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profileDavid Clapham, M.D., PH.D.

TitleAldo R. Castaneda Professor of Cardiovascular Research
InstitutionBoston Children's Hospital
DepartmentNeurobiology
AddressCardiovascular Research
Enders 1309
320 Longwood Ave
Boston MA 02115
Phone617/919-2680
Fax617/731-0787
vCardDownload vCard (login for email)
Other Positions
TitleAldo R. Castaneda Professor of Cardiovascular Research
InstitutionBoston Children's Hospital
DepartmentPediatrics


Collapse Mentoring 
Collapse completed student projects
External Calcium Modulates TRPC5 Activity
Summer, 06/20/05 - 08/15/05
A Study of Transient Receptor Channels (trp) in C Elegans
Summer, 05/20/99 - 09/01/99
Characterization of human STIM and Orai, putative regulators of cytosolic calcium signaling
Full Time, 09/15/06 - 03/30/07

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R56DK103739     (CLAPHAM, DAVID E.)Sep 1, 2015 - Aug 31, 2016
NIH/NIDDK
Direct measurement of polycystin channels and their regulation in cilia
Role: Principal Investigator

R01MH105851     (BOLSHAKOV, VADIM)Jul 1, 2015 - Mar 31, 2020
NIH/NIMH
TRPC-mediated control of anxiety
Role: Co-Principal Investigator

P01NS072040     (CLAPHAM, DAVID E.)Aug 1, 2011 - Jul 31, 2016
NIH/NINDS
TRP Channel Mediated Pain Circuitry
Role: Co-Principal Investigator

R01MH090293     (CLAPHAM, DAVID E.)Mar 15, 2010 - Dec 31, 2014
NIH/NIMH
Canonical Transient Receptor Potential (TRPC) subfamily function in Hippocampus.
Role: Principal Investigator

U01HD045857     (CLAPHAM, DAVID E.)Jan 30, 2004 - Jan 31, 2014
NIH/NICHD
CarSpers:sperm-specific ion channels;targets for male contraceptives
Role: Principal Investigator
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This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Clapham Lab - Mouse strains (30)

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Krapivinsky G, Krapivinsky L, Renthal NE, Santa-Cruz A, Manasian Y, Clapham DE. Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression. Proc Natl Acad Sci U S A. 2017 Aug 22; 114(34):E7092-E7100. PMID: 28784805.
    View in: PubMed
  2. Abiria SA, Krapivinsky G, Sah R, Santa-Cruz AG, Chaudhuri D, Zhang J, Adstamongkonkul P, DeCaen PG, Clapham DE. TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles. Proc Natl Acad Sci U S A. 2017 Jul 25; 114(30):E6079-E6088. PMID: 28696294.
    View in: PubMed
  3. Chung JJ, Miki K, Kim D, Shim SH, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, Clapham DE. CatSper? regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. Elife. 2017 Feb 23; 6. PMID: 28226241.
    View in: PubMed
  4. Platt CD, Chou J, Houlihan P, Badran YR, Kumar L, Bainter W, Poliani PL, Perez CJ, Dent SY, Clapham DE, Benavides F, Geha RS. Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function. J Allergy Clin Immunol. 2017 Feb 10. PMID: 28192143.
    View in: PubMed
  5. Pablo JL, DeCaen PG, Clapham DE. Progress in ciliary ion channel physiology. J Gen Physiol. 2017 Jan; 149(1):37-47. PMID: 27999145.
    View in: PubMed
  6. Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E. The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell. 2016 Oct 20; 167(3):763-773.e11. PMID: 27768895.
    View in: PubMed
  7. DeCaen PG, Liu X, Abiria S, Clapham DE. Atypical calcium regulation of the PKD2-L1 polycystin ion channel. Elife. 2016 Jun 27; 5. PMID: 27348301; PMCID: PMC4922860.
  8. Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE. Primary cilia are not calcium-responsive mechanosensors. Nature. 2016 Mar 31; 531(7596):656-60. PMID: 27007841; PMCID: PMC4851444.
  9. Chaudhuri D, Artiga DJ, Abiria SA, Clapham DE. Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):E1872-80. PMID: 26976564; PMCID: PMC4822583.
  10. Naylor CE, Bagnéris C, DeCaen PG, Sula A, Scaglione A, Clapham DE, Wallace BA. Molecular basis of ion permeability in a voltage-gated sodium channel. EMBO J. 2016 Apr 15; 35(8):820-30. PMID: 26873592; PMCID: PMC4972137 [Available on 04/15/17].
  11. Blair NT, Philipson BI, Richards PM, Doerner JF, Segura A, Silver WL, Clapham DE. Naturally Produced Defensive Alkenal Compounds Activate TRPA1. Chem Senses. 2016 05; 41(4):281-92. PMID: 26843529.
    View in: PubMed
  12. Syeda SS, Carlson EJ, Miller MR, Francis R, Clapham DE, Lishko PV, Hawkinson JE, Hook D, Georg GI. The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex. ACS Chem Biol. 2016 Feb 19; 11(2):452-9. PMID: 26674547; PMCID: PMC4761407.
  13. Doerner JF, Delling M, Clapham DE. Ion channels and calcium signaling in motile cilia. Elife. 2015 Dec 09; 4. PMID: 26650848.
    View in: PubMed
  14. Clapham DE. Structural biology: Pain-sensing TRPA1 channel resolved. Nature. 2015 Apr 23; 520(7548):439-41. PMID: 25855290.
    View in: PubMed
  15. Cai X, Wang X, Patel S, Clapham DE. Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view. Cell Calcium. 2015 Mar; 57(3):166-73. PMID: 25498309; PMCID: PMC4355082.
  16. DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE. Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus. Elife. 2014 Nov 11; 3. PMID: 25385530; PMCID: PMC4225499.
  17. Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D. Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. Neurosurgery. 2014 Aug; 61 Suppl 1:214. PMID: 25032616.
    View in: PubMed
  18. Cai X, Wang X, Clapham DE. Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex. Mol Biol Evol. 2014 Oct; 31(10):2735-40. PMID: 25063443; PMCID: PMC4169769.
  19. Krapivinsky G, Krapivinsky L, Manasian Y, Clapham DE. The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase. Cell. 2014 May 22; 157(5):1061-72. PMID: 24855944; PMCID: PMC4156102.
  20. Bagnéris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA. Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8428-33. PMID: 24850863; PMCID: PMC4060673.
  21. Chung JJ, Shim SH, Everley RA, Gygi SP, Zhuang X, Clapham DE. Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell. 2014 May 08; 157(4):808-22. PMID: 24813608; PMCID: PMC4032590.
  22. Kahle KT, Khanna A, Clapham DE, Woolf CJ. Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain. JAMA Neurol. 2014 May; 71(5):640-5. PMID: 24615367; PMCID: PMC4465580.
  23. Chaudhuri D, Clapham DE. Outstanding questions regarding the permeation, selectivity, and regulation of the mitochondrial calcium uniporter. Biochem Biophys Res Commun. 2014 Jul 11; 449(4):367-9. PMID: 24792175.
    View in: PubMed
  24. Py BF, Jin M, Desai BN, Penumaka A, Zhu H, Kober M, Dietrich A, Lipinski MM, Henry T, Clapham DE, Yuan J. Caspase-11 controls interleukin-1ß release through degradation of TRPC1. Cell Rep. 2014 Mar 27; 6(6):1122-8. PMID: 24630989; PMCID: PMC4239700.
  25. Riccio A, Li Y, Tsvetkov E, Gapon S, Yao GL, Smith KS, Engin E, Rudolph U, Bolshakov VY, Clapham DE. Decreased anxiety-like behavior and Gaq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. J Neurosci. 2014 Mar 05; 34(10):3653-67. PMID: 24599464; PMCID: PMC3942581.
  26. Tsai MF, Jiang D, Zhao L, Clapham D, Miller C. Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1. J Gen Physiol. 2014 Jan; 143(1):67-73. PMID: 24344246; PMCID: PMC3874562.
  27. Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12; 504(7479):311-4. PMID: 24336288; PMCID: PMC4112737.
  28. DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12; 504(7479):315-8. PMID: 24336289; PMCID: PMC4073646.
  29. Carvacho I, Lee HC, Fissore RA, Clapham DE. TRPV3 channels mediate strontium-induced mouse-egg activation. Cell Rep. 2013 Dec 12; 5(5):1375-86. PMID: 24316078; PMCID: PMC3918412.
  30. Clapham DE. The mother of all endocytosis. Elife. 2013 Nov 26; 2:e01738. PMID: 24282238; PMCID: PMC3839537.
  31. Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK. EMRE is an essential component of the mitochondrial calcium uniporter complex. Science. 2013 Dec 13; 342(6164):1379-82. PMID: 24231807; PMCID: PMC4091629.
  32. Clapham DE. Sperm BerserKers. Elife. 2013 Oct 08; 2:e01469. PMID: 24137547; PMCID: PMC3791457.
  33. Zeng XH, Navarro B, Xia XM, Clapham DE, Lingle CJ. Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. J Gen Physiol. 2013 Sep; 142(3):305-13. PMID: 23980198; PMCID: PMC3753610.
  34. Sah R, Mesirca P, Van den Boogert M, Rosen J, Mably J, Mangoni ME, Clapham DE. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):E3037-46. PMID: 23878236; PMCID: PMC3740880.
  35. Mesirca P, Marger L, Toyoda F, Rizzetto R, Audoubert M, Dubel S, Torrente AG, Difrancesco ML, Muller JC, Leoni AL, Couette B, Nargeot J, Clapham DE, Wickman K, Mangoni ME. The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. J Gen Physiol. 2013 Aug; 142(2):113-26. PMID: 23858001; PMCID: PMC3727310.
  36. Chaudhuri D, Sancak Y, Mootha VK, Clapham DE. MCU encodes the pore conducting mitochondrial calcium currents. Elife. 2013 Jun 04; 2:e00704. PMID: 23755363; PMCID: PMC3673318.
  37. Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation. 2013 Jul 09; 128(2):101-14. PMID: 23734001; PMCID: PMC3800036.
  38. Jiang D, Zhao L, Clish CB, Clapham DE. Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2249-54. PMID: 23716663; PMCID: PMC3683736.
  39. Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6364-9. PMID: 23542377; PMCID: PMC3631666.
  40. Miki K, Clapham DE. Rheotaxis guides mammalian sperm. Curr Biol. 2013 Mar 18; 23(6):443-52. PMID: 23453951; PMCID: PMC3607503.
  41. Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell. 2013 Feb 14; 152(4):778-790. PMID: 23394946; PMCID: PMC3908667.
  42. Bagnéris C, Decaen PG, Hall BA, Naylor CE, Clapham DE, Kay CW, Wallace BA. Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nat Commun. 2013; 4:2465. PMID: 24051986; PMCID: PMC3791462.
  43. Lishko P, Clapham DE, Navarro B, Kirichok Y. Sperm patch-clamp. Methods Enzymol. 2013; 525:59-83. PMID: 23522465; PMCID: PMC3909741.
  44. Zhang X, Xia M, Li Y, Liu H, Jiang X, Ren W, Wu J, DeCaen P, Yu F, Huang S, He J, Clapham DE, Yan N, Gong H. Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh. Cell Res. 2013 Mar; 23(3):409-22. PMID: 23247626; PMCID: PMC3587708.
  45. Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 2012 Oct 12; 151(2):372-83. PMID: 23063126; PMCID: PMC3475186.
  46. Stotz SC, Clapham DE. Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. PLoS One. 2012; 7(10):e46865. PMID: 23056495; PMCID: PMC3464265.
  47. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28; 151(1):96-110. PMID: 23021218; PMCID: PMC3477522.
  48. Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell. 2012 Jun 12; 22(6):1149-62. PMID: 22698280; PMCID: PMC3397829.
  49. Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham DE, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 2012 May 20; 486(7401):130-4. PMID: 22678295; PMCID: PMC3979295.
  50. Kaczmarek JS, Riccio A, Clapham DE. Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7888-92. PMID: 22547824; PMCID: PMC3356680.
  51. Wu LJ, Wu G, Akhavan Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci. 2012 Mar 04; 15(4):565-73. PMID: 22388960; PMCID: PMC3314139.
  52. Doerner JF, Febvay S, Clapham DE. Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL. Nat Commun. 2012; 3:990. PMID: 22871809; PMCID: PMC3651673.
  53. Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):E225-33. PMID: 22203997; PMCID: PMC3277139.
  54. Clapham DE, Miller C. A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):19492-7. PMID: 22109551; PMCID: PMC3241781.
  55. Krapivinsky G, Krapivinsky L, Stotz SC, Manasian Y, Clapham DE. POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19234-9. PMID: 22084111; PMCID: PMC3228472.
  56. Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW. Melanopsin signalling in mammalian iris and retina. Nature. 2011 Nov 02; 479(7371):67-73. PMID: 22051675; PMCID: PMC3270891.
  57. Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):18114-9. PMID: 22025699; PMCID: PMC3207667.
  58. Lishko PV, Kirichok Y, Ren D, Navarro B, Chung JJ, Clapham DE. The control of male fertility by spermatozoan ion channels. Annu Rev Physiol. 2012; 74:453-75. PMID: 22017176; PMCID: PMC3914660.
  59. Navarro B, Miki K, Clapham DE. ATP-activated P2X2 current in mouse spermatozoa. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14342-7. PMID: 21831833; PMCID: PMC3161588.
  60. Cai X, Clapham DE. Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Mol Biol Evol. 2012 Jan; 29(1):91-100. PMID: 21680871; PMCID: PMC4037924.
  61. Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun. 2011 Jan 11; 2:153. PMID: 21224844.
    View in: PubMed
  62. Bates-Withers C, Sah R, Clapham DE. TRPM7, the Mg(2+) inhibited channel and kinase. Adv Exp Med Biol. 2011; 704:173-83. PMID: 21290295.
    View in: PubMed
  63. Wu LJ, Sweet TB, Clapham DE. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev. 2010 Sep; 62(3):381-404. PMID: 20716668; PMCID: PMC2964900.
  64. Ramsey IS, Mokrab Y, Carvacho I, Sands ZA, Sansom MSP, Clapham DE. An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1. Nat Struct Mol Biol. 2010 Jul; 17(7):869-875. PMID: 20543828; PMCID: PMC4035905.
  65. Febvay S, Marini DM, Belcher AM, Clapham DE. Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption. Nano Lett. 2010 Jun 09; 10(6):2211-9. PMID: 20446663; PMCID: PMC4058846.
  66. Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, Clapham DE, Xu H. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 2010 Apr 16; 141(2):331-43. PMID: 20403327; PMCID: PMC2858065.
  67. Jiang D, Zhao L, Clapham DE. Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science. 2009 Oct 02; 326(5949):144-7. PMID: 19797662; PMCID: PMC4067766.
  68. Zhou H, Clapham DE. Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15750-5. PMID: 19717468.
    View in: PubMed
  69. Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 2009 May 15; 137(4):761-72. PMID: 19450521; PMCID: PMC2719954.
  70. Oancea E, Vriens J, Brauchi S, Jun J, Splawski I, Clapham DE. TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal. 2009 May 12; 2(70):ra21. PMID: 19436059; PMCID: PMC4086358.
  71. Blair NT, Kaczmarek JS, Clapham DE. Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol. 2009 May; 133(5):525-46. PMID: 19398778; PMCID: PMC2712973.
  72. Ramsey IS, Ruchti E, Kaczmarek JS, Clapham DE. Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7642-7. PMID: 19372380.
    View in: PubMed
  73. Clapham DE. A STIMulus Package puts orai calcium channels to work. Cell. 2009 Mar 06; 136(5):814-6. PMID: 19269360.
    View in: PubMed
  74. Zimmermann K, Hein A, Hager U, Kaczmarek JS, Turnquist BP, Clapham DE, Reeh PW. Phenotyping sensory nerve endings in vitro in the mouse. Nat Protoc. 2009; 4(2):174-96. PMID: 19180088; PMCID: PMC4082318.
  75. Jin J, Desai BN, Navarro B, Donovan A, Andrews NC, Clapham DE. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science. 2008 Oct 31; 322(5902):756-60. PMID: 18974357; PMCID: PMC2605283.
  76. Cai X, Clapham DE. Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. PLoS One. 2008; 3(10):e3569. PMID: 18974790; PMCID: PMC2572835.
  77. Brauchi S, Krapivinsky G, Krapivinsky L, Clapham DE. TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8304-8. PMID: 18539771; PMCID: PMC2422775.
  78. Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE. Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008 May 07; 3(5):e2082. PMID: 18461159; PMCID: PMC2346451.
  79. Musset B, Cherny VV, Morgan D, Okamura Y, Ramsey IS, Clapham DE, DeCoursey TE. Detailed comparison of expressed and native voltage-gated proton channel currents. J Physiol. 2008 May 15; 586(10):2477-86. PMID: 18356202; PMCID: PMC2464343.
  80. Rama S, Krapivinsky G, Clapham DE, Medina I. The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP. Mol Cell Neurosci. 2008 Jun; 38(2):183-8. PMID: 18417361; PMCID: PMC4057800.
  81. Navarro B, Kirichok Y, Chung JJ, Clapham DE. Ion channels that control fertility in mammalian spermatozoa. Int J Dev Biol. 2008; 52(5-6):607-13. PMID: 18649274; PMCID: PMC4297656.
  82. Clapham DE. Calcium signaling. Cell. 2007 Dec 14; 131(6):1047-58. PMID: 18083096.
    View in: PubMed
  83. Fujinami S, Sato T, Trimmer JS, Spiller BW, Clapham DE, Krulwich TA, Kawagishi I, Ito M. The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4. Microbiology. 2007 Dec; 153(Pt 12):4027-38. PMID: 18048917; PMCID: PMC2556953.
  84. Xu H, Delling M, Li L, Dong X, Clapham DE. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18321-6. PMID: 17989217; PMCID: PMC2084341.
  85. Liu J, Xia J, Cho KH, Clapham DE, Ren D. CatSperbeta, a novel transmembrane protein in the CatSper channel complex. J Biol Chem. 2007 Jun 29; 282(26):18945-52. PMID: 17478420.
    View in: PubMed
  86. Navarro B, Kirichok Y, Clapham DE. KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7688-92. PMID: 17460039; PMCID: PMC1855916.
  87. Clapham DE. SnapShot: mammalian TRP channels. Cell. 2007 Apr 06; 129(1):220. PMID: 17418797.
    View in: PubMed
  88. Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1219-23. PMID: 17227845; PMCID: PMC1770895.
  89. Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell. 2006 Dec 15; 127(6):1137-50. PMID: 17123591.
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  90. Krapivinsky G, Mochida S, Krapivinsky L, Cibulsky SM, Clapham DE. The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron. 2006 Nov 09; 52(3):485-96. PMID: 17088214.
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  91. Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DE. Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem. 2006 Oct 06; 281(40):29897-904. PMID: 16899456.
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  92. Lambers TT, Mahieu F, Oancea E, Hoofd L, de Lange F, Mensenkamp AR, Voets T, Nilius B, Clapham DE, Hoenderop JG, Bindels RJ. Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. EMBO J. 2006 Jul 12; 25(13):2978-88. PMID: 16763551; PMCID: PMC1500989.
  93. Splawski I, Yoo DS, Stotz SC, Cherry A, Clapham DE, Keating MT. CACNA1H mutations in autism spectrum disorders. J Biol Chem. 2006 Aug 04; 281(31):22085-91. PMID: 16754686.
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  94. Xu H, Delling M, Jun JC, Clapham DE. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May; 9(5):628-35. PMID: 16617338.
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  95. Ramsey IS, Moran MM, Chong JA, Clapham DE. A voltage-gated proton-selective channel lacking the pore domain. Nature. 2006 Apr 27; 440(7088):1213-6. PMID: 16554753; PMCID: PMC4084761.
  96. Kirichok Y, Navarro B, Clapham DE. Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature. 2006 Feb 09; 439(7077):737-40. PMID: 16467839.
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  97. Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annu Rev Physiol. 2006; 68:619-47. PMID: 16460286.
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  98. Oancea E, Wolfe JT, Clapham DE. Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circ Res. 2006 Feb 03; 98(2):245-53. PMID: 16357306.
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  99. Clapham DE, Garbers DL. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. Pharmacol Rev. 2005 Dec; 57(4):451-4. PMID: 16382101.
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  100. Clapham DE, Julius D, Montell C, Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev. 2005 Dec; 57(4):427-50. PMID: 16382100.
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  101. Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev. 2005 Dec; 57(4):509-26. PMID: 16382105.
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  102. Xu H, Blair NT, Clapham DE. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci. 2005 Sep 28; 25(39):8924-37. PMID: 16192383.
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  103. Desai BN, Clapham DE. TRP channels and mice deficient in TRP channels. Pflugers Arch. 2005 Oct; 451(1):11-8. PMID: 16078044.
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  104. Reiser J, Polu KR, Möller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet. 2005 Jul; 37(7):739-44. PMID: 15924139; PMCID: PMC1360984.
  105. Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Mol Cell Biol. 2005 Apr; 25(7):2632-43. PMID: 15767669; PMCID: PMC1061635.
  106. Zhuang ZY, Xu H, Clapham DE, Ji RR. Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci. 2004 Sep 22; 24(38):8300-9. PMID: 15385613.
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  107. Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron. 2004 Aug 19; 43(4):563-74. PMID: 15312654.
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  108. Legin A, Rudnitskaya A, Clapham D, Seleznev B, Lord K, Vlasov Y. Electronic tongue for pharmaceutical analytics: quantification of tastes and masking effects. Anal Bioanal Chem. 2004 Sep; 380(1):36-45. PMID: 15365669.
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  109. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE. Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol. 2004 Aug; 6(8):709-20. PMID: 15258588.
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  110. Ito M, Xu H, Guffanti AA, Wei Y, Zvi L, Clapham DE, Krulwich TA. The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10566-71. PMID: 15243157; PMCID: PMC490023.
  111. Moran MM, Xu H, Clapham DE. TRP ion channels in the nervous system. Curr Opin Neurobiol. 2004 Jun; 14(3):362-9. PMID: 15194117.
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  112. Xu H, Jin J, DeFelice LJ, Andrews NC, Clapham DE. A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol. 2004 Mar; 2(3):E50. PMID: 15024413; PMCID: PMC368157.
  113. Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature. 2004 Jan 22; 427(6972):360-4. PMID: 14737170.
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  114. Khositseth, A, Clapham DE, and Ackerman, M. Intracellular signaling and regulation of cardiac ion channels. Cardiac Electrophysiology. 2004; 33-41.
  115. 80. Ackerman, M, and Clapham DE. Excitability and Conduction. The Molecular Basis of Heart Disease. 2004; 311-335.
  116. Clapham DE. Symmetry, selectivity, and the 2003 Nobel Prize. Cell. 2003 Dec 12; 115(6):641-6. PMID: 14675526.
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  117. Koishi R, Xu H, Ren D, Navarro B, Spiller BW, Shi Q, Clapham DE. A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem. 2004 Mar 05; 279(10):9532-8. PMID: 14665618.
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  118. Clapham DE. TRP channels as cellular sensors. Nature. 2003 Dec 04; 426(6966):517-24. PMID: 14654832.
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  119. Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev. 2003 Dec; 55(4):583-6. PMID: 14657415.
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  120. Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL, Babcock DF. CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):14864-8. PMID: 14657352; PMCID: PMC299831.
  121. Clapham DE, Montell C, Schultz G, Julius D. International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev. 2003 Dec; 55(4):591-6. PMID: 14657417.
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  122. Krapivinsky G, Krapivinsky L, Manasian Y, Ivanov A, Tyzio R, Pellegrino C, Ben-Ari Y, Clapham DE, Medina I. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron. 2003 Nov 13; 40(4):775-84. PMID: 14622581.
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  123. Greka A, Navarro B, Oancea E, Duggan A, Clapham DE. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci. 2003 Aug; 6(8):837-45. PMID: 12858178.
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  124. Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem. 2003 Oct 03; 278(40):39014-9. PMID: 12857742.
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  125. Oancea E, Bezzerides VJ, Greka A, Clapham DE. Mechanism of persistent protein kinase D1 translocation and activation. Dev Cell. 2003 Apr; 4(4):561-74. PMID: 12689594.
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  126. Wei X, Henke VG, Strübing C, Brown EB, Clapham DE. Real-time imaging of nuclear permeation by EGFP in single intact cells. Biophys J. 2003 Feb; 84(2 Pt 1):1317-27. PMID: 12547812; PMCID: PMC1302708.
  127. Catterall, WA, Chandy, KG, Clapham, DE, Gutman, GA, Hofmann, F, Harmar, AJ, Abernethy, DR, and M. Spedding. International Union of Pharmacology: Approaches to the nomenclature of voltage-gated ion channels. Pharmacological Reviews. 2003; 55:572-574.
  128. Sandler VM, Wang S, Angelo K, Lo HG, Breakefield XO, Clapham DE. Modified herpes simplex virus delivery of enhanced GFP into the central nervous system. J Neurosci Methods. 2002 Dec 15; 121(2):211-9. PMID: 12468010.
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  129. Yue L, Navarro B, Ren D, Ramos A, Clapham DE. The cation selectivity filter of the bacterial sodium channel, NaChBac. J Gen Physiol. 2002 Dec; 120(6):845-53. PMID: 12451053; PMCID: PMC2229573.
  130. Clapham DE. Sorting out MIC, TRP, and CRAC ion channels. J Gen Physiol. 2002 Aug; 120(2):217-20. PMID: 12149282; PMCID: PMC2234462.
  131. Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature. 2002 Jul 11; 418(6894):181-6. PMID: 12077604.
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  132. Runnels LW, Yue L, Clapham DE. The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol. 2002 May; 4(5):329-36. PMID: 11941371.
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  133. Clapham DE. Signal transduction. Hot and cold TRP ion channels. Science. 2002 Mar 22; 295(5563):2228-9. PMID: 11910099.
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  134. Wickman K, Pu WT, Clapham DE. Structural characterization of the mouse Girk genes. Gene. 2002 Feb 06; 284(1-2):241-50. PMID: 11891065.
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  135. Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX. A unified nomenclature for the superfamily of TRP cation channels. Mol Cell. 2002 Feb; 9(2):229-31. PMID: 11864597.
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  136. Roberson, C, and Clapham, DE. . G protein-coupled receptor signaling through ion channels. GPCRs in the CNS- The GPCR Superfamily. 2002; 108-123.
  137. Ren D, Navarro B, Xu H, Yue L, Shi Q, Clapham DE. A prokaryotic voltage-gated sodium channel. Science. 2001 Dec 14; 294(5550):2372-5. PMID: 11743207.
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  138. Quill TA, Ren D, Clapham DE, Garbers DL. A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12527-31. PMID: 11675491; PMCID: PMC60087.
  139. Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE. A sperm ion channel required for sperm motility and male fertility. Nature. 2001 Oct 11; 413(6856):603-9. PMID: 11595941.
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  140. Clapham D, Michel T, Seidman C. In memorium. J Mol Cell Cardiol. 2001 Aug; 33(8):1393-4. PMID: 11448127.
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  141. Kovoor P, Wickman K, Maguire CT, Pu W, Gehrmann J, Berul CI, Clapham DE. Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. J Am Coll Cardiol. 2001 Jun 15; 37(8):2136-43. PMID: 11419900.
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  142. Lindroth AM, Saarikoski P, Flygh G, Clapham D, Grönroos R, Thelander M, Ronne H, von Arnold S. Two S-adenosylmethionine synthetase-encoding genes differentially expressed during adventitious root development in Pinus contorta. Plant Mol Biol. 2001 Jun; 46(3):335-46. PMID: 11488480.
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  143. Clapham DE, Runnels LW, Strübing C. The TRP ion channel family. Nat Rev Neurosci. 2001 Jun; 2(6):387-96. PMID: 11389472.
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  144. O'Connell PJ, Klyachko VA, Badminton MN, Thomson AW, Jackson MB, Clapham DE, Ahern GP. Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway. J Immunol. 2001 May 15; 166(10):6126-33. PMID: 11342632.
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  145. Yue L, Peng JB, Hediger MA, Clapham DE. CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature. 2001 Apr 05; 410(6829):705-9. PMID: 11287959.
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  146. Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron. 2001 Mar; 29(3):645-55. PMID: 11301024.
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  147. Runnels LW, Yue L, Clapham DE. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science. 2001 Feb 09; 291(5506):1043-7. PMID: 11161216.
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  148. Corey S, Clapham DE. The Stoichiometry of Gbeta gamma binding to G-protein-regulated inwardly rectifying K+ channels (GIRKs). J Biol Chem. 2001 Apr 06; 276(14):11409-13. PMID: 11148218.
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  149. Clapham D. How to lose your hippocampus by working on chloride channels. Neuron. 2001 Jan; 29(1):1-3. PMID: 11182073.
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  150. Clapham DE. . Intracellular calcium signaling. Roger Eckert Memorial Lecture. 2001.
  151. Jelacic TM, Kennedy ME, Wickman K, Clapham DE. Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. J Biol Chem. 2000 Nov 17; 275(46):36211-6. PMID: 10956667.
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  152. Medina I, Krapivinsky G, Arnold S, Kovoor P, Krapivinsky L, Clapham DE. A switch mechanism for G beta gamma activation of I(KACh). J Biol Chem. 2000 Sep 22; 275(38):29709-16. PMID: 10900209.
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  153. Wickman K, Karschin C, Karschin A, Picciotto MR, Clapham DE. Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4. J Neurosci. 2000 Aug 01; 20(15):5608-15. PMID: 10908597.
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  154. Franco-Obregón A, Wang HW, Clapham DE. Distinct ion channel classes are expressed on the outer nuclear envelope of T- and B-lymphocyte cell lines. Biophys J. 2000 Jul; 79(1):202-14. PMID: 10866948; PMCID: PMC1300926.
  155. Pu WT, Wickman K, Clapham DE. ICln is essential for cellular and early embryonic viability. J Biol Chem. 2000 Apr 28; 275(17):12363-6. PMID: 10777517.
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  156. Sabala I, Elfstrand M, Farbos I, Clapham D, von Arnold S. Tissue-specific expression of Pa18, a putative lipid transfer protein gene, during embryo development in Norway spruce (Picea abies). Plant Mol Biol. 2000 Feb; 42(3):461-78. PMID: 10798616.
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  157. Clapham DE. Remembering Eva Neer. Cell. 2000.
  158. Clapham DE. More pieces of the K+ ion channel puzzle. Nat Struct Biol. 1999 Sep; 6(9):807-10. PMID: 10467088.
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  159. Wang H, Clapham DE. Conformational changes of the in situ nuclear pore complex. Biophys J. 1999 Jul; 77(1):241-7. PMID: 10388753; PMCID: PMC1300325.
  160. Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE. pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. Mol Cell Biol. 1999 Jun; 19(6):4113-20. PMID: 10330151; PMCID: PMC104370.
  161. Clapham DE. Unlocking family secrets: K+ channel transmembrane domains. Cell. 1999 May 28; 97(5):547-50. PMID: 10367883.
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  162. Jelacic TM, Sims SM, Clapham DE. Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3. J Membr Biol. 1999 May 15; 169(2):123-9. PMID: 10341034.
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  163. Arnold DB, Clapham DE. Molecular determinants for subcellular localization of PSD-95 with an interacting K+ channel. Neuron. 1999 May; 23(1):149-57. PMID: 10402201.
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  164. Wickman K, Krapivinsky G, Corey S, Kennedy M, Nemec J, Medina I, Clapham DE. Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh. Ann N Y Acad Sci. 1999 Apr 30; 868:386-98. PMID: 10414308.
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  165. Strübing C, Clapham DE. Active nuclear import and export is independent of lumenal Ca2+ stores in intact mammalian cells. J Gen Physiol. 1999 Feb; 113(2):239-48. PMID: 9925822; PMCID: PMC2223372.
  166. Kennedy ME, Nemec J, Corey S, Wickman K, Clapham DE. GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels. J Biol Chem. 1999 Jan 22; 274(4):2571-82. PMID: 9891030.
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  167. Nemec J, Wickman K, Clapham DE. Gbetagamma binding increases the open time of IKACh: kinetic evidence for multiple Gbetagamma binding sites. Biophys J. 1999 Jan; 76(1 Pt 1):246-52. PMID: 9876138; PMCID: PMC1302515.
  168. Ackerman, M, and Clapham DE. G proteins and ion channels. Cardiac Electrophysiology. 1999; 112-118.
  169. Navarro, B, Corey, S, Kennedy, M, and Clapham DE. G-protein-gated potassium channels: Implications for the weaver mouse. Potassium Ion Channels: Molecular Structure, Function, and Diseases. 1999; 46:295-320.
  170. Franco-Obregón A, Clapham DE. Touch channels sense blood pressure. Neuron. 1998 Dec; 21(6):1224-6. PMID: 9883713.
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  171. Corey S, Clapham DE. Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers. J Biol Chem. 1998 Oct 16; 273(42):27499-504. PMID: 9765280.
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  172. Krapivinsky G, Kennedy ME, Nemec J, Medina I, Krapivinsky L, Clapham DE. Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation. J Biol Chem. 1998 Jul 03; 273(27):16946-52. PMID: 9642257.
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  173. Clapham DE. Not so funny anymore: pacing channels are cloned. Neuron. 1998 Jul; 21(1):5-7. PMID: 9697846.
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  174. Schiller J, Schiller Y, Clapham DE. NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation. Nat Neurosci. 1998 Jun; 1(2):114-8. PMID: 10195125.
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  175. Clapham DE. The list of potential volume-sensitive chloride currents continues to swell (and shrink). J Gen Physiol. 1998 May; 111(5):623-4. PMID: 9565400; PMCID: PMC2217136.
  176. Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE. pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. J Biol Chem. 1998 May 01; 273(18):10811-4. PMID: 9556550.
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  177. Clapham DE. At last, the structure of an ion-selective channel. Nat Struct Biol. 1998 May; 5(5):342-4. PMID: 9586991.
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  178. Krapivinsky G, Medina I, Eng L, Krapivinsky L, Yang Y, Clapham DE. A novel inward rectifier K+ channel with unique pore properties. Neuron. 1998 May; 20(5):995-1005. PMID: 9620703.
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  179. Lorenz E, Alekseev AE, Krapivinsky GB, Carrasco AJ, Clapham DE, Terzic A. Evidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel. Mol Cell Biol. 1998 Mar; 18(3):1652-9. PMID: 9488482; PMCID: PMC108880.
  180. Corey S, Krapivinsky G, Krapivinsky L, Clapham DE. Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh. J Biol Chem. 1998 Feb 27; 273(9):5271-8. PMID: 9478984.
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  181. Lee MA, Dunn RC, Clapham DE, Stehno-Bittel L. Calcium regulation of nuclear pore permeability. Cell Calcium. 1998 Feb-Mar; 23(2-3):91-101. PMID: 9601604.
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  182. Wickman K, Nemec J, Gendler SJ, Clapham DE. Abnormal heart rate regulation in GIRK4 knockout mice. Neuron. 1998 Jan; 20(1):103-14. PMID: 9459446.
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  183. Clapham DE. Some like it hot: spicing up ion channels. Nature. 1997 Oct 23; 389(6653):783-4. PMID: 9349801.
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  184. Perez-Terzic C, Jaconi M, Clapham DE. Nuclear calcium and the regulation of the nuclear pore complex. Bioessays. 1997 Sep; 19(9):787-92. PMID: 9297969.
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  185. Jaconi M, Pyle J, Bortolon R, Ou J, Clapham D. Calcium release and influx colocalize to the endoplasmic reticulum. Curr Biol. 1997 Aug 01; 7(8):599-602. PMID: 9259550.
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  186. Ackerman MJ, Clapham DE. Ion channels--basic science and clinical disease. N Engl J Med. 1997 May 29; 336(22):1575-86. PMID: 9164815.
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  187. Perez-Terzic C, Stehno-Bittel L, Clapham DE. Nucleoplasmic and cytoplasmic differences in the fluorescence properties of the calcium indicator Fluo-3. Cell Calcium. 1997 Apr; 21(4):275-82. PMID: 9160163.
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  188. Wickman K, Seldin MF, James MR, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Icln gene. Genomics. 1997 Mar 15; 40(3):402-8. PMID: 9073507.
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  189. Wickman K, Seldin MF, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Girk4 gene. Genomics. 1997 Mar 15; 40(3):395-401. PMID: 9073506.
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  190. Clapham DE, Neer EJ. G protein beta gamma subunits. Annu Rev Pharmacol Toxicol. 1997; 37:167-203. PMID: 9131251.
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  191. Clapham DE. The molecular control of cardiac ion channels. Heart Vessels. 1997; Suppl 12:168-9. PMID: 9476572.
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  192. Perez-Terzic C, Pyle J, Jaconi M, Stehno-Bittel L, Clapham DE. Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores. Science. 1996 Sep 27; 273(5283):1875-7. PMID: 8791595.
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  193. Clapham DE. Intracellular signalling: more jobs for G beta gamma. Curr Biol. 1996 Jul 01; 6(7):814-6. PMID: 8835861.
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  194. Navarro B, Kennedy ME, Velimirovíc B, Bhat D, Peterson AS, Clapham DE. Nonselective and G betagamma-insensitive weaver K+ channels. Science. 1996 Jun 28; 272(5270):1950-3. PMID: 8658170.
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  195. Clapham DE. TRP is cracked but is CRAC TRP? Neuron. 1996 Jun; 16(6):1069-72. PMID: 8663982.
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  196. Saarikoski P, Clapham D, von Arnold S. A wound-inducible gene from Salix viminalis coding for a trypsin inhibitor. Plant Mol Biol. 1996 Jun; 31(3):465-78. PMID: 8790281.
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  197. Aleksandrov A, Velimirovic B, Clapham DE. Inward rectification of the IRK1 K+ channel reconstituted in lipid bilayers. Biophys J. 1996 Jun; 70(6):2680-7. PMID: 8744305; PMCID: PMC1225247.
  198. Hedin KE, Lim NF, Clapham DE. Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits GIRK1 expression of IKACh currents in oocytes. Neuron. 1996 Feb; 16(2):423-9. PMID: 8789957.
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  199. Clapham DE. The G-protein nanomachine. Nature. 1996 Jan 25; 379(6563):297-9. PMID: 8552180.
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  200. Velimirovic BM, Gordon EA, Lim NF, Navarro B, Clapham DE. The K+ channel inward rectifier subunits form a channel similar to neuronal G protein-gated K+ channel. FEBS Lett. 1996 Jan 22; 379(1):31-7. PMID: 8566224.
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  201. Stehno-Bittel L, Perez-Terzic C, Luckhoff A, Clapham DE. Nuclear ion channels and regulation of the nuclear pore. Soc Gen Physiol Ser. 1996; 51:195-207. PMID: 8809944.
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  202. Kennedy ME, Nemec J, Clapham DE. Localization and interaction of epitope-tagged GIRK1 and CIR inward rectifier K+ channel subunits. Neuropharmacology. 1996; 35(7):831-9. PMID: 8938714.
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  203. Stehno-Bittel L, Perez-Terzic C, Clapham DE. Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca2+ store. Science. 1995 Dec 15; 270(5243):1835-8. PMID: 8525380.
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  204. Perez-Terzic CM, Chini EN, Shen SS, Dousa TP, Clapham DE. Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs. Biochem J. 1995 Dec 15; 312 ( Pt 3):955-9. PMID: 8554544; PMCID: PMC1136206.
  205. Stehno-Bittel L, Krapivinsky G, Krapivinsky L, Perez-Terzic C, Clapham DE. The G protein beta gamma subunit transduces the muscarinic receptor signal for Ca2+ release in Xenopus oocytes. J Biol Chem. 1995 Dec 15; 270(50):30068-74. PMID: 8530411.
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  206. Krapivinsky G, Krapivinsky L, Wickman K, Clapham DE. G beta gamma binds directly to the G protein-gated K+ channel, IKACh. J Biol Chem. 1995 Dec 08; 270(49):29059-62. PMID: 7493925.
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  207. Krapivinsky G, Krapivinsky L, Velimirovic B, Wickman K, Navarro B, Clapham DE. The cardiac inward rectifier K+ channel subunit, CIR, does not comprise the ATP-sensitive K+ channel, IKATP. J Biol Chem. 1995 Dec 01; 270(48):28777-9. PMID: 7499400.
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  208. Wickman K, Clapham DE. Ion channel regulation by G proteins. Physiol Rev. 1995 Oct; 75(4):865-85. PMID: 7480165.
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  209. Clapham DE. Intracellular calcium. Replenishing the stores. Nature. 1995 Jun 22; 375(6533):634-5. PMID: 7791893.
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  210. Wickman KD, Clapham DE. G-protein regulation of ion channels. Curr Opin Neurobiol. 1995 Jun; 5(3):278-85. PMID: 7580149.
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  211. Krapivinsky G, Gordon EA, Wickman K, Velimirovic B, Krapivinsky L, Clapham DE. The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature. 1995 Mar 09; 374(6518):135-41. PMID: 7877685.
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  212. Hedin KE, Appleby MW, Clapham DE. Developmental regulation of TCR-CD3-dependent [Ca2+]i responses of individual normal and pp59fyn-deficient T lymphocytes. Immunology. 1995 Feb; 84(2):183-92. PMID: 7750993; PMCID: PMC1415114.
  213. Clapham DE. Calcium signaling. Cell. 1995 Jan 27; 80(2):259-68. PMID: 7834745.
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  214. Stehno-Bittel L, Lückhoff A, Clapham DE. Calcium release from the nucleus by InsP3 receptor channels. Neuron. 1995 Jan; 14(1):163-7. PMID: 7530018.
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  215. Clapham DE, Sneyd J. Intracellular calcium waves. Adv Second Messenger Phosphoprotein Res. 1995; 30:1-24. PMID: 7695987.
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  216. Clapham DE. Signal transduction. Why testicles are cool. Nature. 1994 Sep 08; 371(6493):109-10. PMID: 8072540.
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  217. Lückhoff A, Clapham DE. Calcium channels activated by depletion of internal calcium stores in A431 cells. Biophys J. 1994 Jul; 67(1):177-82. PMID: 7918985; PMCID: PMC1225347.
  218. Wickman KD, Iñiguez-Lluhl JA, Davenport PA, Taussig R, Krapivinsky GB, Linder ME, Gilman AG, Clapham DE. Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature. 1994 Mar 17; 368(6468):255-7. PMID: 8145826.
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  219. Krapivinsky GB, Ackerman MJ, Gordon EA, Krapivinsky LD, Clapham DE. Molecular characterization of a swelling-induced chloride conductance regulatory protein, pICln. Cell. 1994 Feb 11; 76(3):439-48. PMID: 8313467.
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  220. Ackerman MJ, Wickman KD, Clapham DE. Hypotonicity activates a native chloride current in Xenopus oocytes. J Gen Physiol. 1994 Feb; 103(2):153-79. PMID: 8189203; PMCID: PMC2216836.
  221. Girard S, Clapham DE. Simultaneous near ultraviolet and visible excitation confocal microscopy of calcium transients in Xenopus oocytes. Methods Cell Biol. 1994; 40:263-84. PMID: 8201979.
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  222. Clapham DE. Direct G protein activation of ion channels? Annu Rev Neurosci. 1994; 17:441-64. PMID: 8210183.
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  223. Stehno-Bittel L, Amundson J, Clapham D. G-protein-mediated pathways assayed by electrophysiology and confocal microscopy. Methods Enzymol. 1994; 238:321-35. PMID: 7799799.
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  224. Ackerman MJ, Krapivinsky GB, Gordon E, Krapivinsky L, Clapham DC. Characterization of a native swelling-induced chloride current, ICl.swell, and its regulatory protein, pICln, in Xenopus oocytes. Jpn J Physiol. 1994; 44 Suppl 2:S17-24. PMID: 7752522.
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  225. Clapham DE. Mutations in G protein-linked receptors: novel insights on disease. Cell. 1993 Dec 31; 75(7):1237-9. PMID: 8269505.
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  226. Chris Bliton, James Lechleiter, and David Clapham. Confocal imaging system for visible and ultraviolet light. 1993.
  227. Atri A, Amundson J, Clapham D, Sneyd J. A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte. Biophys J. 1993 Oct; 65(4):1727-39. PMID: 8274661; PMCID: PMC1225900.
  228. Clapham DE, Neer EJ. New roles for G-protein beta gamma-dimers in transmembrane signalling. Nature. 1993 Sep 30; 365(6445):403-6. PMID: 8413584.
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  229. Hedin KE, Duerson K, Clapham DE. Specificity of receptor-G protein interactions: searching for the structure behind the signal. Cell Signal. 1993 Sep; 5(5):505-18. PMID: 8312128.
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  230. Clapham DE. Cellular calcium. A mysterious new influx factor? Nature. 1993 Aug 26; 364(6440):763-4. PMID: 8395023.
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  231. Clapham DE. Reply. Trends Cardiovasc Med. 1993 Jul-Aug; 3(4):114. PMID: 21244935.
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  232. Duerson K, Carroll R, Clapham D. Alpha-helical distorting substitution disrupt coupling between m3 muscarinic receptor and G proteins. FEBS Lett. 1993 Jun 07; 324(1):103-8. PMID: 7684986.
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  233. Amundson J, Clapham D. Calcium waves. Curr Opin Neurobiol. 1993 Jun; 3(3):375-82. PMID: 8396478.
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  234. Girard S, Clapham D. Acceleration of intracellular calcium waves in Xenopus oocytes by calcium influx. Science. 1993 Apr 09; 260(5105):229-32. PMID: 8385801.
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  235. Sneyd J, Girard S, Clapham D. Calcium wave propagation by calcium-induced calcium release: an unusual excitable system. Bull Math Biol. 1993 Mar; 55(2):315-44. PMID: 8431705.
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  236. Ackerman MJ, Clapham DE. Cardiac chloride channels. Trends Cardiovasc Med. 1993 Jan-Feb; 3(1):23-8. PMID: 21244967.
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  237. Clapham DE, Lechleiter JD, Girard S. Intracellular waves observed by confocal microscopy from Xenopus oocytes. Adv Second Messenger Phosphoprotein Res. 1993; 28:161-5. PMID: 8398398.
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  238. Lechleiter JD, Clapham DE. Molecular mechanisms of intracellular calcium excitability in X. laevis oocytes. Cell. 1992 Apr 17; 69(2):283-94. PMID: 1568248.
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  239. Paulmichl M, Li Y, Wickman K, Ackerman M, Peralta E, Clapham D. New mammalian chloride channel identified by expression cloning. Nature. 1992 Mar 19; 356(6366):238-41. PMID: 1313151.
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  240. Girard S, Lückhoff A, Lechleiter J, Sneyd J, Clapham D. Two-dimensional model of calcium waves reproduces the patterns observed in Xenopus oocytes. Biophys J. 1992 Feb; 61(2):509-17. PMID: 1547335; PMCID: PMC1260265.
  241. Lückhoff A, Clapham DE. Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca(2+)-permeable channel. Nature. 1992 Jan 23; 355(6358):356-8. PMID: 1309941.
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  242. Lechleiter JD, Clapham DE. Spiral waves and intracellular calcium signalling. J Physiol Paris. 1992; 86(1-3):123-8. PMID: 1343590.
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  243. Neer EJ, Clapham DE. Signal transduction through G proteins in the cardiac myocyte. Trends Cardiovasc Med. 1992 Jan-Feb; 2(1):6-11. PMID: 21239281.
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  244. Wallert MA, Ackerman MJ, Kim D, Clapham DE. Two novel cardiac atrial K+ channels, IK.AA and IK.PC. J Gen Physiol. 1991 Nov; 98(5):921-39. PMID: 1765763; PMCID: PMC2229095.
  245. Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, Clapham DE. Cloning and expression of a rat cardiac delayed rectifier potassium channel. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7892-5. PMID: 1715584; PMCID: PMC52410.
  246. Tabares L, Mazzanti M, Clapham DE. Chloride channels in the nuclear membrane. J Membr Biol. 1991 Jul; 123(1):49-54. PMID: 1723103.
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  247. Lechleiter J, Girard S, Clapham D, Peralta E. Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors. Nature. 1991 Apr 11; 350(6318):505-8. PMID: 1849616.
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  248. Lechleiter J, Girard S, Peralta E, Clapham D. Spiral calcium wave propagation and annihilation in Xenopus laevis oocytes. Science. 1991 Apr 05; 252(5002):123-6. PMID: 2011747.
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  249. Lechleiter J, Hellmiss R, Duerson K, Ennulat D, David N, Clapham D, Peralta E. Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes. EMBO J. 1990 Dec; 9(13):4381-90. PMID: 2124972; PMCID: PMC552228.
  250. Lewis DL, Lechleiter JD, Kim D, Nanavati C, Clapham DE. Intracellular regulation of ion channels in cell membranes. Mayo Clin Proc. 1990 Aug; 65(8):1127-43. PMID: 1697015.
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  251. Clapham DE. Arachidonic acid and its metabolites in the regulation of G-protein gated K+ channels in atrial myocytes. Biochem Pharmacol. 1990 Mar 01; 39(5):813-5. PMID: 2106888.
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  252. Nanavati C, Clapham DE, Ito H, Kurachi Y. A comparison of the roles of purified G protein subunits in the activation of the cardiac muscarinic K+ channel. Soc Gen Physiol Ser. 1990; 45:29-41. PMID: 2116040.
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  253. Lechleiter J, Peralta E, Clapham D. Diverse functions of muscarinic acetylcholine receptor subtypes. Trends Pharmacol Sci. 1989 Dec; Suppl:34-8. PMID: 2694520.
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  254. Lewis DL, Clapham DE. Somatostatin activates an inwardly rectifying K+ channel in neonatal rat atrial cells. Pflugers Arch. 1989 Aug; 414(4):492-4. PMID: 2571974.
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  255. Kim D, Clapham DE. Potassium channels in cardiac cells activated by arachidonic acid and phospholipids. Science. 1989 Jun 09; 244(4909):1174-6. PMID: 2727703.
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  256. Kim D, Lewis DL, Graziadei L, Neer EJ, Bar-Sagi D, Clapham DE. G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. Nature. 1989 Feb 09; 337(6207):557-60. PMID: 2492640.
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  257. Clapham DE, Kim D. G protein activation mechanisms of the cardiac K+ channel, iK.ACh. Soc Gen Physiol Ser. 1989; 44:55-68. PMID: 2675324.
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  258. Logothetis DE, Kim DH, Northup JK, Neer EJ, Clapham DE. Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. Proc Natl Acad Sci U S A. 1988 Aug; 85(16):5814-8. PMID: 2457901; PMCID: PMC281855.
  259. Olesen SP, Davies PF, Clapham DE. Muscarinic-activated K+ current in bovine aortic endothelial cells. Circ Res. 1988 Jun; 62(6):1059-64. PMID: 2454760.
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  260. Clapham D, Neer E. Activation of atrial muscarinic-gated K+ channels by beta gamma-subunits of G proteins. Am J Physiol. 1988 Jun; 254(6 Pt 2):H1224. PMID: 2454588.
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  261. Davies PF, Olesen SP, Clapham DE, Morrel EM, Schoen FJ. Endothelial communication. State of the art lecture. Hypertension. 1988 Jun; 11(6 Pt 2):563-72. PMID: 2455686.
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  262. Neer EJ, Clapham DE. Roles of G protein subunits in transmembrane signalling. Nature. 1988 May 12; 333(6169):129-34. PMID: 3130578.
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  263. Fish RD, Sperti G, Colucci WS, Clapham DE. Phorbol ester increases the dihydropyridine-sensitive calcium conductance in a vascular smooth muscle cell line. Circ Res. 1988 May; 62(5):1049-54. PMID: 2452033.
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  264. Olesen SP, Clapham DE, Davies PF. Haemodynamic shear stress activates a K+ current in vascular endothelial cells. Nature. 1988 Jan 14; 331(6152):168-70. PMID: 2448637.
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  265. Clapham DE, Logothetis DE. Delayed rectifier K+ current in embryonic chick heart ventricle. Am J Physiol. 1988 Jan; 254(1 Pt 2):H192-7. PMID: 2827524.
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  266. Logothetis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE. The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature. 1987 Jan 22-28; 325(6102):321-6. PMID: 2433589.
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  267. Bormann J, Clapham DE. gamma-Aminobutyric acid receptor channels in adrenal chromaffin cells: a patch-clamp study. Proc Natl Acad Sci U S A. 1985 Apr; 82(7):2168-72. PMID: 2580307; PMCID: PMC397514.
  268. Clapham DE, Neher E. Trifluoperazine reduces inward ionic currents and secretion by separate mechanisms in bovine chromaffin cells. J Physiol. 1984 Aug; 353:541-64. PMID: 6090644; PMCID: PMC1193321.
  269. Ypey DL, Clapham DE. Development of a delayed outward-rectifying K+ conductance in cultured mouse peritoneal macrophages. Proc Natl Acad Sci U S A. 1984 May; 81(10):3083-7. PMID: 6328495; PMCID: PMC345225.
  270. Clapham DE, Neher E. Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells. J Physiol. 1984 Feb; 347:255-77. PMID: 6200595; PMCID: PMC1199446.
  271. Clapham DE, Defelice LJ. Voltage-activated k channels in embryonic chick heart. Biophys J. 1984 Jan; 45(1):40-2. PMID: 19431556.
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  272. Clapham DE, DeFelice LJ. Small signal impedance of heart cell membranes. J Membr Biol. 1982; 67(1):63-71. PMID: 7097756.
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  273. Clapham DE, Shrier A, DeHaan RL. Junctional resistance and action potential delay between embryonic heart cell aggregates. J Gen Physiol. 1980 Jun; 75(6):633-54. PMID: 7391810; PMCID: PMC2215265.
  274. Ypey DL, Clapham DE, DeHaan RL. Development of electrical coupling and action potential synchrony between paired aggregates of embryonic heart cells. J Membr Biol. 1979 Dec 12; 51(1):75-96. PMID: 522130.
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  275. Clapham DE, De Felice LJ. The theoretical small signal impedance of the frog node, Rana pipiens. Pflugers Arch. 1976 Nov 05; 366(2-3):273-6. PMID: 1087004.
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