Harvard Catalyst Profiles

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Joren Christian Madsen, D.Phil., M.D.

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Mentoring
Available: 06/01/19, Expires: 05/30/24

Project: In the US alone, 22 people die each day waiting for a donor organ. Xenotransplantation with organs from CRISPR/Cas9 gene-edited swine will eliminate this crisis. We perform pig-to-nonhuman primate transplants with heart from pigs that have had 12-15 genes knocked out or in. Our goal is to identify the optimal "humanized" swine for use in patients dying of end-stage heart failure. Student Role: He/she will participate in the design, execution and analysis of each experiment. Furthermore, they will engage in large animal surgery and postoperative care.

Available: 06/01/19, Expires: 05/30/24

In the US alone, 22 people die each day waiting for a donor organ. Xenotransplantation with organs from CRISPR/Cas9 gene-edited swine will eliminate this crisis. We perform pig-to-nonhuman primate transplants with heart from pigs that have had up to 12 genes knocked out or in. Our goal is to identify the optimal "humanized" swine for use in patients dying of end-stage heart failure.

The student will participate in the design, execution and analysis of each experiment. Furthermore, they will engage in large animal surgery and postoperative care.

The Role of the Renal Tubular Epithelial Cell in Kidney-Induced Cardiac Allograft Tolerance
Summer, 06/11/12 - 08/17/12

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI148554 (MADSEN, JOREN C) Mar 17, 2021 - Feb 28, 2025
    NIH
    Achieving Clinically Relevant Tolerance in NHP Heart Allograft Recipients
    Role: Principal Investigator
  2. U01AI136816 (MADSEN, JOREN C) May 1, 2018 - Apr 30, 2023
    NIH
    Targeting Inflammation and Alloimmunity in Heart Transplant Recipients with Tocilizumab
    Role: Principal Investigator
  3. U01AI131470 (MADSEN, JOREN C) Jun 1, 2017 - May 31, 2022
    NIH
    Mixed chimerism induced tolerance in heart recipients requires donor kidney cotransplantation
    Role: Principal Investigator
  4. R34AI125058 (MADSEN, JOREN C) Aug 15, 2016 - Feb 28, 2018
    NIH
    Targeting Inflammation and Alloimmunity in Heart Transplant Recipients with Tocilizumab
    Role: Principal Investigator
  5. P01AI123086 (MADSEN, JOREN C) Aug 5, 2016 - Jul 31, 2021
    NIH
    Mechanisms of Kidney-Induced Cardiac Allograft Tolerance
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Cosimi AB, Ascher NL, Emond JC, Kaufman DB, Madsen JC, Miller J, Monaco AP, Montgomery RA, Newell KA, Sánchez-Fueyo A, Sarwal MM, Scandling JD, Strober S, Todo S, Weir MR, Sachs DH. The Importance of Bringing Transplantation Tolerance to the Clinic. Transplantation. 2021 May 01; 105(5):935-940. PMID: 33901128.
    Citations:    Fields:    
  2. van Leent MMT, Meerwaldt AE, Berchouchi A, Toner YC, Burnett ME, Klein ED, Verschuur AVD, Nauta SA, Munitz J, Prévot G, van Leeuwen EM, Ordikhani F, Mourits VP, Calcagno C, Robson PM, Soultanidis G, Reiner T, Joosten RRM, Friedrich H, Madsen JC, Kluza E, van der Meel R, Joosten LAB, Netea MG, Ochando J, Fayad ZA, Pérez-Medina C, Mulder WJM, Teunissen AJP. A modular approach toward producing nanotherapeutics targeting the innate immune system. Sci Adv. 2021 Mar; 7(10). PMID: 33674313.
    Citations:    Fields:    
  3. Habal MV, Miller AMI, Rao S, Lin S, Obradovic A, Khosravi-Maharlooei M, See SB, Roy P, Shihab R, Ho SH, Marboe CC, Naka Y, Takeda K, Restaino S, Han A, Mancini D, Givertz M, Madsen JC, Sykes M, Addonizio LJ, Farr MA, Zorn E. T cell repertoire analysis suggests a prominent bystander response in human cardiac allograft vasculopathy. Am J Transplant. 2021 04; 21(4):1465-1476. PMID: 33021057.
    Citations:    Fields:    
  4. Pierson RN, Fishman JA, Lewis GD, D'Alessandro DA, Connolly MR, Burdorf L, Madsen JC, Azimzadeh AM. Progress Toward Cardiac Xenotransplantation. Circulation. 2020 Oct 06; 142(14):1389-1398. PMID: 33017208.
    Citations:    Fields:    
  5. Yang C, Ge J, Rosales I, Yuan Q, Szuter E, Acheampong E, Russell PS, Madsen JC, Colvin RB, Alessandrini A. Kidney-induced systemic tolerance of heart allografts in mice. JCI Insight. 2020 09 17; 5(18). PMID: 32938831.
    Citations:    Fields:    
  6. Issa F, Strober S, Leventhal JR, Kawai T, Kaufman DB, Levitsky J, Sykes M, Mas V, Wood KJ, Bridges N, Welniak LA, Chandran S, Madsen JC, Nickerson P, Demetris AJ, Lakkis FG, Thomson AW. The Fourth International Workshop on Clinical Transplant Tolerance. Am J Transplant. 2021 01; 21(1):21-31. PMID: 32529725.
    Citations: 1     Fields:    
  7. Pierson RN, Burdorf L, Madsen JC, Lewis GD, D'Alessandro DA. Pig-to-human heart transplantation: Who goes first? Am J Transplant. 2020 10; 20(10):2669-2674. PMID: 32301262.
    Citations: 1     Fields:    
  8. O JM, Sommer W, White R, O'Shea T, Colvin RB, Madsen JC. RNA Expression Profiles of Heart Allografts in Tolerant Nonhuman Primates Resembles That Observed in Immunosuppressed Recipients. J Heart Lung Transplant. 2020 Apr; 39(4S):S360. PMID: 32465518.
    Citations:    
  9. O JM, Sommer W, Kurt P, Paster JT, Bean A, Dehnadi A, Hanekamp IM, Rosales I, Smith RN, Colvin RB, Benichou G, Allan JS, Kawai T, Madsen JC. Detrimental Effects of Donor Brain Death on Tolerance Induction May Be Eliminated by Delaying Mixed Chimerism in Non-Human Primates. J Heart Lung Transplant. 2020 Apr; 39(4S):S476. PMID: 32465848.
    Citations:    
  10. Ahrens K, O J, Sommer W, Morrissette J, Becerra D, Patel P, Costa T, Hanekamp IM, Benichou G, Madsen JC. IL-6 Receptor Blockade but Not IL-2 Treatment Contributes to Long Term NHP Cardiac Allograft Survival in Transient Mixed Chimeras. J Heart Lung Transplant. 2020 Apr; 39(4S):S70-S71. PMID: 32466014.
    Citations:    
  11. Morrissette JA, Pruner K, Lee S, Paster J, Sommer W, O J, Hanekamp I, Sage P, Benichou G, Madsen JC. Characterization of a Novel CD8+ B Cell Subset in Monkeys Tolerant of Heart Allografts. J Heart Lung Transplant. 2020 Apr; 39(4S):S89. PMID: 32466057.
    Citations:    
  12. Patel PM, Gonzalez-Nolasco BA, Morrissette JA, Prunevieille A, Kaitlan AJ, O JM, Becerra DC, Costa T, Benichou G, Madsen JC. Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates. J Heart Lung Transplant. 2020 Apr; 39(4S):S88. PMID: 32466055.
    Citations:    
  13. Benichou G, Wang M, Ahrens K, Madsen JC. Extracellular vesicles in allograft rejection and tolerance. Cell Immunol. 2020 03; 349:104063. PMID: 32087929.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  14. Yuan Q, Hong S, Perez-Ortiz A, Roth E, Chang DC, Madsen JC, Elias N. Effect of Recipient Hepatitis C Status on Outcomes of Deceased Donor Kidney Transplantation. J Am Coll Surg. 2020 06; 230(6):853-861.e3. PMID: 32035979.
    Citations:    Fields:    Translation:Humans
  15. Oh NA, O'Shea T, Ndishabandi DK, Yuan Q, Hong S, Gans J, Ge J, Gibney S, Chase C, Yang C, Rosales I, Shinoda K, Drew B, Kojima L, Russell PS, Madsen JC, Colvin RB, Alessandrini A. Plasmacytoid Dendritic Cell-driven Induction of Treg Is Strain Specific and Correlates With Spontaneous Acceptance of Kidney Allografts. Transplantation. 2020 01; 104(1):39-53. PMID: 31335760.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  16. Moore C, Gao B, Roskin KM, Vasilescu EM, Addonizio L, Givertz MM, Madsen JC, Zorn E. B cell clonal expansion within immune infiltrates in human cardiac allograft vasculopathy. Am J Transplant. 2020 05; 20(5):1431-1438. PMID: 31811777.
    Citations:    Fields:    
  17. Ochando J, Fayad ZA, Madsen JC, Netea MG, Mulder WJM. Trained immunity in organ transplantation. Am J Transplant. 2020 01; 20(1):10-18. PMID: 31561273.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  18. Loor G, Warnecke G, Villavicencio MA, Smith MA, Kukreja J, Ardehali A, Hartwig M, Daneshmand MA, Hertz MI, Huddleston S, Haverich A, Madsen JC, Van Raemdonck D. Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors (EXPAND): a single-arm, pivotal trial. Lancet Respir Med. 2019 11; 7(11):975-984. PMID: 31378427.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  19. Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 07 10; 11(500). PMID: 31292263.
    Citations: 4     Fields:    Translation:HumansAnimals
  20. Donadei C, Angeletti A, Cantarelli C, D'Agati VD, La Manna G, Fiaccadori E, Horwitz JK, Xiong H, Guglielmo C, Hartzell S, Madsen JC, Maggiore U, Heeger PS, Cravedi P. Erythropoietin inhibits SGK1-dependent TH17 induction and TH17-dependent kidney disease. JCI Insight. 2019 04 23; 5. PMID: 31013255.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  21. Fitch Z, Schmitz R, Kwun J, Hering B, Madsen J, Knechtle SJ. Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation. Transplant Rev (Orlando). 2019 07; 33(3):115-129. PMID: 31027947.
    Citations: 3     Fields:    Translation:Animals
  22. Hull TD, Benichou G, Madsen JC. Why some organ allografts are tolerated better than others: new insights for an old question. Curr Opin Organ Transplant. 2019 02; 24(1):49-57. PMID: 30516578.
    Citations: 2     Fields:    Translation:Humans
  23. Stehlik J, Armstrong B, Baran DA, Bridges ND, Chandraker A, Gordon R, De Marco T, Givertz MM, Heroux A, Iklé D, Hunt J, Kfoury AG, Madsen JC, Morrison Y, Feller E, Pinney S, Tripathi S, Heeger PS, Starling RC. Early immune biomarkers and intermediate-term outcomes after heart transplantation: Results of Clinical Trials in Organ Transplantation-18. Am J Transplant. 2019 05; 19(5):1518-1528. PMID: 30549425.
    Citations: 1     Fields:    Translation:HumansCells
  24. Robinson KA, Orent W, Madsen JC, Benichou G. Maintaining T cell tolerance of alloantigens: Lessons from animal studies. Am J Transplant. 2018 08; 18(8):1843-1856. PMID: 29939471.
    Citations: 1     Fields:    Translation:AnimalsCells
  25. Wang Z, Louras NJ, Lellouch AG, Pratts SG, Zhang H, Wang H, Huang CA, Cetrulo CL, Madsen JC, Sachs DH, Wang Z. Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates. Mol Oncol. 2018 08; 12(8):1374-1382. PMID: 29873181.
    Citations: 4     Fields:    Translation:AnimalsCells
  26. Warnecke G, Van Raemdonck D, Smith MA, Massard G, Kukreja J, Rea F, Loor G, De Robertis F, Nagendran J, Dhital KK, Moradiellos Díez FJ, Knosalla C, Bermudez CA, Tsui S, McCurry K, Wang IW, Deuse T, Lesèche G, Thomas P, Tudorache I, Kühn C, Avsar M, Wiegmann B, Sommer W, Neyrinck A, Schiavon M, Calabrese F, Santelmo N, Olland A, Falcoz PE, Simon AR, Varela A, Madsen JC, Hertz M, Haverich A, Ardehali A. Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study. Lancet Respir Med. 2018 05; 6(5):357-367. PMID: 29650408.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  27. Michel SG, Madariaga MLL, LaMuraglia GM, Villani V, Sekijima M, Farkash EA, Colvin RB, Sachs DH, Yamada K, Rosengard BR, Allan JS, Madsen JC. The effects of brain death and ischemia on tolerance induction are organ-specific. Am J Transplant. 2018 05; 18(5):1262-1269. PMID: 29377632.
    Citations: 1     Fields:    Translation:HumansAnimals
  28. Sasaki H, Oura T, Spitzer TR, Chen YB, Madsen JC, Allan J, Sachs DH, Cosimi AB, Kawai T. Preclinical and clinical studies for transplant tolerance via the mixed chimerism approach. Hum Immunol. 2018 May; 79(5):258-265. PMID: 29175110.
    Citations: 9     Fields:    Translation:HumansAnimals
  29. Madsen JC. Advances in the immunology of heart transplantation. J Heart Lung Transplant. 2017 12; 36(12):1299-1305. PMID: 29173391.
    Citations: 2     Fields:    Translation:Humans
  30. Chatterjee D, Moore C, Gao B, Clerkin KJ, See SB, Shaked D, Rogers K, Nunez S, Veras Y, Addonizio L, Givertz MM, Naka Y, Mancini D, Vasilescu R, Marboe C, Restaino S, Madsen JC, Zorn E. Prevalence of polyreactive innate clones among graft--infiltrating B cells in human cardiac allograft vasculopathy. J Heart Lung Transplant. 2018 03; 37(3):385-393. PMID: 29055600.
    Citations: 6     Fields:    Translation:HumansCells
  31. Wang Z, Zheng Q, Zhang H, Bronson RT, Madsen JC, Sachs DH, Huang CA, Wang Z. Ontak-like human IL-2 fusion toxin. J Immunol Methods. 2017 09; 448:51-58. PMID: 28551309.
    Citations: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  32. Zheng Q, Wang Z, Zhang H, Huang Q, Madsen JC, Sachs DH, Huang CA, Wang Z. Diphtheria toxin-based anti-human CD19 immunotoxin for targeting human CD19+ tumors. Mol Oncol. 2017 05; 11(5):584-594. PMID: 28306193.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  33. Purroy C, Fairchild RL, Tanaka T, Baldwin WM, Manrique J, Madsen JC, Colvin RB, Alessandrini A, Blazar BR, Fribourg M, Donadei C, Maggiore U, Heeger PS, Cravedi P. Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival. J Am Soc Nephrol. 2017 Aug; 28(8):2377-2392. PMID: 28302753.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  34. Nuñez S, Moore C, Gao B, Rogers K, Hidalgo Y, Del Nido PJ, Restaino S, Naka Y, Bhagat G, Madsen JC, Bono MR, Zorn E. The human thymus perivascular space is a functional niche for viral-specific plasma cells. Sci Immunol. 2016 Dec; 1(6). PMID: 28459117.
    Citations: 9     Fields:    
  35. Wang Z, Navarro-Alvarez N, Shah JA, Zhang H, Huang Q, Zheng Q, Madsen JC, Sachs DH, Huang CA, Wang Z. Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin. Vet Immunol Immunopathol. 2016 Dec; 182:150-158. PMID: 27863545.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  36. Hotta K, Aoyama A, Oura T, Yamada Y, Tonsho M, Huh KH, Kawai K, Schoenfeld D, Allan JS, Madsen JC, Benichou G, Smith RN, Colvin RB, Sachs DH, Cosimi AB, Kawai T. Induced regulatory T cells in allograft tolerance via transient mixed chimerism. JCI Insight. 2016 Jul 07; 1(10). PMID: 27446989.
    Citations: 16     Fields:    
  37. Sihag S, Haas MS, Kim KM, Guerrero JL, Beaudoin J, Alicot EM, Schuerpf F, Gottschall JD, Puro RJ, Madsen JC, Sachs DH, Newman W, Carroll MC, Allan JS. Natural IgM Blockade Limits Infarct Expansion and Left Ventricular Dysfunction in a Swine Myocardial Infarct Model. Circ Cardiovasc Interv. 2016 Jan; 9(1):e002547. PMID: 26671971.
    Citations:    Fields:    Translation:Animals
  38. Wang Z, Pratts SG, Zhang H, Spencer PJ, Yu R, Tonsho M, Shah JA, Tanabe T, Powell HR, Huang CA, Madsen JC, Sachs DH, Wang Z. Treg depletion in non-human primates using a novel diphtheria toxin-based anti-human CCR4 immunotoxin. Mol Oncol. 2016 Apr; 10(4):553-65. PMID: 26643572.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  39. Alexander SI, Madsen JC. Organ Transplant Tolerance for Children; in Sight for Some. J Pediatr. 2016 Jan; 168:232-235. PMID: 26581495.
    Citations:    Fields:    Translation:Humans
  40. La Muraglia GM, O'Neil MJ, Madariaga ML, Michel SG, Mordecai KS, Allan JS, Madsen JC, Hanekamp IM, Preffer FI. A novel approach to measuring cell-mediated lympholysis using quantitative flow and imaging cytometry. J Immunol Methods. 2015 Dec; 427:85-93. PMID: 26516062.
    Citations:    Fields:    Translation:AnimalsCells
  41. Madariaga ML, Spencer PJ, Michel SG, La Muraglia GM, O'Neil MJ, Mannon EC, Leblang C, Rosales IA, Colvin RB, Sachs DH, Allan JS, Madsen JC. Effects of Lung Cotransplantation on Cardiac Allograft Tolerance Across a Full Major Histocompatibility Complex Barrier in Miniature Swine. Am J Transplant. 2016 Mar; 16(3):979-86. PMID: 26469344.
    Citations: 2     Fields:    Translation:Animals
  42. Michel SG, La Muraglia GM, Madariaga ML, Titus JS, Selig MK, Farkash EA, Allan JS, Anderson LM, Madsen JC. Twelve-Hour Hypothermic Machine Perfusion for Donor Heart Preservation Leads to Improved Ultrastructural Characteristics Compared to Conventional Cold Storage. Ann Transplant. 2015 Aug 11; 20:461-8. PMID: 26259549.
    Citations: 7     Fields:    Translation:Animals
  43. Matthews KA, Tonsho M, Madsen JC. New-Onset Diabetes Mellitus After Transplantation in a Cynomolgus Macaque (Macaca fasicularis). Comp Med. 2015 Aug; 65(4):352-6. PMID: 26310466.
    Citations: 2     Fields:    Translation:Animals
  44. Madariaga MLL, Shanmugarajah K, Michel SG, Villani V, Muraglia GM, Torabi R, Leonard DA, Randolph MA, Colvin RB, Yamada K, Madsen JC, Cetrulo CL, Sachs DH. Immunomodulatory Strategies Directed Toward Tolerance of Vascularized Composite Allografts. Transplantation. 2015 Aug; 99(8):1590-1597. PMID: 25757218.
    Citations: 4     Fields:    Translation:AnimalsCells
  45. Madariaga ML, Kreisel D, Madsen JC. Organ-specific differences in achieving tolerance. Curr Opin Organ Transplant. 2015 Aug; 20(4):392-9. PMID: 26147678.
    Citations: 12     Fields:    Translation:HumansAnimals
  46. Yamada Y, Nadazdin O, Boskovic S, Lee S, Zorn E, Smith RN, Colvin RB, Madsen JC, Cosimi AB, Kawai T, Benichou G. Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced via Mixed Hematopoietic Chimerism in Monkeys. Am J Transplant. 2015 Dec; 15(12):3055-66. PMID: 26190648.
    Citations: 21     Fields:    Translation:Animals
  47. Madariaga ML, Michel SG, La Muraglia GM, Sihag S, Leonard DA, Farkash EA, Colvin RB, Cetrulo CL, Huang CA, Sachs DH, Madsen JC, Allan JS. Recipient-matching of Passenger Leukocytes Prolongs Survival of Donor Lung Allografts in Miniature Swine. Transplantation. 2015 Jul; 99(7):1372-8. PMID: 25757217.
    Citations: 1     Fields:    Translation:AnimalsCells
  48. Wang Z, Wei M, Zhang H, Chen H, Germana S, Huang CA, Madsen JC, Sachs DH, Wang Z. Diphtheria-toxin based anti-human CCR4 immunotoxin for targeting human CCR4(+) cells in vivo. Mol Oncol. 2015 Aug; 9(7):1458-70. PMID: 25958791.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  49. Tonsho M, Lee S, Aoyama A, Boskovic S, Nadazdin O, Capetta K, Smith RN, Colvin RB, Sachs DH, Cosimi AB, Kawai T, Madsen JC, Benichou G, Allan JS. Tolerance of Lung Allografts Achieved in Nonhuman Primates via Mixed Hematopoietic Chimerism. Am J Transplant. 2015 Aug; 15(8):2231-9. PMID: 25904524.
    Citations: 16     Fields:    Translation:Animals
  50. Madariaga ML, Michel SG, La Muraglia GM, Sekijima M, Villani V, Leonard DA, Powell HJ, Kurtz JM, Farkash EA, Colvin RB, Allan JS, Cetrulo CL, Huang CA, Sachs DH, Yamada K, Madsen JC. Kidney-induced cardiac allograft tolerance in miniature swine is dependent on MHC-matching of donor cardiac and renal parenchyma. Am J Transplant. 2015 Jun; 15(6):1580-90. PMID: 25824550.
    Citations: 5     Fields:    Translation:Animals
  51. Aoyama A, Tonsho M, Ng CY, Lee S, Millington T, Nadazdin O, Wain JC, Cosimi AB, Sachs DH, Smith RN, Colvin RB, Kawai T, Madsen JC, Benichou G, Allan JS. Long-term lung transplantation in nonhuman primates. Am J Transplant. 2015 May; 15(5):1415-20. PMID: 25772308.
    Citations: 10     Fields:    Translation:AnimalsCells
  52. Yamada Y, Ochiai T, Boskovic S, Nadazdin O, Oura T, Schoenfeld D, Cappetta K, Smith RN, Colvin RB, Madsen JC, Sachs DH, Benichou G, Cosimi AB, Kawai T. Use of CTLA4Ig for induction of mixed chimerism and renal allograft tolerance in nonhuman primates. Am J Transplant. 2014 Dec; 14(12):2704-12. PMID: 25394378.
    Citations: 21     Fields:    Translation:HumansAnimals
  53. Hirohashi T, Chase CM, DellaPelle P, Sebastian D, Farkesh E, Colvin RB, Russell PS, Alessandrini A, Madsen JC. Depletion of T regulatory cells promotes natural killer cell-mediated cardiac allograft vasculopathy. Transplantation. 2014 Oct 27; 98(8):828-34. PMID: 25321164.
    Citations: 2     Fields:    Translation:AnimalsCells
  54. Wei M, Marino J, Trowell A, Zhang H, Stromp Peraino J, Rajasekera PV, Madsen JC, Sachs DH, Huang CA, Benichou G, Wang Z. Diphtheria toxin-based recombinant murine IL-2 fusion toxin for depleting murine regulatory T cells in vivo. Protein Eng Des Sel. 2014 Sep; 27(9):289-95. PMID: 25147093.
    Citations: 6     Fields:    Translation:AnimalsCells
  55. Shinoda K, Akiyoshi T, Chase CM, Farkash EA, Ndishabandi DK, Raczek CM, Sebastian DP, Pelle PD, Russell PS, Madsen JC, Colvin RB, Alessandrini A. Depletion of foxp3(+) T cells abrogates tolerance of skin and heart allografts in murine mixed chimeras without the loss of mixed chimerism. Am J Transplant. 2014 Oct; 14(10):2263-2274. PMID: 25155089.
    Citations: 7     Fields:    Translation:AnimalsCells
  56. Michel SG, La Muraglia GM, Madariaga ML, Titus JS, Selig MK, Farkash EA, Allan JS, Anderson LM, Madsen JC. Preservation of donor hearts using hypothermic oxygenated perfusion. Ann Transplant. 2014 Aug 20; 19:409-16. PMID: 25139381.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  57. Kawai T, Leventhal J, Madsen JC, Strober S, Turka LA, Wood KJ. Tolerance: one transplant for life. Transplantation. 2014 Jul 27; 98(2):117-21. PMID: 24926829.
    Citations: 15     Fields:    Translation:Humans
  58. Tonsho M, Michel S, Ahmed Z, Alessandrini A, Madsen JC. Heart transplantation: challenges facing the field. Cold Spring Harb Perspect Med. 2014 May 01; 4(5). PMID: 24789875.
    Citations: 19     Fields:    Translation:HumansAnimals
  59. Peraino JS, Zhang H, Rajasekera PV, Wei M, Madsen JC, Sachs DH, Huang CA, Wang Z. Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25(+) cells. J Immunol Methods. 2014 Mar; 405:57-66. PMID: 24462799.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  60. Fitzsimons MG, Ichinose F, Vagefi PA, Markmann JF, Pierce ET, MacGillivray TE, Hertl M, Gauran C, Madsen JC, Baker J. Successful right ventricular mechanical support after combined heart-liver transplantation. J Cardiothorac Vasc Anesth. 2014 Dec; 28(6):1583-5. PMID: 24462515.
    Citations:    Fields:    Translation:Humans
  61. Gray Gilstrap L, Niehaus E, Malhotra R, Ton VK, Watts J, Seldin DC, Madsen JC, Semigran MJ. Predictors of survival to orthotopic heart transplant in patients with light chain amyloidosis. J Heart Lung Transplant. 2014 Feb; 33(2):149-56. PMID: 24200511.
    Citations: 14     Fields:    Translation:Humans
  62. Madariaga ML, Michel SG, Tasaki M, Villani V, La Muraglia GM, Sihag S, Gottschall J, Farkash EA, Shimizu A, Allan JS, Sachs DH, Yamada K, Madsen JC. Induction of cardiac allograft tolerance across a full MHC barrier in miniature swine by donor kidney cotransplantation. Am J Transplant. 2013 Oct; 13(10):2558-66. PMID: 24033991.
    Citations: 13     Fields:    Translation:HumansAnimals
  63. Akiyoshi T, Hirohashi T, Alessandrini A, Chase CM, Farkash EA, Neal Smith R, Madsen JC, Russell PS, Colvin RB. Role of complement and NK cells in antibody mediated rejection. Hum Immunol. 2012 Dec; 73(12):1226-32. PMID: 22850181.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  64. Aoyama A, Klarin D, Yamada Y, Boskovic S, Nadazdin O, Kawai K, Schoenfeld D, Madsen JC, Cosimi AB, Benichou G, Kawai T. Low-dose IL-2 for In vivo expansion of CD4+ and CD8+ regulatory T cells in nonhuman primates. Am J Transplant. 2012 Sep; 12(9):2532-7. PMID: 22682297.
    Citations: 10     Fields:    Translation:AnimalsCells
  65. Yamada Y, Aoyama A, Tocco G, Boskovic S, Nadazdin O, Alessandrini A, Madsen JC, Cosimi AB, Benichou G, Kawai T. Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates. J Immunol. 2012 Jun 15; 188(12):6063-70. PMID: 22586034.
    Citations: 11     Fields:    Translation:AnimalsCells
  66. Benichou G, Tonsho M, Tocco G, Nadazdin O, Madsen JC. Innate immunity and resistance to tolerogenesis in allotransplantation. Front Immunol. 2012; 3:73. PMID: 22566954.
    Citations: 9     Fields:    
  67. Millington T, Koulmanda M, Ng C, Boskovic S, Nadazdin OM, Benichou G, Zheng XX, Strom TB, Madsen JC. Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates. J Heart Lung Transplant. 2012 Apr; 31(4):427-35. PMID: 22366291.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  68. Liu W, Xiao X, Demirci G, Madsen J, Li XC. Innate NK cells and macrophages recognize and reject allogeneic nonself in vivo via different mechanisms. J Immunol. 2012 Mar 15; 188(6):2703-11. PMID: 22327074.
    Citations: 28     Fields:    Translation:AnimalsCells
  69. Meltzer AJ, Veillette GR, Aoyama A, Kim KM, Cochrane ME, Wain JC, Madsen JC, Sachs DH, Rosengard BR, Allan JS. Donor brain death inhibits tolerance induction in miniature swine recipients of fully MHC-disparate pulmonary allografts. Am J Transplant. 2012 May; 12(5):1290-5. PMID: 22300400.
    Citations: 4     Fields:    Translation:HumansAnimals
  70. Hirohashi T, Chase CM, Della Pelle P, Sebastian D, Alessandrini A, Madsen JC, Russell PS, Colvin RB. A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody. Am J Transplant. 2012 Feb; 12(2):313-21. PMID: 22070565.
    Citations: 72     Fields:    Translation:AnimalsCells
  71. Yamada Y, Boskovic S, Aoyama A, Murakami T, Putheti P, Smith RN, Ochiai T, Nadazdin O, Koyama I, Boenisch O, Najafian N, Bhasin MK, Colvin RB, Madsen JC, Strom TB, Sachs DH, Benichou G, Cosimi AB, Kawai T. Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates. Am J Transplant. 2012 Feb; 12(2):330-40. PMID: 22053723.
    Citations: 49     Fields:    Translation:AnimalsCells
  72. Nadazdin O, Boskovic S, Wee SL, Sogawa H, Koyama I, Colvin RB, Smith RN, Tocco G, O'Connor DH, Karl JA, Madsen JC, Sachs DH, Kawai T, Cosimi AB, Benichou G. Contributions of direct and indirect alloresponses to chronic rejection of kidney allografts in nonhuman primates. J Immunol. 2011 Nov 01; 187(9):4589-97. PMID: 21957140.
    Citations: 5     Fields:    Translation:AnimalsCells
  73. Song JJ, Kim SS, Liu Z, Madsen JC, Mathisen DJ, Vacanti JP, Ott HC. Enhanced in vivo function of bioartificial lungs in rats. Ann Thorac Surg. 2011 Sep; 92(3):998-1005; discussion 1005-6. PMID: 21871290.
    Citations: 63     Fields:    Translation:Animals
  74. Veillette GR, Sahara H, Meltzer AJ, Weiss MJ, Iwamoto Y, Kim KM, Rosengard BR, Allan JS, Houser SL, Sachs DH, Benichou G, Madsen JC. Autoimmune sensitization to cardiac myosin leads to acute rejection of cardiac allografts in miniature swine. Transplantation. 2011 Jun 15; 91(11):1187-91. PMID: 21512437.
    Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
  75. Nadazdin O, Boskovic S, Murakami T, Tocco G, Smith RN, Colvin RB, Sachs DH, Allan J, Madsen JC, Kawai T, Cosimi AB, Benichou G. Host alloreactive memory T cells influence tolerance to kidney allografts in nonhuman primates. Sci Transl Med. 2011 Jun 08; 3(86):86ra51. PMID: 21653831.
    Citations: 59     Fields:    Translation:AnimalsCells
  76. Russell PS, Chase CM, Madsen JC, Hirohashi T, Cornell LD, Sproule TJ, Colvin RB, Roopenian DC. Coronary artery disease from isolated non-H2-determined incompatibilities in transplanted mouse hearts. Transplantation. 2011 Apr 27; 91(8):847-52. PMID: 21378606.
    Citations: 10     Fields:    Translation:Animals
  77. Miyajima M, Chase CM, Alessandrini A, Farkash EA, Della Pelle P, Benichou G, Graham JA, Madsen JC, Russell PS, Colvin RB. Early acceptance of renal allografts in mice is dependent on foxp3(+) cells. Am J Pathol. 2011 Apr; 178(4):1635-45. PMID: 21435448.
    Citations: 42     Fields:    Translation:AnimalsCells
  78. Benichou G, Yamada Y, Aoyama A, Madsen JC. Natural killer cells in rejection and tolerance of solid organ allografts. Curr Opin Organ Transplant. 2011 Feb; 16(1):47-53. PMID: 21157342.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  79. Millington TM, Madsen JC. Innate immunity and cardiac allograft rejection. Kidney Int Suppl. 2010 Dec; (119):S18-21. PMID: 21116311.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  80. Dey BR, Chung SS, Spitzer TR, Zheng H, Macgillivray TE, Seldin DC, McAfee S, Ballen K, Attar E, Wang T, Shin J, Newton-Cheh C, Moore S, Sanchorawala V, Skinner M, Madsen JC, Semigran MJ. Cardiac transplantation followed by dose-intensive melphalan and autologous stem-cell transplantation for light chain amyloidosis and heart failure. Transplantation. 2010 Oct 27; 90(8):905-11. PMID: 20733534.
    Citations: 23     Fields:    Translation:Humans
  81. Evans RW, Applegate WH, Briscoe DM, Cohen DJ, Rorick CC, Murphy BT, Madsen JC. Cost-related immunosuppressive medication nonadherence among kidney transplant recipients. Clin J Am Soc Nephrol. 2010 Dec; 5(12):2323-8. PMID: 20847093.
    Citations: 25     Fields:    Translation:Humans
  82. Graham JA, Fray M, de Haseth S, Lee KM, Lian MM, Chase CM, Madsen JC, Markmann J, Benichou G, Colvin RB, Cosimi AB, Deng S, Kim J, Alessandrini A. Suppressive regulatory T cell activity is potentiated by glycogen synthase kinase 3{beta} inhibition. J Biol Chem. 2010 Oct 22; 285(43):32852-32859. PMID: 20729209.
    Citations: 26     Fields:    Translation:AnimalsCells
  83. Mehra MR, Crespo-Leiro MG, Dipchand A, Ensminger SM, Hiemann NE, Kobashigawa JA, Madsen J, Parameshwar J, Starling RC, Uber PA. International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy-2010. J Heart Lung Transplant. 2010 Jul; 29(7):717-27. PMID: 20620917.
    Citations: 117     Fields:    Translation:Humans
  84. Nadazdin O, Boskovic S, Murakami T, O'Connor DH, Wiseman RW, Karl JA, Tuscher JJ, Sachs DH, Madsen JC, Tocco G, Kawai T, Cosimi AB, Benichou G. Phenotype, distribution and alloreactive properties of memory T cells from cynomolgus monkeys. Am J Transplant. 2010 Jun; 10(6):1375-84. PMID: 20486921.
    Citations: 36     Fields:    Translation:AnimalsCells
  85. Nadazdin O, Abrahamian G, Boskovic S, Smith RN, Schoenfeld DA, Madsen JC, Colvin RB, Sachs DH, Cosimi AB, Kawai T. Stem cell mobilization and collection for induction of mixed chimerism and renal allograft tolerance in cynomolgus monkeys. J Surg Res. 2011 Jun 15; 168(2):294-300. PMID: 20605588.
    Citations: 4     Fields:    Translation:Animals
  86. Hirohashi T, Uehara S, Chase CM, DellaPelle P, Madsen JC, Russell PS, Colvin RB. Complement independent antibody-mediated endarteritis and transplant arteriopathy in mice. Am J Transplant. 2010 Mar; 10(3):510-7. PMID: 20055805.
    Citations: 39     Fields:    Translation:Animals
  87. Abbasi R, Abdou Y, Abu-Zayyad T, Adams J, Aguilar JA, Ahlers M, Andeen K, Auffenberg J, Bai X, Baker M, Barwick SW, Bay R, Bazo Alba JL, Beattie K, Beatty JJ, Bechet S, Becker JK, Becker KH, Benabderrahmane ML, Berdermann J, Berghaus P, Berley D, Bernardini E, Bertrand D, Besson DZ, Bissok M, Blaufuss E, Boersma DJ, Bohm C, Botner O, Bradley L, Braun J, Breder D, Carson M, Castermans T, Chirkin D, Christy B, Clem J, Cohen S, Cowen DF, D'Agostino MV, Danninger M, Day CT, De Clercq C, Demirörs L, Depaepe O, Descamps F, Desiati P, de Vries-Uiterweerd G, DeYoung T, Díaz-Vélez JC, Dreyer J, Dumm JP, Duvoort MR, Edwards WR, Ehrlich R, Eisch J, Ellsworth RW, Engdegård O, Euler S, Evenson PA, Fadiran O, Fazely AR, Feusels T, Filimonov K, Finley C, Foerster MM, Fox BD, Franckowiak A, Franke R, Gaisser TK, Gallagher J, Ganugapati R, Gerhardt L, Gladstone L, Goldschmidt A, Goodman JA, Gozzini R, Grant D, Griesel T, Gross A, Grullon S, Gunasingha RM, Gurtner M, Ha C, Hallgren A, Halzen F, Han K, Hanson K, Hasegawa Y, Helbing K, Herquet P, Hickford S, Hill GC, Hoffman KD, Homeier A, Hoshina K, Hubert D, Huelsnitz W, Hülss JP, Hulth PO, Hultqvist K, Hussain S, Imlay RL, Inaba M, Ishihara A, Jacobsen J, Japaridze GS, Johansson H, Joseph JM, Kampert KH, Kappes A, Karg T, Karle A, Kelley JL, Kemming N, Kenny P, Kiryluk J, Kislat F, Klein SR, Knops S, Kohnen G, Kolanoski H, Köpke L, Koskinen DJ, Kowalski M, Kowarik T, Krasberg M, Krings T, Kroll G, Kuehn K, Kuwabara T, Labare M, Lafebre S, Laihem K, Landsman H, Lauer R, Lehmann R, Lennarz D, Lundberg J, Lünemann J, Madsen J, Majumdar P, Maruyama R, Mase K, Matis HS, McParland CP, Meagher K, Merck M, Mészáros P, Meures T, Middell E, Milke N, Miyamoto H, Montaruli T, Morse R, Movit SM, Nahnhauer R, Nam JW, Niessen P, Nygren DR, Odrowski S, Olivas A, Olivo M, Ono M, Panknin S, Patton S, Paul L, Pérez de los Heros C, Petrovic J, Piegsa A, Pieloth D, Pohl AC, Porrata R, Potthoff N, Price PB, Prikockis M, Przybylski GT, Rawlins K, Redl P, Resconi E, Rhode W, Ribordy M, Rizzo A, Rodrigues JP, Roth P, Rothmaier F, Rott C, Roucelle C, Rutledge D, Ruzybayev B, Ryckbosch D, Sander HG, Sarkar S, Schatto K, Schlenstedt S, Schmidt T, Schneider D, Schukraft A, Schulz O, Schunck M, Seckel D, Semburg B, Seo SH, Sestayo Y, Seunarine S, Silvestri A, Slipak A, Spiczak GM, Spiering C, Stamatikos M, Stanev T, Stephens G, Stezelberger T, Stokstad RG, Stoufer MC, Stoyanov S, Strahler EA, Straszheim T, Sullivan GW, Swillens Q, Taboada I, Tamburro A, Tarasova O, Tepe A, Ter-Antonyan S, Terranova C, Tilav S, Toale PA, Tooker J, Tosi D, Turcan D, van Eijndhoven N, Vandenbroucke J, Van Overloop A, van Santen J, Voigt B, Walck C, Waldenmaier T, Wallraff M, Walter M, Wendt C, Westerhoff S, Whitehorn N, Wiebe K, Wiebusch CH, Wiedemann A, Wikström G, Williams DR, Wischnewski R, Wissing H, Woschnagg K, Xu C, Xu XW, Yodh G, Yoshida S. Extending the search for neutrino point sources with IceCube above the horizon. Phys Rev Lett. 2009 Nov 27; 103(22):221102. PMID: 20366087.
    Citations:    Fields:    
  88. Graham JA, Wilkinson RA, Hirohashi T, Chase CM, Colvin RB, Madsen JC, Fishman JA, Russell PS. Viral infection induces de novo lesions of coronary allograft vasculopathy through a natural killer cell-dependent pathway. Am J Transplant. 2009 Nov; 9(11):2479-84. PMID: 19843029.
    Citations: 13     Fields:    Translation:AnimalsCells
  89. Millington TM, Madsen JC. Innate immunity in heart transplantation. Curr Opin Organ Transplant. 2009 Oct; 14(5):571-6. PMID: 19542889.
    Citations: 5     Fields:    Translation:Humans
  90. White JK, Jagannath A, Titus J, Yoneyama R, Madsen J, Agnihotri AK. Funnel-tipped aortic cannula for reduction of atheroemboli. Ann Thorac Surg. 2009 Aug; 88(2):551-7. PMID: 19632411.
    Citations: 1     Fields:    Translation:Humans
  91. Stevens LM, Madsen JC, Isselbacher EM, Khairy P, MacGillivray TE, Hilgenberg AD, Agnihotri AK. Surgical management and long-term outcomes for acute ascending aortic dissection. J Thorac Cardiovasc Surg. 2009 Dec; 138(6):1349-57.e1. PMID: 19660400.
    Citations: 11     Fields:    Translation:Humans
  92. Abbasi R, Abdou Y, Ackermann M, Adams J, Ahlers M, Andeen K, Auffenberg J, Bai X, Baker M, Barwick SW, Bay R, Bazo Alba JL, Beattie K, Beatty JJ, Bechet S, Becker JK, Becker KH, Benabderrahmane ML, Berdermann J, Berghaus P, Berley D, Bernardini E, Bertrand D, Besson DZ, Bissok M, Blaufuss E, Boersma DJ, Bohm C, Bolmont J, Böser S, Botner O, Bradley L, Braun J, Breder D, Burgess T, Castermans T, Chirkin D, Christy B, Clem J, Cohen S, Cowen DF, D'Agostino MV, Danninger M, Day CT, De Clercq C, Demirörs L, Depaepe O, Descamps F, Desiati P, de Vries-Uiterweerd G, Deyoung T, Diaz-Velez JC, Dreyer J, Dumm JP, Duvoort MR, Edwards WR, Ehrlich R, Eisch J, Ellsworth RW, Engdegård O, Euler S, Evenson PA, Fadiran O, Fazely AR, Feusels T, Filimonov K, Finley C, Foerster MM, Fox BD, Franckowiak A, Franke R, Gaisser TK, Gallagher J, Ganugapati R, Gerhardt L, Gladstone L, Goldschmidt A, Goodman JA, Gozzini R, Grant D, Griesel T, Gross A, Grullon S, Gunasingha RM, Gurtner M, Ha C, Hallgren A, Halzen F, Han K, Hanson K, Hasegawa Y, Heise J, Helbing K, Herquet P, Hickford S, Hill GC, Hoffman KD, Hoshina K, Hubert D, Huelsnitz W, Hülss JP, Hulth PO, Hultqvist K, Hussain S, Imlay RL, Inaba M, Ishihara A, Jacobsen J, Japaridze GS, Johansson H, Joseph JM, Kampert KH, Kappes A, Karg T, Karle A, Kelley JL, Kenny P, Kiryluk J, Kislat F, Klein SR, Klepser S, Knops S, Kohnen G, Kolanoski H, Köpke L, Kowalski M, Kowarik T, Krasberg M, Kuehn K, Kuwabara T, Labare M, Lafebre S, Laihem K, Landsman H, Lauer R, Leich H, Lennarz D, Lucke A, Lundberg J, Lünemann J, Madsen J, Majumdar P, Maruyama R, Mase K, Matis HS, McParland CP, Meagher K, Merck M, Mészáros P, Middell E, Milke N, Miyamoto H, Mohr A, Montaruli T, Morse R, Movit SM, Münich K, Nahnhauer R, Nam JW, Niessen P, Nygren DR, Odrowski S, Olivas A, Olivo M, Ono M, Panknin S, Patton S, Pérez de Los Heros C, Petrovic J, Piegsa A, Pieloth D, Pohl AC, Porrata R, Potthoff N, Price PB, Prikockis M, Przybylski GT, Rawlins K, Redl P, Resconi E, Rhode W, Ribordy M, Rizzo A, Rodrigues JP, Roth P, Rothmaier F, Rott C, Roucelle C, Rutledge D, Ryckbosch D, Sander HG, Sarkar S, Satalecka K, Schlenstedt S, Schmidt T, Schneider D, Schukraft A, Schulz O, Schunck M, Seckel D, Semburg B, Seo SH, Sestayo Y, Seunarine S, Silvestri A, Slipak A, Spiczak GM, Spiering C, Stamatikos M, Stanev T, Stephens G, Stezelberger T, Stokstad RG, Stoufer MC, Stoyanov S, Strahler EA, Straszheim T, Sulanke KH, Sullivan GW, Swillens Q, Taboada I, Tarasova O, Tepe A, Ter-Antonyan S, Terranova C, Tilav S, Tluczykont M, Toale PA, Tosi D, Turcan D, van Eijndhoven N, Vandenbroucke J, Van Overloop A, Voigt B, Walck C, Waldenmaier T, Walter M, Wendt C, Westerhoff S, Whitehorn N, Wiebusch CH, Wiedemann A, Wikström G, Williams DR, Wischnewski R, Wissing H, Woschnagg K, Xu XW, Yodh G, Yoshida S. Limits on a muon flux from neutralino annihilations in the sun with the IceCube 22-string detector. Phys Rev Lett. 2009 May 22; 102(20):201302. PMID: 19519015.
    Citations: 1     Fields:    
  93. Weiss MJ, Guenther DA, Mezrich JD, Sahara H, Ng CY, Meltzer AJ, Sayre JK, Cochrane ME, Pujara AC, Houser SL, Sachs DH, Rosengard BR, Allan JS, Benichou G, Madsen JC. The indirect alloresponse impairs the induction but not maintenance of tolerance to MHC class I-disparate allografts. Am J Transplant. 2009 Jan; 9(1):105-13. PMID: 19145702.
    Citations: 4     Fields:    Translation:Animals
  94. Aoyama A, Ng CY, Millington TM, Boskovic S, Murakami T, Wain JC, Houser SL, Madsen JC, Kawai T, Allan JS. Comparison of lung and kidney allografts in induction of tolerance by a mixed-chimerism approach in cynomolgus monkeys. Transplant Proc. 2009 Jan-Feb; 41(1):429-30. PMID: 19249572.
    Citations: 18     Fields:    Translation:Animals
  95. Ng CY, Madsen JC, Rosengard BR, Allan JS. Immunosuppression for lung transplantation. Front Biosci (Landmark Ed). 2009 Jan 01; 14:1627-41. PMID: 19273152.
    Citations: 5     Fields:    Translation:Humans
  96. Meltzer AJ, Weiss MJ, Veillette GR, Sahara H, Ng CY, Cochrane ME, Houser SL, Sachs DH, Rosengard BR, Madsen JC, Wain JC, Allan JS. Repetitive gastric aspiration leads to augmented indirect allorecognition after lung transplantation in miniature swine. Transplantation. 2008 Dec 27; 86(12):1824-9. PMID: 19104429.
    Citations: 5     Fields:    Translation:Animals
  97. Traum AZ, Kawai T, Vacanti JP, Sachs DH, Cosimi AB, Madsen JC. The need for tolerance in pediatric organ transplantation. Pediatrics. 2008 Jun; 121(6):1258-60. PMID: 18519497.
    Citations: 3     Fields:    Translation:Humans
  98. Madsen JC. Sirolimus as primary immunosuppression is effective in attenuating progression of cardiac-allograft vasculopathy. Nat Clin Pract Cardiovasc Med. 2008 Jun; 5(6):300-1. PMID: 18461047.
    Citations:    Fields:    
  99. Cowan SW, Fiser SM, Albrecht M, Fifer M, Vlahakes GJ, Madsen JC. Management of coronary artery compression caused by recurrent aortic root abscess. J Card Surg. 2008 May-Jun; 23(3):195-7. PMID: 18435630.
    Citations: 4     Fields:    Translation:Humans
  100. Hoerbelt R, Benjamin CL, Shoji T, Houser SL, Muniappan A, Hasse RS, Ledgerwood LG, Allan JS, Sachs DH, Madsen JC. The effects of tolerance on allograft damage caused by the innate immune system. Transplantation. 2008 Feb 15; 85(3):314-22. PMID: 18301326.
    Citations: 1     Fields:    Translation:Animals
  101. Weiss MJ, Madsen JC, Rosengard BR, Allan JS. Mechanisms of chronic rejection in cardiothoracic transplantation. Front Biosci. 2008 Jan 01; 13:2980-8. PMID: 17981771.
    Citations: 12     Fields:    Translation:HumansCells
  102. Shoji T, Sahara H, Muniappan A, Guenther DA, Wain JC, Houser SL, Bravard MA, Pujara AC, Hasse RS, Sachs DH, Madsen JC, Allan JS. Operational tolerance to class I disparate lungs can be induced despite pretransplant immunization with class I allopeptides. Transplantation. 2007 Dec 15; 84(11):1467-73. PMID: 18091523.
    Citations:    Fields:    Translation:Animals
  103. Kitchens WH, Chase CM, Uehara S, Cornell LD, Colvin RB, Russell PS, Madsen JC. Macrophage depletion suppresses cardiac allograft vasculopathy in mice. Am J Transplant. 2007 Dec; 7(12):2675-82. PMID: 17924996.
    Citations: 50     Fields:    Translation:AnimalsCells
  104. Dormond O, Madsen JC, Briscoe DM. The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells. J Biol Chem. 2007 Aug 10; 282(32):23679-86. PMID: 17553806.
    Citations: 64     Fields:    Translation:HumansCells
  105. Benichou G, Kant CD, Madsen J, Tocco G. Modulation of alloreactivity to MHC-derived peptides and transplantation tolerance. Front Biosci. 2007 May 01; 12:4239-47. PMID: 17485370.
    Citations:    Fields:    Translation:Humans
  106. Houser S, Muniappan A, Allan J, Sachs D, Madsen J. Cardiac allograft vasculopathy: real or a normal morphologic variant? J Heart Lung Transplant. 2007 Feb; 26(2):167-73. PMID: 17258151.
    Citations: 3     Fields:    Translation:HumansAnimals
  107. Uehara S, Chase CM, Cornell LD, Madsen JC, Russell PS, Colvin RB. Chronic cardiac transplant arteriopathy in mice: relationship of alloantibody, C4d deposition and neointimal fibrosis. Am J Transplant. 2007 Jan; 7(1):57-65. PMID: 17227558.
    Citations: 30     Fields:    Translation:AnimalsCells
  108. Hoerbelt R, Benjamin LC, Shoji T, Johnston DR, Muniappan A, Guenther DA, Allan JS, Houser SL, Madsen JC. Effects of tolerance induction on the actions of interferon-gamma on porcine cardiac allografts. Transplant Proc. 2006 Dec; 38(10):3196-8. PMID: 17175220.
    Citations: 1     Fields:    Translation:Animals
  109. Uehara S, Chase CM, Colvin RB, Madsen JC, Russell PS. T-cell depletion eliminates the development of cardiac allograft vasculopathy in mice rendered tolerant by the induction of mixed chimerism. Transplant Proc. 2006 Dec; 38(10):3169-71. PMID: 17175214.
    Citations: 6     Fields:    Translation:AnimalsCells
  110. Shoji T, Sahara H, Muniappan A, Guenther DA, Houser SL, Pujara AC, Bravard MA, Wain JC, Sachs DH, Madsen JC, Allan JS. An MHC class II disparity raises the threshold for tolerance induction in pulmonary allografts in miniature swine. Transplant Proc. 2006 Dec; 38(10):3268-70. PMID: 17175245.
    Citations: 5     Fields:    Translation:Animals
  111. Sahara H, Shoji T, Ng CY, Weiss MJ, Muniappan A, Guenther DA, Houser SL, Pujara AC, Sayre JK, Wain JC, Sachs DH, Madsen JC, Allan JS. The role of indirect recognition of MHC class I and II allopeptides in a fully mismatched miniature swine model of lung transplantation. Transplant Proc. 2006 Dec; 38(10):3256-8. PMID: 17175241.
    Citations: 2     Fields:    Translation:Animals
  112. Sahara H, Weiss MJ, Ng CY, Houser SL, Pujara AC, Sayre JK, Wain JC, Sachs DH, Madsen JC, Allan JS. Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine. Transplant Proc. 2006 Dec; 38(10):3253-5. PMID: 17175240.
    Citations: 1     Fields:    Translation:Animals
  113. Achterberg A, Ackermann M, Adams J, Ahrens J, Andeen K, Atlee DW, Bahcall JN, Bai X, Baret B, Bartelt M, Barwick SW, Bay R, Beattie K, Becka T, Becker JK, Becker KH, Berghaus P, Berley D, Bernardini E, Bertrand D, Besson DZ, Blaufuss E, Boersma DJ, Bohm C, Bolmont J, Böser S, Botner O, Bouchta A, Braun J, Burgess C, Burgess T, Castermans T, Chirkin D, Christy B, Clem J, Cowen DF, D'Agostino MV, Davour A, Day CT, De Clercq C, Demirörs L, Descamps F, Desiati P, Deyoung T, Diaz-Velez JC, Dreyer J, Dumm JP, Duvoort MR, Edwards WR, Ehrlich R, Eisch J, Ellsworth RW, Evenson PA, Fadiran O, Fazely AR, Feser T, Filimonov K, Fox BD, Gaisser TK, Gallagher J, Ganugapati R, Geenen H, Gerhardt L, Goldschmidt A, Goodman JA, Gozzini R, Grullon S, Gross A, Gunasingha RM, Gurtner M, Hallgren A, Halzen F, Han K, Hanson K, Hardtke D, Hardtke R, Harenberg T, Hart JE, Hauschildt T, Hays D, Heise J, Helbing K, Hellwig M, Herquet P, Hill GC, Hodges J, Hoffman KD, Hommez B, Hoshina K, Hubert D, Hughey B, Hulth PO, Hultqvist K, Hundertmark S, Hülss JP, Ishihara A, Jacobsen J, Japaridze GS, Jones A, Joseph JM, Kampert KH, Karle A, Kawai H, Kelley JL, Kestel M, Kitamura N, Klein SR, Klepser S, Kohnen G, Kolanoski H, Köpke L, Krasberg M, Kuehn K, Landsman H, Leich H, Liubarsky I, Lundberg J, Madsen J, Mase K, Matis HS, McCauley T, McParland CP, Meli A, Messarius T, Mészáros P, Miyamoto H, Mokhtarani A, Montaruli T, Morey A, Morse R, Movit SM, Münich K, Nahnhauer R, Nam JW, Niessen P, Nygren DR, Ogelman H, Olbrechts P, Olivas A, Patton S, Peña-Garay C, Pérez de Los Heros C, Piegsa A, Pieloth D, Pohl AC, Porrata R, Pretz J, Price PB, Przybylski GT, Rawlins K, Razzaque S, Refflinghaus F, Resconi E, Rhode W, Ribordy M, Rizzo A, Robbins S, Roth P, Rott C, Rutledge D, Ryckbosch D, Sander HG, Sarkar S, Schlenstedt S, Schmidt T, Schneider D, Seckel D, Seo SH, Seunarine S, Silvestri A, Smith AJ, Solarz M, Song C, Sopher JE, Spiczak GM, Spiering C, Stamatikos M, Stanev T, Steffen P, Stezelberger T, Stokstad RG, Stoufer MC, Stoyanov S, Strahler EA, Straszheim T, Sulanke KH, Sullivan GW, Sumner TJ, Taboada I, Tarasova O, Tepe A, Thollander L, Tilav S, Toale PA, Turcan D, van Eijndhoven N, Vandenbroucke J, Van Overloop A, Voigt B, Wagner W, Walck C, Waldmann H, Walter M, Wang YR, Wendt C, Wiebusch CH, Wikström G, Williams DR, Wischnewski R, Wissing H, Woschnagg K, Xu XW, Yodh G, Yoshida S, Zornoza JD. Limits on the high-energy gamma and neutrino fluxes from the SGR 1806-20 giant flare of 27 December 2004 with the AMANDA-II detector. Phys Rev Lett. 2006 Dec 01; 97(22):221101. PMID: 17155787.
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  114. Weiss MJ, Ng CY, Madsen JC. Tolerance, xenotransplantation: future therapies. Surg Clin North Am. 2006 Oct; 86(5):1277-96, viii. PMID: 16962414.
    Citations: 2     Fields:    Translation:HumansAnimals
  115. Dormond O, Madsen JC. Invited commentary. Ann Thorac Surg. 2006 May; 81(5):1736-7. PMID: 16631664.
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  116. Kitchens WH, Uehara S, Chase CM, Colvin RB, Russell PS, Madsen JC. The changing role of natural killer cells in solid organ rejection and tolerance. Transplantation. 2006 Mar 27; 81(6):811-7. PMID: 16570001.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  117. Akins CW, Hilgenberg AD, Vlahakes GJ, Madsen JC, MacGillivray TE, LaMuraglia GM, Cambria RP. Late results of combined carotid and coronary surgery using actual versus actuarial methodology. Ann Thorac Surg. 2005 Dec; 80(6):2091-7. PMID: 16305851.
    Citations: 4     Fields:    Translation:Humans
  118. Hoerbelt R, Johnston DR, Shoji T, Houser SL, Hasse RS, Ledgerwood LG, Iribarne A, Allan JS, Sayegh MH, Sachs DH, Madsen JC. Combination treatment with donor-specific transfusions and cyclosporine a induces long-term survival of cardiac allografts in miniature Swine. Transplantation. 2005 Nov 15; 80(9):1275-82. PMID: 16314796.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  119. Schwarze ML, Houser SL, Muniappan A, Allan JS, Menard MT, McMorrow I, Maloney ME, Madsen JC. Effects of mycophenolate mofetil on cardiac allograft survival and cardiac allograft vasculopathy in miniature swine. Ann Thorac Surg. 2005 Nov; 80(5):1787-93. PMID: 16242456.
    Citations: 2     Fields:    Translation:Animals
  120. Akins CW, Bitondo JM, Hilgenberg AD, Vlahakes GJ, Madsen JC, MacGillivray TE. Early and late results of the surgical correction of cardiac prosthetic paravalvular leaks. J Heart Valve Dis. 2005 Nov; 14(6):792-9; discussion 799-800. PMID: 16359061.
    Citations: 17     Fields:    Translation:Humans
  121. Uehara S, Chase CM, Kitchens WH, Rose HS, Colvin RB, Russell PS, Madsen JC. NK cells can trigger allograft vasculopathy: the role of hybrid resistance in solid organ allografts. J Immunol. 2005 Sep 01; 175(5):3424-30. PMID: 16116237.
    Citations: 53     Fields:    Translation:AnimalsCells
  122. Smith RN, Brousaides N, Grazette L, Saidman S, Semigran M, Disalvo T, Madsen J, Dec GW, Perez-Atayde AR, Collins AB. C4d deposition in cardiac allografts correlates with alloantibody. J Heart Lung Transplant. 2005 Sep; 24(9):1202-10. PMID: 16143234.
    Citations: 12     Fields:    Translation:Humans
  123. Johnston DR, Muniappan A, Hoerbelt R, Guenther DA, Shoji T, Houser SL, Sachs DH, Madsen JC. Heart and en-bloc thymus transplantation in miniature swine. J Thorac Cardiovasc Surg. 2005 Aug; 130(2):554-9. PMID: 16077427.
    Citations: 4     Fields:    Translation:Animals
  124. Wong DR, Agnihotri AK, Hung JW, Vlahakes GJ, Akins CW, Hilgenberg AD, Madsen JC, MacGillivray TE, Picard MH, Torchiana DF. Long-term survival after surgical revascularization for moderate ischemic mitral regurgitation. Ann Thorac Surg. 2005 Aug; 80(2):570-7. PMID: 16039207.
    Citations: 20     Fields:    Translation:Humans
  125. Shoji T, Wain JC, Houser SL, Benjamin LC, Johnston DR, Hoerbelt R, Hasse RS, Lee RS, Muniappan A, Guenther DA, Bravard MA, Ledgerwood LG, Sachs DH, Sayegh MH, Madsen JC, Allan JS. Indirect recognition of MHC class I allopeptides accelerates lung allograft rejection in miniature swine. Am J Transplant. 2005 Jul; 5(7):1626-34. PMID: 15943620.
    Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  126. Mezrich JD, Benjamin LC, Sachs JA, Houser SL, Vagefi PA, Sachs DH, Madsen JC, Yamada K. Role of the thymus and kidney graft in the maintenance of tolerance to heart grafts in miniature swine. Transplantation. 2005 Jun 27; 79(12):1663-73. PMID: 15973167.
    Citations: 6     Fields:    Translation:Animals
  127. Guenther DA, Madsen JC. Advances in strategies for inducing central tolerance in organ allograft recipients. Pediatr Transplant. 2005 Jun; 9(3):277-81. PMID: 15910381.
    Citations: 3     Fields:    Translation:HumansAnimals
  128. Shoji T, Muniappan A, Guenther DA, Wain JC, Houser SL, Hoerbelt R, Benjamin LC, Hasse RS, Bravard MA, Sachs DH, Madsen JC, Allan JS. Long-term acceptance of porcine pulmonary allografts without chronic rejection. Transplant Proc. 2005 Jan-Feb; 37(1):72-4. PMID: 15808551.
    Citations: 6     Fields:    Translation:Animals
  129. Schroeder C, Allan JS, Nguyen BN, Wu G, Zhang T, Azimzadeh AM, Madsen JC, Schuurman HJ, Sachs DH, Pierson RN. Hyperacute rejection is attenuated in GalT knockout swine lungs perfused ex vivo with human blood. Transplant Proc. 2005 Jan-Feb; 37(1):512-3. PMID: 15808693.
    Citations: 5     Fields:    Translation:HumansAnimals
  130. Uehara S, Chase CM, Colvin RB, Russell PS, Madsen JC. Further evidence that NK cells may contribute to the development of cardiac allograft vasculopathy. Transplant Proc. 2005 Jan-Feb; 37(1):70-1. PMID: 15808550.
    Citations: 4     Fields:    Translation:AnimalsCells