Harvard Catalyst Profiles

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Jianhua Shi, Ph.D., M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shi J, Gu JH, Dai CL, Gu J, Jin X, Sun J, Iqbal K, Liu F, Gong CX. O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling. Sci Rep. 2015 Sep 28; 5:14500. PMID: 26412745.
    Citations: 36     Fields:    Translation:AnimalsCells
  2. Jin N, Yin X, Gu J, Zhang X, Shi J, Qian W, Ji Y, Cao M, Gu X, Ding F, Iqbal K, Gong CX, Liu F. Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE. J Biol Chem. 2015 Jun 12; 290(24):15219-37. PMID: 25918155; PMCID: PMC4463463.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  3. Wang Y, Yang R, Gu J, Yin X, Jin N, Xie S, Wang Y, Chang H, Qian W, Shi J, Iqbal K, Gong CX, Cheng C, Liu F. Cross talk between PI3K-AKT-GSK-3ß and PP2A pathways determines tau hyperphosphorylation. Neurobiol Aging. 2015 Jan; 36(1):188-200. PMID: 25219467.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  4. Preitner N, Quan J, Nowakowski DW, Hancock ML, Shi J, Tcherkezian J, Young-Pearse TL, Flanagan JG. APC is an RNA-binding protein, and its interactome provides a link to neural development and microtubule assembly. Cell. 2014 Jul 17; 158(2):368-382. PMID: 25036633.
    Citations: 85     Fields:    Translation:AnimalsCells
  5. Dai CL, Shi J, Chen Y, Iqbal K, Liu F, Gong CX. Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT). J Biol Chem. 2013 Aug 16; 288(33):23875-83. PMID: 23843462; PMCID: PMC3745334.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  6. Qian W, Jin N, Shi J, Yin X, Jin X, Wang S, Cao M, Iqbal K, Gong CX, Liu F. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression. J Alzheimers Dis. 2013; 37(3):529-38. PMID: 23948904.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  7. Liu Y, Li X, Yu Y, Shi J, Liang Z, Run X, Li Y, Dai CL, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain. PLoS One. 2012; 7(8):e43724. PMID: 22928023.
    Citations: 42     Fields:    Translation:AnimalsCells
  8. Yin X, Jin N, Gu J, Shi J, Zhou J, Gong CX, Iqbal K, Grundke-Iqbal I, Liu F. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion. J Biol Chem. 2012 Aug 31; 287(36):30497-506. PMID: 22767602; PMCID: PMC3436298.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  9. Shi J, Wu S, Dai CL, Li Y, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. Diverse regulation of AKT and GSK-3ß by O-GlcNAcylation in various types of cells. FEBS Lett. 2012 Jul 30; 586(16):2443-50. PMID: 22687243.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  10. Gu J, Shi J, Wu S, Jin N, Qian W, Zhou J, Iqbal IG, Iqbal K, Gong CX, Liu F. Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10. FEBS Lett. 2012 Jul 30; 586(16):2239-44. PMID: 22677170.
    Citations: 8     Fields:    Translation:HumansCells
  11. Qian W, Liang H, Shi J, Jin N, Grundke-Iqbal I, Iqbal K, Gong CX, Liu F. Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A. Nucleic Acids Res. 2011 Aug; 39(14):6161-71. PMID: 21470964; PMCID: PMC3152345.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  12. Shi J, Qian W, Yin X, Iqbal K, Grundke-Iqbal I, Gu X, Ding F, Gong CX, Liu F. Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease. J Biol Chem. 2011 Apr 22; 286(16):14639-48. PMID: 21367856.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  13. Ding S, Shi J, Qian W, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A. Neurobiol Aging. 2012 Jul; 33(7):1389-99. PMID: 21215488; PMCID: PMC3085640.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  14. Qian W, Yin X, Hu W, Shi J, Gu J, Grundke-Iqbal I, Iqbal K, Gong CX, Liu F. Activation of protein phosphatase 2B and hyperphosphorylation of Tau in Alzheimer's disease. J Alzheimers Dis. 2011; 23(4):617-27. PMID: 21157033.
    Citations: 19     Fields:    Translation:HumansCells
  15. Qian W, Shi J, Yin X, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. J Alzheimers Dis. 2010; 19(4):1221-9. PMID: 20308788.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  16. Liu F, Shi J, Tanimukai H, Gu J, Gu J, Grundke-Iqbal I, Iqbal K, Gong CX. Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain. 2009 Jul; 132(Pt 7):1820-32. PMID: 19451179; PMCID: PMC2702834.
    Citations: 155     Fields:    Translation:HumansCells
  17. Shi J, Zhang T, Zhou C, Chohan MO, Gu X, Wegiel J, Zhou J, Hwang YW, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome. J Biol Chem. 2008 Oct 17; 283(42):28660-9. PMID: 18658135; PMCID: PMC2568927.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  18. Liu F, Liang Z, Shi J, Yin D, El-Akkad E, Grundke-Iqbal I, Iqbal K, Gong CX. PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners. FEBS Lett. 2006 Nov 13; 580(26):6269-74. PMID: 17078951; PMCID: PMC1828604.
    Citations: 56     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.