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profileWilliam J Savage, Ph.D., M.D.

TitleAssistant Professor of Pathology
InstitutionBrigham and Women's Hospital
DepartmentPathology
AddressBrigham and Womens Hospital
Amory-2 (Rm 260)
75 Francis St
Boston MA 02115
Phone443/691-6014
Fax617/277-9013
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R21HL107828     (SAVAGE, WILLIAM)Jan 1, 2012 - Mar 30, 2014
NIH/NHLBI
Mechanisms of Allergic Transfusion Reactions
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Savage WJ. It's time to step up to the plate and BAT. Transfusion. 2017 Sep; 57(9):2061-2062. PMID: 28868741.
    View in: PubMed
  2. Savage WJ, Burns JR, Fiering J. Safety of acoustic separation in plastic devices for extracorporeal blood processing. Transfusion. 2017 Jul; 57(7):1818-1826. PMID: 28555930.
    View in: PubMed
  3. Lee DD, Muskaj I, Savage W. Platelet proteins cause basophil histamine release through an immunoglobulin-dependent mechanism. Transfusion. 2017 Jul; 57(7):1709-1716. PMID: 28470742.
    View in: PubMed
  4. Cure P, Bembea M, Chou S, Doctor A, Eder A, Hendrickson J, Josephson CD, Mast AE, Savage W, Sola-Visner M, Spinella P, Stanworth S, Steiner M, Mondoro T, Zou S, Levy C, Waclawiw M, El Kassar N, Glynn S, Luban NLC. 2016 proceedings of the National Heart, Lung, and Blood Institute's scientific priorities in pediatric transfusion medicine. Transfusion. 2017 Jun; 57(6):1568-1581. PMID: 28369923.
    View in: PubMed
  5. Woolley AE, Montgomery MW, Savage WJ, Achebe MO, Dunford K, Villeda S, Maguire JH, Marty FM. Post-Babesiosis Warm Autoimmune Hemolytic Anemia. N Engl J Med. 2017 03 09; 376(10):939-946. PMID: 28273010.
    View in: PubMed
  6. Savage WJ. Transfusion Reactions. Hematol Oncol Clin North Am. 2016 Jun; 30(3):619-34. PMID: 27113000.
    View in: PubMed
  7. Simmons DP, Savage WJ. Hemolysis from ABO Incompatibility. Hematol Oncol Clin North Am. 2015 Jun; 29(3):429-43. PMID: 26043383.
    View in: PubMed
  8. Savage W. The unique challenges of hemovigilance for pediatric patients. Transfusion. 2015 Mar; 55(3):466-7. PMID: 25759127.
    View in: PubMed
  9. Savage WJ, Buchanan GR, Yawn BP, Afenyi-Annan AN, Ballas SK, Goldsmith JC, Hassell KL, James AH, John-Sowah J, Jordan L, Lottenberg R, Murad MH, Ortiz E, Tanabe PJ, Ware RE, Lanzkron SM. Evidence gaps in the management of sickle cell disease: A summary of needed research. Am J Hematol. 2015 Apr; 90(4):273-5. PMID: 25639238.
    View in: PubMed
  10. Siegal DM, Savage WJ. Plasma versus prothrombin complex concentrate for warfarin-associated major bleeding: a systematic review. Hematology Am Soc Hematol Educ Program. 2015; 2015:448-53. PMID: 26637757.
    View in: PubMed
  11. Savage W. Implementing a blood utilization program to optimize transfusion practice. Hematology Am Soc Hematol Educ Program. 2015; 2015:444-7. PMID: 26637756.
    View in: PubMed
  12. Kacker S, Ness PM, Shirey RS, Savage WJ, King KE, Tobian AA. The future of red blood cell alloimmunization risk reduction. Transfusion. 2015 Jan; 55(1):222-4. PMID: 25582240; PMCID: PMC4739819.
  13. Savage WJ, Tobian AA, Savage JH, Hamilton RG, Borge PD, Kaufman RM, Ness PM. Transfusion and component characteristics are not associated with allergic transfusion reactions to apheresis platelets. Transfusion. 2015 Feb; 55(2):296-300. PMID: 25209730; PMCID: PMC4331230.
  14. Yawn BP, Buchanan GR, Afenyi-Annan AN, Ballas SK, Hassell KL, James AH, Jordan L, Lanzkron SM, Lottenberg R, Savage WJ, Tanabe PJ, Ware RE, Murad MH, Goldsmith JC, Ortiz E, Fulwood R, Horton A, John-Sowah J. Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. JAMA. 2014 Sep 10; 312(10):1033-48. PMID: 25203083.
    View in: PubMed
  15. Savage WJ, Kaufman RM. Transfusion medicine illustrated. An allergic transfusion reaction with angioedema. Transfusion. 2014 Aug; 54(8):1916. PMID: 25130332.
    View in: PubMed
  16. Brown CH, Grega M, Selnes OA, McKhann GM, Shah AS, LaFlam A, Savage WJ, Frank SM, Hogue CW, Gottesman RF. Length of red cell unit storage and risk for delirium after cardiac surgery. Anesth Analg. 2014 Aug; 119(2):242-50. PMID: 24859077; PMCID: PMC4107069.
  17. Kaufman RM, Savage WJ. Staphylococcus aureus sepsis from one cocomponent of a "triple" apheresis platelet donation. Transfusion. 2014 Jul; 54(7):1704. PMID: 25041148.
    View in: PubMed
  18. Brown CH, Savage WJ, Masear CG, Walston JD, Tian J, Colantuoni E, Hogue CW, Frank SM. Odds of transfusion for older adults compared to younger adults undergoing surgery. Anesth Analg. 2014 Jun; 118(6):1168-78. PMID: 24413550.
    View in: PubMed
  19. Savage WJ, Hamilton RG, Tobian AA, Milne GL, Kaufman RM, Savage JH, Borge PD, Ness PM. Defining risk factors and presentations of allergic reactions to platelet transfusion. J Allergy Clin Immunol. 2014 Jun; 133(6):1772-5.e9. PMID: 24794681; PMCID: PMC4040306.
  20. Kacker S, Ness PM, Savage WJ, Frick KD, Shirey RS, King KE, Tobian AA. Economic evaluation of a hypothetical screening assay for alloimmunization risk among transfused patients with sickle cell disease. Transfusion. 2014 Aug; 54(8):2034-44. PMID: 24571485; PMCID: PMC4138280.
  21. Savage W, Tobian AA, Ness PM, Kaufman RM. Desensitization in allergic transfusion reactions: evidence from the Trial to Reduce Alloimmunization to Platelets. Transfusion. 2014 Feb; 54(2):496-8. PMID: 24517134; PMCID: PMC3929224.
  22. Grant MC, Whitman GJ, Savage WJ, Ness PM, Frank SM. Clinical predictors of postoperative hemoglobin drift. Transfusion. 2014 Jun; 54(6):1460-8. PMID: 24236570.
    View in: PubMed
  23. Savage WJ, Reddoch S, Wolfe J, Casella JF. Partial manual exchange reduces iron accumulation during chronic red cell transfusions for sickle cell disease. J Pediatr Hematol Oncol. 2013 Aug; 35(6):434-6. PMID: 23887022; PMCID: PMC3753792.
  24. Frank SM, Rothschild JA, Masear CG, Rivers RJ, Merritt WT, Savage WJ, Ness PM. Optimizing preoperative blood ordering with data acquired from an anesthesia information management system. Anesthesiology. 2013 Jun; 118(6):1286-97. PMID: 23695091.
    View in: PubMed
  25. Kacker S, Ness PM, Savage WJ, Frick KD, Shirey RS, King KE, Tobian AA. Cost-effectiveness of prospective red blood cell antigen matching to prevent alloimmunization among sickle cell patients. Transfusion. 2014 Jan; 54(1):86-97. PMID: 23692415; PMCID: PMC3758770.
  26. Faulcon LM, Fu Z, Dulloor P, Barron-Casella E, Savage W, Jennings JM, Van Eyk JE, Debaun M, Casella JF, Everett A. Thrombospondin-1 and L-selectin are associated with silent cerebral infarct in children with sickle cell anaemia. Br J Haematol. 2013 Aug; 162(3):421-4. PMID: 23672305; PMCID: PMC4391368.
  27. Frank SM, Resar LM, Rothschild JA, Dackiw EA, Savage WJ, Ness PM. A novel method of data analysis for utilization of red blood cell transfusion. Transfusion. 2013 Dec; 53(12):3052-9. PMID: 23621848.
    View in: PubMed
  28. Kacker S, Ness PM, Savage WJ, Frick KD, McCullough J, King KE, Tobian AA. The cost-effectiveness of platelet additive solution to prevent allergic transfusion reactions. Transfusion. 2013 Nov; 53(11):2609-18. PMID: 23363552; PMCID: PMC3650119.
  29. Wolfe JL, Anders RA, Reddoch S, Schwarz KB, Savage WJ. Longitudinal changes in liver fibrosis in children with sickle cell disease undergoing chronic transfusion therapy. Acta Gastroenterol Belg. 2012 Dec; 75(4):419-24. PMID: 23402085.
    View in: PubMed
  30. Holdhoff M, Savage WJ, Dulloor P, Grossman SA, Everett A. Preliminary results of a biomarker discovery project for treatment-related brain injury (TRBI) in malignant glioma. J Clin Oncol. 2012 Oct 20; 30(30_suppl):94. PMID: 28142467.
    View in: PubMed
  31. Yovino SG, Savage WJ, Dulloor P, Grossman SA, Everett A. Pre- and postoperative plasma concentrations of five novel candidate biomarker proteins in patients with high- and low-grade gliomas. J Clin Oncol. 2012 Oct 20; 30(30_suppl):21. PMID: 28142446.
    View in: PubMed
  32. Savage WJ, Tobian AA, Savage JH, Wood RA, Schroeder JT, Ness PM. Scratching the surface of allergic transfusion reactions. Transfusion. 2013 Jun; 53(6):1361-71. PMID: 22998777; PMCID: PMC3711222.
  33. Frank SM, Savage WJ, Rothschild JA, Rivers RJ, Ness PM, Paul SL, Ulatowski JA. Variability in blood and blood component utilization as assessed by an anesthesia information management system. Anesthesiology. 2012 Jul; 117(1):99-106. PMID: 22531332.
    View in: PubMed
  34. George TJ, Beaty CA, Kilic A, Haggerty KA, Frank SM, Savage WJ, Whitman GJ. Hemoglobin drift after cardiac surgery. Ann Thorac Surg. 2012 Sep; 94(3):703-9. PMID: 22609121; PMCID: PMC3610599.
  35. Josephson CD, Granger S, Assmann SF, Castillejo MI, Strauss RG, Slichter SJ, Steiner ME, Journeycake JM, Thornburg CD, Bussel J, Grabowski EF, Neufeld EJ, Savage W, Sloan SR. Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia. Blood. 2012 Jul 26; 120(4):748-60. PMID: 22538854; PMCID: PMC3462047.
  36. Husain H, Savage W, Grossman SA, Ye X, Burger PC, Everett A, Bettegowda C, Diaz LA, Blair C, Romans KE, Holdhoff M. Pre- and post-operative plasma glial fibrillary acidic protein levels in patients with newly diagnosed gliomas. J Neurooncol. 2012 Aug; 109(1):123-7. PMID: 22492246; PMCID: PMC3715051.
  37. Karafin MS, Blagg L, Tobian AA, King KE, Ness PM, Savage WJ. ABO antibody titers are not predictive of hemolytic reactions due to plasma-incompatible platelet transfusions. Transfusion. 2012 Oct; 52(10):2087-93. PMID: 22339320; PMCID: PMC3360137.
  38. Karafin M, Fuller AK, Savage WJ, King KE, Ness PM, Tobian AA. The impact of apheresis platelet manipulation on corrected count increment. Transfusion. 2012 Jun; 52(6):1221-7. PMID: 22233358; PMCID: PMC3325359.
  39. Bembea MM, Savage W, Strouse JJ, Schwartz JM, Graham E, Thompson CB, Everett A. Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2011 Sep; 12(5):572-9. PMID: 21057367; PMCID: PMC3686089.
  40. Savage WJ, Savage JH, Tobian AA, Thoburn C, Hamilton RG, Schroeder JT, Ness PM. Allergic agonists in apheresis platelet products are associated with allergic transfusion reactions. Transfusion. 2012 Mar; 52(3):575-81. PMID: 21883267; PMCID: PMC3711211.
  41. Pu JJ, Mukhina G, Wang H, Savage WJ, Brodsky RA. Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia. Eur J Haematol. 2011 Jul; 87(1):37-45. PMID: 21447004; PMCID: PMC3120909.
  42. Ennen CS, Huisman TA, Savage WJ, Northington FJ, Jennings JM, Everett AD, Graham EM. Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling. Am J Obstet Gynecol. 2011 Sep; 205(3):251.e1-7. PMID: 21784396; PMCID: PMC4011017.
  43. Husain H, Savage W, Everett A, Ye X, Blair C, Romans KE, Bettegowda C, Burger P, Grossman SA, Holdhoff M. The role of plasma GFAP as a biomarker for glioblastoma. J Clin Oncol. 2011 May 20; 29(15_suppl):2095. PMID: 28019858.
    View in: PubMed
  44. Savage WJ, Tobian AA, Savage JH, Hamilton RG, Ness PM. Atopic predisposition of recipients in allergic transfusion reactions to apheresis platelets. Transfusion. 2011 Nov; 51(11):2337-42. PMID: 21569041; PMCID: PMC3711221.
  45. Savage WJ, Barron-Casella E, Fu Z, Dulloor P, Williams L, Crain BJ, White DA, Jennings JM, Van Eyk JE, Debaun MR, Everett A, Casella JF. Plasma glial fibrillary acidic protein levels in children with sickle cell disease. Am J Hematol. 2011 May; 86(5):427-9. PMID: 21523806; PMCID: PMC3870012.
  46. Tobian AA, Savage WJ, Tisch DJ, Thoman S, King KE, Ness PM. Prevention of allergic transfusion reactions to platelets and red blood cells through plasma reduction. Transfusion. 2011 Aug; 51(8):1676-83. PMID: 21214585.
    View in: PubMed
  47. Savage WJ, Tobian AA, Fuller AK, Wood RA, King KE, Ness PM. Allergic transfusion reactions to platelets are associated more with recipient and donor factors than with product attributes. Transfusion. 2011 Aug; 51(8):1716-22. PMID: 21214586; PMCID: PMC3137746.
  48. Savage WJ, Everett AD. Biomarkers in pediatrics: children as biomarker orphans. Proteomics Clin Appl. 2010 Dec; 4(12):915-21. PMID: 21137032.
    View in: PubMed
  49. Williams LM, Fu Z, Dulloor P, Yen T, Barron-Casella E, Savage W, Van Eyk JE, Casella JF, Everett A. Hemoglobin depletion from plasma: considerations for proteomic discovery in sickle cell disease and other hemolytic processes. Proteomics Clin Appl. 2010 Dec; 4(12):926-30. PMID: 21179892; PMCID: PMC4364410.
  50. Savage WJ, Everett AD, Casella JF. Plasma glial fibrillary acidic protein levels in a child with sickle cell disease and stroke. Acta Haematol. 2011; 125(3):103-6. PMID: 21099215; PMCID: PMC3202928.
  51. Tobian AA, Shirey RS, Savage WJ. Transfusion med illustrated: Ceftriaxone-induced acute hemolytic anemia. Transfusion. 2010 Aug; 50(8):1647-8. PMID: 20931689.
    View in: PubMed
  52. Janda A, Sedlacek P, Hönig M, Friedrich W, Champagne M, Matsumoto T, Fischer A, Neven B, Contet A, Bensoussan D, Bordigoni P, Loeb D, Savage W, Jabado N, Bonilla FA, Slatter MA, Davies EG, Gennery AR. Multicenter survey on the outcome of transplantation of hematopoietic cells in patients with the complete form of DiGeorge anomaly. Blood. 2010 Sep 30; 116(13):2229-36. PMID: 20530285; PMCID: PMC4425440.
  53. Fu Q, Schoenhoff FS, Savage WJ, Zhang P, Van Eyk JE. Multiplex assays for biomarker research and clinical application: translational science coming of age. Proteomics Clin Appl. 2010 Mar; 4(3):271-84. PMID: 21137048.
    View in: PubMed
  54. Fuller AK, Uglik KM, Savage WJ, Ness PM, King KE. Bacterial culture reduces but does not eliminate the risk of septic transfusion reactions to single-donor platelets. Transfusion. 2009 Dec; 49(12):2588-93. PMID: 19694995; PMCID: PMC3127255.
  55. Hoover-Fong J, Savage WJ, Lisi E, Winkelstein J, Thomas GH, Hoefsloot LH, Loeb DM. Congenital T cell deficiency in a patient with CHARGE syndrome. J Pediatr. 2009 Jan; 154(1):140-2. PMID: 19187738; PMCID: PMC4293037.
  56. Savage WJ, Barber JP, Mukhina GL, Hu R, Chen G, Matsui W, Thoburn C, Hess AD, Cheng L, Jones RJ, Brodsky RA. Glycosylphosphatidylinositol-anchored protein deficiency confers resistance to apoptosis in PNH. Exp Hematol. 2009 Jan; 37(1):42-51. PMID: 19013003; PMCID: PMC2628761.
  57. Savage WJ, DeRusso PA, Resar LM, Chen AR, Higman MA, Loeb DM, Jones RJ, Brodsky RA. Treatment of hepatitis-associated aplastic anemia with high-dose cyclophosphamide. Pediatr Blood Cancer. 2007 Dec; 49(7):947-51. PMID: 17252566.
    View in: PubMed
  58. Savage WJ, Kickler TS, Takemoto CM. Acquired coagulation factor inhibitors in children after topical bovine thrombin exposure. Pediatr Blood Cancer. 2007 Dec; 49(7):1025-9. PMID: 16526049.
    View in: PubMed
  59. Savage WJ, Brodsky RA. New insights into paroxysmal nocturnal hemoglobinuria. Hematology. 2007 Oct; 12(5):371-6. PMID: 17852463.
    View in: PubMed
  60. Bleesing JJ, Souto-Carneiro MM, Savage WJ, Brown MR, Martinez C, Yavuz S, Brenner S, Siegel RM, Horwitz ME, Lipsky PE, Malech HL, Fleisher TA. Patients with chronic granulomatous disease have a reduced peripheral blood memory B cell compartment. J Immunol. 2006 Jun 01; 176(11):7096-103. PMID: 16709872.
    View in: PubMed
  61. Savage WJ, Bleesing JJ, Douek D, Brown MR, Linton GM, Malech HL, Horwitz ME. Lymphocyte reconstitution following non-myeloablative hematopoietic stem cell transplantation follows two patterns depending on age and donor/recipient chimerism. Bone Marrow Transplant. 2001 Sep; 28(5):463-71. PMID: 11593319.
    View in: PubMed
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