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Jiaxuan Chen, Ph.D.

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Overview
My research focus is chronic vascular inflammation in the pathogenesis of atherosclerosis, aneurysm, and intimal hyperplasia. I am specifically interested in the role of resolvin, syndecan-1, mitochondria, and aryl hydrocarbon receptor.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chen J, Howell C, Haller CA, Patel MS, Ayala P, Moravec KA, Dai E, Liu L, Sotiri I, Aizenberg M, Aizenberg J, Chaikof EL. An immobilized liquid interface prevents device associated bacterial infection in vivo. Biomaterials. 2017 01; 113:80-92. PMID: 27810644.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  2. Angsana J, Chen J, Liu L, Haller CA, Chaikof EL. Efferocytosis as a regulator of macrophage chemokine receptor expression and polarization. Eur J Immunol. 2016 07; 46(7):1592-9. PMID: 27139187.
    Citations: 4     Fields:    Translation:AnimalsCells
  3. Angsana J, Chen J, Smith S, Xiao J, Wen J, Liu L, Haller CA, Chaikof EL. Syndecan-1 modulates the motility and resolution responses of macrophages. Arterioscler Thromb Vasc Biol. 2015 Feb; 35(2):332-40. PMID: 25550207.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  4. Doroudi M, Chen J, Boyan BD, Schwartz Z. New insights on membrane mediated effects of 1a,25-dihydroxy vitamin D3 signaling in the musculoskeletal system. Steroids. 2014 Mar; 81:81-7. PMID: 24291576.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  5. Chen J, Doroudi M, Cheung J, Grozier AL, Schwartz Z, Boyan BD. Plasma membrane Pdia3 and VDR interact to elicit rapid responses to 1a,25(OH)(2)D(3). Cell Signal. 2013 Dec; 25(12):2362-73. PMID: 23896121.
    Citations: 11     Fields:    Translation:AnimalsCells
  6. Chen J, Dosier CR, Park JH, De S, Guldberg RE, Boyan BD, Schwartz Z. Mineralization of three-dimensional osteoblast cultures is enhanced by the interaction of 1a,25-dihydroxyvitamin D3 and BMP2 via two specific vitamin D receptors. J Tissue Eng Regen Med. 2016 Jan; 10(1):40-51. PMID: 23784946.
    Citations: 5     Fields:    Translation:AnimalsCells
  7. Chen J, Lobachev KS, Grindel BJ, Farach-Carson MC, Hyzy SL, El-Baradie KB, Olivares-Navarrete R, Doroudi M, Boyan BD, Schwartz Z. Chaperone properties of pdia3 participate in rapid membrane actions of 1a,25-dihydroxyvitamin d3. Mol Endocrinol. 2013 Jul; 27(7):1065-77. PMID: 23660595.
    Citations: 4     Fields:    Translation:AnimalsCells
  8. Boyan BD, Chen J, Schwartz Z. Mechanism of Pdia3-dependent 1a,25-dihydroxy vitamin D3 signaling in musculoskeletal cells. Steroids. 2012 Aug; 77(10):892-6. PMID: 22569272.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  9. Chen J, Olivares-Navarrete R, Wang Y, Herman TR, Boyan BD, Schwartz Z. Protein-disulfide isomerase-associated 3 (Pdia3) mediates the membrane response to 1,25-dihydroxyvitamin D3 in osteoblasts. J Biol Chem. 2010 Nov 19; 285(47):37041-50. PMID: 20843786.
    Citations: 20     Fields:    Translation:AnimalsCells
  10. Wang Y, Chen J, Lee CS, Nizkorodov A, Riemenschneider K, Martin D, Hyzy S, Schwartz Z, Boyan BD. Disruption of Pdia3 gene results in bone abnormality and affects 1alpha,25-dihydroxy-vitamin D3-induced rapid activation of PKC. J Steroid Biochem Mol Biol. 2010 Jul; 121(1-2):257-60. PMID: 20576531.
    Citations: 9     Fields:    Translation:AnimalsCells
  11. Zhang S, Zhong N, Xue F, Kang X, Ren X, Chen J, Jin C, Lou Z, Xia B. Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease. Protein Cell. 2010 Apr; 1(4):371-383. PMID: 21203949.
    Citations: 5     Fields:    Translation:HumansCells
  12. Zhong N, Zhang S, Xue F, Kang X, Zou P, Chen J, Liang C, Rao Z, Jin C, Lou Z, Xia B. C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer. Protein Sci. 2009 Apr; 18(4):839-44. PMID: 19319935.
    Citations: 7     Fields:    Translation:HumansCells
  13. Zhong N, Zhang S, Zou P, Chen J, Kang X, Li Z, Liang C, Jin C, Xia B. Without its N-finger, the main protease of severe acute respiratory syndrome coronavirus can form a novel dimer through its C-terminal domain. J Virol. 2008 May; 82(9):4227-34. PMID: 18305043.
    Citations: 6     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.