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Jiaxuan Chen, Ph.D.

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I am interested in mechanism-based target identification and therapeutic development in immune system. Current projects include engineering delivery vehicles for targeted genome editing in vivo, developing small molecule drugs for immune modulation, and designing glycopeptides for the treatment of thrombo-inflammatory diseases.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zeng J, Aryal RP, Stavenhagen K, Luo C, Liu R, Wang X, Chen J, Li H, Matsumoto Y, Wang Y, Wang J, Ju T, Cummings RD. Cosmc deficiency causes spontaneous autoimmunity by breaking B cell tolerance. Sci Adv. 2021 Oct 08; 7(41):eabg9118. PMID: 34613773; PMCID: PMC8494437.
    Citations: 1     Fields:    
  2. Wong DJ, Park DD, Park SS, Haller CA, Chen J, Dai E, Liu L, Mandhapati AR, Eradi P, Dhakal B, Wever WJ, Hanes M, Sun L, Cummings RD, Chaikof EL. A PSGL-1 glycomimetic reduces thrombus burden without affecting hemostasis. Blood. 2021 09 30; 138(13):1182-1193. PMID: 33945603; PMCID: PMC8570056.
    Citations: 1     Fields:    Translation:HumansAnimals
  3. Varghese M, Rokosh RS, Haller CA, Chin SL, Chen J, Dai E, Xiao R, Chaikof EL, Grinstaff MW. Sulfated poly-amido-saccharides (sulPASs) are anticoagulants in vitro and in vivo. Chem Sci. 2021 Oct 06; 12(38):12719-12725. PMID: 34703558; PMCID: PMC8494039.
    Citations: 1     
  4. Park DD, Chen J, Kudelka MR, Jia N, Haller CA, Kosaraju R, Premji AM, Galizzi M, Nairn AV, Moremen KW, Cummings RD, Chaikof EL. Resident and elicited murine macrophages differ in expression of their glycomes and glycan-binding proteins. Cell Chem Biol. 2021 04 15; 28(4):567-582.e4. PMID: 33378651; PMCID: PMC8052306.
    Citations: 2     Fields:    Translation:AnimalsCells
  5. Chen J, Haller CA, Jernigan FE, Koerner SK, Wong DJ, Wang Y, Cheong JE, Kosaraju R, Kwan J, Park DD, Thomas B, Bhasin S, De La Rosa RC, Premji AM, Liu L, Park E, Moss AC, Emili A, Bhasin M, Sun L, Chaikof EL. Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists. Sci Adv. 2020 01; 6(3):eaay8230. PMID: 31998845.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  6. Patel MS, Miranda-Nieves D, Chen J, Haller CA, Chaikof EL. Targeting P-selectin glycoprotein ligand-1/P-selectin interactions as a novel therapy for metabolic syndrome. Transl Res. 2017 05; 183:1-13. PMID: 28034759; PMCID: PMC5393932.
    Citations: 11     Fields:    Translation:Humans
  7. Chen J, Haller CA, Chaikof EL. Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1. Transl Cancer Res. 2016 Oct; 5(Suppl 4):S668-S671. PMID: 30613475; PMCID: PMC6319942.
    Citations: 1     
  8. Chen J, Howell C, Haller CA, Patel MS, Ayala P, Moravec KA, Dai E, Liu L, Sotiri I, Aizenberg M, Aizenberg J, Chaikof EL. An immobilized liquid interface prevents device associated bacterial infection in vivo. Biomaterials. 2017 01; 113:80-92. PMID: 27810644.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  9. Angsana J, Chen J, Liu L, Haller CA, Chaikof EL. Efferocytosis as a regulator of macrophage chemokine receptor expression and polarization. Eur J Immunol. 2016 07; 46(7):1592-9. PMID: 27139187; PMCID: PMC5036921.
    Citations: 15     Fields:    Translation:AnimalsCells
  10. Angsana J, Chen J, Smith S, Xiao J, Wen J, Liu L, Haller CA, Chaikof EL. Syndecan-1 modulates the motility and resolution responses of macrophages. Arterioscler Thromb Vasc Biol. 2015 Feb; 35(2):332-40. PMID: 25550207; PMCID: PMC4304980.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  11. Doroudi M, Chen J, Boyan BD, Schwartz Z. New insights on membrane mediated effects of 1a,25-dihydroxy vitamin D3 signaling in the musculoskeletal system. Steroids. 2014 Mar; 81:81-7. PMID: 24291576.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  12. Chen J, Doroudi M, Cheung J, Grozier AL, Schwartz Z, Boyan BD. Plasma membrane Pdia3 and VDR interact to elicit rapid responses to 1a,25(OH)(2)D(3). Cell Signal. 2013 Dec; 25(12):2362-73. PMID: 23896121.
    Citations: 28     Fields:    Translation:AnimalsCells
  13. Chen J, Dosier CR, Park JH, De S, Guldberg RE, Boyan BD, Schwartz Z. Mineralization of three-dimensional osteoblast cultures is enhanced by the interaction of 1a,25-dihydroxyvitamin D3 and BMP2 via two specific vitamin D receptors. J Tissue Eng Regen Med. 2016 Jan; 10(1):40-51. PMID: 23784946.
    Citations: 13     Fields:    Translation:AnimalsCells
  14. Chen J, Lobachev KS, Grindel BJ, Farach-Carson MC, Hyzy SL, El-Baradie KB, Olivares-Navarrete R, Doroudi M, Boyan BD, Schwartz Z. Chaperone properties of pdia3 participate in rapid membrane actions of 1a,25-dihydroxyvitamin d3. Mol Endocrinol. 2013 Jul; 27(7):1065-77. PMID: 23660595.
    Citations: 7     Fields:    Translation:AnimalsCells
  15. Boyan BD, Chen J, Schwartz Z. Mechanism of Pdia3-dependent 1a,25-dihydroxy vitamin D3 signaling in musculoskeletal cells. Steroids. 2012 Aug; 77(10):892-6. PMID: 22569272.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  16. Chen J, Olivares-Navarrete R, Wang Y, Herman TR, Boyan BD, Schwartz Z. Protein-disulfide isomerase-associated 3 (Pdia3) mediates the membrane response to 1,25-dihydroxyvitamin D3 in osteoblasts. J Biol Chem. 2010 Nov 19; 285(47):37041-50. PMID: 20843786; PMCID: PMC2978632.
    Citations: 33     Fields:    Translation:AnimalsCells
  17. Wang Y, Chen J, Lee CS, Nizkorodov A, Riemenschneider K, Martin D, Hyzy S, Schwartz Z, Boyan BD. Disruption of Pdia3 gene results in bone abnormality and affects 1alpha,25-dihydroxy-vitamin D3-induced rapid activation of PKC. J Steroid Biochem Mol Biol. 2010 Jul; 121(1-2):257-60. PMID: 20576531.
    Citations: 13     Fields:    Translation:AnimalsCells
  18. Zhang S, Zhong N, Xue F, Kang X, Ren X, Chen J, Jin C, Lou Z, Xia B. Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease. Protein Cell. 2010 Apr; 1(4):371-383. PMID: 21203949.
    Citations: 22     Fields:    Translation:HumansCells
  19. Zhong N, Zhang S, Xue F, Kang X, Zou P, Chen J, Liang C, Rao Z, Jin C, Lou Z, Xia B. C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer. Protein Sci. 2009 Apr; 18(4):839-44. PMID: 19319935.
    Citations: 15     Fields:    Translation:HumansCells
  20. Zhong N, Zhang S, Zou P, Chen J, Kang X, Li Z, Liang C, Jin C, Xia B. Without its N-finger, the main protease of severe acute respiratory syndrome coronavirus can form a novel dimer through its C-terminal domain. J Virol. 2008 May; 82(9):4227-34. PMID: 18305043.
    Citations: 32     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.