Harvard Catalyst Profiles

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Zhongjie Fu, Ph.D.


The Bernadotte Foundation Travel Award
Knights Templar Eye Foundation Pediatric Ophthalmology Career-starter Research Award
Knights Templar Eye Foundation Pediatric Ophthalmology Competitive Renewal Research Award
Asia-ARVO 2017 Travel Grant
Seahorse Bioscience Travel Award
The Blind Children’s Center (BCC) One-year Seed Grant
Boston Children's Hospital The Manton Center Fellowship
AOPT Travel Award
Boston Children's Hospital OFD/BTREC/CTREC Career Development Fellowships
The Little Giraffe Foundation Neonatal Research Grant
Boston Children's Hospital Pilot Award
Massachusetts Lions Eye Research Fund
AOPT BrightFocus Foundation Excellence Paper Award
Massachusetts Lions Eye Research Fund

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY032492 (FU, ZHONGJIE) May 1, 2021 - Mar 31, 2026
    Serine control of retinal neovascularization in retinopathy
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Leinonen HO, Bull E, Fu Z. Neural and Müller glial adaptation of the retina to photoreceptor degeneration. Neural Regen Res. 2023 Apr; 18(4):701-707. PMID: 36204825; PMCID: PMC9700092.
  2. Wang Z, Yemanyi F, Blomfield AK, Bora K, Huang S, Liu CH, Britton WR, Cho SS, Tomita Y, Fu Z, Ma JX, Li WH, Chen J. Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis. Elife. 2022 12 01; 11. PMID: 36454214; PMCID: PMC9714971.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Fu Z, Nilsson AK, Hellstrom A, Smith LEH. Retinopathy of prematurity: Metabolic risk factors. Elife. 2022 11 24; 11. PMID: 36420952; PMCID: PMC9691009.
    Citations:    Fields:    Translation:HumansAnimals
  4. Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock CE, Singh SA, Aikawa M, Smith LE, Proia RL, Hla T. Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis. Elife. 2022 Oct 05; 11. PMID: 36197001; PMCID: PMC9578713.
    Citations:    Fields:    Translation:AnimalsCells
  5. Chen CT, Shao Z, Fu Z. Dysfunctional peroxisomal lipid metabolisms and their ocular manifestations. Front Cell Dev Biol. 2022; 10:982564. PMID: 36187472; PMCID: PMC9524157.
    Citations: 1     
  6. Liu J, Tsang JKW, Fung FKC, Chung SK, Fu Z, Lo ACY. Retinal microglia protect against vascular damage in a mouse model of retinopathy of prematurity. Front Pharmacol. 2022; 13:945130. PMID: 36059936; PMCID: PMC9431881.
    Citations: 1     
  7. Gong Y, Tomita Y, Edin ML, Ren A, Ko M, Yang J, Bull E, Zeldin DC, Hellström A, Fu Z, Smith LEH. Cytochrome P450 oxidase 2J inhibition suppresses choroidal neovascularization in mice. Metabolism. 2022 09; 134:155266. PMID: 35868524; PMCID: PMC9535696.
    Citations:    Fields:    
  8. Fu Z, Yan W, Chen CT, Nilsson AK, Bull E, Allen W, Yang J, Ko M, SanGiovanni JP, Akula JD, Talukdar S, Hellström A, Smith LEH. Omega-3/Omega-6 Long-Chain Fatty Acid Imbalance in Phase I Retinopathy of Prematurity. Nutrients. 2022 Mar 23; 14(7). PMID: 35405946; PMCID: PMC9002570.
    Citations:    Fields:    Translation:HumansAnimals
  9. Huang S, Liu CH, Wang Z, Fu Z, Britton WR, Blomfield AK, Kamenecka TM, Dunaief JL, Solt LA, Chen J. REV-ERBa regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2. Redox Biol. 2022 05; 51:102261. PMID: 35176707; PMCID: PMC8851379.
    Citations:    Fields:    Translation:Animals
  10. Fu Z, Usui-Ouchi A, Allen W, Tomita Y. Retinal Disease and Metabolism. Life (Basel). 2022 Jan 27; 12(2). PMID: 35207471; PMCID: PMC8879522.
  11. Tomita Y, Qiu C, Bull E, Allen W, Kotoda Y, Talukdar S, Smith LEH, Fu Z. Müller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa. Exp Mol Med. 2021 11; 53(11):1748-1758. PMID: 34799683; PMCID: PMC8639781.
    Citations: 2     Fields:    Translation:AnimalsCells
  12. Tomita Y, Usui-Ouchi A, Nilsson AK, Yang J, Ko M, Hellström A, Fu Z. Metabolism in Retinopathy of Prematurity. Life (Basel). 2021 Oct 21; 11(11). PMID: 34832995.
    Citations: 3     
  13. Shao Z, Wang Z, Lo ACY, Fu Z. Editorial: Novel Therapeutic Target and Drug Development in Neurovascular Retinal Diseases. Front Pharmacol. 2021; 12:657684. PMID: 33935774.
  14. Fu Z, Smith LEH. Cellular senescence in pathologic retinal angiogenesis. Trends Endocrinol Metab. 2021 07; 32(7):415-416. PMID: 33863618; PMCID: PMC8612461.
    Citations: 1     Fields:    Translation:Animals
  15. Fu Z, Qiu C, Cagnone G, Tomita Y, Huang S, Cakir B, Kotoda Y, Allen W, Bull E, Akula JD, Joyal JS, Hellström A, Talukdar S, Smith LEH. Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration. iScience. 2021 Apr 23; 24(4):102376. PMID: 33937726.
    Citations: 4     
  16. Fu Z, Kern TS, Hellström A, Smith LEH. Fatty acid oxidation and photoreceptor metabolic needs. J Lipid Res. 2021; 62:100035. PMID: 32094231; PMCID: PMC7905050.
    Citations: 17     Fields:    Translation:Cells
  17. Tomita Y, Cagnone G, Fu Z, Cakir B, Kotoda Y, Asakage M, Wakabayashi Y, Hellström A, Joyal JS, Talukdar S, Smith LEH, Usui Y. Vitreous metabolomics profiling of proliferative diabetic retinopathy. Diabetologia. 2021 01; 64(1):70-82. PMID: 33099660.
    Citations: 9     Fields:    Translation:HumansAnimals
  18. Cakir B, Hellström W, Tomita Y, Fu Z, Liegl R, Winberg A, Hansen-Pupp I, Ley D, Hellström A, Löfqvist C, Smith LE. IGF1, serum glucose, and retinopathy of prematurity in extremely preterm infants. JCI Insight. 2020 10 02; 5(19). PMID: 33004691.
    Citations: 3     Fields:    Translation:HumansAnimals
  19. Wang Z, Liu CH, Huang S, Fu Z, Tomita Y, Britton WR, Cho SS, Chen CT, Sun Y, Ma JX, He X, Chen J. Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier. Sci Adv. 2020 08; 6(35):eaba7457. PMID: 32923627; PMCID: PMC7455181.
    Citations: 12     Fields:    
  20. Tomita Y, Shao Z, Cakir B, Kotoda Y, Fu Z, Smith LEH. An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis. J Vis Exp. 2020 08 06; (162). PMID: 32831307.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  21. Li LH, Lee JC, Leung HH, Lam WC, Fu Z, Lo ACY. Lutein Supplementation for Eye Diseases. Nutrients. 2020 Jun 09; 12(6). PMID: 32526861.
    Citations: 14     Fields:    Translation:HumansAnimals
  22. Tomita Y, Cakir B, Liu CH, Fu Z, Huang S, Cho SS, Britton WR, Sun Y, Puder M, Hellström A, Talukdar S, Smith LEH. Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice. Angiogenesis. 2020 08; 23(3):385-394. PMID: 32140799.
    Citations: 12     Fields:    Translation:Animals
  23. Fu Z, Sun Y, Cakir B, Tomita Y, Huang S, Wang Z, Liu CH, S Cho S, Britton W, S Kern T, Antonetti DA, Hellström A, E H Smith L. Targeting Neurovascular Interaction in Retinal Disorders. Int J Mol Sci. 2020 Feb 22; 21(4). PMID: 32098361.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  24. Yanagida K, Engelbrecht E, Niaudet C, Jung B, Gaengel K, Holton K, Swendeman S, Liu CH, Levesque MV, Kuo A, Fu Z, Smith LEH, Betsholtz C, Hla T. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020 03 23; 52(6):779-793.e7. PMID: 32059774.
    Citations: 16     Fields:    Translation:AnimalsCells
  25. Tomita Y, Fu Z, Wang Z, Cakir B, Cho SS, Britton W, Sun Y, Hellström A, Talukdar S, Smith LEH. Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models. Int J Mol Sci. 2020 Feb 11; 21(4). PMID: 32054022.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  26. Fu Z, Chen CT, Cagnone G, Heckel E, Sun Y, Cakir B, Tomita Y, Huang S, Li Q, Britton W, Cho SS, Kern TS, Hellström A, Joyal JS, Smith LE. Dyslipidemia in retinal metabolic disorders. EMBO Mol Med. 2019 10; 11(10):e10473. PMID: 31486227; PMCID: PMC6783651.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  27. Fu Z, Wang Z, Liu CH, Gong Y, Cakir B, Liegl R, Sun Y, Meng SS, Burnim SB, Arellano I, Moran E, Duran R, Poblete A, Cho SS, Talukdar S, Akula JD, Hellström A, Smith LEH. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018 05; 67(5):974-985. PMID: 29487115; PMCID: PMC5909994.
    Citations: 27     Fields:    Translation:AnimalsCells
  28. Fu Z, Löfqvist CA, Liegl R, Wang Z, Sun Y, Gong Y, Liu CH, Meng SS, Burnim SB, Arellano I, Chouinard MT, Duran R, Poblete A, Cho SS, Akula JD, Kinter M, Ley D, Pupp IH, Talukdar S, Hellström A, Smith LE. Photoreceptor glucose metabolism determines normal retinal vascular growth. EMBO Mol Med. 2018 01; 10(1):76-90. PMID: 29180355.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  29. Pearsall EA, Cheng R, Zhou K, Takahashi Y, Matlock HG, Vadvalkar SS, Shin Y, Fredrick TW, Gantner ML, Meng S, Fu Z, Gong Y, Kinter M, Humphries KM, Szweda LI, Smith LEH, Ma JX. PPARa is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017 Nov 28; 15(1):113. PMID: 29183319; PMCID: PMC5706156.
    Citations: 19     Fields:    Translation:AnimalsCells
  30. Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, Xu X, Yang Q, Zeng X, Zhou Y, Gu X, Lu S, Fu Z, Fulton DJ, Weintraub NL, Caldwell RB, Zhang W, Wu C, Liu XL, Chen JF, Ahmad A, Kaddour-Djebbar I, Al-Shabrawey M, Li Q, Jiang X, Sun Y, Sodhi A, Smith L, Hong M, Huo Y. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun. 2017 09 19; 8(1):584. PMID: 28928465; PMCID: PMC5605640.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  31. Fu Z, Liegl R, Wang Z, Gong Y, Liu CH, Sun Y, Cakir B, Burnim SB, Meng SS, Löfqvist C, SanGiovanni JP, Hellström A, Smith LEH. Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3862-3870. PMID: 28763559; PMCID: PMC5539800.
    Citations: 12     Fields:    Translation:AnimalsCells
  32. Gong Y, Fu Z, Liegl R, Chen J, Hellström A, Smith LE. ?-3 and ?-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases. Am J Clin Nutr. 2017 Jul; 106(1):16-26. PMID: 28515072; PMCID: PMC5486202.
    Citations: 25     Fields:    Translation:Humans
  33. Fu Z, Gong Y, Liegl R, Wang Z, Liu CH, Meng SS, Burnim SB, Saba NJ, Fredrick TW, Morss PC, Hellstrom A, Talukdar S, Smith LE. FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice. Cell Rep. 2017 02 14; 18(7):1606-1613. PMID: 28199833.
    Citations: 19     Fields:    Translation:Animals
  34. Fu Z, Meng SS, Burnim SB, Smith LE, Lo AC. Lutein facilitates physiological revascularization in a mouse model of retinopathy of prematurity. Clin Exp Ophthalmol. 2017 Jul; 45(5):529-538. PMID: 28002872; PMCID: PMC5479763.
    Citations: 8     Fields:    Translation:AnimalsCells
  35. Gong Y, Shao Z, Fu Z, Edin ML, Sun Y, Liegl RG, Wang Z, Liu CH, Burnim SB, Meng SS, Lih FB, SanGiovanni JP, Zeldin DC, Hellström A, Smith LEH. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Nov; 13:201-211. PMID: 27720395.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  36. Gong Y, Fu Z, Edin ML, Liu CH, Wang Z, Shao Z, Fredrick TW, Saba NJ, Morss PC, Burnim SB, Meng SS, Lih FB, Lee KS, Moran EP, SanGiovanni JP, Hellström A, Hammock BD, Zeldin DC, Smith LE. Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1919-27. PMID: 27417579; PMCID: PMC5010176.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  37. Fu Z, Gong Y, Löfqvist C, Hellström A, Smith LE. Review: adiponectin in retinopathy. Biochim Biophys Acta. 2016 08; 1862(8):1392-400. PMID: 27155572; PMCID: PMC4885769.
    Citations: 21     Fields:    Translation:HumansAnimals
  38. Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G, Juan AM, Hurst CG, Hatton CJ, Cui Z, Pierce KA, Bherer P, Aguilar E, Powner MB, Vevis K, Boisvert M, Fu Z, Levy E, Fruttiger M, Packard A, Rezende FA, Maranda B, Sapieha P, Chen J, Friedlander M, Clish CB, Smith LE. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. PMID: 26974308; PMCID: PMC4823176.
    Citations: 111     Fields:    Translation:HumansAnimalsCells
  39. Gong Y, Li J, Sun Y, Fu Z, Liu CH, Evans L, Tian K, Saba N, Fredrick T, Morss P, Chen J, Smith LE. Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. PMID: 26161975.
    Citations: 39     Fields:    Translation:AnimalsCells
  40. Fu Z, Nian S, Li SY, Wong D, Chung SK, Lo AC. Deficiency of aldose reductase attenuates inner retinal neuronal changes in a mouse model of retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2015 Sep; 253(9):1503-13. PMID: 25921391.
    Citations: 13     Fields:    Translation:AnimalsCells
  41. Fu Z, Lofqvist CA, Shao Z, Sun Y, Joyal JS, Hurst CG, Cui RZ, Evans LP, Tian K, SanGiovanni JP, Chen J, Ley D, Hansen Pupp I, Hellstrom A, Smith LE. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. PMID: 25833984; PMCID: PMC4381778.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  42. Li J, Liu CH, Sun Y, Gong Y, Fu Z, Evans LP, Tian KT, Juan AM, Hurst CG, Mammoto A, Chen J. Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20; 55(12):8267-77. PMID: 25414194; PMCID: PMC4541480.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  43. Shao Z, Fu Z, Stahl A, Joyal JS, Hatton C, Juan A, Hurst C, Evans L, Cui Z, Pei D, Gong Y, Xu D, Tian K, Bogardus H, Edin ML, Lih F, Sapieha P, Chen J, Panigrahy D, Hellstrom A, Zeldin DC, Smith LE. Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):581-6. PMID: 24458713.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  44. Lai AKW, Fu Z, Lo ACY. Stem cell therapy for retinopathy of prematurity. Anatomy & Physiology. 2013; 126(3):2161-0940. View Publication.
  45. Li SY, Fu ZJ, Lo AC. Hypoxia-induced oxidative stress in ischemic retinopathy. Oxid Med Cell Longev. 2012; 2012:426769. PMID: 23125893.
    Citations: 49     Fields:    Translation:HumansAnimals
  46. Li SY, Fung FK, Fu ZJ, Wong D, Chan HH, Lo AC. Anti-inflammatory effects of lutein in retinal ischemic/hypoxic injury: in vivo and in vitro studies. Invest Ophthalmol Vis Sci. 2012 Sep 06; 53(10):5976-84. PMID: 22871829.
    Citations: 47     Fields:    Translation:AnimalsCells
  47. Fu ZJ, Li SY, Kociok N, Wong D, Chung SK, Lo AC. Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 Aug 20; 53(9):5698-712. PMID: 22836764.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  48. Li SY, Yang D, Fu ZJ, Woo T, Wong D, Lo AC. Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke. Neurobiol Dis. 2012 Jan; 45(1):624-32. PMID: 22024715.
    Citations: 33     Fields:    Translation:AnimalsCells
  49. Li SY, Fu ZJ, Ma H, Jang WC, So KF, Wong D, Lo AC. Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):836-43. PMID: 18936152.
    Citations: 48     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.