Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Elliot Israel, M.D.

Title
Institution
Department
Address
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL146002 (LEVY, BRUCE D) Sep 23, 2019 - Jun 30, 2024
    NIH/NHLBI
    Immunometabolic phenotypes in adult severe asthma and disease progression
    Role: Co-Principal Investigator
  2. U01HL146002 (LEVY, BRUCE D) Sep 23, 2019 - Jun 30, 2024
    NIH
    Immunometabolic phenotypes in adult severe asthma and disease progression
    Role: Co-Principal Investigator
  3. UG1HL139124 (ISRAEL, ELLIOT) Sep 23, 2017 - Jun 30, 2023
    NIH
    PATINA - Precision Administration of Treatment in Neutrophilic severe Asthma
    Role: Principal Investigator
  4. U10HL109172 (ISRAEL, ELLIOT) Aug 9, 2011 - May 31, 2019
    NIH
    AMSA: ALXR/FBR Mediated Signaling in Severe Asthma
    Role: Principal Investigator
  5. U19AI095219 (BOYCE, JOSHUA A) Jul 15, 2011 - Apr 30, 2026
    NIH
    Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Panganiban RAM, Yang Z, Sun M, Park CY, Kasahara DI, Schaible N, Krishnan R, Kho AT, Israel E, Hershenson MB, Weiss ST, Himes BE, Fredberg JJ, Tantisira KG, Shore SA, Lu Q. Antagonizing cholecystokinin A receptor in the lung attenuates obesity-induced airway hyperresponsiveness. Nat Commun. 2023 Jan 04; 14(1):47. PMID: 36599824; PMCID: PMC9813361.
    Citations:    Fields:    Translation:Animals
  2. Yawn BP, Ericson B, Cui J, Israel E, Maher N, Pace W, Fuhlbrigge A. Comparing asthma control assessment using the Asthma Control Test and the Asthma APGAR in African American/Black and Hispanic/Latinx populations. J Asthma. 2023 Jan 03; 1-13. PMID: 36594270.
    Citations:    Fields:    
  3. Peters MC, Schiebler ML, Cardet JC, Johansson MW, Sorkness R, DeBoer MD, Bleecker ER, Meyers DA, Castro M, Sumino K, Erzurum SC, Tattersall MC, Zein JG, Hastie AT, Moore W, Levy BD, Israel E, Phillips BR, Mauger DT, Wenzel SE, Fajt ML, Koliwad SK, Denlinger LC, Woodruff PG, Jarjour NN, Fahy JV. The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma. Am J Respir Crit Care Med. 2022 11 01; 206(9):1096-1106. PMID: 35687105; PMCID: PMC9704842.
    Citations:    Fields:    
  4. Tattersall MC, Lee KE, Tsuchiya N, Osman F, Korcarz CE, Hansen KM, Peters MC, Fahy JV, Longhurst CA, Dunican E, Wentzel SE, Leader JK, Israel E, Levy BD, Castro M, Erzurum SC, Lempel J, Moore W, Bleecker E, Phillips BR, Mauger DT, Hoffman EA, Fain SB, Reeder SB, Sorkness RL, Jarjour NN, Denlinger LC, Schiebler ML. Skeletal Muscle Adiposity and Lung Function Trajectory in the Severe Asthma Research Program (SARP). Am J Respir Crit Care Med. 2022 Oct 04. PMID: 36194556.
    Citations:    Fields:    
  5. Wang Z, Xu W, Comhair SAA, Fu X, Shao Z, Bearden R, Zein JG, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Mauger DT, Gaston B, Hazen SL, Erzurum SC. Urinary total conjugated 3-bromotyrosine, asthma severity, and exacerbation risk. Am J Physiol Lung Cell Mol Physiol. 2022 11 01; 323(5):L548-L557. PMID: 36126269; PMCID: PMC9602918.
    Citations:    Fields:    Translation:HumansCells
  6. Li X, Guerra S, Ledford JG, Kraft M, Li H, Hastie AT, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Meyers DA, Bleecker ER. Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity. Am J Respir Crit Care Med. 2022 Sep 06. PMID: 36066606.
    Citations: 1     Fields:    
  7. Ramsey NB, Apter AJ, Israel E, Louisias MM, Noroski LM, Nyenhuis SM, Ogbogu PU, Perry TT, Wang J, Davis CM. Reply to "How to deconstruct 'race' and spirometry". J Allergy Clin Immunol Pract. 2022 09; 10(9):2489-2491. PMID: 36087950.
    Citations:    Fields:    Translation:Humans
  8. Gaffin JM, Petty CR, Sorkness RL, Denlinger LC, Phillips BR, Ly NP, Gaston B, Ross K, Fitzpatrick A, Bacharier LB, DeBoer MD, Teague WG, Wenzel SE, Ramratnam S, Israel E, Mauger DT, Phipatanakul W. Determinants of lung function across childhood in the Severe Asthma Research Program (SARP) 3. J Allergy Clin Immunol. 2023 Jan; 151(1):138-146.e9. PMID: 36041656; PMCID: PMC9825637.
    Citations:    Fields:    Translation:Humans
  9. Cardet JC, Shenoy K, Baydur A, Carroll JK, Celedón JC, Cui J, Dara P, Ericson B, Forth VE, Fagan M, Fuhlbrigge AL, Gupta R, Hart MK, Hernandez ML, Hernandez PA, Kruse J, Maher NE, Manning BK, Pinto-Plata VM, Robles J, Rodriguez-Louis J, Shields JB, Telon Sosa BS, Wechsler ME, Israel E. Caribbean Latinx with moderate-severe asthma bear greater asthma morbidity than other Latinx. J Allergy Clin Immunol. 2022 11; 150(5):1106-1113.e10. PMID: 35779669; PMCID: PMC9643605.
    Citations:    Fields:    
  10. Davidescu L, Ursol G, Korzh O, Deshmukh V, Kuryk L, Nortje MM, Godlevska O, Devouassoux G, Khodosh E, Israel E, Moussy A, Mansfield CD, Hermine O, Chanez P. Efficacy and Safety of Masitinib in Corticosteroid-Dependent Severe Asthma: A Randomized Placebo-Controlled Trial. J Asthma Allergy. 2022; 15:737-747. PMID: 35698580; PMCID: PMC9188333.
    Citations:    
  11. Cardet JC, Chang KL, Rooks BJ, Carroll JK, Celedón JC, Coyne-Beasley T, Cui J, Ericson B, Forth VE, Fagan M, Fuhlbrigge AL, Hernandez PA, Kruse J, Louisias M, Maher NE, Manning B, Pace WD, Phipatanakul W, Rodriguez-Louis J, Shields JB, Israel E, Wisnivesky JP. Socioeconomic status associates with worse asthma morbidity among Black and Latinx adults. J Allergy Clin Immunol. 2022 10; 150(4):841-849.e4. PMID: 35597370.
    Citations:    Fields:    
  12. Papi A, Chipps BE, Beasley R, Panettieri RA, Israel E, Cooper M, Dunsire L, Jeynes-Ellis A, Johnsson E, Rees R, Cappelletti C, Albers FC. Albuterol-Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma. N Engl J Med. 2022 06 02; 386(22):2071-2083. PMID: 35569035.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  13. Izquierdo ME, Marion CR, Moore WC, Raraigh KS, Taylor-Cousar JL, Cutting GR, Ampleford E, Hawkins GA, Zein J, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Mauger D, Levy BD, Wenzel SE, Woodruff P, Bleecker ER, Meyers DA, Ortega VE. DNA sequencing analysis of cystic fibrosis transmembrane conductance regulator gene identifies cystic fibrosis-associated variants in the Severe Asthma Research Program. Pediatr Pulmonol. 2022 07; 57(7):1782-1788. PMID: 35451201; PMCID: PMC9443928.
    Citations: 1     Fields:    Translation:Humans
  14. Tang M, Elicker BM, Henry T, Gierada DS, Schiebler ML, Huang BK, Peters MC, Castro M, Hoffman EA, Fain SB, Ash SY, Choi J, Hall C, Phillips BR, Mauger DT, Denlinger LC, Jarjour NN, Israel E, Phipatanakul W, Levy BD, Wenzel SE, Bleecker ER, Woodruff PG, Fahy JV, Dunican EM. Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time. Am J Respir Crit Care Med. 2022 05 01; 205(9):1036-1045. PMID: 35104436; PMCID: PMC9851493.
    Citations:    Fields:    Translation:Humans
  15. Trivedi AP, Hall C, Goss CW, Lew D, Krings JG, McGregor MC, Samant M, Sieren JP, Li H, Schechtman KB, Schirm J, McEleney S, Peterson S, Moore WC, Bleecker ER, Meyers DA, Israel E, Washko GR, Levy BD, Leader JK, Wenzel SE, Fahy JV, Schiebler ML, Fain SB, Jarjour NN, Mauger DT, Reinhardt JM, Newell JD, Hoffman EA, Castro M, Sheshadri A. Quantitative CT Characteristics of Cluster Phenotypes in the Severe Asthma Research Program Cohorts. Radiology. 2022 08; 304(2):450-459. PMID: 35471111; PMCID: PMC9340243.
    Citations:    Fields:    Translation:Humans
  16. Cardet JC, Kim D, Bleecker ER, Casale TB, Israel E, Mauger D, Meyers DA, Ampleford E, Hawkins GA, Tu Y, Liggett SB, Ortega VE. Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma. J Allergy Clin Immunol. 2022 09; 150(3):721-726.e1. PMID: 35398411; PMCID: PMC9642856.
    Citations:    Fields:    
  17. Krishnan JA, Lazarus SC, Blake KV, Sorkness CA, Covar R, Dyer AM, Lang JE, Lugogo NL, Mauger DT, Wechsler ME, Wenzel SE, Cardet JC, Castro M, Israel E, Phipatanakul W, King TS. Biomarkers to Predict Response to Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists in Adolescents and Adults with Mild Persistent Asthma. Ann Am Thorac Soc. 2022 03; 19(3):372-380. PMID: 34793687; PMCID: PMC8937224.
    Citations:    Fields:    Translation:Humans
  18. Israel E, Cardet JC, Carroll JK, Fuhlbrigge AL, She L, Rockhold FW, Maher NE, Fagan M, Forth VE, Yawn BP, Arias Hernandez P, Kruse JM, Manning BK, Rodriguez-Louis J, Shields JB, Ericson B, Colon-Moya AD, Madison S, Coyne-Beasley T, Hammer GM, Kaplan BM, Rand CS, Robles J, Thompson O, Wechsler ME, Wisnivesky JP, McKee MD, Jariwala SP, Jerschow E, Busse PJ, Kaelber DC, Nazario S, Hernandez ML, Apter AJ, Chang KL, Pinto-Plata V, Stranges PM, Hurley LP, Trevor J, Casale TB, Chupp G, Riley IL, Shenoy K, Pasarica M, Calderon-Candelario RA, Tapp H, Baydur A, Pace WD. Reliever-Triggered Inhaled Glucocorticoid in Black and Latinx Adults with Asthma. N Engl J Med. 2022 04 21; 386(16):1505-1518. PMID: 35213105.
    Citations:    Fields:    Translation:Humans
  19. Ramsey NB, Apter AJ, Israel E, Louisias M, Noroski LM, Nyenhuis SM, Ogbogu PU, Perry TT, Wang J, Davis CM. Deconstructing the Way We Use Pulmonary Function Test Race-Based Adjustments. J Allergy Clin Immunol Pract. 2022 04; 10(4):972-978. PMID: 35184982.
    Citations:    Fields:    Translation:Humans
  20. Guilbert TW, Israel E. Key Issues in Pediatric and Adult Severe Asthma: Staying Grounded as Biologics Take Us to New Heights. J Allergy Clin Immunol Pract. 2022 02; 10(2):420-421. PMID: 35144773.
    Citations:    Fields:    Translation:Humans
  21. Carroll JK, Arias Hernandez P, Brooks-Greisen A, Carlos Cardet J, Cui J, Ericson B, Fagan M, Fajt ML, Forth VE, Fuhlbrigge AL, Lorenzi M, Rodriguez-Louis J, Maher NE, Manning BK, Pace WD, Shields JB, Israel E. Socioeconomic impact of COVID-19 and willingness to be vaccinated in African American/Black and Hispanic/Latinx adults. J Natl Med Assoc. 2022 Apr; 114(2):182-192. PMID: 35090746; PMCID: PMC8789400.
    Citations:    Fields:    Translation:HumansPHPublic Health
  22. Israel E, Canonica GW, Brusselle G, Yang S, Howarth PH, Martin AL, Koufopoulou M, Smith SG, Alfonso-Cristancho R. Real-life effectiveness of mepolizumab in severe asthma: a systematic literature review. J Asthma. 2022 Nov; 59(11):2201-2217. PMID: 34951336.
    Citations:    Fields:    
  23. Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, Crotty Alexander L, Bamdad J, Cardet JC, Comhair SAA, Covar RA, DiMango EA, Erwin K, Erzurum SC, Fahy JV, Gaffin JM, Gaston B, Gerald LB, Hoffman EA, Holguin F, Jackson DJ, James J, Jarjour NN, Kenyon NJ, Khatri S, Kirwan JP, Kraft M, Krishnan JA, Liu AH, Liu MC, Marquis MA, Martinez F, Mey J, Moore WC, Moy JN, Ortega VE, Peden DB, Pennington E, Peters MC, Ross K, Sanchez M, Smith LJ, Sorkness RL, Wechsler ME, Wenzel SE, White SR, Zein J, Zeki AA, Noel P. The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions. J Allergy Clin Immunol. 2022 02; 149(2):488-516.e9. PMID: 34848210; PMCID: PMC8821377.
    Citations:    Fields:    Translation:Humans
  24. Ortega VE, Daya M, Szefler SJ, Bleecker ER, Chinchilli VM, Phipatanakul W, Mauger D, Martinez FD, Herrera-Luis E, Pino-Yanes M, Hawkins GA, Ampleford EJ, Kunselman SJ, Cox C, Bacharier LB, Cabana MD, Cardet JC, Castro M, Denlinger LC, Eng C, Fitzpatrick AM, Holguin F, Hu D, Jackson DJ, Jarjour N, Kraft M, Krishnan JA, Lazarus SC, Lemanske RF, Lima JJ, Lugogo N, Mak A, Moore WC, Naureckas ET, Peters SP, Pongracic JA, Sajuthi SP, Seibold MA, Smith LJ, Solway J, Sorkness CA, Wenzel S, White SR, Burchard EG, Barnes K, Meyers DA, Israel E, Wechsler ME. Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma. Lancet Child Adolesc Health. 2021 12; 5(12):862-872. PMID: 34762840; PMCID: PMC8787857.
    Citations: 1     Fields:    Translation:Humans
  25. Wechsler ME, Ruddy MK, Pavord ID, Israel E, Rabe KF, Ford LB, Maspero JF, Abdulai RM, Hu CC, Martincova R, Jessel A, Nivens MC, Amin N, Weinreich DM, Yancopoulos GD, Goulaouic H. Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma. N Engl J Med. 2021 10 28; 385(18):1656-1668. PMID: 34706171.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  26. Apter A, Carroll JK, Cardet JC, Cohen R, Colon-Moya AD, Ericson B, Forth VE, Gaefke C, Maher N, Morales-Cosme W, Rodriguez-Louis J, Tulchinsky A, Israel E. Nebulizer Use by Black and Latinx Adults with Moderate to Severe Asthma. J Allergy Clin Immunol Pract. 2022 02; 10(2):517-524.e2. PMID: 34673286.
    Citations:    Fields:    Translation:Humans
  27. Scheer FAJL, Hilton MF, Evoniuk HL, Shiels SA, Malhotra A, Sugarbaker R, Ayers RT, Israel E, Massaro AF, Shea SA. The endogenous circadian system worsens asthma at night independent of sleep and other daily behavioral or environmental cycles. Proc Natl Acad Sci U S A. 2021 09 14; 118(37). PMID: 34493686; PMCID: PMC8449316.
    Citations: 5     Fields:    Translation:Humans
  28. Phipatanakul W, Koutrakis P, Coull BA, Petty CR, Gaffin JM, Sheehan WJ, Lai PS, Bartnikas LM, Kang CM, Wolfson JM, Samnaliev M, Cunningham A, Baxi SN, Permaul P, Hauptman M, Trivedi M, Louisias M, Liang L, Thorne PS, Metwali N, Adamkiewicz G, Israel E, Baccarelli AA, Gold DR. Effect of School Integrated Pest Management or Classroom Air Filter Purifiers on Asthma Symptoms in Students With Active Asthma: A Randomized Clinical Trial. JAMA. 2021 09 07; 326(9):839-850. PMID: 34547084; PMCID: PMC8424475.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  29. Zein JG, McManus JM, Sharifi N, Erzurum SC, Marozkina N, Lahm T, Giddings O, Davis MD, DeBoer MD, Comhair SA, Bazeley P, Kim HJ, Busse W, Calhoun W, Castro M, Chung KF, Fahy JV, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Ortega VE, Peters M, Bleecker ER, Meyers DA, Zhao Y, Wenzel SE, Gaston B. Benefits of Airway Androgen Receptor Expression in Human Asthma. Am J Respir Crit Care Med. 2021 08 01; 204(3):285-293. PMID: 33779531; PMCID: PMC8513596.
    Citations: 6     Fields:    Translation:Humans
  30. Gern JE, Israel E. Mechanisms and Treatment of the Diverse Presentations of Acute Wheezing and Asthma. J Allergy Clin Immunol Pract. 2021 07; 9(7):2635-2637. PMID: 34246436.
    Citations: 1     Fields:    Translation:Humans
  31. Menzies-Gow A, Corren J, Bourdin A, Chupp G, Israel E, Wechsler ME, Brightling CE, Griffiths JM, Hellqvist Å, Bowen K, Kaur P, Almqvist G, Ponnarambil S, Colice G. Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma. N Engl J Med. 2021 05 13; 384(19):1800-1809. PMID: 33979488.
    Citations: 50     Fields:    Translation:HumansCTClinical Trials
  32. Salciccioli JD, She L, Tulchinsky A, Rockhold F, Cardet JC, Israel E. Effect of COVID-19 on asthma exacerbation. J Allergy Clin Immunol Pract. 2021 Jul; 9(7):2896-2899.e1. PMID: 33940216.
    Citations: 8     Fields:    Translation:HumansCells
  33. Kasela S, Ortega VE, Martorella M, Garudadri S, Nguyen J, Ampleford E, Pasanen A, Nerella S, Buschur KL, Barjaktarevic IZ, Barr RG, Bleecker ER, Bowler RP, Comellas AP, Cooper CB, Couper DJ, Criner GJ, Curtis JL, Han MK, Hansel NN, Hoffman EA, Kaner RJ, Krishnan JA, Martinez FJ, McDonald MN, Meyers DA, Paine R, Peters SP, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Levy BD, Li X, Moore WC, Wenzel SE, Zein J, Langelier C, Woodruff PG, Lappalainen T, Christenson SA. Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium. Genome Med. 2021 04 21; 13(1):66. PMID: 33883027; PMCID: PMC8059115.
    Citations: 5     Fields:    Translation:HumansCells
  34. Kelsen SG, Agache IO, Soong W, Israel E, Chupp GL, Cheung DS, Theess W, Yang X, Staton TL, Choy DF, Fong A, Dash A, Dolton M, Pappu R, Brightling CE. Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial. J Allergy Clin Immunol. 2021 09; 148(3):790-798. PMID: 33872652.
    Citations: 17     Fields:    Translation:HumansCellsCTClinical Trials
  35. Hastie AT, Mauger DT, Denlinger LC, Coverstone A, Castro M, Erzurum S, Jarjour N, Levy BD, Meyers DA, Moore WC, Phillips BR, Wenzel SE, Fahy JV, Israel E, Bleecker ER. Mixed Sputum Granulocyte Longitudinal Impact on Lung Function in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2021 04 01; 203(7):882-892. PMID: 33545021; PMCID: PMC8017570.
    Citations: 8     Fields:    Translation:HumansCells
  36. Denlinger LC, Phillips BR, Sorkness RL, Bleecker ER, Castro M, DeBoer MD, Fitzpatrick AM, Hastie AT, Gaffin JM, Moore WC, Peters MC, Peters SP, Phipatanakul W, Cardet JC, Erzurum SC, Fahy JV, Fajt ML, Gaston B, Levy BD, Meyers DA, Ross K, Teague WG, Wenzel SE, Woodruff PG, Zein J, Jarjour NN, Mauger DT, Israel E. Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate-to-Severe Asthma. Am J Respir Crit Care Med. 2021 04 01; 203(7):841-852. PMID: 33290668; PMCID: PMC8017577.
    Citations: 2     Fields:    Translation:Humans
  37. Baek SH, Foer D, Cahill KN, Israel E, Maiorino E, Röhl A, Boyce JA, Weiss ST. Systems Approaches to Treatment Response to Imatinib in Severe Asthma: A Pilot Study. J Pers Med. 2021 Mar 25; 11(4). PMID: 33805900.
    Citations:    
  38. Permaul P, Peters MC, Petty CR, Cardet JC, Ly NP, Ramratnam SK, Ross K, Fitzpatrick A, Israel E, Bacharier LB, Phipatanakul W. The association of plasma IL-6 with measures of asthma morbidity in a moderate-severe pediatric cohort aged 6-18 years. J Allergy Clin Immunol Pract. 2021 07; 9(7):2916-2919.e2. PMID: 33771493; PMCID: PMC8277679.
    Citations: 2     Fields:    Translation:Humans
  39. Israel E, Denlinger LC, Bacharier LB, LaVange LM, Moore WC, Peters MC, Georas SN, Wright RJ, Mauger DT, Noel P, Akuthota P, Bach J, Bleecker ER, Cardet JC, Carr TF, Castro M, Cinelli A, Comhair SAA, Covar RA, Alexander LC, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Hoffman EA, Holguin F, Jackson DJ, Jain S, Jarjour NN, Ji Y, Kenyon NJ, Kosorok MR, Kraft M, Krishnan JA, Kumar R, Liu AH, Liu MC, Ly NP, Marquis MA, Martinez FD, Moy JN, O'Neal WK, Ortega VE, Peden DB, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Tulchinsky AF, Vijayanand P, Wechsler ME, Wenzel SE, White SR, Zeki AA, Ivanova A. PrecISE: Precision Medicine in Severe Asthma: An adaptive platform trial with biomarker ascertainment. J Allergy Clin Immunol. 2021 05; 147(5):1594-1601. PMID: 33667479; PMCID: PMC8113113.
    Citations: 6     Fields:    Translation:Humans
  40. Krings JG, Goss CW, Lew D, Samant M, McGregor MC, Boomer J, Bacharier LB, Sheshadri A, Hall C, Brownell J, Schechtman KB, Peterson S, McEleney S, Mauger DT, Fahy JV, Fain SB, Denlinger LC, Israel E, Washko G, Hoffman E, Wenzel SE, Castro M. Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3. J Allergy Clin Immunol. 2021 09; 148(3):752-762. PMID: 33577895; PMCID: PMC8349941.
    Citations: 1     Fields:    Translation:Humans
  41. Clougherty JE, Kinnee EJ, Cardet JC, Mauger D, Bacharier L, Beigelman A, Blake KV, Cabana MD, Castro M, Chmiel JF, Covar R, Fitzpatrick A, Gaffin JM, Gentile D, Israel E, Jackson DJ, Kraft M, Krishnan JA, Kumar HV, Lang JE, Lazarus SC, Lemanske RF, Lima J, Martinez FD, Morgan W, Moy J, Myers R, Naureckas ET, Ortega VE, Peters SP, Phipatanakul W, Pongracic JA, Ross K, Sheehan WJ, Smith LJ, Solway J, Sorkness CA, Wechsler ME, Wenzel S, White SR, Holguin F. Geography, generalisability, and susceptibility in clinical trials. Lancet Respir Med. 2021 04; 9(4):330-332. PMID: 33539731; PMCID: PMC8009610.
    Citations: 2     Fields:    Translation:Humans
  42. Israel E, Cardet JC, Carroll JK, Fuhlbrigge AL, Pace WD, Maher NE, She L, Rockhold FW, Fagan M, Forth VE, Hernandez PA, Manning BK, Rodriguez-Louis J, Shields JB, Coyne-Beasley T, Kaplan BM, Rand CS, Morales-Cosme W, Wechsler ME, Wisnivesky JP, White M, Yawn BP, McKee MD, Busse PJ, Kaelber DC, Nazario S, Hernandez ML, Apter AJ, Chang KL, Pinto-Plata V, Stranges PM, Hurley LP, Trevor J, Casale TB, Chupp G, Riley IL, Shenoy K, Pasarica M, Calderon-Candelario RA, Tapp H, Baydur A. A randomized, open-label, pragmatic study to assess reliever-triggered inhaled corticosteroid in African American/Black and Hispanic/Latinx adults with asthma: Design and methods of the PREPARE trial. Contemp Clin Trials. 2021 02; 101:106246. PMID: 33316456; PMCID: PMC8130188.
    Citations: 1     Fields:    Translation:Humans
  43. Israel E. Implementing the guidelines: What do you do when the rubber hits the road? J Allergy Clin Immunol. 2020 12; 146(6):1271-1274. PMID: 33280710.
    Citations: 1     Fields:    Translation:Humans
  44. Phipatanakul W, Mauger DT, Guilbert TW, Bacharier LB, Durrani S, Jackson DJ, Martinez FD, Fitzpatrick AM, Cunningham A, Kunselman S, Wheatley LM, Bauer C, Davis CM, Geng B, Kloepfer KM, Lapin C, Liu AH, Pongracic JA, Teach SJ, Chmiel J, Gaffin JM, Greenhawt M, Gupta MR, Lai PS, Lemanske RF, Morgan WJ, Sheehan WJ, Stokes J, Thorne PS, Oettgen HC, Israel E. Preventing asthma in high risk kids (PARK) with omalizumab: Design, rationale, methods, lessons learned and adaptation. Contemp Clin Trials. 2021 01; 100:106228. PMID: 33242697; PMCID: PMC7887056.
    Citations: 1     Fields:    Translation:Humans
  45. Neuman MD, Kappelman MD, Israel E, Ellenberg SS, Girman C, Robb J, Rabinowitz A, Trontell A. Real-world experiences with generating real-world evidence: Case Studies from PCORI's pragmatic clinical Studies program. Contemp Clin Trials. 2020 11; 98:106171. PMID: 33038503.
    Citations:    Fields:    Translation:Humans
  46. Austin CD, Gonzalez Edick M, Ferrando RE, Solon M, Baca M, Mesh K, Bradding P, Gauvreau GM, Sumino K, FitzGerald JM, Israel E, Bjermer L, Bourdin A, Arron JR, Choy DF, Olsson JK, Abreu F, Howard M, Wong K, Cai F, Peng K, Putnam WS, Holweg CTJ, Matthews JG, Kraft M, Woodruff PG. A randomized, placebo-controlled trial evaluating effects of lebrikizumab on airway eosinophilic inflammation and remodelling in uncontrolled asthma (CLAVIER). Clin Exp Allergy. 2020 12; 50(12):1342-1351. PMID: 32909660.
    Citations: 9     Fields:    Translation:HumansCellsCTClinical Trials
  47. Peters MC, Mauger D, Ross KR, Phillips B, Gaston B, Cardet JC, Israel E, Levy BD, Phipatanakul W, Jarjour NN, Castro M, Wenzel SE, Hastie A, Moore W, Bleecker E, Fahy JV, Denlinger LC. Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency. Am J Respir Crit Care Med. 2020 10 01; 202(7):973-982. PMID: 32479111; PMCID: PMC7528796.
    Citations: 35     Fields:    Translation:HumansCells
  48. Ivanova A, Israel E, LaVange LM, Peters MC, Denlinger LC, Moore WC, Bacharier LB, Marquis MA, Gotman NM, Kosorok MR, Tomlinson C, Mauger DT, Georas SN, Wright RJ, Noel P, Rosner GL, Akuthota P, Billheimer D, Bleecker ER, Cardet JC, Castro M, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Holguin F, Jain S, Kenyon NJ, Krishnan JA, Kraft M, Kumar R, Liu MC, Ly NP, Moy JN, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Wechsler ME, Wenzel SE, White SR. The precision interventions for severe and/or exacerbation-prone asthma (PrecISE) adaptive platform trial: statistical considerations. J Biopharm Stat. 2020 11 01; 30(6):1026-1037. PMID: 32941098; PMCID: PMC7954787.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  49. Li X, Christenson SA, Modena B, Li H, Busse WW, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Hastie AT, Israel E, Jarjour NN, Levy BD, Moore WC, Woodruff PG, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA. Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways. J Allergy Clin Immunol. 2021 03; 147(3):894-909. PMID: 32795586; PMCID: PMC7876167.
    Citations: 12     Fields:    Translation:HumansCells
  50. Peters MC, Sajuthi S, Deford P, Christenson S, Rios CL, Montgomery MT, Woodruff PG, Mauger DT, Erzurum SC, Johansson MW, Denlinger LC, Jarjour NN, Castro M, Hastie AT, Moore W, Ortega VE, Bleecker ER, Wenzel SE, Israel E, Levy BD, Seibold MA, Fahy JV. COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids. Am J Respir Crit Care Med. 2020 07 01; 202(1):83-90. PMID: 32348692; PMCID: PMC7328313.
    Citations: 174     Fields:    Translation:HumansCellsPHPublic Health
  51. Wardlaw A, Howarth PH, Israel E, Taillé C, Quirce S, Mallett S, Bates S, Albers FC, Kwon N. Fungal sensitization and its relationship to mepolizumab response in patients with severe eosinophilic asthma. Clin Exp Allergy. 2020 07; 50(7):869-872. PMID: 32515118.
    Citations: 5     Fields:    Translation:HumansAnimalsCTClinical Trials
  52. Israel E, Hogan MB. Personalizing Precision Medicine. J Allergy Clin Immunol Pract. 2020 05; 8(5):1614-1615. PMID: 32389277.
    Citations:    Fields:    Translation:HumansCells
  53. Durack J, Christian LS, Nariya S, Gonzalez J, Bhakta NR, Ansel KM, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Peters SP, Rosenberg SR, Sorkness CA, Wechsler ME, Wenzel SE, White SR, Lynch SV, Boushey HA, Huang YJ. Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma. J Allergy Clin Immunol. 2020 11; 146(5):1016-1026. PMID: 32298699; PMCID: PMC7554083.
    Citations: 10     Fields:    Translation:HumansCellsCTClinical Trials
  54. Howarth P, Quirce S, Papi A, Israel E, Mallett S, Bates S, Yancey S, Albers FC, Kwon N. Eosinophil-derived neurotoxin and clinical outcomes with mepolizumab in severe eosinophilic asthma. Allergy. 2020 08; 75(8):2085-2088. PMID: 32147844.
    Citations: 1     Fields:    Translation:HumansCells
  55. Hastie AT, Mauger DT, Denlinger LC, Coverstone A, Castro M, Erzurum S, Jarjour N, Levy BD, Meyers DA, Moore WC, Phillips B, Wenzel SE, Fahy JV, Israel E, Bleecker ER. Baseline sputum eosinophil + neutrophil subgroups' clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) cohort. J Allergy Clin Immunol. 2020 07; 146(1):222-226. PMID: 32032631; PMCID: PMC7343602.
    Citations: 9     Fields:    Translation:HumansCellsCTClinical Trials
  56. Wechsler ME, Ortega VE, Israel E. Step-Up Therapy in Black Patients with Asthma. Reply. N Engl J Med. 2020 01 23; 382(4):391-392. PMID: 31971690.
    Citations:    Fields:    Translation:Humans
  57. Zein J, Gaston B, Bazeley P, DeBoer MD, Igo RP, Bleecker ER, Meyers D, Comhair S, Marozkina NV, Cotton C, Patel M, Alyamani M, Xu W, Busse WW, Calhoun WJ, Ortega V, Hawkins GA, Castro M, Chung KF, Fahy JV, Fitzpatrick AM, Israel E, Jarjour NN, Levy B, Mauger DT, Moore WC, Noel P, Peters SP, Teague WG, Wenzel SE, Erzurum SC, Sharifi N. HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2187-2193. PMID: 31932420.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  58. Cardet JC, Busse PJ, Carroll JK, Casale TB, Coyne-Beasley T, Dixon-Williams S, Fagan M, Forth VE, Fuhlbrigge AL, Hernandez ML, Kaelber D, Kaplan B, Lorenzi M, Madison S, Maher NE, Majewski K, Manning B, McKee MD, Nazario S, Pace WD, Pencina MJ, Rand CS, Rodriguez-Louis J, She L, Shields J, Teng JE, Wechsler ME, Wisnivesky JP, Yawn BP, Israel E. Adherence to adding inhaled corticosteroids to rescue therapy in a pragmatic trial with adults with asthma: A pilot study. Ann Allergy Asthma Immunol. 2020 05; 124(5):487-493.e1. PMID: 31923550; PMCID: PMC7188592.
    Citations: 2     Fields:    Translation:Humans
  59. Owens RL, Campana LM, Foster AM, Schomer AM, Israel E, Malhotra A. Nocturnal bilevel positive airway pressure for the treatment of asthma. Respir Physiol Neurobiol. 2020 03; 274:103355. PMID: 31805396; PMCID: PMC8884694.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  60. Ross KR, Gupta R, DeBoer MD, Zein J, Phillips BR, Mauger DT, Li C, Myers RE, Phipatanakul W, Fitzpatrick AM, Ly NP, Bacharier LB, Jackson DJ, Celedón JC, Larkin A, Israel E, Levy B, Fahy JV, Castro M, Bleecker ER, Meyers D, Moore WC, Wenzel SE, Jarjour NN, Erzurum SC, Teague WG, Gaston B. Severe asthma during childhood and adolescence: A longitudinal study. J Allergy Clin Immunol. 2020 01; 145(1):140-146.e9. PMID: 31622688.
    Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
  61. Fitzpatrick AM, Szefler SJ, Mauger DT, Phillips BR, Denlinger LC, Moore WC, Sorkness RL, Wenzel SE, Gergen PJ, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Israel E, Levy BD, Meyers DA, Teague WG, Bacharier LB, Ly NP, Phipatanakul W, Ross KR, Zein J, Jarjour NN. Development and initial validation of the Asthma Severity Scoring System (ASSESS). J Allergy Clin Immunol. 2020 01; 145(1):127-139. PMID: 31604088; PMCID: PMC6949388.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  62. Wechsler ME, Szefler SJ, Ortega VE, Pongracic JA, Chinchilli V, Lima JJ, Krishnan JA, Kunselman SJ, Mauger D, Bleecker ER, Bacharier LB, Beigelman A, Benson M, Blake KV, Cabana MD, Cardet JC, Castro M, Chmiel JF, Covar R, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Grossman N, Holguin F, Jackson DJ, Kumar H, Kraft M, LaForce CF, Lang J, Lazarus SC, Lemanske RF, Long D, Lugogo N, Martinez F, Meyers DA, Moore WC, Moy J, Naureckas E, Olin JT, Peters SP, Phipatanakul W, Que L, Raissy H, Robison RG, Ross K, Sheehan W, Smith LJ, Solway J, Sorkness CA, Sullivan-Vedder L, Wenzel S, White S, Israel E. Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma. N Engl J Med. 2019 09 26; 381(13):1227-1239. PMID: 31553835; PMCID: PMC7026584.
    Citations: 13     Fields:    Translation:Humans