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profileKurt D Christensen, Ph.D.

TitleInstructor in Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Genetics/Alumni Hall, Suite 301
41 Ave Louis Pasteur
Boston MA 02115
Phone617/264-5883
Fax617 2648795
vCardDownload vCard (login for email)

Collapse Overview 
Collapse overview
A future where genomic information is readily available is rapidly approaching. Whether this information improves public health by improving patient care and empowering prevention, or whether it diminishes public health by motivating unnecessary follow-up testing and screening is unclear. I use my training in health economics, biochemistry, public health, and health behavior and health education to address these issues by focusing on three interrelated questions: 1) How do patients and physicians respond, behaviorally and psychologically, to information generated from emerging genomic technologies like whole genome sequencing? 2) What is the healthcare service and economic impact of integrating genomics into the everyday practice of medicine? 3) How can programs be improved to maximize the benefits and minimize the harms of genomic testing? The answers to these questions are essential as healthcare providers and policymakers make decisions about how to offer and support new genomic services.


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Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
K01HG009173     (CHRISTENSEN, KURT DEREK)Sep 9, 2016 - Jun 30, 2021
NIH/NHGRI
Cost-effectiveness of Whole Genome Sequencing of Healthy Adults
Role: Principal Investigator

F32HG006993     (CHRISTENSEN, KURT DEREK)Aug 7, 2012 - Aug 6, 2014
NIH/NHGRI
Incidental Finding Preferences in Whole Genome Sequencing: A Randomized Trial
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Christensen KD, Uhlmann WR, Roberts JS, Linnenbringer E, Whitehouse PJ, Royal CDM, Obisesan TO, Cupples LA, Butson MB, Fasaye GA, Hiraki S, Chen CA, Siebert U, Cook-Deegan R, Green RC. A randomized controlled trial of disclosing genetic risk information for Alzheimer disease via telephone. Genet Med. 2017 Jul 20. PMID: 28726810.
    View in: PubMed
  2. Vassy JL, Christensen KD, Schonman EF, Blout CL, Robinson JO, Krier JB, Diamond PM, Lebo M, Machini K, Azzariti DR, Dukhovny D, Bates DW, MacRae CA, Murray MF, Rehm HL, McGuire AL, Green RC. The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients: A Pilot Randomized Trial. Ann Intern Med. 2017 Jun 27. PMID: 28654958.
    View in: PubMed
  3. Christensen KD, Savage SK, Huntington NL, Weitzman ER, Ziniel SI, Bacon PL, Cacioppo CN, Green RC, Holm IA. Preferences for the Return of Individual Results From Research on Pediatric Biobank Samples. J Empir Res Hum Res Ethics. 2017 Apr; 12(2):97-106. PMID: 28421887.
    View in: PubMed
  4. Jamal L Robinson JO Christensen KD Blumenthal-Barby J Slashinski MJ Perry DL Vassy JL Wycliff J Green RC McGuire AL. When bins blur together: patient perspectives on categories of returnable results from clinical whole genome sequencing. AJOB Empir Bioeth. 2017.
  5. Guan Y, Roter DL, Erby LH, Wolff JL, Gitlin LN, Roberts JS, Green RC, Christensen KD. Disclosing genetic risk of Alzheimer's disease to cognitively impaired patients and visit companions: Findings from the REVEAL Study. Patient Educ Couns. 2017 May; 100(5):927-935. PMID: 28012682.
    View in: PubMed
  6. Conway-Pearson LS, Christensen KD, Savage SK, Huntington NL, Weitzman ER, Ziniel SI, Bacon P, Cacioppo CN, Green RC, Holm IA. Family health history reporting is sensitive to small changes in wording. Genet Med. 2016 Dec; 18(12):1308-1311. PMID: 27148937.
    View in: PubMed
  7. Robinson JO, Carroll TM, Feuerman LZ, Perry DL, Hoffman-Andrews L, Walsh RC, Christensen KD, Green RC, McGuire AL. Participants and Study Decliners' Perspectives About the Risks of Participating in a Clinical Trial of Whole Genome Sequencing. J Empir Res Hum Res Ethics. 2016 Feb; 11(1):21-30. PMID: 26928896; PMCID: PMC4842131 [Available on 02/28/17].
  8. Baptista NM, Christensen KD, Carere DA, Broadley SA, Roberts JS, Green RC. Adopting genetics: motivations and outcomes of personal genomic testing in adult adoptees. Genet Med. 2016 Sep; 18(9):924-32. PMID: 26820063; PMCID: PMC4965328 [Available on 12/01/16].
  9. Christensen KD, Roberts JS, Whitehouse PJ, Royal CD, Obisesan TO, Cupples LA, Vernarelli JA, Bhatt DL, Linnenbringer E, Butson MB, Fasaye GA, Uhlmann WR, Hiraki S, Wang N, Cook-Deegan R, Green RC. Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial. Ann Intern Med. 2016 Feb 02; 164(3):155-63. PMID: 26810768; PMCID: PMC4979546.
  10. Lupo PJ, Robinson JO, Diamond PM, Jamal L, Danysh HE, Blumenthal-Barby J, Lehmann LS, Vassy JL, Christensen KD, Green RC, McGuire AL. Patients' perceived utility of whole-genome sequencing for their healthcare: findings from the MedSeq project. Per Med. 2016 Jan 01; 13(1):13-20. PMID: 27019659.
    View in: PubMed
  11. Christensen KD, Dukhovny D, Siebert U, Green RC. Assessing the Costs and Cost-Effectiveness of Genomic Sequencing. J Pers Med. 2015 Dec 10; 5(4):470-86. PMID: 26690481; PMCID: PMC4695866.
  12. Holm IA, Iles BR, Ziniel SI, Bacon PL, Savage SK, Christensen KD, Weitzman ER, Green RC, Huntington NL. Participant Satisfaction With a Preference-Setting Tool for the Return of Individual Research Results in Pediatric Genomic Research. J Empir Res Hum Res Ethics. 2015 Oct; 10(4):414-26. PMID: 26376753.
    View in: PubMed
  13. Christensen KD, Vassy JL, Jamal L, Lehmann LS, Slashinski MJ, Perry DL, Robinson JO, Blumenthal-Barby J, Feuerman LZ, Murray MF, Green RC, McGuire AL. Are physicians prepared for whole genome sequencing? a qualitative analysis. Clin Genet. 2016 Feb; 89(2):228-34. PMID: 26080898; PMCID: PMC4683111 [Available on 02/01/17].
  14. Robinson CL, Jouni H, Kruisselbrink TM, Austin EE, Christensen KD, Green RC, Kullo IJ. Disclosing genetic risk for coronary heart disease: effects on perceived personal control and genetic counseling satisfaction. Clin Genet. 2016 Feb; 89(2):251-7. PMID: 25708169.
    View in: PubMed
  15. Christensen KD, Roberts JS, Zikmund-Fisher BJ, Kardia SL, McBride CM, Linnenbringer E, Green RC. Associations between self-referral and health behavior responses to genetic risk information. Genome Med. 2015; 7(1):10. PMID: 25642295; PMCID: PMC4311425.
  16. Besser AG, Sanderson SC, Roberts JS, Chen CA, Christensen KD, Lautenbach DM, Cupples LA, Green RC. Factors affecting recall of different types of personal genetic information about Alzheimer's disease risk: the REVEAL study. Public Health Genomics. 2015; 18(2):78-86. PMID: 25634646; PMCID: PMC4470386.
  17. Vassy JL, Christensen KD, Slashinski MJ, Lautenbach DM, Raghavan S, Robinson JO, Blumenthal-Barby J, Feuerman LZ, Lehmann LS, Murray MF, Green RC, McGuire AL. 'Someday it will be the norm': physician perspectives on the utility of genome sequencing for patient care in the MedSeq Project. Per Med. 2015; 12(1):23-32. PMID: 25642274.
    View in: PubMed
  18. McLaughlin HM, Ceyhan-Birsoy O, Christensen KD, Kohane IS, Krier J, Lane WJ, Lautenbach D, Lebo MS, Machini K, MacRae CA, Azzariti DR, Murray MF, Seidman CE, Vassy JL, Green RC, Rehm HL. A systematic approach to the reporting of medically relevant findings from whole genome sequencing. BMC Med Genet. 2014 Dec 14; 15:134. PMID: 25714468; PMCID: PMC4342199.
  19. Green RC, Christensen KD, Cupples LA, Relkin NR, Whitehouse PJ, Royal CD, Obisesan TO, Cook-Deegan R, Linnenbringer E, Butson MB, Fasaye GA, Levinson E, Roberts JS. A randomized noninferiority trial of condensed protocols for genetic risk disclosure of Alzheimer's disease. Alzheimers Dement. 2015 Oct; 11(10):1222-30. PMID: 25499536; PMCID: PMC4461546 [Available on 10/01/16].
  20. Khan CM, Rini C, Bernhardt BA, Roberts JS, Christensen KD, Evans JP, Brothers KB, Roche MI, Berg JS, Henderson GE. How can psychological science inform research about genetic counseling for clinical genomic sequencing? J Genet Couns. 2015 Apr; 24(2):193-204. PMID: 25488723; PMCID: PMC4777349.
  21. Christensen KD, Kalia SS, Green RC. UpToDate, Raby BA (Ed). Incidental findings from genetic testing. 2014.
  22. Vassy JL, Lautenbach DM, McLaughlin HM, Kong SW, Christensen KD, Krier J, Kohane IS, Feuerman LZ, Blumenthal-Barby J, Roberts JS, Lehmann LS, Ho CY, Ubel PA, MacRae CA, Seidman CE, Murray MF, McGuire AL, Rehm HL, Green RC. The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine. Trials. 2014 Mar 20; 15:85. PMID: 24645908; PMCID: PMC4113228.
  23. Gray SW, Martins Y, Feuerman LZ, Bernhardt BA, Biesecker BB, Christensen KD, Joffe S, Rini C, Veenstra D, McGuire AL. Social and behavioral research in genomic sequencing: approaches from the Clinical Sequencing Exploratory Research Consortium Outcomes and Measures Working Group. Genet Med. 2014 Oct; 16(10):727-35. PMID: 24625446; PMCID: PMC4163120.
  24. Christensen KD, Green RC. How could disclosing incidental information from whole-genome sequencing affect patient behavior? Per Med. 2013 Jun; 10(4). PMID: 24319470.
    View in: PubMed
  25. Lautenbach DM, Christensen KD, Sparks JA, Green RC. Communicating genetic risk information for common disorders in the era of genomic medicine. Annu Rev Genomics Hum Genet. 2013; 14:491-513. PMID: 24003856; PMCID: PMC3862080.
  26. Terry SF, Christensen KD, Metosky S, Rudofsky G, Deignan KP, Martinez H, Johnson-Moore P, Citrin T. Community engagement about genetic variation research. Popul Health Manag. 2012 Apr; 15(2):78-89. PMID: 21815821; PMCID: PMC3363293.
  27. Roberts JS, Christensen KD, Green RC. Using Alzheimer's disease as a model for genetic risk disclosure: implications for personal genomics. Clin Genet. 2011 Nov; 80(5):407-14. PMID: 21696382; PMCID: PMC3191239.
  28. Christensen KD, Roberts JS, Uhlmann WR, Green RC. Changes to perceptions of the pros and cons of genetic susceptibility testing after APOE genotyping for Alzheimer disease risk. Genet Med. 2011 May; 13(5):409-14. PMID: 21270636; PMCID: PMC3170997.
  29. Hock KT, Christensen KD, Yashar BM, Roberts JS, Gollust SE, Uhlmann WR. Direct-to-consumer genetic testing: an assessment of genetic counselors' knowledge and beliefs. Genet Med. 2011 Apr; 13(4):325-32. PMID: 21233722; PMCID: PMC3804135.
  30. Christensen KD, Roberts JS, Shalowitz DI, Everett JN, Kim SY, Raskin L, Gruber SB. Disclosing individual CDKN2A research results to melanoma survivors: interest, impact, and demands on researchers. Cancer Epidemiol Biomarkers Prev. 2011 Mar; 20(3):522-9. PMID: 21307304; PMCID: PMC3833711.
  31. Roberts JS, Shalowitz DI, Christensen KD, Everett JN, Kim SY, Raskin L, Gruber SB. Returning individual research results: development of a cancer genetics education and risk communication protocol. J Empir Res Hum Res Ethics. 2010 Sep; 5(3):17-30. PMID: 20831418; PMCID: PMC3159194.
  32. Christensen KD, Jayaratne TE, Roberts JS, Kardia SL, Petty EM. Understandings of basic genetics in the United States: results from a national survey of black and white men and women. Public Health Genomics. 2010; 13(7-8):467-76. PMID: 20203477; PMCID: PMC3025896.
  33. Christensen KD, Roberts JS, Royal CD, Fasaye GA, Obisesan T, Cupples LA, Whitehouse PJ, Butson MB, Linnenbringer E, Relkin NR, Farrer L, Cook-Deegan R, Green RC. Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience. Genet Med. 2008 Mar; 10(3):207-14. PMID: 18344711; PMCID: PMC2483343.
  34. Harvey EK, Fogel CE, Peyrot M, Christensen KD, Terry SF, McInerney JD. Providers' knowledge of genetics: A survey of 5915 individuals and families with genetic conditions. Genet Med. 2007 May; 9(5):259-67. PMID: 17505202.
    View in: PubMed
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