Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

profileMarie Demay, M.D.

TitleProfessor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Endocrine Unit, THR 1101
55 Fruit St
Boston MA 02114
Phone617/726-3273
Fax617/726-7543
vCardDownload vCard (login for email)

Collapse Mentoring 
Collapse current student opportunities
Available: 05/29/14, Expires: 06/30/18

We have demonstrated that rickets is secondary to impaired hypertrophic chondrocyte apoptosis, and that phosphate ions induce apoptosis of these cells by activating the mitochondrial apoptotic pathway. Erk1/2 phosphorylation by MEK is a key component of this signaling cascade. The studies proposed will identify the role of PTH and PTHrP, vitamin D and bisphosphonates on apoptosis of hypertrophic chondrocytes. Investigations will be performed in vitro in primary chondrocytes, as well as in vivo in genetically engineered mice. These studies will examine the pathway between Erk1/2 phosphorylation and hypertrophic chondrocyte apoptosis. Studies in mice lacking C-Raf in chondrocytes will determine whether this signaling molecule lies upstream of Mek.

Studies will also determine whether bisphosphonates modulate hypertrophic chondrocyte apoptosis in response to phosphate, and whether they alter the biomechanical integrity of growing bone. Student may assume the lead for the in vivo or in vitro project, or choose to work with a postdoctoral fellow. Time commitment will be determined by the investment the student is able to make.


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
P30AR066261     (KRONENBERG, HENRY M.)Jun 1, 2014 - May 31, 2019
NIH/NIAMS
CENTER FOR SKELETAL RESEARCH
Role: Co-Principal Investigator

R01AR061376     (DEMAY, MARIE)Sep 1, 2011 - Aug 31, 2016
NIH/NIAMS
Etiology and Therapy of Rickets in the Hyp mouse model of XLH
Role: Principal Investigator

R01AR059145     (DEMAY, MARIE)Sep 1, 2010 - Jun 30, 2014
NIH/NIAMS
Comparison of Bisphosphonate Treatment Regimens on Skeletal Growth &Biomechanics
Role: Principal Investigator

P50AR054086     (CARPENTER, THOMAS O)Jul 1, 2006 - Aug 31, 2012
NIH/NIAMS
NIAMS: CORT
Role: Co-Principal Investigator

P01DK056246     (TABIN, CLIFFORD J)Aug 20, 1999 - May 31, 2016
NIH/NIDDK
Developmental Regulation of Bone Morphogenesis
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Rolvien T, Krause M, Jeschke A, Yorgan T, Püschel K, Schinke T, Busse B, Demay MB, Amling M. Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone. Bone. 2017 Oct; 103:78-87. PMID: 28666969.
    View in: PubMed
  2. Li Y, Caballero D, Ponsetto J, Chen A, Zhu C, Guo J, Demay M, Jüppner H, Bergwitz C. Response of Npt2a knockout mice to dietary calcium and phosphorus. PLoS One. 2017; 12(4):e0176232. PMID: 28448530.
    View in: PubMed
  3. Ko FC, Karim L, Brooks DJ, Bouxsein ML, Demay MB. Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice. J Bone Miner Res. 2017 Apr; 32(4):814-820. PMID: 27925290.
    View in: PubMed
  4. Papaioannou G, Petit ET, Liu ES, Baccarini M, Pritchard C, Demay MB. Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development. J Biol Chem. 2017 Feb 24; 292(8):3164-3171. PMID: 28073913.
    View in: PubMed
  5. Saini V, Zhao H, Petit ET, Gori F, Demay MB. Absence of vitamin D receptor (VDR)-mediated PPAR? suppression causes alopecia in VDR-null mice. FASEB J. 2017 Mar; 31(3):1059-1066. PMID: 27932380.
    View in: PubMed
  6. Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB. Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification. Sci Transl Med. 2016 Nov 23; 8(366):366ra163. PMID: 27881824.
    View in: PubMed
  7. Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB. Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. J Bone Miner Res. 2016 Dec; 31(12):2204-2214. PMID: 27324177.
    View in: PubMed
  8. Lips P, Welsh J, Demay M, Bouillon R. Highlights from the 18th workshop on vitamin D, Delft, The Netherlands, April 21-24, 2015. J Steroid Biochem Mol Biol. 2016 Nov; 164:1-3. PMID: 27969101.
    View in: PubMed
  9. Song L, Papaioannou G, Zhao H, Luderer HF, Miller C, Dall'Osso C, Nazarian RM, Wagers AJ, Demay MB. The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury. Endocrinology. 2016 Oct; 157(10):4066-4075. PMID: 27526034.
    View in: PubMed
  10. Liu ES, Martins JS, Raimann A, Chae BT, Brooks DJ, Jorgetti V, Bouxsein ML, Demay MB. 1,25-Dihydroxyvitamin D Alone Improves Skeletal Growth, Microarchitecture, and Strength in a Murine Model of XLH, Despite Enhanced FGF23 Expression. J Bone Miner Res. 2016 May; 31(5):929-39. PMID: 26751835; PMCID: PMC4862933 [Available on 05/01/17].
  11. Liu ES, Raimann A, Chae BT, Martins JS, Baccarini M, Demay MB. c-Raf promotes angiogenesis during normal growth plate maturation. Development. 2016 Jan 15; 143(2):348-55. PMID: 26657770; PMCID: PMC4725343 [Available on 01/15/17].
  12. Lisse TS, Saini V, Zhao H, Luderer HF, Gori F, Demay MB. The vitamin D receptor is required for activation of cWnt and hedgehog signaling in keratinocytes. Mol Endocrinol. 2014 Oct; 28(10):1698-706. PMID: 25180455; PMCID: PMC4179637.
  13. Liu ES, Zalutskaya A, Chae BT, Zhu ED, Gori F, Demay MB. Phosphate interacts with PTHrP to regulate endochondral bone formation. Endocrinology. 2014 Oct; 155(10):3750-6. PMID: 25057796; PMCID: PMC4164920.
  14. Zhu ED, Louis L, Brooks DJ, Bouxsein ML, Demay MB. Effect of bisphosphonates on the rapidly growing male murine skeleton. Endocrinology. 2014 Apr; 155(4):1188-96. PMID: 24422540; PMCID: PMC3959604.
  15. Luderer HF, Nazarian RM, Zhu ED, Demay MB. Ligand-dependent actions of the vitamin D receptor are required for activation of TGF-ß signaling during the inflammatory response to cutaneous injury. Endocrinology. 2013 Jan; 154(1):16-24. PMID: 23132743; PMCID: PMC3529380.
  16. Demay MB. Physiological insights from the vitamin D receptor knockout mouse. Calcif Tissue Int. 2013 Feb; 92(2):99-105. PMID: 22903507; PMCID: PMC3511627.
  17. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012 Jun; 33(3):456-92. PMID: 22596255; PMCID: PMC3365859.
  18. Demay MB. The hair cycle and Vitamin D receptor. Arch Biochem Biophys. 2012 Jul 01; 523(1):19-21. PMID: 22008469.
    View in: PubMed
  19. Luderer HF, Gori F, Demay MB. Lymphoid enhancer-binding factor-1 (LEF1) interacts with the DNA-binding domain of the vitamin D receptor. J Biol Chem. 2011 May 27; 286(21):18444-51. PMID: 21471213; PMCID: PMC3099661.
  20. Bell TD, Demay MB, Burnett-Bowie SA. The biology and pathology of vitamin D control in bone. J Cell Biochem. 2010 Sep 01; 111(1):7-13. PMID: 20506379; PMCID: PMC4020510.
  21. Miedlich SU, Zhu ED, Sabbagh Y, Demay MB. The receptor-dependent actions of 1,25-dihydroxyvitamin D are required for normal growth plate maturation in NPt2a knockout mice. Endocrinology. 2010 Oct; 151(10):4607-12. PMID: 20685875; PMCID: PMC2946147.
  22. Miedlich SU, Zalutskaya A, Zhu ED, Demay MB. Phosphate-induced apoptosis of hypertrophic chondrocytes is associated with a decrease in mitochondrial membrane potential and is dependent upon Erk1/2 phosphorylation. J Biol Chem. 2010 Jun 11; 285(24):18270-5. PMID: 20404333; PMCID: PMC2881751.
  23. Wigner NA, Luderer HF, Cox MK, Sooy K, Gerstenfeld LC, Demay MB. Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2. J Bone Miner Res. 2010 Apr; 25(4):724-33. PMID: 19839770; PMCID: PMC3153327.
  24. Luderer HF, Demay MB. The vitamin D receptor, the skin and stem cells. J Steroid Biochem Mol Biol. 2010 Jul; 121(1-2):314-6. PMID: 20138991.
    View in: PubMed
  25. Zalutskaya AA, Cox MK, Demay MB. Phosphate regulates embryonic endochondral bone development. J Cell Biochem. 2009 Oct 15; 108(3):668-74. PMID: 19681042; PMCID: PMC2972551.
  26. Gori F, Zhu ED, Demay MB. Perichondrial expression of Wdr5 regulates chondrocyte proliferation and differentiation. Dev Biol. 2009 May 01; 329(1):36-43. PMID: 19217897; PMCID: PMC2670346.
  27. Gutierrez GM, Kong E, Sabbagh Y, Brown NE, Lee JS, Demay MB, Thomas DM, Hinds PW. Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18402-7. PMID: 19020086; PMCID: PMC2585042.
  28. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev. 2008 Oct; 29(6):726-76. PMID: 18694980; PMCID: PMC2583388.
  29. Demay MB, Rosenthal DI, Deshpande V. Case records of the Massachusetts General Hospital. Case 16-2008. A 46-year-old woman with bone pain. N Engl J Med. 2008 May 22; 358(21):2266-74. PMID: 18499570.
    View in: PubMed
  30. Zhu ED, Demay MB, Gori F. Wdr5 is essential for osteoblast differentiation. J Biol Chem. 2008 Mar 21; 283(12):7361-7. PMID: 18201971.
    View in: PubMed
  31. Cianferotti L, Cox M, Skorija K, Demay MB. Vitamin D receptor is essential for normal keratinocyte stem cell function. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9428-33. PMID: 17517646; PMCID: PMC1890511.
  32. Cianferotti L, Demay MB. VDR-mediated inhibition of DKK1 and SFRP2 suppresses adipogenic differentiation of murine bone marrow stromal cells. J Cell Biochem. 2007 May 01; 101(1):80-8. PMID: 17212358.
    View in: PubMed
  33. Demay MB, Sabbagh Y, Carpenter TO. Calcium and vitamin D: what is known about the effects on growing bone. Pediatrics. 2007 Mar; 119 Suppl 2:S141-4. PMID: 17332234.
    View in: PubMed
  34. Demay MB, MacDonald PN, Skorija K, Dowd DR, Cianferotti L, Cox M. Role of the vitamin D receptor in hair follicle biology. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):344-6. PMID: 17223342; PMCID: PMC1876678.
  35. Gori F, Friedman LG, Demay MB. Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development. Dev Biol. 2006 Jul 15; 295(2):498-506. PMID: 16730692.
    View in: PubMed
  36. Demay MB. Mechanism of vitamin D receptor action. Ann N Y Acad Sci. 2006 Apr; 1068:204-13. PMID: 16831920.
    View in: PubMed
  37. Gori F, Friedman L, Demay MB. Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo. J Musculoskelet Neuronal Interact. 2005 Oct-Dec; 5(4):338-9. PMID: 16340128.
    View in: PubMed
  38. Sabbagh Y, Carpenter TO, Demay MB. Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9637-42. PMID: 15976027; PMCID: PMC1172249.
  39. Yu X, Sabbagh Y, Davis SI, Demay MB, White KE. Genetic dissection of phosphate- and vitamin D-mediated regulation of circulating Fgf23 concentrations. Bone. 2005 Jun; 36(6):971-7. PMID: 15869926.
    View in: PubMed
  40. Sooy K, Sabbagh Y, Demay MB. Osteoblasts lacking the vitamin D receptor display enhanced osteogenic potential in vitro. J Cell Biochem. 2005 Jan 01; 94(1):81-7. PMID: 15517598.
    View in: PubMed
  41. Gori F, Demay MB. The effects of BIG-3 on osteoblast differentiation are not dependent upon endogenously produced BMPs. Exp Cell Res. 2005 Mar 10; 304(1):287-92. PMID: 15707593.
    View in: PubMed
  42. Skorija K, Cox M, Sisk JM, Dowd DR, MacDonald PN, Thompson CC, Demay MB. Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis. Mol Endocrinol. 2005 Apr; 19(4):855-62. PMID: 15591533.
    View in: PubMed
  43. Masuda S, Byford V, Arabian A, Sakai Y, Demay MB, St-Arnaud R, Jones G. Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse. Endocrinology. 2005 Feb; 146(2):825-34. PMID: 15498883.
    View in: PubMed
  44. Gori F, Demay MB. BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitro. Endocrinology. 2004 Mar; 145(3):1050-4. PMID: 14657013.
    View in: PubMed
  45. Demay M. Muscle: a nontraditional 1,25-dihydroxyvitamin D target tissue exhibiting classic hormone-dependent vitamin D receptor actions. Endocrinology. 2003 Dec; 144(12):5135-7. PMID: 14645209.
    View in: PubMed
  46. Sooy K, Demay MB. Transcriptional repression of the rat osteocalcin gene by deltaEF1. Endocrinology. 2002 Sep; 143(9):3370-5. PMID: 12193549.
    View in: PubMed
  47. Donohue MM, Demay MB. Rickets in VDR null mice is secondary to decreased apoptosis of hypertrophic chondrocytes. Endocrinology. 2002 Sep; 143(9):3691-4. PMID: 12193585.
    View in: PubMed
  48. Chen CH, Sakai Y, Demay MB. Targeting expression of the human vitamin D receptor to the keratinocytes of vitamin D receptor null mice prevents alopecia. Endocrinology. 2001 Dec; 142(12):5386-9. PMID: 11713240.
    View in: PubMed
  49. Gori F, Divieti P, Demay MB. Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation. J Biol Chem. 2001 Dec 07; 276(49):46515-22. PMID: 11551928.
    View in: PubMed
  50. Kearns AE, Donohue MM, Sanyal B, Demay MB. Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro. J Biol Chem. 2001 Nov 09; 276(45):42213-8. PMID: 11500515.
    View in: PubMed
  51. Sakai Y, Kishimoto J, Demay MB. Metabolic and cellular analysis of alopecia in vitamin D receptor knockout mice. J Clin Invest. 2001 Apr; 107(8):961-6. PMID: 11306599; PMCID: PMC199557.
  52. Gori F, Schipani E, Demay MB. Fibromodulin is expressed by both chondrocytes and osteoblasts during fetal bone development. J Cell Biochem. 2001 Apr 2-27; 82(1):46-57. PMID: 11400162.
    View in: PubMed
  53. Merscher S, Funke B, Epstein JA, Heyer J, Puech A, Lu MM, Xavier RJ, Demay MB, Russell RG, Factor S, Tokooya K, Jore BS, Lopez M, Pandita RK, Lia M, Carrion D, Xu H, Schorle H, Kobler JB, Scambler P, Wynshaw-Boris A, Skoultchi AI, Morrow BE, Kucherlapati R. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell. 2001 Feb 23; 104(4):619-29. PMID: 11239417.
    View in: PubMed
  54. Thomas MK, Demay MB. Vitamin D deficiency and disorders of vitamin D metabolism. Endocrinol Metab Clin North Am. 2000 Sep; 29(3):611-27, viii. PMID: 11033763.
    View in: PubMed
  55. Kearns AE, Demay MB. BMP-2 induces the expression of activin betaA and follistatin in vitro. J Cell Biochem. 2000 Jul 19; 79(1):80-8. PMID: 10906757.
    View in: PubMed
  56. St-Arnaud R, Arabian A, Travers R, Barletta F, Raval-Pandya M, Chapin K, Depovere J, Mathieu C, Christakos S, Demay MB, Glorieux FH. Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D. Endocrinology. 2000 Jul; 141(7):2658-66. PMID: 10875271.
    View in: PubMed
  57. Sakai Y, Demay MB. Evaluation of keratinocyte proliferation and differentiation in vitamin D receptor knockout mice. Endocrinology. 2000 Jun; 141(6):2043-9. PMID: 10830288.
    View in: PubMed
  58. Amling M, Priemel M, Holzmann T, Chapin K, Rueger JM, Baron R, Demay MB. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology. 1999 Nov; 140(11):4982-7. PMID: 10537122.
    View in: PubMed
  59. Amling M, Priemel M, Holzmann T, Chapin K, Rueger JM, Baron R, Demay MB. Rescue of the Skeletal Phenotype of Vitamin D Receptor-Ablated Mice in the Setting of Normal Mineral Ion Homeostasis: Formal Histomorphometric and Biomechanical Analyses1. Endocrinology. 1999 Nov 01; 140(11):4982-4987. PMID: 28200431.
    View in: PubMed
  60. Kearns AE, Goto K, Gianakakos G, Lippmann W, Demay MB. Transcriptional repression of the rat osteocalcin gene: role of two intronic CCTCCT motifs. Endocrinology. 1999 Sep; 140(9):4120-6. PMID: 10465284.
    View in: PubMed
  61. Kearns AE, Goto K, Gianakakos G, Lippmann W, Demay MB. Transcriptional Repression of the Rat Osteocalcin Gene: Role of Two Intronic CCTCCT Motifs1. Endocrinology. 1999 Sep 01; 140(9):4120-4126. PMID: 28200814.
    View in: PubMed
  62. Sneddon WB, Demay MB. Characterization of an enhancer required for 1,25-dihydroxyvitamin D3-dependent transactivation of the rat osteocalcin gene. J Cell Biochem. 1999 Jun 01; 73(3):400-7. PMID: 10321839.
    View in: PubMed
  63. Li YC, Amling M, Pirro AE, Priemel M, Meuse J, Baron R, Delling G, Demay MB. Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice* * This work was supported by NIH Grants DK-46974 (to M.B.D.) and DE-04724 (to R.B.) and a NIH National Research Service Award (to Y.C.L.). Endocrinology. 1998 Oct 01; 139(10):4391-4396. PMID: 28200198.
    View in: PubMed
  64. Li YC, Amling M, Pirro AE, Priemel M, Meuse J, Baron R, Delling G, Demay MB. Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology. 1998 Oct; 139(10):4391-6. PMID: 9751523.
    View in: PubMed
  65. Li YC, Pirro AE, Demay MB. Analysis of vitamin D-dependent calcium-binding protein messenger ribonucleic acid expression in mice lacking the vitamin D receptor. Endocrinology. 1998 Mar; 139(3):847-51. PMID: 9492012.
    View in: PubMed
  66. Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R, Demay MB. Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci U S A. 1997 Sep 02; 94(18):9831-5. PMID: 9275211; PMCID: PMC23277.
  67. Li YC, Bergwitz C, Jüppner H, Demay MB. Cloning and characterization of the vitamin D receptor from Xenopus laevis. Endocrinology. 1997 Jun; 138(6):2347-53. PMID: 9165021.
    View in: PubMed
  68. Li YC, Bergwitz C, Ju Ppner H, Demay MB. Cloning and Characterization of the Vitamin D Receptor from Xenopus laevis. Endocrinology. 1997 Jun 01; 138(6):2347-2353. PMID: 28199616.
    View in: PubMed
  69. Sneddon WB, Bogado CE, Kiernan MS, Demay MB. DNA sequences downstream from the vitamin D response element of the rat osteocalcin gene are required for ligand-dependent transactivation. Mol Endocrinol. 1997 Feb; 11(2):210-7. PMID: 9013768.
    View in: PubMed
  70. Goto K, Heymont JL, Klein-Nulend J, Kronenberg HM, Demay MB. Identification of an osteoblastic silencer element in the first intron of the rat osteocalcin gene. Biochemistry. 1996 Aug 20; 35(33):11005-11. PMID: 8718894.
    View in: PubMed
  71. Mackey SL, Heymont JL, Kronenberg HM, Demay MB. Vitamin D receptor binding to the negative human parathyroid hormone vitamin D response element does not require the retinoid x receptor. Mol Endocrinol. 1996 Mar; 10(3):298-305. PMID: 8833658.
    View in: PubMed
  72. Nanes MS, Kuno H, Demay MB, Kurian M, Hendy GN, DeLuca HF, Titus L, Rubin J. A single up-stream element confers responsiveness to 1,25-dihydroxyvitamin D3 and tumor necrosis factor-alpha in the rat osteocalcin gene. Endocrinology. 1994 Mar; 134(3):1113-20. PMID: 8119149.
    View in: PubMed
  73. Demay MB, Kiernan MS, DeLuca HF, Kronenberg HM. Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A. 1992 Sep 01; 89(17):8097-101. PMID: 1325645; PMCID: PMC49863.
  74. Demay MB, Kiernan MS, DeLuca HF, Kronenberg HM. Characterization of 1,25-dihydroxyvitamin D3 receptor interactions with target sequences in the rat osteocalcin gene. Mol Endocrinol. 1992 Apr; 6(4):557-62. PMID: 1316548.
    View in: PubMed
  75. Demay MB, Gerardi JM, DeLuca HF, Kronenberg HM. DNA sequences in the rat osteocalcin gene that bind the 1,25-dihydroxyvitamin D3 receptor and confer responsiveness to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):369-73. PMID: 2153298; PMCID: PMC53265.
  76. Demay MB, Roth DA, Kronenberg HM. Regions of the rat osteocalcin gene which mediate the effect of 1,25-dihydroxyvitamin D3 on gene transcription. J Biol Chem. 1989 Feb 05; 264(4):2279-82. PMID: 2783691.
    View in: PubMed
  77. Khosla S, Demay M, Pines M, Hurwitz S, Potts JT, Kronenberg HM. Nucleotide sequence of cloned cDNAs encoding chicken preproparathyroid hormone. J Bone Miner Res. 1988 Dec; 3(6):689-98. PMID: 3251402.
    View in: PubMed
  78. Demay M, Mitchell J, Goltzman D. Comparison of renal and osseous binding of parathyroid hormone and hormonal fragments. Am J Physiol. 1985 Nov; 249(5 Pt 1):E437-46. PMID: 3864382.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Demay's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
_
Co-Authors Expand Description
_
Similar People Expand Description
_
Same Department Expand Description
Physical Neighbors Expand Description
_