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Qing Yu, Ph.D., M.D.

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Overview
The interests of my laboratory in the Department of Immunology and Infectious Diseases at the Forsyth Institute are to understand the control mechanisms and in vivo function of effector T cells in the pathogenesis of several autoimmune diseases, in order to develop effective and targeted therapeutic approaches for these diseases. One particular interest is the control T cell autoimmune responses by cytokines during the pathogenesis and chronic persistence of Sjogren’s syndrome. Sjogren’s syndrome (SS) is a prevalent chronic autoimmune disease characterized by chronic inflammation and dysfunction of exocrine glands. SS patients suffer from dry mouth, dry eyes and systemic inflammation that can be debilitating and severely compromise the physical and mental health of the patients. Auto-reactive effector T cells of various types collaboratively mediate and orchestrate the autoimmune processes that cause the onset and persistence of SS, and the effects of these auto-reactive T cells are crucially mediated or controlled by a panel of cytokines. By using both mouse models and human samples and combining in vivo and in vitro approaches, we will investigate the regulation of T cell function by cytokines and their role in the pathogenesis and chronic persistence of SS, and develop strategies that target these pathogenic players to ameliorate or reverse this disease. Other interests of our lab include the molecular control of T cell function in the pathogenesis of inflammatory bowel disease, and the anti-inflammatory and immune-regulatory function of IL-6. Our research will provide critical foundations for the development of effective novel therapies to treat various autoimmune diseases.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03AI142273 (YU, QING) Jun 11, 2019 - May 31, 2021
    NIH/NIAID
    Role of Interleukin-22 in the Salivary Gland Disorder in Autoimmune Sjögren's Syndrome
    Role: Principal Investigator
  2. R01DE023838 (YU, QING) Apr 10, 2014 - Jan 31, 2019
    NIH/NIDCR
    Regulation and Function of Interleukin-7 in Primary Sjogrens Syndrome
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhang W, Du JY, Jiang Z, Okimura T, Oda T, Yu Q, Jin JO. Ascophyllan purified from Ascophyllum nodosum induces Th1 and Tc1 immune responses by promoting dendritic cell maturation. Mar Drugs. 2014 Jul 14; 12(7):4148-64. PMID: 25026264.
    Citations: 6     Fields:    Translation:AnimalsCells
  2. Jin JO, Zhang W, Du JY, Wong KW, Oda T, Yu Q. Fucoidan can function as an adjuvant in vivo to enhance dendritic cell maturation and function and promote antigen-specific T cell immune responses. PLoS One. 2014; 9(6):e99396. PMID: 24911024.
    Citations: 16     Fields:    Translation:AnimalsCells
  3. Jin JO, Shinohara Y, Yu Q. Innate immune signaling induces interleukin-7 production from salivary gland cells and accelerates the development of primary Sjögren's syndrome in a mouse model. PLoS One. 2013; 8(10):e77605. PMID: 24147035.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  4. Jin JO, Kawai T, Cha S, Yu Q. Interleukin-7 enhances the Th1 response to promote the development of Sjögren's syndrome-like autoimmune exocrinopathy in mice. Arthritis Rheum. 2013 Aug; 65(8):2132-42. PMID: 23666710.
    Citations: 14     Fields:    Translation:AnimalsCells
  5. Jin JO, Yu Q. T Cell-Associated Cytokines in the Pathogenesis of Sjögren's Syndrome. J Clin Cell Immunol. 2013 Feb 26; S!(9). PMID: 23814683.
    Citations: 6     
  6. Jin JO, Yu Q. Systemic administration of TLR3 agonist induces IL-7 expression and IL-7-dependent CXCR3 ligand production in the lung. J Leukoc Biol. 2013 Mar; 93(3):413-25. PMID: 23271706.
    Citations: 6     Fields:    Translation:AnimalsCells
  7. Jin JO, Han X, Yu Q. Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation. J Autoimmun. 2013 Feb; 40:28-44. PMID: 22921334.
    Citations: 23     Fields:    Translation:AnimalsCells
  8. Kajiya M, Ichimonji I, Min C, Zhu T, Jin JO, Yu Q, Almazrooa SA, Cha S, Kawai T. Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation. Mol Pharmacol. 2012 Jul; 82(1):115-24. PMID: 22511543.
    Citations: 8     Fields:    Translation:HumansCells
  9. Sharma A, Chen Q, Nguyen T, Yu Q, Sen JM. T cell factor-1 and ß-catenin control the development of memory-like CD8 thymocytes. J Immunol. 2012 Apr 15; 188(8):3859-68. PMID: 22492686.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  10. Yu Q, Sharma A, Ghosh A, Sen JM. T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitis. J Immunol. 2011 Apr 01; 186(7):3946-52. PMID: 21339363.
    Citations: 29     Fields:    Translation:AnimalsCells
  11. Yu Q, Sharma A, Sen JM. TCF1 and beta-catenin regulate T cell development and function. Immunol Res. 2010 Jul; 47(1-3):45-55. PMID: 20082155.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  12. Yu Q, Sharma A, Oh SY, Moon HG, Hossain MZ, Salay TM, Leeds KE, Du H, Wu B, Waterman ML, Zhu Z, Sen JM. T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol. 2009 Sep; 10(9):992-9. PMID: 19648923.
    Citations: 83     Fields:    Translation:AnimalsCells
  13. Yu Q, Quinn WJ, Salay T, Crowley JE, Cancro MP, Sen JM. Role of beta-catenin in B cell development and function. J Immunol. 2008 Sep 15; 181(6):3777-83. PMID: 18768830.
    Citations: 8     Fields:    Translation:AnimalsCells
  14. Hossain MZ, Yu Q, Xu M, Sen JM. ICAT expression disrupts beta-catenin-TCF interactions and impairs survival of thymocytes and activated mature T cells. Int Immunol. 2008 Jul; 20(7):925-35. PMID: 18511409.
    Citations: 15     Fields:    Translation:AnimalsCells
  15. Xu M, Yu Q, Subrahmanyam R, Difilippantonio MJ, Ried T, Sen JM. Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo. Mol Cell Biol. 2008 Mar; 28(5):1713-23. PMID: 18160717.
    Citations: 34     Fields:    Translation:Animals
  16. Yu Q, Xu M, Sen JM. Beta-catenin expression enhances IL-7 receptor signaling in thymocytes during positive selection. J Immunol. 2007 Jul 01; 179(1):126-31. PMID: 17579030.
    Citations: 10     Fields:    Translation:AnimalsCells
  17. Yu Q, Sen JM. Beta-catenin regulates positive selection of thymocytes but not lineage commitment. J Immunol. 2007 Apr 15; 178(8):5028-34. PMID: 17404285.
    Citations: 16     Fields:    Translation:AnimalsCells
  18. Yu Q, Park JH, Doan LL, Erman B, Feigenbaum L, Singer A. Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection. J Exp Med. 2006 Jan 23; 203(1):165-75. PMID: 16390939.
    Citations: 31     Fields:    Translation:AnimalsCells
  19. Yu Q, Erman B, Park JH, Feigenbaum L, Singer A. IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development. J Exp Med. 2004 Sep 20; 200(6):797-803. PMID: 15365098.
    Citations: 49     Fields:    Translation:AnimalsCells
  20. Park JH, Yu Q, Erman B, Appelbaum JS, Montoya-Durango D, Grimes HL, Singer A. Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity. 2004 Aug; 21(2):289-302. PMID: 15308108.
    Citations: 162     Fields:    Translation:AnimalsCells
  21. Yu Q, Erman B, Bhandoola A, Sharrow SO, Singer A. In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells. J Exp Med. 2003 Feb 17; 197(4):475-87. PMID: 12591905.
    Citations: 40     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.