Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Douglas A. Melton, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. UC4DK104218 (GREINER, DALE LESLIE) Sep 25, 2014 - Jun 30, 2019
    Humanized Mouse Avatars for T1D
    Role: Co-Principal Investigator
  2. UC4DK104159 (MELTON, DOUGLAS A) Sep 23, 2014 - Aug 31, 2017
    Biomarkers for Diabetes Using Stem Cell-Derived Beta Cells
    Role: Principal Investigator
  3. UC4DK104165 (MELTON, DOUGLAS A) Sep 20, 2014 - Jun 30, 2019
    Islet on a Chip
    Role: Principal Investigator
  4. R24DK092758 (MELTON, DOUGLAS A) Sep 1, 2011 - Aug 31, 2013
    Reconstruction of Human Type 1 Diabetes in Mice
    Role: Principal Investigator
  5. RC4DK090781 (MELTON, DOUGLAS A) Sep 25, 2010 - Sep 30, 2013
    Identification of Genes and Compounds That Control Beta Cell Replication
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Harvard Stem Cell Institute - Research opportunities (1)
Melton Lab - iPS cells (21)

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Veres A, Faust AL, Bushnell HL, Engquist EN, Kenty JH, Harb G, Poh YC, Sintov E, Gürtler M, Pagliuca FW, Peterson QP, Melton DA. Charting cellular identity during human in vitro ß-cell differentiation. Nature. 2019 May; 569(7756):368-373. PMID: 31068696.
  2. Han X, Wang M, Duan S, Franco PJ, Kenty JH, Hedrick P, Xia Y, Allen A, Ferreira LMR, Strominger JL, Melton DA, Meissner TB, Cowan CA. Generation of hypoimmunogenic human pluripotent stem cells. Proc Natl Acad Sci U S A. 2019 Apr 30. PMID: 31040209.
  3. Rosado-Olivieri EA, Anderson K, Kenty JH, Melton DA. YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing ß cells. Nat Commun. 2019 04 01; 10(1):1464. PMID: 30931946.
  4. Alagpulinsa DA, Cao JJL, Driscoll RK, Sîrbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns TA, Markmann JF, Melton DA, Poznansky MC. Alginate-microencapsulation of human stem cell-derived ß cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression. Am J Transplant. 2019 Feb 12. PMID: 30748094.
  5. Sharon N, Chawla R, Mueller J, Vanderhooft J, Whitehorn LJ, Rosenthal B, Gürtler M, Estanboulieh RR, Shvartsman D, Gifford DK, Trapnell C, Melton D. A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets. Cell. 2019 Feb 07; 176(4):790-804.e13. PMID: 30661759.
    Citations:    Fields:    
  6. Tsai SL, Baselga-Garriga C, Melton DA. Blastemal progenitors modulate immune signaling during early limb regeneration. Development. 2019 Jan 02; 146(1). PMID: 30602532.
    Citations:    Fields:    
  7. Mahmoud AI, Galdos FX, Dinan KA, Jedrychowski MP, Davis JC, Vujic A, Rachmin I, Shigley C, Pancoast JR, Lee S, Hollister-Lock J, MacGillivray CM, Gygi SP, Melton DA, Weir GC, Lee RT. Apolipoprotein E is a pancreatic extracellular factor that maintains mature ß-cell gene expression. PLoS One. 2018; 13(10):e0204595. PMID: 30303984.
    Citations:    Fields:    
  8. Zhou Q, Melton DA. Author Correction: Pancreas regeneration. Nature. 2018 08; 560(7720):E34. PMID: 29925956.
    Citations:    Fields:    
  9. Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A. Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation. 2018 08; 102(8):1223-1229. PMID: 29781950.
    Citations:    Fields:    
  10. Zhou Q, Melton DA. Pancreas regeneration. Nature. 2018 05; 557(7705):351-358. PMID: 29769672.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Ma H, Wert KJ, Shvartsman D, Melton DA, Jaenisch R. Establishment of human pluripotent stem cell-derived pancreatic ß-like cells in the mouse pancreas. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):3924-3929. PMID: 29599125.
    Citations:    Fields:    Translation:HumansAnimalsCells
  12. Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA. Corrigendum: Generation of stem cell-derived ß-cells from patients with type 1 diabetes. Nat Commun. 2016 08 04; 7:12379. PMID: 27487970.
    Citations: 1     Fields:    
  13. Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA. Generation of stem cell-derived ß-cells from patients with type 1 diabetes. Nat Commun. 2016 05 10; 7:11463. PMID: 27163171.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  14. Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q. Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 03; 18(3):410-21. PMID: 26908146.
    Citations: 18     Fields:    Translation:AnimalsCells
  15. Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG. Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med. 2016 Mar; 22(3):306-11. PMID: 26808346.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  16. Melton DA. Applied Developmental Biology: Making Human Pancreatic Beta Cells for Diabetics. Curr Top Dev Biol. 2016; 117:65-73. PMID: 26969972.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  17. Ben-Zvi D, Barrandon O, Hadley S, Blum B, Peterson QP, Melton DA. Angptl4 links a-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15498-503. PMID: 26621734.
    Citations: 8     Fields:    Translation:AnimalsCells
  18. Chetty S, Engquist EN, Mehanna E, Lui KO, Tsankov AM, Melton DA. A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation. J Cell Biol. 2015 Sep 28; 210(7):1257-68. PMID: 26416968.
    Citations: 4     Fields:    Translation:HumansCells
  19. Kenty JH, Melton DA. Testing pancreatic islet function at the single cell level by calcium influx with associated marker expression. PLoS One. 2015; 10(4):e0122044. PMID: 25853429.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  20. Ben-Zvi D, Melton DA. Modeling human nutrition using human embryonic stem cells. Cell. 2015 Mar 26; 161(1):12-17. PMID: 25815980.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  21. Pagliuca FW, Millman JR, Gürtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D, Melton DA. Generation of functional human pancreatic ß cells in vitro. Cell. 2014 Oct 09; 159(2):428-39. PMID: 25303535.
    Citations: 273     Fields:    Translation:HumansAnimalsCells
  22. Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DA. Reversal of ß cell de-differentiation by a small molecule inhibitor of the TGFß pathway. Elife. 2014 Sep 16; 3:e02809. PMID: 25233132.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  23. Hrvatin S, Deng F, O'Donnell CW, Gifford DK, Melton DA. MARIS: method for analyzing RNA following intracellular sorting. PLoS One. 2014; 9(3):e89459. PMID: 24594682.
    Citations: 33     Fields:    Translation:HumansCells
  24. Hrvatin S, O'Donnell CW, Deng F, Millman JR, Pagliuca FW, DiIorio P, Rezania A, Gifford DK, Melton DA. Differentiated human stem cells resemble fetal, not adult, ß cells. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3038-43. PMID: 24516164.
    Citations: 55     Fields:    Translation:HumansCells
  25. Li W, Nakanishi M, Zumsteg A, Shear M, Wright C, Melton DA, Zhou Q. In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. Elife. 2014 Jan 01; 3:e01846. PMID: 24714494.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  26. Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA. Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells. 2013 Dec; 31(12):2833-41. PMID: 23765749.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  27. Pagliuca FW, Melton DA. How to make a functional ß-cell. Development. 2013 Jun; 140(12):2472-83. PMID: 23715541.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  28. Yi P, Park JS, Melton DA. Betatrophin: a hormone that controls pancreatic ß cell proliferation. Cell. 2013 May 09; 153(4):747-58. PMID: 23623304.
    Citations: 152     Fields:    Translation:HumansAnimalsCells
  29. Chetty S, Pagliuca FW, Honore C, Kweudjeu A, Rezania A, Melton DA. A simple tool to improve pluripotent stem cell differentiation. Nat Methods. 2013 Jun; 10(6):553-6. PMID: 23584186.
    Citations: 50     Fields:    Translation:HumansCells
  30. Chen AE, Borowiak M, Sherwood RI, Kweudjeu A, Melton DA. Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation. Development. 2013 Feb 01; 140(3):675-86. PMID: 23293299.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  31. Carolan PJ, Melton DA. New findings in pancreatic and intestinal endocrine development to advance regenerative medicine. Curr Opin Endocrinol Diabetes Obes. 2013 Feb; 20(1):1-7. PMID: 23249759.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  32. Sneddon JB, Borowiak M, Melton DA. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature. 2012 Nov 29; 491(7426):765-8. PMID: 23041930.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  33. Blum B, Hrvatin S, Schuetz C, Bonal C, Rezania A, Melton DA. Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. Nat Biotechnol. 2012 02 26; 30(3):261-4. PMID: 22371083.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  34. Annes JP, Ryu JH, Lam K, Carolan PJ, Utz K, Hollister-Lock J, Arvanites AC, Rubin LL, Weir G, Melton DA. Adenosine kinase inhibition selectively promotes rodent and porcine islet ß-cell replication. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3915-20. PMID: 22345561.
    Citations: 41     Fields:    Translation:AnimalsCells
  35. Egli D, Chen AE, Saphier G, Ichida J, Fitzgerald C, Go KJ, Acevedo N, Patel J, Baetscher M, Kearns WG, Goland R, Leibel RL, Melton DA, Eggan K. Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun. 2011 Oct 04; 2:488. PMID: 21971503.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  36. Melton DA. Using stem cells to study and possibly treat type 1 diabetes. Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12; 366(1575):2307-11. PMID: 21727136.
    Citations: 11     Fields:    Translation:HumansCells
  37. Sherwood RI, Maehr R, Mazzoni EO, Melton DA. Wnt signaling specifies and patterns intestinal endoderm. Mech Dev. 2011 Sep-Dec; 128(7-10):387-400. PMID: 21854845.
    Citations: 39     Fields:    Translation:AnimalsCells
  38. Cohen DE, Melton D. Turning straw into gold: directing cell fate for regenerative medicine. Nat Rev Genet. 2011 Apr; 12(4):243-52. PMID: 21386864.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  39. Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 2010 Feb 01; 24(3):312-26. PMID: 20123909.
    Citations: 96     Fields:    Translation:AnimalsCells
  40. Borowiak M, Melton DA. How to make beta cells? Curr Opin Cell Biol. 2009 Dec; 21(6):727-32. PMID: 19781928.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  41. Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA. Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15768-73. PMID: 19720998.
    Citations: 191     Fields:    Translation:HumansCells
  42. Guseh JS, Bores SA, Stanger BZ, Zhou Q, Anderson WJ, Melton DA, Rajagopal J. Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development. 2009 May; 136(10):1751-9. PMID: 19369400.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  43. Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell. 2009 Apr 03; 4(4):348-58. PMID: 19341624.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  44. Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr; 5(4):258-65. PMID: 19287398.
    Citations: 155     Fields:    Translation:HumansAnimalsCells
  45. Brennand K, Melton D. Slow and steady is the key to beta-cell replication. J Cell Mol Med. 2009 Mar; 13(3):472-87. PMID: 19379145.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  46. Chen AE, Egli D, Niakan K, Deng J, Akutsu H, Yamaki M, Cowan C, Fitz-Gerald C, Zhang K, Melton DA, Eggan K. Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell. 2009 Feb 06; 4(2):103-6. PMID: 19200798.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  47. Sherwood RI, Chen TY, Melton DA. Transcriptional dynamics of endodermal organ formation. Dev Dyn. 2009 Jan; 238(1):29-42. PMID: 19097184.
    Citations: 65     Fields:    Translation:AnimalsCells
  48. Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, Muhlestein W, Melton DA. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol. 2008 Nov; 26(11):1269-75. PMID: 18849973.
    Citations: 452     Fields:    Translation:HumansAnimalsCells
  49. Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, Melton DA. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol. 2008 Jul; 26(7):795-7. PMID: 18568017.
    Citations: 528     Fields:    Translation:AnimalsCells
  50. Rajagopal J, Carroll TJ, Guseh JS, Bores SA, Blank LJ, Anderson WJ, Yu J, Zhou Q, McMahon AP, Melton DA. Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development. 2008 May; 135(9):1625-34. PMID: 18367557.
    Citations: 66     Fields:    Translation:AnimalsCells
  51. Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien KR, Melton DA. Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol. 2008 Mar; 26(3):313-5. PMID: 18278034.
    Citations: 275     Fields:    Translation:HumansCells
  52. Anderson WJ, Zhou Q, Alcalde V, Kaneko OF, Blank LJ, Sherwood RI, Guseh JS, Rajagopal J, Melton DA. Genetic targeting of the endoderm with claudin-6CreER. Dev Dyn. 2008 Feb; 237(2):504-12. PMID: 18213590.
    Citations: 20     Fields:    Translation:Animals
  53. Zhou Q, Melton DA. Pathways to new beta cells. Cold Spring Harb Symp Quant Biol. 2008; 73:175-81. PMID: 19478324.
    Citations: 9     Fields:    Translation:HumansCells
  54. Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA. A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell. 2007 Jul; 13(1):103-14. PMID: 17609113.
    Citations: 201     Fields:    Translation:AnimalsCells
  55. Brennand K, Huangfu D, Melton D. All beta cells contribute equally to islet growth and maintenance. PLoS Biol. 2007 Jul; 5(7):e163. PMID: 17535113.
    Citations: 90     Fields:    Translation:AnimalsCells
  56. Stanger BZ, Tanaka AJ, Melton DA. Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature. 2007 Feb 22; 445(7130):886-91. PMID: 17259975.
    Citations: 123     Fields:    Translation:AnimalsCells
  57. Sherwood RI, Jitianu C, Cleaver O, Shaywitz DA, Lamenzo JO, Chen AE, Golub TR, Melton DA. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Dev Biol. 2007 Apr 15; 304(2):541-55. PMID: 17328885.
    Citations: 54     Fields:    Translation:AnimalsCells
  58. Greenwood AL, Li S, Jones K, Melton DA. Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate. Mech Dev. 2007 Feb; 124(2):97-107. PMID: 17196797.
    Citations: 27     Fields:    
  59. Melton DA. Reversal of type 1 diabetes in mice. N Engl J Med. 2006 Jul 06; 355(1):89-90. PMID: 16823003.
    Citations: 3     Fields:    Translation:AnimalsCells
  60. Nikolova G, Jabs N, Konstantinova I, Domogatskaya A, Tryggvason K, Sorokin L, Fässler R, Gu G, Gerber HP, Ferrara N, Melton DA, Lammert E. The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell. 2006 Mar; 10(3):397-405. PMID: 16516842.
    Citations: 146     Fields:    Translation:AnimalsCells
  61. Akutsu H, Cowan CA, Melton D. Human embryonic stem cells. Methods Enzymol. 2006; 418:78-92. PMID: 17141030.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  62. Murtaugh LC, Law AC, Dor Y, Melton DA. Beta-catenin is essential for pancreatic acinar but not islet development. Development. 2005 Nov; 132(21):4663-74. PMID: 16192304.
    Citations: 91     Fields:    Translation:AnimalsCells
  63. Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005 Sep; 8(3):185-95. PMID: 16169464.
    Citations: 120     Fields:    Translation:Animals
  64. Cowan CA, Atienza J, Melton DA, Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science. 2005 Aug 26; 309(5739):1369-73. PMID: 16123299.
    Citations: 222     Fields:    Translation:HumansAnimalsCells
  65. Stanger BZ, Datar R, Murtaugh LC, Melton DA. Direct regulation of intestinal fate by Notch. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12443-8. PMID: 16107537.
    Citations: 105     Fields:    Translation:AnimalsCells
  66. Melton DA, Daley GQ, Jennings CG. Altered nuclear transfer in stem-cell research - a flawed proposal. N Engl J Med. 2004 Dec 30; 351(27):2791-2. PMID: 15625329.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  67. Dor Y, Melton DA. How important are adult stem cells for tissue maintenance? Cell Cycle. 2004 Sep; 3(9):1104-6. PMID: 15326371.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  68. Annerén C, Cowan CA, Melton DA. The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. J Biol Chem. 2004 Jul 23; 279(30):31590-8. PMID: 15148312.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  69. Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004 May 06; 429(6987):41-6. PMID: 15129273.
    Citations: 676     Fields:    Translation:AnimalsCells
  70. Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, Zucker JP, Wang S, Morton CC, McMahon AP, Powers D, Melton DA. Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med. 2004 Mar 25; 350(13):1353-6. PMID: 14999088.
    Citations: 226     Fields:    Translation:HumansCells
  71. Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA. Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development. 2004 Jan; 131(1):165-79. PMID: 14660441.
    Citations: 86     Fields:    Translation:AnimalsCells
  72. Murtaugh LC, Stanger BZ, Kwan KM, Melton DA. Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):14920-5. PMID: 14657333.
    Citations: 308     Fields:    Translation:AnimalsCells
  73. Kumar M, Melton D. Pancreas specification: a budding question. Curr Opin Genet Dev. 2003 Aug; 13(4):401-7. PMID: 12888014.
    Citations: 17     Fields:    Translation:HumansCells
  74. Kumar M, Jordan N, Melton D, Grapin-Botton A. Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev Biol. 2003 Jul 01; 259(1):109-22. PMID: 12812792.
    Citations: 56     Fields:    Translation:Animals
  75. Cleaver O, Melton DA. Endothelial signaling during development. Nat Med. 2003 Jun; 9(6):661-8. PMID: 12778164.
    Citations: 118     Fields:    Translation:HumansAnimalsCells
  76. Chiang MK, Melton DA. Single-cell transcript analysis of pancreas development. Dev Cell. 2003 Mar; 4(3):383-93. PMID: 12636919.
    Citations: 62     Fields:    Translation:AnimalsCells
  77. Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA. Insulin staining of ES cell progeny from insulin uptake. Science. 2003 Jan 17; 299(5605):363. PMID: 12532008.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  78. Lammert E, Cleaver O, Melton D. Role of endothelial cells in early pancreas and liver development. Mech Dev. 2003 Jan; 120(1):59-64. PMID: 12490296.
    Citations: 58     Fields:    Translation:HumansAnimals
  79. Murtaugh LC, Melton DA. Genes, signals, and lineages in pancreas development. Annu Rev Cell Dev Biol. 2003; 19:71-89. PMID: 14570564.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  80. Gu G, Brown JR, Melton DA. Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev. 2003 Jan; 120(1):35-43. PMID: 12490294.
    Citations: 71     Fields:    Translation:AnimalsCells
  81. Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA. "Stemness": transcriptional profiling of embryonic and adult stem cells. Science. 2002 Oct 18; 298(5593):597-600. PMID: 12228720.
    Citations: 424     Fields:    Translation:AnimalsCells
  82. Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 2002 May; 129(10):2447-57. PMID: 11973276.
    Citations: 500     Fields:    Translation:AnimalsCells
  83. Fishman MP, Melton DA. Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells. Int J Dev Biol. 2002 Mar; 46(2):201-7. PMID: 11934148.
    Citations: 8     Fields:    Translation:AnimalsCells
  84. Lammert E, Cleaver O, Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science. 2001 Oct 19; 294(5542):564-7. PMID: 11577200.
    Citations: 251     Fields:    Translation:AnimalsCells
  85. Grapin-Botton A, Majithia AR, Melton DA. Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev. 2001 Feb 15; 15(4):444-54. PMID: 11230152.
    Citations: 74     Fields:    Translation:AnimalsCells
  86. Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA. Regulation of pancreas development by hedgehog signaling. Development. 2000 Nov; 127(22):4905-13. PMID: 11044404.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  87. Schuldiner M, Yanuka O, Itskovitz-Eldor J, Melton DA, Benvenisty N. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21):11307-12. PMID: 11027332.
    Citations: 167     Fields:    Translation:HumansCells
  88. Kelly OG, Melton DA. Development of the pancreas in Xenopus laevis. Dev Dyn. 2000 Aug; 218(4):615-27. PMID: 10906780.
    Citations: 19     Fields:    Translation:Animals
  89. Lammert E, Brown J, Melton DA. Notch gene expression during pancreatic organogenesis. Mech Dev. 2000 Jun; 94(1-2):199-203. PMID: 10842072.
    Citations: 33     Fields:    Translation:Animals
  90. Ramalho-Santos M, Melton DA, McMahon AP. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development. 2000 Jun; 127(12):2763-72. PMID: 10821773.
    Citations: 205     Fields:    Translation:HumansAnimals
  91. Wells JM, Melton DA. Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development. 2000 Apr; 127(8):1563-72. PMID: 10725233.
    Citations: 87     Fields:    Translation:AnimalsCells
  92. Grapin-Botton A, Melton DA. Endoderm development: from patterning to organogenesis. Trends Genet. 2000 Mar; 16(3):124-30. PMID: 10689353.
    Citations: 45     Fields:    Translation:Animals
  93. Hebrok M, Kim SK, Melton DA. Screening for novel pancreatic genes expressed during embryogenesis. Diabetes. 1999 Aug; 48(8):1550-6. PMID: 10426372.
    Citations: 1     Fields:    Translation:AnimalsCells
  94. Wells JM, Melton DA. Vertebrate endoderm development. Annu Rev Cell Dev Biol. 1999; 15:393-410. PMID: 10611967.
    Citations: 109     Fields:    Translation:HumansAnimals
  95. Kim SK, Melton DA. Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13036-41. PMID: 9789036.
    Citations: 53     Fields:    Translation:AnimalsCells
  96. Henry GL, Melton DA. Mixer, a homeobox gene required for endoderm development. Science. 1998 Jul 03; 281(5373):91-6. PMID: 9651252.
    Citations: 35     Fields:    Translation:Animals
  97. Joseph EM, Melton DA. Mutant Vg1 ligands disrupt endoderm and mesoderm formation in Xenopus embryos. Development. 1998 Jul; 125(14):2677-85. PMID: 9636082.
    Citations: 9     Fields:    Translation:AnimalsCells
  98. Hebrok M, Kim SK, Melton DA. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 1998 Jun 01; 12(11):1705-13. PMID: 9620856.
    Citations: 110     Fields:    Translation:Animals
  99. Kim SK, Hebrok M, Melton DA. Notochord to endoderm signaling is required for pancreas development. Development. 1997 Nov; 124(21):4243-52. PMID: 9334273.
    Citations: 76     Fields:    Translation:AnimalsCells
  100. Joseph EM, Melton DA. Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer. Dev Biol. 1997 Apr 15; 184(2):367-72. PMID: 9133442.
    Citations: 18     Fields:    Translation:AnimalsCells
  101. Melton D. Signals for tissue induction and organ formation in vertebrate embryos. Harvey Lect. 1997-1998; 93:49-64. PMID: 10941418.
    Citations: 3     Fields:    Translation:AnimalsCells
  102. Kim SK, Hebrok M, Melton DA. Pancreas development in the chick embryo. Cold Spring Harb Symp Quant Biol. 1997; 62:377-83. PMID: 9598372.
    Citations: 17     Fields:    Translation:AnimalsCells
  103. Reilly KM, Melton DA. Short-range signaling by candidate morphogens of the TGF beta family and evidence for a relay mechanism of induction. Cell. 1996 Sep 06; 86(5):743-54. PMID: 8797821.
    Citations: 14     Fields:    Translation:AnimalsCells
  104. Klein PS, Melton DA. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8455-9. PMID: 8710892.
    Citations: 628     Fields:    Translation:AnimalsCells
  105. Newfeld SJ, Chartoff EH, Graff JM, Melton DA, Gelbart WM. Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells. Development. 1996 Jul; 122(7):2099-108. PMID: 8681791.
    Citations: 35     Fields:    Translation:AnimalsCells
  106. Graff JM, Bansal A, Melton DA. Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily. Cell. 1996 May 17; 85(4):479-87. PMID: 8653784.
    Citations: 52     Fields:    Translation:AnimalsCells
  107. Dohrmann CE, Kessler DS, Melton DA. Induction of axial mesoderm by zDVR-1, the zebrafish orthologue of Xenopus Vg1. Dev Biol. 1996 Apr 10; 175(1):108-17. PMID: 8608857.
    Citations: 8     Fields:    Translation:AnimalsCells
  108. Henry GL, Brivanlou IH, Kessler DS, Hemmati-Brivanlou A, Melton DA. TGF-beta signals and a pattern in Xenopus laevis endodermal development. Development. 1996 Mar; 122(3):1007-15. PMID: 8631246.
    Citations: 22     Fields:    Translation:AnimalsCells
  109. Kelly OG, Melton DA. Induction and patterning of the vertebrate nervous system. Trends Genet. 1995 Jul; 11(7):273-8. PMID: 7482777.
    Citations: 1     Fields:    Translation:AnimalsCells
  110. Kessler DS, Melton DA. Induction of dorsal mesoderm by soluble, mature Vg1 protein. Development. 1995 Jul; 121(7):2155-64. PMID: 7635059.
    Citations: 16     Fields:    Translation:Animals
  111. Klein PS, Melton DA. Translational control of activin in Xenopus laevis embryos. Dev Genet. 1995; 17(1):55-64. PMID: 7554495.
    Citations: 1     Fields:    Translation:AnimalsCells
  112. Kessler DS, Melton DA. Vertebrate embryonic induction: mesodermal and neural patterning. Science. 1994 Oct 28; 266(5185):596-604. PMID: 7939714.
    Citations: 28     Fields:    Translation:Animals
  113. Graff JM, Thies RS, Song JJ, Celeste AJ, Melton DA. Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell. 1994 Oct 07; 79(1):169-79. PMID: 7522972.
    Citations: 59     Fields:    Translation:AnimalsCells
  114. Klein PS, Melton DA. Induction of mesoderm in Xenopus laevis embryos by translation initiation factor 4E. Science. 1994 Aug 05; 265(5173):803-6. PMID: 8047887.
    Citations: 8     Fields:    Translation:AnimalsCells
  115. Wilson PA, Melton DA. Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr Biol. 1994 Aug 01; 4(8):676-86. PMID: 7953553.
    Citations: 45     Fields:    Translation:AnimalsCells
  116. Klein PS, Melton DA. Hormonal regulation of embryogenesis: the formation of mesoderm in Xenopus laevis. Endocr Rev. 1994 Jun; 15(3):326-41. PMID: 8076585.
    Citations: 5     Fields:    Translation:Animals
  117. Hemmati-Brivanlou A, Melton DA. Inhibition of activin receptor signaling promotes neuralization in Xenopus. Cell. 1994 Apr 22; 77(2):273-81. PMID: 8168134.
    Citations: 62     Fields:    Translation:AnimalsCells
  118. Hemmati-Brivanlou A, Kelly OG, Melton DA. Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell. 1994 Apr 22; 77(2):283-95. PMID: 8168135.
    Citations: 84     Fields:    Translation:AnimalsCells
  119. Ku M, Melton DA. Xwnt-11: a maternally expressed Xenopus wnt gene. Development. 1993 Dec; 119(4):1161-73. PMID: 8306880.
    Citations: 40     Fields:    Translation:AnimalsCells
  120. Thomsen GH, Melton DA. Processed Vg1 protein is an axial mesoderm inducer in Xenopus. Cell. 1993 Aug 13; 74(3):433-41. PMID: 8348610.
    Citations: 54     Fields:    Translation:AnimalsCells
  121. Dohrmann CE, Hemmati-Brivanlou A, Thomsen GH, Fields A, Woolf TM, Melton DA. Expression of activin mRNA during early development in Xenopus laevis. Dev Biol. 1993 Jun; 157(2):474-83. PMID: 8500654.
    Citations: 12     Fields:    Translation:AnimalsCells
  122. Sokol SY, Melton DA. Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus. Dev Biol. 1992 Dec; 154(2):348-55. PMID: 1426642.
    Citations: 8     Fields:    Translation:Animals
  123. Hemmati-Brivanlou A, Melton DA. A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature. 1992 Oct 15; 359(6396):609-14. PMID: 1328888.
    Citations: 62     Fields:    Translation:AnimalsCells
  124. Woolf TM, Melton DA, Jennings CG. Specificity of antisense oligonucleotides in vivo. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7305-9. PMID: 1380154.
    Citations: 48     Fields:    Translation:AnimalsCells
  125. Hemmati-Brivanlou A, Wright DA, Melton DA. Embryonic expression and functional analysis of a Xenopus activin receptor. Dev Dyn. 1992 May; 194(1):1-11. PMID: 1384808.
    Citations: 8     Fields:    Translation:AnimalsCells
  126. Mowry KL, Melton DA. Vegetal messenger RNA localization directed by a 340-nt RNA sequence element in Xenopus oocytes. Science. 1992 Feb 21; 255(5047):991-4. PMID: 1546297.
    Citations: 70     Fields:    Translation:AnimalsCells
  127. Jessell TM, Melton DA. Diffusible factors in vertebrate embryonic induction. Cell. 1992 Jan 24; 68(2):257-70. PMID: 1310256.
    Citations: 39     Fields:    Translation:AnimalsCells
  128. Sokol S, Christian JL, Moon RT, Melton DA. Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell. 1991 Nov 15; 67(4):741-52. PMID: 1834344.
    Citations: 87     Fields:    Translation:Animals
  129. Sokol S, Melton DA. Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin. Nature. 1991 May 30; 351(6325):409-11. PMID: 2034291.
    Citations: 17     Fields:    Translation:Animals
  130. Melton DA. Pattern formation during animal development. Science. 1991 Apr 12; 252(5003):234-41. PMID: 1672778.
    Citations: 22     Fields:    Translation:AnimalsCells
  131. O'Keefe HP, Melton DA, Ferreiro B, Kintner C. In situ hyridization. Methods Cell Biol. 1991; 36:443-63. PMID: 1811146.
    Citations: 3     Fields:    Translation:AnimalsCells
  132. Vize PD, Melton DA, Hemmati-Brivanlou A, Harland RM. Assays for gene function in developing Xenopus embryos. Methods Cell Biol. 1991; 36:367-87. PMID: 1811145.
    Citations: 25     Fields:    Translation:Animals
  133. Thomsen G, Woolf T, Whitman M, Sokol S, Vaughan J, Vale W, Melton DA. Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell. 1990 Nov 02; 63(3):485-93. PMID: 2225062.
    Citations: 65     Fields:    Translation:AnimalsCells
  134. Sokol S, Wong GG, Melton DA. A mouse macrophage factor induces head structures and organizes a body axis in Xenopus. Science. 1990 Aug 03; 249(4968):561-4. PMID: 2382134.
    Citations: 8     Fields:    Translation:AnimalsCells
  135. Woolf TM, Jennings CG, Rebagliati M, Melton DA. The stability, toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides in Xenopus oocytes and embryos. Nucleic Acids Res. 1990 Apr 11; 18(7):1763-9. PMID: 1692405.
    Citations: 41     Fields:    Translation:AnimalsCells
  136. Ruiz i Altaba A, Melton DA. Axial patterning and the establishment of polarity in the frog embryo. Trends Genet. 1990 Feb; 6(2):57-64. PMID: 2186530.
    Citations: 2     Fields:    Translation:Animals
  137. Yisraeli JK, Sokol S, Melton DA. A two-step model for the localization of maternal mRNA in Xenopus oocytes: involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA. Development. 1990 Feb; 108(2):289-98. PMID: 2351071.
    Citations: 79     Fields:    Translation:AnimalsCells
  138. Whitman M, Melton DA. Signal transduction during mesoderm induction in Xenopus. J Reprod Fertil Suppl. 1990; 42:249-54. PMID: 2077128.
    Citations:    Fields:    Translation:AnimalsCells
  139. Ruiz i Altaba A, Melton DA. Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos. Nature. 1989 Sep 07; 341(6237):33-8. PMID: 2570357.
    Citations: 25     Fields:    Translation:Animals
  140. Tannahill D, Melton DA. Localized synthesis of the Vg1 protein during early Xenopus development. Development. 1989 Aug; 106(4):775-85. PMID: 2562668.
    Citations: 15     Fields:    Translation:AnimalsCells
  141. Whitman M, Melton DA. Induction of mesoderm by a viral oncogene in early Xenopus embryos. Science. 1989 May 19; 244(4906):803-6. PMID: 2658054.
    Citations: 3     Fields:    Translation:AnimalsCells
  142. Ruiz i Altaba A, Melton DA. Bimodal and graded expression of the Xenopus homeobox gene Xhox3 during embryonic development. Development. 1989 May; 106(1):173-83. PMID: 2576399.
    Citations: 15     Fields:    Translation:AnimalsCells
  143. Krieg PA, Varnum SM, Wormington WM, Melton DA. The mRNA encoding elongation factor 1-alpha (EF-1 alpha) is a major transcript at the midblastula transition in Xenopus. Dev Biol. 1989 May; 133(1):93-100. PMID: 2707491.
    Citations: 55     Fields:    Translation:AnimalsCells
  144. Ruiz i Altaba A, Melton DA. Involvement of the Xenopus homeobox gene Xhox3 in pattern formation along the anterior-posterior axis. Cell. 1989 Apr 21; 57(2):317-26. PMID: 2564813.
    Citations: 20     Fields:    Translation:Animals
  145. Melton DA, Ruiz i Altaba A, Yisraeli J, Sokol S. Localization of mRNA and axis formation during Xenopus embryogenesis. Ciba Found Symp. 1989; 144:16-29; discussion 29-36, 92-8. PMID: 2673675.
    Citations: 3     Fields:    Translation:Animals
  146. Yisraeli JK, Sokol S, Melton DA. The process of localizing a maternal messenger RNA in Xenopus oocytes. Development. 1989; 107 Suppl:31-6. PMID: 2636138.
    Citations: 2     Fields:    Translation:AnimalsCells
  147. Whitman M, Melton DA. Growth factors in early embryogenesis. Annu Rev Cell Biol. 1989; 5:93-117. PMID: 2688710.
    Citations: 17     Fields:    Translation:HumansAnimals
  148. Yisraeli JK, Melton DA. The material mRNA Vg1 is correctly localized following injection into Xenopus oocytes. Nature. 1988 Dec 08; 336(6199):592-5. PMID: 3200307.
    Citations: 27     Fields:    Translation:AnimalsCells
  149. Harvey RP, Melton DA. Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos. Cell. 1988 Jun 03; 53(5):687-97. PMID: 2897242.
    Citations: 25     Fields:    Translation:AnimalsCells
  150. Weeks DL, Melton DA. A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta. Cell. 1987 Dec 04; 51(5):861-7. PMID: 3479264.
    Citations: 100     Fields:    Translation:AnimalsCells
  151. Ruiz i Altaba A, Perry-O'Keefe H, Melton DA. Xfin: an embryonic gene encoding a multifingered protein in Xenopus. EMBO J. 1987 Oct; 6(10):3065-70. PMID: 2826129.
    Citations: 42     Fields:    Translation:AnimalsCells
  152. Kintner CR, Melton DA. Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction. Development. 1987 Mar; 99(3):311-25. PMID: 2443340.
    Citations: 54     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.