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profileJanet Lo, M.D.

TitleAssistant Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Program in Nutritional Metabolism, LON207
55 Fruit St
Boston MA 02114
Phone617/724-2425
Fax617/724-8998
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01HL123351     (LO, JANET)May 7, 2014 - Apr 30, 2019
NIH/NHLBI
Targeting GI Epithelial Integrity to Improve Arterial Inflammation in HIV
Role: Principal Investigator

K23HL092792     (LO, JANET)Sep 2, 2008 - Oct 31, 2013
NIH/NHLBI
Atherosclerosis and Inflammation in HIV Disease
Role: Principal Investigator

F32HL088991     (LO, JANET)Jul 1, 2007 - Sep 24, 2007
NIH/NHLBI
Subclinical Coronary Atherosclerosis in HIV-Infected Patients
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hall LN, Sanchez LR, Hubbard J, Lee H, Looby SE, Srinivasa S, Zanni MV, Stanley TL, Lo J, Grinspoon SK, Fitch KV. Aspartame Intake Relates to Coronary Plaque Burden and Inflammatory Indices in Human Immunodeficiency Virus. Open Forum Infect Dis. 2017; 4(2):ofx083. PMID: 28695142.
    View in: PubMed
  2. Fitch KV, DeFilippi C, Christenson R, Srinivasa S, Lee H, Lo J, Lu MT, Wong K, Petrow E, Sanchez L, Looby SE, Hoffmann U, Zanni M, Grinspoon SK. Subclinical myocyte injury, fibrosis and strain in relationship to coronary plaque in asymptomatic HIV-infected individuals. AIDS. 2016 Sep 10; 30(14):2205-14. PMID: 27314177; PMCID: PMC5007151 [Available on 09/10/17].
  3. Nou E, Lo J, Grinspoon SK. Inflammation, immune activation, and cardiovascular disease in HIV. AIDS. 2016 Jun 19; 30(10):1495-509. PMID: 27058351; PMCID: PMC4889507 [Available on 06/19/17].
  4. Lo J, Lu MT, Kim EA, Nou E, Hallett TR, Park J, Hoffmann U, Grinspoon SK. Statin Effects to Reduce Hepatosteatosis as Measured by Computed Tomography in Patients With Human Immunodeficiency Virus. Open Forum Infect Dis. 2016 Apr; 3(2):ofw062. PMID: 27419149; PMCID: PMC4943550.
  5. Figueroa AL, Takx RA, MacNabb MH, Abdelbaky A, Lavender ZR, Kaplan RS, Truong QA, Lo J, Ghoshhajra BB, Grinspoon SK, Hoffmann U, Tawakol A. Relationship Between Measures of Adiposity, Arterial Inflammation, and Subsequent Cardiovascular Events. Circ Cardiovasc Imaging. 2016 Apr; 9(4):e004043. PMID: 27072302; PMCID: PMC5036397 [Available on 04/01/17].
  6. Nou E, Lu MT, Looby SE, Fitch KV, Kim EA, Lee H, Hoffmann U, Grinspoon SK, Lo J. Serum oxidized low-density lipoprotein decreases in response to statin therapy and relates independently to reductions in coronary plaque in patients with HIV. AIDS. 2016 Feb 20; 30(4):583-90. PMID: 26558731.
    View in: PubMed
  7. Nou E, Lo J, Hadigan C, Grinspoon SK. Pathophysiology and management of cardiovascular disease in patients with HIV. Lancet Diabetes Endocrinol. 2016 Jul; 4(7):598-610. PMID: 26873066; PMCID: PMC4921313 [Available on 07/01/17].
  8. Looby SE, Fitch KV, Srinivasa S, Lo J, Rafferty D, Martin A, Currier JC, Grinspoon S, Zanni MV. Reduced ovarian reserve relates to monocyte activation and subclinical coronary atherosclerotic plaque in women with HIV. AIDS. 2016 Jan 28; 30(3):383-93. PMID: 26696388; PMCID: PMC4713275 [Available on 01/28/17].
  9. Srinivasa S, Fitch KV, Wong K, Torriani M, Mayhew C, Stanley T, Lo J, Adler GK, Grinspoon SK. RAAS Activation Is Associated With Visceral Adiposity and Insulin Resistance Among HIV-infected Patients. J Clin Endocrinol Metab. 2015 Aug; 100(8):2873-82. PMID: 26086328; PMCID: PMC4525005 [Available on 08/01/16].
  10. Walford GA, Colomo N, Todd JN, Billings LK, Fernandez M, Chamarthi B, Warner AS, Davis J, Littleton KR, Hernandez AM, Fanelli RR, Lanier A, Barbato C, Ackerman RJ, Khan SQ, Bui R, Garber L, Stolerman ES, Moore AF, Huang C, Kaur V, Harden M, Taylor A, Chen L, Manning AK, Huang P, Wexler D, McCarthy RM, Lo J, Thomas MK, Grant RW, Goldfine A, Hudson MS, Florez JC. The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for type 2 diabetes. PLoS One. 2015; 10(3):e0121553. PMID: 25812009; PMCID: PMC4374872.
  11. Srinivasa S, Fitch KV, Lo J, Kadar H, Knight R, Wong K, Abbara S, Gauguier D, Capeau J, Boccara F, Grinspoon SK. Plaque burden in HIV-infected patients is associated with serum intestinal microbiota-generated trimethylamine. AIDS. 2015 Feb 20; 29(4):443-52. PMID: 25565500; PMCID: PMC4410017 [Available on 02/20/16].
  12. Li JZ, Arnold KB, Lo J, Dugast AS, Plants J, Ribaudo HJ, Cesa K, Heisey A, Kuritzkes DR, Lauffenburger DA, Alter G, Landay A, Grinspoon S, Pereyra F. Differential levels of soluble inflammatory markers by human immunodeficiency virus controller status and demographics. Open Forum Infect Dis. 2015 Jan; 2(1):ofu117. PMID: 25884005; PMCID: PMC4396431.
  13. Lo J, Lu MT, Ihenachor EJ, Wei J, Looby SE, Fitch KV, Oh J, Zimmerman CO, Hwang J, Abbara S, Plutzky J, Robbins G, Tawakol A, Hoffmann U, Grinspoon SK. Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial. Lancet HIV. 2015 Feb; 2(2):e52-63. PMID: 26424461; PMCID: PMC4820828.
  14. Lo J, Rosenberg ES, Fitzgerald ML, Bazner SB, Ihenachor EJ, Hawxhurst V, Borkowska AH, Wei J, Zimmerman CO, Burdo TH, Williams KC, Freeman MW, Grinspoon SK. High-density lipoprotein-mediated cholesterol efflux capacity is improved by treatment with antiretroviral therapy in acute human immunodeficiency virus infection. Open Forum Infect Dis. 2014 Dec; 1(3):ofu108. PMID: 25734176; PMCID: PMC4324225.
  15. Srinivasa S, Fitch KV, Petrow E, Burdo TH, Williams KC, Lo J, C?té HCF, Grinspoon SK. Soluble CD163 is associated with shortened telomere length in HIV-infected patients. J Acquir Immune Defic Syndr. 2014 Dec 01; 67(4):414-418. PMID: 25197827; PMCID: PMC4213298.
  16. Zanni MV, Fitch KV, Feldpausch M, Han A, Lee H, Lu MT, Abbara S, Ribaudo H, Douglas PS, Hoffmann U, Lo J, Grinspoon SK. 2013 American College of Cardiology/American Heart Association and 2004 Adult Treatment Panel III cholesterol guidelines applied to HIV-infected patients with/without subclinical high-risk coronary plaque. AIDS. 2014 Sep 10; 28(14):2061-70. PMID: 25265074; PMCID: PMC4405159.
  17. Tawakol A, Lo J, Zanni MV, Marmarelis E, Ihenachor EJ, MacNabb M, Wai B, Hoffmann U, Abbara S, Grinspoon S. Increased arterial inflammation relates to high-risk coronary plaque morphology in HIV-infected patients. J Acquir Immune Defic Syndr. 2014 Jun 01; 66(2):164-71. PMID: 24828267; PMCID: PMC4023912.
  18. Zanni MV, Kelesidis T, Fitzgerald ML, Lo J, Abbara S, Wai B, Marmarelis E, Hernandez NJ, Yang OO, Currier JS, Grinspoon SK. HDL redox activity is increased in HIV-infected men in association with macrophage activation and non-calcified coronary atherosclerotic plaque. Antivir Ther. 2014; 19(8):805-811. PMID: 24535655; PMCID: PMC4423391.
  19. Fitch KV, Srinivasa S, Abbara S, Burdo TH, Williams KC, Eneh P, Lo J, Grinspoon SK. Noncalcified coronary atherosclerotic plaque and immune activation in HIV-infected women. J Infect Dis. 2013 Dec 01; 208(11):1737-46. PMID: 24041790; PMCID: PMC3814845.
  20. Walford GA, Davis J, Warner AS, Ackerman RJ, Billings LK, Chamarthi B, Fanelli RR, Hernandez AM, Huang C, Khan SQ, Littleton KR, Lo J, McCarthy RM, Rhee EP, Deik A, Stolerman E, Taylor A, Hudson MS, Wang TJ, Altshuler D, Grant RW, Clish CB, Gerszten RE, Florez JC. Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus. Metabolism. 2013 Dec; 62(12):1772-8. PMID: 23953891; PMCID: PMC3833885.
  21. Zanni MV, Abbara S, Lo J, Wai B, Hark D, Marmarelis E, Grinspoon SK. Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men. AIDS. 2013 May 15; 27(8):1263-72. PMID: 23324657; PMCID: PMC3740057.
  22. Nolte JE, Neumann T, Manne JM, Lo J, Neumann A, Mostardt S, Abbara S, Hoffmann U, Brady TJ, Wasem J, Grinspoon SK, Gazelle GS, Goehler A. Cost-effectiveness analysis of coronary artery disease screening in HIV-infected men. Eur J Prev Cardiol. 2014 Aug; 21(8):972-9. PMID: 23539717; PMCID: PMC3841232.
  23. Pereyra F, Lo J, Triant VA, Wei J, Buzon MJ, Fitch KV, Hwang J, Campbell JH, Burdo TH, Williams KC, Abbara S, Grinspoon SK. Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers. AIDS. 2012 Nov 28; 26(18):2409-12. PMID: 23032411; PMCID: PMC3660105.
  24. Hwang JJ, Wei J, Abbara S, Grinspoon SK, Lo J. Receptor activator of nuclear factor-?B ligand (RANKL) and its relationship to coronary atherosclerosis in HIV patients. J Acquir Immune Defic Syndr. 2012 Nov 01; 61(3):359-63. PMID: 22842843; PMCID: PMC3766949.
  25. Subramanian S, Tawakol A, Burdo TH, Abbara S, Wei J, Vijayakumar J, Corsini E, Abdelbaky A, Zanni MV, Hoffmann U, Williams KC, Lo J, Grinspoon SK. Arterial inflammation in patients with HIV. JAMA. 2012 Jul 25; 308(4):379-86. PMID: 22820791; PMCID: PMC3724172.
  26. Lo J, Plutzky J. The biology of atherosclerosis: general paradigms and distinct pathogenic mechanisms among HIV-infected patients. J Infect Dis. 2012 Jun; 205 Suppl 3:S368-74. PMID: 22577210; PMCID: PMC3349296.
  27. Burdo TH, Lo J, Abbara S, Wei J, DeLelys ME, Preffer F, Rosenberg ES, Williams KC, Grinspoon S. Soluble CD163, a novel marker of activated macrophages, is elevated and associated with noncalcified coronary plaque in HIV-infected patients. J Infect Dis. 2011 Oct 15; 204(8):1227-36. PMID: 21917896; PMCID: PMC3203384.
  28. Lo J. Dyslipidemia and lipid management in HIV-infected patients. Curr Opin Endocrinol Diabetes Obes. 2011 Apr; 18(2):144-7. PMID: 21297466; PMCID: PMC3154840.
  29. Fitch KV, Lo J, Abbara S, Ghoshhajra B, Shturman L, Soni A, Sacks R, Wei J, Grinspoon S. Increased coronary artery calcium score and noncalcified plaque among HIV-infected men: relationship to metabolic syndrome and cardiac risk parameters. J Acquir Immune Defic Syndr. 2010 Dec; 55(4):495-9. PMID: 20720497; PMCID: PMC2974783.
  30. Lo J, Abbara S, Rocha-Filho JA, Shturman L, Wei J, Grinspoon SK. Increased epicardial adipose tissue volume in HIV-infected men and relationships to body composition and metabolic parameters. AIDS. 2010 Aug 24; 24(13):2127-30. PMID: 20588167; PMCID: PMC3620604.
  31. Lo J, You SM, Liebau J, Lee H, Grinspoon S. Effects of low-dose growth hormone withdrawal in patients with HIV. JAMA. 2010 Jul 21; 304(3):272-4. PMID: 20639560; PMCID: PMC3204609.
  32. Lo J, Grinspoon SK. Adrenal function in HIV infection. Curr Opin Endocrinol Diabetes Obes. 2010 Jun; 17(3):205-9. PMID: 20404726.
    View in: PubMed
  33. Lo J, Abbara S, Shturman L, Soni A, Wei J, Rocha-Filho JA, Nasir K, Grinspoon SK. Increased prevalence of subclinical coronary atherosclerosis detected by coronary computed tomography angiography in HIV-infected men. AIDS. 2010 Jan 16; 24(2):243-53. PMID: 19996940; PMCID: PMC3154841.
  34. Lo J, Looby SE, Wei J, Adler GK, Grinspoon SK. Increased aldosterone among HIV-infected women with visceral fat accumulation. AIDS. 2009 Nov 13; 23(17):2366-70. PMID: 19770620; PMCID: PMC2921849.
  35. Fitch KV, Guggina LM, Keough HM, Dolan Looby SE, Hadigan C, Anderson EJ, Hubbard J, Liebau JG, Johnsen S, Wei J, Makimura H, Stanley TL, Lo J, Grinspoon SK. Decreased respiratory quotient in relation to resting energy expenditure in HIV-infected and noninfected subjects. Metabolism. 2009 May; 58(5):608-15. PMID: 19375582; PMCID: PMC2691476.
  36. Lo J, You SM, Wei J, Canavan B, Grinspoon S. Relationship of peak growth hormone to cardiovascular parameters, waist circumference, lipids and glucose in HIV-infected patients and healthy adults. Clin Endocrinol (Oxf). 2009 Dec; 71(6):815-22. PMID: 19508594.
    View in: PubMed
  37. Nachtigall LB, Valassi E, Lo J, McCarty D, Passeri J, Biller BM, Miller KK, Utz A, Grinspoon S, Lawson EA, Klibanski A. Gender effects on cardiac valvular function in hyperprolactinaemic patients receiving cabergoline: a retrospective study. Clin Endocrinol (Oxf). 2010 Jan; 72(1):53-8. PMID: 19508591.
    View in: PubMed
  38. Lo J. Does growth hormone therapy benefit body composition and glucose homeostasis in girls with Turner syndrome? Nat Clin Pract Endocrinol Metab. 2008 Nov; 4(11):596-7. PMID: 18725904.
    View in: PubMed
  39. Lo J, You SM, Canavan B, Liebau J, Beltrani G, Koutkia P, Hemphill L, Lee H, Grinspoon S. Low-dose physiological growth hormone in patients with HIV and abdominal fat accumulation: a randomized controlled trial. JAMA. 2008 Aug 06; 300(5):509-19. PMID: 18677023; PMCID: PMC2532757.
  40. Stein JH, Hadigan CM, Brown TT, Chadwick E, Feinberg J, Friis-Møller N, Ganesan A, Glesby MJ, Hardy D, Kaplan RC, Kim P, Lo J, Martinez E, Sosman JM. Prevention strategies for cardiovascular disease in HIV-infected patients. Circulation. 2008 Jul 08; 118(2):e54-60. PMID: 18566315.
    View in: PubMed
  41. Lo J, Grinspoon S. Cardiovascular disease in HIV-infected patients: does HIV infection in and of itself increase cardiovascular risk? Curr Opin HIV AIDS. 2008 May; 3(3):207-13. PMID: 19372968.
    View in: PubMed
  42. Joy T, Keogh HM, Hadigan C, Dolan SE, Fitch K, Liebau J, Johnsen S, Lo J, Grinspoon SK. Relation of body composition to body mass index in HIV-infected patients with metabolic abnormalities. J Acquir Immune Defic Syndr. 2008 Feb 01; 47(2):174-84. PMID: 17971710; PMCID: PMC4393650.
  43. Joy T, Keogh HM, Hadigan C, Lee H, Dolan SE, Fitch K, Liebau J, Lo J, Johnsen S, Hubbard J, Anderson EJ, Grinspoon S. Dietary fat intake and relationship to serum lipid levels in HIV-infected patients with metabolic abnormalities in the HAART era. AIDS. 2007 Jul 31; 21(12):1591-600. PMID: 17630554; PMCID: PMC4393713.
  44. Lo J, Bernstein LE, Canavan B, Torriani M, Jackson MB, Ahima RS, Grinspoon SK. Effects of TNF-alpha neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E102-9. PMID: 17374698; PMCID: PMC3196534.
  45. Lo J, Dolan SE, Kanter JR, Hemphill LC, Connelly JM, Lees RS, Grinspoon SK. Effects of obesity, body composition, and adiponectin on carotid intima-media thickness in healthy women. J Clin Endocrinol Metab. 2006 May; 91(5):1677-82. PMID: 16522690; PMCID: PMC3210448.
  46. Janet Lo, MD, Sara E. Dolan, MSN, ANP, Jenna R. Kanter BA, Linda C. Hemphill, MD, Jean M. Connelly, MS, Robert S. Lees MD and Steven K. Grinspoon, MD . Effects of obesity, body composition, and adiponectin on carotid intima-media thickness in healthy women. Endocrine Society 88th Annual Meeting. 2006.
  47. Korner J, Lo J, Freda PU, Wardlaw SL. Treatment with cabergoline is associated with weight loss in patients with hyperprolactinemia. Obes Res. 2003 Feb; 11(2):311-2. PMID: 12582229.
    View in: PubMed
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