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profileDouglas A. Melton, Ph.D.

TitleXander University Professor of Stem Cell and Regenerative Biology
InstitutionFaculty of Arts & Sciences
DepartmentStem Cell and Regenerative Biology
AddressHarvard, FAS Molecular & Cell Biology
Fairchild 467
7 Divinity Ave
Cambridge MA 02138
Phone617/495-9488
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
UC4DK104218     (GREINER, DALE LESLIE)Sep 25, 2014 - Jun 30, 2019
NIH/NIDDK
Humanized Mouse Avatars for T1D
Role: Co-Principal Investigator

UC4DK104159     (MELTON, DOUGLAS A)Sep 23, 2014 - Aug 31, 2017
NIH/NIDDK
Biomarkers for Diabetes Using Stem Cell-Derived Beta Cells
Role: Principal Investigator

UC4DK104165     (MELTON, DOUGLAS A)Sep 20, 2014 - Jun 30, 2019
NIH/NIDDK
Islet on a Chip
Role: Principal Investigator

R24DK092758     (MELTON, DOUGLAS A)Sep 1, 2011 - Aug 31, 2013
NIH/NIDDK
Reconstruction of Human Type 1 Diabetes in Mice
Role: Principal Investigator

RC4DK090781     (MELTON, DOUGLAS A)Sep 25, 2010 - Sep 30, 2013
NIH/NIDDK
Identification of Genes and Compounds That Control Beta Cell Replication
Role: Principal Investigator
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This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Melton Lab - iPS cells (21)
Harvard Stem Cell Institute - Research opportunities (1)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA. Corrigendum: Generation of stem cell-derived ß-cells from patients with type 1 diabetes. Nat Commun. 2016 Aug 04; 7:12379. PMID: 27487970; PMCID: PMC4976199.
  2. Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA. Generation of stem cell-derived ß-cells from patients with type 1 diabetes. Nat Commun. 2016 May 10; 7:11463. PMID: 27163171; PMCID: PMC4866045.
  3. Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q. Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 03; 18(3):410-21. PMID: 26908146; PMCID: PMC4779391 [Available on 03/03/17].
  4. Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG. Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med. 2016 Mar; 22(3):306-11. PMID: 26808346; PMCID: PMC4825868.
  5. Melton DA. Applied Developmental Biology: Making Human Pancreatic Beta Cells for Diabetics. Curr Top Dev Biol. 2016; 117:65-73. PMID: 26969972.
    View in: PubMed
  6. Ben-Zvi D, Barrandon O, Hadley S, Blum B, Peterson QP, Melton DA. Angptl4 links a-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15498-503. PMID: 26621734; PMCID: PMC4687559.
  7. Chetty S, Engquist EN, Mehanna E, Lui KO, Tsankov AM, Melton DA. A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation. J Cell Biol. 2015 Sep 28; 210(7):1257-68. PMID: 26416968; PMCID: PMC4586752.
  8. Kenty JH, Melton DA. Testing pancreatic islet function at the single cell level by calcium influx with associated marker expression. PLoS One. 2015; 10(4):e0122044. PMID: 25853429; PMCID: PMC4390334.
  9. Ben-Zvi D, Melton DA. Modeling human nutrition using human embryonic stem cells. Cell. 2015 Mar 26; 161(1):12-7. PMID: 25815980.
    View in: PubMed
  10. Pagliuca FW, Millman JR, Gürtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D, Melton DA. Generation of functional human pancreatic ß cells in vitro. Cell. 2014 Oct 09; 159(2):428-39. PMID: 25303535; PMCID: PMC4617632.
  11. Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DA. Reversal of ß cell de-differentiation by a small molecule inhibitor of the TGFß pathway. Elife. 2014 Sep 16; 3:e02809. PMID: 25233132; PMCID: PMC4204634.
  12. Hrvatin S, Deng F, O'Donnell CW, Gifford DK, Melton DA. MARIS: method for analyzing RNA following intracellular sorting. PLoS One. 2014; 9(3):e89459. PMID: 24594682; PMCID: PMC3940959.
  13. Hrvatin S, O'Donnell CW, Deng F, Millman JR, Pagliuca FW, DiIorio P, Rezania A, Gifford DK, Melton DA. Differentiated human stem cells resemble fetal, not adult, ß cells. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3038-43. PMID: 24516164; PMCID: PMC3939927.
  14. Li W, Nakanishi M, Zumsteg A, Shear M, Wright C, Melton DA, Zhou Q. In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. Elife. 2014 Jan 01; 3:e01846. PMID: 24714494; PMCID: PMC3977343.
  15. Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA. Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells. 2013 Dec; 31(12):2833-41. PMID: 23765749; PMCID: PMC4617635.
  16. Pagliuca FW, Melton DA. How to make a functional ß-cell. Development. 2013 Jun; 140(12):2472-83. PMID: 23715541; PMCID: PMC3666377.
  17. Yi P, Park JS, Melton DA. Betatrophin: a hormone that controls pancreatic ß cell proliferation. Cell. 2013 May 09; 153(4):747-58. PMID: 23623304; PMCID: PMC3756510.
  18. Chetty S, Pagliuca FW, Honore C, Kweudjeu A, Rezania A, Melton DA. A simple tool to improve pluripotent stem cell differentiation. Nat Methods. 2013 Jun; 10(6):553-6. PMID: 23584186; PMCID: PMC3694177.
  19. Chen AE, Borowiak M, Sherwood RI, Kweudjeu A, Melton DA. Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation. Development. 2013 Feb 01; 140(3):675-86. PMID: 23293299; PMCID: PMC3561793.
  20. Carolan PJ, Melton DA. New findings in pancreatic and intestinal endocrine development to advance regenerative medicine. Curr Opin Endocrinol Diabetes Obes. 2013 Feb; 20(1):1-7. PMID: 23249759.
    View in: PubMed
  21. Sneddon JB, Borowiak M, Melton DA. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature. 2012 Nov 29; 491(7426):765-8. PMID: 23041930.
    View in: PubMed
  22. Blum B, Hrvatin SS, Schuetz C, Bonal C, Rezania A, Melton DA. Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. Nat Biotechnol. 2012 Feb 26; 30(3):261-4. PMID: 22371083; PMCID: PMC4617627.
  23. Annes JP, Ryu JH, Lam K, Carolan PJ, Utz K, Hollister-Lock J, Arvanites AC, Rubin LL, Weir G, Melton DA. Adenosine kinase inhibition selectively promotes rodent and porcine islet ß-cell replication. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3915-20. PMID: 22345561; PMCID: PMC3309788.
  24. Egli D, Chen AE, Saphier G, Ichida J, Fitzgerald C, Go KJ, Acevedo N, Patel J, Baetscher M, Kearns WG, Goland R, Leibel RL, Melton DA, Eggan K. Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun. 2011 Oct 04; 2:488. PMID: 21971503; PMCID: PMC3335196.
  25. Melton DA. Using stem cells to study and possibly treat type 1 diabetes. Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12; 366(1575):2307-11. PMID: 21727136; PMCID: PMC3130419.
  26. Sherwood RI, Maehr R, Mazzoni EO, Melton DA. Wnt signaling specifies and patterns intestinal endoderm. Mech Dev. 2011 Sep-Dec; 128(7-10):387-400. PMID: 21854845; PMCID: PMC3223331.
  27. Cohen DE, Melton D. Turning straw into gold: directing cell fate for regenerative medicine. Nat Rev Genet. 2011 Apr; 12(4):243-52. PMID: 21386864.
    View in: PubMed
  28. Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 2010 Feb 01; 24(3):312-26. PMID: 20123909; PMCID: PMC2811832.
  29. Borowiak M, Melton DA. How to make beta cells? Curr Opin Cell Biol. 2009 Dec; 21(6):727-32. PMID: 19781928; PMCID: PMC4617625.
  30. Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA. Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15768-73. PMID: 19720998.
    View in: PubMed
  31. Guseh JS, Bores SA, Stanger BZ, Zhou Q, Anderson WJ, Melton DA, Rajagopal J. Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development. 2009 May; 136(10):1751-9. PMID: 19369400; PMCID: PMC2673763.
  32. Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell. 2009 Apr 03; 4(4):348-58. PMID: 19341624; PMCID: PMC4564293.
  33. Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr; 5(4):258-65. PMID: 19287398.
    View in: PubMed
  34. Brennand K, Melton D. Slow and steady is the key to beta-cell replication. J Cell Mol Med. 2009 Mar; 13(3):472-87. PMID: 19379145; PMCID: PMC2820566.
  35. Chen AE, Egli D, Niakan K, Deng J, Akutsu H, Yamaki M, Cowan C, Fitz-Gerald C, Zhang K, Melton DA, Eggan K. Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell. 2009 Feb 06; 4(2):103-6. PMID: 19200798; PMCID: PMC3335201.
  36. Sherwood RI, Chen TY, Melton DA. Transcriptional dynamics of endodermal organ formation. Dev Dyn. 2009 Jan; 238(1):29-42. PMID: 19097184; PMCID: PMC3756511.
  37. Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, Muhlestein W, Melton DA. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol. 2008 Nov; 26(11):1269-75. PMID: 18849973.
    View in: PubMed
  38. Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, Melton DA. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol. 2008 Jul; 26(7):795-7. PMID: 18568017.
    View in: PubMed
  39. Rajagopal J, Carroll TJ, Guseh JS, Bores SA, Blank LJ, Anderson WJ, Yu J, Zhou Q, McMahon AP, Melton DA. Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development. 2008 May; 135(9):1625-34. PMID: 18367557; PMCID: PMC2556060.
  40. Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien KR, Melton DA. Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol. 2008 Mar; 26(3):313-5. PMID: 18278034.
    View in: PubMed
  41. Anderson WJ, Zhou Q, Alcalde V, Kaneko OF, Blank LJ, Sherwood RI, Guseh JS, Rajagopal J, Melton DA. Genetic targeting of the endoderm with claudin-6CreER. Dev Dyn. 2008 Feb; 237(2):504-12. PMID: 18213590; PMCID: PMC2665265.
  42. Zhou Q, Melton DA. Pathways to new beta cells. Cold Spring Harb Symp Quant Biol. 2008; 73:175-81. PMID: 19478324.
    View in: PubMed
  43. Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA. A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell. 2007 Jul; 13(1):103-14. PMID: 17609113.
    View in: PubMed
  44. Brennand K, Huangfu D, Melton D. All beta cells contribute equally to islet growth and maintenance. PLoS Biol. 2007 Jul; 5(7):e163. PMID: 17535113.
    View in: PubMed
  45. Stanger BZ, Tanaka AJ, Melton DA. Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature. 2007 Feb 22; 445(7130):886-91. PMID: 17259975.
    View in: PubMed
  46. Sherwood RI, Jitianu C, Cleaver O, Shaywitz DA, Lamenzo JO, Chen AE, Golub TR, Melton DA. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Dev Biol. 2007 Apr 15; 304(2):541-55. PMID: 17328885.
    View in: PubMed
  47. Greenwood AL, Li S, Jones K, Melton DA. Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate. Mech Dev. 2007 Feb; 124(2):97-107. PMID: 17196797.
    View in: PubMed
  48. Melton DA. Reversal of type 1 diabetes in mice. N Engl J Med. 2006 Jul 06; 355(1):89-90. PMID: 16823003.
    View in: PubMed
  49. Nikolova G, Jabs N, Konstantinova I, Domogatskaya A, Tryggvason K, Sorokin L, Fässler R, Gu G, Gerber HP, Ferrara N, Melton DA, Lammert E. The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell. 2006 Mar; 10(3):397-405. PMID: 16516842.
    View in: PubMed
  50. Akutsu H, Cowan CA, Melton D. Human embryonic stem cells. Methods Enzymol. 2006; 418:78-92. PMID: 17141030.
    View in: PubMed
  51. Murtaugh LC, Law AC, Dor Y, Melton DA. Beta-catenin is essential for pancreatic acinar but not islet development. Development. 2005 Nov; 132(21):4663-74. PMID: 16192304.
    View in: PubMed
  52. Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005 Sep; 8(3):185-95. PMID: 16169464.
    View in: PubMed
  53. Cowan CA, Atienza J, Melton DA, Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science. 2005 Aug 26; 309(5739):1369-73. PMID: 16123299.
    View in: PubMed
  54. Stanger BZ, Datar R, Murtaugh LC, Melton DA. Direct regulation of intestinal fate by Notch. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12443-8. PMID: 16107537; PMCID: PMC1194941.
  55. Melton DA, Daley GQ, Jennings CG. Altered nuclear transfer in stem-cell research - a flawed proposal. N Engl J Med. 2004 Dec 30; 351(27):2791-2. PMID: 15625329.
    View in: PubMed
  56. Dor Y, Melton DA. How important are adult stem cells for tissue maintenance? Cell Cycle. 2004 Sep; 3(9):1104-6. PMID: 15326371.
    View in: PubMed
  57. Annerén C, Cowan CA, Melton DA. The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. J Biol Chem. 2004 Jul 23; 279(30):31590-8. PMID: 15148312.
    View in: PubMed
  58. Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004 May 06; 429(6987):41-6. PMID: 15129273.
    View in: PubMed
  59. Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, Zucker JP, Wang S, Morton CC, McMahon AP, Powers D, Melton DA. Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med. 2004 Mar 25; 350(13):1353-6. PMID: 14999088.
    View in: PubMed
  60. Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA. Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development. 2004 Jan; 131(1):165-79. PMID: 14660441.
    View in: PubMed
  61. Murtaugh LC, Stanger BZ, Kwan KM, Melton DA. Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):14920-5. PMID: 14657333; PMCID: PMC299853.
  62. Kumar M, Melton D. Pancreas specification: a budding question. Curr Opin Genet Dev. 2003 Aug; 13(4):401-7. PMID: 12888014.
    View in: PubMed
  63. Kumar M, Jordan N, Melton D, Grapin-Botton A. Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev Biol. 2003 Jul 01; 259(1):109-22. PMID: 12812792.
    View in: PubMed
  64. Cleaver O, Melton DA. Endothelial signaling during development. Nat Med. 2003 Jun; 9(6):661-8. PMID: 12778164.
    View in: PubMed
  65. Chiang MK, Melton DA. Single-cell transcript analysis of pancreas development. Dev Cell. 2003 Mar; 4(3):383-93. PMID: 12636919.
    View in: PubMed
  66. Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA. Insulin staining of ES cell progeny from insulin uptake. Science. 2003 Jan 17; 299(5605):363. PMID: 12532008.
    View in: PubMed
  67. Lammert E, Cleaver O, Melton D. Role of endothelial cells in early pancreas and liver development. Mech Dev. 2003 Jan; 120(1):59-64. PMID: 12490296.
    View in: PubMed
  68. Murtaugh LC, Melton DA. Genes, signals, and lineages in pancreas development. Annu Rev Cell Dev Biol. 2003; 19:71-89. PMID: 14570564.
    View in: PubMed
  69. Gu G, Brown JR, Melton DA. Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev. 2003 Jan; 120(1):35-43. PMID: 12490294.
    View in: PubMed
  70. Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA. "Stemness": transcriptional profiling of embryonic and adult stem cells. Science. 2002 Oct 18; 298(5593):597-600. PMID: 12228720.
    View in: PubMed
  71. Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 2002 May; 129(10):2447-57. PMID: 11973276.
    View in: PubMed
  72. Fishman MP, Melton DA. Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells. Int J Dev Biol. 2002 Mar; 46(2):201-7. PMID: 11934148.
    View in: PubMed
  73. Lammert E, Cleaver O, Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science. 2001 Oct 19; 294(5542):564-7. PMID: 11577200.
    View in: PubMed
  74. Grapin-Botton A, Majithia AR, Melton DA. Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev. 2001 Feb 15; 15(4):444-54. PMID: 11230152; PMCID: PMC312631.
  75. Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA. Regulation of pancreas development by hedgehog signaling. Development. 2000 Nov; 127(22):4905-13. PMID: 11044404.
    View in: PubMed
  76. Schuldiner M, Yanuka O, Itskovitz-Eldor J, Melton DA, Benvenisty N. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21):11307-12. PMID: 11027332; PMCID: PMC17196.
  77. Kelly OG, Melton DA. Development of the pancreas in Xenopus laevis. Dev Dyn. 2000 Aug; 218(4):615-27. PMID: 10906780.
    View in: PubMed
  78. Lammert E, Brown J, Melton DA. Notch gene expression during pancreatic organogenesis. Mech Dev. 2000 Jun; 94(1-2):199-203. PMID: 10842072.
    View in: PubMed
  79. Ramalho-Santos M, Melton DA, McMahon AP. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development. 2000 Jun; 127(12):2763-72. PMID: 10821773.
    View in: PubMed
  80. Wells JM, Melton DA. Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development. 2000 Apr; 127(8):1563-72. PMID: 10725233.
    View in: PubMed
  81. Grapin-Botton A, Melton DA. Endoderm development: from patterning to organogenesis. Trends Genet. 2000 Mar; 16(3):124-30. PMID: 10689353.
    View in: PubMed
  82. Hebrok M, Kim SK, Melton DA. Screening for novel pancreatic genes expressed during embryogenesis. Diabetes. 1999 Aug; 48(8):1550-6. PMID: 10426372.
    View in: PubMed
  83. Wells JM, Melton DA. Vertebrate endoderm development. Annu Rev Cell Dev Biol. 1999; 15:393-410. PMID: 10611967.
    View in: PubMed
  84. Kim SK, Melton DA. Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13036-41. PMID: 9789036; PMCID: PMC23700.
  85. Henry GL, Melton DA. Mixer, a homeobox gene required for endoderm development. Science. 1998 Jul 03; 281(5373):91-6. PMID: 9651252.
    View in: PubMed
  86. Joseph EM, Melton DA. Mutant Vg1 ligands disrupt endoderm and mesoderm formation in Xenopus embryos. Development. 1998 Jul; 125(14):2677-85. PMID: 9636082.
    View in: PubMed
  87. Hebrok M, Kim SK, Melton DA. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 1998 Jun 01; 12(11):1705-13. PMID: 9620856; PMCID: PMC316875.
  88. Kim SK, Hebrok M, Melton DA. Notochord to endoderm signaling is required for pancreas development. Development. 1997 Nov; 124(21):4243-52. PMID: 9334273.
    View in: PubMed
  89. Joseph EM, Melton DA. Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer. Dev Biol. 1997 Apr 15; 184(2):367-72. PMID: 9133442.
    View in: PubMed
  90. Melton D. Signals for tissue induction and organ formation in vertebrate embryos. Harvey Lect. 1997-1998; 93:49-64. PMID: 10941418.
    View in: PubMed
  91. Kim SK, Hebrok M, Melton DA. Pancreas development in the chick embryo. Cold Spring Harb Symp Quant Biol. 1997; 62:377-83. PMID: 9598372.
    View in: PubMed
  92. Reilly KM, Melton DA. Short-range signaling by candidate morphogens of the TGF beta family and evidence for a relay mechanism of induction. Cell. 1996 Sep 06; 86(5):743-54. PMID: 8797821.
    View in: PubMed
  93. Klein PS, Melton DA. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8455-9. PMID: 8710892; PMCID: PMC38692.
  94. Newfeld SJ, Chartoff EH, Graff JM, Melton DA, Gelbart WM. Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells. Development. 1996 Jul; 122(7):2099-108. PMID: 8681791.
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  95. Graff JM, Bansal A, Melton DA. Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily. Cell. 1996 May 17; 85(4):479-87. PMID: 8653784.
    View in: PubMed
  96. Dohrmann CE, Kessler DS, Melton DA. Induction of axial mesoderm by zDVR-1, the zebrafish orthologue of Xenopus Vg1. Dev Biol. 1996 Apr 10; 175(1):108-17. PMID: 8608857.
    View in: PubMed
  97. Henry GL, Brivanlou IH, Kessler DS, Hemmati-Brivanlou A, Melton DA. TGF-beta signals and a pattern in Xenopus laevis endodermal development. Development. 1996 Mar; 122(3):1007-15. PMID: 8631246.
    View in: PubMed
  98. Kelly OG, Melton DA. Induction and patterning of the vertebrate nervous system. Trends Genet. 1995 Jul; 11(7):273-8. PMID: 7482777.
    View in: PubMed
  99. Kessler DS, Melton DA. Induction of dorsal mesoderm by soluble, mature Vg1 protein. Development. 1995 Jul; 121(7):2155-64. PMID: 7635059.
    View in: PubMed
  100. Klein PS, Melton DA. Translational control of activin in Xenopus laevis embryos. Dev Genet. 1995; 17(1):55-64. PMID: 7554495.
    View in: PubMed
  101. Kessler DS, Melton DA. Vertebrate embryonic induction: mesodermal and neural patterning. Science. 1994 Oct 28; 266(5185):596-604. PMID: 7939714.
    View in: PubMed
  102. Graff JM, Thies RS, Song JJ, Celeste AJ, Melton DA. Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell. 1994 Oct 07; 79(1):169-79. PMID: 7522972.
    View in: PubMed
  103. Klein PS, Melton DA. Induction of mesoderm in Xenopus laevis embryos by translation initiation factor 4E. Science. 1994 Aug 05; 265(5173):803-6. PMID: 8047887.
    View in: PubMed
  104. Wilson PA, Melton DA. Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr Biol. 1994 Aug 01; 4(8):676-86. PMID: 7953553.
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  105. Klein PS, Melton DA. Hormonal regulation of embryogenesis: the formation of mesoderm in Xenopus laevis. Endocr Rev. 1994 Jun; 15(3):326-41. PMID: 8076585.
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  106. Hemmati-Brivanlou A, Melton DA. Inhibition of activin receptor signaling promotes neuralization in Xenopus. Cell. 1994 Apr 22; 77(2):273-81. PMID: 8168134.
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  107. Hemmati-Brivanlou A, Kelly OG, Melton DA. Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell. 1994 Apr 22; 77(2):283-95. PMID: 8168135.
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  108. Ku M, Melton DA. Xwnt-11: a maternally expressed Xenopus wnt gene. Development. 1993 Dec; 119(4):1161-73. PMID: 8306880.
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  109. Thomsen GH, Melton DA. Processed Vg1 protein is an axial mesoderm inducer in Xenopus. Cell. 1993 Aug 13; 74(3):433-41. PMID: 8348610.
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  110. Dohrmann CE, Hemmati-Brivanlou A, Thomsen GH, Fields A, Woolf TM, Melton DA. Expression of activin mRNA during early development in Xenopus laevis. Dev Biol. 1993 Jun; 157(2):474-83. PMID: 8500654.
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  111. Sokol SY, Melton DA. Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus. Dev Biol. 1992 Dec; 154(2):348-55. PMID: 1426642.
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  112. Hemmati-Brivanlou A, Melton DA. A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature. 1992 Oct 15; 359(6396):609-14. PMID: 1328888.
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  113. Woolf TM, Melton DA, Jennings CG. Specificity of antisense oligonucleotides in vivo. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7305-9. PMID: 1380154; PMCID: PMC49698.
  114. Hemmati-Brivanlou A, Wright DA, Melton DA. Embryonic expression and functional analysis of a Xenopus activin receptor. Dev Dyn. 1992 May; 194(1):1-11. PMID: 1384808.
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  115. Mowry KL, Melton DA. Vegetal messenger RNA localization directed by a 340-nt RNA sequence element in Xenopus oocytes. Science. 1992 Feb 21; 255(5047):991-4. PMID: 1546297.
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  116. Jessell TM, Melton DA. Diffusible factors in vertebrate embryonic induction. Cell. 1992 Jan 24; 68(2):257-70. PMID: 1310256.
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  117. Sokol S, Christian JL, Moon RT, Melton DA. Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell. 1991 Nov 15; 67(4):741-52. PMID: 1834344.
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  118. Sokol S, Melton DA. Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin. Nature. 1991 May 30; 351(6325):409-11. PMID: 2034291.
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  119. Melton DA. Pattern formation during animal development. Science. 1991 Apr 12; 252(5003):234-41. PMID: 1672778.
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  120. O'Keefe HP, Melton DA, Ferreiro B, Kintner C. In situ hyridization. Methods Cell Biol. 1991; 36:443-63. PMID: 1811146.
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  121. Vize PD, Melton DA, Hemmati-Brivanlou A, Harland RM. Assays for gene function in developing Xenopus embryos. Methods Cell Biol. 1991; 36:367-87. PMID: 1811145.
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  122. Thomsen G, Woolf T, Whitman M, Sokol S, Vaughan J, Vale W, Melton DA. Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell. 1990 Nov 02; 63(3):485-93. PMID: 2225062.
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  123. Sokol S, Wong GG, Melton DA. A mouse macrophage factor induces head structures and organizes a body axis in Xenopus. Science. 1990 Aug 03; 249(4968):561-4. PMID: 2382134.
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  124. Woolf TM, Jennings CG, Rebagliati M, Melton DA. The stability, toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides in Xenopus oocytes and embryos. Nucleic Acids Res. 1990 Apr 11; 18(7):1763-9. PMID: 1692405; PMCID: PMC330594.
  125. Ruiz i Altaba A, Melton DA. Axial patterning and the establishment of polarity in the frog embryo. Trends Genet. 1990 Feb; 6(2):57-64. PMID: 2186530.
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  126. Yisraeli JK, Sokol S, Melton DA. A two-step model for the localization of maternal mRNA in Xenopus oocytes: involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA. Development. 1990 Feb; 108(2):289-98. PMID: 2351071.
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  127. Whitman M, Melton DA. Signal transduction during mesoderm induction in Xenopus. J Reprod Fertil Suppl. 1990; 42:249-54. PMID: 2077128.
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  128. Ruiz i Altaba A, Melton DA. Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos. Nature. 1989 Sep 07; 341(6237):33-8. PMID: 2570357.
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  129. Tannahill D, Melton DA. Localized synthesis of the Vg1 protein during early Xenopus development. Development. 1989 Aug; 106(4):775-85. PMID: 2562668.
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  130. Whitman M, Melton DA. Induction of mesoderm by a viral oncogene in early Xenopus embryos. Science. 1989 May 19; 244(4906):803-6. PMID: 2658054.
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  131. Ruiz i Altaba A, Melton DA. Bimodal and graded expression of the Xenopus homeobox gene Xhox3 during embryonic development. Development. 1989 May; 106(1):173-83. PMID: 2576399.
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  132. Krieg PA, Varnum SM, Wormington WM, Melton DA. The mRNA encoding elongation factor 1-alpha (EF-1 alpha) is a major transcript at the midblastula transition in Xenopus. Dev Biol. 1989 May; 133(1):93-100. PMID: 2707491.
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  133. Ruiz i Altaba A, Melton DA. Involvement of the Xenopus homeobox gene Xhox3 in pattern formation along the anterior-posterior axis. Cell. 1989 Apr 21; 57(2):317-26. PMID: 2564813.
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  134. Melton DA, Ruiz i Altaba A, Yisraeli J, Sokol S. Localization of mRNA and axis formation during Xenopus embryogenesis. Ciba Found Symp. 1989; 144:16-29; discussion 29-36, 92-8. PMID: 2673675.
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  135. Yisraeli JK, Sokol S, Melton DA. The process of localizing a maternal messenger RNA in Xenopus oocytes. Development. 1989; 107 Suppl:31-6. PMID: 2636138.
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  136. Whitman M, Melton DA. Growth factors in early embryogenesis. Annu Rev Cell Biol. 1989; 5:93-117. PMID: 2688710.
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  137. Yisraeli JK, Melton DA. The material mRNA Vg1 is correctly localized following injection into Xenopus oocytes. Nature. 1988 Dec 08; 336(6199):592-5. PMID: 3200307.
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  138. Harvey RP, Melton DA. Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos. Cell. 1988 Jun 03; 53(5):687-97. PMID: 2897242.
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  139. Weeks DL, Melton DA. A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta. Cell. 1987 Dec 04; 51(5):861-7. PMID: 3479264.
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  140. Ruiz i Altaba A, Perry-O'Keefe H, Melton DA. Xfin: an embryonic gene encoding a multifingered protein in Xenopus. EMBO J. 1987 Oct; 6(10):3065-70. PMID: 2826129; PMCID: PMC553744.
  141. Kintner CR, Melton DA. Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction. Development. 1987 Mar; 99(3):311-25. PMID: 2443340.
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