Harvard Catalyst Profiles

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David Clapham, M.D., Ph.D.

Title
Institution
Department
Address
Phone
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Mentoring
completed student projects
External Calcium Modulates TRPC5 Activity
Summer, 06/20/05 - 08/15/05
A Study of Transient Receptor Channels (trp) in C Elegans
Summer, 05/20/99 - 09/01/99
Characterization of human STIM and Orai, putative regulators of cytosolic calcium signaling
Full Time, 09/15/06 - 03/30/07

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R56DK103739 (CLAPHAM, DAVID E.) Sep 1, 2015 - Aug 31, 2016
    NIH/NIDDK
    Direct measurement of polycystin channels and their regulation in cilia
    Role: Principal Investigator
  2. R01MH105851 (BOLSHAKOV, VADIM) Jul 1, 2015 - Mar 31, 2020
    NIH/NIMH
    TRPC-mediated control of anxiety
    Role: Co-Principal Investigator
  3. P01NS072040 (CLAPHAM, DAVID E.) Aug 1, 2011 - Jul 31, 2016
    NIH/NINDS
    TRP Channel Mediated Pain Circuitry
    Role: Co-Principal Investigator
  4. R01MH090293 (CLAPHAM, DAVID E.) Mar 15, 2010 - Dec 31, 2014
    NIH/NIMH
    Canonical Transient Receptor Potential (TRPC) subfamily function in Hippocampus.
    Role: Principal Investigator
  5. U01HD045857 (CLAPHAM, DAVID E.) Jan 30, 2004 - Jan 31, 2014
    NIH/NICHD
    CarSpers:sperm-specific ion channels;targets for male contraceptives
    Role: Principal Investigator
research resources
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Clapham Lab - Mouse strains (30)

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Duan J, Li Z, Li J, Hulse RE, Santa-Cruz A, Valinsky WC, Abiria SA, Krapivinsky G, Zhang J, Clapham DE. Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):E8201-E8210. PMID: 30108148.
    Citations: 1     Fields:    Translation:AnimalsCells
  2. Duan J, Li J, Zeng B, Chen GL, Peng X, Zhang Y, Wang J, Clapham DE, Li Z, Zhang J. Structure of the mouse TRPC4 ion channel. Nat Commun. 2018 08 06; 9(1):3102. PMID: 30082700.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  3. Hulse RE, Li Z, Huang RK, Zhang J, Clapham DE. Cryo-EM structure of the polycystin 2-l1 ion channel. Elife. 2018 07 13; 7. PMID: 30004384.
    Citations: 1     Fields:    
  4. Clapham DE. Influences: Short circuits. J Gen Physiol. 2018 04 02; 150(4):513-515. PMID: 29559507.
    Citations:    Fields:    
  5. Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J, Clapham DE. Structure of full-length human TRPM4. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):2377-2382. PMID: 29463718.
    Citations:    Fields:    Translation:Humans
  6. Liu X, Vien T, Duan J, Sheu SH, DeCaen PG, Clapham DE. Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium. Elife. 2018 02 14; 7. PMID: 29443690.
    Citations: 1     Fields:    
  7. Krapivinsky G, Krapivinsky L, Renthal NE, Santa-Cruz A, Manasian Y, Clapham DE. Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression. Proc Natl Acad Sci U S A. 2017 08 22; 114(34):E7092-E7100. PMID: 28784805.
    Citations:    Fields:    Translation:HumansCells
  8. Abiria SA, Krapivinsky G, Sah R, Santa-Cruz AG, Chaudhuri D, Zhang J, Adstamongkonkul P, DeCaen PG, Clapham DE. TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):E6079-E6088. PMID: 28696294.
    Citations: 4     Fields:    Translation:HumansCells
  9. Chung JJ, Miki K, Kim D, Shim SH, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, Clapham DE. CatSper? regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. Elife. 2017 02 23; 6. PMID: 28226241.
    Citations: 11     Fields:    Translation:AnimalsCells
  10. Platt CD, Chou J, Houlihan P, Badran YR, Kumar L, Bainter W, Poliani PL, Perez CJ, Dent SYR, Clapham DE, Benavides F, Geha RS. Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function. J Allergy Clin Immunol. 2017 Dec; 140(6):1651-1659.e1. PMID: 28192143.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  11. Pablo JL, DeCaen PG, Clapham DE. Progress in ciliary ion channel physiology. J Gen Physiol. 2017 Jan; 149(1):37-47. PMID: 27999145.
    Citations:    Fields:    Translation:HumansAnimalsCells
  12. Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E. The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell. 2016 Oct 20; 167(3):763-773.e11. PMID: 27768895.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  13. DeCaen PG, Liu X, Abiria S, Clapham DE. Atypical calcium regulation of the PKD2-L1 polycystin ion channel. Elife. 2016 06 27; 5. PMID: 27348301.
    Citations: 12     Fields:    Translation:HumansCells
  14. Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE. Primary cilia are not calcium-responsive mechanosensors. Nature. 2016 Mar 31; 531(7596):656-60. PMID: 27007841.
    Citations: 46     Fields:    Translation:AnimalsCells
  15. Chaudhuri D, Artiga DJ, Abiria SA, Clapham DE. Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):E1872-80. PMID: 26976564.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  16. Naylor CE, Bagnéris C, DeCaen PG, Sula A, Scaglione A, Clapham DE, Wallace BA. Molecular basis of ion permeability in a voltage-gated sodium channel. EMBO J. 2016 Apr 15; 35(8):820-30. PMID: 26873592.
    Citations: 18     Fields:    Translation:HumansCells
  17. Blair NT, Philipson BI, Richards PM, Doerner JF, Segura A, Silver WL, Clapham DE. Naturally Produced Defensive Alkenal Compounds Activate TRPA1. Chem Senses. 2016 05; 41(4):281-92. PMID: 26843529.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  18. Syeda SS, Carlson EJ, Miller MR, Francis R, Clapham DE, Lishko PV, Hawkinson JE, Hook D, Georg GI. The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex. ACS Chem Biol. 2016 Feb 19; 11(2):452-9. PMID: 26674547.
    Citations:    Fields:    Translation:HumansAnimalsCells
  19. Doerner JF, Delling M, Clapham DE. Ion channels and calcium signaling in motile cilia. Elife. 2015 Dec 09; 4. PMID: 26650848.
    Citations: 5     Fields:    
  20. Clapham DE. Structural biology: Pain-sensing TRPA1 channel resolved. Nature. 2015 Apr 23; 520(7548):439-41. PMID: 25855290.
    Citations:    Fields:    Translation:Humans
  21. Cai X, Wang X, Patel S, Clapham DE. Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view. Cell Calcium. 2015 Mar; 57(3):166-73. PMID: 25498309.
    Citations: 5     Fields:    Translation:AnimalsCells
  22. DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE. Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus. Elife. 2014 Nov 11; 3. PMID: 25385530.
    Citations: 8     Fields:    Translation:Cells
  23. Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D. Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. Neurosurgery. 2014 Aug; 61 Suppl 1:214. PMID: 25032616.
    Citations:    
  24. Cai X, Wang X, Clapham DE. Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex. Mol Biol Evol. 2014 Oct; 31(10):2735-40. PMID: 25063443.
    Citations: 10     Fields:    Translation:AnimalsCells
  25. Krapivinsky G, Krapivinsky L, Manasian Y, Clapham DE. The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase. Cell. 2014 May 22; 157(5):1061-72. PMID: 24855944.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  26. Bagnéris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA. Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8428-33. PMID: 24850863.
    Citations: 36     Fields:    Translation:HumansCells
  27. Chung JJ, Shim SH, Everley RA, Gygi SP, Zhuang X, Clapham DE. Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell. 2014 May 08; 157(4):808-22. PMID: 24813608.
    Citations: 29     Fields:    Translation:AnimalsCells
  28. Kahle KT, Khanna A, Clapham DE, Woolf CJ. Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain. JAMA Neurol. 2014 May; 71(5):640-5. PMID: 24615367.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  29. Chaudhuri D, Clapham DE. Outstanding questions regarding the permeation, selectivity, and regulation of the mitochondrial calcium uniporter. Biochem Biophys Res Commun. 2014 Jul 11; 449(4):367-9. PMID: 24792175.
    Citations: 3     Fields:    Translation:HumansCells
  30. Py BF, Jin M, Desai BN, Penumaka A, Zhu H, Kober M, Dietrich A, Lipinski MM, Henry T, Clapham DE, Yuan J. Caspase-11 controls interleukin-1ß release through degradation of TRPC1. Cell Rep. 2014 Mar 27; 6(6):1122-1128. PMID: 24630989.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  31. Riccio A, Li Y, Tsvetkov E, Gapon S, Yao GL, Smith KS, Engin E, Rudolph U, Bolshakov VY, Clapham DE. Decreased anxiety-like behavior and Gaq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. J Neurosci. 2014 Mar 05; 34(10):3653-67. PMID: 24599464.
    Citations: 20     Fields:    Translation:AnimalsCells
  32. Tsai MF, Jiang D, Zhao L, Clapham D, Miller C. Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1. J Gen Physiol. 2014 Jan; 143(1):67-73. PMID: 24344246.
    Citations: 26     Fields:    Translation:Humans
  33. Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12; 504(7479):311-4. PMID: 24336288.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  34. DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12; 504(7479):315-8. PMID: 24336289.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  35. Carvacho I, Lee HC, Fissore RA, Clapham DE. TRPV3 channels mediate strontium-induced mouse-egg activation. Cell Rep. 2013 Dec 12; 5(5):1375-86. PMID: 24316078.
    Citations: 12     Fields:    Translation:AnimalsCells
  36. Clapham DE. The mother of all endocytosis. Elife. 2013 Nov 26; 2:e01738. PMID: 24282238.
    Citations: 1     Fields:    Translation:AnimalsCells
  37. Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK. EMRE is an essential component of the mitochondrial calcium uniporter complex. Science. 2013 Dec 13; 342(6164):1379-82. PMID: 24231807.
    Citations: 125     Fields:    Translation:HumansCells
  38. Clapham DE. Sperm BerserKers. Elife. 2013 Oct 08; 2:e01469. PMID: 24137547.
    Citations: 3     Fields:    Translation:HumansCells
  39. Zeng XH, Navarro B, Xia XM, Clapham DE, Lingle CJ. Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. J Gen Physiol. 2013 Sep; 142(3):305-13. PMID: 23980198.
    Citations: 14     Fields:    Translation:AnimalsCells
  40. Sah R, Mesirca P, Van den Boogert M, Rosen J, Mably J, Mangoni ME, Clapham DE. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):E3037-46. PMID: 23878236.
    Citations: 23     Fields:    Translation:AnimalsCells
  41. Mesirca P, Marger L, Toyoda F, Rizzetto R, Audoubert M, Dubel S, Torrente AG, Difrancesco ML, Muller JC, Leoni AL, Couette B, Nargeot J, Clapham DE, Wickman K, Mangoni ME. The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. J Gen Physiol. 2013 Aug; 142(2):113-26. PMID: 23858001.
    Citations: 17     Fields:    Translation:AnimalsCells
  42. Chaudhuri D, Sancak Y, Mootha VK, Clapham DE. MCU encodes the pore conducting mitochondrial calcium currents. Elife. 2013 Jun 04; 2:e00704. PMID: 23755363.
    Citations: 47     Fields:    Translation:HumansCells
  43. Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation. 2013 Jul 09; 128(2):101-14. PMID: 23734001.
    Citations: 27     Fields:    Translation:AnimalsCells
  44. Jiang D, Zhao L, Clish CB, Clapham DE. Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2249-54. PMID: 23716663.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  45. Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6364-9. PMID: 23542377.
    Citations: 38     Fields:    Translation:HumansCells
  46. Miki K, Clapham DE. Rheotaxis guides mammalian sperm. Curr Biol. 2013 Mar 18; 23(6):443-52. PMID: 23453951.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  47. Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell. 2013 Feb 14; 152(4):778-790. PMID: 23394946.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  48. Bagnéris C, Decaen PG, Hall BA, Naylor CE, Clapham DE, Kay CW, Wallace BA. Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nat Commun. 2013; 4:2465. PMID: 24051986.
    Citations: 30     Fields:    Translation:Cells
  49. Lishko P, Clapham DE, Navarro B, Kirichok Y. Sperm patch-clamp. Methods Enzymol. 2013; 525:59-83. PMID: 23522465.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  50. Zhang X, Xia M, Li Y, Liu H, Jiang X, Ren W, Wu J, DeCaen P, Yu F, Huang S, He J, Clapham DE, Yan N, Gong H. Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh. Cell Res. 2013 Mar; 23(3):409-22. PMID: 23247626.
    Citations: 13     Fields:    Translation:AnimalsCells
  51. Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 2012 Oct 12; 151(2):372-83. PMID: 23063126.
    Citations: 134     Fields:    Translation:AnimalsCells
  52. Stotz SC, Clapham DE. Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. PLoS One. 2012; 7(10):e46865. PMID: 23056495.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  53. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28; 151(1):96-110. PMID: 23021218.
    Citations: 82     Fields:    Translation:AnimalsCells
  54. Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell. 2012 Jun 12; 22(6):1149-62. PMID: 22698280.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  55. Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham DE, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 2012 May 20; 486(7401):130-4. PMID: 22678295.
    Citations: 165     Fields:    Translation:HumansCells
  56. Kaczmarek JS, Riccio A, Clapham DE. Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7888-92. PMID: 22547824.
    Citations: 18     Fields:    Translation:AnimalsCells
  57. Wu LJ, Wu G, Akhavan Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci. 2012 Mar 04; 15(4):565-73. PMID: 22388960.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  58. Doerner JF, Febvay S, Clapham DE. Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL. Nat Commun. 2012; 3:990. PMID: 22871809.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  59. Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):E225-33. PMID: 22203997.
    Citations: 46     Fields:    Translation:AnimalsCells
  60. Clapham DE, Miller C. A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):19492-7. PMID: 22109551.
    Citations: 67     Fields:    Translation:HumansAnimals
  61. Krapivinsky G, Krapivinsky L, Stotz SC, Manasian Y, Clapham DE. POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19234-9. PMID: 22084111.
    Citations: 34     Fields:    Translation:HumansCells
  62. Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW. Melanopsin signalling in mammalian iris and retina. Nature. 2011 Nov 02; 479(7371):67-73. PMID: 22051675.
    Citations: 66     Fields:    Translation:AnimalsCells
  63. Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):18114-9. PMID: 22025699.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  64. Lishko PV, Kirichok Y, Ren D, Navarro B, Chung JJ, Clapham DE. The control of male fertility by spermatozoan ion channels. Annu Rev Physiol. 2012; 74:453-75. PMID: 22017176.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  65. Navarro B, Miki K, Clapham DE. ATP-activated P2X2 current in mouse spermatozoa. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14342-7. PMID: 21831833.
    Citations: 18     Fields:    Translation:AnimalsCells
  66. Cai X, Clapham DE. Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Mol Biol Evol. 2012 Jan; 29(1):91-100. PMID: 21680871.
    Citations: 23     Fields:    Translation:AnimalsCells
  67. Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun. 2011 Jan 11; 2:153. PMID: 21224844.
    Citations: 41     Fields:    
  68. Bates-Withers C, Sah R, Clapham DE. TRPM7, the Mg(2+) inhibited channel and kinase. Adv Exp Med Biol. 2011; 704:173-83. PMID: 21290295.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  69. Wu LJ, Sweet TB, Clapham DE. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev. 2010 Sep; 62(3):381-404. PMID: 20716668.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  70. Ramsey IS, Mokrab Y, Carvacho I, Sands ZA, Sansom MSP, Clapham DE. An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1. Nat Struct Mol Biol. 2010 Jul; 17(7):869-875. PMID: 20543828.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  71. Febvay S, Marini DM, Belcher AM, Clapham DE. Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption. Nano Lett. 2010 Jun 09; 10(6):2211-9. PMID: 20446663.
    Citations: 20     Fields:    Translation:HumansCells
  72. Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, Clapham DE, Xu H. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 2010 Apr 16; 141(2):331-43. PMID: 20403327.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  73. Jiang D, Zhao L, Clapham DE. Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science. 2009 Oct 02; 326(5949):144-7. PMID: 19797662.
    Citations: 157     Fields:    Translation:HumansAnimalsCells
  74. Zhou H, Clapham DE. Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15750-5. PMID: 19717468.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  75. Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 2009 May 15; 137(4):761-72. PMID: 19450521.
    Citations: 74     Fields:    Translation:AnimalsCells
  76. Oancea E, Vriens J, Brauchi S, Jun J, Splawski I, Clapham DE. TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal. 2009 May 12; 2(70):ra21. PMID: 19436059.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  77. Blair NT, Kaczmarek JS, Clapham DE. Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol. 2009 May; 133(5):525-46. PMID: 19398778.