Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Elliot Israel, M.D.

Title
Institution
Department
Address
Phone

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. UG1HL139124 (ISRAEL, ELLIOT) Sep 23, 2017 - Jun 30, 2023
    NIH/NHLBI
    PATINA - Precision Administration of Treatment in Neutrophilic severe Asthma
    Role: Principal Investigator
  2. U10HL109172 (ISRAEL, ELLIOT) Aug 9, 2011 - Jun 30, 2017
    NIH/NHLBI
    AMSA: ALXR/FBR Mediated Signaling in Severe Asthma
    Role: Principal Investigator
  3. U19AI095219 (BOYCE, JOSHUA A) Jul 15, 2011 - Jun 30, 2021
    NIH/NIAID
    Pathophysiologic and Therapeutic Mechanisms in Aspirin Exacerbated Respiratory Disease
    Role: Co-Principal Investigator
  4. P50HL107166 (ISRAEL, ELLIOT) Jun 1, 2011 - May 31, 2014
    NIH/NHLBI
    Lipoxins in Severe Asthma (LIPSA)
    Role: Principal Investigator
  5. U01HL102225 (ISRAEL, ELLIOT) Jun 1, 2010 - May 31, 2014
    NIH/NHLBI
    Kit Inhibition in Asthma (KIA)
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wu W, Bang S, Bleecker ER, Castro M, Denlinger L, Erzurum SC, Fahy JV, Fitzpatrick AM, Gaston BM, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Meyers DA, Moore WC, Peters M, Phillips BR, Phipatanakul W, Sorkness RL, Wenzel SE. Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma. Am J Respir Crit Care Med. 2019 Jun 01; 199(11):1358-1367. PMID: 30682261.
    Citations:    Fields:    
  2. Lazarus SC, Krishnan JA, King TS, Lang JE, Blake KV, Covar R, Lugogo N, Wenzel S, Chinchilli VM, Mauger DT, Dyer AM, Boushey HA, Fahy JV, Woodruff PG, Bacharier LB, Cabana MD, Cardet JC, Castro M, Chmiel J, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Hastie A, Holguin F, Israel E, Jackson D, Kraft M, LaForce C, Lemanske RF, Martinez FD, Moore W, Morgan WJ, Moy JN, Myers R, Peters SP, Phipatanakul W, Pongracic JA, Que L, Ross K, Smith L, Szefler SJ, Wechsler ME, Sorkness CA. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. N Engl J Med. 2019 05 23; 380(21):2009-2019. PMID: 31112384.
    Citations:    
  3. Casale TB, Israel E. Biologics, Clinical Context, and the Asthmas. J Allergy Clin Immunol Pract. 2019 May - Jun; 7(5):1437-1439. PMID: 31076059.
    Citations:    
  4. Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV. Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma. Am J Respir Crit Care Med. 2019 May 01; 199(9):1076-1085. PMID: 30888839.
    Citations:    
  5. Cahill KN, Cui J, Kothari P, Murphy K, Raby BA, Singer J, Israel E, Boyce JA, Laidlaw TM. Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-Exacerbated Respiratory Disease: A Prospective Trial. Am J Respir Crit Care Med. 2019 Apr 12. PMID: 30978291.
    Citations:    
  6. Cardet JC, Jiang X, Lu Q, Gerard N, McIntire K, Boushey HA, Castro M, Chinchilli VM, Codispoti CD, Dyer AM, Holguin F, Kraft M, Lazarus S, Lemanske RF, Lugogo N, Mauger D, Moore WC, Moy J, Ortega VE, Peters SP, Smith LJ, Solway J, Sorkness CA, Sumino K, Wechsler ME, Wenzel S, Israel E. Loss of bronchoprotection with ICS plus LABA treatment, ß-receptor dynamics, and the effect of alendronate. J Allergy Clin Immunol. 2019 Mar 11. PMID: 30872116.
    Citations:    
  7. Kankaanranta H, Israel E. What Patients Can Tell Us About Their Asthma. J Allergy Clin Immunol Pract. 2019 Mar; 7(3):906-907. PMID: 30832895.
    Citations:    
  8. Ramadan AA, Gaffin JM, Israel E, Phipatanakul W. Asthma and Corticosteroid Responses in Childhood and Adult Asthma. Clin Chest Med. 2019 Mar; 40(1):163-177. PMID: 30691710.
    Citations:    Fields:    
  9. Guilbert TW, Bacharier LB, Mauger DT, Phipatanakul W, Szefler SJ, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CD, Cabana MD, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF, Ly N, Meade K, Morgan W, Moy J, Olin JT, Peters SP, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Teague WG, Thyne S, Martinez FD. Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children. J Allergy Clin Immunol. 2019 May; 143(5):1934-1937.e4. PMID: 30660645.
    Citations:    Fields:    
  10. Fitzpatrick AM, Gillespie SE, Mauger DT, Phillips BR, Bleecker ER, Israel E, Meyers DA, Moore WC, Sorkness RL, Wenzel SE, Bacharier LB, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Jarjour NN, Larkin A, Levy BD, Ly NP, Ortega VE, Peters SP, Phipatanakul W, Ramratnam S, Teague WG. Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 2019 Jun; 143(6):2052-2061. PMID: 30635198.
    Citations:    Fields:    
  11. Sorkness CA, King TS, Dyer AM, Chinchilli VM, Mauger DT, Krishnan JA, Blake K, Castro M, Covar R, Israel E, Kraft M, Lang JE, Lugogo N, Peters SP, Wechsler ME, Wenzel SE, Lazarus SC. Adapting clinical trial design to maintain meaningful outcomes during a multicenter asthma trial in the precision medicine era. Contemp Clin Trials. 2019 Feb; 77:98-103. PMID: 30593883.
    Citations:    Fields:    
  12. Yawn BP, Israel E, Wechsler ME, Pace W, Madison S, Manning B, Doros G, Fuhlbrigge A. The asthma Symptom Free Days Questionnaire: how reliable are patient responses? J Asthma. 2018 Oct 26; 1-9. PMID: 30365368.
    Citations:    Fields:    
  13. Cahill KN, Murphy K, Singer J, Israel E, Boyce JA, Laidlaw TM. Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2019 Feb; 143(2):799-803.e2. PMID: 30339852.
    Citations:    Fields:    
  14. Grossman NL, Doros GD, Fandino N, Fuhlbrigge AL, Pace WD, Wechsler ME, Yawn BP, Israel E. Susceptibility to exacerbations in Black adults with asthma. J Asthma. 2019 Jul; 56(7):704-710. PMID: 29969928.
    Citations:    Fields:    
  15. Cardet JC, Codispoti CD, King TS, Bacharier L, Carr T, Castro M, Chinchilli V, Dunn R, Holquing F, Engle L, Nelson K, Ortega VE, Peters M, Ramratnam S, Krishnan JA, Wechsler ME, Israel E. Predictors of inhaled corticosteroid taper failure in adults with asthma. J Allergy Clin Immunol Pract. 2019 Apr; 7(4):1335-1337.e3. PMID: 30240889.
    Citations:    
  16. Kesten S, Israel E, Li G, Mitchell J, Wise R, Stern T. Development of a novel digital breath-activated inhaler: Initial particle size characterization and clinical testing. Pulm Pharmacol Ther. 2018 12; 53:27-32. PMID: 30201410.
    Citations:    
  17. Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD. Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci Immunol. 2018 08 03; 3(26). PMID: 30076281.
    Citations:    Fields:    
  18. Ash SY, Rahaghi FN, Come CE, Ross JC, Colon AG, Cardet-Guisasola JC, Dunican EM, Bleecker ER, Castro M, Fahy JV, Fain SB, Gaston BM, Hoffman EA, Jarjour NN, Mauger DT, Wenzel SE, Levy BD, San Jose Estepar R, Israel E, Washko GR. Pruning of the Pulmonary Vasculature in Asthma. The Severe Asthma Research Program (SARP) Cohort. Am J Respir Crit Care Med. 2018 Jul 01; 198(1):39-50. PMID: 29672122.
    Citations:    Fields:    
  19. Lima JJ, Castro M, King TS, Lang JE, Ortega VE, Peters SP, Denlinger LC, Israel E, Sorkness CA, Wechsler ME, Wenzel SE, Smith LJ. Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial. Ann Allergy Asthma Immunol. 2018 10; 121(4):444-450.e1. PMID: 29908319.
    Citations: 1     Fields:    
  20. Durack J, Huang YJ, Nariya S, Christian LS, Ansel KM, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, King TS, White SR, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Peters SP, Smith LJ, Wechsler ME, Lynch SV, Boushey HA. Bacterial biogeography of adult airways in atopic asthma. Microbiome. 2018 06 09; 6(1):104. PMID: 29885665.
    Citations:    Fields:    Translation:HumansCells
  21. Laidlaw TM, Cahill KN, Cardet JC, Murphy K, Cui J, Dioneda B, Kothari P, Raby BA, Israel E, Boyce JA. A trial of type 12 purinergic (P2Y12) receptor inhibition with prasugrel identifies a potentially distinct endotype of patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2019 Jan; 143(1):316-324.e7. PMID: 29890239.
    Citations:    Fields:    
  22. Nechama M, Kwon J, Wei S, Kyi AT, Welner RS, Ben-Dov IZ, Arredouani MS, Asara JM, Chen CH, Tsai CY, Nelson KF, Kobayashi KS, Israel E, Zhou XZ, Nicholson LK, Lu KP. The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation. Nat Commun. 2018 04 23; 9(1):1603. PMID: 29686383.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  23. Suissa S, Israel E, Donohue J, Evans S, Kemp J. Food and Drug Administration-mandated Trials of Long-Acting ß-Agonist Safety in Asthma. Bang for the Buck? Am J Respir Crit Care Med. 2018 Apr 15; 197(8):987-990. PMID: 29357261.
    Citations:    Fields:    
  24. DeBoer MD, Phillips BR, Mauger DT, Zein J, Erzurum SC, Fitzpatrick AM, Gaston BM, Myers R, Ross KR, Chmiel J, Lee MJ, Fahy JV, Peters M, Ly NP, Wenzel SE, Fajt ML, Holguin F, Moore WC, Peters SP, Meyers D, Bleecker ER, Castro M, Coverstone AM, Bacharier LB, Jarjour NN, Sorkness RL, Ramratnam S, Irani AM, Israel E, Levy B, Phipatanakul W, Gaffin JM, Gerald Teague W. Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma. BMC Pulm Med. 2018 Apr 10; 18(1):58. PMID: 29631584.
    Citations:    Fields:    
  25. Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2018 03 22; 3(6). PMID: 29563345.
    Citations:    Fields:    
  26. Peters MC, Kerr S, Dunican EM, Woodruff PG, Fajt ML, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Wenzel SE, Fahy JV. Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids. J Allergy Clin Immunol. 2019 Jan; 143(1):104-113.e14. PMID: 29524537.
    Citations:    Fields:    
  27. Jackson DJ, Bacharier LB, Mauger DT, Boehmer S, Beigelman A, Chmiel JF, Fitzpatrick AM, Gaffin JM, Morgan WJ, Peters SP, Phipatanakul W, Sheehan WJ, Cabana MD, Holguin F, Martinez FD, Pongracic JA, Baxi SN, Benson M, Blake K, Covar R, Gentile DA, Israel E, Krishnan JA, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Long D, Ly N, Marbin J, Moy JN, Myers RE, Olin JT, Raissy HH, Robison RG, Ross K, Sorkness CA, Lemanske RF. Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations. N Engl J Med. 2018 Mar 08; 378(10):891-901. PMID: 29504498.
    Citations:    Fields:    Translation:Humans
  28. Lipworth B, Israel E. Asthma Step-Down Strategies: Perhaps the Patient Should Decide? J Allergy Clin Immunol Pract. 2018 Mar - Apr; 6(2):644-645. PMID: 29524998.
    Citations:    Fields:    
  29. Olenich S, Waterworth G, Badger GJ, Levy B, Israel E, Langevin HM. Flexibility and strength training in asthma: A pilot study. J Asthma. 2018 Dec; 55(12):1376-1383. PMID: 29420095.
    Citations:    Fields:    
  30. Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER, Phillips BR, Mauger DT, Gordon ED, Woodruff PG, Peters MC, Fahy JV. Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest. 2018 Mar 01; 128(3):997-1009. PMID: 29400693.
    Citations: 7     Fields:    
  31. Panganiban RA, Sun M, Dahlin A, Park HR, Kan M, Himes BE, Mitchel JA, Iribarren C, Jorgenson E, Randell SH, Israel E, Tantisira K, Shore S, Park JA, Weiss ST, Wu AC, Lu Q. A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis. J Allergy Clin Immunol. 2018 Nov; 142(5):1469-1478.e2. PMID: 29330013.
    Citations: 1     Fields:    
  32. Hillyer EV, Price DB, Chrystyn H, Martin RJ, Israel E, van Aalderen WMC, Papi A, Usmani OS, Roche N. Harmonizing the Nomenclature for Therapeutic Aerosol Particle Size: A Proposal. J Aerosol Med Pulm Drug Deliv. 2018 04; 31(2):111-113. PMID: 29182483.
    Citations: 1     Fields:    
  33. Israel E, Panettieri RA. Anti-IgE or Anti-IL5: That Is the Question. J Allergy Clin Immunol Pract. 2018 May - Jun; 6(3):782-784. PMID: 29150253.
    Citations:    Fields:    
  34. Wong-McGrath K, Denlinger LC, Bleecker ER, Castro M, Gaston B, Israel E, Jarjour NN, Mauger DT, Peters S, Phillips BR, Wenzel SE, Fahy JV, Peters MC. Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control. Chest. 2018 Feb; 153(2):378-386. PMID: 29080709.
    Citations:    Fields:    
  35. Sonnappa S, McQueen B, Postma DS, Martin RJ, Roche N, Grigg J, Guilbert T, Gouder C, Pizzichini E, Niimi A, Phipatanakul W, Chisholm A, Dandurand RJ, Kaplan A, Israel E, Papi A, van Aalderen WMC, Usmani OS, Price DB. Extrafine Versus Fine Inhaled Corticosteroids in Relation to Asthma Control: A Systematic Review and Meta-Analysis of Observational Real-Life Studies. J Allergy Clin Immunol Pract. 2018 May - Jun; 6(3):907-915.e7. PMID: 28941668.
    Citations: 1     Fields:    
  36. Israel E, Reddel HK. Severe and Difficult-to-Treat Asthma in Adults. N Engl J Med. 2017 Sep 07; 377(10):965-976. PMID: 28877019.
    Citations: 7     Fields:    Translation:Humans
  37. Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN. Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. J Allergy Clin Immunol Pract. 2018 Mar - Apr; 6(2):545-554.e4. PMID: 28866107.
    Citations: 3     Fields:    
  38. Cahill KN, Boyce JA, Israel E. Novel Treatments for Airway Disease. N Engl J Med. 2017 08 10; 377(6):597. PMID: 28813135.
    Citations:    Fields:    
  39. Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2017 Jul 20; 2(14). PMID: 28724795.
    Citations:    Fields:    
  40. Lugogo N, Green CL, Agada N, Zhang S, Meghdadpour S, Zhou R, Yang S, Anstrom KJ, Israel E, Martin R, Lemanske RF, Boushey H, Lazarus SC, Wasserman SI, Castro M, Calhoun W, Peters SP, DiMango E, Chinchilli V, Kunselman S, King TS, Icitovic N, Kraft M. Obesity's effect on asthma extends to diagnostic criteria. J Allergy Clin Immunol. 2018 Mar; 141(3):1096-1104. PMID: 28624608.
    Citations:    Fields:    
  41. Sonnappa S, Martin R, Israel E, Postma D, van Aalderen W, Burden A, Usmani OS, Price DB. Risk of pneumonia in obstructive lung disease: A real-life study comparing extra-fine and fine-particle inhaled corticosteroids. PLoS One. 2017; 12(6):e0178112. PMID: 28617814.
    Citations: 1     Fields:    Translation:Humans
  42. Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E. Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma. Am J Respir Crit Care Med. 2017 06 01; 195(11):1439-1448. PMID: 27967215.
    Citations: 7     Fields:    Translation:Humans
  43. Cardet JC, Louisias M, King TS, Castro M, Codispoti CD, Dunn R, Engle L, Giles BL, Holguin F, Lima JJ, Long D, Lugogo N, Nyenhuis S, Ortega VE, Ramratnam S, Wechsler ME, Israel E, Phipatanakul W. Income is an independent risk factor for worse asthma outcomes. J Allergy Clin Immunol. 2018 Feb; 141(2):754-760.e3. PMID: 28535964.
    Citations: 1     Fields:    
  44. Cahill KN, Katz HR, Cui J, Lai J, Kazani S, Crosby-Thompson A, Garofalo D, Castro M, Jarjour N, DiMango E, Erzurum S, Trevor JL, Shenoy K, Chinchilli VM, Wechsler ME, Laidlaw TM, Boyce JA, Israel E. KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma. N Engl J Med. 2017 05 18; 376(20):1911-1920. PMID: 28514613.
    Citations: 8     Fields:    Translation:HumansCells
  45. Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD. Natural killer cell-mediated inflammation resolution is disabled in severe asthma. Sci Immunol. 2017 Mar 10; 2(9). PMID: 28783702.
    Citations: 2     Fields:    
  46. Postma DS, Dekhuijzen R, van der Molen T, Martin RJ, van Aalderen W, Roche N, Guilbert TW, Israel E, van Eickels D, Khalid JM, Herings RM, Overbeek JA, Miglio C, Thomas V, Hutton C, Hillyer EV, Price DB. Asthma-Related Outcomes in Patients Initiating Extrafine Ciclesonide or Fine-Particle Inhaled Corticosteroids. Allergy Asthma Immunol Res. 2017 Mar; 9(2):116-125. PMID: 28102056.
    Citations: 3     
  47. Chipps BE, Corren J, Israel E, Katial R, Lang DM, Panettieri RA, Peters SP, Farrar JR. Asthma Yardstick: Practical recommendations for a sustained step-up in asthma therapy for poorly controlled asthma. Ann Allergy Asthma Immunol. 2017 02; 118(2):133-142.e3. PMID: 28153079.
    Citations: 2     Fields:    Translation:HumansCells
  48. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN. Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med. 2017 02 01; 195(3):302-313. PMID: 27556234.
    Citations: 18     Fields:    Translation:HumansCellsCTClinical Trials
  49. Guilbert TW, Colice G, Grigg J, van Aalderen W, Martin RJ, Israel E, Postma DS, Roche N, Phipatanakul W, Hillyer EV, Evans JM, Dolovich MB, Price DB. Real-Life Outcomes for Patients with Asthma Prescribed Spacers for Use with Either Extrafine- or Fine-Particle Inhaled Corticosteroids. J Allergy Clin Immunol Pract. 2017 Jul - Aug; 5(4):1040-1049.e4. PMID: 28110057.
    Citations: 1     Fields:    Translation:Humans
  50. Nyenhuis SM, Krishnan JA, Berry A, Calhoun WJ, Chinchilli VM, Engle L, Grossman N, Holguin F, Israel E, Kittles RA, Kraft M, Lazarus SC, Lehman EB, Mauger DT, Moy JN, Peters SP, Phipatanakul W, Smith LJ, Sumino K, Szefler SJ, Wechsler ME, Wenzel S, White SR, Ackerman SJ. Race is associated with differences in airway inflammation in patients with asthma. J Allergy Clin Immunol. 2017 Jul; 140(1):257-265.e11. PMID: 28069248.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  51. Durack J, Lynch SV, Nariya S, Bhakta NR, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, Sharp-King T, White SR, Woodruff PG, Avila PC, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Moore WC, Peters SP, Que L, Smith LJ, Sorkness CA, Wechsler ME, Wenzel SE, Boushey HA, Huang YJ. Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol. 2017 Jul; 140(1):63-75. PMID: 27838347.
    Citations: 18     Fields:    Translation:HumansCells
  52. Fitzpatrick AM, Jackson DJ, Mauger DT, Boehmer SJ, Phipatanakul W, Sheehan WJ, Moy JN, Paul IM, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan W, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Szefler SJ. Individualized therapy for persistent asthma in young children. J Allergy Clin Immunol. 2016 12; 138(6):1608-1618.e12. PMID: 27777180.
    Citations: 7     Fields:    Translation:Humans
  53. Luyster FS, Strollo PJ, Holguin F, Castro M, Dunican EM, Fahy J, Gaston B, Israel E, Jarjour NN, Mauger DT, Moore WC, Wenzel SE. Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III. Chest. 2016 Dec; 150(6):1242-1250. PMID: 27720882.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  54. Girodet PO, Nguyen D, Mancini JD, Hundal M, Zhou X, Israel E, Cernadas M. Alternative Macrophage Activation Is Increased in Asthma. Am J Respir Cell Mol Biol. 2016 Oct; 55(4):467-475. PMID: 27248771.
    Citations: 12     Fields:    
  55. Sheehan WJ, Mauger DT, Paul IM, Moy JN, Boehmer SJ, Szefler SJ, Fitzpatrick AM, Jackson DJ, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan WJ, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Wechsler ME, Phipatanakul W. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. N Engl J Med. 2016 Aug 18; 375(7):619-30. PMID: 27532828.
    Citations: 9     Fields:    Translation:Humans
  56. van der Molen T, Postma DS, Martin RJ, Herings RM, Overbeek JA, Thomas V, Miglio C, Dekhuijzen R, Roche N, Guilbert T, Israel E, van Aalderen W, Hillyer EV, van Rysewyk S, Price DB. Erratum to: Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands. BMC Pulm Med. 2016 Jul 23; 16(1):105. PMID: 27450521.
    Citations:    Fields:    
  57. Zein JG, Udeh BL, Teague WG, Koroukian SM, Schlitz NK, Bleecker ER, Busse WB, Calhoun WJ, Castro M, Comhair SA, Fitzpatrick AM, Israel E, Wenzel SE, Holguin F, Gaston BM, Erzurum SC. Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012. PLoS One. 2016; 11(6):e0157301. PMID: 27294365.
    Citations: 4     Fields:    Translation:Humans
  58. Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV. Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Lancet Respir Med. 2016 07; 4(7):574-584. PMID: 27283230.
    Citations: 19     Fields:    Translation:Humans
  59. Price DB, Colice G, Israel E, Roche N, Postma DS, Guilbert TW, van Aalderen WM, Grigg J, Hillyer EV, Thomas V, Martin RJ. Add-on LABA in a separate inhaler as asthma step-up therapy versus increased dose of ICS or ICS/LABA combination inhaler. ERJ Open Res. 2016 Apr; 2(2). PMID: 27730200.
    Citations: 2     
  60. van der Molen T, Postma DS, Martin RJ, Herings RM, Overbeek JA, Thomas V, Miglio C, Dekhuijzen R, Roche N, Guilbert T, Israel E, van Aalderen W, Hillyer EV, van Rysewyk S, Price DB. Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands. BMC Pulm Med. 2016 May 17; 16(1):80. PMID: 27184175.
    Citations: 3     Fields:    Translation:Humans
  61. Cardet JC, Ash S, Kusa T, Camargo CA, Israel E. Insulin resistance modifies the association between obesity and current asthma in adults. Eur Respir J. 2016 08; 48(2):403-10. PMID: 27103388.
    Citations: 4     Fields:    Translation:Humans
  62. Mitchel JA, Antoniak S, Lee JH, Kim SH, McGill M, Kasahara DI, Randell SH, Israel E, Shore SA, Mackman N, Park JA. IL-13 Augments Compressive Stress-Induced Tissue Factor Expression in Human Airway Epithelial Cells. Am J Respir Cell Mol Biol. 2016 Apr; 54(4):524-31. PMID: 26407210.
    Citations: 1     Fields:    Translation:HumansCells
  63. Park JA, Mitchel JA, Qazvini NT, Kim JH, Park CY, Butler JP, Israel E, Randell SH, Shore SA, Drazen JM, Fredberg JJ. Compressive Stress Causes an Unjamming Transition and an Epithelial-Mesenchymal Transition in the Airway Epithelium in Asthma. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S102. PMID: 27027941.
    Citations:    Fields:    
  64. Reid B, Girodet PO, Boomer JS, Abdel-Gadir A, Zheng K, Wechsler ME, Bacharier LB, Kunselman SJ, King TS, Israel E, Castro M, Cernadas M, Green JM. Vitamin D3 treatment of vitamin D-insufficient asthmatic patients does not alter immune cell function. J Allergy Clin Immunol. 2016 07; 138(1):286-289.e9. PMID: 26874367.
    Citations: 1     Fields:    Translation:HumansCells
  65. Riley CM, Wenzel SE, Castro M, Erzurum SC, Chung KF, Fitzpatrick AM, Gaston B, Israel E, Moore WC, Bleecker ER, Calhoun WJ, Jarjour NN, Busse WW, Peters SP, Teague WG, Sorkness R, Holguin F. Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma. PLoS One. 2015; 10(12):e0145476. PMID: 26717486.
    Citations: 4     Fields:    Translation:Humans
  66. Buchheit KM, Cahill KN, Katz HR, Murphy KC, Feng C, Lee-Sarwar K, Lai J, Bhattacharyya N, Israel E, Boyce JA, Laidlaw TM. Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2016 05; 137(5):1566-1576.e5. PMID: 26691435.
    Citations: 15     Fields:    Translation:HumansCells
  67. Bacharier LB, Guilbert TW, Mauger DT, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CD, Cabana M, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF, Ly N, Meade K, Morgan W, Moy J, Olin T, Peters SP, Phipatanakul W, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Szefler SJ, Teague WG, Thyne S, Martinez FD. Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial. JAMA. 2015 Nov 17; 314(19):2034-2044. PMID: 26575060.
    Citations: 16     Fields:    Translation:HumansPHPublic Health
  68. Wechsler ME, Yawn BP, Fuhlbrigge AL, Pace WD, Pencina MJ, Doros G, Kazani S, Raby BA, Lanzillotti J, Madison S, Israel E. Anticholinergic vs Long-Acting ß-Agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma: The BELT Randomized Clinical Trial. JAMA. 2015 Oct 27; 314(16):1720-30. PMID: 26505596.
    Citations: 6     Fields:    Translation:Humans
  69. Dunn RM, Lehman E, Chinchilli VM, Martin RJ, Boushey HA, Israel E, Kraft M, Lazarus SC, Lemanske RF, Lugogo NL, Peters SP, Sorkness CA, Szefler S, Wechsler ME. Impact of Age and Sex on Response to Asthma Therapy. Am J Respir Crit Care Med. 2015 Sep 01; 192(5):551-8. PMID: 26068329.
    Citations: 5     Fields:    Translation:Humans
  70. Park JA, Kim JH, Bi D, Mitchel JA, Qazvini NT, Tantisira K, Park CY, McGill M, Kim SH, Gweon B, Notbohm J, Steward R, Burger S, Randell SH, Kho AT, Tambe DT, Hardin C, Shore SA, Israel E, Weitz DA, Tschumperlin DJ, Henske EP, Weiss ST, Manning ML, Butler JP, Drazen JM, Fredberg JJ. Unjamming and cell shape in the asthmatic airway epithelium. Nat Mater. 2015 Oct; 14(10):1040-8. PMID: 26237129.
    Citations: 24     Fields:    Translation:HumansCells
  71. Zein JG, Dweik RA, Comhair SA, Bleecker ER, Moore WC, Peters SP, Busse WW, Jarjour NN, Calhoun WJ, Castro M, Chung KF, Fitzpatrick A, Israel E, Teague WG, Wenzel SE, Love TE, Gaston BM, Erzurum SC. Asthma Is More Severe in Older Adults. PLoS One. 2015; 10(7):e0133490. PMID: 26200463.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  72. Sumino K, Israel E. Precision Medicine. Personalizing Guidelines to the Provider as Well as the Patient: Making the Juice Worth the Squeeze. Am J Respir Crit Care Med. 2015 Jun 15; 191(12):1345-6. PMID: 26075416.
    Citations: 1     Fields:    Translation:Humans
  73. Israel E, Roche N, Martin RJ, Colice G, Dorinsky PM, Postma DS, Guilbert TW, van Aalderen WM, Grigg J, Hillyer EV, Burden A, von Ziegenweidt J, Thomas V, Price DB. Increased Dose of Inhaled Corticosteroid versus Add-On Long-acting ß-Agonist for Step-Up Therapy in Asthma. Ann Am Thorac Soc. 2015 Jun; 12(6):798-806. PMID: 25756308.
    Citations: 6     Fields:    Translation:Humans
  74. van Aalderen WM, Grigg J, Guilbert TW, Roche N, Israel E, Martin RJ, Colice G, Postma DS, Hillyer EV, Burden A, Thomas V, von Ziegenweidt J, Price D. Small-particle Inhaled Corticosteroid as First-line or Step-up Controller Therapy in Childhood Asthma. J Allergy Clin Immunol Pract. 2015 Sep-Oct; 3(5):721-31.e16. PMID: 26032474.
    Citations: 5     Fields:    Translation:Humans
  75. Roche N, Postma DS, Colice G, Burden A, Guilbert TW, Israel E, Martin RJ, van Aalderen WM, Grigg J, Hillyer EV, von Ziegenweidt J, Price DB. Differential effects of inhaled corticosteroids in smokers/ex-smokers and nonsmokers with asthma. Am J Respir Crit Care Med. 2015 Apr 15; 191(8):960-4. PMID: 25876207.
    Citations: 6     Fields:    Translation:Humans
  76. Israel E, Lasky-Su J, Markezich A, Damask A, Szefler SJ, Schuemann B, Klanderman B, Sylvia J, Kazani S, Wu R, Martinez F, Boushey HA, Chinchilli VM, Mauger D, Weiss ST, Tantisira KG. Genome-wide association study of short-acting ß2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3. Am J Respir Crit Care Med. 2015 Mar 01; 191(5):530-7. PMID: 25562107.
    Citations: 2     Fields:    Translation:HumansCells
  77. Cardet JC, Israel E. Update on reslizumab for eosinophilic asthma. Expert Opin Biol Ther. 2015; 15(10):1531-9. PMID: 26372797.
    Citations: 7     Fields:    Translation:HumansCells
  78. Kazani S, Arm JP, Boyce J, Chhay H, Dutile S, Wechsler ME, Govindarajulu U, Ivester P, Ainsworth HC, Sergeant S, Chilton FH, Israel E. LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma. Springerplus. 2014; 3:661. PMID: 25485197.
    Citations: 2     
  79. Postma DS, Roche N, Colice G, Israel E, Martin RJ, van Aalderen WM, Grigg J, Burden A, Hillyer EV, von Ziegenweidt J, Gopalan G, Price D. Comparing the effectiveness of small-particle versus large-particle inhaled corticosteroid in COPD. Int J Chron Obstruct Pulmon Dis. 2014; 9:1163-86. PMID: 25378918.
    Citations: 6     Fields:    Translation:Humans
  80. Ono E, Dutile S, Kazani S, Wechsler ME, Yang J, Hammock BD, Douda DN, Tabet Y, Khaddaj-Mallat R, Sirois M, Sirois C, Rizcallah E, Rousseau E, Martin R, Sutherland ER, Castro M, Jarjour NN, Israel E, Levy BD. Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. Am J Respir Crit Care Med. 2014 Oct 15; 190(8):886-97. PMID: 25162465.
    Citations: 6     Fields:    Translation:Humans
  81. Martin RJ, Price D, Roche N, Israel E, van Aalderen WM, Grigg J, Postma DS, Guilbert TW, Hillyer EV, Burden A, von Ziegenweidt J, Colice G. Cost-effectiveness of initiating extrafine- or standard size-particle inhaled corticosteroid for asthma in two health-care systems: a retrospective matched cohort study. NPJ Prim Care Respir Med. 2014 Oct 09; 24:14081. PMID: 25297072.
    Citations: 7     Fields:    Translation:Humans
  82. Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, Kazani SD, Moore WC, Moy J, Sorkness CA, Avila P, Bacharier LB, Bleecker E, Boushey HA, Chmiel J, Fitzpatrick AM, Gentile D, Hundal M, Israel E, Kraft M, Krishnan JA, LaForce C, Lazarus SC, Lemanske R, Lugogo N, Martin RJ, Mauger DT, Naureckas E, Peters SP, Phipatanakul W, Que LG, Sheshadri A, Smith L, Solway J, Sullivan-Vedder L, Sumino K, Wechsler ME, Wenzel S, White SR, Sutherland ER. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA. 2014 May; 311(20):2083-91. PMID: 24838406.
    Citations: 55     Fields:    Translation:Humans
  83. Israel E, Papi A. Severe asthma: pragmatic clinical lumping and time for investigational splitting. Am J Respir Crit Care Med. 2014 Mar 15; 189(6):619-20. PMID: 24628307.
    Citations:    Fields:    Translation:Humans
  84. Wu W, Bleecker E, Moore W, Busse WW, Castro M, Chung KF, Calhoun WJ, Erzurum S, Gaston B, Israel E, Curran-Everett D, Wenzel SE. Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. J Allergy Clin Immunol. 2014 May; 133(5):1280-8. PMID: 24589344.
    Citations: 41     Fields:    Translation:HumansCTClinical Trials
  85. Kazani S, Israel E. Reply: "The intrinsic bias of generalizations" and "Far from 'disappointing'". Am J Respir Crit Care Med. 2014 Feb 01; 189(3):361-2. PMID: 24484336.
    Citations:    Fields:    Translation:Humans
  86. Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D, Erzurum SC, Israel E, Montealegre F, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting ß agonist treatment in a multiethnic asthma population: a genetic study. Lancet Respir Med. 2014 Mar; 2(3):204-13. PMID: 24621682.
    Citations: 10     Fields:    Translation:Humans
  87. Li C, Lee PS, Sun Y, Gu X, Zhang E, Guo Y, Wu CL, Auricchio N, Priolo C, Li J, Csibi A, Parkhitko A, Morrison T, Planaguma A, Kazani S, Israel E, Xu KF, Henske EP, Blenis J, Levy BD, Kwiatkowski D, Yu JJ. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. J Exp Med. 2014 Jan 13; 211(1):15-28. PMID: 24395886.
    Citations: 21     Fields:    Translation:HumansAnimals
  88. Kim HY, Lee HJ, Chang YJ, Pichavant M, Shore SA, Fitzgerald KA, Iwakura Y, Israel E, Bolger K, Faul J, DeKruyff RH, Umetsu DT. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat Med. 2014 Jan; 20(1):54-61. PMID: 24336249.
    Citations: 128     Fields:    Translation:AnimalsCells
  89. Bonini M, Permaul P, Kulkarni T, Kazani S, Segal A, Sorkness CA, Wechsler ME, Israel E. Loss of salmeterol bronchoprotection against exercise in relation to ADRB2 Arg16Gly polymorphism and exhaled nitric oxide. Am J Respir Crit Care Med. 2013 Dec 15; 188(12):1407-12. PMID: 24228710.
    Citations: 8     Fields:    Translation:Humans
  90. Wysocki K, Park SY, Bleecker E, Busse W, Castro M, Chung KF, Gaston B, Erzurum S, Israel E, Teague WG, Moore CG, Wenzel S. Characterization of factors associated with systemic corticosteroid use in severe asthma: data from the Severe Asthma Research Program. J Allergy Clin Immunol. 2014 Mar; 133(3):915-8. PMID: 24332222.
    Citations: 8     Fields:    Translation:Humans
  91. Rabe KF, Fabbri LM, Israel E, Kögler H, Riemann K, Schmidt H, Glaab T, Vogelmeier CF. Effect of ADRB2 polymorphisms on the efficacy of salmeterol and tiotropium in preventing COPD exacerbations: a prespecified substudy of the POET-COPD trial. Lancet Respir Med. 2014 Jan; 2(1):44-53. PMID: 24461901.
    Citations: 5     Fields:    Translation:Humans
  92. Roche N, Reddel HK, Agusti A, Bateman ED, Krishnan JA, Martin RJ, Papi A, Postma D, Thomas M, Brusselle G, Israel E, Rand C, Chisholm A, Price D. Integrating real-life studies in the global therapeutic research framework. Lancet Respir Med. 2013 Dec; 1(10):e29-30. PMID: 24461762.
    Citations: 24     Fields:    Translation:Humans
  93. Gaffin JM, Bouzaher A, McCown M, Larabee Tuttle K, Israel E, Phipatanakul W. Rethinking the prevalence of exercise-induced bronchoconstriction in patients with asthma. Ann Allergy Asthma Immunol. 2013 Dec; 111(6):567-8. PMID: 24267370.
    Citations:    Fields:    Translation:Humans
  94. Arm JP, Boyce JA, Wang L, Chhay H, Zahid M, Patil V, Govindarajulu U, Ivester P, Weaver KL, Sergeant S, Israel E, Chilton FH. Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. Lipids Health Dis. 2013 Oct 02; 12:141. PMID: 24088297.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  95. Peters SP, Bleecker ER, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger LC, Engle LL, Dimango EA, Israel E, Kraft M, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Ramsdell J, Sorkness CA, Sutherland ER, Wasserman SI, Walter MJ, Wechsler ME, Chinchilli VM, Szefler SJ. Predictors of response to tiotropium versus salmeterol in asthmatic adults. J Allergy Clin Immunol. 2013 Nov; 132(5):1068-1074.e1. PMID: 24084072.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  96. Himes BE, Qiu W, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF, Zeiger RS, Strunk RC, Martinez FD, Boushey H, Chinchilli VM, Israel E, Mauger D, Koppelman GH, Nieuwenhuis MA, Postma DS, Vonk JM, Rafaels N, Hansel NN, Barnes K, Raby B, Tantisira KG, Weiss ST. ITGB5 and AGFG1 variants are associated with severity of airway responsiveness. BMC Med Genet. 2013 Aug 28; 14:86. PMID: 23984888.
    Citations: 3     Fields:    Translation:Humans
  97. Kazani S, Israel E. What doesn't kill may not make you stronger. ß-blockers for asthma. Am J Respir Crit Care Med. 2013 Jun 15; 187(12):1281. PMID: 23767898.
    Citations:    
  98. Knolle MD, Nakajima T, Hergrueter A, Gupta K, Polverino F, Craig VJ, Fyfe SE, Zahid M, Permaul P, Cernadas M, Montano G, Tesfaigzi Y, Sholl L, Kobzik L, Israel E, Owen CA. Adam8 limits the development of allergic airway inflammation in mice. J Immunol. 2013 Jun 15; 190(12):6434-49. PMID: 23670189.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  99. Sznajder JI, Brochard L, Budinger GR, Erzurum SC, Israel E, Schumacker P. Process and impact as the Journal moves forward. Am J Respir Crit Care Med. 2013 May 01; 187(9):897-8. PMID: 23634852.
    Citations:    Fields:    Translation:Humans
  100. Kazani S, Planaguma A, Ono E, Bonini M, Zahid M, Marigowda G, Wechsler ME, Levy BD, Israel E. Exhaled breath condensate eicosanoid levels associate with asthma and its severity. J Allergy Clin Immunol. 2013 Sep; 132(3):547-553. PMID: 23608729.
    Citations: 22     Fields:    Translation:Humans
  101. Colice G, Martin RJ, Israel E, Roche N, Barnes N, Burden A, Polos P, Dorinsky P, Hillyer EV, Lee AJ, Chisholm A, von Ziegenweidt J, Barion F, Price D. Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone. J Allergy Clin Immunol. 2013 Jul; 132(1):45-54. PMID: 23591272.
    Citations: 14     Fields:    Translation:Humans
  102. Rao CK, Moore CG, Bleecker E, Busse WW, Calhoun W, Castro M, Chung KF, Erzurum SC, Israel E, Curran-Everett D, Wenzel SE. Characteristics of perimenstrual asthma and its relation to asthma severity and control: data from the Severe Asthma Research Program. Chest. 2013 Apr; 143(4):984-992. PMID: 23632943.
    Citations: 11     Fields:    Translation:Humans
  103. Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol. 2013 Aug; 132(2):313-20.e15. PMID: 23541324.
    Citations: 28     Fields:    Translation:HumansCells
  104. Barnig C, Cernadas M, Dutile S, Liu X, Perrella MA, Kazani S, Wechsler ME, Israel E, Levy BD. Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med. 2013 Feb 27; 5(174):174ra26. PMID: 23447017.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  105. Himes BE, Sheppard K, Berndt A, Leme AS, Myers RA, Gignoux CR, Levin AM, Gauderman WJ, Yang JJ, Mathias RA, Romieu I, Torgerson DG, Roth LA, Huntsman S, Eng C, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF, Zeiger RS, Strunk RC, Martinez FD, Boushey H, Chinchilli VM, Israel E, Mauger D, Koppelman GH, Postma DS, Nieuwenhuis MA, Vonk JM, Lima JJ, Irvin CG, Peters SP, Kubo M, Tamari M, Nakamura Y, Litonjua AA, Tantisira KG, Raby BA, Bleecker ER, Meyers DA, London SJ, Barnes KC, Gilliland FD, Williams LK, Burchard EG, Nicolae DL, Ober C, DeMeo DL, Silverman EK, Paigen B, Churchill G, Shapiro SD, Weiss ST. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One. 2013; 8(2):e56179. PMID: 23457522.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  106. Holguin F, Comhair SA, Hazen SL, Powers RW, Khatri SS, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Chung KF, Erzurum SC, Wenzel SE. An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. Am J Respir Crit Care Med. 2013 Jan 15; 187(2):153-9. PMID: 23204252.
    Citations: 43     Fields:    Translation:Humans
  107. Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA, Peters SP, Sheerar D, Shi L, Sutherland ER, Szefler SJ, Wechsler ME, Sorkness CA, Lemanske RF. P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Am J Respir Crit Care Med. 2013 Jan 01; 187(1):28-33. PMID: 23144325.
    Citations: 7     Fields:    Translation:HumansCells
  108. Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Boushey HA. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA. 2012 Sep 12; 308(10):987-97. PMID: 22968888.
    Citations: 21     Fields:    Translation:Humans
  109. Himes BE, Jiang X, Hu R, Wu AC, Lasky-Su JA, Klanderman BJ, Ziniti J, Senter-Sylvia J, Lima JJ, Irvin CG, Peters SP, Meyers DA, Bleecker ER, Kubo M, Tamari M, Nakamura Y, Szefler SJ, Lemanske RF, Zeiger RS, Strunk RC, Martinez FD, Hanrahan JP, Koppelman GH, Postma DS, Nieuwenhuis MA, Vonk JM, Panettieri RA, Markezich A, Israel E, Carey VJ, Tantisira KG, Litonjua AA, Lu Q, Weiss ST. Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. PLoS Genet. 2012 Jul; 8(7):e1002824. PMID: 22792082.
    Citations: 28     Fields:    Translation:HumansCells
  110. Kazani S, Israel E. Update in asthma 2011. Am J Respir Crit Care Med. 2012 Jul 01; 186(1):35-40. PMID: 22753688.
    Citations: 7     Fields:    Translation:HumansCells
  111. Li X, Ampleford EJ, Howard TD, Moore WC, Torgerson DG, Li H, Busse WW, Castro M, Erzurum SC, Israel E, Nicolae DL, Ober C, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol. 2012 Oct; 130(4):861-8.e7. PMID: 22694930.
    Citations: 33     Fields:    Translation:Humans
  112. Torgerson DG, Capurso D, Ampleford EJ, Li X, Moore WC, Gignoux CR, Hu D, Eng C, Mathias RA, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Rodríguez-Santana JR, Rodríguez-Cintrón W, Avila PC, Ford JG, Barnes KC, Burchard EG, Howard TD, Bleecker ER, Meyers DA, Cox NJ, Ober C, Nicolae DL. Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects. J Allergy Clin Immunol. 2012 Sep; 130(3):622-629.e9. PMID: 22607992.
    Citations: 16     Fields:    Translation:HumansCells
  113. Szefler SJ, Chinchilli VM, Israel E, Denlinger LC, Lemanske RF, Calhoun W, Peters SP. Key observations from the NHLBI Asthma Clinical Research Network. Thorax. 2012 May; 67(5):450-5. PMID: 22514237.
    Citations: 6     Fields:    Translation:Humans
  114. Tantisira KG, Damask A, Szefler SJ, Schuemann B, Markezich A, Su J, Klanderman B, Sylvia J, Wu R, Martinez F, Boushey HA, Chinchilli VM, Mauger D, Weiss ST, Israel E. Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus. Am J Respir Crit Care Med. 2012 Jun 15; 185(12):1286-91. PMID: 22538805.
    Citations: 19     Fields:    Translation:Humans
  115. Kazani S, Israel E. Utility of exhaled breath condensates across respiratory diseases. Am J Respir Crit Care Med. 2012 Apr 15; 185(8):791-2. PMID: 22505746.
    Citations: 3     Fields:    Translation:Humans
  116. Luyster FS, Teodorescu M, Bleecker E, Busse W, Calhoun W, Castro M, Chung KF, Erzurum S, Israel E, Strollo PJ, Wenzel SE. Sleep quality and asthma control and quality of life in non-severe and severe asthma. Sleep Breath. 2012 Dec; 16(4):1129-37. PMID: 22102290.
    Citations: 20     Fields:    Translation:Humans
  117. Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP, Sorkness RL, Teague WG, Wenzel SE, Busse WW. Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med. 2012 Feb 15; 185(4):356-62. PMID: 22095547.
    Citations: 62     Fields:    Translation:Humans
  118. Li X, Ampleford EJ, Howard TD, Moore WC, Li H, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients. J Allergy Clin Immunol. 2012 Feb; 129(2):575-8, 578.e1-9. PMID: 22070912.
    Citations: 7     Fields:    Translation:Humans
  119. Wu R, Tong C, Wang Z, Mauger D, Tantisira K, Szefler SJ, Chinchilli VM, Israel E. A conceptual framework for pharmacodynamic genome-wide association studies in pharmacogenomics. Drug Discov Today. 2011 Oct; 16(19-20):884-90. PMID: 21920452.
    Citations: 4     Fields:    Translation:Humans
  120. Wechsler ME, Castro M, Lehman E, Chinchilli VM, Sutherland ER, Denlinger L, Lazarus SC, Peters SP, Israel E. Impact of race on asthma treatment failures in the asthma clinical research network. Am J Respir Crit Care Med. 2011 Dec 01; 184(11):1247-53. PMID: 21885625.
    Citations: 18     Fields:    Translation:Humans
  121. Kazani S, Israel E. Update in asthma 2010. Am J Respir Crit Care Med. 2011 Aug 01; 184(3):291-6. PMID: 21804120.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  122. Wechsler ME, Kelley JM, Boyd IO, Dutile S, Marigowda G, Kirsch I, Israel E, Kaptchuk TJ. Active albuterol or placebo, sham acupuncture, or no intervention in asthma. N Engl J Med. 2011 Jul 14; 365(2):119-26. PMID: 21751905.
    Citations: 66     Fields:    Translation:Humans
  123. Tun-Kyi A, Finn G, Greenwood A, Nowak M, Lee TH, Asara JM, Tsokos GC, Fitzgerald K, Israel E, Li X, Exley M, Nicholson LK, Lu KP. Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity. Nat Immunol. 2011 Jul 10; 12(8):733-41. PMID: 21743479.
    Citations: 30     Fields:    Translation:AnimalsCells
  124. Holguin F, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Moore WC, Peters SP, Yonas M, Teague WG, Wenzel SE. Obesity and asthma: an association modified by age of asthma onset. J Allergy Clin Immunol. 2011 Jun; 127(6):1486-93.e2. PMID: 21624618.
    Citations: 63     Fields:    Translation:Humans
  125. Kazani S, Israel E. Treatment with beta blockers in people with COPD. BMJ. 2011 May 10; 342:d2655. PMID: 21558358.
    Citations: 2     Fields:    Translation:Humans
  126. Comhair SA, Gaston BM, Ricci KS, Hammel J, Dweik RA, Teague WG, Meyers D, Ampleford EJ, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Israel E, Jarjour WN, Moore W, Peters SP, Wenzel S, Hazen SL, Erzurum SC. Detrimental effects of environmental tobacco smoke in relation to asthma severity. PLoS One. 2011 May 04; 6(5):e18574. PMID: 21572527.
    Citations: 16     Fields:    Translation:HumansPHPublic Health
  127. Birben E, Sackesen C, Kazani S, Tincer G, Karaaslan C, Durgunsu B, Gürsel I, Wechsler ME, Israel E, Kalayci O. The effects of an insertion in the 5'UTR of the AMCase on gene expression and pulmonary functions. Respir Med. 2011 Aug; 105(8):1160-9. PMID: 21511453.
    Citations: 1     Fields:    Translation:Humans
  128. Moore WC, Evans MD, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Erzurum SC, Curran-Everett D, Dweik RA, Gaston B, Hew M, Israel E, Mayse ML, Pascual RM, Peters SP, Silveira L, Wenzel SE, Jarjour NN. Safety of investigative bronchoscopy in the Severe Asthma Research Program. J Allergy Clin Immunol. 2011 Aug; 128(2):328-336.e3. PMID: 21496892.
    Citations: 10     Fields:    Translation:Humans
  129. Li X, Howard TD, Moore WC, Ampleford EJ, Li H, Busse WW, Calhoun WJ, Castro M, Chung KF, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Peters SP, Hawkins GA, Bleecker ER, Meyers DA. Importance of hedgehog interacting protein and other lung function genes in asthma. J Allergy Clin Immunol. 2011 Jun; 127(6):1457-65. PMID: 21397937.
    Citations: 51     Fields:    Translation:Humans
  130. Kazani S, Sadeh J, Bunga S, Wechsler ME, Israel E. Cysteinyl leukotriene antagonism inhibits bronchoconstriction in response to hypertonic saline inhalation in asthma. Respir Med. 2011 May; 105(5):667-73. PMID: 21169002.
    Citations: 1     Fields:    Translation:Humans
  131. Kazani S, Israel E. Exhaled breath condensates in asthma: diagnostic and therapeutic implications. J Breath Res. 2010 Dec; 4(4):047001. PMID: 21383487.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  132. Gaffin JM, Israel E, Phipatanakul W. The effect of prophylactic palivizumab on recurrent wheezing in children with an atopic family history. J Allergy Clin Immunol. 2011 Jan; 127(1):292-3; author reply 293. PMID: 21093033.
    Citations:    Fields:    Translation:Humans
  133. Gamble C, Talbott E, Youk A, Holguin F, Pitt B, Silveira L, Bleecker E, Busse W, Calhoun W, Castro M, Chung KF, Erzurum S, Israel E, Wenzel S. Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program. J Allergy Clin Immunol. 2010 Dec; 126(6):1149-56.e1. PMID: 21051082.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  134. Liu L, Teague WG, Erzurum S, Fitzpatrick A, Mantri S, Dweik RA, Bleecker ER, Meyers D, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Israel E, Jarjour WN, Moore W, Peters SP, Wenzel S, Hunt JF, Gaston B. Determinants of exhaled breath condensate pH in a large population with asthma. Chest. 2011 Feb; 139(2):328-336. PMID: 20966042.
    Citations: 13     Fields:    Translation:Humans
  135. Sutherland ER, King TS, Icitovic N, Ameredes BT, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Chinchilli VM, Craig TJ, Denlinger L, DiMango EA, Fahy JV, Israel E, Jarjour N, Kraft M, Lazarus SC, Lemanske RF, Peters SP, Ramsdell J, Sorkness CA, Szefler SJ, Walter MJ, Wasserman SI, Wechsler ME, Chu HW, Martin RJ. A trial of clarithromycin for the treatment of suboptimally controlled asthma. J Allergy Clin Immunol. 2010 Oct; 126(4):747-53. PMID: 20920764.
    Citations: 35     Fields:    Translation:HumansCells
  136. Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger L, Engle LL, DiMango EA, Fahy JV, Israel E, Jarjour N, Kazani SD, Kraft M, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Chinchilli VM, Bleecker ER. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 2010 Oct 28; 363(18):1715-26. PMID: 20979471.
    Citations: 85     Fields:    Translation:Humans
  137. Balzar S, Fajt ML, Comhair SA, Erzurum SC, Bleecker E, Busse WW, Castro M, Gaston B, Israel E, Schwartz LB, Curran-Everett D, Moore CG, Wenzel SE. Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. Am J Respir Crit Care Med. 2011 Feb 01; 183(3):299-309. PMID: 20813890.
    Citations: 61     Fields:    Translation:HumansCells
  138. Price D, Martin RJ, Barnes N, Dorinsky P, Israel E, Roche N, Chisholm A, Hillyer EV, Kemp L, Lee AJ, von Ziegenweidt J, Colice G. Prescribing practices and asthma control with hydrofluoroalkane-beclomethasone and fluticasone: a real-world observational study. J Allergy Clin Immunol. 2010 Sep; 126(3):511-8.e1-10. PMID: 20692026.
    Citations: 21     Fields:    Translation:Humans
  139. Brasier AR, Victor S, Ju H, Busse WW, Curran-Everett D, Bleecker E, Castro M, Chung KF, Gaston B, Israel E, Wenzel SE, Erzurum SC, Jarjour NN, Calhoun WJ. Predicting intermediate phenotypes in asthma using bronchoalveolar lavage-derived cytokines. Clin Transl Sci. 2010 Aug; 3(4):147-57. PMID: 20718815.
    Citations: 22     Fields:    Translation:HumansCells
  140. Bhavsar PK, Levy BD, Hew MJ, Pfeffer MA, Kazani S, Israel E, Chung KF. Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma. Respir Res. 2010 Jun 07; 11:71. PMID: 20529300.
    Citations: 19     Fields:    Translation:HumansCells
  141. Kim S, Marigowda G, Oren E, Israel E, Wechsler ME. Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome. J Allergy Clin Immunol. 2010 Jun; 125(6):1336-43. PMID: 20513524.
    Citations: 53     Fields:    Translation:HumansCells
  142. Dweik RA, Sorkness RL, Wenzel S, Hammel J, Curran-Everett D, Comhair SA, Bleecker E, Busse W, Calhoun WJ, Castro M, Chung KF, Israel E, Jarjour N, Moore W, Peters S, Teague G, Gaston B, Erzurum SC. Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Am J Respir Crit Care Med. 2010 May 15; 181(10):1033-41. PMID: 20133930.
    Citations: 62     Fields:    Translation:Humans
  143. Kazani S, Wechsler ME, Israel E. The role of pharmacogenomics in improving the management of asthma. J Allergy Clin Immunol. 2010 Feb; 125(2):295-302; quiz 303-4. PMID: 20159237.
    Citations: 11     Fields:    Translation:Humans
  144. Kazani S, Israel E. Long-acting beta-agonists and inhaled corticosteroids: is the whole greater than the sum of its parts? J Allergy Clin Immunol. 2010 Feb; 125(2):357-8. PMID: 20159244.
    Citations: 2     Fields:    Translation:Humans
  145. Sheehan WJ, Rangsithienchai PA, Baxi SN, Gardynski A, Bharmanee A, Israel E, Phipatanakul W. Age-specific prevalence of outdoor and indoor aeroallergen sensitization in Boston. Clin Pediatr (Phila). 2010 Jun; 49(6):579-85. PMID: 20075031.
    Citations: 8     Fields:    Translation:HumansAnimalsPHPublic Health
  146. Wechsler ME, Kunselman SJ, Chinchilli VM, Bleecker E, Boushey HA, Calhoun WJ, Ameredes BT, Castro M, Craig TJ, Denlinger L, Fahy JV, Jarjour N, Kazani S, Kim S, Kraft M, Lazarus SC, Lemanske RF, Markezich A, Martin RJ, Permaul P, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Walter MJ, Wasserman SI, Israel E. Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet. 2009 Nov 21; 374(9703):1754-64. PMID: 19932356.
    Citations: 46     Fields:    Translation:Humans
  147. Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R, Castro M, Curran-Everett D, Fitzpatrick AM, Gaston B, Jarjour NN, Sorkness R, Calhoun WJ, Chung KF, Comhair SA, Dweik RA, Israel E, Peters SP, Busse WW, Erzurum SC, Bleecker ER. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010 Feb 15; 181(4):315-23. PMID: 19892860.
    Citations: 349     Fields:    Translation:Humans
  148. Castro M, Rubin AS, Laviolette M, Fiterman J, De Andrade Lima M, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Duhamel DR, McEvoy C, Barbers R, Ten Hacken NH, Wechsler ME, Holmes M, Phillips MJ, Erzurum S, Lunn W, Israel E, Jarjour N, Kraft M, Shargill NS, Quiring J, Berry SM, Cox G. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2010 Jan 15; 181(2):116-24. PMID: 19815809.
    Citations: 93     Fields:    Translation:Humans
  149. Matangkasombut P, Marigowda G, Ervine A, Idris L, Pichavant M, Kim HY, Yasumi T, Wilson SB, DeKruyff RH, Faul JL, Israel E, Akbari O, Umetsu DT. Natural killer T cells in the lungs of patients with asthma. J Allergy Clin Immunol. 2009 May; 123(5):1181-5. PMID: 19356791.
    Citations: 29     Fields:    Translation:HumansCells
  150. Wedes SH, Khatri SB, Zhang R, Wu W, Comhair SA, Wenzel S, Teague WG, Israel E, Erzurum SC, Hazen SL. Noninvasive markers of airway inflammation in asthma. Clin Transl Sci. 2009 Apr; 2(2):112-7. PMID: 20234847.
    Citations: 24     Fields:    Translation:Humans
  151. Sheehan WJ, Rangsithienchai PA, Muilenberg ML, Rogers CA, Lane JP, Ghaemghami J, Rivard DV, Otsu K, Hoffman EB, Israel E, Gold DR, Phipatanakul W. Mouse allergens in urban elementary schools and homes of children with asthma. Ann Allergy Asthma Immunol. 2009 Feb; 102(2):125-30. PMID: 19230463.
    Citations: 29     Fields:    Translation:HumansAnimals
  152. Busse WW, Israel E, Nelson HS, Baker JW, Charous BL, Young DY, Vexler V, Shames RS. Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial. Am J Respir Crit Care Med. 2008 Nov 15; 178(10):1002-8. PMID: 18787222.
    Citations: 32     Fields:    Translation:HumansCells
  153. Lara A, Khatri SB, Wang Z, Comhair SA, Xu W, Dweik RA, Bodine M, Levison BS, Hammel J, Bleecker E, Busse W, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Gaston B, Israel E, Jarjour N, Moore W, Peters SP, Teague WG, Wenzel S, Hazen SL, Erzurum SC. Alterations of the arginine metabolome in asthma. Am J Respir Crit Care Med. 2008 Oct 01; 178(7):673-81. PMID: 18635886.
    Citations: 33     Fields:    Translation:Humans
  154. Chen H, Johnson CA, Haselkorn T, Lee JH, Israel E. Subspecialty differences in asthma characteristics and management. Mayo Clin Proc. 2008 Jul; 83(7):786-93. PMID: 18613995.
    Citations: 5     Fields:    Translation:Humans
  155. Planagumà A, Kazani S, Marigowda G, Haworth O, Mariani TJ, Israel E, Bleecker ER, Curran-Everett D, Erzurum SC, Calhoun WJ, Castro M, Chung KF, Gaston B, Jarjour NN, Busse WW, Wenzel SE, Levy BD. Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. Am J Respir Crit Care Med. 2008 Sep 15; 178(6):574-82. PMID: 18583575.
    Citations: 61     Fields:    Translation:Humans
  156. Sorkness RL, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Erzurum SC, Gaston BM, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Wenzel SE. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol (1985). 2008 Feb; 104(2):394-403. PMID: 17991792.
    Citations: 68     Fields:    Translation:HumansCTClinical Trials
  157. Yawn BP, Enright PL, Lemanske RF, Israel E, Pace W, Wollan P, Boushey H. Spirometry can be done in family physicians' offices and alters clinical decisions in management of asthma and COPD. Chest. 2007 Oct; 132(4):1162-8. PMID: 17550939.
    Citations: 28     Fields:    Translation:Humans
  158. Kraft M, Israel E, O'Connor GT. Clinical Decisions. Treatment of mild persistent asthma. N Engl J Med. 2007 May 17; 356(20):2096-100. PMID: 17507711.
    Citations: 1     Fields:    Translation:Humans
  159. Wechsler ME, Israel E. beta-adrenergic receptor genotype and response to salmeterol. J Allergy Clin Immunol. 2007 Jul; 120(1):218-9; author reply 219-20. PMID: 17399776.
    Citations: 3     Fields:    Translation:Humans
  160. Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, Bacharier L, Calhoun WJ, Castro M, Chung KF, Clark MP, Dweik RA, Fitzpatrick AM, Gaston B, Hew M, Hussain I, Jarjour NN, Israel E, Levy BD, Murphy JR, Peters SP, Teague WG, Meyers DA, Busse WW, Wenzel SE. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 2007 Feb; 119(2):405-13. PMID: 17291857.
    Citations: 228     Fields:    Translation:Humans
  161. Lazarus SC, Chinchilli VM, Rollings NJ, Boushey HA, Cherniack R, Craig TJ, Deykin A, DiMango E, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lemanske RF, Leone FT, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Wechsler ME, Fahy JV. Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med. 2007 Apr 15; 175(8):783-90. PMID: 17204725.
    Citations: 73     Fields:    Translation:Humans
  162. Levy BD, Kohli P, Gotlinger K, Haworth O, Hong S, Kazani S, Israel E, Haley KJ, Serhan CN. Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. J Immunol. 2007 Jan 01; 178(1):496-502. PMID: 17182589.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  163. Martin RJ, Szefler SJ, King TS, Kraft M, Boushey HA, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fahy JV, Israel E, Lazarus SC, Lemanske RF, Leone FT, Pesola GR, Peters SP, Sorkness CA, Szwejbka LA, Wechsler ME. The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial. J Allergy Clin Immunol. 2007 Jan; 119(1):73-80. PMID: 17208587.
    Citations: 52     Fields:    Translation:Humans
  164. Wenzel SE, Balzar S, Ampleford E, Hawkins GA, Busse WW, Calhoun WJ, Castro M, Chung KF, Erzurum S, Gaston B, Israel E, Teague WG, Curran-Everett D, Meyers DA, Bleecker ER. IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression. Am J Respir Crit Care Med. 2007 Mar 15; 175(6):570-6. PMID: 17170387.
    Citations: 28     Fields:    Translation:HumansCells
  165. Deykin A, Wechsler ME, Boushey HA, Chinchilli VM, Kunselman SJ, Craig TJ, DiMango E, Fahy JV, Kraft M, Leone F, Lazarus SC, Lemanske RF, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Israel E. Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma. Am J Respir Crit Care Med. 2007 Feb 01; 175(3):228-34. PMID: 16973987.
    Citations: 15     Fields:    Translation:Humans
  166. Wechsler ME, Lehman E, Lazarus SC, Lemanske RF, Boushey HA, Deykin A, Fahy JV, Sorkness CA, Chinchilli VM, Craig TJ, DiMango E, Kraft M, Leone F, Martin RJ, Peters SP, Szefler SJ, Liu W, Israel E. beta-Adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med. 2006 Mar 01; 173(5):519-26. PMID: 16322642.
    Citations: 60     Fields:    Translation:Humans
  167. Gibbons FK, Israel E, Deykin A, Schaub B, He HZ, Perkins DL, Finn PW. The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion. J Clin Immunol. 2005 Sep; 25(5):437-44. PMID: 16160912.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  168. Khush KK, Randhawa R, Israel E. A full house: complications from an uncorrected patent ductus arteriosus. Curr Cardiol Rep. 2005 Jul; 7(4):310-3. PMID: 15987630.
    Citations:    Fields:    Translation:Humans
  169. Levy BD, Bonnans C, Silverman ES, Palmer LJ, Marigowda G, Israel E. Diminished lipoxin biosynthesis in severe asthma. Am J Respir Crit Care Med. 2005 Oct 01; 172(7):824-30. PMID: 15961693.
    Citations: 76     Fields:    Translation:Humans
  170. Boushey HA, Sorkness CA, King TS, Sullivan SD, Fahy JV, Lazarus SC, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fagan JK, Fish JE, Ford JG, Kraft M, Lemanske RF, Leone FT, Martin RJ, Mauger EA, Pesola GR, Peters SP, Rollings NJ, Szefler SJ, Wechsler ME, Israel E. Daily versus as-needed corticosteroids for mild persistent asthma. N Engl J Med. 2005 Apr 14; 352(15):1519-28. PMID: 15829533.
    Citations: 75     Fields:    Translation:HumansCTClinical Trials
  171. Israel E. Genetics and the variability of treatment response in asthma. J Allergy Clin Immunol. 2005 Apr; 115(4 Suppl):S532-8. PMID: 15806036.
    Citations: 5     Fields:    Translation:Humans
  172. Deykin A, Lazarus SC, Fahy JV, Wechsler ME, Boushey HA, Chinchilli VM, Craig TJ, Dimango E, Kraft M, Leone F, Lemanske RF, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Israel E. Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. J Allergy Clin Immunol. 2005 Apr; 115(4):720-7. PMID: 15805990.
    Citations: 28     Fields:    Translation:HumansCellsCTClinical Trials
  173. Wechsler ME, Israel E. How pharmacogenomics will play a role in the management of asthma. Am J Respir Crit Care Med. 2005 Jul 01; 172(1):12-8. PMID: 15778484.
    Citations: 5     Fields:    Translation:Humans
  174. Bowton DL, Dmitrienko AA, Israel E, Zeiher BG, Sides GD. Impact of a soluble phospholipase A2 inhibitor on inhaled allergen challenge in subjects with asthma. J Asthma. 2005 Feb; 42(1):65-71. PMID: 15801331.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  175. Lilly CM, Tateno H, Oguma T, Israel E, Sonna LA. Effects of allergen challenge on airway epithelial cell gene expression. Am J Respir Crit Care Med. 2005 Mar 15; 171(6):579-86. PMID: 15618462.
    Citations: 23     Fields:    Translation:HumansCells
  176. Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Liggett SB, Martin RJ, Mitra N, Peters SP, Silverman E, Sorkness CA, Szefler SJ, Wechsler ME, Weiss ST, Drazen JM. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet. 2004 Oct 23-29; 364(9444):1505-12. PMID: 15500895.
    Citations: 132     Fields:    Translation:HumansCTClinical Trials
  177. Tantisira KG, Lake S, Silverman ES, Palmer LJ, Lazarus R, Silverman EK, Liggett SB, Gelfand EW, Rosenwasser LJ, Richter B, Israel E, Wechsler M, Gabriel S, Altshuler D, Lander E, Drazen J, Weiss ST. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet. 2004 Jul 01; 13(13):1353-9. PMID: 15128701.
    Citations: 85     Fields:    Translation:Humans
  178. Black LD, Henderson AC, Atileh H, Israel E, Ingenito EP, Lutchen KR. Relating maximum airway dilation and subsequent reconstriction to reactivity in human lungs. J Appl Physiol (1985). 2004 May; 96(5):1808-14. PMID: 14766781.
    Citations: 12     Fields:    Translation:Humans
  179. Sadeh J, Israel E. Airway narrowing in athletes: a different kettle of fish? Am J Respir Crit Care Med. 2003 Nov 15; 168(10):1146-7. PMID: 14607821.
    Citations: 3     Fields:    Translation:Humans
  180. Richy F, Bousquet J, Ehrlich GE, Meunier PJ, Israel E, Morii H, Devogelaer JP, Peel N, Haim M, Bruyere O, Reginster JY. Inhaled corticosteroids effects on bone in asthmatic and COPD patients: a quantitative systematic review. Osteoporos Int. 2003 May; 14(3):179-90. PMID: 12730758.
    Citations: 21     Fields:    Translation:Humans
  181. Kalayci O, Wechsler M, Galper B, Hong C, Israel E, Drazen JM, Lilly CM. LTC4 production by eosinophils in asthmatic subjects with alternative forms of ALOX-5 core promoter. Adv Exp Med Biol. 2003; 525:11-4. PMID: 12751728.
    Citations:    Fields:    Translation:HumansCells
  182. Israel E, Chervinsky PS, Friedman B, Van Bavel J, Skalky CS, Ghannam AF, Bird SR, Edelman JM. Effects of montelukast and beclomethasone on airway function and asthma control. J Allergy Clin Immunol. 2002 Dec; 110(6):847-54. PMID: 12464949.
    Citations: 23     Fields:    Translation:HumansCTClinical Trials
  183. Wechsler ME, Israel E. Pharmacogenetics of treatment with leukotriene modifiers. Curr Opin Allergy Clin Immunol. 2002 Oct; 2(5):395-401. PMID: 12582322.
    Citations:    Fields:    Translation:Humans
  184. Wechsler ME, Israel E. The genetics of asthma. Semin Respir Crit Care Med. 2002 Aug; 23(4):331-8. PMID: 16088626.
    Citations: 2     Fields:    
  185. Deykin A, Massaro AF, Drazen JM, Israel E. Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rate. Am J Respir Crit Care Med. 2002 Jun 15; 165(12):1597-601. PMID: 12070059.
    Citations: 25     Fields:    Translation:Humans
  186. Martin RJ, Szefler SJ, Chinchilli VM, Kraft M, Dolovich M, Boushey HA, Cherniack RM, Craig TJ, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kunselman SJ, Lazarus SC, Lemanske RF, Peters SP, Sorkness CA. Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Respir Crit Care Med. 2002 May 15; 165(10):1377-83. PMID: 12016099.
    Citations: 38     Fields:    Translation:HumansCTClinical Trials
  187. Szefler SJ, Martin RJ, King TS, Boushey HA, Cherniack RM, Chinchilli VM, Craig TJ, Dolovich M, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lazarus SC, Lemanske RF, Mauger E, Peters SP, Sorkness CA. Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol. 2002 Mar; 109(3):410-8. PMID: 11897984.
    Citations: 115     Fields:    Translation:HumansCTClinical Trials
  188. Israel E, Banerjee TR, Fitzmaurice GM, Kotlov TV, LaHive K, LeBoff MS. Effects of inhaled glucocorticoids on bone density in premenopausal women. N Engl J Med. 2001 Sep 27; 345(13):941-7. PMID: 11575285.
    Citations: 45     Fields:    Translation:Humans
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