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Ryuji Morizane, Ph.D., M.D.


2011 - 2013
Grant-in-Aid for Research Activity Start-up
2012 - 2013
Research Fellowship for Research Abroad
2013 - 2015
Grant-in-Aid for JSPS Postdoctoral Fellowship for Research Abroad
Research Excellence Award
2015 - 2016
Innovative Research Grant
2016 - 2017
Faculty Career Development Award
2016 - 2018
HSCI seed grant

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N, Miyoshi T, Susa K, Johnson BG, Soliman K, Wang G, Morizane R, Bonventre JV, Duffield JS. Interleukin-1ß Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis. J Am Soc Nephrol. 2018 Jun; 29(6):1690-1705. PMID: 29739813.
    View in: PubMed
  2. Morizane R, Miyoshi T, Bonventre JV. Concise Review: Kidney Generation with Human Pluripotent Stem Cells. Stem Cells. 2017 Nov; 35(11):2209-2217. PMID: 28869686.
    View in: PubMed
  3. Gupta N, Susa K, Morizane R. Regenerative Medicine, Disease Modelling, and Drug Discovery in Human Pluripotent Stem Cell-Derived Kidney Tissue. EMJ Repro Health. 2017; 1(3):57-67.
  4. Morizane R, Bonventre JV. Kidney Organoids: A Translational Journey. Trends Mol Med. 2017 03; 23(3):246-263. PMID: 28188103.
    View in: PubMed
  5. Morizane R, Bonventre JV. Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells. Nat Protoc. 2017 Jan; 12(1):195-207. PMID: 28005067.
    View in: PubMed
  6. Yamaguchi S, Morizane R, Homma K, Monkawa T, Suzuki S, Fujii S, Koda M, Hiratsuka K, Yamashita M, Yoshida T, Wakino S, Hayashi K, Sasaki J, Hori S, Itoh H. Generation of kidney tubular organoids from human pluripotent stem cells. Sci Rep. 2016 12 16; 6:38353. PMID: 27982115.
    View in: PubMed
  7. Morizane R, Lam AQ, Freedman BS, Kishi S, Valerius MT, Bonventre JV. Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat Biotechnol. 2015 Nov; 33(11):1193-200. PMID: 26458176; PMCID: PMC4747858.
  8. Freedman BS, Brooks CR, Lam AQ, Fu H, Morizane R, Agrawal V, Saad AF, Li MK, Hughes MR, Werff RV, Peters DT, Lu J, Baccei A, Siedlecki AM, Valerius MT, Musunuru K, McNagny KM, Steinman TI, Zhou J, Lerou PH, Bonventre JV. Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nat Commun. 2015 Oct 23; 6:8715. PMID: 26493500; PMCID: PMC4620584.
  9. Morizane R, Fujii S, Monkawa T, Hiratsuka K, Yamaguchi S, Homma K, Itoh H. miR-363 induces transdifferentiation of human kidney tubular cells to mesenchymal phenotype. Clin Exp Nephrol. 2016 Jun; 20(3):394-401. PMID: 26373846.
    View in: PubMed
  10. Morizane R, Lam AQ. Directed Differentiation of Pluripotent Stem Cells into Kidney. Biomark Insights. 2015; 10(Suppl 1):147-52. PMID: 26417199; PMCID: PMC4571990.
  11. Kishi S, Campanholle G, Gohil VM, Perocchi F, Brooks CR, Morizane R, Sabbisetti V, Ichimura T, Mootha VK, Bonventre JV. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015 Sep; 2(9):1090-101. PMID: 26501107; PMCID: PMC4588407.
  12. Morizane R, Fujii S, Monkawa T, Hiratsuka K, Yamaguchi S, Homma K, Itoh H. miR-34c attenuates epithelial-mesenchymal transition and kidney fibrosis with ureteral obstruction. Sci Rep. 2014 Apr 03; 4:4578. PMID: 24694752; PMCID: PMC3974136.
  13. Lam AQ, Freedman BS, Morizane R, Lerou PH, Valerius MT, Bonventre JV. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol. 2014 Jun; 25(6):1211-25. PMID: 24357672; PMCID: PMC4033376.
  14. Morizane R, Monkawa T, Fujii S, Yamaguchi S, Homma K, Matsuzaki Y, Okano H, Itoh H. Kidney specific protein-positive cells derived from embryonic stem cells reproduce tubular structures in vitro and differentiate into renal tubular cells. PLoS One. 2014; 8(6):e64843. PMID: 23755150; PMCID: PMC3670839.
  15. Morizane R, Konishi K, Hashiguchi A, Tokuyama H, Wakino S, Kawabe H, Hayashi M, Hayashi K, Itoh H. MPO-ANCA associated crescentic glomerulonephritis with numerous immune complexes: case report. BMC Nephrol. 2012 Jun 01; 13:32. PMID: 22656245; PMCID: PMC3470990.
  16. Yamaguchi S, Yamahara K, Homma K, Suzuki S, Fujii S, Morizane R, Monkawa T, Matsuzaki Y, Kangawa K, Itoh H. The role of microRNA-145 in human embryonic stem cell differentiation into vascular cells. Atherosclerosis. 2011 Dec; 219(2):468-74. PMID: 21945499.
    View in: PubMed
  17. Morizane R, Monkawa T, Konishi K, Hashiguchi A, Ueda M, Ando Y, Tokuyama H, Hayashi K, Hayashi M, Itoh H. Renal amyloidosis caused by apolipoprotein A-II without a genetic mutation in the coding sequence. Clin Exp Nephrol. 2011 Oct; 15(5):774-779. PMID: 21728005.
    View in: PubMed
  18. Sekine M, Monkawa T, Morizane R, Matsuoka K, Taya C, Akita Y, Joh K, Itoh H, Hayashi M, Kikkawa Y, Kohno K, Suzuki A, Yonekawa H. Selective depletion of mouse kidney proximal straight tubule cells causes acute kidney injury. Transgenic Res. 2012 Feb; 21(1):51-62. PMID: 21431867; PMCID: PMC3264875.
  19. Morizane R, Monkawa T, Itoh H. Differentiation of murine embryonic stem and induced pluripotent stem cells to renal lineage in vitro. Biochem Biophys Res Commun. 2009 Dec 25; 390(4):1334-9. PMID: 19883625.
    View in: PubMed
  20. Morizane R, Sasamura H, Minakuchi H, Takae Y, Kikuchi H, Yoshiya N, Hashiguchi A, Konishi K, Okamoto S, Itoh H. A case of atypical POEMS syndrome without polyneuropathy. Eur J Haematol. 2008 May; 80(5):452-5. PMID: 18284621.
    View in: PubMed
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