME, Sachs DH, Sayegh MH, Madsen JC. CTLA4Ig-induced linked regulation of allogeneic T cell responses. Transplant Proc. 2001 Feb-Mar; 33(1-2):88-9. PMID: 11266718.
    View in: PubMed
  142. Lee RS, Rusche JR, Cheatham LA, Yamada K, Houser SL, Maloney ME, Amoah HC, Mezrich JB, Sayegh MH, Madsen JC. CTLA4Ig and donor-specific transfusion prolongs cardiac allograft survival in the miniature swine. J Heart Lung Transplant. 2001 Feb; 20(2):150. PMID: 11250209.
    View in: PubMed
  143. Lee RS, Womer KL, Yamada K, Maloney ME, Houser SL, Sayegh MH, Madsen JC. The role of indirect recognition of donor MHC class II peptides in cardiac transplantation in miniature swine. J Heart Lung Transplant. 2001 Feb; 20(2):172. PMID: 11250273.
    View in: PubMed
  144. Mezrich JD, Yamada K, Lee RS, Mawulawde K, Houser SL, Schwarze ML, Maloney ME, Amoah HC, Pillsbury EP, Sachs DH, Madsen JC. Mechanisms of tolerance induction in the heart/kidney model in miniature swine. J Heart Lung Transplant. 2001 Feb; 20(2):172-173. PMID: 11250274.
    View in: PubMed
  145. Schwarze ML, Mezrich JD, Menard MT, Houser SL, Maloney ME, Pillsbury EP, Sachs DH, Madsen JC. The effects of mycophenolate mofetil on cardiac allograft survival and cardiac allograft vasculopathy in miniature swine. J Heart Lung Transplant. 2001 Feb; 20(2):160. PMID: 11250238.
    View in: PubMed
  146. Lee RS, KazuhikoY, Houser SL, Wormer KL, Maloney ME, Rose HS, Sayegh MH, Madsen JC. CTLA4Ig-induced linked regulation of allogenic T cell responses. Journal of Immunology. 2001; 166:1572-1582.
  147. Massicot-Fisher J, Noel P, Madsen JC. Recommendations of the NHLBI heart and lung tolerance working group. Transplantation. 2001; 72:1467-70.
  148. Mathes DW, Yaremchuk MJ, Isselbacher EM, Madsen JC. Successful in situ treatment of an infected ascending aortic graft. Ann Thorac Surg. 2000 Oct; 70(4):1410-2. PMID: 11081915.
    View in: PubMed
  149. Schwarze ML, Menard MT, Fuchimoto Y, Huang CA, Houser S, Mawulawde K, Allison KS, Sachs DH, Madsen JC. Mixed hematopoietic chimerism induces long-term tolerance to cardiac allografts in miniature swine. Ann Thorac Surg. 2000 Jul; 70(1):131-8; discussion 138-9. PMID: 10921697.
    View in: PubMed
  150. Yamada K, Mawulawde K, Menard MT, Shimizu A, Aretz HT, Choo JK, Allison KS, Slisz JK, Sachs DH, Madsen JC. Mechanisms of tolerance induction and prevention of cardiac allograft vasculopathy in miniature swine: the effect of augmentation of donor antigen load. J Thorac Cardiovasc Surg. 2000 Apr; 119(4 Pt 1):709-19. PMID: 10733759.
    View in: PubMed
  151. Lee RS, Yamada K, Womer KL, Pillsbury EP, Allison KS, Marolewski AE, Geng D, Thall AD, Arn JS, Sachs DH, Sayegh MH, Madsen JC. Blockade of CD28-B7, but not CD40-CD154, prevents costimulation of allogeneic porcine and xenogeneic human anti-porcine T cell responses. J Immunol. 2000 Mar 15; 164(6):3434-44. PMID: 10706740.
    View in: PubMed
  152. Schwarze ML, Menard MT, Fuchimoto Y, Huang CA, Houser S, Mawulawde K, Allison KS, Sachs DH, and Madsen JC. Mixed hematopoietic chimerism induces long term tolerance to cardiac allografts in miniature swine. The Annals of Thoracic Surgery. 2000; 70:131-139.
  153. Lee RS, Yamada K, Womer KL, Pillsbury EP, Allison KS, Marolewski AL, Geng D, Thall AD, Arn JS, Sachs DH, Sayegh MH, Madsen JC. Blockade of CD28-B7 but not CD40-CD154 prevents costimulation of allogeneic porcine and xenogeneic human anti-porcine T cell responses. The Journal of Immunology. 2000; 164:3434-3444.
  154. Pins MR, Ferrell MA, Madsen JC, Piubello Q, Dickersin GR, Fletcher CD. Epithelioid and spindle-celled leiomyosarcoma of the heart. Report of 2 cases and review of the literature. Arch Pathol Lab Med. 1999 Sep; 123(9):782-8. PMID: 10458824.
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  155. Yamada K, Choo JK, Allan JS, Erhorn AE, Menard MT, Mawulawde K, Slisz JK, Aretz HT, Shimizu A, Sachs DH, Madsen JC. The effect of thymectomy on tolerance induction and cardiac allograft vasculopathy in a miniature swine heart/kidney transplantation model. Transplantation. 1999 Aug 27; 68(4):485-91. PMID: 10480404.
    View in: PubMed
  156. Allan JS, Rose GA, Choo JK, Arn JS, Vesga L, Mawulawde K, Slisz JK, Allison K, Madsen JC. Morphometric analyses to predict appropriate donor size for swine-to-human cardiac xenotransplantation. Transplant Proc. 1999 Feb-Mar; 31(1-2):975-7. PMID: 10083434.
    View in: PubMed
  157. Yamada K, Menard MT, Mawulawde K, Slisz JK, Choo JK, Erhorn AE, Sachs DH, Madsen JC. The effects of heart/kidney versus double heart transplantation on tolerance induction and prevention of cardiac allograft vasculopathy. Transplant Proc. 1999 Feb-Mar; 31(1-2):108. PMID: 10083032.
    View in: PubMed
  158. Allan JS, Slisz JK, Vesga L, Arn JS, Yamada K, Sachs DH, Madsen JC. Enhanced efficacy of repeated anti-CD8 monoclonal antibody therapy by high-dose cyclosporine treatment. Transplant Proc. 1998 Dec; 30(8):4062-3. PMID: 9865295.
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  159. Lambrigts D, Menard MT, Alexandre GP, Franssen C, Meurisse M, Van Calster P, Coignoul F, Mawulawde K, Choo JK, Yamada K, Erhorn AE, Slisz JK, Chiotellis P, Aretz HT, Sachs DH, Madsen JC. Creation of the "thymoheart" allograft: implantation of autologous thymus into the heart prior to procurement. Transplantation. 1998 Sep 27; 66(6):810-4. PMID: 9771848.
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  160. Akins CW, Buckley MJ, Daggett WM, Hilgenberg AD, Vlahakes GJ, Torchiana DF, Madsen JC. Risk of reoperative valve replacement for failed mitral and aortic bioprostheses. Ann Thorac Surg. 1998 Jun; 65(6):1545-51; discussion 1551-2. PMID: 9647056.
    View in: PubMed
  161. Madsen JC, Daggett WM. Repair of postinfarction ventricular septal defects. Semin Thorac Cardiovasc Surg. 1998 Apr; 10(2):117-27. PMID: 9620459.
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  162. Madsen JC, Yamada K, Allan JS, Choo JK, Erhorn AE, Pins MR, Vesga L, Slisz JK, Sachs DH. Transplantation tolerance prevents cardiac allograft vasculopathy in major histocompatibility complex class I-disparate miniature swine. Transplantation. 1998 Feb 15; 65(3):304-13. PMID: 9484744.
    View in: PubMed
  163. Madsen JC, Yamada K, Allan JS, Choo JK, Erhorn AE, Pins MR, Vesga L, Slisz JK, Sachs DH. Transplantation tolerance prevents cardiac allograft vasculopathy in major histocompatibility class I-disparate miniature swine. Transplantation (Rapid Communication). 1998; 65:304-313.
  164. Akins CW, Buckley MJ, Daggett WM, Hilgenberg AD, Vlahakes GJ, Torchiana DF, Madsen JC. Risk of reoperative valve replacement for failed miral and aortic bioprostheses. Annals of Thoracic Surgery. 1998; 65:1545-52.
  165. Choo JK, Seebach JD, Nickeleit V, Shimizu A, Lei H, Sachs DH, Madsen JC. Species differences in the expression of major histocompatibility complex class II antigens on coronary artery endothelium: implications for cell-mediated xenoreactivity. Transplantation. 1997 Nov 15; 64(9):1315-22. PMID: 9371674.
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  166. Allan JS, Choo JK, Vesga L, Arn JS, Pins MR, Sachs DH, Madsen JC. Cardiac allograft vasculopathy is abrogated by anti-CD8 monoclonal antibody therapy. Ann Thorac Surg. 1997 Oct; 64(4):1019-25. PMID: 9354520.
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  167. Akins CW, Daggett WM, Vlahakes GJ, Hilgenberg AD, Torchiana DF, Madsen JC, Buckley MJ. Cardiac operations in patients 80 years old and older. Ann Thorac Surg. 1997 Sep; 64(3):606-14; discussion 614-5. PMID: 9307446.
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  168. Akins CW, Daggett WM, Vlahakes GJ, Hilgenberg AD, Torchiana DF, Madsen JC, Buckley MJ. Cardiac surgery in patients 80 years old and older. Annals of Thoracic Surgery. 1997; 64.
  169. Hilgenberg AD, Akins CW, Logan DL, Vlahakes GJ, Buckley MJ, Madsen JC, Torchiana DF. Composite aortic root replacement with direct coronary artery implantation. Ann Thorac Surg. 1996 Oct; 62(4):1090-5. PMID: 8823094.
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  170. Madsen JC, Sachs DH, Fallon JT, Weissman NJ. Cardiac allograft vasculopathy in partially inbred miniature swine. I. Time course, pathology, and dependence on immune mechanisms. J Thorac Cardiovasc Surg. 1996 Jun; 111(6):1230-9. PMID: 8642825.
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  171. Hajjar RJ, Rose GA, Madsen JC, Levine RA, DeSanctis RW. Extrapericardial cardiac tamponade after blunt chest trauma. Am Heart J. 1995 Sep; 130(3 Pt 1):620-1. PMID: 7661086.
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  172. Madsen JC, Mathisen DJ, Grillo HC. Cervical exenteration. Semin Thorac Cardiovasc Surg. 1992 Oct; 4(4):292-9. PMID: 1457569.
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  173. Pearson TC, Madsen JC, Larsen CP, Morris PJ, Wood KJ. Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody. Transplantation. 1992 Sep; 54(3):475-83. PMID: 1384183.
    View in: PubMed
  174. Pearson TC, Madsen JC, Wood KJ. Effect of anti-CD4 monoclonal antibody dosage when combined with donor antigen for the induction of transplantation tolerance. Transplant Proc. 1991 Feb; 23(1 Pt 1):565-6. PMID: 1990609.
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  175. Madsen JC. An immunogenetic analysis of immunological unresponsiveness using recipient cells transfected with donor MHC genes. 1991.
  176. Pearson TC, Madsen JC, Morris PJ, Wood KJ. The induction of transplantation tolerance using donor antigen and CD4 monoclonal antibody. Transplant Proc. 1990 Aug; 22(4):1955-6. PMID: 2389494.
    View in: PubMed
  177. Madsen JC, Wood KJ, Morris PJ. Effects of anti-L3T4 and anti-LYT2 monoclonal antibody therapy on cardiac allograft survival in presensitized recipients. Transplant Proc. 1989 Feb; 21(1 Pt 1):1022. PMID: 2495588.
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  178. Madsen JC, Wood KJ, Superina RA, Morris PJ. Induction of immunological unresponsiveness using recipient cells transfected with donor class I or class II MHC genes. Transplant Proc. 1989 Feb; 21(1 Pt 1):477. PMID: 2495614.
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  179. Madsen JC, Superina RA, Wood KJ, Morris PJ. Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes. Nature. 1988 Mar 10; 332(6160):161-4. PMID: 3279318.
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  180. Madsen JC, Peugh WN, Wood KJ, Morris PJ. The effect of anti-L3T4 monoclonal antibody treatment on first-set rejection of murine cardiac allografts. Transplantation. 1987 Dec; 44(6):849-52. PMID: 3321596.
    View in: PubMed
  181. Madsen JC, Wood KJ, Morris PJ. Effects of anti-L3T4 and anti-Lyt 2 monoclonal antibodies on murine cardiac allograft rejection. Transplant Proc. 1987 Oct; 19(5):3991-2. PMID: 3313979.
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  182. Madsen JC, Wood KJ, Morris PJ. The effect of anti-L3T4 and anti-Lyt 2 monoclonal antibodies on murine cardiac allograft rejection. Transplantation Proceedings. 1987; 19:3991-3992.
  183. Stromeyer CF, Kronauer RE, Madsen JC, Klein SA. Opponent-movement mechanisms in human vision. J Opt Soc Am A. 1984 Aug; 1(8):876-84. PMID: 6470838.
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  184. Stromeyer CF, Kronauer RE, Madsen JC. Adaptive processes controlling sensitivity of short-wave cone pathways to different spatial frequencies. Vision Res. 1984; 24(8):827-34. PMID: 6474838.
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  185. Stromeyer CF, Kronauer RE, Madsen JC, Klein S. Opponent movement mechanisms in human vision. Journal of the Optical Society of America. 1984; 81:876-884.
  186. Stromeyer CF, Kronauer RE, Madsen JC, Cohen MA. Spatial adaptation of short-wavelength pathways in humans. Science. 1980 Feb 01; 207(4430):555-7. PMID: 7352270.
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  187. Stromeyer CF, Kronauer RE, Madsen JC. Response saturation of short-wavelength cone pathways controlled by color-opponent mechanisms. Vision Res. 1979; 19(9):1025-40. PMID: 532116.
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  188. Stromeyer CF, Kronauer RE, Madsen JC. Apparent saturation of blue-sensitive cones occurs at a color-opponent stage. Science. 1978 Oct 13; 202(4364):217-9. PMID: 694527.
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  189. Stromeyer CF, Madsen JC, Klein S, Zeevi YY. Movement-selective mechanisms in human vision sensitive to high spatial frequencies. J Opt Soc Am. 1978 Jul; 68(7):1002-5. PMID: 712448.
    View in: PubMed
  190. Stromeyer CF, Madsen JC, Klein S. Direction of selective adaptation with very slow motion. Journal of the Optical Society of America. 1978; 69:1350-1354.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.