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Elisabetta Morini, Ph.D.

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Mentoring
Available: 01/01/19, Expires: 12/31/19

Familial dysautonomia (FD) is a recessive neurodegenerative disease caused by a splice mutation in the ELP1 gene that results in variable skipping of exon 20. The clinical features of FD are all due to a striking progressive depletion of sensory and autonomic neurons. Specifically, the aim of our research project is to study retinal degeneration in a new FD mouse model and to explore the therapeutic potential of a splice-targeted therapy. The student will be performing: • Mouse husbandry, genotyping and dissections. • Histological and immune-histochemical techniques. • Molecular and cellular biology techniques including DNA, RNA, and protein isolation and manipulation. Student's contribution and help to this project will be acknowledged in as co-authorship in subsequent publications.


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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Morini E, Catalano A, Lasco A, Morabito N, Benvenga S. Correction: In thyroxine-replaced hypothyroid postmenopausal women under simultaneous calcium supplementation, switch to oral liquid or softgel capsule L-thyroxine ensures lower serum TSH levels and favorable effects on blood pressure, total cholesterolemia and glycemia. Endocrine. 2019 Jun 28. PMID: 31254162.
    Citations:    
  2. Morini E, Catalano A, Lasco A, Morabito N, Benvenga S. In thyroxine-replaced hypothyroid postmenopausal women under simultaneous calcium supplementation, switch to oral liquid or softgel capsule L-thyroxine ensures lower serum TSH levels and favorable effects on blood pressure, total cholesterolemia and glycemia. Endocrine. 2019 Mar 27. PMID: 30919287.
    Citations:    
  3. Morini E, Gao D, Montgomery CM, Salani M, Mazzasette C, Krussig TA, Swain B, Dietrich P, Narasimhan J, Gabbeta V, Dakka A, Hedrick J, Zhao X, Weetall M, Naryshkin NA, Wojtkiewicz GG, Ko CP, Talkowski ME, Dragatsis I, Slaugenhaupt SA. ELP1 Splicing Correction Reverses Proprioceptive Sensory Loss in Familial Dysautonomia. Am J Hum Genet. 2019 Apr 04; 104(4):638-650. PMID: 30905397.
    Citations:    
  4. Portaro S, Morini E, Santoro ME, Accorinti M, Marzullo P, Naro A, Calabrò RS. Breathlessness in amyotrophic lateral sclerosis: A case report on the role of osteoporosis in the worsening of respiratory failure. Medicine (Baltimore). 2018 Nov; 97(45):e13026. PMID: 30407295.
    Citations:    
  5. Morini E, Catalano A, Lasco A, Morabito N, Benvenga S. L-thyroxine malabsorption due to calcium carbonate impairs blood pressure, total cholesterolemia, and fasting glycemia. Endocrine. 2019 May; 64(2):284-292. PMID: 30368654.
    Citations:    Fields:    
  6. Salani M, Urbina F, Brenner A, Morini E, Shetty R, Gallagher CS, Law EA, Sunshine S, Finneran DJ, Johnson G, Minor L, Slaugenhaupt SA. Development of a Screening Platform to Identify Small Molecules That Modify ELP1 Pre-mRNA Splicing in Familial Dysautonomia. SLAS Discov. 2019 Jan; 24(1):57-67. PMID: 30085848.
    Citations:    Fields:    
  7. Donadon I, Pinotti M, Rajkowska K, Pianigiani G, Barbon E, Morini E, Motaln H, Rogelj B, Mingozzi F, Slaugenhaupt SA, Pagani F. Exon-specific U1 snRNAs improve ELP1 exon 20 definition and rescue ELP1 protein expression in a familial dysautonomia mouse model. Hum Mol Genet. 2018 07 15; 27(14):2466-2476. PMID: 29701768.
    Citations: 1     Fields:    
  8. Catalano A, Gaudio A, Morabito N, Basile G, Agostino RM, Xourafa A, Atteritano M, Morini E, Natale G, Lasco A. Quantitative ultrasound and DXA measurements in aromatase inhibitor-treated breast cancer women receiving denosumab. J Endocrinol Invest. 2017 Aug; 40(8):851-857. PMID: 28332172.
    Citations: 1     Fields:    Translation:Humans
  9. Catalano A, Morabito N, Agostino RM, Basile G, Gaudio A, Atteritano M, Natale G, Xourafa A, Morini E, Adamo V, Lasco A. Bone health assessment by quantitative ultrasound and dual-energy x-ray absorptiometry in postmenopausal women with breast cancer receiving aromatase inhibitors. Menopause. 2017 01; 24(1):85-91. PMID: 27575547.
    Citations: 4     Fields:    Translation:Humans
  10. Morini E, Dietrich P, Salani M, Downs HM, Wojtkiewicz GR, Alli S, Brenner A, Nilbratt M, LeClair JW, Oaklander AL, Slaugenhaupt SA, Dragatsis I. Sensory and autonomic deficits in a new humanized mouse model of familial dysautonomia. Hum Mol Genet. 2016 Mar 15; 25(6):1116-28. PMID: 26769677.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  11. Lasco A, Morabito N, Basile G, Atteritano M, Gaudio A, Giorgianni GM, Morini E, Faraci B, Bellone F, Catalano A. Denosumab Inhibition of RANKL and Insulin Resistance in Postmenopausal Women with Osteoporosis. Calcif Tissue Int. 2016 Feb; 98(2):123-8. PMID: 26498169.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  12. Morabito N, Catalano A, Gaudio A, Morini E, Bruno LM, Basile G, Tsiantouli E, Bellone F, Agostino RM, Piraino B, La Rosa MA, Salpietro C, Lasco A. Effects of strontium ranelate on bone mass and bone turnover in women with thalassemia major-related osteoporosis. J Bone Miner Metab. 2016 Sep; 34(5):540-6. PMID: 26204844.
    Citations: 4     Fields:    Translation:Humans
  13. Catalano A, Morabito N, Di Stefano A, Morini E, Basile G, Faraci B, Loddo S, Ientile R, Lasco A. Vitamin D and bone mineral density changes in postmenopausal women treated with strontium ranelate. J Endocrinol Invest. 2015 Aug; 38(8):859-63. PMID: 25952299.
    Citations: 4     Fields:    Translation:Humans
  14. Sancisi V, Germinario E, Esposito A, Morini E, Peron S, Moggio M, Tomelleri G, Danieli-Betto D, Tupler R. Altered Tnnt3 characterizes selective weakness of fast fibers in mice overexpressing FSHD region gene 1 (FRG1). Am J Physiol Regul Integr Comp Physiol. 2014 Jan 15; 306(2):R124-37. PMID: 24305066.
    Citations: 11     Fields:    Translation:AnimalsCells
  15. Morabito N, Russo GT, Gaudio A, Lasco A, Catalano A, Morini E, Franchina F, Maisano D, La Rosa M, Plota M, Crifò A, Meo A, Frisina N. The "lively" cytokines network in beta-Thalassemia Major-related osteoporosis. Bone. 2007 Jun; 40(6):1588-94. PMID: 17412659.
    Citations: 15     Fields:    Translation:Humans
  16. Lasco A, Gaudio A, Morini E, Morabito N, Nicita-Mauro C, Catalano A, Denuzzo G, Sansotta C, Xourafa A, Macrì I, Frisina N. Effect of long-term treatment with raloxifene on mammary density in postmenopausal women. Menopause. 2006 Sep-Oct; 13(5):787-92. PMID: 16912660.
    Citations: 6     Fields:    Translation:Humans
  17. Lasco A, Morini E, Maglitto D, Campennì A, Benvenga S. Disappearance of a virilizing adrenal tumor following therapy with cyproterone acetate. Endocr Relat Cancer. 2005 Dec; 12(4):939-44. PMID: 16322333.
    Citations:    Fields:    Translation:Humans
  18. Zuccarello D, Morini E, Douzgou S, Ferlin A, Pizzuti A, Salpietro DC, Foresta C, Dallapiccola B. Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism. J Endocrinol Invest. 2004 Sep; 27(8):760-4. PMID: 15636430.
    Citations: 3     Fields:    Translation:Humans
  19. Sarkozy A, Conti E, Digilio MC, Marino B, Morini E, Pacileo G, Wilson M, Calabrò R, Pizzuti A, Dallapiccola B. Clinical and molecular analysis of 30 patients with multiple lentigines LEOPARD syndrome. J Med Genet. 2004 May; 41(5):e68. PMID: 15121796.
    Citations: 26     Fields:    Translation:HumansCells
  20. Trifiletti A, Lasco A, Scamardi R, Pizzoleo MA, Gaudio A, La Rocca R, Morini E, Frisina N. Long-term hemostatic effects of cholesterol-lowering therapy with atorvastatin. Pathophysiol Haemost Thromb. 2003 Mar-Apr; 33(2):84-7. PMID: 14624049.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  21. Lasco A, Frisina N, Morabito N, Gaudio A, Morini E, Trifiletti A, Basile G, Nicita-Mauro V, Cucinotta D. Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women. Eur J Endocrinol. 2001 Oct; 145(4):457-61. PMID: 11581005.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.