Harvard Catalyst Profiles

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William Joseph Lane, M.D., Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Halls JBL, Vege S, Simmons DP, Aeschlimann J, Bujiriri B, Mah HH, Lebo MS, Vijay Kumar PK, Westhoff CM, Lane WJ. Overcoming the challenges of interpreting complex and uncommon RH alleles from whole genomes. Vox Sang. 2020 Jun 22. PMID: 32567058.
  2. Lane WJ, Gleadall NS, Aeschlimann J, Vege S, Sanchis-Juan A, Stephens J, Sullivan JC, Mah HH, Aguad M, Smeland-Wagman R, Lebo MS, Vijay Kumar PK, Kaufman RM, Green RC, Ouwehand WH, Westhoff CM. Multiple GYPB gene deletions associated with the U- phenotype in those of African ancestry. Transfusion. 2020 Jun; 60(6):1294-1307. PMID: 32473076.
  3. Sarkizova S, Klaeger S, Le PM, Li LW, Oliveira G, Keshishian H, Hartigan CR, Zhang W, Braun DA, Ligon KL, Bachireddy P, Zervantonakis IK, Rosenbluth JM, Ouspenskaia T, Law T, Justesen S, Stevens J, Lane WJ, Eisenhaure T, Lan Zhang G, Clauser KR, Hacohen N, Carr SA, Wu CJ, Keskin DB. A large peptidome dataset improves HLA class I epitope prediction across most of the human population. Nat Biotechnol. 2020 02; 38(2):199-209. PMID: 31844290.
  4. Lane WJ, Vege S, Mah HH, Lomas-Francis C, Aguad M, Smeland-Wagman R, Koch C, Killian JM, Gardner CL, De Castro M, Lebo MS, Kaufman RM, Green RC, Westhoff CM. Automated typing of red blood cell and platelet antigens from whole exome sequences. Transfusion. 2019 10; 59(10):3253-3263. PMID: 31392742.
  5. Gordon WJ, Ainsworth L, Aronson S, Baronas J, Kaufman RM, Guleria I, Milford EL, Oates M, Paz RD, Yeung MY, Lane WJ. Development of a Calculated Panel Reactive Antibody Web Service with Local Frequencies for Platelet Transfusion Refractoriness Risk Stratification. J Pathol Inform. 2019; 10:26. PMID: 31463162.
  6. Jan M, Leventhal MJ, Morgan EA, Wengrod JC, Nag A, Drinan SD, Wollison BM, Ducar MD, Thorner AR, Leppanen S, Baronas J, Stevens J, Lane WJ, Kekre N, Ho VT, Koreth J, Cutler CS, Nikiforow S, Alyea EP, Antin JH, Soiffer RJ, Ritz J, Lindsley RC, Ebert BL. Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation. Blood Adv. 2019 07 23; 3(14):2199-2204. PMID: 31324640.
  7. Lane WJ, Aguad M, Smeland-Wagman R, Vege S, Mah HH, Joseph A, Blout CL, Nguyen TT, Lebo MS, Sidhu M, Lomas-Francis C, Kaufman RM, Green RC, Westhoff CM. A whole genome approach for discovering the genetic basis of blood group antigens: independent confirmation for P1 and Xga. Transfusion. 2019 03; 59(3):908-915. PMID: 30592300.
    Citations:    Fields:    
  8. Keskin DB, Anandappa AJ, Sun J, Tirosh I, Mathewson ND, Li S, Oliveira G, Giobbie-Hurder A, Felt K, Gjini E, Shukla SA, Hu Z, Li L, Le PM, Allesøe RL, Richman AR, Kowalczyk MS, Abdelrahman S, Geduldig JE, Charbonneau S, Pelton K, Iorgulescu JB, Elagina L, Zhang W, Olive O, McCluskey C, Olsen LR, Stevens J, Lane WJ, Salazar AM, Daley H, Wen PY, Chiocca EA, Harden M, Lennon NJ, Gabriel S, Getz G, Lander ES, Regev A, Ritz J, Neuberg D, Rodig SJ, Ligon KL, Suvà ML, Wucherpfennig KW, Hacohen N, Fritsch EF, Livak KJ, Ott PA, Wu CJ, Reardon DA. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 2019 01; 565(7738):234-239. PMID: 30568305.
    Citations:    Fields:    
  9. Hu Z, Anandappa AJ, Sun J, Kim J, Leet DE, Bozym DJ, Chen C, Williams L, Shukla SA, Zhang W, Tabbaa D, Steelman S, Olive O, Livak KJ, Kishi H, Muraguchi A, Guleria I, Stevens J, Lane WJ, Burkhardt UE, Fritsch EF, Neuberg D, Ott PA, Keskin DB, Hacohen N, Wu CJ. A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens. Blood. 2018 11 01; 132(18):1911-1921. PMID: 30150207.
    Citations:    Fields:    
  10. Lane WJ, Westhoff CM, Gleadall NS, Aguad M, Smeland-Wagman R, Vege S, Simmons DP, Mah HH, Lebo MS, Walter K, Soranzo N, Di Angelantonio E, Danesh J, Roberts DJ, Watkins NA, Ouwehand WH, Butterworth AS, Kaufman RM, Rehm HL, Silberstein LE, Green RC. Automated typing of red blood cell and platelet antigens: a whole-genome sequencing study. Lancet Haematol. 2018 Jun; 5(6):e241-e251. PMID: 29780001.
    Citations:    Fields:    Translation:HumansCells
  11. Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, Eisenhaure T, Gjini E, Stevens J, Lane WJ, Javeri I, Nellaiappan K, Salazar AM, Daley H, Seaman M, Buchbinder EI, Yoon CH, Harden M, Lennon N, Gabriel S, Rodig SJ, Barouch DH, Aster JC, Getz G, Wucherpfennig K, Neuberg D, Ritz J, Lander ES, Fritsch EF, Hacohen N, Wu CJ. Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2018 03 14; 555(7696):402. PMID: 29542692.
    Citations: 1     Fields:    
  12. Flegel WA, Chen Q, Castilho L, Keller MA, Klapper EB, Lane WJ, Pirenne F, Stack G, St-Louis M, Tormey CA, Waxman DA, Weinstock C, Wendel S, Denomme GA. Molecular immunohaematology round table discussions at the AABB Annual Meeting, Orlando 2016. Blood Transfus. 2018 09; 16(5):447-456. PMID: 29517973.
    Citations:    Fields:    
  13. Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, Eisenhaure T, Gjini E, Stevens J, Lane WJ, Javeri I, Nellaiappan K, Salazar AM, Daley H, Seaman M, Buchbinder EI, Yoon CH, Harden M, Lennon N, Gabriel S, Rodig SJ, Barouch DH, Aster JC, Getz G, Wucherpfennig K, Neuberg D, Ritz J, Lander ES, Fritsch EF, Hacohen N, Wu CJ. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2017 07 13; 547(7662):217-221. PMID: 28678778.
    Citations: 115     Fields:    Translation:HumansCellsCTClinical Trials
  14. Gordon WJ, Baronas J, Lane WJ. A FHIR Human Leukocyte Antigen (HLA) Interface for Platelet Transfusion Support. Appl Clin Inform. 2017 06 07; 8(2):603-611. PMID: 28850154.
    Citations:    Fields:    Translation:Humans
  15. Wilen CB, Booth GS, Grossman BJ, Lane WJ, Szklarski PC, Jackups R. Using direct antiglobulin test results to reduce unnecessary cold agglutinin testing. Transfusion. 2017 06; 57(6):1480-1484. PMID: 28266038.
    Citations:    Fields:    Translation:Humans
  16. Flegel WA, Castilho L, Heaton WA, Keller MA, Klapper EB, Lane WJ, Pirenne F, Shehata N, Stack G, St-Louis M, Tormey CA, Wagner FF, Waxman DA, Denomme GA. Molecular immunohaematology round table discussions at the AABB Annual Meeting, Anaheim 2015. Blood Transfus. 2016 11; 14(6):557-565. PMID: 27483480.
    Citations:    Fields:    
  17. Lane WJ, Westhoff CM, Uy JM, Aguad M, Smeland-Wagman R, Kaufman RM, Rehm HL, Green RC, Silberstein LE. Comprehensive red blood cell and platelet antigen prediction from whole genome sequencing: proof of principle. Transfusion. 2016 Mar; 56(3):743-54. PMID: 26634332.
    Citations: 5     Fields:    Translation:HumansCells
  18. Shukla SA, Rooney MS, Rajasagi M, Tiao G, Dixon PM, Lawrence MS, Stevens J, Lane WJ, Dellagatta JL, Steelman S, Sougnez C, Cibulskis K, Kiezun A, Hacohen N, Brusic V, Wu CJ, Getz G. Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes. Nat Biotechnol. 2015 Nov; 33(11):1152-8. PMID: 26372948.
    Citations: 71     Fields:    Translation:Humans
  19. Garcia CA, Baron JM, Beckwith BA, Brodsky V, Dighe AS, Gudewicz TM, Kim JY, Klepeis VE, Lane WJ, Lee RE, Levy BP, Mahowald MA, Mandelker D, McClintock DS, Quinn AM, Rao LK, Riedlinger GM, Rudolf J, Gilbertson JR. Environmental components and methods for engaging pathology residents in informatics training. J Pathol Inform. 2015; 6:42. PMID: 26167386.
    Citations: 3     
  20. Vassy JL, McLaughlin HM, McLaughlin HL, MacRae CA, Seidman CE, Lautenbach D, Krier JB, Lane WJ, Kohane IS, Murray MF, McGuire AL, Rehm HL, Green RC. A one-page summary report of genome sequencing for the healthy adult. Public Health Genomics. 2015; 18(2):123-9. PMID: 25612602.
    Citations: 11     Fields:    Translation:Humans
  21. McLaughlin HM, Ceyhan-Birsoy O, Christensen KD, Kohane IS, Krier J, Lane WJ, Lautenbach D, Lebo MS, Machini K, MacRae CA, Azzariti DR, Murray MF, Seidman CE, Vassy JL, Green RC, Rehm HL. A systematic approach to the reporting of medically relevant findings from whole genome sequencing. BMC Med Genet. 2014 Dec 14; 15:134. PMID: 25714468.
    Citations: 24     Fields:    Translation:Humans
  22. Louis DN, Gerber GK, Baron JM, Bry L, Dighe AS, Getz G, Higgins JM, Kuo FC, Lane WJ, Michaelson JS, Le LP, Mermel CH, Gilbertson JR, Golden JA. Computational pathology: an emerging definition. Arch Pathol Lab Med. 2014 Sep; 138(9):1133-8. PMID: 25171694.
    Citations: 13     Fields:    Translation:Humans
  23. Mandelker D, Lee RE, Platt MY, Riedlinger G, Quinn A, Rao LK, Klepeis VE, Mahowald M, Lane WJ, Beckwith BA, Baron JM, McClintock DS, Kuo FC, Lebo MS, Gilbertson JR. Pathology informatics fellowship training: Focus on molecular pathology. J Pathol Inform. 2014; 5(1):11. PMID: 24843823.
    Citations: 3     
  24. Lee RE, McClintock DS, Balis UJ, Baron JM, Becich MJ, Beckwith BA, Brodsky VB, Carter AB, Dighe AS, Haghighi M, Hipp JD, Henricks WH, Kim JY, Klepseis VE, Kuo FC, Lane WJ, Levy BP, Onozato ML, Park SL, Sinard JH, Tuthill MJ, Gilbertson JR. Pathology informatics fellowship retreats: The use of interactive scenarios and case studies as pathology informatics teaching tools. J Pathol Inform. 2012; 3:41. PMID: 23248762.
    Citations: 6     
  25. Levy BP, McClintock DS, Lee RE, Lane WJ, Klepeis VE, Baron JM, Onozato ML, Kim J, Brodsky V, Beckwith B, Kuo F, Gilbertson JR. Different tracks for pathology informatics fellowship training: Experiences of and input from trainees in a large multisite fellowship program. J Pathol Inform. 2012; 3:30. PMID: 23024889.
    Citations: 9     
  26. McClintock DS, Levy BP, Lane WJ, Lee RE, Baron JM, Klepeis VE, Onozato ML, Kim J, Dighe AS, Beckwith BA, Kuo F, Black-Schaffer S, Gilbertson JR. A core curriculum for clinical fellowship training in pathology informatics. J Pathol Inform. 2012; 3:31. PMID: 23024890.
    Citations: 10     
  27. Paquette N, Conlon J, Sweet C, Rus F, Wilson L, Pereira A, Rosadini CV, Goutagny N, Weber AN, Lane WS, Shaffer SA, Maniatis S, Fitzgerald KA, Stuart L, Silverman N. Serine/threonine acetylation of TGFß-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12710-5. PMID: 22802624.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  28. Dilly GF, Young CR, Lane WS, Pangilinan J, Girguis PR. Exploring the limit of metazoan thermal tolerance via comparative proteomics: thermally induced changes in protein abundance by two hydrothermal vent polychaetes. Proc Biol Sci. 2012 Aug 22; 279(1741):3347-56. PMID: 22553092.
    Citations: 6     Fields:    Translation:Animals
  29. Prieto-García A, Zheng D, Adachi R, Xing W, Lane WS, Chung K, Anderson P, Hansbro PM, Castells M, Stevens RL. Mast cell restricted mouse and human tryptase·heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen. J Biol Chem. 2012 Mar 09; 287(11):7834-44. PMID: 22235124.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  30. Kobayashi T, Tsang WY, Li J, Lane W, Dynlacht BD. Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis. Cell. 2011 Jun 10; 145(6):914-25. PMID: 21620453.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  31. Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, Otto EA, Baye LM, Wen X, Scales SJ, Kwong M, Huntzicker EG, Sfakianos MK, Sandoval W, Bazan JF, Kulkarni P, Garcia-Gonzalo FR, Seol AD, O'Toole JF, Held S, Reutter HM, Lane WS, Rafiq MA, Noor A, Ansar M, Devi AR, Sheffield VC, Slusarski DC, Vincent JB, Doherty DA, Hildebrandt F, Reiter JF, Jackson PK. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell. 2011 May 13; 145(4):513-28. PMID: 21565611.
    Citations: 225     Fields:    Translation:HumansAnimalsCells
  32. Kim JS, Xu X, Li H, Solomon D, Lane WS, Jin T, Waldman T. Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol Cell Biol. 2011 Jul; 31(13):2756-71. PMID: 21536651.
    Citations: 17     Fields:    Translation:HumansCells
  33. Tinoco AD, Kim YG, Tagore DM, Wiwczar J, Lane WS, Danial NN, Saghatelian A. A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones. Biochemistry. 2011 Mar 29; 50(12):2213-22. PMID: 21299233.
    Citations: 6     Fields:    Translation:AnimalsCells
  34. Mukhopadhyay S, Wen X, Chih B, Nelson CD, Lane WS, Scales SJ, Jackson PK. TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev. 2010 Oct 01; 24(19):2180-93. PMID: 20889716.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  35. Opalka N, Brown J, Lane WJ, Twist KA, Landick R, Asturias FJ, Darst SA. Complete structural model of Escherichia coli RNA polymerase from a hybrid approach. PLoS Biol. 2010 Sep 14; 8(9). PMID: 20856905.
    Citations: 56     Fields:    Translation:Cells
  36. Yuan Z, Villagra A, Peng L, Coppola D, Glozak M, Sotomayor EM, Chen J, Lane WS, Seto E. The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions. Mol Cell Biol. 2010 Jun; 30(12):3004-15. PMID: 20368352.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  37. Nolte WM, Tagore DM, Lane WS, Saghatelian A. Peptidomics of prolyl endopeptidase in the central nervous system. Biochemistry. 2009 Dec 22; 48(50):11971-81. PMID: 19911840.
    Citations: 17     Fields:    Translation:AnimalsCells
  38. Cheng Q, Chen L, Li Z, Lane WS, Chen J. ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. EMBO J. 2009 Dec 16; 28(24):3857-67. PMID: 19816404.
    Citations: 61     Fields:    Translation:HumansCells
  39. Lane WJ, Darst SA. Molecular evolution of multisubunit RNA polymerases: sequence analysis. J Mol Biol. 2010 Jan 29; 395(4):671-85. PMID: 19895820.
    Citations: 61     Fields:    Translation:Cells
  40. Lane WJ, Darst SA. Molecular evolution of multisubunit RNA polymerases: structural analysis. J Mol Biol. 2010 Jan 29; 395(4):686-704. PMID: 19895816.
    Citations: 40     Fields:    Translation:Cells
  41. Peck GR, Chavez JA, Roach WG, Budnik BA, Lane WS, Karlsson HK, Zierath JR, Lienhard GE. Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation. J Biol Chem. 2009 Oct 30; 284(44):30016-23. PMID: 19740738.
    Citations: 29     Fields:    Translation:AnimalsCells
  42. Ertürk-Hasdemir D, Broemer M, Leulier F, Lane WS, Paquette N, Hwang D, Kim CH, Stöven S, Meier P, Silverman N. Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9779-84. PMID: 19497884.
    Citations: 45     Fields:    Translation:AnimalsCells
  43. Schweitzer MH, Zheng W, Organ CL, Avci R, Suo Z, Freimark LM, Lebleu VS, Duncan MB, Vander Heiden MG, Neveu JM, Lane WS, Cottrell JS, Horner JR, Cantley LC, Kalluri R, Asara JM. Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science. 2009 May 01; 324(5927):626-31. PMID: 19407199.
    Citations: 38     Fields:    Translation:AnimalsCells
  44. Whyte J, Bader JR, Tauhata SB, Raycroft M, Hornick J, Pfister KK, Lane WS, Chan GK, Hinchcliffe EH, Vaughan PS, Vaughan KT. Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis. J Cell Biol. 2008 Dec 01; 183(5):819-34. PMID: 19029334.
    Citations: 58     Fields:    Translation:HumansCells
  45. Tagore DM, Nolte WM, Neveu JM, Rangel R, Guzman-Rojas L, Pasqualini R, Arap W, Lane WS, Saghatelian A. Peptidase substrates via global peptide profiling. Nat Chem Biol. 2009 Jan; 5(1):23-5. PMID: 19011639.
    Citations: 26     Fields:    Translation:AnimalsCells
  46. Falick AM, Kowalak JA, Lane WS, Phinney BS, Turck CW, Weintraub ST, West KA, Neubert TA. ABRF-PRG05: de novo peptide sequence determination. J Biomol Tech. 2008 Sep; 19(4):251-7. PMID: 19137115.
    Citations: 1     Fields:    
  47. Kaushansky A, Gordus A, Budnik BA, Lane WS, Rush J, MacBeath G. System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol. 2008 Aug 25; 15(8):808-17. PMID: 18721752.
    Citations: 29     Fields:    Translation:HumansCells
  48. Gangopadhyay SS, Gallant C, Sundberg EJ, Lane WS, Morgan KG. Regulation of Ca2+/calmodulin kinase II by a small C-terminal domain phosphatase. Biochem J. 2008 Jun 15; 412(3):507-16. PMID: 18338982.
    Citations: 6     Fields:    Translation:AnimalsCells
  49. Shaw BF, Schneider GF, Bilgiçer B, Kaufman GK, Neveu JM, Lane WS, Whitelegge JP, Whitesides GM. Lysine acetylation can generate highly charged enzymes with increased resistance toward irreversible inactivation. Protein Sci. 2008 Aug; 17(8):1446-55. PMID: 18451358.
    Citations: 13     Fields:    Translation:Cells
  50. Buerki C, Rothgiesser KM, Valovka T, Owen HR, Rehrauer H, Fey M, Lane WS, Hottiger MO. Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Res. 2008 Mar; 36(5):1665-80. PMID: 18263619.
    Citations: 40     Fields:    Translation:AnimalsCells
  51. Chavez JA, Roach WG, Keller SR, Lane WS, Lienhard GE. Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem. 2008 Apr 04; 283(14):9187-95. PMID: 18258599.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  52. Rust MJ, Markson JS, Lane WS, Fisher DS, O'Shea EK. Ordered phosphorylation governs oscillation of a three-protein circadian clock. Science. 2007 Nov 02; 318(5851):809-12. PMID: 17916691.
    Citations: 114     Fields:    Translation:Cells
  53. Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, Koomen J, Olashaw N, Parsons JT, Yang XJ, Dent SR, Yao TP, Lane WS, Seto E. HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell. 2007 Jul 20; 27(2):197-213. PMID: 17643370.
    Citations: 189     Fields:    Translation:HumansAnimalsCells
  54. Yuan Z, Zhang X, Sengupta N, Lane WS, Seto E. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell. 2007 Jul 06; 27(1):149-62. PMID: 17612497.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  55. Patikoglou GA, Westblade LF, Campbell EA, Lamour V, Lane WJ, Darst SA. Crystal structure of the Escherichia coli regulator of sigma70, Rsd, in complex with sigma70 domain 4. J Mol Biol. 2007 Sep 21; 372(3):649-59. PMID: 17681541.
    Citations: 25     Fields:    Translation:Cells
  56. De Biasio A, Vrana JA, Zhou P, Qian L, Bieszczad CK, Braley KE, Domina AM, Weintraub SJ, Neveu JM, Lane WS, Craig RW. N-terminal truncation of antiapoptotic MCL1, but not G2/M-induced phosphorylation, is associated with stabilization and abundant expression in tumor cells. J Biol Chem. 2007 Aug 17; 282(33):23919-36. PMID: 17561513.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  57. Turck CW, Falick AM, Kowalak JA, Lane WS, Lilley KS, Phinney BS, Weintraub ST, Witkowska HE, Yates NA. The Association of Biomolecular Resource Facilities Proteomics Research Group 2006 study: relative protein quantitation. Mol Cell Proteomics. 2007 Aug; 6(8):1291-8. PMID: 17513294.
    Citations: 32     Fields:    
  58. Wegrzyn J, Lee J, Neveu JM, Lane WS, Hook V. Proteomics of neuroendocrine secretory vesicles reveal distinct functional systems for biosynthesis and exocytosis of peptide hormones and neurotransmitters. J Proteome Res. 2007 May; 6(5):1652-65. PMID: 17408250.
    Citations: 19     Fields:    Translation:AnimalsCells
  59. Arnott D, Gawinowicz MA, Kowalak JA, Lane WS, Speicher KD, Turck CW, West KA, Neubert TA. ABRF-PRG04: differentiation of protein isoforms. J Biomol Tech. 2007 Apr; 18(2):124-34. PMID: 17496225.
    Citations: 5     Fields:    Translation:Cells
  60. Liu QP, Sulzenbacher G, Yuan H, Bennett EP, Pietz G, Saunders K, Spence J, Nudelman E, Levery SB, White T, Neveu JM, Lane WS, Bourne Y, Olsson ML, Henrissat B, Clausen H. Bacterial glycosidases for the production of universal red blood cells. Nat Biotechnol. 2007 Apr; 25(4):454-64. PMID: 17401360.
    Citations: 38     Fields:    Translation:HumansCells
  61. Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell. 2006 Dec 28; 24(6):841-51. PMID: 17189187.
    Citations: 251     Fields:    Translation:HumansCells
  62. Damianov A, Kann M, Lane WS, Bindereif A. Human RBM28 protein is a specific nucleolar component of the spliceosomal snRNPs. Biol Chem. 2006 Oct-Nov; 387(10-11):1455-60. PMID: 17081119.
    Citations: 9     Fields:    Translation:HumansCells
  63. Wang P, Palfi Z, Preusser C, Lücke S, Lane WS, Kambach C, Bindereif A. Sm core variation in spliceosomal small nuclear ribonucleoproteins from Trypanosoma brucei. EMBO J. 2006 Oct 04; 25(19):4513-23. PMID: 16977313.
    Citations: 14     Fields:    Translation:AnimalsCells
  64. Lane WJ, Darst SA. The structural basis for promoter -35 element recognition by the group IV sigma factors. PLoS Biol. 2006 Sep; 4(9):e269. PMID: 16903784.
    Citations: 51     Fields:    Translation:Cells
  65. Kahsai AW, Zhu S, Wardrop DJ, Lane WS, Fenteany G. Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44. Chem Biol. 2006 Sep; 13(9):973-83. PMID: 16984887.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  66. Stein KK, Go JC, Lane WS, Primakoff P, Myles DG. Proteomic analysis of sperm regions that mediate sperm-egg interactions. Proteomics. 2006 Jun; 6(12):3533-43. PMID: 16758446.
    Citations: 24     Fields:    Translation:AnimalsCells
  67. Gridley S, Chavez JA, Lane WS, Lienhard GE. Adipocytes contain a novel complex similar to the tuberous sclerosis complex. Cell Signal. 2006 Oct; 18(10):1626-32. PMID: 16490346.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  68. Stockinger W, Zhang SC, Trivedi V, Jarzylo LA, Shieh EC, Lane WS, Castoreno AB, Nohturfft A. Differential requirements for actin polymerization, calmodulin, and Ca2+ define distinct stages of lysosome/phagosome targeting. Mol Biol Cell. 2006 Apr; 17(4):1697-710. PMID: 16452628.
    Citations: 11     Fields:    Translation:AnimalsCells
  69. Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W, Lane WS, Tan S, Yang XJ, Côté J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 06; 21(1):51-64. PMID: 16387653.
    Citations: 216     Fields:    Translation:HumansCells
  70. Ottosen S, Herrera FJ, Doroghazi JR, Hull A, Mittal S, Lane WS, Triezenberg SJ. Phosphorylation of the VP16 transcriptional activator protein during herpes simplex virus infection and mutational analysis of putative phosphorylation sites. Virology. 2006 Feb 20; 345(2):468-81. PMID: 16297954.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  71. Smith ER, Cayrou C, Huang R, Lane WS, Côté J, Lucchesi JC. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol Cell Biol. 2005 Nov; 25(21):9175-88. PMID: 16227571.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  72. He C, Hus JC, Sun LJ, Zhou P, Norman DP, Dötsch V, Wei H, Gross JD, Lane WS, Wagner G, Verdine GL. A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. Mol Cell. 2005 Oct 07; 20(1):117-29. PMID: 16209950.
    Citations: 21     Fields:    Translation:Cells
  73. Pasche B, Knobloch TJ, Bian Y, Liu J, Phukan S, Rosman D, Kaklamani V, Baddi L, Siddiqui FS, Frankel W, Prior TW, Schuller DE, Agrawal A, Lang J, Dolan ME, Vokes EE, Lane WS, Huang CC, Caldes T, Di Cristofano A, Hampel H, Nilsson I, von Heijne G, Fodde R, Murty VV, de la Chapelle A, Weghorst CM. Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA. 2005 Oct 05; 294(13):1634-46. PMID: 16204663.
    Citations: 40     Fields:    Translation:HumansCells
  74. Hassa PO, Haenni SS, Buerki C, Meier NI, Lane WS, Owen H, Gersbach M, Imhof R, Hottiger MO. Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem. 2005 Dec 09; 280(49):40450-64. PMID: 16204234.
    Citations: 98     Fields:    Translation:AnimalsCells
  75. Chen L, Gilkes DM, Pan Y, Lane WS, Chen J. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J. 2005 Oct 05; 24(19):3411-22. PMID: 16163388.
    Citations: 107     Fields:    Translation:HumansCells
  76. Hook V, Toneff T, Bogyo M, Greenbaum D, Medzihradszky KF, Neveu J, Lane W, Hook G, Reisine T. Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease. Biol Chem. 2005 Sep; 386(9):931-40. PMID: 16164418.
    Citations: 40     Fields:    Translation:AnimalsCells
  77. Zhu S, Mc Henry KT, Lane WS, Fenteany G. A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration. Chem Biol. 2005 Sep; 12(9):981-91. PMID: 16183022.
    Citations: 24     Fields:    Translation:AnimalsCells
  78. Johnson JL, Pacquelet S, Lane WS, Eam B, Catz SD. Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation. Traffic. 2005 Aug; 6(8):667-81. PMID: 15998322.
    Citations: 11     Fields:    Translation:HumansCells
  79. Lewis BA, Sims RJ, Lane WS, Reinberg D. Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. Mol Cell. 2005 May 13; 18(4):471-81. PMID: 15893730.
    Citations: 38     Fields:    Translation:HumansCells
  80. Clark DE, Williams CC, Duplessis TT, Moring KL, Notwick AR, Long W, Lane WS, Beuvink I, Hynes NE, Jones FE. ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events. J Biol Chem. 2005 Jun 24; 280(25):24175-80. PMID: 15863494.
    Citations: 17     Fields:    Translation:AnimalsCells
  81. Guettouche T, Boellmann F, Lane WS, Voellmy R. Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem. 2005 Mar 11; 6:4. PMID: 15760475.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  82. Shmelkov SV, Meeus S, Moussazadeh N, Kermani P, Rashbaum WK, Rabbany SY, Hanson MA, Lane WJ, St Clair R, Walsh KA, Dias S, Jacobson JT, Hempstead BL, Edelberg JM, Rafii S. Cytokine preconditioning promotes codifferentiation of human fetal liver CD133+ stem cells into angiomyogenic tissue. Circulation. 2005 Mar 08; 111(9):1175-83. PMID: 15753226.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  83. Gridley S, Lane WS, Garner CW, Lienhard GE. Novel insulin-elicited phosphoproteins in adipocytes. Cell Signal. 2005 Jan; 17(1):59-66. PMID: 15451025.
    Citations: 9     Fields:    Translation:AnimalsCells
  84. Davido DJ, von Zagorski WF, Lane WS, Schaffer PA. Phosphorylation site mutations affect herpes simplex virus type 1 ICP0 function. J Virol. 2005 Jan; 79(2):1232-43. PMID: 15613350.
    Citations: 23     Fields:    Translation:AnimalsCells
  85. Wang YG, Nnakwe C, Lane WS, Modesti M, Frank KM. Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase. J Biol Chem. 2004 Sep 03; 279(36):37282-90. PMID: 15194694.
    Citations: 28     Fields:    Translation:HumansCells
  86. Meek SE, Lane WS, Piwnica-Worms H. Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. J Biol Chem. 2004 Jul 30; 279(31):32046-54. PMID: 15161933.
    Citations: 80     Fields:    Translation:HumansCells
  87. Doyon Y, Selleck W, Lane WS, Tan S, Côté J. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol. 2004 Mar; 24(5):1884-96. PMID: 14966270.
    Citations: 198     Fields:    Translation:HumansAnimalsCells
  88. Kolesnikova TV, Stipp CS, Rao RM, Lane WS, Luscinskas FW, Hemler ME. EWI-2 modulates lymphocyte integrin alpha4beta1 functions. Blood. 2004 Apr 15; 103(8):3013-9. PMID: 15070678.
    Citations: 20     Fields:    Translation:HumansCells
  89. Loyola A, Huang JY, LeRoy G, Hu S, Wang YH, Donnelly RJ, Lane WS, Lee SC, Reinberg D. Functional analysis of the subunits of the chromatin assembly factor RSF. Mol Cell Biol. 2003 Oct; 23(19):6759-68. PMID: 12972596.
    Citations: 41     Fields:    Translation:HumansCells
  90. Polgár J, Lane WS, Chung SH, Houng AK, Reed GL. Phosphorylation of SNAP-23 in activated human platelets. J Biol Chem. 2003 Nov 07; 278(45):44369-76. PMID: 12930825.
    Citations: 31     Fields:    Translation:HumansCells
  91. Ohi R, Coughlin ML, Lane WS, Mitchison TJ. An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev Cell. 2003 Aug; 5(2):309-21. PMID: 12919681.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  92. Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Toneff T, Bundey R, Miller R, Schilling B, Petermann I, Dehnert J, Logvinova A, Goldsmith P, Neveu JM, Lane WS, Gibson B, Reinheckel T, Peters C, Bogyo M, Hook V. Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9590-5. PMID: 12869695.
    Citations: 64     Fields:    Translation:AnimalsCells
  93. Lee JC, Taylor CV, Gaucher SP, Toneff T, Taupenot L, Yasothornsrikul S, Mahata SK, Sei C, Parmer RJ, Neveu JM, Lane WS, Gibson BW, O'Connor DT, Hook VY. Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells. Biochemistry. 2003 Jun 17; 42(23):6938-46. PMID: 12795588.
    Citations: 11     Fields:    Translation:AnimalsCells
  94. Zhang XA, Lane WS, Charrin S, Rubinstein E, Liu L. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. Cancer Res. 2003 May 15; 63(10):2665-74. PMID: 12750295.
    Citations: 28     Fields:    Translation:HumansCells
  95. Friedl EM, Lane WS, Erdjument-Bromage H, Tempst P, Reinberg D. The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2328-33. PMID: 12591939.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  96. Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. J Biol Chem. 2003 Apr 25; 278(17):15123-7. PMID: 12584197.
    Citations: 19     Fields:    Translation:AnimalsCells
  97. Hui J, Stangl K, Lane WS, Bindereif A. HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol. 2003 Jan; 10(1):33-7. PMID: 12447348.
    Citations: 71     Fields:    Translation:HumansCells
  98. Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem. 2003 Feb 28; 278(9):7234-9. PMID: 12493763.
    Citations: 62     Fields:    Translation:HumansCells
  99. Wang Y, Cui H, Schroering A, Ding JL, Lane WS, McGill G, Fisher DE, Ding HF. NF-kappa B2 p100 is a pro-apoptotic protein with anti-oncogenic function. Nat Cell Biol. 2002 Nov; 4(11):888-93. PMID: 12389034.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  100. Miller SJ, Lou DY, Seldin DC, Lane WS, Neel BG. Direct identification of PTEN phosphorylation sites. FEBS Lett. 2002 Sep 25; 528(1-3):145-53. PMID: 12297295.
    Citations: 57     Fields:    Translation:HumansCells
  101. Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10353-8. PMID: 12149480.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  102. Nekhai S, Zhou M, Fernandez A, Lane WS, Lamb NJ, Brady J, Kumar A. HIV-1 Tat-associated RNA polymerase C-terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat-mediated transcription. Biochem J. 2002 Jun 15; 364(Pt 3):649-57. PMID: 12049628.
    Citations: 24     Fields:    Translation:HumansCells
  103. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7420-5. PMID: 12032298.
    Citations: 104     Fields:    Translation:HumansCells
  104. Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim ST, Lane WS, Kastan MB, D'Andrea AD. Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell. 2002 May 17; 109(4):459-72. PMID: 12086603.
    Citations: 132     Fields:    Translation:HumansCells
  105. Kane S, Sano H, Liu SC, Asara JM, Lane WS, Garner CC, Lienhard GE. A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J Biol Chem. 2002 Jun 21; 277(25):22115-8. PMID: 11994271.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  106. Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE. Insulin receptor substrate 4 associates with the protein IRAS. J Biol Chem. 2002 May 31; 277(22):19439-47. PMID: 11912194.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  107. Kim JH, Lane WS, Reinberg D. Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1241-6. PMID: 11818576.
    Citations: 53     Fields:    Translation:HumansCells
  108. Lane WJ, Hattori K, Dias S, Peerschke EI, Moore MA, Blanset DL, Lang PC, Petrone M, Rafii S. Anagrelide metabolite induces thrombocytopenia in mice by inhibiting megakaryocyte maturation without inducing platelet aggregation. Exp Hematol. 2001 Dec; 29(12):1417-24. PMID: 11750100.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  109. Lane WJ, Dias S, Hattori K, Heissig B, Choy M, Rabbany SY, Wood J, Moore MA, Rafii S. Stromal-derived factor 1-induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases. Blood. 2000 Dec 15; 96(13):4152-9. PMID: 11110686.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  110. Rabbany SY, Lane WJ, Marganski WA, Kusterbeck AW, Ligler FS. Trace detection of explosives using a membrane-based displacement immunoassay. J Immunol Methods. 2000 Dec 01; 246(1-2):69-77. PMID: 11121548.
    Citations: 3     Fields:    
  111. Roboz GJ, Dias S, Lam G, Lane WJ, Soignet SL, Warrell RP, Rafii S. Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis. Blood. 2000 Aug 15; 96(4):1525-30. PMID: 10942401.
    Citations: 44     Fields:    Translation:HumansCells
  112. Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane WJ, Williams M, Oz MC, Hicklin DJ, Witte L, Moore MA, Rafii S. Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood. 2000 Feb 01; 95(3):952-8. PMID: 10648408.
    Citations: 479     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.