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Joerg Ermann, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03AR066357 (ERMANN, JOERG) Sep 12, 2014 - Aug 31, 2017
    Analyzing Disease Mechanisms in a Mouse Model of Spondyloarthritis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Magrey MN, Danve AS, Ermann J, Walsh JA. Recognizing Axial Spondyloarthritis: A Guide for Primary Care. Mayo Clin Proc. 2020 Jul 29. PMID: 32736944.
  2. Ashrafi M, Ermann J, Weisman MH. Spondyloarthritis evolution: what is in your history? Curr Opin Rheumatol. 2020 Jul; 32(4):321-329. PMID: 32453039.
  3. Ermann J. Pathogenesis of Axial Spondyloarthritis - Sources and Current State of Knowledge. Rheum Dis Clin North Am. 2020 May; 46(2):193-206. PMID: 32340695.
  4. Zhao SS, Hong C, Cai T, Xu C, Huang J, Ermann J, Goodson NJ, Solomon DH, Cai T, Liao KP. Incorporating natural language processing to improve classification of axial spondyloarthritis using electronic health records. Rheumatology (Oxford). 2020 05 01; 59(5):1059-1065. PMID: 31535693.
  5. Gutierrez-Arcelus M, Baglaenko Y, Arora J, Hannes S, Luo Y, Amariuta T, Teslovich N, Rao DA, Ermann J, Jonsson AH, Navarrete C, Rich SS, Taylor KD, Rotter JI, Gregersen PK, Esko T, Brenner MB, Raychaudhuri S. Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci. Nat Genet. 2020 03; 52(3):247-253. PMID: 32066938.
  6. Dougados M, Wei JC, Landewé R, Sieper J, Baraliakos X, Van den Bosch F, Maksymowych WP, Ermann J, Walsh JA, Tomita T, Deodhar A, van der Heijde D, Li X, Zhao F, Bertram CC, Gallo G, Carlier H, Gensler LS. Efficacy and safety of ixekizumab through 52 weeks in two phase 3, randomised, controlled clinical trials in patients with active radiographic axial spondyloarthritis (COAST-V and COAST-W). Ann Rheum Dis. 2020 02; 79(2):176-185. PMID: 31685553.
  7. Zhao SS, Ermann J, Xu C, Lyu H, Tedeschi SK, Liao KP, Yoshida K, Moots RJ, Goodson NJ, Solomon DH. Comparison of comorbidities and treatment between ankylosing spondylitis and non-radiographic axial spondyloarthritis in the United States. Rheumatology (Oxford). 2019 11 01; 58(11):2025-2030. PMID: 31081033.
  8. Joyce AA, Williams JN, Shi J, Mandell JC, Isaac Z, Ermann J. Atlanto-axial Pannus in Patients with and without Rheumatoid Arthritis. J Rheumatol. 2019 11; 46(11):1431-1437. PMID: 30936276.
  9. Shi J, Ermann J, Weissman BN, Smith SE, Mandell JC. Thinking beyond pannus: a review of retro-odontoid pseudotumor due to rheumatoid and non-rheumatoid etiologies. Skeletal Radiol. 2019 Oct; 48(10):1511-1523. PMID: 30868232.
  10. Tsang K, Liu H, Yang Y, Charles JF, Ermann J. Defective circadian control in mesenchymal cells reduces adult bone mass in mice by promoting osteoclast function. Bone. 2019 04; 121:172-180. PMID: 30659979.
    Citations:    Fields:    
  11. Fonseka CY, Rao DA, Teslovich NC, Korsunsky I, Hannes SK, Slowikowski K, Gurish MF, Donlin LT, Lederer JA, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Todd DJ, Bykerk VP, Karlson EW, Ermann J, Lee YC, Brenner MB, Raychaudhuri S. Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis. Sci Transl Med. 2018 10 17; 10(463). PMID: 30333237.
    Citations:    Fields:    
  12. Ryzhakov G, West NR, Franchini F, Clare S, Ilott NE, Sansom SN, Bullers SJ, Pearson C, Costain A, Vaughan-Jackson A, Goettel JA, Ermann J, Horwitz BH, Buti L, Lu X, Mukhopadhyay S, Snapper SB, Powrie F. Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis. Nat Commun. 2018 09 18; 9(1):3797. PMID: 30228258.
    Citations:    Fields:    Translation:HumansAnimalsCells
  13. Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM. Author Correction: Towards an arthritis flare-responsive drug delivery system. Nat Commun. 2018 05 11; 9(1):1954. PMID: 29752435.
    Citations:    Fields:    
  14. Sun J, Ermann J, Niu N, Yan G, Yang Y, Shi Y, Zou W. Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Res. 2018; 6:14. PMID: 29707403.
  15. Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM. Towards an arthritis flare-responsive drug delivery system. Nat Commun. 2018 04 03; 9(1):1275. PMID: 29615615.
    Citations:    Fields:    Translation:HumansAnimalsCells
  16. Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB. Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification. Sci Transl Med. 2016 11 23; 8(366):366ra163. PMID: 27881824.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  17. Urso K, Alvarez D, Cremasco V, Tsang K, Grauel A, Lafyatis R, von Andrian UH, Ermann J, Aliprantis AO. IL4RA on lymphatic endothelial cells promotes T cell egress during sclerodermatous graft versus host disease. JCI Insight. 2016 Aug 04; 1(12). PMID: 27547823.
    Citations: 1     Fields:    
  18. Ermann J. Editorial: Of Mice and Mice: Understanding Conflicting Murine Experimental Data. Arthritis Rheumatol. 2016 08; 68(8):1801-4. PMID: 27059525.
    Citations:    Fields:    Translation:AnimalsCells
  19. Ge X, Tsang K, He L, Garcia RA, Ermann J, Mizoguchi F, Zhang M, Zhou B, Zhou B, Aliprantis AO. NFAT restricts osteochondroma formation from entheseal progenitors. JCI Insight. 2016 Apr; 1(4):e86254. PMID: 27158674.
    Citations: 2     Fields:    
  20. Ward MM, Deodhar A, Akl EA, Lui A, Ermann J, Gensler LS, Smith JA, Borenstein D, Hiratzka J, Weiss PF, Inman RD, Majithia V, Haroon N, Maksymowych WP, Joyce J, Clark BM, Colbert RA, Figgie MP, Hallegua DS, Prete PE, Rosenbaum JT, Stebulis JA, Van Den Bosch F, Yu DT, Miller AS, Reveille JD, Caplan L. American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis. Arthritis Care Res (Hoboken). 2016 Feb; 68(2):151-66. PMID: 26401907.
    Citations: 7     Fields:    Translation:Humans
  21. Ward MM, Deodhar A, Akl EA, Lui A, Ermann J, Gensler LS, Smith JA, Borenstein D, Hiratzka J, Weiss PF, Inman RD, Majithia V, Haroon N, Maksymowych WP, Joyce J, Clark BM, Colbert RA, Figgie MP, Hallegua DS, Prete PE, Rosenbaum JT, Stebulis JA, van den Bosch F, Yu DT, Miller AS, Reveille JD, Caplan L. American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis. Arthritis Rheumatol. 2016 Feb; 68(2):282-98. PMID: 26401991.
    Citations: 55     Fields:    Translation:Humans
  22. Cameron TL, Bell KM, Gresshoff IL, Sampurno L, Mullan L, Ermann J, Glimcher LH, Boot-Handford RP, Bateman JF. XBP1-Independent UPR Pathways Suppress C/EBP-ß Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease. PLoS Genet. 2015 Sep; 11(9):e1005505. PMID: 26372225.
    Citations: 4     Fields:    Translation:AnimalsCells
  23. Zhang S, Ermann J, Succi MD, Zhou A, Hamilton MJ, Cao B, Korzenik JR, Glickman JN, Vemula PK, Glimcher LH, Traverso G, Langer R, Karp JM. An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease. Sci Transl Med. 2015 Aug 12; 7(300):300ra128. PMID: 26268315.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  24. Ermann J, Rao DA, Teslovich NC, Brenner MB, Raychaudhuri S. Immune cell profiling to guide therapeutic decisions in rheumatic diseases. Nat Rev Rheumatol. 2015 Sep; 11(9):541-51. PMID: 26034835.
    Citations: 8     Fields:    Translation:HumansCells
  25. Charles JF, Ermann J, Aliprantis AO. The intestinal microbiome and skeletal fitness: Connecting bugs and bones. Clin Immunol. 2015 Aug; 159(2):163-9. PMID: 25840106.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  26. Cameron TL, Gresshoff IL, Bell KM, Piróg KA, Sampurno L, Hartley CL, Sanford EM, Wilson R, Ermann J, Boot-Handford RP, Glimcher LH, Briggs MD, Bateman JF. Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization. Osteoarthritis Cartilage. 2015 Apr; 23(4):661-70. PMID: 25600960.
    Citations: 8     Fields:    Translation:AnimalsCells
  27. Ermann J, Staton T, Glickman JN, de Waal Malefyt R, Glimcher LH. Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):E2559-66. PMID: 24927559.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  28. Ermann J, Glimcher LH. After GWAS: mice to the rescue? Curr Opin Immunol. 2012 Oct; 24(5):564-70. PMID: 23031443.
    Citations: 13     Fields:    Translation:HumansAnimals
  29. Ermann J, Garrett WS, Kuchroo J, Rourida K, Glickman JN, Bleich A, Glimcher LH. Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):7137-41. PMID: 21482794.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  30. Ermann J, Bermas BL. The biology behind the new therapies for SLE. Int J Clin Pract. 2007 Dec; 61(12):2113-9. PMID: 17997810.
    Citations: 8     Fields:    Translation:HumansCells
  31. Dutt S, Tseng D, Ermann J, George TI, Liu YP, Davis CR, Fathman CG, Strober S. Naive and memory T cells induce different types of graft-versus-host disease. J Immunol. 2007 Nov 15; 179(10):6547-54. PMID: 17982043.
    Citations: 27     Fields:    Translation:AnimalsCells
  32. Raychaudhuri S, Shmerling R, Ermann J, Helfgott S. Development of active tuberculosis following initiation of infliximab despite appropriate prophylaxis. Rheumatology (Oxford). 2007 May; 46(5):887-8. PMID: 17363399.
    Citations: 1     Fields:    Translation:Humans
  33. Dutt S, Ermann J, Tseng D, Liu YP, George TI, Fathman CG, Strober S. L-selectin and beta7 integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease. Blood. 2005 Dec 01; 106(12):4009-15. PMID: 16105972.
    Citations: 23     Fields:    Translation:AnimalsCells
  34. Hoffmann P, Ermann J, Edinger M. CD4+CD25+ regulatory T cells in hematopoietic stem cell transplantation. Curr Top Microbiol Immunol. 2005; 293:265-85. PMID: 15981484.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  35. Chan SM, Ermann J, Su L, Fathman CG, Utz PJ. Protein microarrays for multiplex analysis of signal transduction pathways. Nat Med. 2004 Dec; 10(12):1390-6. PMID: 15558056.
    Citations: 42     Fields:    Translation:HumansCells
  36. Ermann J, Hoffmann P, Edinger M, Dutt S, Blankenberg FG, Higgins JP, Negrin RS, Fathman CG, Strober S. Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood. 2005 Mar 01; 105(5):2220-6. PMID: 15546950.
    Citations: 120     Fields:    Translation:AnimalsCells
  37. Su L, Creusot RJ, Gallo EM, Chan SM, Utz PJ, Fathman CG, Ermann J. Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene. J Immunol. 2004 Oct 15; 173(8):4994-5001. PMID: 15470042.
    Citations: 15     Fields:    Translation:AnimalsCells
  38. Ermann J, Fathman CG. Costimulatory signals controlling regulatory T cells. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15292-3. PMID: 14676329.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  39. Ermann J, Chung CD, Fathman CG. Scratching the (T cell) surface. Genome Biol. 2003; 5(1):202. PMID: 14709166.
    Citations:    Fields:    Translation:HumansAnimalsCells
  40. Edinger M, Hoffmann P, Ermann J, Drago K, Fathman CG, Strober S, Negrin RS. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med. 2003 Sep; 9(9):1144-50. PMID: 12925844.
    Citations: 352     Fields:    Translation:AnimalsCells
  41. Tarner IH, Nakajima A, Seroogy CM, Ermann J, Levicnik A, Contag CH, Fathman CG. Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4. Clin Immunol. 2002 Dec; 105(3):304-14. PMID: 12498812.
    Citations: 11     Fields:    Translation:AnimalsCells
  42. Szanya V, Ermann J, Taylor C, Holness C, Fathman CG. The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J Immunol. 2002 Sep 01; 169(5):2461-5. PMID: 12193715.
    Citations: 90     Fields:    Translation:AnimalsCells
  43. Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med. 2002 Aug 05; 196(3):389-99. PMID: 12163567.
    Citations: 308     Fields:    Translation:AnimalsCells
  44. Ermann J, Szanya V, Ford GS, Paragas V, Fathman CG, Lejon K. CD4(+)CD25(+) T cells facilitate the induction of T cell anergy. J Immunol. 2001 Oct 15; 167(8):4271-5. PMID: 11591749.
    Citations: 32     Fields:    Translation:AnimalsCells
  45. Ermann J, Fathman CG. Autoimmune diseases: genes, bugs and failed regulation. Nat Immunol. 2001 Sep; 2(9):759-61. PMID: 11526377.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  46. Laub R, Dorsch M, Meyer D, Ermann J, Hedrich HJ, Emmrich F. A multiple transgenic mouse model with a partially humanized activation pathway for helper T cell responses. J Immunol Methods. 2000 Dec 01; 246(1-2):37-50. PMID: 11121545.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  47. Schädlich H, Ermann J, Biskop M, Falk W, Sperling F, Jüngel A, Lehmann J, Emmrich F, Sack U. Anti-inflammatory effects of systemic anti-tumour necrosis factor alpha treatment in human/murine SCID arthritis. Ann Rheum Dis. 1999 Jul; 58(7):428-34. PMID: 10381487.
    Citations: 2     Fields:    Translation:HumansAnimals
  48. Kuhn H, Ermann J, Sack U. Modulation of hu/mu severe combined immunodeficient (SCID) mouse arthritis by local application of human recombinant IL-1beta, IL-2 and IL-6. Clin Exp Immunol. 1997 Jan; 107(1):96-102. PMID: 9010263.
    Citations: 1     Fields:    Translation:HumansAnimals
  49. Sack U, Kuhn H, Ermann J, Kinne RW, Vogt S, Jungmichel D, Emmrich F. Synovial tissue implants from patients with rheumatoid arthritis cause cartilage destruction in knee joints of SCID.bg mice. J Rheumatol. 1994 Jan; 21(1):10-6. PMID: 8151561.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.