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Venkat Giri Magupalli, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, Lieberman J, Ruan J, Wu H. Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. 2021 Apr 21. PMID: 33883744.
    Citations:    Fields:    
  2. Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 2020 09 18; 369(6510). PMID: 32943500.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  3. Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol. 2020 07; 21(7):736-745. PMID: 32367036.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  4. Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Núñez G, Mao Y, Wu H. Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature. 2019 06; 570(7761):338-343. PMID: 31189953.
    Citations: 63     Fields:    Translation:HumansCells
  5. Zhang P, Fan Y, Ru H, Wang L, Magupalli VG, Taylor SS, Alessi DR, Wu H. Crystal structure of the WD40 domain dimer of LRRK2. Proc Natl Acad Sci U S A. 2019 01 29; 116(5):1579-1584. PMID: 30635421.
    Citations: 9     Fields:    Translation:HumansCells
  6. Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 2016 07 07; 535(7610):153-8. PMID: 27383986.
    Citations: 439     Fields:    Translation:HumansAnimalsCells
  7. Wahl S, Magupalli VG, Dembla M, Katiyar R, Schwarz K, Köblitz L, Alpadi K, Krause E, Rettig J, Sung CH, Goldberg AF, Schmitz F. The Disease Protein Tulp1 Is Essential for Periactive Zone Endocytosis in Photoreceptor Ribbon Synapses. J Neurosci. 2016 Feb 24; 36(8):2473-93. PMID: 26911694.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Yan J, Leal K, Magupalli VG, Nanou E, Martinez GQ, Scheuer T, Catterall WA. Modulation of CaV2.1 channels by neuronal calcium sensor-1 induces short-term synaptic facilitation. Mol Cell Neurosci. 2014 Nov; 63:124-31. PMID: 25447945.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  9. Kagan JC, Magupalli VG, Wu H. SMOCs: supramolecular organizing centres that control innate immunity. Nat Rev Immunol. 2014 12; 14(12):821-6. PMID: 25359439.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  10. Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell. 2014 Mar 13; 156(6):1193-1206. PMID: 24630722.
    Citations: 342     Fields:    Translation:HumansCells
  11. Lu A, Kabaleeswaran V, Fu T, Magupalli VG, Wu H. Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions. J Mol Biol. 2014 Apr 03; 426(7):1420-7. PMID: 24406744.
    Citations: 18     Fields:    Translation:HumansCells
  12. Magupalli VG, Mochida S, Yan J, Jiang X, Westenbroek RE, Nairn AC, Scheuer T, Catterall WA. Ca2+-independent activation of Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain of CaV2.1 calcium channels. J Biol Chem. 2013 Feb 15; 288(7):4637-48. PMID: 23255606.
    Citations: 10     Fields:    Translation:HumansCells
  13. Venkatesan JK, Natarajan S, Schwarz K, Mayer SI, Alpadi K, Magupalli VG, Sung CH, Schmitz F. Nicotinamide adenine dinucleotide-dependent binding of the neuronal Ca2+ sensor protein GCAP2 to photoreceptor synaptic ribbons. J Neurosci. 2010 May 12; 30(19):6559-76. PMID: 20463219.
    Citations: 15     Fields:    Translation:AnimalsCells
  14. Magupalli VG, Schwarz K, Alpadi K, Natarajan S, Seigel GM, Schmitz F. Multiple RIBEYE-RIBEYE interactions create a dynamic scaffold for the formation of synaptic ribbons. J Neurosci. 2008 Aug 06; 28(32):7954-67. PMID: 18685021.
    Citations: 52     Fields:    Translation:AnimalsCells
  15. Alpadi K, Magupalli VG, Käppel S, Köblitz L, Schwarz K, Seigel GM, Sung CH, Schmitz F. RIBEYE recruits Munc119, a mammalian ortholog of the Caenorhabditis elegans protein unc119, to synaptic ribbons of photoreceptor synapses. J Biol Chem. 2008 Sep 26; 283(39):26461-7. PMID: 18664567.
    Citations: 27     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.