Harvard Catalyst Profiles

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Kevin Hodgetts, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. U01AG066759 (HODGETTS, KEVIN) Jun 15, 2021 - May 31, 2025
    NIH
    Discovery of Drugs that Modulate Neuroinflammation for the treatment of Alzheimer's Disease
    Role: Principal Investigator
  2. U01AG071495 (HODGETTS, KEVIN) Jun 1, 2021 - May 31, 2024
    NIH
    Optimization and evaluation of novel benzimidazoles for the treatment of Alzheimer's Disease
    Role: Principal Investigator
  3. R33NS095139 (ANDROPHY, ELLIOT J) Feb 1, 2018 - Jan 31, 2021
    NIH
    Optimization of Compounds that Stabilize the SMN Protein for Treatment of SMA
    Role: Co-Principal Investigator
  4. R56AG051638 (ABRAHAM, CARMELA R) Sep 15, 2016 - Aug 31, 2018
    NIH
    Discovery of probes that enhance expression of the neuroprotective protein Klotho
    Role: Co-Principal Investigator
  5. R21NS095139 (ANDROPHY, ELLIOT J) Jan 1, 2016 - Dec 31, 2017
    NIH
    Optimization of Compounds that Stabilize the SMN Protein for Treatment of SMA
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sanmarco LM, Chao CC, Wang YC, Kenison JE, Li Z, Rone JM, Rejano-Gordillo CM, Polonio CM, Gutierrez-Vazquez C, Piester G, Plasencia A, Li L, Giovannoni F, Lee HG, Faust Akl C, Wheeler MA, Mascanfroni I, Jaronen M, Alsuwailm M, Hewson P, Yeste A, Andersen BM, Franks DG, Huang CJ, Ekwudo M, Tjon EC, Rothhammer V, Takenaka M, de Lima KA, Linnerbauer M, Guo L, Covacu R, Queva H, Fonseca-Castro PH, Bladi MA, Cox LM, Hodgetts KJ, Hahn ME, Mildner A, Korzenik J, Hauser R, Snapper SB, Quintana FJ. Identification of environmental factors that promote intestinal inflammation. Nature. 2022 11; 611(7937):801-809. PMID: 36266581; PMCID: PMC9898826.
    Citations: 5     Fields:    Translation:AnimalsCells
  2. Fanning S, Cirka H, Thies JL, Jeong J, Niemi SM, Yoon J, Ho GPH, Pacheco JA, Dettmer U, Liu L, Clish CB, Hodgetts KJ, Hutchinson JN, Muratore CR, Caldwell GA, Caldwell KA, Selkoe D. Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy. NPJ Parkinsons Dis. 2022 Jun 09; 8(1):74. PMID: 35680956; PMCID: PMC9184586.
    Citations:    
  3. Saha T, Mondal J, Khiste S, Lusic H, Hu ZW, Jayabalan R, Hodgetts KJ, Jang H, Sengupta S, Eunice Lee S, Park Y, Lee LP, Goldman A. Nanotherapeutic approaches to overcome distinct drug resistance barriers in models of breast cancer. Nanophotonics. 2021 Sep; 10(12):3063-3073. PMID: 34589378.
    Citations: 2     
  4. Clark IC, Gutiérrez-Vázquez C, Wheeler MA, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao CC, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Manganeli Polonio C, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, Alves de Lima K, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ. Barcoded viral tracing of single-cell interactions in central nervous system inflammation. Science. 2021 04 23; 372(6540). PMID: 33888612; PMCID: PMC8157482.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  5. Rietz A, Hodgetts KJ, Lusic H, Quist KM, Osman EY, Lorson CL, Androphy EJ. Short-duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy. Life Sci Alliance. 2021 01; 4(1). PMID: 33234679.
    Citations:    Fields:    Translation:AnimalsCells
  6. Nuber S, Nam AY, Rajsombath MM, Cirka H, Hronowski X, Wang J, Hodgetts K, Kalinichenko LS, Müller CP, Lambrecht V, Winkler J, Weihofen A, Imberdis T, Dettmer U, Fanning S, Selkoe DJ. A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in a-Synuclein Mice. Ann Neurol. 2021 01; 89(1):74-90. PMID: 32996158.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  7. Wang X, Xu Z, Zhao F, Lin KJ, Foster JB, Xiao T, Kung N, Askwith CC, Bruno JP, Valentini V, Hodgetts KJ, Lin CG. Restoring tripartite glutamatergic synapses: A potential therapy for mood and cognitive deficits in Gulf War illness. Neurobiol Stress. 2020 Nov; 13:100240. PMID: 33344696.
    Citations: 5     
  8. Foster JB, Lashley R, Zhao F, Wang X, Kung N, Askwith CC, Lin L, Shultis MW, Hodgetts KJ, Lin CG. Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer's disease: a preclinical study in rTg4510 mice. Alzheimers Res Ther. 2019 08 23; 11(1):75. PMID: 31439023; PMCID: PMC6706914.
    Citations: 6     Fields:    Translation:AnimalsCells
  9. Osman EY, Rietz A, Kline RA, Cherry JJ, Hodgetts KJ, Lorson CL, Androphy EJ. Intraperitoneal delivery of a novel drug-like compound improves disease severity in severe and intermediate mouse models of Spinal Muscular Atrophy. Sci Rep. 2019 02 07; 9(1):1633. PMID: 30733501.
    Citations: 6     Fields:    Translation:AnimalsCells
  10. Foster JB, Zhao F, Wang X, Xu Z, Lin K, Askwith CC, Hodgetts KJ, Lin CG. Pyridazine-derivatives Enhance Structural and Functional Plasticity of Tripartite Synapse Via Activation of Local Translation in Astrocytic Processes. Neuroscience. 2018 09 15; 388:224-238. PMID: 30056115; PMCID: PMC6667176.
    Citations: 8     Fields:    Translation:AnimalsCells
  11. Choi S, Calder AN, Miller EH, Anderson KP, Fiejtek DK, Rietz A, Li H, Cherry JJ, Quist KM, Xing X, Glicksman MA, Cuny GD, Lorson CL, Androphy EA, Hodgetts KJ. Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers. Bioorg Med Chem Lett. 2017 12 01; 27(23):5144-5148. PMID: 29103974.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Rietz A, Li H, Quist KM, Cherry JJ, Lorson CL, Burnett BG, Kern NL, Calder AN, Fritsche M, Lusic H, Boaler PJ, Choi S, Xing X, Glicksman MA, Cuny GD, Androphy EJ, Hodgetts KJ. Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy. J Med Chem. 2017 06 08; 60(11):4594-4610. PMID: 28481536.
    Citations: 4     Fields:    Translation:HumansCells
  13. Calder AN, Androphy EJ, Hodgetts KJ. Small Molecules in Development for the Treatment of Spinal Muscular Atrophy. J Med Chem. 2016 11 23; 59(22):10067-10083. PMID: 27490705; PMCID: PMC5744254.
    Citations: 27     Fields:    Translation:HumansCells
  14. Takahashi K, Kong Q, Lin Y, Stouffer N, Schulte DA, Lai L, Liu Q, Chang LC, Dominguez S, Xing X, Cuny GD, Hodgetts KJ, Glicksman MA, Lin CL. Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease. J Exp Med. 2015 Mar 09; 212(3):319-32. PMID: 25711212; PMCID: PMC4354363.
    Citations: 51     Fields:    Translation:AnimalsCells
  15. Hodgetts KJ, Ge P, Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Kieltyka A, Horvath RF, Kehne JH, Krause JE, Maynard GD, Hoffman D, Lee Y, Fung L, Doller D. Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist. J Med Chem. 2011 Jun 23; 54(12):4187-206. PMID: 21618986.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  16. Hodgetts KJ, Blum CA, Caldwell T, Bakthavatchalam R, Zheng X, Capitosti S, Krause JE, Cortright D, Crandall M, Murphy BA, Boyce S, Brian Jones A, Chenard BL. Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites. Bioorg Med Chem Lett. 2010 Aug 01; 20(15):4359-63. PMID: 20615696.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  17. Blum CA, Caldwell T, Zheng X, Bakthavatchalam R, Capitosti S, Brielmann H, De Lombaert S, Kershaw MT, Matson D, Krause JE, Cortright D, Crandall M, Martin WJ, Murphy BA, Boyce S, Jones AB, Mason G, Rycroft W, Perrett H, Conley R, Burnaby-Davies N, Chenard BL, Hodgetts KJ. Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists. J Med Chem. 2010 Apr 22; 53(8):3330-48. PMID: 20307063.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  18. Guo Q, Chandrasekhar J, Ihle D, Wustrow DJ, Chenard BL, Krause JE, Hutchison A, Alderman D, Cheng C, Cortright D, Broom D, Kershaw MT, Simmermacher-Mayer J, Peng Y, Hodgetts KJ. 1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists. Bioorg Med Chem Lett. 2008 Sep 15; 18(18):5027-31. PMID: 18752949.
    Citations: 1     Fields:    Translation:AnimalsCells
  19. Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Krause JE, Hutchison A, Horvath RF, Ge P, Kehne J, Hoffman D, Chandrasekhar J, Doller D, Hodgetts KJ. 2-Arylpyrimidines: novel CRF-1 receptor antagonists. Bioorg Med Chem Lett. 2008 Aug 15; 18(16):4486-90. PMID: 18672365.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  20. Blum CA, Zheng X, Brielmann H, Hodgetts KJ, Bakthavatchalam R, Chandrasekhar J, Krause JE, Cortright D, Matson D, Crandall M, Ngo CK, Fung L, Day M, Kershaw M, De Lombaert S, Chenard BL. Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution. Bioorg Med Chem Lett. 2008 Aug 15; 18(16):4573-7. PMID: 18662872.
    Citations: 2     Fields:    Translation:AnimalsCells
  21. Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Chandrasekhar J, Horvath RF, Ge P, Kershaw MT, Krause JE, Kehne J, Hoffman D, Doller D, Hodgetts KJ. The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists. Bioorg Med Chem Lett. 2008 Feb 01; 18(3):891-6. PMID: 18180159.
    Citations: 3     Fields:    Translation:HumansCells
  22. Zheng X, Hodgetts KJ, Brielmann H, Hutchison A, Burkamp F, Brian Jones A, Blurton P, Clarkson R, Chandrasekhar J, Bakthavatchalam R, De Lombaert S, Crandall M, Cortright D, Blum CA. From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist. Bioorg Med Chem Lett. 2006 Oct 01; 16(19):5217-21. PMID: 16870426.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  23. Hodgetts KJ, Kershaw MT. Synthesis of 2-aryl-oxazolo[4,5-c]quinoline-4(5H)-ones and 2-aryl-thiazolo[4,5-c]quinoline-4(5H)-ones. Org Lett. 2003 Aug 07; 5(16):2911-4. PMID: 12889906.
    Citations: 2     Fields:    
  24. Hodgetts KJ, Yoon T, Huang J, Gulianello M, Kieltyka A, Primus R, Brodbeck R, De Lombaert S, Doller D. 2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel crf-1 receptor antagonists. Bioorg Med Chem Lett. 2003 Aug 04; 13(15):2497-500. PMID: 12852951.
    Citations: 1     Fields:    Translation:HumansCells
  25. Zhao H, Zhang X, Hodgetts K, Thurkauf A, Hammer J, Chandrasekhar J, Kieltyka A, Brodbeck R, Rachwal S, Primus R, Manly C. Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist. Bioorg Med Chem Lett. 2003 Feb 24; 13(4):701-4. PMID: 12639562.
    Citations:    Fields:    Translation:HumansCells
  26. Zhao H, Thurkauf A, He X, Hodgetts K, Zhang X, Rachwal S, Kover RX, Hutchison A, Peterson J, Kieltyka A, Brodbeck R, Primus R, Wasley JW. Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships. Bioorg Med Chem Lett. 2002 Nov 04; 12(21):3105-9. PMID: 12372512.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  27. Hodgetts KJ, Kershaw MT. Ethyl 2-chlorooxazole-4-carboxylate: a versatile intermediate for the synthesis of substituted oxazoles. Org Lett. 2002 Aug 22; 4(17):2905-7. PMID: 12182585.
    Citations: 7     Fields:    
  28. Yuan J, Gulianello M, De Lombaert S, Brodbeck R, Kieltyka A, Hodgetts KJ. 3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists. Bioorg Med Chem Lett. 2002 Aug 19; 12(16):2133-6. PMID: 12127521.
    Citations: 3     Fields:    Translation:Cells
  29. Hodgetts KJ, Kershaw MT. Regiocontrolled synthesis of substituted thiazoles. Org Lett. 2002 Apr 18; 4(8):1363-5. PMID: 11950363.
    Citations: 1     Fields:    Translation:Cells
  30. Hodgetts KJ, Kieltyka A, Brodbeck R, Tran JN, Wasley JW, Thurkauf A. 6-(4-Benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D(4) receptors. Bioorg Med Chem. 2001 Dec; 9(12):3207-13. PMID: 11711296.
    Citations: 2     Fields:    Translation:AnimalsCells
  31. Zhang X, Hodgetts K, Rachwal S, Zhao H, Wasley JW, Craven K, Brodbeck R, Kieltyka A, Hoffman D, Bacolod MD, Girard B, Tran J, Thurkauf A. trans-1-[(2-Phenylcyclopropyl)methyl]-4-arylpiperazines: mixed dopamine D(2)/D(4) receptor antagonists as potential antipsychotic agents. J Med Chem. 2000 Oct 19; 43(21):3923-32. PMID: 11052797.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  32. Bolitho DG, Boustred M, Hudson DA, Hodgetts K. Primary epineural repair of the ulnar nerve in children. J Hand Surg Am. 1999 Jan; 24(1):16-20. PMID: 10048511.
    Citations: 8     Fields:    Translation:Humans
  33. Hudson DA, Bolitho DG, Hodgetts K. Primary epineural repair of the median nerve in children. J Hand Surg Br. 1997 Feb; 22(1):54-6. PMID: 9061526.
    Citations: 5     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.