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Daniel Graham, Ph.D.

Title
Institution
Department
Address
Phone

Biography
Bates College, Lewiston, MEBS05/1998Biochemistry
Mayo Clinic College of Medicine, Rochester, MNPhD05/2005Immunology
Washington University School of Medicine, St. Louis, MOPostdoc02/2012Immunobiology

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Pedersen TK, Brown EM, Plichta DR, Johansen J, Twardus SW, Delorey TM, Lau H, Vlamakis H, Moon JJ, Xavier RJ, Graham DB. The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn's disease. Immunity. 2022 10 11; 55(10):1909-1923.e6. PMID: 36115338.
    Citations: 1     Fields:    Translation:HumansCells
  2. Lang AE, Siderowf AD, Macklin EA, Poewe W, Brooks DJ, Fernandez HH, Rascol O, Giladi N, Stocchi F, Tanner CM, Postuma RB, Simon DK, Tolosa E, Mollenhauer B, Cedarbaum JM, Fraser K, Xiao J, Evans KC, Graham DL, Sapir I, Inra J, Hutchison RM, Yang M, Fox T, Budd Haeberlein S, Dam T. Trial of Cinpanemab in Early Parkinson's Disease. N Engl J Med. 2022 08 04; 387(5):408-420. PMID: 35921450.
    Citations: 5     Fields:    Translation:Humans
  3. Bae M, Cassilly CD, Liu X, Park SM, Tusi BK, Chen X, Kwon J, Filipcík P, Bolze AS, Liu Z, Vlamakis H, Graham DB, Buhrlage SJ, Xavier RJ, Clardy J. Akkermansia muciniphila phospholipid induces homeostatic immune responses. Nature. 2022 08; 608(7921):168-173. PMID: 35896748; PMCID: PMC9328018.
    Citations:    Fields:    
  4. Chen X, Jaiswal A, Costliow Z, Herbst P, Creasey EA, Oshiro-Rapley N, Daly MJ, Carey KL, Graham DB, Xavier RJ. pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells. Nat Immunol. 2022 07; 23(7):1063-1075. PMID: 35668320; PMCID: PMC9720675.
    Citations:    Fields:    Translation:AnimalsCells
  5. Mealer RG, Williams SE, Noel M, Yang B, D'Souza AK, Nakata T, Graham DB, Creasey EA, Cetinbas M, Sadreyev RI, Scolnick EM, Woo CM, Smoller JW, Xavier RJ, Cummings RD. The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain. Mol Psychiatry. 2022 03; 27(3):1405-1415. PMID: 35260802; PMCID: PMC9106890.
    Citations:    Fields:    Translation:AnimalsCells
  6. Szamosvári D, Bae M, Bang S, Tusi BK, Cassilly CD, Park SM, Graham DB, Xavier RJ, Clardy J. Lyme Disease, Borrelia burgdorferi, and Lipid Immunogens. J Am Chem Soc. 2022 02 16; 144(6):2474-2478. PMID: 35129341.
    Citations:    Fields:    Translation:AnimalsCells
  7. Jasso GJ, Jaiswal A, Varma M, Laszewski T, Grauel A, Omar A, Silva N, Dranoff G, Porter JA, Mansfield K, Cremasco V, Regev A, Xavier RJ, Graham DB. Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing. PLoS Biol. 2022 01; 20(1):e3001532. PMID: 35085231; PMCID: PMC8824371.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Ke X, You K, Pichaud M, Haiser HJ, Graham DB, Vlamakis H, Porter JA, Xavier RJ. Gut bacterial metabolites modulate endoplasmic reticulum stress. Genome Biol. 2021 10 15; 22(1):292. PMID: 34654459; PMCID: PMC8518294.
    Citations: 1     Fields:    Translation:HumansCells
  9. Dam T, Boxer AL, Golbe LI, Höglinger GU, Morris HR, Litvan I, Lang AE, Corvol JC, Aiba I, Grundman M, Yang L, Tidemann-Miller B, Kupferman J, Harper K, Kamisoglu K, Wald MJ, Graham DL, Gedney L, O'Gorman J, Haeberlein SB. Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial. Nat Med. 2021 08; 27(8):1451-1457. PMID: 34385707.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  10. Liu K, Kong L, Graham DB, Carey KL, Xavier RJ. SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance. Cell Rep. 2021 07 27; 36(4):109434. PMID: 34320354; PMCID: PMC8327279.
    Citations: 2     Fields:    Translation:HumansCells
  11. Taylor HB, Klaeger S, Clauser KR, Sarkizova S, Weingarten-Gabbay S, Graham DB, Carr SA, Abelin JG. MS-Based HLA-II Peptidomics Combined With Multiomics Will Aid the Development of Future Immunotherapies. Mol Cell Proteomics. 2021; 20:100116. PMID: 34146720; PMCID: PMC8327157.
    Citations: 1     Fields:    Translation:HumansAnimals
  12. Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ. B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV. Cell. 2021 06 10; 184(12):3205-3221.e24. PMID: 34015271; PMCID: PMC8064835.
    Citations: 21     Fields:    Translation:HumansCells
  13. Rojas JC, Wang P, Staffaroni AM, Heller C, Cobigo Y, Wolf A, Goh SM, Ljubenkov PA, Heuer HW, Fong JC, Taylor JB, Veras E, Song L, Jeromin A, Hanlon D, Yu L, Khinikar A, Sivasankaran R, Kieloch A, Valentin MA, Karydas AM, Mitic LL, Pearlman R, Kornak J, Kramer JH, Miller BL, Kantarci K, Knopman DS, Graff-Radford N, Petrucelli L, Rademakers R, Irwin DJ, Grossman M, Ramos EM, Coppola G, Mendez MF, Bordelon Y, Dickerson BC, Ghoshal N, Huey ED, Mackenzie IR, Appleby BS, Domoto-Reilly K, Hsiung GR, Toga AW, Weintraub S, Kaufer DI, Kerwin D, Litvan I, Onyike CU, Pantelyat A, Roberson ED, Tartaglia MC, Foroud T, Chen W, Czerkowicz J, Graham DL, van Swieten JC, Borroni B, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Synofzik M, Galimberti D, Rowe JB, Masellis M, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Otto M, Sorbi S, Cash DM, Convery RS, Bocchetta M, Foiani M, Greaves CV, Peakman G, Russell L, Swift I, Todd E, Rohrer JD, Boeve BF, Rosen HJ, Boxer AL. Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration. Neurology. 2021 05 04; 96(18):e2296-e2312. PMID: 33827960; PMCID: PMC8166434.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  14. You K, Wang L, Chou CH, Liu K, Nakata T, Jaiswal A, Yao J, Lefkovith A, Omar A, Perrigoue JG, Towne JE, Regev A, Graham DB, Xavier RJ. QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis. Science. 2021 01 01; 371(6524). PMID: 33384352; PMCID: PMC8315080.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  15. Nakata T, Creasey EA, Kadoki M, Lin H, Selig MK, Yao J, Lefkovith A, Daly MJ, Graham DB, Xavier RJ. A missense variant in SLC39A8 confers risk for Crohn's disease by disrupting manganese homeostasis and intestinal barrier integrity. Proc Natl Acad Sci U S A. 2020 11 17; 117(46):28930-28938. PMID: 33139556.
    Citations: 7     Fields:    Translation:HumansAnimals
  16. Xu W, Rush JS, Graham DB, Cao Z, Xavier RJ. USP15 Deubiquitinates CARD9 to Downregulate C-Type Lectin Receptor-Mediated Signaling. Immunohorizons. 2020 10 22; 4(10):670-678. PMID: 33093067.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  17. Sopko R, Golonzhka O, Arndt J, Quan C, Czerkowicz J, Cameron A, Smith B, Murugesan Y, Gibbons G, Kim SJ, Trojanowski JQ, Lee VMY, Brunden KR, Graham DL, Weinreb PH, Hering H. Characterization of tau binding by gosuranemab. Neurobiol Dis. 2020 12; 146:105120. PMID: 32991997.
    Citations: 11     Fields:    Translation:AnimalsCells
  18. Varma M, Kadoki M, Lefkovith A, Conway KL, Gao K, Mohanan V, Tusi BK, Graham DB, Latorre IJ, Tolonen AC, Khor B, Ng A, Xavier RJ. Cell Type- and Stimulation-Dependent Transcriptional Programs Regulated by Atg16L1 and Its Crohn's Disease Risk Variant T300A. J Immunol. 2020 07 15; 205(2):414-424. PMID: 32522834; PMCID: PMC7364322.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  19. Mabrouk OS, Chen S, Edwards AL, Yang M, Hirst WD, Graham DL. Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients. Front Neurosci. 2020; 14:526. PMID: 32523511; PMCID: PMC7262382.
    Citations: 7     
  20. Graham DB, Xavier RJ. Pathway paradigms revealed from the genetics of inflammatory bowel disease. Nature. 2020 02; 578(7796):527-539. PMID: 32103191; PMCID: PMC7871366.
    Citations: 108     Fields:    Translation:HumansAnimals
  21. Xu H, Ding J, Porter CBM, Wallrapp A, Tabaka M, Ma S, Fu S, Guo X, Riesenfeld SJ, Su C, Dionne D, Nguyen LT, Lefkovith A, Ashenberg O, Burkett PR, Shi HN, Rozenblatt-Rosen O, Graham DB, Kuchroo VK, Regev A, Xavier RJ. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide a-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 10 15; 51(4):696-708.e9. PMID: 31618654.
    Citations: 57     Fields:    Translation:AnimalsCells
  22. Plichta DR, Graham DB, Subramanian S, Xavier RJ. Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships. Cell. 2019 08 22; 178(5):1041-1056. PMID: 31442399.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  23. Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, Herbst RH, Rogel N, Slyper M, Waldman J, Sud M, Andrews E, Velonias G, Haber AL, Jagadeesh K, Vickovic S, Yao J, Stevens C, Dionne D, Nguyen LT, Villani AC, Hofree M, Creasey EA, Huang H, Rozenblatt-Rosen O, Garber JJ, Khalili H, Desch AN, Daly MJ, Ananthakrishnan AN, Shalek AK, Xavier RJ, Regev A. Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis. Cell. 2019 07 25; 178(3):714-730.e22. PMID: 31348891.
    Citations: 246     Fields:    Translation:HumansCells
  24. Ansaldo E, Slayden LC, Ching KL, Koch MA, Wolf NK, Plichta DR, Brown EM, Graham DB, Xavier RJ, Moon JJ, Barton GM. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis. Science. 2019 06 21; 364(6446):1179-1184. PMID: 31221858; PMCID: PMC6645389.
    Citations: 107     Fields:    Translation:AnimalsCells
  25. Brown EM, Ke X, Hitchcock D, Jeanfavre S, Avila-Pacheco J, Nakata T, Arthur TD, Fornelos N, Heim C, Franzosa EA, Watson N, Huttenhower C, Haiser HJ, Dillow G, Graham DB, Finlay BB, Kostic AD, Porter JA, Vlamakis H, Clish CB, Xavier RJ. Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis. Cell Host Microbe. 2019 05 08; 25(5):668-680.e7. PMID: 31071294; PMCID: PMC6544385.
    Citations: 80     Fields:    Translation:AnimalsCells
  26. Schindler SE, Li Y, Todd KW, Herries EM, Henson RL, Gray JD, Wang G, Graham DL, Shaw LM, Trojanowski JQ, Hassenstab JJ, Benzinger TLS, Cruchaga C, Jucker M, Levin J, Chhatwal JP, Noble JM, Ringman JM, Graff-Radford NR, Holtzman DM, Ladenson JH, Morris JC, Bateman RJ, Xiong C, Fagan AM. Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease. Alzheimers Dement. 2019 05; 15(5):655-665. PMID: 30846386; PMCID: PMC6511459.
    Citations: 36     Fields:    Translation:Humans
  27. Angerer TB, Chakravarty N, Taylor MJ, Nicora CD, Graham DJ, Anderton CR, Chudler EH, Gamble LJ. Insights into the histology of planarian flatworm Phagocata gracilis based on location specific, intact lipid information provided by GCIB-ToF-SIMS imaging. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 05; 1864(5):733-743. PMID: 30731132; PMCID: PMC6506226.
    Citations: 3     Fields:    Translation:Animals
  28. Uniken Venema WT, Voskuil MD, Vila AV, van der Vries G, Jansen BH, Jabri B, Faber KN, Dijkstra G, Xavier RJ, Wijmenga C, Graham DB, Weersma RK, Festen EA. Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets. Gastroenterology. 2019 02; 156(3):812-815.e22. PMID: 30391472; PMCID: PMC6759855.
    Citations: 20     Fields:    Translation:HumansCells
  29. Biton M, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Z, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen O, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ. T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation. Cell. 2018 11 15; 175(5):1307-1320.e22. PMID: 30392957.
    Citations: 158     Fields:    Translation:AnimalsCells
  30. Graham DB, Luo C, O'Connell DJ, Lefkovith A, Brown EM, Yassour M, Varma M, Abelin JG, Conway KL, Jasso GJ, Matar CG, Carr SA, Xavier RJ. Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes. Nat Med. 2018 11; 24(11):1762-1772. PMID: 30349087; PMCID: PMC6312190.
    Citations: 19     Fields:    Translation:HumansCells
  31. Graham DB, Jasso GJ, Mok A, Goel G, Ng ACY, Kolde R, Varma M, Doench JG, Root DE, Clish CB, Carr SA, Xavier RJ. Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes. Cell Rep. 2018 07 24; 24(4):838-850. PMID: 30044981.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  32. Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM, Kurki M, Ganna A, Graham D, Glaser B, Peter I, Atzmon G, Barzilai N, Levine AP, Schiff E, Pontikos N, Weisburd B, Lek M, Karczewski KJ, Bloom J, Minikel EV, Petersen BS, Beaugerie L, Seksik P, Cosnes J, Schreiber S, Bokemeyer B, Bethge J, Heap G, Ahmad T, Plagnol V, Segal AW, Targan S, Turner D, Saavalainen P, Farkkila M, Kontula K, Palotie A, Brant SR, Duerr RH, Silverberg MS, Rioux JD, Weersma RK, Franke A, Jostins L, Anderson CA, Barrett JC, MacArthur DG, Jalas C, Sokol H, Xavier RJ, Pulver A, Cho JH, McGovern DPB, Daly MJ. Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population. PLoS Genet. 2018 05; 14(5):e1007329. PMID: 29795570.
    Citations: 26     Fields:    Translation:Humans
  33. Gorski Findling MT, Werth PM, Musicus AA, Bragg MA, Graham DJ, Elbel B, Roberto CA. Comparing five front-of-pack nutrition labels' influence on consumers' perceptions and purchase intentions. Prev Med. 2018 01; 106:114-121. PMID: 29066375; PMCID: PMC5764801.
    Citations: 15     Fields:    Translation:HumansPHPublic Health
  34. Leshchiner ES, Rush JS, Durney MA, Cao Z, Dancík V, Chittick B, Wu H, Petrone A, Bittker JA, Phillips A, Perez JR, Shamji AF, Kaushik VK, Daly MJ, Graham DB, Schreiber SL, Xavier RJ. Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):11392-11397. PMID: 29073062; PMCID: PMC5664502.
    Citations: 22     Fields:    Translation:HumansCells
  35. Johannessen L, Sundberg TB, O'Connell DJ, Kolde R, Berstler J, Billings KJ, Khor B, Seashore-Ludlow B, Fassl A, Russell CN, Latorre IJ, Jiang B, Graham DB, Perez JR, Sicinski P, Phillips AJ, Schreiber SL, Gray NS, Shamji AF, Xavier RJ. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat Chem Biol. 2017 Oct; 13(10):1102-1108. PMID: 28805801; PMCID: PMC5693369.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  36. Graham DB, Lefkovith A, Deelen P, de Klein N, Varma M, Boroughs A, Desch AN, Ng ACY, Guzman G, Schenone M, Petersen CP, Bhan AK, Rivas MA, Daly MJ, Carr SA, Wijmenga C, Xavier RJ. TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation. Cell Rep. 2016 12 13; 17(11):2955-2965. PMID: 27974209.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  37. Rivas MA, Graham D, Sulem P, Stevens C, Desch AN, Goyette P, Gudbjartsson D, Jonsdottir I, Thorsteinsdottir U, Degenhardt F, Mucha S, Kurki MI, Li D, D'Amato M, Annese V, Vermeire S, Weersma RK, Halfvarson J, Paavola-Sakki P, Lappalainen M, Lek M, Cummings B, Tukiainen T, Haritunians T, Halme L, Koskinen LL, Ananthakrishnan AN, Luo Y, Heap GA, Visschedijk MC, MacArthur DG, Neale BM, Ahmad T, Anderson CA, Brant SR, Duerr RH, Silverberg MS, Cho JH, Palotie A, Saavalainen P, Kontula K, Färkkilä M, McGovern DP, Franke A, Stefansson K, Rioux JD, Xavier RJ, Daly MJ, Barrett J, de Lane K, Edwards C, Hart A, Hawkey C, Jostins L, Kennedy N, Lamb C, Lee J, Lees C, Mansfield J, Mathew C, Mowatt C, Newman B, Nimmo E, Parkes M, Pollard M, Prescott N, Randall J, Rice D, Satsangi J, Simmons A, Tremelling M, Uhlig H, Wilson D, Abraham C, Achkar JP, Bitton A, Boucher G, Croitoru K, Fleshner P, Glas J, Kugathasan S, Limbergen JV, Milgrom R, Proctor D, Regueiro M, Schumm PL, Sharma Y, Stempak JM, Targan SR, Wang MH. A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis. Nat Commun. 2016 08 09; 7:12342. PMID: 27503255; PMCID: PMC4980482.
    Citations: 22     Fields:    Translation:Humans
  38. Netea MG, Joosten LA, Li Y, Kumar V, Oosting M, Smeekens S, Jaeger M, Ter Horst R, Schirmer M, Vlamakis H, Notebaart R, Pavelka N, Aguirre-Gamboa RR, Swertz MA, Tunjungputri RN, van de Heijden W, Franzosa EA, Ng A, Graham D, Lassen K, Schraa K, Netea-Maier R, Smit J, de Mast Q, van de Veerdonk F, Kullberg BJ, Tack C, van de Munckhof I, Rutten J, van der Graaf J, Franke L, Hofker M, Jonkers I, Platteel M, Maatman A, Fu J, Zhernakova A, van der Meer JW, Dinarello CA, van der Ven A, Huttenhouwer C, Koenen H, Joosten I, Xavier RJ, Wijmenga C. Understanding human immune function using the resources from the Human Functional Genomics Project. Nat Med. 2016 08 04; 22(8):831-3. PMID: 27490433.
    Citations: 28     Fields:    Translation:Humans
  39. Sundberg TB, Liang Y, Wu H, Choi HG, Kim ND, Sim T, Johannessen L, Petrone A, Khor B, Graham DB, Latorre IJ, Phillips AJ, Schreiber SL, Perez J, Shamji AF, Gray NS, Xavier RJ. Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo. ACS Chem Biol. 2016 08 19; 11(8):2105-11. PMID: 27224444; PMCID: PMC4992440.
    Citations: 24     Fields:    Translation:AnimalsCells
  40. deQuilettes DW, Zhang W, Burlakov VM, Graham DJ, Leijtens T, Osherov A, Bulovic V, Snaith HJ, Ginger DS, Stranks SD. Photo-induced halide redistribution in organic-inorganic perovskite films. Nat Commun. 2016 05 24; 7:11683. PMID: 27216703; PMCID: PMC4890321.
    Citations: 62     Fields:    
  41. O'Connell DJ, Kolde R, Sooknah M, Graham DB, Sundberg TB, Latorre I, Mikkelsen TS, Xavier RJ. Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing. Cell Syst. 2016 05 25; 2(5):323-334. PMID: 27211859.
    Citations: 12     Fields:    Translation:Cells
  42. Graham DB, Root DE. Resources for the design of CRISPR gene editing experiments. Genome Biol. 2015 Nov 27; 16:260. PMID: 26612492; PMCID: PMC4661947.
    Citations: 42     Fields:    Translation:Cells
  43. Graham DB, Becker CE, Doan A, Goel G, Villablanca EJ, Knights D, Mok A, Ng ACY, Doench JG, Root DE, Clish CB, Xavier RJ. Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst. Nat Commun. 2015 Jul 21; 6:7838. PMID: 26194095.
    Citations: 15     Fields:    Translation:AnimalsCells
  44. Bachman JC, Kavian R, Graham DJ, Kim DY, Noda S, Nocera DG, Shao-Horn Y, Lee SW. Electrochemical polymerization of pyrene derivatives on functionalized carbon nanotubes for pseudocapacitive electrodes. Nat Commun. 2015 May 06; 6:7040. PMID: 25943905; PMCID: PMC4432658.
    Citations: 9     Fields:    
  45. Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell. 2014 Oct 09; 159(2):440-55. PMID: 25263330.
    Citations: 689     Fields:    Translation:AnimalsCells
  46. Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier RJ, Root DE. Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation. Nat Biotechnol. 2014 Dec; 32(12):1262-7. PMID: 25184501.
    Citations: 609     Fields:    Translation:HumansAnimalsCells
  47. Sundberg TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B, Gagnon J, O'Connell DJ, Narayan K, Dancík V, Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, Shamji AF. Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34):12468-73. PMID: 25114223; PMCID: PMC4151730.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  48. Graham DJ, Zheng SL, Nocera DG. Post-synthetic modification of hangman porphyrins synthesized on the gram scale. ChemSusChem. 2014 Sep; 7(9):2449-52. PMID: 24975130.
    Citations:    Fields:    Translation:Cells
  49. Graham DB, Osborne DG, Piotrowski JT, Gomez TS, Gmyrek GB, Akilesh HM, Dani A, Billadeau DD, Swat W. Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming. PLoS One. 2014; 9(6):e98606. PMID: 24886983.
    Citations: 7     Fields:    Translation:AnimalsCells
  50. Ullman AM, Sun X, Graham DJ, Lopez N, Nava M, De Las Cuevas R, Müller P, Rybak-Akimova EV, Cummins CC, Nocera DG. Electron-transfer studies of a peroxide dianion. Inorg Chem. 2014 May 19; 53(10):5384-91. PMID: 24773522.
    Citations:    Fields:    Translation:Cells
  51. Graham DL, Gray AJ, Joyce JA, Yu D, O'Moore J, Carlson GA, Shearman MS, Dellovade TL, Hering H. Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy. Neuropharmacology. 2014 Apr; 79:307-13. PMID: 24326295.
    Citations: 32     Fields:    Translation:AnimalsCells
  52. Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ. Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules. ACS Chem Biol. 2013 Dec 20; 8(12):2724-2733. PMID: 24168452.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  53. Gmyrek GB, Akilesh HM, Graham DB, Fuchs A, Yang L, Miller MJ, Sandoval GJ, Sheehan KC, Schreiber RD, Diamond MS, Swat W. Loss of DAP12 and FcR? drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs. PLoS One. 2013; 8(10):e76145. PMID: 24155889.
    Citations: 5     Fields:    Translation:AnimalsCells
  54. Sandoval GJ, Graham DB, Gmyrek GB, Akilesh HM, Fujikawa K, Sammut B, Bhattacharya D, Srivatsan S, Kim A, Shaw AS, Yang-Iott K, Bassing CH, Duncavage E, Xavier RJ, Swat W. Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL. Cancer Immunol Res. 2013 Dec; 1(6):426-37. PMID: 24778134.
    Citations: 10     Fields:    Translation:AnimalsCells
  55. Graham DB, Xavier RJ. From genetics of inflammatory bowel disease towards mechanistic insights. Trends Immunol. 2013 Aug; 34(8):371-8. PMID: 23639549.
    Citations: 33     Fields:    Translation:Humans
  56. Gmyrek GB, Graham DB, Sandoval GJ, Blaufuss GS, Akilesh HM, Fujikawa K, Xavier RJ, Swat W. Polarity gene discs large homolog 1 regulates the generation of memory T cells. Eur J Immunol. 2013 May; 43(5):1185-94. PMID: 23436244.
    Citations: 11     Fields:    Translation:AnimalsCells
  57. Sandoval GJ, Graham DB, Bhattacharya D, Sleckman BP, Xavier RJ, Swat W. Cutting edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells. J Immunol. 2013 Mar 15; 190(6):2485-9. PMID: 23420891; PMCID: PMC3649847.
    Citations: 6     Fields:    Translation:AnimalsCells
  58. Cremasco V, Decker CE, Stumpo D, Blackshear PJ, Nakayama KI, Nakayama K, Lupu TS, Graham DB, Novack DV, Faccio R. Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts. J Bone Miner Res. 2012 Dec; 27(12):2452-63. PMID: 22806935.
    Citations: 27     Fields:    Translation:AnimalsCells
  59. Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 2012 Aug 24; 37(2):276-89. PMID: 22884313.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  60. Graham DJ, Dogutan DK, Schwalbe M, Nocera DG. Hangman effect on hydrogen peroxide dismutation by Fe(III) corroles. Chem Commun (Camb). 2012 May 04; 48(35):4175-7. PMID: 22441241.
    Citations: 2     Fields:    
  61. Lopez N, Graham DJ, McGuire R, Alliger GE, Shao-Horn Y, Cummins CC, Nocera DG. Reversible reduction of oxygen to peroxide facilitated by molecular recognition. Science. 2012 Jan 27; 335(6067):450-3. PMID: 22282808.
    Citations: 9     Fields:    
  62. Graham DB, Akilesh HM, Gmyrek GB, Piccio L, Gilfillan S, Sim J, Belizaire R, Carrero JA, Wang Y, Blaufuss GS, Sandoval G, Fujikawa K, Cross AH, Russell JH, Cella M, Swat W. ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling. Blood. 2010 Oct 28; 116(17):3208-18. PMID: 20634378; PMCID: PMC2995352.
    Citations: 11     Fields:    Translation:AnimalsCells
  63. Miletic AV, Graham DB, Sakata-Sogawa K, Hiroshima M, Hamann MJ, Cemerski S, Kloeppel T, Billadeau DD, Kanagawa O, Tokunaga M, Swat W. Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity. PLoS One. 2009 Aug 12; 4(8):e6599. PMID: 19672294.
    Citations: 34     Fields:    Translation:AnimalsCells
  64. Stephenson LM, Miller BC, Ng A, Eisenberg J, Zhao Z, Cadwell K, Graham DB, Mizushima NN, Xavier R, Virgin HW, Swat W. Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy. 2009 Jul; 5(5):625-35. PMID: 19276668.
    Citations: 95     Fields:    Translation:AnimalsCells
  65. Graham DB, Zinselmeyer BH, Mascarenhas F, Delgado R, Miller MJ, Swat W. ITAM signaling by Vav family Rho guanine nucleotide exchange factors regulates interstitial transit rates of neutrophils in vivo. PLoS One. 2009; 4(2):e4652. PMID: 19247495.
    Citations: 17     Fields:    Translation:AnimalsCells
  66. Cremasco V, Graham DB, Novack DV, Swat W, Faccio R. Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis. Arthritis Rheum. 2008 Sep; 58(9):2712-22. PMID: 18759305; PMCID: PMC3004987.
    Citations: 21     Fields:    Translation:AnimalsCells
  67. Graham DB, Stephenson LM, Lam SK, Brim K, Lee HM, Bautista J, Gilfillan S, Akilesh S, Fujikawa K, Swat W. An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells. J Exp Med. 2007 Nov 26; 204(12):2889-97. PMID: 17984307.
    Citations: 31     Fields:    Translation:HumansCells
  68. Graham DB, Robertson CM, Bautista J, Mascarenhas F, Diacovo MJ, Montgrain V, Lam SK, Cremasco V, Dunne WM, Faccio R, Coopersmith CM, Swat W. Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice. J Clin Invest. 2007 Nov; 117(11):3445-52. PMID: 17932569; PMCID: PMC2000813.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  69. Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, Laplant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, Tamminga CA, Cooper DC, Gershenfeld HK, Nestler EJ. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell. 2007 Oct 19; 131(2):391-404. PMID: 17956738.
    Citations: 901     Fields:    Translation:HumansAnimalsCells
  70. Stephenson LM, Sammut B, Graham DB, Chan-Wang J, Brim KL, Huett AS, Miletic AV, Kloeppel T, Landry A, Xavier R, Swat W. DLGH1 is a negative regulator of T-lymphocyte proliferation. Mol Cell Biol. 2007 Nov; 27(21):7574-81. PMID: 17724087; PMCID: PMC2169038.
    Citations: 21     Fields:    Translation:AnimalsCells
  71. Graham DL, Edwards S, Bachtell RK, DiLeone RJ, Rios M, Self DW. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat Neurosci. 2007 Aug; 10(8):1029-37. PMID: 17618281.
    Citations: 213     Fields:    Translation:AnimalsCells
  72. Miletic AV, Graham DB, Montgrain V, Fujikawa K, Kloeppel T, Brim K, Weaver B, Schreiber R, Xavier R, Swat W. Vav proteins control MyD88-dependent oxidative burst. Blood. 2007 Apr 15; 109(8):3360-8. PMID: 17158234; PMCID: PMC1852252.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  73. Graham DB, Bell MP, Huntoon CJ, Griffin MD, Tai X, Singer A, McKean DJ. CD28 ligation costimulates cell death but not maturation of double-positive thymocytes due to defective ERK MAPK signaling. J Immunol. 2006 Nov 01; 177(9):6098-107. PMID: 17056536.
    Citations: 9     Fields:    Translation:AnimalsCells
  74. Graham DB, Cella M, Giurisato E, Fujikawa K, Miletic AV, Kloeppel T, Brim K, Takai T, Shaw AS, Colonna M, Swat W. Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics. J Immunol. 2006 Aug 15; 177(4):2349-55. PMID: 16887996.
    Citations: 48     Fields:    Translation:AnimalsCells
  75. Graham DB, Bell MP, McCausland MM, Huntoon CJ, van Deursen J, Faubion WA, Crotty S, McKean DJ. Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice. J Immunol. 2006 Jan 01; 176(1):291-300. PMID: 16365421.
    Citations: 39     Fields:    Translation:AnimalsCells
  76. Graham DB, Bell MP, Huntoon CJ, Weaver JG, Hawley N, Badley AD, McKean DJ. Increased thymic output in HIV-negative patients after antiretroviral therapy. AIDS. 2005 Sep 23; 19(14):1467-72. PMID: 16135899.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  77. Bell MP, Huntoon CJ, Graham D, McKean DJ. The analysis of costimulatory receptor signaling cascades in normal T lymphocytes using in vitro gene transfer and reporter gene analysis. Nat Med. 2001 Oct; 7(10):1155-8. PMID: 11590441.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.