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profileHao Wu, Ph.D.

TitleAsa and Patricia Springer Professor of Structural Biology, Professor of Biological Chemistry and Molecular Pharmacology
InstitutionBoston Children's Hospital
DepartmentBiological Chemistry & Molecular Pharmacology
AddressChildren's Hospital
Clsb-3098
3 Blackfan Circle
Boston MA 02115
Phone617/713-8160
vCardDownload vCard (login for email)
Other Positions
TitleAsa and Patricia Springer Professor of Structural Biology
InstitutionBoston Children's Hospital
DepartmentPediatrics
DivisionImmunology


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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ru H, Chambers MG, Fu TM, Tong AB, Liao M, Wu H. Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell. 2015 Nov 19; 163(5):1138-52. PMID: 26548953; PMCID: PMC4690471.
  2. Zhang L, Shuobing C, Jianbin R, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H. Cryo-EM structure of the activated NAIP2/NLRC4 Inflammasome reveals nucleated polymerization. Science. 2015; 350:404-9.
  3. Ferrao R, Zhou H, Shan Y, Liu Q, Li Q, Shaw DE, Li X, Wu H. IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assembly. Mol Cell. 2014 Sep 18; 55(6):891-903. PMID: 25201411; PMCID: PMC4169746.
  4. Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell. 2014 Mar 13; 156(6):1193-206. PMID: 24630722; PMCID: PMC4000066.
  5. Qiao Q, Yang C, Zheng C, Fontán L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman EH, Wu H. Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly. Mol Cell. 2013 Sep 26; 51(6):766-79. PMID: 24074955; PMCID: PMC3929958.
  6. Wu H. Higher-order assemblies in a new paradigm of signal transduction. Cell. 2013 Apr 11; 153(2):287-92. PMID: 23582320; PMCID: PMC3687143.
  7. Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E, Garcia M, Cerchietti L, Shaknovich R, Yang SN, Fang F, Gascoyne RD, Martinez-Climent JA, Glickman JF, Borden K, Wu H, Melnick A. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec 11; 22(6):812-24. PMID: 23238016; PMCID: PMC3984478.
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