David Lagares, Ph.D.
|Title||Instructor in Medicine|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
149 13th Street
Charlestown MA 02129
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David Lagares, PhD
Director of the Matrix and Mechanobiology Program, Fibrosis Research Center,
Massachusetts General Hospital - Harvard Medical School
Lagares Laboratory: Tissue Repair, Regeneration and Fibrosis
The ability of organs to regenerate following injury declines with age. In older aged individuals, chronic tissue injury leads to abnormal wound healing responses characterized by the development of scar tissue or fibrosis and subsequent organ failure. The identification of novel therapeutic strategies aiming at reducing tissue fibrosis and promoting the regeneration of damaged tissues is a major unmet clinical need in regenerative medicine.
The goal of the Lagares Laboratory is to understand the cellular and molecular mechanisms that regulate the delicate balance between organ regeneration and fibrosis following tissue injury, with an emphasis on the biochemical and biomechanical drivers of scar-forming myofibroblast activation. Ultimately, we seek to develop novel anti-fibrotic therapies for the treatment of human diseases such as idiopathic pulmonary fibrosis, systemic sclerosis, liver cirrhosis, progressive kidney disease and desmoplastic tumors.
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