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Ryuji Morizane, Ph.D., M.D.

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Biography
2011
Travel Award
2015
Research Excellence Award
2016 - 2017
Faculty Career Development Award
2016
Research Excellence Award

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. (Ryuji Morizane) Nov 1, 2017 - Oct 31, 2018
    Diabetic Complications Consortium
    Modeling Diabetic Kidney Fibrosis with Kidney Organoids derived from Human Pluripotent Stem Cells
    Role: Principal Investigator
  2. (David Mount) Sep 1, 2017 - Aug 31, 2022
    NIH
    Translational genomics of hyperuricemia and its causality with chronic kidney disease
    Role: Co-Investigator
  3. UG3TR002155 (BONVENTRE, JOSEPH VINCENT) Jul 25, 2017 - Jun 30, 2019
    NIH/NCATS
    Kidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model Disease
    Role: Co-Investigator
  4. UM1HG009390 (BERNSTEIN, BRADLEY EVAN) Feb 1, 2017 - Jan 31, 2021
    NIH/NHGRI
    A Catalog of Cell Types and Genomic Elements in Tissues, Organoids and Disease
    Role: Co-Investigator
  5. (Ryuji Morizane) Dec 1, 2016 - Nov 30, 2018
    AJINOMOTO Col., Inc
    Development of high efficient and quality controlled culture methods for producing specific aimed cells from hPSCs with gene-editing technology
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hill SJ, Decker B, Roberts EA, Horowitz NS, Muto MG, Worley MJ, Feltmate CM, Nucci MR, Swisher EM, Nguyen H, Yang C, Morizane R, Kochupurakkal BS, Do KT, Konstantinopoulos PA, Liu JF, Bonventre JV, Matulonis UA, Shapiro GI, Berkowitz RS, Crum CP, D'Andrea AD. Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids. Cancer Discov. 2018 Nov; 8(11):1404-1421. PMID: 30213835.
    View in: PubMed
  2. Ryuji Morizane, Joseph V Bonventre. Organoids for modeling kidney disease. Organs and Organoids. 2018; 227-245.
  3. Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N, Miyoshi T, Susa K, Johnson BG, Soliman K, Wang G, Morizane R, Bonventre JV, Duffield JS. Interleukin-1ß Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis. J Am Soc Nephrol. 2018 Jun; 29(6):1690-1705. PMID: 29739813.
    View in: PubMed
  4. Gupta N, Susa K, Yoda Y, Bonventre JV, Valerius MT, Morizane R. CRISPR/Cas9-based Targeted Genome Editing for the Development of Monogenic Diseases Models with Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2018 May; 45(1):e50. PMID: 30040245.
    View in: PubMed
  5. Morizane R, Miyoshi T, Bonventre JV. Concise Review: Kidney Generation with Human Pluripotent Stem Cells. Stem Cells. 2017 11; 35(11):2209-2217. PMID: 28869686.
    View in: PubMed
  6. Gupta N, Susa K, Morizane R. Regenerative Medicine, Disease Modelling, and Drug Discovery in Human Pluripotent Stem Cell-Derived Kidney Tissue. EMJ Repro Health. 2017; 1(3):57-67.
  7. Morizane R, Bonventre JV. Kidney Organoids: A Translational Journey. Trends Mol Med. 2017 03; 23(3):246-263. PMID: 28188103.
    View in: PubMed
  8. Morizane R, Bonventre JV. Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells. Nat Protoc. 2017 Jan; 12(1):195-207. PMID: 28005067.
    View in: PubMed
  9. Yamaguchi S, Morizane R, Homma K, Monkawa T, Suzuki S, Fujii S, Koda M, Hiratsuka K, Yamashita M, Yoshida T, Wakino S, Hayashi K, Sasaki J, Hori S, Itoh H. Generation of kidney tubular organoids from human pluripotent stem cells. Sci Rep. 2016 12 16; 6:38353. PMID: 27982115.
    View in: PubMed
  10. Morizane R, Lam AQ, Freedman BS, Kishi S, Valerius MT, Bonventre JV. Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat Biotechnol. 2015 Nov; 33(11):1193-200. PMID: 26458176; PMCID: PMC4747858.
  11. Freedman BS, Brooks CR, Lam AQ, Fu H, Morizane R, Agrawal V, Saad AF, Li MK, Hughes MR, Werff RV, Peters DT, Lu J, Baccei A, Siedlecki AM, Valerius MT, Musunuru K, McNagny KM, Steinman TI, Zhou J, Lerou PH, Bonventre JV. Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nat Commun. 2015 Oct 23; 6:8715. PMID: 26493500; PMCID: PMC4620584.
  12. Morizane R, Fujii S, Monkawa T, Hiratsuka K, Yamaguchi S, Homma K, Itoh H. miR-363 induces transdifferentiation of human kidney tubular cells to mesenchymal phenotype. Clin Exp Nephrol. 2016 Jun; 20(3):394-401. PMID: 26373846.
    View in: PubMed
  13. Morizane R, Lam AQ. Directed Differentiation of Pluripotent Stem Cells into Kidney. Biomark Insights. 2015; 10(Suppl 1):147-52. PMID: 26417199; PMCID: PMC4571990.
  14. Kishi S, Campanholle G, Gohil VM, Perocchi F, Brooks CR, Morizane R, Sabbisetti V, Ichimura T, Mootha VK, Bonventre JV. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015 Sep; 2(9):1090-101. PMID: 26501107; PMCID: PMC4588407.
  15. Morizane R, Fujii S, Monkawa T, Hiratsuka K, Yamaguchi S, Homma K, Itoh H. miR-34c attenuates epithelial-mesenchymal transition and kidney fibrosis with ureteral obstruction. Sci Rep. 2014 Apr 03; 4:4578. PMID: 24694752; PMCID: PMC3974136.
  16. Lam AQ, Freedman BS, Morizane R, Lerou PH, Valerius MT, Bonventre JV. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol. 2014 Jun; 25(6):1211-25. PMID: 24357672; PMCID: PMC4033376.
  17. Morizane R, Monkawa T, Fujii S, Yamaguchi S, Homma K, Matsuzaki Y, Okano H, Itoh H. Kidney specific protein-positive cells derived from embryonic stem cells reproduce tubular structures in vitro and differentiate into renal tubular cells. PLoS One. 2014; 8(6):e64843. PMID: 23755150; PMCID: PMC3670839.
  18. Morizane R, Konishi K, Hashiguchi A, Tokuyama H, Wakino S, Kawabe H, Hayashi M, Hayashi K, Itoh H. MPO-ANCA associated crescentic glomerulonephritis with numerous immune complexes: case report. BMC Nephrol. 2012 Jun 01; 13:32. PMID: 22656245; PMCID: PMC3470990.
  19. Yamaguchi S, Yamahara K, Homma K, Suzuki S, Fujii S, Morizane R, Monkawa T, Matsuzaki Y, Kangawa K, Itoh H. The role of microRNA-145 in human embryonic stem cell differentiation into vascular cells. Atherosclerosis. 2011 Dec; 219(2):468-74. PMID: 21945499.
    View in: PubMed
  20. Morizane R, Monkawa T, Konishi K, Hashiguchi A, Ueda M, Ando Y, Tokuyama H, Hayashi K, Hayashi M, Itoh H. Renal amyloidosis caused by apolipoprotein A-II without a genetic mutation in the coding sequence. Clin Exp Nephrol. 2011 Oct; 15(5):774-779. PMID: 21728005.
    View in: PubMed
  21. Sekine M, Monkawa T, Morizane R, Matsuoka K, Taya C, Akita Y, Joh K, Itoh H, Hayashi M, Kikkawa Y, Kohno K, Suzuki A, Yonekawa H. Selective depletion of mouse kidney proximal straight tubule cells causes acute kidney injury. Transgenic Res. 2012 Feb; 21(1):51-62. PMID: 21431867; PMCID: PMC3264875.
  22. Morizane R, Monkawa T, Itoh H. Differentiation of murine embryonic stem and induced pluripotent stem cells to renal lineage in vitro. Biochem Biophys Res Commun. 2009 Dec 25; 390(4):1334-9. PMID: 19883625.
    View in: PubMed
  23. Morizane R, Sasamura H, Minakuchi H, Takae Y, Kikuchi H, Yoshiya N, Hashiguchi A, Konishi K, Okamoto S, Itoh H. A case of atypical POEMS syndrome without polyneuropathy. Eur J Haematol. 2008 May; 80(5):452-5. PMID: 18284621.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.