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Agnieszka M Bronisz, Ph.D.

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The rationale of my work is forthright: cancer is a complex genetic disease involving expressional abnormalities of both protein-coding and non-coding genes which together form complex RNA networks within the molecular microcosm that are not yet fully recognized.

While significant effort has been dedicated to identify sequence and expression alterations of protein-coding genes, contributing vastly to our understanding of brain tumor; little is known about functional consequences of alterations in ncRNAs. Additional layer of complexity are microenvironmental rearrangements contributing to intra-tumoral heterogeneity inducing abnormalities/alteration of gene expression. Such phenotypical diversity can be rendered even more complex by the inter-cellular transfer of functional molecules encapsulated in exosomes. My research plan is to develop three major branches of the project that are focused on: ncRNA tumor heterogeneity, ncRNA exosome cargo and ncRNA-ncRNA network.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bratek-Gerej E, Bronisz A, Ziembowicz A, Salinska E. Pretreatment with mGluR2 or mGluR3 Agonists Reduces Apoptosis Induced by Hypoxia-Ischemia in Neonatal Rat Brains. Oxid Med Cell Longev. 2021; 2021:8848015. PMID: 33763176.
    Citations:    Fields:    
  2. Kitamura Y, Kanaya N, Moleirinho S, Du W, Reinshagen C, Attia N, Bronisz A, Revai Lechtich E, Sasaki H, Mora JL, Brastianos PK, Falcone JL, Hofer AM, Franco A, Shah K. Anti-EGFR VHH-armed death receptor ligand-engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers. Sci Adv. 2021 Mar; 7(10). PMID: 33658202.
    Citations:    Fields:    
  3. Bronisz A, Rooj AK, Krawczynski K, Peruzzi P, Salinska E, Nakano I, Purow B, Chiocca EA, Godlewski J. The nuclear DICER-circular RNA complex drives the deregulation of the glioblastoma cell microRNAome. Sci Adv. 2020 Dec; 6(51). PMID: 33328224.
    Citations: 1     Fields:    
  4. Krawczynski K, Godlewski J, Bronisz A. Oxidative Stress-Part of the Solution or Part of the Problem in the Hypoxic Environment of a Brain Tumor. Antioxidants (Basel). 2020 Aug 14; 9(8). PMID: 32823815.
    Citations: 1     
  5. Bronisz A, Salinska E, Chiocca EA, Godlewski J. Hypoxic Roadmap of Glioblastoma-Learning about Directions and Distances in the Brain Tumor Environment. Cancers (Basel). 2020 May 13; 12(5). PMID: 32413951.
    Citations: 2     
  6. Ogawa D, Ansari K, Nowicki MO, Salinska E, Bronisz A, Godlewski J. MicroRNA-451 Inhibits Migration of Glioblastoma while Making It More Susceptible to Conventional Therapy. Noncoding RNA. 2019 Mar 15; 5(1). PMID: 30875963.
    Citations: 10     
  7. Xiao A, Brenneman B, Floyd D, Comeau L, Spurio K, Olmez I, Lee J, Nakano I, Godlewski J, Bronisz A, Kagaya N, Shin-Ya K, Purow B. Statins affect human glioblastoma and other cancers through TGF-ß inhibition. Oncotarget. 2019 Mar 01; 10(18):1716-1728. PMID: 30899443.
    Citations: 4     Fields:    
  8. Bhaskaran V, Nowicki MO, Idriss M, Jimenez MA, Lugli G, Hayes JL, Mahmoud AB, Zane RE, Passaro C, Ligon KL, Haas-Kogan D, Bronisz A, Godlewski J, Lawler SE, Chiocca EA, Peruzzi P. The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma. Nat Commun. 2019 01 25; 10(1):442. PMID: 30683859.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  9. Jun HJ, Appleman VA, Wu HJ, Rose CM, Pineda JJ, Yeo AT, Delcuze B, Lee C, Gyuris A, Zhu H, Woolfenden S, Bronisz A, Nakano I, Chiocca EA, Bronson RT, Ligon KL, Sarkaria JN, Gygi SP, Michor F, Mitchison TJ, Charest A. A PDGFRa-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nat Commun. 2018 08 06; 9(1):3116. PMID: 30082792.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  10. Bratek E, Ziembowicz A, Bronisz A, Salinska E. The activation of group II metabotropic glutamate receptors protects neonatal rat brains from oxidative stress injury after hypoxia-ischemia. PLoS One. 2018; 13(7):e0200933. PMID: 30044838.
    Citations: 7     Fields:    Translation:Animals
  11. Olmez I, Zhang Y, Manigat L, Benamar M, Brenneman B, Nakano I, Godlewski J, Bronisz A, Lee J, Abbas T, Abounader R, Purow B. Combined c-Met/Trk Inhibition Overcomes Resistance to CDK4/6 Inhibitors in Glioblastoma. Cancer Res. 2018 08 01; 78(15):4360-4369. PMID: 29844123.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  12. Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA. Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Sci Adv. 2018 03; 4(3):eaar2766. PMID: 29532035.
    Citations: 93     Fields:    Translation:HumansCells
  13. Olmez I, Love S, Xiao A, Manigat L, Randolph P, McKenna BD, Neal BP, Boroda S, Li M, Brenneman B, Abounader R, Floyd D, Lee J, Nakano I, Godlewski J, Bronisz A, Sulman EP, Mayo M, Gioeli D, Weber M, Harris TE, Purow B. Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha. Neuro Oncol. 2018 01 22; 20(2):192-202. PMID: 29048560.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  14. Speranza MC, Passaro C, Ricklefs F, Kasai K, Klein SR, Nakashima H, Kaufmann JK, Ahmed AK, Nowicki MO, Obi P, Bronisz A, Aguilar-Cordova E, Aguilar LK, Guzik BW, Breakefield X, Weissleder R, Freeman GJ, Reardon DA, Wen PY, Chiocca EA, Lawler SE. Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma. Neuro Oncol. 2018 01 22; 20(2):225-235. PMID: 29016938.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  15. Olmez I, Brenneman B, Xiao A, Serbulea V, Benamar M, Zhang Y, Manigat L, Abbas T, Lee J, Nakano I, Godlewski J, Bronisz A, Abounader R, Leitinger N, Purow B. Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms. Clin Cancer Res. 2017 Nov 15; 23(22):6958-6968. PMID: 28814434.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  16. Li M, Xiao A, Floyd D, Olmez I, Lee J, Godlewski J, Bronisz A, Bhat KPL, Sulman EP, Nakano I, Purow B. CDK4/6 inhibition is more active against the glioblastoma proneural subtype. Oncotarget. 2017 Aug 15; 8(33):55319-55331. PMID: 28903422.
    Citations: 12     Fields:    
  17. Rooj AK, Ricklefs F, Mineo M, Nakano I, Chiocca EA, Bronisz A, Godlewski J. MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. Cell Rep. 2017 06 06; 19(10):2026-2032. PMID: 28591575.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  18. Godlewski J, Ferrer-Luna R, Rooj AK, Mineo M, Ricklefs F, Takeda YS, Nowicki MO, Salinska E, Nakano I, Lee H, Weissleder R, Beroukhim R, Chiocca EA, Bronisz A. MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer. Stem Cell Reports. 2017 06 06; 8(6):1497-1505. PMID: 28528698.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  19. Mineo M, Ricklefs F, Rooj AK, Lyons SM, Ivanov P, Ansari KI, Nakano I, Chiocca EA, Godlewski J, Bronisz A. The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. Cell Rep. 2016 06 14; 15(11):2500-9. PMID: 27264189.
    Citations: 67     Fields:    Translation:HumansCells
  20. Ricklefs F, Mineo M, Rooj AK, Nakano I, Charest A, Weissleder R, Breakefield XO, Chiocca EA, Godlewski J, Bronisz A. Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity. Cancer Res. 2016 05 15; 76(10):2876-81. PMID: 27013191.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  21. Bronisz A, Godlewski J, Chiocca EA. Extracellular Vesicles and MicroRNAs: Their Role in Tumorigenicity and Therapy for Brain Tumors. Cell Mol Neurobiol. 2016 Apr; 36(3):361-76. PMID: 26983830.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  22. Rooj AK, Bronisz A, Godlewski J. The role of octamer binding transcription factors in glioblastoma multiforme. Biochim Biophys Acta. 2016 Jun; 1859(6):805-11. PMID: 26968235.
    Citations: 6     Fields:    Translation:HumansCells
  23. Carey HA, Bronisz A, Cabrera J, Hildreth BE, Cuitiño M, Fu Q, Ahmad A, Toribio RE, Ostrowski MC, Sharma SM. Failure to Target RANKL Signaling Through p38-MAPK Results in Defective Osteoclastogenesis in the Microphthalmia Cloudy-Eyed Mutant. J Cell Physiol. 2016 Mar; 231(3):630-40. PMID: 26218069.
    Citations: 3     Fields:    Translation:AnimalsCells
  24. Bronisz A, Chiocca EA, Godlewski J. Response to energy depletion: miR-451/AMPK loop. Oncotarget. 2015 Jul 20; 6(20):17851-2. PMID: 26257001.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  25. Bronisz A, Chiocca EA. A cross-talk network that facilitates tumor virotherapy. Nat Med. 2015 May; 21(5):426-7. PMID: 25951527.
    Citations:    Fields:    Translation:HumansAnimalsCells
  26. Ansari KI, Ogawa D, Rooj AK, Lawler SE, Krichevsky AM, Johnson MD, Chiocca EA, Bronisz A, Godlewski J. Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor. Cell Rep. 2015 May 12; 11(6):902-909. PMID: 25937278.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  27. Godlewski J, Krichevsky AM, Johnson MD, Chiocca EA, Bronisz A. Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment. Neuro Oncol. 2015 May; 17(5):652-62. PMID: 25301812.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  28. Kabbout M, Dakhlallah D, Sharma S, Bronisz A, Srinivasan R, Piper M, Marsh CB, Ostrowski MC. MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation. PLoS One. 2014; 9(6):e100693. PMID: 24968297.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  29. Bronisz A, Wang Y, Nowicki MO, Peruzzi P, Ansari K, Ogawa D, Balaj L, De Rienzo G, Mineo M, Nakano I, Ostrowski MC, Hochberg F, Weissleder R, Lawler SE, Chiocca EA, Godlewski J. Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. Cancer Res. 2014 Feb 01; 74(3):738-750. PMID: 24310399.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  30. Bronisz A, Carey HA, Godlewski J, Sif S, Ostrowski MC, Sharma SM. The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF). J Biol Chem. 2014 Jan 03; 289(1):326-34. PMID: 24257758.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  31. Peruzzi P, Bronisz A, Nowicki MO, Wang Y, Ogawa D, Price R, Nakano I, Kwon CH, Hayes J, Lawler SE, Ostrowski MC, Chiocca EA, Godlewski J. MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells. Neuro Oncol. 2013 Sep; 15(9):1212-24. PMID: 23733246.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  32. He H, Bronisz A, Liyanarachchi S, Nagy R, Li W, Huang Y, Akagi K, Saji M, Kula D, Wojcicka A, Sebastian N, Wen B, Puch Z, Kalemba M, Stachlewska E, Czetwertynska M, Dlugosinska J, Dymecka K, Ploski R, Krawczyk M, Morrison PJ, Ringel MD, Kloos RT, Jazdzewski K, Symer DE, Vieland VJ, Ostrowski M, Jarzab B, de la Chapelle A. SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility. J Clin Endocrinol Metab. 2013 May; 98(5):E973-80. PMID: 23539728.
    Citations: 24     Fields:    Translation:HumansCells
  33. Leicht DT, Balan V, Zhu J, Kaplun A, Bronisz A, Rana A, Tzivion G. MEK-1 activates C-Raf through a Ras-independent mechanism. Biochim Biophys Acta. 2013 May; 1833(5):976-86. PMID: 23360980.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  34. Bronisz A, Godlewski J, Wallace JA, Merchant AS, Nowicki MO, Mathsyaraja H, Srinivasan R, Trimboli AJ, Martin CK, Li F, Yu L, Fernandez SA, Pécot T, Rosol TJ, Cory S, Hallett M, Park M, Piper MG, Marsh CB, Yee LD, Jimenez RE, Nuovo G, Lawler SE, Chiocca EA, Leone G, Ostrowski MC. Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nat Cell Biol. 2011 Dec 18; 14(2):159-67. PMID: 22179046.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  35. Godlewski J, Bronisz A, Nowicki MO, Chiocca EA, Lawler S. microRNA-451: A conditional switch controlling glioma cell proliferation and migration. Cell Cycle. 2010 Jul 15; 9(14):2742-8. PMID: 20647762.
    Citations: 77     Fields:    Translation:HumansCells
  36. Godlewski J, Nowicki MO, Bronisz A, Nuovo G, Palatini J, De Lay M, Van Brocklyn J, Ostrowski MC, Chiocca EA, Lawler SE. MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Mol Cell. 2010 Mar 12; 37(5):620-32. PMID: 20227367.
    Citations: 181     Fields:    Translation:HumansAnimalsCells
  37. Godlewski J, Nowicki MO, Bronisz A, Williams S, Otsuki A, Nuovo G, Raychaudhury A, Newton HB, Chiocca EA, Lawler S. Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 2008 Nov 15; 68(22):9125-30. PMID: 19010882.
    Citations: 325     Fields:    Translation:HumansAnimalsCells
  38. Hume DA, Sasmono T, Himes SR, Sharma SM, Bronisz A, Constantin M, Ostrowski MC, Ross IL. The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene. J Immunol. 2008 May 15; 180(10):6733-42. PMID: 18453593.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  39. Hu R, Sharma SM, Bronisz A, Srinivasan R, Sankar U, Ostrowski MC. Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors. Mol Cell Biol. 2007 Jun; 27(11):4018-27. PMID: 17403896.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  40. Sharma SM, Bronisz A, Hu R, Patel K, Mansky KC, Sif S, Ostrowski MC. MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation. J Biol Chem. 2007 May 25; 282(21):15921-9. PMID: 17403683.
    Citations: 66     Fields:    Translation:AnimalsCells
  41. Bronisz A, Sharma SM, Hu R, Godlewski J, Tzivion G, Mansky KC, Ostrowski MC. Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors. Mol Biol Cell. 2006 Sep; 17(9):3897-906. PMID: 16822840.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  42. Sharma SM, Hu R, Bronisz A, Meadows N, Lusby T, Fletcher B, Hume DA, Cassady AI, Ostrowski MC. Genetics and genomics of osteoclast differentiation: integrating cell signaling pathways and gene networks. Crit Rev Eukaryot Gene Expr. 2006; 16(3):253-77. PMID: 17073554.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  43. Zhu J, Balan V, Bronisz A, Balan K, Sun H, Leicht DT, Luo Z, Qin J, Avruch J, Tzivion G. Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. Mol Biol Cell. 2005 Oct; 16(10):4733-44. PMID: 16093354.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  44. Shen YH, Godlewski J, Bronisz A, Zhu J, Comb MJ, Avruch J, Tzivion G. Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding. Mol Biol Cell. 2003 Nov; 14(11):4721-33. PMID: 14551260.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  45. Slupianek A, Hoser G, Majsterek I, Bronisz A, Malecki M, Blasiak J, Fishel R, Skorski T. Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis. Mol Cell Biol. 2002 Jun; 22(12):4189-201. PMID: 12024032.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  46. Bronisz A, Gajkowska B, Domanska-Janik K. PKC and Raf-1 inhibition-related apoptotic signalling in N2a cells. J Neurochem. 2002 Jun; 81(6):1176-84. PMID: 12068066.
    Citations: 2     Fields:    Translation:AnimalsCells
  47. Domanska-Janik K, Bronisz-Kowalczyk A, Zajac H, Zablocka B. Interrelations between nuclear-factor kappa B activation, glial response and neuronal apoptosis in gerbil hippocampus after ischemia. Acta Neurobiol Exp (Wars). 2001; 61(1):45-51. PMID: 11315321.
    Citations: 4     Fields:    Translation:AnimalsCells
  48. Bronisz-Kowalczyk A, Buzanska L, Kowalczyk D, Domanska-Janik K. Extracellular signal-regulated kinase suppression is not involved in apoptosis of neuroblastoma N2a cells induced by protein kinase C inhibition. Folia Neuropathol. 2000; 38(1):13-21. PMID: 11057029.
    Citations: 1     Fields:    Translation:AnimalsCells
  49. Domanska-Janik K, Bong P, Bronisz-Kowalczyk A, Zajac H, Zablocka B. AP1 transcriptional factor activation and its relation to apoptosis of hippocampal CA1 pyramidal neurons after transient ischemia in gerbils. J Neurosci Res. 1999 Sep 15; 57(6):840-6. PMID: 10467255.
    Citations: 7     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.