Harvard Catalyst Profiles

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Sanda Alexandrescu, M.D.

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selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Blandin AF, Giglio R, Graham MS, Garcia G, Malinowski S, Woods JK, Ramkissoon S, Ramkissoon L, Dubois F, Schoolcraft K, Tsai J, Wang D, Jones R, Vogelzang J, Pelton K, Becker S, Watkinson F, Sinai C, Cohen EF, Booker MA, Tolstorukov MY, Haemels V, Goumnerova L, Wright K, Kieran M, Fehnel K, Reardon D, Tauziède-Espariat A, Lulla R, Carcamo B, Chaleff S, Charest A, De Smet F, Ligon AH, Dubuc A, Pages M, Varlet P, Wen PY, Alexander BM, Chi S, Alexandrescu S, Kittler R, Bachoo R, Bandopadhayay P, Beroukhim R, Ligon KL. ALK amplification and rearrangements are recurrent targetable events in congenital and adult glioblastoma. Clin Cancer Res. 2023 Feb 13. PMID: 36780194.
    Citations:    Fields:    
  2. Yeo KK, Alexandrescu S, Cotter JA, Vogelzang J, Bhave V, Li MM, Ji J, Benhamida JK, Rosenblum MK, Bale TA, Bouvier N, Kaneva K, Rosenberg T, Lim-Fat MJ, Ghosh H, Martinez M, Aguilera D, Smith A, Goldman S, Diamond EL, Gavrilovic I, MacDonald TJ, Wood MD, Nazemi KJ, Truong A, Cluster A, Ligon KL, Cole K, Bi WL, Margol AS, Karajannis MA, Wright KD. Multi-institutional study of the frequency, genomic landscape, and outcome of IDH-mutant glioma in pediatrics. Neuro Oncol. 2023 01 05; 25(1):199-210. PMID: 35604410; PMCID: PMC9825351.
    Citations:    Fields:    
  3. Liu I, Jiang L, Samuelsson ER, Marco Salas S, Beck A, Hack OA, Jeong D, Shaw ML, Englinger B, LaBelle J, Mire HM, Madlener S, Mayr L, Quezada MA, Trissal M, Panditharatna E, Ernst KJ, Vogelzang J, Gatesman TA, Halbert ME, Palova H, Pokorna P, Sterba J, Slaby O, Geyeregger R, Diaz A, Findlay IJ, Dun MD, Resnick A, Suvà ML, Jones DTW, Agnihotri S, Svedlund J, Koschmann C, Haberler C, Czech T, Slavc I, Cotter JA, Ligon KL, Alexandrescu S, Yung WKA, Arrillaga-Romany I, Gojo J, Monje M, Nilsson M, Filbin MG. The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location. Nat Genet. 2022 12; 54(12):1881-1894. PMID: 36471067; PMCID: PMC9729116.
    Citations:    Fields:    Translation:Humans
  4. Stredny CM, Blessing MM, Yi V, Ryan ME, Zhang B, Solomon IH, Prabhu SP, Alexandrescu S, Gorman MP. Mimics of Pediatric Small Vessel Primary Angiitis of the Central Nervous System. Ann Neurol. 2023 01; 93(1):109-119. PMID: 36254350.
    Citations:    Fields:    Translation:Humans
  5. Rosenberg T, Yeo KK, Mauguen A, Alexandrescu S, Prabhu SP, Tsai JW, Malinowski S, Joshirao M, Parikh K, Farouk Sait S, Rosenblum MK, Benhamida JK, Michaiel G, Tran HN, Dahiya S, Kachurak K, Friedman GK, Krystal JI, Huang MA, Margol AS, Wright KD, Aguilera D, MacDonald TJ, Chi SN, Karajannis MA. Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma. Neuro Oncol. 2022 11 02; 24(11):1964-1975. PMID: 35397478; PMCID: PMC9629451.
    Citations:    Fields:    
  6. Cimino PJ, Ketchum C, Turakulov R, Singh O, Abdullaev Z, Giannini C, Pytel P, Lopez GY, Colman H, Nasrallah MP, Santi M, Fernandes IL, Nirschl J, Dahiya S, Neill S, Solomon D, Perez E, Capper D, Mani H, Caccamo D, Ball M, Badruddoja M, Chkheidze R, Camelo-Piragua S, Fullmer J, Alexandrescu S, Yeaney G, Eberhart C, Martinez-Lage M, Chen J, Zach L, Kleinschmidt-DeMasters BK, Hefti M, Lopes MB, Nuechterlein N, Horbinski C, Rodriguez FJ, Quezado M, Pratt D, Aldape K. Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1. Acta Neuropathol. 2023 Jan; 145(1):71-82. PMID: 36271929; PMCID: PMC9844520.
    Citations:    Fields:    Translation:HumansCells
  7. Woods JK, Lidov HG, Ligon KL, Santagata S, Chi SN, Yeo KK, Alexandrescu S. PD-L1 and PD-1 expression in pediatric central nervous system germ cell tumors. Mod Pathol. 2022 12; 35(12):1770-1774. PMID: 36057740.
    Citations:    Fields:    Translation:Humans
  8. Pal S, Kaplan JP, Nguyen H, Stopka SA, Savani MR, Regan MS, Nguyen QD, Jones KL, Moreau LA, Peng J, Dipiazza MG, Perciaccante AJ, Zhu X, Hunsel BR, Liu KX, Alexandrescu S, Drissi R, Filbin MG, McBrayer SK, Agar NYR, Chowdhury D, Haas-Kogan DA. A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma. Cancer Cell. 2022 09 12; 40(9):957-972.e10. PMID: 35985342; PMCID: PMC9575661.
    Citations: 2     Fields:    Translation:HumansAnimals
  9. Harpaz N, Mittelman T, Beresh O, Griess O, Furth N, Salame TM, Oren R, Fellus-Alyagor L, Harmelin A, Alexandrescu S, Marques JG, Filbin MG, Ron G, Shema E. Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas. Mol Cell. 2022 07 21; 82(14):2696-2713.e9. PMID: 35716669.
    Citations:    Fields:    Translation:HumansCells
  10. Liu KX, Shang HH, Cacciotti C, Everdell E, Aizer AA, Rahman R, Malinowski S, Meredith DM, Kamihara J, Wen PY, Ligon KL, Chi SN, Marcus KJ, Yeo KK, Alexandrescu S, Haas-Kogan DA. DICER1 mutations in primary central nervous system tumors: new insights into histologies, mutations, and prognosis. J Neurooncol. 2022 May; 157(3):499-510. PMID: 35384518.
    Citations:    Fields:    Translation:Humans
  11. Meredith DM, Alexandrescu S. Embryonal and non-meningothelial mesenchymal tumors of the central nervous system - Advances in diagnosis and prognostication. Brain Pathol. 2022 07; 32(4):e13059. PMID: 35266242; PMCID: PMC9245947.
    Citations: 3     Fields:    Translation:Humans
  12. Kemps PG, Picarsic J, Durham BH, Hélias-Rodzewicz Z, Hiemcke-Jiwa L, van den Bos C, van de Wetering MD, van Noesel CJM, van Laar JAM, Verdijk RM, Flucke UE, Hogendoorn PCW, Woei-A-Jin FJSH, Sciot R, Beilken A, Feuerhake F, Ebinger M, Möhle R, Fend F, Bornemann A, Wiegering V, Ernestus K, Méry T, Gryniewicz-Kwiatkowska O, Dembowska-Baginska B, Evseev DA, Potapenko V, Baykov VV, Gaspari S, Rossi S, Gessi M, Tamburrini G, Héritier S, Donadieu J, Bonneau-Lagacherie J, Lamaison C, Farnault L, Fraitag S, Jullié ML, Haroche J, Collin M, Allotey J, Madni M, Turner K, Picton S, Barbaro PM, Poulin A, Tam IS, El Demellawy D, Empringham B, Whitlock JA, Raghunathan A, Swanson AA, Suchi M, Brandt JM, Yaseen NR, Weinstein JL, Eldem I, Sisk BA, Sridhar V, Atkinson M, Massoth LR, Hornick JL, Alexandrescu S, Yeo KK, Petrova-Drus K, Peeke SZ, Muñoz-Arcos LS, Leino DG, Grier DD, Lorsbach R, Roy S, Kumar AR, Garg S, Tiwari N, Schafernak KT, Henry MM, van Halteren AGS, Abla O, Diamond EL, Emile JF. ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition. Blood. 2022 01 13; 139(2):256-280. PMID: 34727172; PMCID: PMC8759533.
    Citations: 3     Fields:    Translation:Humans
  13. Koh HY, Haghighi A, Keywan C, Alexandrescu S, Plews-Ogan E, Haas EA, Brownstein CA, Vargas SO, Haynes RL, Berry GT, Holm IA, Poduri AH, Goldstein RD. Genetic Determinants of Sudden Unexpected Death in Pediatrics. Genet Med. 2022 04; 24(4):839-850. PMID: 35027292; PMCID: PMC9164313.
    Citations:    Fields:    Translation:Humans
  14. Haynes RL, Kinney HC, Haas EA, Duncan JR, Riehs M, Trachtenberg F, Armstrong DD, Alexandrescu S, Cryan JB, Hefti MM, Krous HF, Goldstein RD, Sleeper LA. Medullary Serotonergic Binding Deficits and Hippocampal Abnormalities in Sudden Infant Death Syndrome: One or Two Entities? Front Pediatr. 2021; 9:762017. PMID: 34993162; PMCID: PMC8724302.
    Citations:    
  15. Sloan EA, Gupta R, Koelsche C, Chiang J, Villanueva-Meyer JE, Alexandrescu S, Eschbacher JM, Wang W, Mafra M, Ud Din N, Carr-Boyd E, Watson M, Punsoni M, Oviedo A, Gilani A, Kleinschmidt-DeMasters BK, Coss DJ, Lopes MB, Reddy A, Mueller S, Cho SJ, Horvai AE, Lee JC, Pekmezci M, Tihan T, Bollen AW, Rodriguez FJ, Ellison DW, Perry A, von Deimling A, Chang SM, Berger MS, Solomon DA. Intracranial mesenchymal tumors with FET-CREB fusion are composed of at least two epigenetic subgroups distinct from meningioma and extracranial sarcomas. Brain Pathol. 2022 07; 32(4):e13037. PMID: 34821426; PMCID: PMC9245938.
    Citations: 1     Fields:    Translation:Humans
  16. Patel V, Alexandrescu S. Immunohistochemical surrogates for molecular alterations for the classification and grading of gliomas. Semin Diagn Pathol. 2022 Jan; 39(1):78-83. PMID: 34857434.
    Citations:    Fields:    Translation:Humans
  17. Huang L, Bichsel C, Norris AL, Thorpe J, Pevsner J, Alexandrescu S, Pinto A, Zurakowski D, Kleiman RJ, Sahin M, Greene AK, Bischoff J. Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels. Arterioscler Thromb Vasc Biol. 2022 01; 42(1):e27-e43. PMID: 34670408; PMCID: PMC8702487.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  18. Ahrendsen JT, Sinai C, Meredith DM, Malinowski SW, Cooney TM, Bandopadhayay P, Ligon KL, Alexandrescu S. Molecular Alterations in Pediatric Low-Grade Gliomas That Led to Death. J Neuropathol Exp Neurol. 2021 11 19; 80(11):1052–1059. PMID: 34580728.
    Citations:    Fields:    Translation:HumansCells
  19. Al-Ibraheemi A, Putra J, Tsai HK, Cano S, Lip V, Pinches RS, Restrepo T, Alexandrescu S, Janeway KA, Duraisamy S, Harris MH, Church AJ. Assessment of BCOR Internal Tandem Duplications in Pediatric Cancers by Targeted RNA Sequencing. J Mol Diagn. 2021 10; 23(10):1269-1278. PMID: 34325058.
    Citations:    Fields:    Translation:HumansCells
  20. Ahrendsen JT, Torre M, Meredith DM, Hornick JL, Reardon DA, Wen PY, Yeo KK, Malinowski S, Ligon KL, Ramkissoon S, Alexandrescu S. IDH-mutant gliomas with additional class-defining molecular events. Mod Pathol. 2021 07; 34(7):1236-1244. PMID: 33772213.
    Citations: 1     Fields:    Translation:Humans
  21. Tsai JW, Manoharan N, Alexandrescu S, Zimmerman MA, Scully J, Chordas C, Clymer J, Wright KD, Filbin M, Ullrich NJ, Marcus KJ, Haas-Kogan D, Chi SN, Bandopadhayay P, Yeo KK. Outcomes after first relapse of childhood intracranial ependymoma. Pediatr Blood Cancer. 2021 08; 68(8):e28930. PMID: 33565268.
    Citations: 4     Fields:    Translation:Humans
  22. Sesen J, Driscoll J, Shah N, Moses-Gardner A, Luiselli G, Alexandrescu S, Zurakowski D, Baxter PA, Su JM, Pricola Fehnel K, Smith ER. Neogenin is highly expressed in diffuse intrinsic pontine glioma and influences tumor invasion. Brain Res. 2021 07 01; 1762:147348. PMID: 33571520.
    Citations: 2     Fields:    Translation:HumansCells
  23. Sloan EA, Chiang J, Villanueva-Meyer JE, Alexandrescu S, Eschbacher JM, Wang W, Mafra M, Ud Din N, Carr-Boyd E, Watson M, Punsoni M, Oviedo A, Gilani A, Kleinschmidt-DeMasters BK, Coss DJ, Lopes MB, Raffel C, Berger MS, Chang SM, Reddy A, Ramani B, Ferris SP, Lee JC, Hofmann JW, Cho SJ, Horvai AE, Pekmezci M, Tihan T, Bollen AW, Rodriguez FJ, Ellison DW, Perry A, Solomon DA. Intracranial mesenchymal tumor with FET-CREB fusion-A unifying diagnosis for the spectrum of intracranial myxoid mesenchymal tumors and angiomatoid fibrous histiocytoma-like neoplasms. Brain Pathol. 2021 07; 31(4):e12918. PMID: 33141488; PMCID: PMC8089120.
    Citations: 13     Fields:    Translation:Humans
  24. Alexandrescu S, Meredith DM, Lidov HG, Alaggio R, Novello M, Ligon KL, Vargas SO. Loss of histone H3 trimethylation on lysine 27 and nuclear expression of transducin-like enhancer 1 in primary intracranial sarcoma, DICER1-mutant. Histopathology. 2021 Jan; 78(2):265-275. PMID: 32692439.
    Citations: 2     Fields:    Translation:HumansCells
  25. Giannikou K, Zhu Z, Kim J, Winden KD, Tyburczy ME, Marron D, Parker JS, Hebert Z, Bongaarts A, Taing L, Long HW, Pisano WV, Alexandrescu S, Godlewski B, Nellist M, Kotulska K, Jozwiak S, Roszkowski M, Mandera M, Thiele EA, Lidov H, Getz G, Devinsky O, Lawrence MS, Ligon KL, Ellison DW, Sahin M, Aronica E, Meredith DM, Kwiatkowski DJ. Subependymal giant cell astrocytomas are characterized by mTORC1 hyperactivation, a very low somatic mutation rate, and a unique gene expression profile. Mod Pathol. 2021 02; 34(2):264-279. PMID: 33051600; PMCID: PMC9361192.
    Citations: 2     Fields:    Translation:HumansCells
  26. Pinches RS, Clinton CM, Ward A, Meyer SC, Al-Ibraheemi A, Forrest SJ, Strand GR, Detert H, Piche-Schulman A, Gill K, Restrepo T, Tavares Proulx R, Perez-Atayde AR, Vargas SO, Shaikh R, Weldon C, Alexandrescu S, Hong AL, O'Neill AF, Hollowell M, Harris MH, Janeway KA, Crompton BD, Church AJ. Making the most of small samples: Optimization of tissue allocation of pediatric solid tumors for clinical and research use. Pediatr Blood Cancer. 2020 09; 67(9):e28326. PMID: 32667141.
    Citations:    Fields:    Translation:Humans
  27. Torre M, Vasudevaraja V, Serrano J, DeLorenzo M, Malinowski S, Blandin AF, Pages M, Ligon AH, Dong F, Meredith DM, Nasrallah MP, Horbinski C, Dahiya S, Ligon KL, Santi M, Ramkissoon SH, Filbin MG, Snuderl M, Alexandrescu S. Molecular and clinicopathologic features of gliomas harboring NTRK fusions. Acta Neuropathol Commun. 2020 07 14; 8(1):107. PMID: 32665022; PMCID: PMC7362646.
    Citations: 30     Fields:    Translation:Humans
  28. Matthew Torre, Varshini Vasudevaraja, Jonathan Serrano, Michael DeLorenzo, Seth Malinowski, Ann-Florence Blandin, Melanie Pages, Azra H. Ligon, Fei Dong, David M. Meredith, Maclean P. Nazrallah, Craig Horbinski, Sonika Dahiya, Keith L. Ligon, Mariarita Santi, Shakti H. Ramkissoon, Mariella G. Filbin, Matija Snuderl, Sanda Alexandrescu. Molecular and clinicopathologic features of gliomas harboring NTRK fusions. Acta Neuropathologica Communications. 2020; (8). View Publication.
  29. Gojo J, Englinger B, Jiang L, Hübner JM, Shaw ML, Hack OA, Madlener S, Kirchhofer D, Liu I, Pyrdol J, Hovestadt V, Mazzola E, Mathewson ND, Trissal M, Lötsch D, Dorfer C, Haberler C, Halfmann A, Mayr L, Peyrl A, Geyeregger R, Schwalm B, Mauermann M, Pajtler KW, Milde T, Shore ME, Geduldig JE, Pelton K, Czech T, Ashenberg O, Wucherpfennig KW, Rozenblatt-Rosen O, Alexandrescu S, Ligon KL, Pfister SM, Regev A, Slavc I, Berger W, Suvà ML, Kool M, Filbin MG. Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma. Cancer Cell. 2020 07 13; 38(1):44-59.e9. PMID: 32663469.
    Citations: 27     Fields:    Translation:HumansCells
  30. Keywan C, Holm IA, Poduri A, Brownstein CA, Alexandrescu S, Chen J, Geffre C, Goldstein RD. A de novo BRPF1 variant in a case of Sudden Unexplained Death in Childhood. Eur J Med Genet. 2020 Sep; 63(9):104002. PMID: 32652122.
    Citations: 1     Fields:    Translation:Humans
  31. Keywan C, Holm IA, Poduri A, Brownstein CA, Alexandrescu S, Chen J, Geffre C, Goldstein RD. A de novo BRPF1 variant in a case of Sudden Unexplained Death in Childhood. Eur J Med Genet. 2020.
  32. Cacciotti C, Choi J, Alexandrescu S, Zimmerman MA, Cooney TM, Chordas C, Clymer J, Chi S, Yeo KK. Immune checkpoint inhibition for pediatric patients with recurrent/refractory CNS tumors: a single institution experience. J Neurooncol. 2020 Aug; 149(1):113-122. PMID: 32627129.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  33. Ahrendsen J, Alexandrescu S. An Update on Pediatric Gliomas. Surg Pathol Clin. 2020 Jun; 13(2):217-233. PMID: 32389263.
    Citations:    Fields:    Translation:Humans
  34. Touat M, Li YY, Boynton AN, Spurr LF, Iorgulescu JB, Bohrson CL, Cortes-Ciriano I, Birzu C, Geduldig JE, Pelton K, Lim-Fat MJ, Pal S, Ferrer-Luna R, Ramkissoon SH, Dubois F, Bellamy C, Currimjee N, Bonardi J, Qian K, Ho P, Malinowski S, Taquet L, Jones RE, Shetty A, Chow KH, Sharaf R, Pavlick D, Albacker LA, Younan N, Baldini C, Verreault M, Giry M, Guillerm E, Ammari S, Beuvon F, Mokhtari K, Alentorn A, Dehais C, Houillier C, Laigle-Donadey F, Psimaras D, Lee EQ, Nayak L, McFaline-Figueroa JR, Carpentier A, Cornu P, Capelle L, Mathon B, Barnholtz-Sloan JS, Chakravarti A, Bi WL, Chiocca EA, Fehnel KP, Alexandrescu S, Chi SN, Haas-Kogan D, Batchelor TT, Frampton GM, Alexander BM, Huang RY, Ligon AH, Coulet F, Delattre JY, Hoang-Xuan K, Meredith DM, Santagata S, Duval A, Sanson M, Cherniack AD, Wen PY, Reardon DA, Marabelle A, Park PJ, Idbaih A, Beroukhim R, Bandopadhayay P, Bielle F, Ligon KL. Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 04; 580(7804):517-523. PMID: 32322066; PMCID: PMC8235024.
    Citations: 130     Fields:    Translation:HumansAnimalsCells
  35. Blessing MM, Alexandrescu S. Embryonal Tumors of the Central Nervous System: An Update. Surg Pathol Clin. 2020 Jun; 13(2):235-247. PMID: 32389264.
    Citations: 5     Fields:    Translation:Humans
  36. Goss JA, Huang AY, Smith E, Konczyk DJ, Smits PJ, Sudduth CL, Stapleton C, Patel A, Alexandrescu S, Warman ML, Greene AK. Somatic mutations in intracranial arteriovenous malformations. PLoS One. 2019; 14(12):e0226852. PMID: 31891627.
    Citations: 17     Fields:    Translation:HumansCells
  37. Lambo S, Gröbner SN, Rausch T, Waszak SM, Schmidt C, Gorthi A, Romero JC, Mauermann M, Brabetz S, Krausert S, Buchhalter I, Koster J, Zwijnenburg DA, Sill M, Hübner JM, Mack N, Schwalm B, Ryzhova M, Hovestadt V, Papillon-Cavanagh S, Chan JA, Landgraf P, Ho B, Milde T, Witt O, Ecker J, Sahm F, Sumerauer D, Ellison DW, Orr BA, Darabi A, Haberler C, Figarella-Branger D, Wesseling P, Schittenhelm J, Remke M, Taylor MD, Gil-da-Costa MJ, Lastowska M, Grajkowska W, Hasselblatt M, Hauser P, Pietsch T, Uro-Coste E, Bourdeaut F, Masliah-Planchon J, Rigau V, Alexandrescu S, Wolf S, Li XN, Schüller U, Snuderl M, Karajannis MA, Giangaspero F, Jabado N, von Deimling A, Jones DTW, Korbel JO, von Hoff K, Lichter P, Huang A, Bishop AJR, Pfister SM, Korshunov A, Kool M. The molecular landscape of ETMR at diagnosis and relapse. Nature. 2019 12; 576(7786):274-280. PMID: 31802000; PMCID: PMC6908757.
    Citations: 26     Fields:    Translation:Humans
  38. Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG, Shi Y. Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Cancer Cell. 2019 11 11; 36(5):528-544.e10. PMID: 31631026.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  39. Ahrendsen JT, Filbin MG, Chi SN, Manley PE, Wright KD, Bandopadhayay P, Clymer JR, Yeo KK, Kieran MW, Jones R, Lidov HG, Ligon KL, Alexandrescu S. Increasing value of autopsies in patients with brain tumors in the molecular era. J Neurooncol. 2019 Nov; 145(2):349-355. PMID: 31571114.
    Citations: 1     Fields:    Translation:Humans
  40. Chen H, Thomas C, Munoz FA, Alexandrescu S, Horbinski CM, Olar A, McGuone D, Camelo-Piragua S, Wang L, Pentsova E, Phillips J, Aldape K, Chen W, Iafrate AJ, Chi AS, Zagzag D, Golfinos JG, Placantonakis DG, Rosenblum M, Ohman-Strickland P, Hameed M, Snuderl M. Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors. Neuro Oncol. 2019 09 06; 21(9):1164-1174. PMID: 31140557; PMCID: PMC7571489.
    Citations: 5     Fields:    Translation:HumansCells
  41. Torre M, Alexandrescu S, Dubuc AM, Ligon AH, Hornick JL, Meredith DM. Characterization of molecular signatures of supratentorial ependymomas. Mod Pathol. 2020 01; 33(1):47-56. PMID: 31375768.
    Citations: 6     Fields:    Translation:Humans
  42. Benson LA, Li H, Henderson LA, Solomon IH, Soldatos A, Murphy J, Bielekova B, Kennedy AL, Rivkin MJ, Davies KJ, Hsu AP, Holland SM, Gahl WA, Sundel RP, Lehmann LE, Lee MA, Alexandrescu S, Degar BA, Duncan CN, Gorman MP. Pediatric CNS-isolated hemophagocytic lymphohistiocytosis. Neurol Neuroimmunol Neuroinflamm. 2019 05; 6(3):e560. PMID: 31044148.
    Citations: 11     Fields:    Translation:Humans
  43. de Kock L, Priest JR, Foulkes WD, Alexandrescu S. An update on the central nervous system manifestations of DICER1 syndrome. Acta Neuropathol. 2020 04; 139(4):689-701. PMID: 30953130.
    Citations: 14     Fields:    Translation:Humans
  44. Torre M, Meredith DM, Dubuc A, Solomon DA, Perry A, Vasudevaraja V, Serrano J, Snuderl M, Ligon KL, Alexandrescu S. Recurrent EP300-BCOR Fusions in Pediatric Gliomas With Distinct Clinicopathologic Features. J Neuropathol Exp Neurol. 2019 04 01; 78(4):305-314. PMID: 30816933.
    Citations: 6     Fields:    Translation:Humans
  45. Li H, Benson LA, Henderson LA, Solomon IH, Kennedy AL, Soldatos A, Bielekova B, Murphy J, Davies KJ, Lehmann LE, Lee MA, Alexandrescu S, Degar BA, Gorman MP, Duncan CN. Central nervous system-restricted familial hemophagocytic lymphohistiocytosis responds to hematopoietic cell transplantation. Blood Adv. 2019 02 26; 3(4):503-507. PMID: 30760465; PMCID: PMC6391665.
    Citations: 2     Fields:    Translation:Humans
  46. Bichsel CA, Goss J, Alomari M, Alexandrescu S, Robb R, Smith LE, Hochman M, Greene AK, Bischoff J. Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma. JAMA Ophthalmol. 2019 01 01; 137(1):91-95. PMID: 30422215; PMCID: PMC6382586.
    Citations: 12     Fields:    Translation:Humans
  47. Solomon IH, Li H, Benson LA, Henderson LA, Degar BA, Gorman MP, Duncan CN, Lidov HG, Alexandrescu S. Histopathologic Correlates of Familial Hemophagocytic Lymphohistiocytosis Isolated to the Central Nervous System. J Neuropathol Exp Neurol. 2018 12 01; 77(12):1079-1084. PMID: 30295794; PMCID: PMC6658858.
    Citations: 8     Fields:    Translation:Humans
  48. Torre M, Jessop N, Hornick JL, Alexandrescu S. Expanding the spectrum of pediatric NTRK-rearranged fibroblastic tumors to the central nervous system: A case report with RBPMS-NTRK3 fusion. Neuropathology. 2018 Dec; 38(6):624-630. PMID: 30187580.
    Citations: 9     Fields:    Translation:Humans
  49. Alexandrescu S, Paulson V, Dubuc A, Ligon A, Lidov HG. PHOX2B is a reliable immunomarker in distinguishing peripheral neuroblastic tumours from CNS embryonal tumours. Histopathology. 2018 Sep; 73(3):483-491. PMID: 29758594.
    Citations: 1     Fields:    Translation:Humans
  50. Shannon ML, Fame RM, Chau KF, Dani N, Calicchio ML, Géléoc GS, Lidov HGW, Alexandrescu S, Lehtinen MK. Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors. Am J Pathol. 2018 06; 188(6):1334-1344. PMID: 29545198; PMCID: PMC5971223.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  51. Jones DTW, Kieran MW, Bouffet E, Alexandrescu S, Bandopadhayay P, Bornhorst M, Ellison D, Fangusaro J, Fisher MJ, Foreman N, Fouladi M, Hargrave D, Hawkins C, Jabado N, Massimino M, Mueller S, Perilongo G, Schouten van Meeteren AYN, Tabori U, Warren K, Waanders AJ, Walker D, Weiss W, Witt O, Wright K, Zhu Y, Bowers DC, Pfister SM, Packer RJ. Pediatric low-grade gliomas: next biologically driven steps. Neuro Oncol. 2018 01 22; 20(2):160-173. PMID: 29016845; PMCID: PMC5786244.
    Citations: 43     Fields:    Translation:HumansAnimals
  52. Dixit A, Alexandrescu S, Boyer D, Graf EH, Vargas SO, Silverman M. Mycoplasma hominis Empyema in an 18-Year-old Stem Cell and Lung Transplant Recipient: Case Report and Review of the Literature. J Pediatric Infect Dis Soc. 2017 Nov 24; 6(4):e173-e176. PMID: 28992317.
    Citations: 5     Fields:    Translation:HumansCells
  53. Helgager J, Lidov HG, Mahadevan NR, Kieran MW, Ligon KL, Alexandrescu S. A novel GIT2-BRAF fusion in pilocytic astrocytoma. Diagn Pathol. 2017 Nov 15; 12(1):82. PMID: 29141672.
    Citations: 10     Fields:    Translation:HumansCells
  54. Lai PMR, Zaazoue MA, Francois R, Dupervil DG, Berkowitz AL, Alexandrescu S, Proctor MR. Neurenteric cyst at the dorsal craniocervical junction in a child: Case report. J Clin Neurosci. 2018 Feb; 48:86-89. PMID: 29137919.
    Citations: 2     Fields:    Translation:Humans
  55. Karageorgiou E, Naasan G, Pleasure SJ, Alexandrescu S, Gelfand JM, Tammewar G, Miller BL, Rabinovici GD, Grinberg LT. Focal cerebral ß-amyloid angiopathy: A distinct clinicopathologic presentation. Neurol Clin Pract. 2017 Oct; 7(5):444-448. PMID: 29620074; PMCID: PMC5874474.
    Citations:    
  56. Wahl M, Chang SM, Phillips JJ, Molinaro AM, Costello JF, Mazor T, Alexandrescu S, Lupo JM, Nelson SJ, Berger M, Prados M, Taylor JW, Butowski N, Clarke JL, Haas-Kogan D. Probing the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low-grade gliomas. Cancer. 2017 Dec 01; 123(23):4631-4639. PMID: 28759109; PMCID: PMC5693663.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  57. Ramkissoon SH, Bandopadhayay P, Hwang J, Ramkissoon LA, Greenwald NF, Schumacher SE, O'Rourke R, Pinches N, Ho P, Malkin H, Sinai C, Filbin M, Plant A, Bi WL, Chang MS, Yang E, Wright KD, Manley PE, Ducar M, Alexandrescu S, Lidov H, Delalle I, Goumnerova LC, Church AJ, Janeway KA, Harris MH, MacConaill LE, Folkerth RD, Lindeman NI, Stiles CD, Kieran MW, Ligon AH, Santagata S, Dubuc AM, Chi SN, Beroukhim R, Ligon KL. Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. Neuro Oncol. 2017 Jul 01; 19(7):986-996. PMID: 28104717; PMCID: PMC5570190.
    Citations: 36     Fields:    Translation:Humans
  58. Bale TA, Oviedo A, Kozakewich H, Giannini C, Davineni PK, Ligon K, Alexandrescu S. Intracranial myxoid mesenchymal tumors with EWSR1-CREB family gene fusions: myxoid variant of angiomatoid fibrous histiocytoma or novel entity? Brain Pathol. 2018 03; 28(2):183-191. PMID: 28281318.
    Citations: 20     Fields:    Translation:HumansCells
  59. Karageorgiou E, Naasan G, Pleasure SJ, Alexandrescu S, Gelfand JM, Tammewar G, Miller BL, Rabinovici GD, Grinberg LT. Focal cerebral beta-amyloid angiopathy. A distinct clinicopathologic presentation. Neurology Clinical Practice. 2017. View Publication.
  60. Alexandrescu S, Akhavanfard S, Harris MH, Vargas SO. Clinical, Pathologic, and Genetic Features of Wilms Tumors With WTX Gene Mutation. Pediatr Dev Pathol. 2017 Mar-Apr; 20(2):105-111. PMID: 28326956.
    Citations: 2     Fields:    Translation:Humans
  61. Tucker S, Alexandrescu S. Diagnostic Histopathology. Updates and review of neoplastic paediatric neuropathology. 2016; 22(11):431–438.
  62. Alexandrescu S, Tucker S. Diagnostic Histopathology. A review of molecular alterations with clinical impact in adult and paediatric gliomas. 2016; 22(11):439-446.
  63. Huang L, Couto JA, Pinto A, Alexandrescu S, Madsen JR, Greene AK, Sahin M, Bischoff J. Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome. Pediatr Neurol. 2017 02; 67:59-63. PMID: 27919468; PMCID: PMC5303551.
    Citations: 20     Fields:    Translation:HumansCells
  64. Alexandrescu S, Akhavanfard S, Harris MH, Vargas SO. Clinical, pathologic, and genetic features of Wilms tumors with WTX gene mutation. Pediatr Dev Pathol. 2016 Jan 04. PMID: 26727637.
    Citations: 1     Fields:    
  65. Alexandrescu S, Korshunov A, Lai SH, Dabiri S, Patil S, Li R, Shih CS, Bonnin JM, Baker JA, Du E, Scharnhorst DW, Samuel D, Ellison DW, Perry A. Epithelioid Glioblastomas and Anaplastic Epithelioid Pleomorphic Xanthoastrocytomas--Same Entity or First Cousins? Brain Pathol. 2016 Mar; 26(2):215-23. PMID: 26238627.
    Citations: 40     Fields:    Translation:Humans
  66. Alexandrescu S, Orengo JP, Toossi S, Perry A, Treseler P, Hess C, Margeta M. CNS intravascular large cell lymphoma in a patient with autoimmune hemolytic anemia. Neuropathology. 2015 Apr; 35(2):170-4. PMID: 25378202.
    Citations:    Fields:    Translation:Humans
  67. Senniappan S, Alexandrescu S, Tatevian N, Shah P, Arya V, Flanagan S, Ellard S, Rampling D, Ashworth M, Brown RE, Hussain K. Sirolimus therapy in infants with severe hyperinsulinemic hypoglycemia. N Engl J Med. 2014 Mar 20; 370(12):1131-7. PMID: 24645945.
    Citations: 45     Fields:    Translation:Humans
  68. Alexandrescu S, Rosenberg H, Tatevian N. Role of calretinin immunohistochemical stain in evaluation of Hirschsprung disease: an institutional experience. Int J Clin Exp Pathol. 2013; 6(12):2955-61. PMID: 24294384.
    Citations: 9     Fields:    Translation:Humans
  69. Alexandrescu S, Tatevian N, Czerniak BA, Covinsky MH, Burns NK, Brown RE. Morphoproteomics provides support for TGF-ß pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis. Int J Clin Exp Pathol. 2012; 5(6):503-11. PMID: 22949932.
    Citations: 4     Fields:    Translation:HumansCells
  70. Hrehoret D, Alexandrescu S, Grigorie R, Herlea V, Anghel R, Popescu I. Intrahepatic cholangiocarcinoma--a rare indication for liver transplantation. Case report and review of the literature. Chirurgia (Bucur). 2012 Mar-Apr; 107(2):237-42. PMID: 22712355.
    Citations:    Fields:    Translation:Humans
  71. Sargsyan Z, Higgins C, Alexandrescu S, Ott DA, Jain SK. Acute promyelocytic leukemia as a cause of intracoronary drug-eluting-stent thrombosis. Tex Heart Inst J. 2012; 39(3):416-9. PMID: 22719158.
    Citations: 3     Fields:    Translation:Humans
  72. Alexandrescu S, Brown RE, Tandon N, Bhattacharjee MB. Neuron precursor features of spindle cell oncocytoma of adenohypophysis. Ann Clin Lab Sci. 2012; 42(2):123-9. PMID: 22585606.
    Citations: 10     Fields:    Translation:HumansCells
  73. Alexandrescu S, Tatevian N, Olutoye O, Brown RE. Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implications. Int J Clin Exp Pathol. 2010 Aug 08; 3(7):691-705. PMID: 20830240; PMCID: PMC2933389.
    Citations: 15     Fields:    Translation:HumansCells
  74. Guo S, Kowalewska J, Wietecha TA, Iyoda M, Wang L, Yi K, Spencer M, Banas M, Alexandrescu S, Hudkins KL, Alpers CE. Renin-angiotensin system blockade is renoprotective in immune complex-mediated glomerulonephritis. J Am Soc Nephrol. 2008 Jun; 19(6):1168-76. PMID: 18337487.
    Citations: 15     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.