Harvard Catalyst Profiles

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Zhongjie Fu, Ph.D.

Title
Institution
Department
Address

Biography
2015
The Bernadotte Foundation Travel Award
2015
Knights Templar Eye Foundation Pediatric Ophthalmology Career-starter Research Award
2016
Knights Templar Eye Foundation Pediatric Ophthalmology Competitive Renewal Research Award
2017
Asia-ARVO 2017 Travel Grant
2017
Seahorse Bioscience Travel Award
2017
The Blind Children’s Center (BCC) One-year Seed Grant
2018
Boston Children's Hospital The Manton Center Fellowship
2018
Boston Children's Hospital Technology Development Fund (Co-PI)
2019
AOPT Travel Award
2019
Boston Children's Hospital OFD/BTREC/CTREC Career Development Fellowships
2019
The Little Giraffe Foundation Neonatal Research Grant

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wang Z, Liu CH, Huang S, Fu Z, Tomita Y, Britton WR, Cho SS, Chen CT, Sun Y, Ma JX, He X, Chen J. Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier. Sci Adv. 2020 Aug; 6(35):eaba7457. PMID: 32923627.
    Citations:    
  2. Tomita Y, Shao Z, Cakir B, Kotoda Y, Fu Z, Smith LEH. An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis. J Vis Exp. 2020 Aug 06; (162). PMID: 32831307.
    Citations:    
  3. Tomita Y, Cakir B, Liu CH, Fu Z, Huang S, Cho SS, Britton WR, Sun Y, Puder M, Hellström A, Talukdar S, Smith LEH. Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice. Angiogenesis. 2020 08; 23(3):385-394. PMID: 32140799.
    Citations:    
  4. Fu Z, Kern TS, Hellström A, Smith L. Fatty acid oxidation and photoreceptor metabolic needs. J Lipid Res. 2020 Feb 24. PMID: 32094231.
    Citations:    
  5. Fu Z, Sun Y, Cakir B, Tomita Y, Huang S, Wang Z, Liu CH, S Cho S, Britton W, S Kern T, Antonetti DA, Hellström A, E H Smith L. Targeting Neurovascular Interaction in Retinal Disorders. Int J Mol Sci. 2020 Feb 22; 21(4). PMID: 32098361.
    Citations:    
  6. Yanagida K, Engelbrecht E, Niaudet C, Jung B, Gaengel K, Holton K, Swendeman S, Liu CH, Levesque MV, Kuo A, Fu Z, Smith LEH, Betsholtz C, Hla T. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020 Mar 23; 52(6):779-793.e7. PMID: 32059774.
    Citations:    
  7. Tomita Y, Fu Z, Wang Z, Cakir B, Cho SS, Britton W, Sun Y, Hellström A, Talukdar S, Smith LEH. Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models. Int J Mol Sci. 2020 Feb 11; 21(4). PMID: 32054022.
    Citations:    
  8. Fu Z, Chen CT, Cagnone G, Heckel E, Sun Y, Cakir B, Tomita Y, Huang S, Li Q, Britton W, Cho SS, Kern TS, Hellström A, Joyal JS, Smith LE. Dyslipidemia in retinal metabolic disorders. EMBO Mol Med. 2019 10; 11(10):e10473. PMID: 31486227.
    Citations:    
  9. Fu Z, Wang Z, Liu CH, Gong Y, Cakir B, Liegl R, Sun Y, Meng SS, Burnim SB, Arellano I, Moran E, Duran R, Poblete A, Cho SS, Talukdar S, Akula JD, Hellström A, Smith LEH. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018 05; 67(5):974-985. PMID: 29487115.
    Citations:    Fields:    Translation:AnimalsCells
  10. Fu Z, Löfqvist CA, Liegl R, Wang Z, Sun Y, Gong Y, Liu CH, Meng SS, Burnim SB, Arellano I, Chouinard MT, Duran R, Poblete A, Cho SS, Akula JD, Kinter M, Ley D, Pupp IH, Talukdar S, Hellström A, Smith LE. Photoreceptor glucose metabolism determines normal retinal vascular growth. EMBO Mol Med. 2018 01; 10(1):76-90. PMID: 29180355.
    Citations:    Fields:    Translation:HumansAnimalsCells
  11. Pearsall EA, Cheng R, Zhou K, Takahashi Y, Matlock HG, Vadvalkar SS, Shin Y, Fredrick TW, Gantner ML, Meng S, Fu Z, Gong Y, Kinter M, Humphries KM, Szweda LI, Smith LEH, Ma JX. PPARa is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017 Nov 28; 15(1):113. PMID: 29183319.
    Citations: 1     Fields:    Translation:AnimalsCells
  12. Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, Xu X, Yang Q, Zeng X, Zhou Y, Gu X, Lu S, Fu Z, Fulton DJ, Weintraub NL, Caldwell RB, Zhang W, Wu C, Liu XL, Chen JF, Ahmad A, Kaddour-Djebbar I, Al-Shabrawey M, Li Q, Jiang X, Sun Y, Sodhi A, Smith L, Hong M, Huo Y. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun. 2017 09 19; 8(1):584. PMID: 28928465.
    Citations:    Fields:    Translation:HumansAnimalsCells
  13. Fu Z, Liegl R, Wang Z, Gong Y, Liu CH, Sun Y, Cakir B, Burnim SB, Meng SS, Löfqvist C, SanGiovanni JP, Hellström A, Smith LEH. Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3862-3870. PMID: 28763559.
    Citations:    Fields:    Translation:AnimalsCells
  14. Gong Y, Fu Z, Liegl R, Chen J, Hellström A, Smith LE. ?-3 and ?-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases. Am J Clin Nutr. 2017 Jul; 106(1):16-26. PMID: 28515072.
    Citations: 1     Fields:    Translation:Humans
  15. Fu Z, Gong Y, Liegl R, Wang Z, Liu CH, Meng SS, Burnim SB, Saba NJ, Fredrick TW, Morss PC, Hellstrom A, Talukdar S, Smith LE. FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice. Cell Rep. 2017 02 14; 18(7):1606-1613. PMID: 28199833.
    Citations: 1     Fields:    Translation:Animals
  16. Fu Z, Meng SS, Burnim SB, Smith LE, Lo AC. Lutein facilitates physiological revascularization in a mouse model of retinopathy of prematurity. Clin Exp Ophthalmol. 2017 Jul; 45(5):529-538. PMID: 28002872.
    Citations:    Fields:    Translation:AnimalsCells
  17. Gong Y, Shao Z, Fu Z, Edin ML, Sun Y, Liegl RG, Wang Z, Liu CH, Burnim SB, Meng SS, Lih FB, SanGiovanni JP, Zeldin DC, Hellström A, Smith LEH. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Nov; 13:201-211. PMID: 27720395.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  18. Gong Y, Fu Z, Edin ML, Liu CH, Wang Z, Shao Z, Fredrick TW, Saba NJ, Morss PC, Burnim SB, Meng SS, Lih FB, Lee KS, Moran EP, SanGiovanni JP, Hellström A, Hammock BD, Zeldin DC, Smith LE. Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1919-27. PMID: 27417579.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  19. Fu Z, Gong Y, Löfqvist C, Hellström A, Smith LE. Review: adiponectin in retinopathy. Biochim Biophys Acta. 2016 08; 1862(8):1392-400. PMID: 27155572.
    Citations: 6     Fields:    
  20. Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G, Juan AM, Hurst CG, Hatton CJ, Cui Z, Pierce KA, Bherer P, Aguilar E, Powner MB, Vevis K, Boisvert M, Fu Z, Levy E, Fruttiger M, Packard A, Rezende FA, Maranda B, Sapieha P, Chen J, Friedlander M, Clish CB, Smith LE. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. PMID: 26974308.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  21. Gong Y, Li J, Sun Y, Fu Z, Liu CH, Evans L, Tian K, Saba N, Fredrick T, Morss P, Chen J, Smith LE. Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. PMID: 26161975.
    Citations: 13     Fields:    Translation:AnimalsCells
  22. Fu Z, Nian S, Li SY, Wong D, Chung SK, Lo AC. Deficiency of aldose reductase attenuates inner retinal neuronal changes in a mouse model of retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2015 Sep; 253(9):1503-13. PMID: 25921391.
    Citations: 2     Fields:    Translation:AnimalsCells
  23. Fu Z, Lofqvist CA, Shao Z, Sun Y, Joyal JS, Hurst CG, Cui RZ, Evans LP, Tian K, SanGiovanni JP, Chen J, Ley D, Hansen Pupp I, Hellstrom A, Smith LE. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. PMID: 25833984.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  24. Li J, Liu CH, Sun Y, Gong Y, Fu Z, Evans LP, Tian KT, Juan AM, Hurst CG, Mammoto A, Chen J. Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20; 55(12):8267-77. PMID: 25414194.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  25. Shao Z, Fu Z, Stahl A, Joyal JS, Hatton C, Juan A, Hurst C, Evans L, Cui Z, Pei D, Gong Y, Xu D, Tian K, Bogardus H, Edin ML, Lih F, Sapieha P, Chen J, Panigrahy D, Hellstrom A, Zeldin DC, Smith LE. Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):581-6. PMID: 24458713.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  26. Lai AKW, Fu Z, Lo ACY. Stem cell therapy for retinopathy of prematurity. Anatomy & Physiology. 2013; 126(3):2161-0940. View Publication.
  27. Li SY, Fu ZJ, Lo AC. Hypoxia-induced oxidative stress in ischemic retinopathy. Oxid Med Cell Longev. 2012; 2012:426769. PMID: 23125893.
    Citations: 24     Fields:    Translation:HumansAnimals
  28. Li SY, Fung FK, Fu ZJ, Wong D, Chan HH, Lo AC. Anti-inflammatory effects of lutein in retinal ischemic/hypoxic injury: in vivo and in vitro studies. Invest Ophthalmol Vis Sci. 2012 Sep 06; 53(10):5976-84. PMID: 22871829.
    Citations: 19     Fields:    Translation:AnimalsCells
  29. Fu ZJ, Li SY, Kociok N, Wong D, Chung SK, Lo AC. Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 Aug 20; 53(9):5698-712. PMID: 22836764.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  30. Li SY, Yang D, Fu ZJ, Woo T, Wong D, Lo AC. Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke. Neurobiol Dis. 2012 Jan; 45(1):624-32. PMID: 22024715.
    Citations: 17     Fields:    Translation:AnimalsCells
  31. Li SY, Fu ZJ, Ma H, Jang WC, So KF, Wong D, Lo AC. Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):836-43. PMID: 18936152.
    Citations: 31     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.