Harvard Catalyst Profiles

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Mohlopheni Marakalala, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Pillaye JN, Marakalala MJ, Khumalo N, Spearman W, Ndlovu H. Mechanistic insights into antiretroviral drug-induced liver injury. Pharmacol Res Perspect. 2020 08; 8(4):e00598. PMID: 32643320.
    Citations: 2     Fields:    Translation:HumansAnimals
  2. Hadebe S, Chengalroyen M, Guler R, Nakedi K, Koch A, Makatsa M, Shey M, Parihar SP, Bryson B, Marakalala MJ, Ndlovu H. Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town. Gates Open Res. 2019; 3:1491. PMID: 32478309.
  3. Ardain A, Marakalala MJ, Leslie A. Tissue-resident innate immunity in the lung. Immunology. 2020 03; 159(3):245-256. PMID: 31670391.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  4. Marakalala MJ, Martinez FO, Plüddemann A, Gordon S. Macrophage Heterogeneity in the Immunopathogenesis of Tuberculosis. Front Microbiol. 2018; 9:1028. PMID: 29875747.
    Citations: 17     
  5. Wagener M, Hoving JC, Ndlovu H, Marakalala MJ. Dectin-1-Syk-CARD9 Signaling Pathway in TB Immunity. Front Immunol. 2018; 9:225. PMID: 29487599.
    Citations: 14     Fields:    Translation:HumansCells
  6. Parihar SP, Ozturk M, Marakalala MJ, Loots DT, Hurdayal R, Beukes D, Van Reenen M, Zak DE, Mbandi SK, Darboe F, Penn-Nicholson A, Hanekom WA, Leitges M, Scriba TJ, Guler R, Brombacher F. Protein kinase C-delta (PKCd), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice. Mucosal Immunol. 2018 03; 11(2):579-580. PMID: 29346346.
    Citations: 4     Fields:    
  7. Kurthkoti K, Amin H, Marakalala MJ, Ghanny S, Subbian S, Sakatos A, Livny J, Fortune SM, Berney M, Rodriguez GM. The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Granulomas. mBio. 2017 08 15; 8(4). PMID: 28811344.
    Citations: 31     Fields:    Translation:HumansCells
  8. Parihar SP, Ozturk M, Marakalala MJ, Loots DT, Hurdayal R, Maasdorp DB, Van Reenen M, Zak DE, Darboe F, Penn-Nicholson A, Hanekom WA, Leitges M, Scriba TJ, Guler R, Brombacher F. Protein kinase C-delta (PKCd), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice. Mucosal Immunol. 2018 03; 11(2):496-511. PMID: 28832027.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  9. Marakalala MJ, Ndlovu H. Signaling C-type lectin receptors in antimycobacterial immunity. PLoS Pathog. 2017 06; 13(6):e1006333. PMID: 28640912.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  10. Ndlovu H, Marakalala MJ. Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis. Front Immunol. 2016; 7:434. PMID: 27822210.
    Citations: 28     Fields:    
  11. Marakalala MJ, Raju RM, Sharma K, Zhang YJ, Eugenin EA, Prideaux B, Daudelin IB, Chen PY, Booty MG, Kim JH, Eum SY, Via LE, Behar SM, Barry CE, Mann M, Dartois V, Rubin EJ. Inflammatory signaling in human tuberculosis granulomas is spatially organized. Nat Med. 2016 05; 22(5):531-8. PMID: 27043495.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  12. Wilson GJ, Marakalala MJ, Hoving JC, van Laarhoven A, Drummond RA, Kerscher B, Keeton R, van de Vosse E, Ottenhoff TH, Plantinga TS, Alisjahbana B, Govender D, Besra GS, Netea MG, Reid DM, Willment JA, Jacobs M, Yamasaki S, van Crevel R, Brown GD. The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. Cell Host Microbe. 2015 Feb 11; 17(2):252-9. PMID: 25674984.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  13. Mavrici D, Marakalala MJ, Holton JM, Prigozhin DM, Gee CL, Zhang YJ, Rubin EJ, Alber T. Mycobacterium tuberculosis FtsX extracellular domain activates the peptidoglycan hydrolase, RipC. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8037-42. PMID: 24843173.
    Citations: 33     Fields:    Translation:Cells
  14. Marakalala MJ. In vitro Analysis for Macrophage Binding and Pro-inflammatory Responses to Candida albicans. Bio Protoc. 2014 May 05; 4(9). PMID: 29226178.
  15. Marakalala MJ, Vautier S, Potrykus J, Walker LA, Shepardson KM, Hopke A, Mora-Montes HM, Kerrigan A, Netea MG, Murray GI, Maccallum DM, Wheeler R, Munro CA, Gow NA, Cramer RA, Brown AJ, Brown GD. Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1. PLoS Pathog. 2013; 9(4):e1003315. PMID: 23637604.
    Citations: 95     Fields:    Translation:AnimalsCells
  16. Marakalala MJ, Williams DL, Hoving JC, Engstad R, Netea MG, Brown GD. Dectin-1 plays a redundant role in the immunomodulatory activities of ß-glucan-rich ligands in vivo. Microbes Infect. 2013 Jun; 15(6-7):511-5. PMID: 23518266.
    Citations: 22     Fields:    Translation:AnimalsCells
  17. Broadley SG, Gumbart JC, Weber BW, Marakalala MJ, Steenkamp DJ, Sewell BT. A new crystal form of MshB from Mycobacterium tuberculosis with glycerol and acetate in the active site suggests the catalytic mechanism. Acta Crystallogr D Biol Crystallogr. 2012 Nov; 68(Pt 11):1450-9. PMID: 23090394.
    Citations: 3     Fields:    Translation:Cells
  18. Strasser D, Neumann K, Bergmann H, Marakalala MJ, Guler R, Rojowska A, Hopfner KP, Brombacher F, Urlaub H, Baier G, Brown GD, Leitges M, Ruland J. Syk kinase-coupled C-type lectin receptors engage protein kinase C-d to elicit Card9 adaptor-mediated innate immunity. Immunity. 2012 01 27; 36(1):32-42. PMID: 22265677.
    Citations: 100     Fields:    Translation:AnimalsCells
  19. Marakalala MJ, Graham LM, Brown GD. The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections. Clin Dev Immunol. 2010; 2010:567571. PMID: 21274433.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  20. Marakalala MJ, Guler R, Matika L, Murray G, Jacobs M, Brombacher F, Rothfuchs AG, Sher A, Brown GD. The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice. Microbes Infect. 2011 Feb; 13(2):198-201. PMID: 21034845.
    Citations: 22     Fields:    Translation:AnimalsCells
  21. Marakalala MJ, Kerrigan AM, Brown GD. Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans. Mamm Genome. 2011 Feb; 22(1-2):55-65. PMID: 20700596.
    Citations: 20     Fields:    Translation:HumansAnimals
  22. Green VA, Munshi SU, Marakalala MJ, Mourão MM. Molecular mechanisms of viral infection and propagation: an overview of the second Advanced Summer School in Africa. IUBMB Life. 2010 Aug; 62(8):573-83. PMID: 20681023.
    Citations:    Fields:    Translation:HumansAnimals
  23. Gammon DW, Steenkamp DJ, Mavumengwana V, Marakalala MJ, Mudzunga TT, Hunter R, Munyololo M. Conjugates of plumbagin and phenyl-2-amino-1-thioglucoside inhibit MshB, a deacetylase involved in the biosynthesis of mycothiol. Bioorg Med Chem. 2010 Apr 01; 18(7):2501-14. PMID: 20304659.
    Citations: 5     Fields:    Translation:Cells
  24. Tsoni SV, Kerrigan AM, Marakalala MJ, Srinivasan N, Duffield M, Taylor PR, Botto M, Steele C, Brown GD. Complement C3 plays an essential role in the control of opportunistic fungal infections. Infect Immun. 2009 Sep; 77(9):3679-85. PMID: 19581397.
    Citations: 28     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.