Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

David Clapham, M.D., Ph.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
completed student projects
External Calcium Modulates TRPC5 Activity
Summer, 06/20/05 - 08/15/05
A Study of Transient Receptor Channels (trp) in C Elegans
Summer, 05/20/99 - 09/01/99
Characterization of human STIM and Orai, putative regulators of cytosolic calcium signaling
Full Time, 09/15/06 - 03/30/07

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R56DK103739 (CLAPHAM, DAVID E.) Sep 1, 2015 - Aug 31, 2016
    NIH/NIDDK
    Direct measurement of polycystin channels and their regulation in cilia
    Role: Principal Investigator
  2. R01MH105851 (BOLSHAKOV, VADIM) Jul 1, 2015 - Mar 31, 2021
    NIH
    TRPC-mediated control of anxiety
    Role: Co-Principal Investigator
  3. P01NS072040 (CLAPHAM, DAVID E.) Aug 1, 2011 - May 31, 2017
    NIH
    TRP Channel Mediated Pain Circuitry
    Role: Co-Principal Investigator
  4. R01MH090293 (CLAPHAM, DAVID E.) Mar 15, 2010 - Dec 31, 2014
    NIH/NIMH
    Canonical Transient Receptor Potential (TRPC) subfamily function in Hippocampus.
    Role: Principal Investigator
  5. U01HD045857 (CLAPHAM, DAVID E.) Jan 30, 2004 - Jan 31, 2014
    NIH/NICHD
    CarSpers:sperm-specific ion channels;targets for male contraceptives
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Clapham DE, Hulse RE. Sperm CatSper ion channel swims into sharper focus. Nature. 2021 Jul; 595(7869):654-655. PMID: 34290412.
    Citations:    Fields:    
  2. Bernal L, Sotelo-Hitschfeld P, König C, Sinica V, Wyatt A, Winter Z, Hein A, Touska F, Reinhardt S, Tragl A, Kusuda R, Wartenberg P, Sclaroff A, Pfeifer JD, Ectors F, Dahl A, Freichel M, Vlachova V, Brauchi S, Roza C, Boehm U, Clapham DE, Lennerz JK, Zimmermann K. Odontoblast TRPC5 channels signal cold pain in teeth. Sci Adv. 2021 Mar; 7(13). PMID: 33771873.
    Citations: 2     Fields:    
  3. Liu B, Mundt N, Miller M, Clapham DE, Kirichok Y, Lishko PV. Recording Electrical Currents across the Plasma Membrane of Mammalian Sperm Cells. J Vis Exp. 2021 02 14; (168). PMID: 33645583.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Gao S, Valinsky WC, On NC, Houlihan PR, Qu Q, Liu L, Pan X, Clapham DE, Yan N. Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+ channels in nanodisc. Proc Natl Acad Sci U S A. 2020 06 23; 117(25):14187-14193. PMID: 32513729.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  5. Deo C, Sheu SH, Seo J, Clapham DE, Lavis LD. Isomeric Tuning Yields Bright and Targetable Red Ca2+ Indicators. J Am Chem Soc. 2019 09 04; 141(35):13734-13738. PMID: 31430138.
    Citations: 11     Fields:    
  6. Duan J, Li J, Chen GL, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y, Xu J, Xue C, Liang B, Zhu L, Liu W, Zhang C, Tian XL, Wang J, Clapham DE, Zeng B, Li Z, Zhang J. Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function. Sci Adv. 2019 07; 5(7):eaaw7935. PMID: 31355338.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  7. Duan J, Li Z, Li J, Hulse RE, Santa-Cruz A, Valinsky WC, Abiria SA, Krapivinsky G, Zhang J, Clapham DE. Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):E8201-E8210. PMID: 30108148.
    Citations: 28     Fields:    Translation:AnimalsCells
  8. Duan J, Li J, Zeng B, Chen GL, Peng X, Zhang Y, Wang J, Clapham DE, Li Z, Zhang J. Structure of the mouse TRPC4 ion channel. Nat Commun. 2018 08 06; 9(1):3102. PMID: 30082700.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  9. Hulse RE, Li Z, Huang RK, Zhang J, Clapham DE. Cryo-EM structure of the polycystin 2-l1 ion channel. Elife. 2018 07 13; 7. PMID: 30004384.
    Citations: 17     Fields:    Translation:HumansCells
  10. Clapham DE. Influences: Short circuits. J Gen Physiol. 2018 04 02; 150(4):513-515. PMID: 29559507.
    Citations: 1     Fields:    
  11. Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J, Clapham DE. Structure of full-length human TRPM4. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):2377-2382. PMID: 29463718.
    Citations: 27     Fields:    Translation:Humans
  12. Liu X, Vien T, Duan J, Sheu SH, DeCaen PG, Clapham DE. Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium. Elife. 2018 02 14; 7. PMID: 29443690.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  13. Krapivinsky G, Krapivinsky L, Renthal NE, Santa-Cruz A, Manasian Y, Clapham DE. Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression. Proc Natl Acad Sci U S A. 2017 08 22; 114(34):E7092-E7100. PMID: 28784805.
    Citations: 8     Fields:    Translation:HumansCells
  14. Abiria SA, Krapivinsky G, Sah R, Santa-Cruz AG, Chaudhuri D, Zhang J, Adstamongkonkul P, DeCaen PG, Clapham DE. TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):E6079-E6088. PMID: 28696294.
    Citations: 24     Fields:    Translation:HumansCells
  15. Chung JJ, Miki K, Kim D, Shim SH, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, Clapham DE. CatSper? regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. Elife. 2017 02 23; 6. PMID: 28226241.
    Citations: 40     Fields:    Translation:AnimalsCells
  16. Platt CD, Chou J, Houlihan P, Badran YR, Kumar L, Bainter W, Poliani PL, Perez CJ, Dent SYR, Clapham DE, Benavides F, Geha RS. Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function. J Allergy Clin Immunol. 2017 Dec; 140(6):1651-1659.e1. PMID: 28192143.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  17. Pablo JL, DeCaen PG, Clapham DE. Progress in ciliary ion channel physiology. J Gen Physiol. 2017 Jan; 149(1):37-47. PMID: 27999145.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  18. Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E. The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell. 2016 Oct 20; 167(3):763-773.e11. PMID: 27768895.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  19. DeCaen PG, Liu X, Abiria S, Clapham DE. Atypical calcium regulation of the PKD2-L1 polycystin ion channel. Elife. 2016 06 27; 5. PMID: 27348301.
    Citations: 22     Fields:    Translation:HumansCells
  20. Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE. Primary cilia are not calcium-responsive mechanosensors. Nature. 2016 Mar 31; 531(7596):656-60. PMID: 27007841.
    Citations: 117     Fields:    Translation:AnimalsCells
  21. Chaudhuri D, Artiga DJ, Abiria SA, Clapham DE. Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):E1872-80. PMID: 26976564.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  22. Naylor CE, Bagnéris C, DeCaen PG, Sula A, Scaglione A, Clapham DE, Wallace BA. Molecular basis of ion permeability in a voltage-gated sodium channel. EMBO J. 2016 Apr 15; 35(8):820-30. PMID: 26873592.
    Citations: 32     Fields:    Translation:HumansCells
  23. Blair NT, Philipson BI, Richards PM, Doerner JF, Segura A, Silver WL, Clapham DE. Naturally Produced Defensive Alkenal Compounds Activate TRPA1. Chem Senses. 2016 05; 41(4):281-92. PMID: 26843529.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  24. Syeda SS, Carlson EJ, Miller MR, Francis R, Clapham DE, Lishko PV, Hawkinson JE, Hook D, Georg GI. The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex. ACS Chem Biol. 2016 Feb 19; 11(2):452-9. PMID: 26674547.
    Citations:    Fields:    Translation:HumansAnimalsCells
  25. Doerner JF, Delling M, Clapham DE. Ion channels and calcium signaling in motile cilia. Elife. 2015 Dec 09; 4. PMID: 26650848.
    Citations: 12     Fields:    
  26. Clapham DE. Structural biology: Pain-sensing TRPA1 channel resolved. Nature. 2015 Apr 23; 520(7548):439-41. PMID: 25855290.
    Citations: 1     Fields:    Translation:Humans
  27. Cai X, Wang X, Patel S, Clapham DE. Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view. Cell Calcium. 2015 Mar; 57(3):166-73. PMID: 25498309.
    Citations: 16     Fields:    Translation:AnimalsCells
  28. DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE. Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus. Elife. 2014 Nov 11; 3. PMID: 25385530.
    Citations: 14     Fields:    Translation:Cells
  29. Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D. Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. Neurosurgery. 2014 Aug; 61 Suppl 1:214. PMID: 25032616.
    Citations:    
  30. Cai X, Wang X, Clapham DE. Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex. Mol Biol Evol. 2014 Oct; 31(10):2735-40. PMID: 25063443.
    Citations: 18     Fields:    Translation:AnimalsCells
  31. Krapivinsky G, Krapivinsky L, Manasian Y, Clapham DE. The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase. Cell. 2014 May 22; 157(5):1061-72. PMID: 24855944.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  32. Bagnéris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA. Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8428-33. PMID: 24850863.
    Citations: 51     Fields:    Translation:HumansCells
  33. Chung JJ, Shim SH, Everley RA, Gygi SP, Zhuang X, Clapham DE. Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell. 2014 May 08; 157(4):808-22. PMID: 24813608.
    Citations: 66     Fields:    Translation:AnimalsCells
  34. Kahle KT, Khanna A, Clapham DE, Woolf CJ. Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain. JAMA Neurol. 2014 May; 71(5):640-5. PMID: 24615367.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  35. Chaudhuri D, Clapham DE. Outstanding questions regarding the permeation, selectivity, and regulation of the mitochondrial calcium uniporter. Biochem Biophys Res Commun. 2014 Jul 11; 449(4):367-9. PMID: 24792175.
    Citations: 3     Fields:    Translation:HumansCells
  36. Py BF, Jin M, Desai BN, Penumaka A, Zhu H, Kober M, Dietrich A, Lipinski MM, Henry T, Clapham DE, Yuan J. Caspase-11 controls interleukin-1ß release through degradation of TRPC1. Cell Rep. 2014 Mar 27; 6(6):1122-1128. PMID: 24630989.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  37. Riccio A, Li Y, Tsvetkov E, Gapon S, Yao GL, Smith KS, Engin E, Rudolph U, Bolshakov VY, Clapham DE. Decreased anxiety-like behavior and Gaq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. J Neurosci. 2014 Mar 05; 34(10):3653-67. PMID: 24599464.
    Citations: 37     Fields:    Translation:AnimalsCells
  38. Tsai MF, Jiang D, Zhao L, Clapham D, Miller C. Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1. J Gen Physiol. 2014 Jan; 143(1):67-73. PMID: 24344246.
    Citations: 48     Fields:    Translation:Humans
  39. Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12; 504(7479):311-4. PMID: 24336288.
    Citations: 201     Fields:    Translation:HumansAnimalsCells
  40. DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12; 504(7479):315-8. PMID: 24336289.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  41. Carvacho I, Lee HC, Fissore RA, Clapham DE. TRPV3 channels mediate strontium-induced mouse-egg activation. Cell Rep. 2013 Dec 12; 5(5):1375-86. PMID: 24316078.
    Citations: 25     Fields:    Translation:AnimalsCells
  42. Clapham DE. The mother of all endocytosis. Elife. 2013 Nov 26; 2:e01738. PMID: 24282238.
    Citations: 2     Fields:    Translation:AnimalsCells
  43. Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK. EMRE is an essential component of the mitochondrial calcium uniporter complex. Science. 2013 Dec 13; 342(6164):1379-82. PMID: 24231807.
    Citations: 245     Fields:    Translation:HumansCells
  44. Clapham DE. Sperm BerserKers. Elife. 2013 Oct 08; 2:e01469. PMID: 24137547.
    Citations: 4     Fields:    Translation:HumansCells
  45. Zeng XH, Navarro B, Xia XM, Clapham DE, Lingle CJ. Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. J Gen Physiol. 2013 Sep; 142(3):305-13. PMID: 23980198.
    Citations: 22     Fields:    Translation:AnimalsCells
  46. Sah R, Mesirca P, Van den Boogert M, Rosen J, Mably J, Mangoni ME, Clapham DE. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):E3037-46. PMID: 23878236.
    Citations: 45     Fields:    Translation:AnimalsCells
  47. Mesirca P, Marger L, Toyoda F, Rizzetto R, Audoubert M, Dubel S, Torrente AG, Difrancesco ML, Muller JC, Leoni AL, Couette B, Nargeot J, Clapham DE, Wickman K, Mangoni ME. The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. J Gen Physiol. 2013 Aug; 142(2):113-26. PMID: 23858001.
    Citations: 25     Fields:    Translation:AnimalsCells
  48. Chaudhuri D, Sancak Y, Mootha VK, Clapham DE. MCU encodes the pore conducting mitochondrial calcium currents. Elife. 2013 Jun 04; 2:e00704. PMID: 23755363.
    Citations: 82     Fields:    Translation:HumansCells
  49. Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation. 2013 Jul 09; 128(2):101-14. PMID: 23734001.
    Citations: 44     Fields:    Translation:AnimalsCells
  50. Jiang D, Zhao L, Clish CB, Clapham DE. Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2249-54. PMID: 23716663.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  51. Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6364-9. PMID: 23542377.
    Citations: 62     Fields:    Translation:HumansCells
  52. Miki K, Clapham DE. Rheotaxis guides mammalian sperm. Curr Biol. 2013 Mar 18; 23(6):443-52. PMID: 23453951.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  53. Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell. 2013 Feb 14; 152(4):778-790. PMID: 23394946.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  54. Bagnéris C, Decaen PG, Hall BA, Naylor CE, Clapham DE, Kay CW, Wallace BA. Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nat Commun. 2013; 4:2465. PMID: 24051986.
    Citations: 37     Fields:    Translation:Cells
  55. Lishko P, Clapham DE, Navarro B, Kirichok Y. Sperm patch-clamp. Methods Enzymol. 2013; 525:59-83. PMID: 23522465.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  56. Zhang X, Xia M, Li Y, Liu H, Jiang X, Ren W, Wu J, DeCaen P, Yu F, Huang S, He J, Clapham DE, Yan N, Gong H. Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh. Cell Res. 2013 Mar; 23(3):409-22. PMID: 23247626.
    Citations: 19     Fields:    Translation:AnimalsCells
  57. Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 2012 Oct 12; 151(2):372-83. PMID: 23063126.
    Citations: 191     Fields:    Translation:AnimalsCells
  58. Stotz SC, Clapham DE. Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. PLoS One. 2012; 7(10):e46865. PMID: 23056495.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  59. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28; 151(1):96-110. PMID: 23021218.
    Citations: 126     Fields:    Translation:AnimalsCells
  60. Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell. 2012 Jun 12; 22(6):1149-62. PMID: 22698280.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  61. Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham DE, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 2012 May 20; 486(7401):130-4. PMID: 22678295.
    Citations: 212     Fields: