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Ryo Hotta, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nagy N, Guyer RA, Hotta R, Zhang D, Newgreen DF, Halasy V, Kovacs T, Goldstein AM. RET overactivation leads to concurrent Hirschsprung disease and intestinal ganglioneuromas. Development. 2020 Sep 29. PMID: 32994173.
  2. Shimada H, Lee S, Bae S, Hotta R. A New Life Satisfaction Scale Predicts Depressive Symptoms in a National Cohort of Older Japanese Adults. Front Psychiatry. 2020; 11:625. PMID: 32765309.
  3. Egami H, Hotta R, Otsubo M, Rouno T, Niwa T, Yamashita K, Hamashima Y. Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst. Org Lett. 2020 07 17; 22(14):5656-5660. PMID: 32608984.
  4. Bhave S, Arciero E, Baker C, Ho WL, Guyer RA, Hotta R, Goldstein AM. Pan-enteric neuropathy and dysmotility are present in a mouse model of short-segment Hirschsprung disease and may contribute to post-pullthrough morbidity. J Pediatr Surg. 2020 Apr 17. PMID: 32414519.
  5. Bhave S, Arciero E, Baker C, Ho WL, Stavely R, Goldstein AM, Hotta R. Enteric neuronal cell therapy reverses architectural changes in a novel diphtheria toxin-mediated model of colonic aganglionosis. Sci Rep. 2019 12 10; 9(1):18756. PMID: 31822721.
  6. Baker C, Ahmed M, Cheng K, Arciero E, Bhave S, Ho WLN, Goldstein AM, Hotta R. Hypoganglionosis in the gastric antrum causes delayed gastric emptying. Neurogastroenterol Motil. 2020 05; 32(5):e13766. PMID: 31773831.
  7. Jaroy EG, Acosta-Jimenez L, Hotta R, Goldstein AM, Emblem R, Klungland A, Ougland R. "Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review. Clin Epigenetics. 2019 09 13; 11(1):135. PMID: 31519213.
  8. Doi T, Tsutsumimoto K, Nakakubo S, Kim MJ, Kurita S, Hotta R, Shimada H. Physical Performance Predictors for Incident Dementia Among Japanese Community-Dwelling Older Adults. Phys Ther. 2019 09 01; 99(9):1132-1140. PMID: 31162614.
  9. Nakakubo S, Doi T, Makizako H, Tsutsumimoto K, Hotta R, Kurita S, Kim M, Suzuki T, Shimada H. Sleep condition and cognitive decline in Japanese community-dwelling older people: Data from a 4-year longitudinal study. J Sleep Res. 2019 08; 28(4):e12803. PMID: 30537088.
    Citations:    Fields:    
  10. Kurita S, Doi T, Tsutsumimoto K, Hotta R, Nakakubo S, Kim M, Shimada H. Cognitive activity in a sitting position is protectively associated with cognitive impairment among older adults. Geriatr Gerontol Int. 2019 Feb; 19(2):98-102. PMID: 30276939.
    Citations:    Fields:    
  11. Doi T, Makizako H, Tsutsumimoto K, Nakakubo S, Kim MJ, Kurita S, Hotta R, Shimada H. Transitional status and modifiable risk of frailty in Japanese older adults: A prospective cohort study. Geriatr Gerontol Int. 2018 Nov; 18(11):1562-1566. PMID: 30225955.
    Citations:    Fields:    
  12. Nakakubo S, Doi T, Makizako H, Tsutsumimoto K, Hotta R, Kurita S, Kim M, Suzuki T, Shimada H. Association of walk ratio during normal gait speed and fall in community-dwelling elderly people. Gait Posture. 2018 10; 66:151-154. PMID: 30195217.
    Citations:    Fields:    
  13. Tsutsumimoto K, Doi T, Makizako H, Hotta R, Nakakubo S, Makino K, Suzuki T, Shimada H. Aging-related anorexia and its association with disability and frailty. J Cachexia Sarcopenia Muscle. 2018 10; 9(5):834-843. PMID: 30109778.
    Citations: 1     Fields:    
  14. Dora D, Arciero E, Hotta R, Barad C, Bhave S, Kovacs T, Balic A, Goldstein AM, Nagy N. Intraganglionic macrophages: a new population of cells in the enteric ganglia. J Anat. 2018 10; 233(4):401-410. PMID: 30022489.
    Citations:    Fields:    
  15. Doi T, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Makino K, Suzuki T, Shimada H. Combined effects of mild cognitive impairment and slow gait on risk of dementia. Exp Gerontol. 2018 09; 110:146-150. PMID: 29879449.
    Citations:    Fields:    
  16. Nagy N, Barad C, Hotta R, Bhave S, Arciero E, Dora D, Goldstein AM. Collagen 18 and agrin are secreted by neural crest cells to remodel their microenvironment and regulate their migration during enteric nervous system development. Development. 2018 05 08; 145(9). PMID: 29678817.
    Citations: 2     Fields:    Translation:AnimalsCells
  17. Tsutsumimoto K, Doi T, Makizako H, Hotta R, Nakakubo S, Makino K, Suzuki T, Shimada H. Cognitive Frailty is Associated with Fall-Related Fracture among Older People. J Nutr Health Aging. 2018; 22(10):1216-1220. PMID: 30498829.
    Citations:    Fields:    
  18. Nakakubo S, Makizako H, Doi T, Tsutsumimoto K, Hotta R, Lee S, Lee S, Bae S, Makino K, Suzuki T, Shimada H. Long and Short Sleep Duration and Physical Frailty in Community-Dwelling Older Adults. J Nutr Health Aging. 2018; 22(9):1066-1071. PMID: 30379304.
    Citations:    Fields:    
  19. Belkind-Gerson J, Graham HK, Reynolds J, Hotta R, Nagy N, Cheng L, Kamionek M, Shi HN, Aherne CM, Goldstein AM. Colitis promotes neuronal differentiation of Sox2+ and PLP1+ enteric cells. Sci Rep. 2017 05 31; 7(1):2525. PMID: 28566702.
  20. Cheng LS, Hotta R, Graham HK, Belkind-Gerson J, Nagy N, Goldstein AM. Postnatal human enteric neuronal progenitors can migrate, differentiate, and proliferate in embryonic and postnatal aganglionic gut environments. Pediatr Res. 2017 May; 81(5):838-846. PMID: 28060794.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  21. Cheng LS, Graham HK, Pan WH, Nagy N, Carreon-Rodriguez A, Goldstein AM, Hotta R. Optimizing neurogenic potential of enteric neurospheres for treatment of neurointestinal diseases. J Surg Res. 2016 12; 206(2):451-459. PMID: 27884342.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  22. Cheng LS, Schwartz DM, Hotta R, Graham HK, Goldstein AM. Bowel dysfunction following pullthrough surgery is associated with an overabundance of nitrergic neurons in Hirschsprung disease. J Pediatr Surg. 2016 Nov; 51(11):1834-1838. PMID: 27570241.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  23. Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schäfer KH, Metzger M, Hotta R, Young HM, Andrews PW, Thapar N, Belkind-Gerson J, Bondurand N, Bornstein JC, Chan WY, Cheah K, Gershon MD, Heuckeroth RO, Hofstra RM, Just L, Kapur RP, King SK, McCann CJ, Nagy N, Ngan E, Obermayr F, Pachnis V, Pasricha PJ, Sham MH, Tam P, Vanden Berghe P. White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Dev Biol. 2016 09 15; 417(2):229-51. PMID: 27059883.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  24. Hotta R, Cheng L, Graham HK, Nagy N, Belkind-Gerson J, Mattheolabakis G, Amiji MM, Goldstein AM. Delivery of enteric neural progenitors with 5-HT4 agonist-loaded nanoparticles and thermosensitive hydrogel enhances cell proliferation and differentiation following transplantation in vivo. Biomaterials. 2016 May; 88:1-11. PMID: 26922325.
    Citations: 5     Fields:    Translation:AnimalsCells
  25. Belkind-Gerson J, Hotta R, Whalen M, Nayyar N, Nagy N, Cheng L, Zuckerman A, Goldstein AM, Dietrich J. Engraftment of enteric neural progenitor cells into the injured adult brain. BMC Neurosci. 2016 Jan 25; 17:5. PMID: 26810757.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  26. Hotta R, Cheng LS, Graham HK, Pan W, Nagy N, Belkind-Gerson J, Goldstein AM. Isogenic enteric neural progenitor cells can replace missing neurons and glia in mice with Hirschsprung disease. Neurogastroenterol Motil. 2016 Apr; 28(4):498-512. PMID: 26685978.
    Citations: 9     Fields:    Translation:AnimalsCells
  27. Nagy N, Barad C, Graham HK, Hotta R, Cheng LS, Fejszak N, Goldstein AM. Sonic hedgehog controls enteric nervous system development by patterning the extracellular matrix. Development. 2016 Jan 15; 143(2):264-75. PMID: 26674309.
    Citations: 9     Fields:    Translation:AnimalsCells
  28. Cheng LS, Hotta R, Graham HK, Nagy N, Goldstein AM, Belkind-Gerson J. Endoscopic delivery of enteric neural stem cells to treat Hirschsprung disease. Neurogastroenterol Motil. 2015 Oct; 27(10):1509-14. PMID: 26190543.
    Citations: 2     Fields:    Translation:AnimalsCells
  29. Belkind-Gerson J, Hotta R, Nagy N, Thomas AR, Graham H, Cheng L, Solorzano J, Nguyen D, Kamionek M, Dietrich J, Cherayil BJ, Goldstein AM. Colitis induces enteric neurogenesis through a 5-HT4-dependent mechanism. Inflamm Bowel Dis. 2015 Apr; 21(4):870-8. PMID: 25742399.
    Citations: 13     Fields:    Translation:AnimalsCells
  30. Hotta R, Fujimura T, Shimojima N, Nakahara T, Fuchimoto Y, Hoshino K, Morikawa Y, Matsufuji H, Kuroda T. Application of nuclear medicine to achieve less invasive surgery for malignant solid tumors in children. Pediatr Int. 2014 Dec; 56(6):896-901. PMID: 24773623.
    Citations:    Fields:    Translation:Humans
  31. Nishikawa R, Hotta R, Shimojima N, Shibata S, Nagoshi N, Nakamura M, Matsuzaki Y, Okano HJ, Kuroda T, Okano H, Morikawa Y. Migration and differentiation of transplanted enteric neural crest-derived cells in murine model of Hirschsprung's disease. Cytotechnology. 2015 Aug; 67(4):661-70. PMID: 25230796.
    Citations: 6     Fields:    
  32. Akbareian SE, Nagy N, Steiger CE, Mably JD, Miller SA, Hotta R, Molnar D, Goldstein AM. Enteric neural crest-derived cells promote their migration by modifying their microenvironment through tenascin-C production. Dev Biol. 2013 Oct 15; 382(2):446-56. PMID: 23958436.
    Citations: 12     Fields:    Translation:Animals
  33. Hotta R, Stamp LA, Foong JP, McConnell SN, Bergner AJ, Anderson RB, Enomoto H, Newgreen DF, Obermayr F, Furness JB, Young HM. Transplanted progenitors generate functional enteric neurons in the postnatal colon. J Clin Invest. 2013 Mar; 123(3):1182-91. PMID: 23454768.
    Citations: 38     Fields:    Translation:AnimalsCells
  34. Obermayr F, Hotta R, Enomoto H, Young HM. Development and developmental disorders of the enteric nervous system. Nat Rev Gastroenterol Hepatol. 2013 Jan; 10(1):43-57. PMID: 23229326.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  35. Hotta R, Thapar N. Advances in enteric neurobiology: how close are we to clinical use? J Pediatr Gastroenterol Nutr. 2011 Dec; 53 Suppl 2:S43-5. PMID: 22235473.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  36. Hotta R, Natarajan D, Burns AJ, Thapar N. Stem cells for GI motility disorders. Curr Opin Pharmacol. 2011 Dec; 11(6):617-23. PMID: 22056114.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  37. Hotta R, Pepdjonovic L, Anderson RB, Zhang D, Bergner AJ, Leung J, Pébay A, Young HM, Newgreen DF, Dottori M. Small-molecule induction of neural crest-like cells derived from human neural progenitors. Stem Cells. 2009 Dec; 27(12):2896-905. PMID: 19711454.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  38. Hotta R, Natarajan D, Thapar N. Potential of cell therapy to treat pediatric motility disorders. Semin Pediatr Surg. 2009 Nov; 18(4):263-73. PMID: 19782309.
    Citations: 12     Fields:    Translation:HumansAnimals
  39. Hotta R, Anderson RB, Kobayashi K, Newgreen DF, Young HM. Effects of tissue age, presence of neurones and endothelin-3 on the ability of enteric neurone precursors to colonize recipient gut: implications for cell-based therapies. Neurogastroenterol Motil. 2010 Mar; 22(3):331-e86. PMID: 19775251.
    Citations: 17     Fields:    Translation:AnimalsCells
  40. Hotta R, Hoshino K, Nakatsuka S, Nakao S, Okamura J, Yamada Y, Komori K, Fuchimoto Y, Obara H, Kawachi S, Tanabe M, Morikawa Y, Hashimoto S, Kitajima M. Transileocolic venous balloon dilatation for the management of primary and recurrent portal venous stenosis after living donor liver transplantation in children. Pediatr Surg Int. 2007 Oct; 23(10):939-45. PMID: 17661062.
    Citations: 2     Fields:    Translation:Humans
  41. Yamada Y, Hoshino K, Morikawa Y, Okamura J, Hotta R, Komori K, Nakao S, Obara H, Kawachi S, Fuchimoto Y, Tanabe M, Shimazu M, Kitajima M. Successful liver transplantation across the ABO incompatibility barrier in 6 cases of biliary atresia. J Pediatr Surg. 2006 Dec; 41(12):1976-9. PMID: 17161185.
    Citations: 4     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.