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Ryo Hotta, Ph.D.

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Jikei University School of Medicine, Tokyo, JapanMD03/1999Medicine
University of Melbourne, Melbourne, AustraliaPhD12/2011Anatomy and Cell Biology


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03HD104877 (HOTTA, RYO) Apr 15, 2021 - Mar 31, 2023
    Regulation of Experimental Colitis by Enteric Neurons
    Role: Principal Investigator
  2. R03HD100762 (HOTTA, RYO) Dec 1, 2020 - Nov 30, 2022
    Autologous cell transplantation for the treatment of colorectal aganglionosis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Stavely R, Hotta R, Picard N, Rahman AA, Pan W, Bhave S, Omer M, Ho WLN, Guyer RA, Goldstein AM. Schwann cells in the subcutaneous adipose tissue have neurogenic potential and can be used for regenerative therapies. Sci Transl Med. 2022 05 25; 14(646):eabl8753. PMID: 35613280.
    Citations:    Fields:    Translation:AnimalsCells
  2. Bhave S, Ho WLN, Cheng K, Omer M, Bousquet N, Guyer RA, Hotta R, Goldstein AM. Tamoxifen administration alters gastrointestinal motility in mice. Neurogastroenterol Motil. 2022 05; 34(5):e14357. PMID: 35279902.
    Citations:    Fields:    Translation:Animals
  3. Nagy N, Kovacs T, Stavely R, Halasy V, Soos A, Szocs E, Hotta R, Graham H, Goldstein AM. Avian ceca are indispensable for hindgut enteric nervous system development. Development. 2021 11 15; 148(22). PMID: 34792104; PMCID: PMC8645208.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Pan W, Goldstein AM, Hotta R. Opportunities for novel diagnostic and cell-based therapies for Hirschsprung disease. J Pediatr Surg. 2022 Sep; 57(9):61-68. PMID: 34852916; PMCID: PMC9068833.
    Citations: 1     Fields:    
  5. Dora D, Ferenczi S, Stavely R, Toth VE, Varga ZV, Kovacs T, Bodi I, Hotta R, Kovacs KJ, Goldstein AM, Nagy N. Evidence of a Myenteric Plexus Barrier and Its Macrophage-Dependent Degradation During Murine Colitis: Implications in Enteric Neuroinflammation. Cell Mol Gastroenterol Hepatol. 2021; 12(5):1617-1641. PMID: 34246810; PMCID: PMC8551790.
    Citations: 4     Fields:    Translation:AnimalsCells
  6. Inlender T, Nissim-Eliraz E, Stavely R, Hotta R, Goldstein AM, Yagel S, Gutnick MJ, Shpigel NY. Homeostasis of mucosal glial cells in human gut is independent of microbiota. Sci Rep. 2021 06 17; 11(1):12796. PMID: 34140608.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Stavely R, Bhave S, Ho WLN, Ahmed M, Pan W, Rahman AA, Ulloa J, Bousquet N, Omer M, Guyer R, Nagy N, Goldstein AM, Hotta R. Enteric mesenchymal cells support the growth of postnatal enteric neural stem cells. Stem Cells. 2021 09; 39(9):1236-1252. PMID: 33938072.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Nagy N, Guyer RA, Hotta R, Zhang D, Newgreen DF, Halasy V, Kovacs T, Goldstein AM. RET overactivation leads to concurrent Hirschsprung disease and intestinal ganglioneuromas. Development. 2020 11 05; 147(21). PMID: 32994173; PMCID: PMC7657479.
    Citations: 3     Fields:    Translation:AnimalsCells
  9. Bhave S, Arciero E, Baker C, Ho WL, Guyer RA, Hotta R, Goldstein AM. Pan-enteric neuropathy and dysmotility are present in a mouse model of short-segment Hirschsprung disease and may contribute to post-pullthrough morbidity. J Pediatr Surg. 2021 Feb; 56(2):250-256. PMID: 32414519; PMCID: PMC7572464.
    Citations: 2     Fields:    Translation:HumansAnimals
  10. Bhave S, Arciero E, Baker C, Ho WL, Stavely R, Goldstein AM, Hotta R. Enteric neuronal cell therapy reverses architectural changes in a novel diphtheria toxin-mediated model of colonic aganglionosis. Sci Rep. 2019 12 10; 9(1):18756. PMID: 31822721.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  11. Baker C, Ahmed M, Cheng K, Arciero E, Bhave S, Ho WLN, Goldstein AM, Hotta R. Hypoganglionosis in the gastric antrum causes delayed gastric emptying. Neurogastroenterol Motil. 2020 05; 32(5):e13766. PMID: 31773831.
    Citations: 1     Fields:    Translation:AnimalsCells
  12. Jaroy EG, Acosta-Jimenez L, Hotta R, Goldstein AM, Emblem R, Klungland A, Ougland R. "Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review. Clin Epigenetics. 2019 09 13; 11(1):135. PMID: 31519213; PMCID: PMC6743154.
    Citations: 13     Fields:    Translation:HumansCells
  13. Dora D, Arciero E, Hotta R, Barad C, Bhave S, Kovacs T, Balic A, Goldstein AM, Nagy N. Intraganglionic macrophages: a new population of cells in the enteric ganglia. J Anat. 2018 10; 233(4):401-410. PMID: 30022489.
    Citations: 4     Fields:    Translation:AnimalsCells
  14. Nagy N, Barad C, Hotta R, Bhave S, Arciero E, Dora D, Goldstein AM. Collagen 18 and agrin are secreted by neural crest cells to remodel their microenvironment and regulate their migration during enteric nervous system development. Development. 2018 05 08; 145(9). PMID: 29678817.
    Citations: 19     Fields:    Translation:AnimalsCells
  15. Belkind-Gerson J, Graham HK, Reynolds J, Hotta R, Nagy N, Cheng L, Kamionek M, Shi HN, Aherne CM, Goldstein AM. Colitis promotes neuronal differentiation of Sox2+ and PLP1+ enteric cells. Sci Rep. 2017 05 31; 7(1):2525. PMID: 28566702; PMCID: PMC5451421.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  16. Cheng LS, Hotta R, Graham HK, Belkind-Gerson J, Nagy N, Goldstein AM. Postnatal human enteric neuronal progenitors can migrate, differentiate, and proliferate in embryonic and postnatal aganglionic gut environments. Pediatr Res. 2017 May; 81(5):838-846. PMID: 28060794; PMCID: PMC5769482.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  17. Cheng LS, Graham HK, Pan WH, Nagy N, Carreon-Rodriguez A, Goldstein AM, Hotta R. Optimizing neurogenic potential of enteric neurospheres for treatment of neurointestinal diseases. J Surg Res. 2016 12; 206(2):451-459. PMID: 27884342; PMCID: PMC5125510.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  18. Cheng LS, Schwartz DM, Hotta R, Graham HK, Goldstein AM. Bowel dysfunction following pullthrough surgery is associated with an overabundance of nitrergic neurons in Hirschsprung disease. J Pediatr Surg. 2016 Nov; 51(11):1834-1838. PMID: 27570241; PMCID: PMC5065396.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  19. Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schäfer KH, Metzger M, Hotta R, Young HM, Andrews PW, Thapar N, Belkind-Gerson J, Bondurand N, Bornstein JC, Chan WY, Cheah K, Gershon MD, Heuckeroth RO, Hofstra RM, Just L, Kapur RP, King SK, McCann CJ, Nagy N, Ngan E, Obermayr F, Pachnis V, Pasricha PJ, Sham MH, Tam P, Vanden Berghe P. White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Dev Biol. 2016 09 15; 417(2):229-51. PMID: 27059883; PMCID: PMC5026875.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  20. Hotta R, Cheng L, Graham HK, Nagy N, Belkind-Gerson J, Mattheolabakis G, Amiji MM, Goldstein AM. Delivery of enteric neural progenitors with 5-HT4 agonist-loaded nanoparticles and thermosensitive hydrogel enhances cell proliferation and differentiation following transplantation in vivo. Biomaterials. 2016 May; 88:1-11. PMID: 26922325; PMCID: PMC4792702.
    Citations: 11     Fields:    Translation:AnimalsCells
  21. Belkind-Gerson J, Hotta R, Whalen M, Nayyar N, Nagy N, Cheng L, Zuckerman A, Goldstein AM, Dietrich J. Engraftment of enteric neural progenitor cells into the injured adult brain. BMC Neurosci. 2016 Jan 25; 17:5. PMID: 26810757.
    Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
  22. Hotta R, Cheng LS, Graham HK, Pan W, Nagy N, Belkind-Gerson J, Goldstein AM. Isogenic enteric neural progenitor cells can replace missing neurons and glia in mice with Hirschsprung disease. Neurogastroenterol Motil. 2016 Apr; 28(4):498-512. PMID: 26685978; PMCID: PMC4808355.
    Citations: 16     Fields:    Translation:AnimalsCells
  23. Nagy N, Barad C, Graham HK, Hotta R, Cheng LS, Fejszak N, Goldstein AM. Sonic hedgehog controls enteric nervous system development by patterning the extracellular matrix. Development. 2016 Jan 15; 143(2):264-75. PMID: 26674309; PMCID: PMC4725345.
    Citations: 25     Fields:    Translation:AnimalsCells
  24. Cheng LS, Hotta R, Graham HK, Nagy N, Goldstein AM, Belkind-Gerson J. Endoscopic delivery of enteric neural stem cells to treat Hirschsprung disease. Neurogastroenterol Motil. 2015 Oct; 27(10):1509-14. PMID: 26190543; PMCID: PMC4600089.
    Citations: 7     Fields:    Translation:AnimalsCells
  25. Belkind-Gerson J, Hotta R, Nagy N, Thomas AR, Graham H, Cheng L, Solorzano J, Nguyen D, Kamionek M, Dietrich J, Cherayil BJ, Goldstein AM. Colitis induces enteric neurogenesis through a 5-HT4-dependent mechanism. Inflamm Bowel Dis. 2015 Apr; 21(4):870-8. PMID: 25742399; PMCID: PMC6688165.
    Citations: 33     Fields:    Translation:AnimalsCells
  26. Hotta R, Fujimura T, Shimojima N, Nakahara T, Fuchimoto Y, Hoshino K, Morikawa Y, Matsufuji H, Kuroda T. Application of nuclear medicine to achieve less invasive surgery for malignant solid tumors in children. Pediatr Int. 2014 Dec; 56(6):896-901. PMID: 24773623.
    Citations:    Fields:    Translation:Humans
  27. Nishikawa R, Hotta R, Shimojima N, Shibata S, Nagoshi N, Nakamura M, Matsuzaki Y, Okano HJ, Kuroda T, Okano H, Morikawa Y. Migration and differentiation of transplanted enteric neural crest-derived cells in murine model of Hirschsprung's disease. Cytotechnology. 2015 Aug; 67(4):661-70. PMID: 25230796.
    Citations: 8     Fields:    
  28. Akbareian SE, Nagy N, Steiger CE, Mably JD, Miller SA, Hotta R, Molnar D, Goldstein AM. Enteric neural crest-derived cells promote their migration by modifying their microenvironment through tenascin-C production. Dev Biol. 2013 Oct 15; 382(2):446-56. PMID: 23958436.
    Citations: 29     Fields:    Translation:Animals
  29. Hotta R, Stamp LA, Foong JP, McConnell SN, Bergner AJ, Anderson RB, Enomoto H, Newgreen DF, Obermayr F, Furness JB, Young HM. Transplanted progenitors generate functional enteric neurons in the postnatal colon. J Clin Invest. 2013 Mar; 123(3):1182-91. PMID: 23454768; PMCID: PMC3582137.
    Citations: 66     Fields:    Translation:AnimalsCells
  30. Obermayr F, Hotta R, Enomoto H, Young HM. Development and developmental disorders of the enteric nervous system. Nat Rev Gastroenterol Hepatol. 2013 Jan; 10(1):43-57. PMID: 23229326.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  31. Hotta R, Thapar N. Advances in enteric neurobiology: how close are we to clinical use? J Pediatr Gastroenterol Nutr. 2011 Dec; 53 Suppl 2:S43-5. PMID: 22235473.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  32. Hotta R, Natarajan D, Burns AJ, Thapar N. Stem cells for GI motility disorders. Curr Opin Pharmacol. 2011 Dec; 11(6):617-23. PMID: 22056114.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  33. Hotta R, Pepdjonovic L, Anderson RB, Zhang D, Bergner AJ, Leung J, Pébay A, Young HM, Newgreen DF, Dottori M. Small-molecule induction of neural crest-like cells derived from human neural progenitors. Stem Cells. 2009 Dec; 27(12):2896-905. PMID: 19711454.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  34. Hotta R, Natarajan D, Thapar N. Potential of cell therapy to treat pediatric motility disorders. Semin Pediatr Surg. 2009 Nov; 18(4):263-73. PMID: 19782309.
    Citations: 16     Fields:    Translation:HumansAnimals
  35. Hotta R, Anderson RB, Kobayashi K, Newgreen DF, Young HM. Effects of tissue age, presence of neurones and endothelin-3 on the ability of enteric neurone precursors to colonize recipient gut: implications for cell-based therapies. Neurogastroenterol Motil. 2010 Mar; 22(3):331-e86. PMID: 19775251.
    Citations: 20     Fields:    Translation:AnimalsCells
  36. Hotta R, Hoshino K, Nakatsuka S, Nakao S, Okamura J, Yamada Y, Komori K, Fuchimoto Y, Obara H, Kawachi S, Tanabe M, Morikawa Y, Hashimoto S, Kitajima M. Transileocolic venous balloon dilatation for the management of primary and recurrent portal venous stenosis after living donor liver transplantation in children. Pediatr Surg Int. 2007 Oct; 23(10):939-45. PMID: 17661062.
    Citations: 4     Fields:    Translation:Humans
  37. Yamada Y, Hoshino K, Morikawa Y, Okamura J, Hotta R, Komori K, Nakao S, Obara H, Kawachi S, Fuchimoto Y, Tanabe M, Shimazu M, Kitajima M. Successful liver transplantation across the ABO incompatibility barrier in 6 cases of biliary atresia. J Pediatr Surg. 2006 Dec; 41(12):1976-9. PMID: 17161185.
    Citations: 6     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.