Harvard Catalyst Profiles

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Eric M Gale, Ph.D.

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Research
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  1. R21EB022804 (GALE, ERIC MICHAEL) Aug 1, 2016 - May 31, 2018
    NIH/NIBIB
    A Manganese Alternative to Gadolinium for MRI
    Role: Principal Investigator
  2. K25HL128899 (GALE, ERIC MICHAEL) May 1, 2016 - Apr 30, 2021
    NIH/NHLBI
    Characterizing the Cardiac Microenvironment with MRI
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wang H, Jordan VC, Ramsay IA, Sojoodi M, Fuchs BC, Tanabe KK, Caravan P, Gale EM. Molecular Magnetic Resonance Imaging Using a Redox-Active Iron Complex. J Am Chem Soc. 2019 Apr 10; 141(14):5916-5925. PMID: 30874437.
    Citations:    
  2. Wahsner J, Gale EM, Rodríguez-Rodríguez A, Caravan P. Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers. Chem Rev. 2019 Jan 23; 119(2):957-1057. PMID: 30350585.
    Citations:    Fields:    
  3. Wang J, Wang H, Ramsay IA, Erstad DJ, Fuchs BC, Tanabe KK, Caravan P, Gale EM. Manganese-Based Contrast Agents for Magnetic Resonance Imaging of Liver Tumors: Structure-Activity Relationships and Lead Candidate Evaluation. J Med Chem. 2018 Oct 11; 61(19):8811-8824. PMID: 30204438.
    Citations:    Fields:    
  4. Dai L, Jones CM, Chan WTK, Pham TA, Ling X, Gale EM, Rotile NJ, Tai WC, Anderson CJ, Caravan P, Law GL. Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications. Nat Commun. 2018 02 27; 9(1):857. PMID: 29487362.
    Citations:    
  5. Gale EM, Caravan P. Gadolinium-Free Contrast Agents for Magnetic Resonance Imaging of the Central Nervous System. ACS Chem Neurosci. 2018 03 21; 9(3):395-397. PMID: 29431424.
    Citations:    Fields:    
  6. Farrar CT, Gale EM, Kennan R, Ramsay I, Masia R, Arora G, Looby K, Wei L, Kalpathy-Cramer J, Bunzel MM, Zhang C, Zhu Y, Akiyama TE, Klimas M, Pinto S, Diyabalanage H, Tanabe KK, Humblet V, Fuchs BC, Caravan P. CM-101: Type I Collagen-targeted MR Imaging Probe for Detection of Liver Fibrosis. Radiology. 2018 05; 287(2):581-589. PMID: 29156148.
    Citations: 2     Fields:    Translation:Animals
  7. Gale EM, Wey HY, Ramsay I, Yen YF, Sosnovik DE, Caravan P. A Manganese-based Alternative to Gadolinium: Contrast-enhanced MR Angiography, Excretion, Pharmacokinetics, and Metabolism. Radiology. 2018 03; 286(3):865-872. PMID: 29117483.
    Citations: 1     Fields:    Translation:Animals
  8. Truong PT, Gale EM, Dzul SP, Stemmler TL, Harrop TC. Steric Enforcement about One Thiolate Donor Leads to New Oxidation Chemistry in a NiSOD Model Complex. Inorg Chem. 2017 Jul 17; 56(14):7761-7780. PMID: 28459242.
    Citations: 1     Fields:    
  9. Gale EM, Caravan P, Rao AG, McDonald RJ, Winfeld M, Fleck RJ, Gee MS. Gadolinium-based contrast agents in pediatric magnetic resonance imaging. Pediatr Radiol. 2017 May; 47(5):507-521. PMID: 28409250.
    Citations: 2     Fields:    Translation:Humans
  10. Gale EM, Jones CM, Ramsay I, Farrar CT, Caravan P. A Janus Chelator Enables Biochemically Responsive MRI Contrast with Exceptional Dynamic Range. J Am Chem Soc. 2016 12 14; 138(49):15861-15864. PMID: 27960350.
    Citations: 1     Fields:    Translation:HumansCells
  11. Gale EM, Atanasova IP, Blasi F, Ay I, Caravan P. A Manganese Alternative to Gadolinium for MRI Contrast. J Am Chem Soc. 2015 Dec 16; 137(49):15548-57. PMID: 26588204.
    Citations: 11     Fields:    Translation:Cells
  12. Broering EP, Dillon S, Gale EM, Steiner RA, Telser J, Brunold TC, Harrop TC. Accessing Ni(III)-thiolate versus Ni(II)-thiyl bonding in a family of Ni-N2S2 synthetic models of NiSOD. Inorg Chem. 2015 Apr 20; 54(8):3815-28. PMID: 25835183.
    Citations: 2     Fields:    Translation:Cells
  13. Boros E, Gale EM, Caravan P. MR imaging probes: design and applications. Dalton Trans. 2015 Mar 21; 44(11):4804-4818. PMID: 25376893.
    Citations: 13     Fields:    Translation:HumansAnimals
  14. Gale EM, Mukherjee S, Liu C, Loving GS, Caravan P. Structure-redox-relaxivity relationships for redox responsive manganese-based magnetic resonance imaging probes. Inorg Chem. 2014 Oct 06; 53(19):10748-61. PMID: 25226090.
    Citations: 2     Fields:    Translation:Cells
  15. Zhu J, Gale EM, Atanasova I, Rietz TA, Caravan P. Hexameric Mn(II) dendrimer as MRI contrast agent. Chemistry. 2014 Oct 27; 20(44):14507-13. PMID: 25224391.
    Citations: 3     Fields:    Translation:Animals
  16. Gale EM, Zhu J, Caravan P. Direct measurement of the Mn(II) hydration state in metal complexes and metalloproteins through 17O NMR line widths. J Am Chem Soc. 2013 Dec 11; 135(49):18600-8. PMID: 24088013.
    Citations: 5     Fields:    
  17. Gale EM, Kenton N, Caravan P. [Gd(CyPic3A)(H2O)2]-: a stable, bis(aquated) and high-relaxivity Gd(III) complex. Chem Commun (Camb). 2013 Sep 21; 49(73):8060-2. PMID: 23903523.
    Citations:    Fields:    
  18. Broering EP, Truong PT, Gale EM, Harrop TC. Synthetic analogues of nickel superoxide dismutase: a new role for nickel in biology. Biochemistry. 2013 Jan 08; 52(1):4-18. PMID: 23240653.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  19. Gale EM, Cowart DM, Scott RA, Harrop TC. Dipeptide-based models of nickel superoxide dismutase: solvent effects highlight a critical role to Ni-S bonding and active site stabilization. Inorg Chem. 2011 Oct 17; 50(20):10460-71. PMID: 21932766.
    Citations: 3     Fields:    Translation:Cells
  20. Gale EM, Simmonett AC, Telser J, Schaefer HF, Harrop TC. Toward functional Ni-SOD biomimetics: achieving a structural/electronic correlation with redox dynamics. Inorg Chem. 2011 Oct 03; 50(19):9216-8. PMID: 21888395.
    Citations: 3     Fields:    Translation:Cells
  21. Gale EM, Narendrapurapu BS, Simmonett AC, Schaefer HF, Harrop TC. Exploring the effects of H-bonding in synthetic analogues of nickel superoxide dismutase (Ni-SOD): experimental and theoretical implications for protection of the Ni-SCys bond. Inorg Chem. 2010 Aug 02; 49(15):7080-96. PMID: 20575514.
    Citations: 4     Fields:    Translation:Cells
  22. Gale EM, Patra AK, Harrop TC. Versatile methodology toward NiN(2)S(2) complexes as nickel superoxide dismutase models: structure and proton affinity. Inorg Chem. 2009 Jul 06; 48(13):5620-2. PMID: 20507097.
    Citations: 4     Fields:    Translation:Cells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.