Agnieszka M Bronisz, Ph.D.
Assistant Professor of Neurosurgery
Brigham and Women's Hospital
Brigham and Womens Hospital
75 Francis St
Boston MA 02115
The rationale of my work is forthright: cancer is a complex genetic disease involving expressional abnormalities of both protein-coding and non-coding genes which together form complex RNA networks within the molecular microcosm that are not yet fully recognized.
While significant effort has been dedicated to identify sequence and expression alterations of protein-coding genes, contributing vastly to our understanding of brain tumor; little is known about functional consequences of alterations in ncRNAs. Additional layer of complexity are microenvironmental rearrangements contributing to intra-tumoral heterogeneity inducing abnormalities/alteration of gene expression. Such phenotypical diversity can be rendered even more complex by the inter-cellular transfer of functional molecules encapsulated in exosomes. My research plan is to develop three major branches of the project that are focused on: ncRNA tumor heterogeneity, ncRNA exosome cargo and ncRNA-ncRNA network.
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