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Steven James Mentzer, M.D.

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Mentoring
current student opportunities
Unpaid research trainee [login at prompt]
Available: 06/27/24, Expires: 06/30/26

A focus of our laboratory is the adaptive and regenerative processes contributing to tissue repair and regeneration. These processes typically involve blood vessel growth (angiogenesis) and changes in the organ surface (mesothelial-mesenchymal transition). The study of these processes involves a multi-scale approach: 1) the regulated expression of genes and molecules, 2) the interactive signaling communication between cells, and 3) the structural/biomechanical relationships leading to adult tissue remodeling (morphogenesis). A recent focus of our approach has been the use of biologic polymers(such as pectin) as tools to explore mesothelial-mesenchymal transition and other fundamental processes essential to normal tissue repair and regeneration. The perturbation of these processes is a major contributor to lung disease and lung cancer.


Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R56HL136476 (MENTZER, STEVEN) Sep 25, 2018 - Aug 31, 2020
    NIH
    Manipulating Tissue Strain in Surgical Repair
    Role: Principal Investigator
  2. R01HL094567 (MENTZER, STEVEN) Dec 1, 2008 - May 31, 2019
    NIH
    Adult Tissue Morphogenesis: Functional Regulation of Intussusceptive Angiogenesis
    Role: Principal Investigator
  3. R01HL075426 (MENTZER, STEVEN J) Sep 26, 2003 - Aug 31, 2009
    NIH
    Physiology of Systemic and Pulmonary Microangiectasias
    Role: Principal Investigator
  4. R01HL047078 (MENTZER, STEVEN J) Jul 2, 1992 - Mar 31, 2009
    NIH
    Microangiectasia Regulation of Lymphocyte Migration
    Role: Principal Investigator
  5. R29HL047078 (MENTZER, STEVEN J) Jul 2, 1992 - Jun 30, 1997
    NIH
    LYMPHOCYTE RECRUITMENT IN LUNG TRANSPLATATION
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 272 total Publications Show all
  1. Saravanan T, Pan JM, Zingl FG, Waldor MK, Zheng Y, Khalil HA, Mentzer SJ. Pectin Hydrogels as Structural Platform for Antibacterial Drug Delivery. Polymers (Basel). 2024 Nov 19; 16(22). PMID: 39599293; PMCID: PMC11598490.
    Citations:
  2. Sutlive J, Liu BS, Kwan SA, Pan JM, Gou K, Xu R, Ali AB, Khalil HA, Ackermann M, Chen Z, Mentzer SJ. Buckling forces and the wavy folds between pleural epithelial cells. Biosystems. 2024 Jun; 240:105216. PMID: 38692427; PMCID: PMC11139554.
    Citations: 1
    Fields: BioBiologyComComputational BiologyTranslation:HumansAnimalsCells
  3. Ackermann M, Werlein C, Plucinski E, Leypold S, Kühnel MP, Verleden SE, Khalil HA, Länger F, Welte T, Mentzer SJ, Jonigk DD. The role of vasculature and angiogenesis in respiratory diseases. Angiogenesis. 2024 Aug; 27(3):293-310. PMID: 38580869; PMCID: PMC11303512.
    Citations: 5
    Fields: HemHematologyTranslation:HumansAnimals
  4. Liu BS, Ali AB, Kwan SP, Pan JM, Wagner WL, Khalil HA, Chen Z, Ackermann M, Mentzer SJ. Evolving topological order in the postnatal visceral pleura. Dev Dyn. 2024 Aug; 253(8):711-721. PMID: 38169311; PMCID: PMC11219525.
    Citations:
    Fields: AnaAnatomyTranslation:AnimalsCells
  5. Dayal A, Pan JM, Kwan SP, Ackermann M, Khalil HA, Mentzer SJ. Facilitated Transport across Glycocalyceal Barriers in the Chick Chorioallantoic Membrane. Polymers (Basel). 2023 Dec 19; 16(1). PMID: 38201668; PMCID: PMC10781099.
    Citations: 1
  6. Chamoto K, Gibney BC, Wagner WL, Ackermann M, Khalil HA, Mentzer SJ. Vascularization of the adult mouse lung grafted onto the chick chorioallantoic membrane. Microvasc Res. 2024 01; 151:104596. PMID: 37625620.
    Citations: 1
    Fields: VasVascular DiseasesTranslation:Animals
  7. Fan X, Valenzuela C, Zhao W, Chen Z, Wang D, Mentzer SJ. Stochastic simulations of self-organized elastogenesis in the developing lung. PLoS Comput Biol. 2023 06; 19(6):e1011219. PMID: 37315061; PMCID: PMC10298752.
    Citations:
    Fields: ComComputational BiologyTranslation:AnimalsCells
  8. Liu BS, Sutlive J, Wagner WL, Khalil HA, Chen Z, Ackermann M, Mentzer SJ. Geometric and network organization of visceral organ epithelium. Front Netw Physiol. 2023; 3:1144186. PMID: 37234691; PMCID: PMC10208427.
    Citations: 1
  9. Liu BS, Liao M, Wagner WL, Khalil HA, Chen Z, Ackermann M, Mentzer SJ. Biomechanics of a Plant-Derived Sealant for Corneal Injuries. Transl Vis Sci Technol. 2023 05 01; 12(5):20. PMID: 37204800; PMCID: PMC10204774.
    Citations:
    Fields: BioBiomedical EngineeringOphOphthalmologyTranslation:AnimalsCells
  10. Williams J, Prey B, Francis A, Weykamp M, Liu B, Parsons M, Vu M, Franko J, Roedel E, Horton J, Bingham J, Mentzer S, Kuckelman J. Bioadhesive patch as a parenchymal sparing treatment of acute traumatic pulmonary air leaks. J Trauma Acute Care Surg. 2023 11 01; 95(5):679-684. PMID: 36973876.
    Citations:
    Fields: GenGeneral SurgeryTraTraumatologyTranslation:HumansAnimals
  11. Floess M, Steinle T, Werner F, Wang Y, Wagner WL, Steinle V, Liu BS, Zheng Y, Chen Z, Ackermann M, Mentzer SJ, Giessen H. 3D stimulated Raman spectral imaging of water dynamics associated with pectin-glycocalyceal entanglement. Biomed Opt Express. 2023 Apr 01; 14(4):1460-1471. PMID: 37078053; PMCID: PMC10110326.
    Citations: 2
  12. Williams J, Prey B, Francis A, Weykamp M, Liu B, Parsons M, Vu M, Franko J, Roedel E, Lallemand M, Bingham J, Mentzer S, Kuckelman J. Pectin based biologic Velcro effectively seals traumatic solid organ and small bowel injuries. J Trauma Acute Care Surg. 2023 07 01; 95(1):55-61. PMID: 36872522; PMCID: PMC11583053.
    Citations:
    Fields: GenGeneral SurgeryTraTraumatologyTranslation:Animals
  13. Vesvoranan O, Liu BS, Zheng Y, Wagner WL, Sutlive J, Chen Z, Khalil HA, Ackermann M, Mentzer SJ. Active Loading of Pectin Hydrogels for Targeted Drug Delivery. Polymers (Basel). 2022 Dec 26; 15(1). PMID: 36616442; PMCID: PMC9824191.
    Citations: 5
  14. Liu BS, Valenzuela CD, Mentzer KL, Wagner WL, Khalil HA, Chen Z, Ackermann M, Mentzer SJ. Topography of pleural epithelial structure enabled by en face isolation and machine learning. J Cell Physiol. 2023 01; 238(1):274-284. PMID: 36502471; PMCID: PMC9845181.
    Citations: 4
    Fields: CelCell BiologyPhyPhysiologyTranslation:AnimalsCells
  15. Werlein C, Ackermann M, Stark H, Shah HR, Tzankov A, Haslbauer JD, von Stillfried S, Bülow RD, El-Armouche A, Kuenzel S, Robertus JL, Reichardt M, Haverich A, Höfer A, Neubert L, Plucinski E, Braubach P, Verleden S, Salditt T, Marx N, Welte T, Bauersachs J, Kreipe HH, Mentzer SJ, Boor P, Black SM, Länger F, Kuehnel M, Jonigk D. Inflammation and vascular remodeling in COVID-19 hearts. Angiogenesis. 2023 05; 26(2):233-248. PMID: 36371548; PMCID: PMC9660162.
    Citations: 16
    Fields: HemHematologyTranslation:HumansCells
  16. Ackermann M, Kamp JC, Werlein C, Walsh CL, Stark H, Prade V, Surabattula R, Wagner WL, Disney C, Bodey AJ, Illig T, Leeming DJ, Karsdal MA, Tzankov A, Boor P, Kühnel MP, Länger FP, Verleden SE, Kvasnicka HM, Kreipe HH, Haverich A, Black SM, Walch A, Tafforeau P, Lee PD, Hoeper MM, Welte T, Seeliger B, David S, Schuppan D, Mentzer SJ, Jonigk DD. The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling. EBioMedicine. 2022 Nov; 85:104296. PMID: 36206625; PMCID: PMC9535314.
    Citations: 18
    Fields: GenGenetics, MedicalMedMedicine (General)Translation:Humans
  17. Mentzer SJ, Ackermann M, Jonigk D. Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19. Cold Spring Harb Perspect Med. 2022 10 03; 12(10). PMID: 35534210; PMCID: PMC9524390.
    Citations: 9
    Fields: MedMedicine (General)Translation:HumansCells
  18. Liao MW, Liu BS, Sutlive J, Wagner WL, Khalil HA, Chen Z, Ackermann M, Mentzer SJ. Kinetics of Pectin Biopolymer Facial Erosion Characterized by Fluorescent Tracer Microfluidics. Polymers (Basel). 2022 Sep 19; 14(18). PMID: 36146055; PMCID: PMC9501333.
    Citations: 3
  19. Ackermann M, Mentzer SJ, Jonigk DD. Reply to Bush et al. and to Persson. Am J Respir Crit Care Med. 2022 07 15; 206(2):229-230. PMID: 35533391; PMCID: PMC9887410.
    Citations:
    Fields: CriCritical CarePulPulmonary MedicineTranslation:HumansCells
  20. Pierce AF, Liu BS, Liao M, Wagner WL, Khalil HA, Chen Z, Ackermann M, Mentzer SJ. Optical and Mechanical Properties of Self-Repairing Pectin Biopolymers. Polymers (Basel). 2022 Mar 26; 14(7). PMID: 35406219; PMCID: PMC9002866.
    Citations: 3
  21. Laenger FP, Schwerk N, Dingemann J, Welte T, Auber B, Verleden S, Ackermann M, Mentzer SJ, Griese M, Jonigk D. Interstitial lung disease in infancy and early childhood: a clinicopathological primer. Eur Respir Rev. 2022 Mar 31; 31(163). PMID: 35264412; PMCID: PMC9488843.
    Citations: 11
    Fields: PulPulmonary MedicineTranslation:Humans
  22. Ackermann M, Tafforeau P, Wagner WL, Walsh CL, Werlein C, Kühnel MP, Länger FP, Disney C, Bodey AJ, Bellier A, Verleden SE, Lee PD, Mentzer SJ, Jonigk DD. The Bronchial Circulation in COVID-19 Pneumonia. Am J Respir Crit Care Med. 2022 01 01; 205(1):121-125. PMID: 34734553; PMCID: PMC8865596.
    Citations: 28
    Fields: CriCritical CarePulPulmonary MedicineTranslation:HumansCells
  23. Shen J, Sheline C, Powell SD, Franz E, Torres LA, Chaney C, Hom G, Mentzer SJ, Hanumara NC. Noninvasive Method and Metric for Monitoring Lung Condition. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:6841-6844. PMID: 34892678.
    Citations:
    Fields: BioBiomedical EngineeringTranslation:Humans
  24. Zheng Y, Pierce AF, Wagner WL, Khalil HA, Chen Z, Servais AB, Ackermann M, Mentzer SJ. Functional Adhesion of Pectin Biopolymers to the Lung Visceral Pleura. Polymers (Basel). 2021 Sep 02; 13(17). PMID: 34503016; PMCID: PMC8433721.
    Citations: 11
  25. Zheng Y, Pierce AF, Wagner WL, Khalil HA, Chen Z, Funaya C, Ackermann M, Mentzer SJ. Biomaterial-Assisted Anastomotic Healing: Serosal Adhesion of Pectin Films. Polymers (Basel). 2021 Aug 21; 13(16). PMID: 34451349; PMCID: PMC8401717.
    Citations: 11
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.