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Melissa April St Hilaire, Ph.D.

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Worcester Polytechnic Institute, Worcester, MAB.S.05/2002Mathematical Sciences
Northeastern University, Boston, MAM.S.01/2006Bioinformatics
Boston University, Boston, MAPh.D.05/2012Cognitive and Neural Systems
Brigham and Women's Hospital/Harvard Medical School, Boston, MAPostdoc10/2015Circadian Physiology

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03AG071922 (ST HILAIRE, MELISSA APRIL) Aug 15, 2021 - May 31, 2023
    Validation of real-time field-based markers of circadian phase
    Role: Principal Investigator
  2. 80NSSC20K0576 (ST HILAIRE, MELISSA APRIL) Feb 1, 2020 - Jan 31, 2022
    Towards a real-time estimate of circadian phase during spaceflight
    Role: Principal Investigator
  3. R21NR018974 (ST HILAIRE, MELISSA APRIL) Sep 25, 2019 - Jul 31, 2021
    Urine metabolomics to estimate internal clock time
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. St Hilaire MA, Ámundadóttir ML, Rahman SA, Rajaratnam SMW, Rüger M, Brainard GC, Czeisler CA, Andersen M, Gooley JJ, Lockley SW. The spectral sensitivity of human circadian phase resetting and melatonin suppression to light changes dynamically with light duration. Proc Natl Acad Sci U S A. 2022 12 20; 119(51):e2205301119. PMID: 36508661.
    Citations:    Fields:    Translation:HumansCells
  2. Wang W, Yuan RK, Mitchell JF, Zitting KM, St Hilaire MA, Wyatt JK, Scheer FAJL, Wright KP, Brown EN, Ronda JM, Klerman EB, Duffy JF, Dijk DJ, Czeisler CA. Desynchronizing the sleep---wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period. Nat Protoc. 2022 Nov 14. PMID: 36376588.
    Citations: 1     Fields:    
  3. Rahman SA, Kent BA, Grant LK, Clark T, Hanifin JP, Barger LK, Czeisler CA, Brainard GC, St Hilaire MA, Lockley SW. Effects of dynamic lighting on circadian phase, self-reported sleep and performance during a 45-day space analog mission with chronic variable sleep deficiency. J Pineal Res. 2022 Nov; 73(4):e12826. PMID: 35996978.
    Citations:    Fields:    Translation:Humans
  4. Grant LK, St Hilaire MA, Heller JP, Heller RA, Lockley SW, Rahman SA. Impact of Upgraded Lighting on Falls in Care Home Residents. J Am Med Dir Assoc. 2022 10; 23(10):1698-1704.e2. PMID: 35850166.
    Citations:    Fields:    
  5. St Hilaire MA. Modeling (circadian). Prog Brain Res. 2022; 273(1):181-198. PMID: 35940716.
    Citations:    Fields:    Translation:Humans
  6. Rahman SA, St Hilaire MA, Grant LK, Barger LK, Brainard GC, Czeisler CA, Klerman EB, Lockley SW. Dynamic lighting schedules to facilitate circadian adaptation to shifted timing of sleep and wake. J Pineal Res. 2022 Aug; 73(1):e12805. PMID: 35501292.
    Citations:    Fields:    Translation:Humans
  7. Kent BA, Rahman SA, St Hilaire MA, Grant LK, Rüger M, Czeisler CA, Lockley SW. Publisher Correction: Circadian lipid and hepatic protein rhythms shift with a phase response curve different than melatonin. Nat Commun. 2022 Apr 20; 13(1):2241. PMID: 35444241; PMCID: PMC9021291.
    Citations:    Fields:    
  8. Kent BA, Rahman SA, St Hilaire MA, Grant LK, Rüger M, Czeisler CA, Lockley SW. Circadian lipid and hepatic protein rhythms shift with a phase response curve different than melatonin. Nat Commun. 2022 02 03; 13(1):681. PMID: 35115537; PMCID: PMC8814172.
    Citations: 1     Fields:    Translation:Humans
  9. Emens JS, St Hilaire MA, Klerman EB, Brotman DJ, Lin AL, Lewy AJ, Czeisler CA. Behaviorally and environmentally induced non-24-hour sleep-wake rhythm disorder in sighted patients. J Clin Sleep Med. 2022 Feb 01; 18(2):453-459. PMID: 34402783; PMCID: PMC8805008.
    Citations: 2     Fields:    Translation:Humans
  10. St Hilaire MA, Lockley SW. Measuring Urinary 6-Sulphatoxymelatonin in Humans. Methods Mol Biol. 2022; 2550:21-28. PMID: 36180673.
    Citations:    Fields:    Translation:Humans
  11. St Hilaire MA, Lockley SW. Measuring Dim Light Melatonin Onset in Humans. Methods Mol Biol. 2022; 2550:13-20. PMID: 36180672.
    Citations:    Fields:    Translation:Humans
  12. Grant LK, St Hilaire MA, Brainard GC, Czeisler CA, Lockley SW, Rahman SA. Endogenous circadian regulation and phase resetting of clinical metabolic biomarkers. J Pineal Res. 2021 Sep; 71(2):e12752. PMID: 34118084.
    Citations: 2     Fields:    Translation:Humans
  13. Brown LS, St Hilaire MA, McHill AW, Phillips AJK, Barger LK, Sano A, Czeisler CA, Doyle FJ, Klerman EB. A classification approach to estimating human circadian phase under circadian alignment from actigraphy and photometry data. J Pineal Res. 2021 Aug; 71(1):e12745. PMID: 34050968; PMCID: PMC8474125.
    Citations: 1     Fields:    Translation:Humans
  14. Rahman SA, Sullivan JP, Barger LK, St Hilaire MA, O'Brien CS, Stone KL, Phillips AJK, Klerman EB, Qadri S, Wright KP, Halbower AC, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Sanderson AL, Zee PC, Landrigan CP, Czeisler CA, Lockley SW. Extended Work Shifts and Neurobehavioral Performance in Resident-Physicians. Pediatrics. 2021 03; 147(3). PMID: 33619044; PMCID: PMC7919117.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  15. Cochrane C, Ba D, Klerman EB, St Hilaire MA. An ensemble mixed effects model of sleep loss and performance. J Theor Biol. 2021 01 21; 509:110497. PMID: 32966825; PMCID: PMC8631086.
    Citations: 2     Fields:    Translation:Humans
  16. St Hilaire MA, Lammers-van der Holst HM, Chinoy ED, Isherwood CM, Duffy JF. Prediction of individual differences in circadian adaptation to night work among older adults: application of a mathematical model using individual sleep-wake and light exposure data. Chronobiol Int. 2020 Sep-Oct; 37(9-10):1404-1411. PMID: 32893681.
    Citations: 4     Fields:    Translation:Humans
  17. Landrigan CP, Rahman SA, Sullivan JP, Vittinghoff E, Barger LK, Sanderson AL, Wright KP, O'Brien CS, Qadri S, St Hilaire MA, Halbower AC, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Zee PC, Lockley SW, Stone KL, Czeisler CA. Effect on Patient Safety of a Resident Physician Schedule without 24-Hour Shifts. N Engl J Med. 2020 06 25; 382(26):2514-2523. PMID: 32579812; PMCID: PMC7405505.
    Citations: 17     Fields:    Translation:Humans
  18. Klerman EB, Rahman SA, St Hilaire MA. What time is it? A tale of three clocks, with implications for personalized medicine. J Pineal Res. 2020 05; 68(4):e12646. PMID: 32155668.
    Citations: 2     Fields:    Translation:Humans
  19. Grant LK, Gooley JJ, St Hilaire MA, Rajaratnam SMW, Brainard GC, Czeisler CA, Lockley SW, Rahman SA. Menstrual phase-dependent differences in neurobehavioral performance: the role of temperature and the progesterone/estradiol ratio. Sleep. 2020 02 13; 43(2). PMID: 31670824.
    Citations: 2     Fields:    Translation:Humans
  20. St Hilaire MA, Kristal BS, Rahman SA, Sullivan JP, Quackenbush J, Duffy JF, Barger LK, Gooley JJ, Czeisler CA, Lockley SW. Using a Single Daytime Performance Test to Identify Most Individuals at High-Risk for Performance Impairment during Extended Wake. Sci Rep. 2019 11 13; 9(1):16681. PMID: 31723161.
    Citations: 7     Fields:    Translation:Humans
  21. Kronauer RE, St Hilaire MA, Rahman SA, Czeisler CA, Klerman EB. An Exploration of the Temporal Dynamics of Circadian Resetting Responses to Short- and Long-Duration Light Exposures: Cross-Species Consistencies and Differences. J Biol Rhythms. 2019 10; 34(5):497-514. PMID: 31368391; PMCID: PMC7363039.
    Citations: 6     Fields:    Translation:HumansAnimals
  22. Barger LK, Sullivan JP, Blackwell T, O'Brien CS, St Hilaire MA, Rahman SA, Phillips AJK, Qadri S, Wright KP, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Zee P, Sanderson AL, Halbower AC, Lockley SW, Landrigan CP, Stone KL, Czeisler CA. Effects on resident work hours, sleep duration, and work experience in a randomized order safety trial evaluating resident-physician schedules (ROSTERS). Sleep. 2019 08 01; 42(8). PMID: 31106381.
    Citations: 7     Fields:    Translation:Humans
  23. St Hilaire MA, Anderson C, Anwar J, Sullivan JP, Cade BE, Flynn-Evans EE, Czeisler CA, Lockley SW. Brief (<4 hr) sleep episodes are insufficient for restoring performance in first-year resident physicians working overnight extended-duration work shifts. Sleep. 2019 05 01; 42(5). PMID: 30794317; PMCID: PMC6519906.
    Citations: 5     Fields:    Translation:Humans
  24. Rahman SA, St Hilaire MA, Gronfier C, Chang AM, Santhi N, Czeisler CA, Klerman EB, Lockley SW. Functional decoupling of melatonin suppression and circadian phase resetting in humans. J Physiol. 2018 06; 596(11):2147-2157. PMID: 29707782; PMCID: PMC5983136.
    Citations: 18     Fields:    Translation:Humans
  25. St Hilaire MA, Rahman SA, Gooley JJ, Witt-Enderby PA, Lockley SW. Relationship between melatonin and bone resorption rhythms in premenopausal women. J Bone Miner Metab. 2019 Jan; 37(1):60-71. PMID: 29318392.
    Citations: 8     Fields:    Translation:Humans
  26. Cohen S, Fulcher BD, Rajaratnam SMW, Conduit R, Sullivan JP, St Hilaire MA, Phillips AJK, Loddenkemper T, Kothare SV, McConnell K, Braga-Kenyon P, Ahearn W, Shlesinger A, Potter J, Bird F, Cornish KM, Lockley SW. Sleep patterns predictive of daytime challenging behavior in individuals with low-functioning autism. Autism Res. 2018 02; 11(2):391-403. PMID: 29197172.
    Citations: 24     Fields:    Translation:Humans
  27. Rahman SA, St Hilaire MA, Lockley SW. The effects of spectral tuning of evening ambient light on melatonin suppression, alertness and sleep. Physiol Behav. 2017 Aug 01; 177:221-229. PMID: 28472667; PMCID: PMC5536841.
    Citations: 34     Fields:    Translation:Humans
  28. Rahman SA, St Hilaire MA, Chang AM, Santhi N, Duffy JF, Kronauer RE, Czeisler CA, Lockley SW, Klerman EB. Circadian phase resetting by a single short-duration light exposure. JCI Insight. 2017 04 06; 2(7):e89494. PMID: 28405608.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  29. St Hilaire MA, Rüger M, Fratelli F, Hull JT, Phillips AJ, Lockley SW. Modeling Neurocognitive Decline and Recovery During Repeated Cycles of Extended Sleep and Chronic Sleep Deficiency. Sleep. 2017 Jan 01; 40(1). PMID: 28364449.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  30. St Hilaire MA, Rüger M, Fratelli F, Hull JT, Phillips AJ, Lockley SW. Modeling neurocognitive decline and recovery during repeated cycles of extended sleep and chronic sleep deficiency. Sleep. 2016 Sep 26. PMID: 27692052.
  31. Grima NA, Ponsford JL, St Hilaire MA, Mansfield D, Rajaratnam SM. Circadian Melatonin Rhythm Following Traumatic Brain Injury. Neurorehabil Neural Repair. 2016 11; 30(10):972-977. PMID: 27221043.
    Citations: 21     Fields:    Translation:Humans
  32. Lane JM, Chang AM, Bjonnes AC, Aeschbach D, Anderson C, Cade BE, Cain SW, Czeisler CA, Gharib SA, Gooley JJ, Gottlieb DJ, Grant SF, Klerman EB, Lauderdale DS, Lockley SW, Munch M, Patel S, Punjabi NM, Rajaratnam SM, Rueger M, St Hilaire MA, Santhi N, Scheuermaier K, Van Reen E, Zee PC, Shea SA, Duffy JF, Buxton OM, Redline S, Scheer FA, Saxena R. Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology. Diabetes. 2016 06; 65(6):1741-51. PMID: 26868293; PMCID: PMC4878414.
    Citations: 33     Fields:    Translation:Humans
  33. St Hilaire MA, Lockley SW. Caffeine does not entrain the circadian clock but improves daytime alertness in blind patients with non-24-hour rhythms. Sleep Med. 2015 Jun; 16(6):800-4. PMID: 25891543; PMCID: PMC4465963.
    Citations: 5     Fields:    Translation:Humans
  34. Breslow ER, Phillips AJ, Huang JM, St Hilaire MA, Klerman EB. A mathematical model of the circadian phase-shifting effects of exogenous melatonin. J Biol Rhythms. 2013 Feb; 28(1):79-89. PMID: 23382594.
    Citations: 8     Fields:    Translation:HumansCells
  35. Rüger M, St Hilaire MA, Brainard GC, Khalsa SB, Kronauer RE, Czeisler CA, Lockley SW. Human phase response curve to a single 6.5 h pulse of short-wavelength light. J Physiol. 2013 Jan 01; 591(1):353-63. PMID: 23090946.
    Citations: 46     Fields:    Translation:Humans
  36. Gooley JJ, Ho Mien I, St Hilaire MA, Yeo SC, Chua EC, van Reen E, Hanley CJ, Hull JT, Czeisler CA, Lockley SW. Melanopsin and rod-cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans. J Neurosci. 2012 Oct 10; 32(41):14242-53. PMID: 23055493.
    Citations: 85     Fields:    Translation:HumansCells
  37. St Hilaire MA, Sullivan JP, Anderson C, Cohen DA, Barger LK, Lockley SW, Klerman EB. Classifying performance impairment in response to sleep loss using pattern recognition algorithms on single session testing. Accid Anal Prev. 2013 Jan; 50:992-1002. PMID: 22959616.
    Citations: 2     Fields:    Translation:Humans
  38. St Hilaire MA, Gooley JJ, Khalsa SB, Kronauer RE, Czeisler CA, Lockley SW. Human phase response curve to a 1 h pulse of bright white light. J Physiol. 2012 Jul 01; 590(13):3035-45. PMID: 22547633.
    Citations: 79     Fields:    Translation:Humans
  39. Chang AM, Santhi N, St Hilaire M, Gronfier C, Bradstreet DS, Duffy JF, Lockley SW, Kronauer RE, Czeisler CA. Human responses to bright light of different durations. J Physiol. 2012 Jul 01; 590(13):3103-12. PMID: 22526883.
    Citations: 78     Fields:    Translation:Humans
  40. Klerman H, St Hilaire MA, Kronauer RE, Gooley JJ, Gronfier C, Hull JT, Lockley SW, Santhi N, Wang W, Klerman EB. Analysis method and experimental conditions affect computed circadian phase from melatonin data. PLoS One. 2012; 7(4):e33836. PMID: 22511928.
    Citations: 10     Fields:    Translation:Humans
  41. St Hilaire MA, Gronfier C, Zeitzer JM, Klerman EB. A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemaker. J Pineal Res. 2007 Oct; 43(3):294-304. PMID: 17803528; PMCID: PMC2714090.
    Citations: 19     Fields:    Translation:Humans
  42. St Hilaire MA, Klerman EB, Khalsa SB, Wright KP, Czeisler CA, Kronauer RE. Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker. J Theor Biol. 2007 Aug 21; 247(4):583-99. PMID: 17531270; PMCID: PMC3123888.
    Citations: 30     Fields:    Translation:HumansAnimals
  43. Klerman EB, St Hilaire M. On mathematical modeling of circadian rhythms, performance, and alertness. J Biol Rhythms. 2007 Apr; 22(2):91-102. PMID: 17440211.
    Citations: 13     Fields:    Translation:Humans
  44. Indic P, Forger DB, St Hilaire MA, Dean DA, Brown EN, Kronauer RE, Klerman EB, Jewett ME. Comparison of amplitude recovery dynamics of two limit cycle oscillator models of the human circadian pacemaker. Chronobiol Int. 2005; 22(4):613-29. PMID: 16147894; PMCID: PMC3797655.
    Citations: 6     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.